Novel compositions and methods in cancer

ABSTRACT

The present invention relates to novel sequences for use in detection, diagnosis and treatment of cancers. The invention provides cancer-associated (CA) polynucleotide sequences whose expression is associated with cancer. The present invention provides CA polypeptides associated with cancer and provides diagnostic compositions and methods for the detection of cancer. The present invention provides monoclonal and polyclonal antibodies specific for the CA polypeptides. The present invention also provides diagnostic tools and therapeutic compositions and methods for screening, prevention and treatment of cancer.

CROSS-REFERENCE TO RELATED APPLICATIONS

[0001] This application claims priority to U.S. provisional applicationSer. No. 60/367,025 entitled “Novel Compositions and Methods in Cancer,”filed Mar. 21, 2002. This application is related to U.S. Applicationsentitled “Novel Compositions and Methods in Cancer,” U.S. Ser. No.09/747,377, filed Dec. 22, 2000, U.S. Ser. No. 09/798,586, filed Mar. 2,2001, U.S. Ser. No. 10/004,113, filed Oct. 23, 2001, U.S. Ser. No.10/052,482, filed Nov. 8, 2001 and U.S. Ser. No. 09/997,722, filed Nov.30, 2001, all of which are expressly incorporated herein by reference intheir entirety.

TECHNICAL FIELD OF THE INVENTION

[0002] This invention relates generally to the field ofcancer-associated genes. Specifically, it relates to novel sequences foruse in diagnosis and treatment of cancer and tumors, as well as the useof the novel compositions in screening methods. The present inventionprovides methods of using cancer associated polynucleotides, theircorresponding gene products and antibodies specific for the geneproducts in the detection, diagnosis, prevention and/or treatment ofassociated cancers.

BACKGROUND OF THE INVENTION

[0003] Oncogenes are genes that can cause cancer. Carcinogenesis canoccur by a wide variety of mechanisms, including infection of cells byviruses containing oncogenes, activation of protooncogenes in the hostgenome, and mutations of protooncogenes and tumor suppressor genes.Carcinogenesis is fundamentally driven by somatic cell evolution (i.e.mutation and natural selection of variants with progressive loss ofgrowth control). The genes that serve as targets for these somaticmutations are classified as either protooncogenes or tumor suppressorgenes, depending on whether their mutant phenotypes are dominant orrecessive, respectively.

[0004] There are a number of viruses known to be involved in humancancer as well as in animal cancer. Of particular interest here areviruses that do not contain oncogenes themselves; these areslow-transforming retroviruses. They induce tumors by integrating intothe host genome and affecting neighboring protooncogenes in a variety ofways. Provirus insertion mutation is a normal consequence of theretroviral life cycle. In infected cells, a DNA copy of the retrovirusgenome (called a provirus) is integrated into the host genome. A newlyintegrated provirus can affect gene expression in cis at or near theintegration site by one of two mechanisms. Type I insertion mutationsup-regulate transcription of proximal genes as a consequence ofregulatory sequences (enhancers and/or promoters) within the provirallong terminal repeats (LTRs). Type II insertion mutations causetruncation of coding regions due to either integration directly withinan open reading frame or integration within an intron flanked on bothsides by coding sequences. The analysis of sequences at or near theinsertion sites has led to the identification of a number of newprotooncogenes.

[0005] With respect to lymphoma and leukemia, retroviruses such as AKVmurine leukemia virus (MLV) or SL3-3 MLV, are potent inducers of tumorswhen inoculated into susceptible newborn mice, or when carried in thegermline. A number of sequences have been identified as relevant in theinduction of lymphoma and leukemia by analyzing the insertion sites; seeSorensen et al., J. of Virology 74:2161 (2000); Hansen et al., GenomeRes. 10(2):237-43 (2000); Sorensen et al., J. Virology 70:4063 (1996);Sorensen et al., J. Virology 67:7118 (1993); Joosten et al., Virology268:308 (2000); and Li et al., Nature Genetics 23:348 (1999); all ofwhich are expressly incorporated by reference herein. With respect tocancers, especially breast cancer, prostate cancer and cancers withepithelial origin, the mammalian retrovirus, mouse mammary tumor virus(MMTV) is a potent inducer of tumors when inoculated into susceptiblenewborn mice, or when carried in the germ line. Mammary Tumors in theMouse, edited by J. Hilgers and M. Sluyser; Elsevier/North-HollandBiomedical Press; New York, N.Y.

[0006] Breast cancer is one of the most significant diseases thataffects women. At the current rate, American women have a 1 in 8 risk ofdeveloping breast cancer by age 95 (American Cancer Society, 1992).Treatment of breast cancer at later stages is often futile anddisfiguring, making early detection a high priority in medicalmanagement of the disease.

[0007] The pattern of gene expression in a particular living cell ischaracteristic of its current state. Nearly all differences in the stateor type of a cell are reflected in the differences in RNA levels of oneor more genes. Comparing expression patterns of uncharacterized genesmay provide clues to their function. High throughput analysis ofexpression of hundreds or thousands of genes can help in (a)identification of complex genetic diseases, (b) analysis of differentialgene expression over time, between tissues and disease states, and (c)drug discovery and toxicology studies. Increase or decrease in thelevels of expression of certain genes correlate with cancer biology. Forexample, oncogenes are positive regulators of tumorigenesis, while tumorsuppressor genes are negative regulators of tumorigenesis. (Marshall,Cell, 64: 313-326 (1991); Weinberg, Science, 254: 1138-1146 (1991)).

[0008] SNL, which also in known as fascin, is an actin-bundling proteinthat was first isolated from cytoplasmic extracts of sea urchin eggs(Kane, 1975: J. Cell Biol. 66:305-315) and was the first bundlingprotein to be characterized in vitro. Subsequent work has shown thatfascin bundles actin filaments in fertilized egg microvilli andfilopodia of phagocytic coelomocytes (Otto et al., 1980, Cell Motil.1:31-40; Otto and Bryan, 1981, Cell Motil. 1: 179-192). Fascin is awidely expressed protein found in a broad spectrum of tissues andorganisms.

[0009] In vivo, AP-1, or transcription factor activating protein 1, is aheterogenous mixture of heterodimers of several related protein subunitsin addition to c-Fos and c-Jun including FosB, Fra-1, Fra-2, c-Jun,JunB, JunD, etc. (The FOS and JUN Families of Proteins, Angel andHerrlich, eds., CRC Press, Boca Raton, Fla., 1994). While AP-1 has beenimplicated in abnormal cell proliferation and tumor formation, eventsthat thus might be controlled by modulating the expression of c-fosand/or c-jun, the precise contribution of each of these proteins to cellproliferation or tumor formation is unclear.

[0010] The c-myc protein is a member of the helix-loop-helix/leucinezipper (HLH/LZ) family of transcription factors that forms heterodimerswith Max. In general, trans-activating Myc:Max heterodimers are found inproliferating cells, while trans-repressing Mad:Max heterodimers arefound in differentiated cells. The c-myc protein level influences cellproliferation, differentiation, and neoplastic transformation,presumably by affecting the balance between Myc:Max and Mad:Maxheterodimers.

[0011] Cyclin D1 is a protein derived from the PRAD1, CCND1 or bcl-1gene on chromosome 11q13, which is involved in both regulation of thecell cycle. In the G1 (resting) phase of the cell cycle, cyclin D1together with its cyclin dependent kinase (cdk) partner, is responsiblefor transition to the S (DNA synthesis) phase by phosphorylating theproduct of the retinoblastoma gene (pRB), which then releasestranscription factors important in the initiation of DNA replication.The nuclear factor-κ B is an inducible transcription factor whichparticipates in the regulation of multiple cellular genes aftertreatment of cells with factors such as phorbol ester,lipopolysaccharide (LPS), interleukin-1 (IL-1) and tumor necrosisfactor-α (TNF-alpha). These genes are involved in the immediate earlyprocesses of immune, acute phase, and inflammatory responses. NF-κB hasalso been implicated in the transcriptional activation of severalviruses, most notably the type 1 human immunodeficiency virus (HIV-1)and cytomegalovirus (CMV) (Nabel, et al., Nature, 326:711, 1987;Kaufman, et al., Mol. Cell. Biol., 7:3759, 1987; Sambucetti, et al.,EMBO J, 8:4251, 1989). NF-κB is a dimeric transcription factor thatbinds and regulates gene expression through decameric cis-acting NF-κBDNA motifs. Although a p50/p65 heterodimer has traditionally beenreferred to as NF-κB and remains the prototypical and most abundantform, it has been recognized recently that several distinct but closelyrelated homo- and heterodimeric factors are responsible for NF-κBsite-dependent DNA binding activity and regulation. The various dimericfactors are composed of members of the family of Rel-relatedpolypeptides. One subclass of this family, distinguished by itsproteolytic processing from precursor forms and lack of recognizedactivation domains, includes p50 (NFKB1) and p50B (NFKB2, p52), whereasthe second subclass contains recognized activation domains and includesp65 (RelA), RelB, c-Rel, and the Drosophila protein Dorsal. AllRel-related members share a 300-amino acid region of homology, RHD,responsible for DNA binding and dimerization, called the Rel homologydomain. In the cytoplasm, NF-κB and Rel proteins form a “Rel complex”.

[0012] NF-κB gene regulation is involved in many pathological eventsincluding progression of acquired immune deficiency disease (AIDS), theacute phase response and the activation of immune and endothelial cellsduring toxic shock, allograft rejection, and radiation responses. Inaddition, NF-κB gene transactivation may be critical for HIV and CMVreplication.

[0013] The PVT-1 locus is associated with the c-myc locus. Frequently,mutations in one or the other loci correlate with disease such aslymphoma. While rearrangements and amplification of the PVT locus havebeen found in lymphomas, the role of PVT-1 remains unclear.

[0014] Accordingly, it is an object of the invention to providepolynucleotide and polypeptide sequences involved in cancer and, inparticular, in oncogenesis.

[0015] Immunotherapy, or the use of antibodies for therapeutic purposeshas been used in recent years to treat cancer. Passive immunotherapyinvolves the use of monoclonal antibodies in cancer treatments. See forexample, Cancer: Principles and Practice of Oncology, 6^(th) Edition(2001) Ch. 20, pp. 495-508. Inherent therapeutic biological activity ofthese antibodies include direct inhibition of tumor cell growth orsurvival, and the ability to recruit the natural cell killing activityof the body's immune system. These agents are administered alone or inconjunction with radiation or chemotherapeutic agents. Rituxan® andHerceptin®, approved for treatment of lymphoma and breast cancer,respectively, are two examples of such therapeutics. Alternatively,antibodies are used to make antibody conjugates where the antibody islinked to a toxic agent and directs that agent to the tumor byspecifically binding to the tumor. Mylotarg® is an example of anapproved antibody conjugate used for the treatment of leukemia.

[0016] Accordingly, it is another object of this invention to provideantigens (cancer-associated polypeptides) associated with a variety ofcancers as targets for diagnostic and/or therapeutic antibodies. Theseantigens are also useful for drug discovery (e.g., small molecules) andfor further characterization of cellular regulation, growth, anddifferentiation.

SUMMARY OF THE INVENTION

[0017] In accordance with the objects outlined above, the presentinvention provides methods for screening for compositions that modulatecancer, especially lymphoma and leukemia. The present invention alsoprovides methods for screening for compositions which modulatecarcinomas, especially mammary adenocarcinomas. Also provided herein aremethods of inhibiting proliferation of a cell, preferably a lymphomacell or a breast cancer cell. Methods of treatment of cancer, includingdiagnosis, are also provided herein.

[0018] In one aspect, a method of screening drug candidates comprisesproviding a cell that expresses a cancer-associated (CA) gene orfragments thereof. Preferred embodiments of CA genes are genes that aredifferentially expressed in cancer cells, preferably lymphatic, breast,prostate or epithelial cells, compared to other cells. Preferredembodiments of CA genes used in the methods herein include, but are notlimited to the nucleic acids selected from Tables 1-6. That is, theyinclude but are not limited to PVT1, SNL1, CCND1, FOSB, MYC, or NFKB1.The methods further include adding a drug candidate to the cell anddetermining the effect of the drug candidate on the expression of the CAgene.

[0019] In one embodiment, the method of screening drug candidatesincludes comparing the level of expression in the absence of the drugcandidate to the level of expression in the presence of the drugcandidate.

[0020] Also provided herein is a method of screening for a bioactiveagent capable of binding to a CA protein (CAP), the method comprisingcombining the CAP and a candidate bioactive agent, and determining thebinding of the candidate agent to the CAP.

[0021] Further provided herein is a method for screening for a bioactiveagent capable of modulating the activity of a CAP. In one embodiment,the method comprises combining the CAP and a candidate bioactive agent,and determining the effect of the candidate agent on the bioactivity ofthe CAP.

[0022] Also provided is a method of evaluating the effect of a candidatecarcinoma drug comprising administering the drug to a patient andremoving a cell sample from the patient. The expression profile of thecell is then determined. This method may further comprise comparing theexpression profile of the patient to an expression profile of a heathyindividual.

[0023] In a further aspect, a method for inhibiting the activity of anCA protein is provided. In one embodiment, the method comprisesadministering to a patient an inhibitor of a CA protein preferablyselected from the group consisting of the sequences outlined in Tables1-6 or their complements.

[0024] A method of neutralizing the effect of a CA protein, preferably aprotein encoded by a nucleic acid selected from the group of sequencesoutlined in Tables 1-6, is also provided. Preferably, the methodcomprises contacting an agent specific for said protein with saidprotein in an amount sufficient to effect neutralization.

[0025] Moreover, provided herein is a biochip/microarray comprising anucleic acid segment which encodes a CA protein, preferably selectedfrom the sequences outlined in Tables 1-6. That is, they include but arenot limited to genes including PVT1, SNL1, CCND1, FOSB, MYC, or NFKB1.In different embodiments, a microarray of the invention comprises one,two, three, four, five or more human sequences from Tables 1-6including, but not limited to, sequences related to PVT1, SNL1, CCND1,FOSB, MYC, or NFKB1.

[0026] Also provided herein is a method for diagnosing or determiningthe propensity to: cancers, especially lymphoma or leukemia or carcinoma(including breast cancer) by sequencing at least one carcinoma orlymphoma gene of an individual. In yet another aspect of the invention,a method is provided for determining cancer including lymphoma andleukemia gene copy numbers in an individual.

[0027] Novel sequences associated with cancer are also provided herein.Other aspects of the invention will become apparent to the skilledartisan by the following description of the invention.

BRIEF DESCRIPTION OF THE FIGURES

[0028]FIG. 1 depicts PCR amplification of host-provirus junctionfragments.

[0029]FIG. 2 shows an example of average threshold cycle (CT) values fora housekeeper gene and target gene.

[0030]FIG. 3 shows an example of the calculated difference (ΔΔC_(T))between the C_(T) values of target and housekeeper genes (ΔC_(T)) forvarious samples.

[0031]FIG. 4 shows the ΔΔC_(T) and comparative expression level for eachsample from FIG. 3.

[0032]FIG. 5 depicts mRNA expression of SNL1 in breast cancer tissuecompared with expression in normal tissue. Samples 1-50 are breastcancer samples. Samples 51 and 52 are normal tissues. Bars represent themean of expression level. Error bars represent standard deviation.

[0033]FIG. 5 depicts mRNA expression of FOSB in colon cancer tissuecompared with expression in normal tissue. Samples 1-11 are normalsamples. Samples 12-31 are colon cancer tissues. Bars represent the meanof expression level. Error bars represent standard deviation.

[0034]FIG. 7 depicts mRNA expression of FOSB in lung cancer tissuecompared with expression in normal tissue. Samples 1-9 are normalsamples. Samples 10-43 are lung cancer tissues. Bars represent the meanof expression level. Error bars represent standard deviation.

[0035]FIG. 8 depicts mRNA expression of FOSB in pancreas cancer tissuecompared with expression in normal tissue. Samples 1-10 are normalsamples. Samples 11-31 are pancreas cancer tissues. Bars represent themean of expression level. Error bars represent standard deviation.

[0036]FIG. 9 depicts mRNA expression of FOSB in ovary cancer tissuecompared with expression in normal tissue. Samples 1-16 are normalsamples. Samples 17-44 are ovary cancer tissues. Bars represent the meanof expression level. Error bars represent standard deviation.

[0037]FIG. 10 depicts mRNA expression of FOSB in stomach cancer tissuecompared with expression in normal tissue. Samples 1-10 are normalsamples. Samples 11-39 are stomach cancer tissues. Bars represent themean of expression level. Error bars represent standard deviation.

[0038]FIG. 11 depicts mRNA expression of FOSB in breast cancer tissuecompared with expression in normal tissue. Samples 1-9 are normalsamples. Samples 10-30 are breast cancer tissues. Bars represent themean of expression level. Error bars represent standard deviation.

[0039]FIG. 12 depicts mRNA expression of FOSB in prostate cancer tissuecompared with expression in normal tissue. Samples 1-7 are normalsamples. Samples 8-37 are prostate cancer tissues. Bars represent themean of expression level. Error bars represent standard deviation.

[0040]FIG. 13 depicts mRNA expression of MYC in breast cancer tissuecompared with expression in normal tissue. Samples 1-50 are breastcancer samples. Bars represent the mean of expression level. Error barsrepresent standard deviation.

[0041]FIG. 14 depicts DNA amplification of MYC in breast cancer tissuecompared with expression in normal tissue. Samples 1-49 are breastcancer samples. Bars represent the mean of expression level. Error barsrepresent standard deviation.

[0042]FIG. 15 depicts mRNA expression of CCND1 in breast cancer tissuecompared with expression in normal tissue. Samples 1-50 are breastcancer samples. Samples 51 and 52 are normal tissues. Bars represent themean of expression level. Error bars represent standard deviation.

[0043]FIG. 16 depicts mRNA expression of CCND1 in colon cancer (sigmoid)tissue compared with expression in normal tissue. Samples 1-12 arenormal samples. Samples 13-29 are colon cancer tissues. Bars representthe mean of expression level. Error bars represent standard deviation.

[0044]FIG. 17 depicts mRNA expression of CCND1 in colon cancer(transverse) tissue compared with expression in normal tissue. Samples1-12 are normal samples. Samples 13-30 are colon cancer tissues. Barsrepresent the mean of expression level. Error bars represent standarddeviation.

[0045]FIG. 18 depicts mRNA expression of CCND1 in lung tissue comparedwith expression in normal tissue. Samples 1-9 are normal samples.Samples 10-43 are lung cancer tissues. Bars represent the mean ofexpression level. Error bars represent standard deviation.

[0046]FIG. 19 depicts mRNA expression of CCND1 in ovary tissue comparedwith expression in normal tissue. Samples 1-14 are normal samples.Samples 15-41 are ovary cancer tissues. Bars represent the mean ofexpression level. Error bars represent standard deviation.

[0047]FIG. 20 depicts mRNA expression of NFKB1 in breast cancer tissuecompared with expression in normal tissue. Samples 1-50 are breastcancer samples. Samples 51 and 52 are normal tissues. Bars represent themean of expression level. Error bars represent standard deviation.

[0048]FIG. 21 depicts mRNA expression of NFKB1 in lung tissue comparedwith expression in normal tissue. Samples 1-9 are normal samples.Samples 10-44 are lung cancer tissues. Bars represent the mean ofexpression level. Error bars represent standard deviation.

[0049]FIG. 22 depicts mRNA expression of NFKB1 in skin tissue comparedwith expression in normal tissue. Samples 1-9 are normal samples.Samples 10-46 are skin cancer tissues. Bars represent the mean ofexpression level. Error bars represent standard deviation.

[0050]FIG. 23 depicts mRNA expression of PVT1 in breast cancer tissuecompared with expression in normal tissue. Samples 1-50 are breastcancer samples. Bars represent the mean of expression level. Error barsrepresent standard deviation.

[0051]FIG. 24 depicts DNA amplification of PVT1 in breast cancer tissuecompared with expression in normal tissue. Samples 1-50 are breastcancer samples. Bars represent the mean of expression level. Error barsrepresent standard deviation.

DETAILED DESCRIPTION OF PREFERRED EMBODIMENTS

[0052] The present invention is directed to a number of sequencesassociated with cancers, especially lymphoma, breast cancer or prostatecancer. The relatively tight linkage between clonally-integratedproviruses and protooncogenes forms “provirus tagging”, in whichslow-transforming retroviruses that act by an insertion mutationmechanism are used to isolate protooncogenes. In some models, uninfectedanimals have low cancer rates, and infected animals have high cancerrates. It is known that many of the retroviruses involved do not carrytransduced host protooncogenes or pathogenic trans-acting viral genes,and thus the cancer incidence must therefore be a direct consequence ofproviral integration effects into host protooncogenes. Since proviralintegration is random, rare integrants will “activate” hostprotooncogenes that provide a selective growth advantage, and these rareevents result in new proviruses at clonal stoichiometries in tumors. Incontrast to mutations caused by chemicals, radiation, or spontaneouserrors, protooncogene insertion mutations can be easily located byvirtue of the fact that a convenient-sized genetic marker of knownsequence (the provirus) is present at the site of mutation. Hostsequences that flank clonally integrated proviruses can be cloned usinga variety of strategies. Once these sequences are in hand, the taggedprotooncogenes can be subsequently identified. The presence of provirusat the same locus in two or more independent tumors is prima facieevidence that a protooncogene is present at or very near the provirusintegration sites. This is because the genome is too large for randomintegrations to result in observable clustering. Any clustering that isdetected is unequivocal evidence for biological selection (i.e. thetumor phenotype). Moreover, the pattern of proviral integrants(including orientations) provides compelling positional information thatmakes localization of the target gene at each cluster relatively simple.The three mammalian retroviruses that are known to cause cancer by aninsertion mutation mechanism are FeLV (leukemia/lymphoma in cats), MLV(leukemia/lymphoma in mice and rats), and MMTV (mammary cancer in mice).

[0053] Thus, the use of oncogenic retroviruses, whose sequences insertinto the genome of the host organism resulting in cancer, allows theidentification of host sequences involved in cancer. These sequences maythen be used in a number of different ways, including diagnosis,prognosis, screening for modulators (including both agonists andantagonists), antibody generation (for immunotherapy and imaging), etc.However, as will be appreciated by those in the art, oncogenes that areidentified in one type of cancer such as lymphoma or leukemia have astrong likelihood of being involved in other types of cancers as well.Thus, while the sequences outlined herein are initially identified ascorrelated with lymphoma, they can also be found in other types ofcancers as well, outlined below.

[0054] Definitions

[0055] Accordingly, the present invention provides nucleic acid andprotein sequences that are associated with cancer, herein termed “cancerassociated” or “CA” sequences. In one embodiment, the present inventionprovides nucleic acid and protein sequences that are associated withcancers that originate in lymphatic tissue, herein termed “lymphomaassociated,” “leukemia associated” or “LA” sequences. In anotherembodiment, the present invention provides nucleic acid and proteinsequences that are associated with carcinomas which originate in breasttissue, herein termed “breast cancer associated” or “BCA” sequences.

[0056] Suitable cancers that can be diagnosed or screened for using themethods of the present invention include cancers classified by site orby histological type. Cancers classified by site include cancer of theoral cavity and pharynx (lip, tongue, salivary gland, floor of mouth,gum and other mouth, nasopharynx, tonsil, oropharynx, hypopharynx, otheroral/pharynx); cancers of the digestive system (esophagus; stomach;small intestine; colon and rectum; anus, anal canal, and anorectum;liver; intrahepatic bile duct; gallbladder; other biliary; pancreas;retroperitoneum; peritoneum, omentum, and, mesentery; other digestive);cancers of the respiratory system (nasal cavity, middle ear, andsinuses; larynx; lung and bronchus; pleura; trachea, mediastinum, andother respiratory); cancers of the mesothelioma; bones and joints; andsoft tissue, including heart; skin cancers, including melanomas andother non-epithelial skin cancers; Kaposi's sarcoma and breast cancer;cancer of the female genital system (cervix uteri; corpus uteri; uterus,nos; ovary; vagina; vulva; and other female genital); cancers of themale genital system (prostate gland; testis; penis; and other malegenital); cancers of the urinary system (urinary bladder; kidney andrenal pelvis; ureter; and other urinary); cancers of the eye and orbit;cancers of the brain and nervous system (brain; and other nervoussystem); cancers of the endocrine system (thyroid gland and otherendocrine, including thymus); lymphomas (Hodgkin's disease andnon-Hodgkin's lymphoma), multiple myeloma, and leukemias (lymphocyticleukemia; myeloid leukemia; monocytic leukemia; and other leukemias).

[0057] Other cancers, classified by histological type, that may beassociated with the sequences of the invention include, but are notlimited to, Neoplasm, malignant; Carcinoma, NOS; Carcinoma,undifferentiated, NOS; Giant and spindle cell carcinoma; Small cellcarcinoma, NOS; Papillary carcinoma, NOS; Squamous cell carcinoma, NOS;Lymphoepithelial carcinoma; Basal cell carcinoma, NOS; Pilomatrixcarcinoma; Transitional cell carcinoma, NOS; Papillary transitional cellcarcinoma; Adenocarcinoma, NOS; Gastrinoma, malignant;Cholangiocarcinoma; Hepatocellular carcinoma, NOS; Combinedhepatocellular carcinoma and cholangiocarcinoma; Trabecularadenocarcinoma; Adenoid cystic carcinoma; Adenocarcinoma in adenomatouspolyp; Adenocarcinoma, familial polyposis coli; Solid carcinoma, NOS;Carcinoid tumor, malignant; Bronchiolo-alveolar adenocarcinoma;Papillary adenocarcinoma, NOS; Chromophobe carcinoma; Acidophilcarcinoma; Oxyphilic adenocarcinoma; Basophil carcinoma; Clear celladenocarcinoma, NOS; Granular cell carcinoma; Follicular adenocarcinoma,NOS; Papillary and follicular adenocarcinoma; Nonencapsulatingsclerosing carcinoma; Adrenal cortical carcinoma; Endometroid carcinoma;Skin appendage carcinoma; Apocrine adenocarcinoma; Sebaceousadenocarcinoma; Ceruminous adenocarcinoma; Mucoepidermoid carcinoma;Cystadenocarcinoma, NOS; Papillary cystadenocarcinoma, NOS; Papillaryserous cystadenocarcinoma; Mucinous cystadenocarcinoma, NOS; Mucinousadenocarcinoma; Signet ring cell carcinoma; Infiltrating duct carcinoma;Medullary carcinoma, NOS; Lobular carcinoma; Inflammatory carcinoma;Paget's disease, mammary; Acinar cell carcinoma; Adenosquamouscarcinoma; Adenocarcinoma w/ squamous metaplasia; Thymoma, malignant;Ovarian stromal tumor, malignant; Thecoma, malignant; Granulosa celltumor, malignant; Androblastoma, malignant; Sertoli cell carcinoma;Leydig cell tumor, malignant; Lipid cell tumor, malignant;Paraganglioma, malignant; Extra-mammary paraganglioma, malignant;Pheochromocytoma; Glomangiosarcoma; Malignant melanoma, NOS; Amelanoticmelanoma; Superficial spreading melanoma; Malig melanoma in giantpigmented nevus; Epithelioid cell melanoma; Blue nevus, malignant;Sarcoma, NOS; Fibrosarcoma, NOS; Fibrous histiocytoma, malignant;Myxosarcoma; Liposarcoma, NOS; Leiomyosarcoma, NOS; Rhabdomyosarcoma,NOS; Embryonal rhabdomyosarcoma; Alveolar rhabdomyosarcoma; Stromalsarcoma, NOS; Mixed tumor, malignant, NOS; Mullerian mixed tumor;Nephroblastoma; Hepatoblastoma; Carcinosarcoma, NOS; Mesenchymoma,malignant; Brenner tumor, malignant; Phyllodes tumor, malignant;Synovial sarcoma, NOS; Mesothelioma, malignant; Dysgerminoma; Embryonalcarcinoma, NOS; Teratoma, malignant, NOS; Struma ovarii, malignant;Choriocarcinoma; Mesonephroma, malignant; Hemangiosarcoma;Hemangioendothelioma, malignant; Kaposi's sarcoma; Hemangiopericytoma,malignant; Lymphangiosarcoma; Osteosarcoma, NOS; Juxtacorticalosteosarcoma; Chondrosarcoma, NOS; Chondroblastoma, malignant;Mesenchymal chondrosarcoma; Giant cell tumor of bone; Ewing's sarcoma;Odontogenic tumor, malignant; Ameloblastic odontosarcoma; Ameloblastoma,malignant; Ameloblastic fibrosarcoma; Pinealoma, malignant; Chordoma;Glioma, malignant; Ependymoma, NOS; Astrocytoma, NOS; Protoplasmicastrocytoma; Fibrillary astrocytoma; Astroblastoma; Glioblastoma, NOS;Oligodendroglioma, NOS; Oligodendroblastoma; Primitive neuroectodermal;Cerebellar sarcoma, NOS; Ganglioneuroblastoma; Neuroblastoma, NOS;Retinoblastoma, NOS; Olfactory neurogenic tumor; Meningioma, malignant;Neurofibrosarcoma; Neurilemmoma, malignant; Granular cell tumor,malignant; Malignant lymphoma, NOS; Hodgkin's disease, NOS; Hodgkin's;paragranuloma, NOS; Malignant lymphoma, small lymphocytic; Malignantlymphoma, large cell, diffuse; Malignant lymphoma, follicular, NOS;Mycosis fungoides; Other specified non-Hodgkin's lymphomas; Malignanthistiocytosis; Multiple myeloma; Mast cell sarcoma; Immunoproliferativesmall intestinal disease; Leukemia, NOS; Lymphoid leukemia, NOS; Plasmacell leukemia; Erythroleukemia; Lymphosarcoma cell leukemia; Myeloidleukemia, NOS; Basophilic leukemia; Eosinophilic leukemia; Monocyticleukemia, NOS; Mast cell leukemia; Megakaryoblastic leukemia; Myeloidsarcoma; and Hairy cell leukemia.

[0058] In addition, the CA genes may be involved in other diseases suchas, but not limited to, diseases associated with aging orneurodegeneration.

[0059] “Association” in this context means that the nucleotide orprotein sequences are either differentially expressed, activated,inactivated or altered in cancers as compared to normal tissue. Asoutlined below, CA sequences include those that are up-regulated (i.e.expressed at a higher level), as well as those that are down-regulated(i.e. expressed at a lower level), in cancers. CA sequences also includesequences that have been altered (i.e., truncated sequences or sequenceswith substitutions, deletions or insertions, including point mutations)and show either the same expression profile or an altered profile. In apreferred embodiment, the CA sequences are from humans; however, as willbe appreciated by those in the art, CA sequences from other organismsmay be useful in animal models of disease and drug evaluation; thus,other CA sequences are provided, from vertebrates, including mammals,including rodents (rats, mice, hamsters, guinea pigs, etc.), primates,and farm animals (including sheep, goats, pigs, cows, horses, etc). Insome cases, prokaryotic CA sequences may be useful. CA sequences fromother organisms may be obtained using the techniques outlined below.

[0060] CA sequences include both nucleic acid and amino acid sequences.In one embodiment, the CA sequences are recombinant nucleic acids. Bythe term “recombinant nucleic acid” herein is meant nucleic acid,originally formed in vitro, in general, by the manipulation of nucleicacid by polymerases and endonucleases, in a form not normally found innature. Thus a recombinant nucleic acid is also an isolated nucleicacid, in a linear form, or cloned in a vector formed in vitro byligating DNA molecules that are not normally joined, are both consideredrecombinant for the purposes of this invention. It is understood thatonce a recombinant nucleic acid is made and reintroduced into a hostcell or organism, it will replicate using the in vivo cellular machineryof the host cell rather than in vitro manipulations; however, suchnucleic acids, once produced recombinantly, although subsequentlyreplicated in vivo, are still considered recombinant or isolated for thepurposes of the invention. As used herein a “polynucleotide” or “nucleicacid” is a polymeric form of nucleotides of any length, eitherribonucleotides or deoxyribonucleotides. This term refers only to theprimary structure of the molecule. Thus, this term includes double- andsingle-stranded DNA and RNA. It also includes known types ofmodifications, for example, labels which are known in the art,methylation, “caps”, substitution of one or more of the naturallyoccurring nucleotides with an analog, internucleotide modifications suchas, for example, those with uncharged linkages (e.g., phosphorothioates,phosphorodithioates, etc.), those containing pendant moieties, such as,for example proteins (including e.g., nucleases, toxins, antibodies,signal peptides, poly-L-lysine, etc.), those with intercalators (e.g.,acridine, psoralen, etc.), those containing chelators (e.g., metals,radioactive metals, etc.), those containing alkylators, those withmodified linkages (e.g., alpha anomeric nucleic acids, etc.), as well asunmodified forms of the polynucleotide.

[0061] As used herein, a polynucleotide “derived from” a designatedsequence refers to a polynucleotide sequence which is comprised of asequence of approximately at least about 6 nucleotides, preferably atleast about 8 nucleotides, more preferably at least about 10-12nucleotides, and even more preferably at least about, 15-20 nucleotidescorresponding to a region of the designated nucleotide sequence.“Corresponding” means homologous to or complementary to the designatedsequence. Preferably, the sequence of the region from which thepolynucleotide is derived is homologous to or complementary to asequence that is unique to a CA gene.

[0062] Similarly, a “recombinant protein” is a protein made usingrecombinant techniques, i.e. through the expression of a recombinantnucleic acid as depicted above. A recombinant protein is distinguishedfrom naturally occurring protein by at least one or morecharacteristics. For example, the protein may be isolated or purifiedaway from some or all of the proteins and compounds with which it isnormally associated in its wild type host, and thus may be substantiallypure. For example, an isolated protein is unaccompanied by at least someof the material with which it is normally associated in its naturalstate, preferably constituting at least about 0.5%, more preferably atleast about 5% by weight of the total protein in a given sample. Asubstantially pure protein comprises about 50-75% by weight of the totalprotein, with about 80% being preferred, and about 90% beingparticularly preferred. The definition includes the production of a CAprotein from one organism in a different organism or host cell.Alternatively, the protein may be made at a significantly higherconcentration than is normally seen, through the use of an induciblepromoter or high expression promoter, such that the protein is made atincreased concentration levels. Alternatively, the protein may be in aform not normally found in nature, as in the addition of an epitope tagor amino acid substitutions, insertions and deletions, as discussedbelow.

[0063] In a preferred embodiment, the CA sequences are nucleic acids. Aswill be appreciated by those in the art and is more fully outlinedbelow, CA sequences are useful in a variety of applications, includingdiagnostic applications, which will detect naturally occurring nucleicacids, as well as screening applications; for example, biochipscomprising nucleic acid probes to the CA sequences can be generated. Inthe broadest sense, use of “nucleic acid,” “polynucleotide” or“oligonucleotide” or equivalents herein means at least two nucleotidescovalently linked together. In some embodiments, an oligonucleotide isan oligomer of 6, 8, 10, 12, 20, 30 or up to 100 nucleotides. A“polynucleotide” or “oligonucleotide” may comprise DNA, RNA, PNA or apolymer of nucleotides linked by phosphodiester and/or any alternatebonds.

[0064] A nucleic acid of the present invention generally containsphosphodiester bonds, although in some cases, as outlined below (forexample, in antisense applications or when a nucleic acid is a candidatedrug agent), nucleic acid analogs may have alternate backbones,comprising, for example, phosphoramidate (Beaucage et al., Tetrahedron49(10):1925 (1993) and references therein; Letsinger, J. Org. Chem.35:3800 (1970); Sprinzl et al., Eur. J. Biochem. 81:579 (1977);Letsinger et al., Nucl. Acids Res. 14:3487 (1986); Sawai et al, Chem.Lett. 805 (1984), Letsinger et al., J. Am. Chem. Soc. 110:4470 (1988);and Pauwels et al., Chemica Scripta 26:141 91986)), phosphorothioate(Mag et al., Nucleic Acids Res. 19:1437 (1991); and U.S. Pat. No.5,644,048), phosphorodithioate (Briu et al., J. Am. Chem. Soc. 111:2321(1989), O-methylphosphoroamidite linkages (see Eckstein,Oligonucleotides and Analogues: A Practical Approach, Oxford UniversityPress), and peptide nucleic acid backbones and linkages (see Egholm, J.Am. Chem. Soc. 114:1895 (1992); Meier et al., Chem. Int. Ed. Engl.31:1008 (1992); Nielsen, Nature, 365:566 (1993); Carlsson et al., Nature380:207 (1996), all of which are incorporated by reference). Otheranalog nucleic acids include those with positive backbones (Denpcy etal., Proc. Natl. Acad. Sci. USA 92:6097 (1995); non-ionic backbones(U.S. Pat. Nos. 5,386,023, 5,637,684, 5,602,240, 5,216,141 and4,469,863; Kiedrowshi et al., Angew. Chem. Intl. Ed. English 30:423(1991); Letsinger et al., J. Am. Chem. Soc. 110:4470 (1988); Letsingeret al., Nucleoside & Nucleotide 13:1597 (1994); Chapters 2 and 3, ASCSymposium Series 580, “Carbohydrate Modifications in AntisenseResearch”, Ed. Y. S. Sanghui and P. Dan Cook; Mesmaeker et al.,Bioorganic & Medicinal Chem. Lett. 4:395 (1994); Jeffs et al., J.Biomolecular NMR 34:17 (1994); Tetrahedron Lett. 37:743 (1996)) andnon-ribose backbones, including those described in U.S. Pat. Nos.5,235,033 and 5,034,506, and Chapters 6 and 7, ASC Symposium Series 580,“Carbohydrate Modifications in Antisense Research”, Ed. Y. S. Sanghuiand P. Dan Cook. Nucleic acids containing one or more carbocyclic sugarsare also included within one definition of nucleic acids (see Jenkins etal., Chem. Soc. Rev. (1995) pp169-176). Several nucleic acid analogs aredescribed in Rawls, C & E News Jun. 2, 1997 page 35. All of thesereferences are hereby expressly incorporated by reference. Thesemodifications of the ribose-phosphate backbone may be done for a varietyof reasons, for example to increase the stability and half-life of suchmolecules in physiological environments for use in anti-senseapplications or as probes on a biochip.

[0065] As will be appreciated by those in the art, all of these nucleicacid analogs may find use in the present invention. In addition,mixtures of naturally occurring nucleic acids and analogs can be made;alternatively, mixtures of different nucleic acid analogs, and mixturesof naturally occurring nucleic acids and analogs may be made.

[0066] The nucleic acids may be single stranded or double stranded, asspecified, or contain portions of both double stranded or singlestranded sequence. As will be appreciated by those in the art, thedepiction of a single strand “Watson” also defines the sequence of theother strand “Crick”; thus the sequences described herein also includesthe complement of the sequence. The nucleic acid may be DNA, bothgenomic and cDNA, RNA, or a hybrid, where the nucleic acid contains anycombination of deoxyribo- and ribo-nucleotides, and any combination ofbases, including uracil, adenine, thymine, cytosine, guanine, inosine,xanthine, hypoxanthine, isocytosine, isoguanine, etc. As used herein,the term “nucleoside” includes nucleotides and nucleoside and nucleotideanalogs, and modified nucleosides such as amino modified nucleosides. Inaddition, “nucleoside” includes non-naturally occurring analogstructures. Thus for example the individual units of a peptide nucleicacid, each containing a base, are referred to herein as a nucleoside.

[0067] As used herein, the term “tag,” “sequence tag” or “primer tagsequence” refers to an oligonucleotide with specific nucleic acidsequence that serves to identify a batch of polynucleotides bearing suchtags therein. Polynucleotides from the same biological source arecovalently tagged with a specific sequence tag so that in subsequentanalysis the polynucleotide can be identified according to its source oforigin. The sequence tags also serve as primers for nucleic acidamplification reactions.

[0068] A “microarray” is a linear or two-dimensional array of preferablydiscrete regions, each having a defined area, formed on the surface of asolid support. The density of the discrete regions on a microarray isdetermined by the total numbers of target polynucleotides to be detectedon the surface of a single solid phase support, preferably at leastabout 50/cm², more preferably at least about 100/cm², even morepreferably at least about 500/cm², and still more preferably at leastabout 1,000/cm². As used herein, a DNA microarray is an array ofoligonucleotide primers placed on a chip or other surfaces used toamplify or clone target polynucleotides. Since the position of eachparticular group of primers in the array is known, the identities of thetarget polynucleotides can be determined based on their binding to aparticular position in the microarray.

[0069] A “linker” is a synthetic oligodeoxyribonucleotide that containsa restriction site. A linker may be blunt end-ligated onto the ends ofDNA fragments to create restriction sites that can be used in thesubsequent cloning of the fragment into a vector molecule.

[0070] The term “label” refers to a composition capable of producing adetectable signal indicative of the presence of the targetpolynucleotide in an assay sample. Suitable labels includeradioisotopes, nucleotide chromophores, enzymes, substrates, fluorescentmolecules, chemiluminescent moieties, magnetic particles, bioluminescentmoieties, and the like. As such, a label is any composition detectableby spectroscopic, photochemical, biochemical, immunochemical,electrical, optical, chemical, or any other appropriate means. The term“label” is used to refer to any chemical group or moiety having adetectable physical property or any compound capable of causing achemical group or moiety to exhibit a detectable physical property, suchas an enzyme that catalyzes conversion of a substrate into a detectableproduct. The term “label” also encompasses compounds that inhibit theexpression of a particular physical property. The label may also be acompound that is a member of a binding pair, the other member of whichbears a detectable physical property.

[0071] The term “support” refers to conventional supports such as beads,particles, dipsticks, fibers, filters, membranes, and silane or silicatesupports such as glass slides.

[0072] The term “amplify” is used in the broad sense to mean creating anamplification product which may include, for example, additional targetmolecules, or target-like molecules or molecules complementary to thetarget molecule, which molecules are created by virtue of the presenceof the target molecule in the sample. In the situation where the targetis a nucleic acid, an amplification product can be made enzymaticallywith DNA or RNA polymerases or reverse transcriptases.

[0073] As used herein, a “biological sample” refers to a sample oftissue or fluid isolated from an individual, including but not limitedto, for example, blood, plasma, serum, spinal fluid, lymph fluid, skin,respiratory, intestinal and genitourinary tracts, tears, saliva, milk,cells (including but not limited to blood cells), tumors, organs, andalso samples of in vitro cell culture constituents.

[0074] The term “biological sources” as used herein refers to thesources from which the target polynucleotides are derived. The sourcecan be of any form of “sample” as described above, including but notlimited to, cell, tissue or fluid. “Different biological sources” canrefer to different cells/tissues/organs of the same individual, orcells/tissues/organs from different individuals of the same species, orcells/tissues/organs from different species.

[0075] Cancer-Associated Sequences

[0076] The CA sequences of the invention were initially identified byinfection of mice with a retrovirus such as murine leukemia virus (MLV)or mouse mammary tumor virus (MMTV) resulting in lymphoma. The CAsequences wre subsequently validated by determining expression levels ofthe corresponding gene product (e.g., mRNA) in breast cancer and othercancer tissue samples. Retroviruses have a genome that is made out ofRNA. After a retrovirus infects a host cell, a double stranded DNA copyof the retrovirus genome (a “provirus”) is inserted into the genomic DNAof the host cell. The integrated provirus may affect the expression ofhost genes at or near the site of integration—a phenomenon known asretroviral insertional mutagenesis. Possible changes in the expressionof host cell genes include: (i) increased expression of genes near thesite of integration resulting from the proximity of elements in theprovirus that act as transcriptional promoters and enhancers, (ii)functional inactivation of a gene caused by the integration of aprovirus into the gene itself thus preventing the synthesis of afunctional gene product, or (iii) expression of a mutated protein thathas a different activity to the normal protein. Typically such a proteinwould be prematurely truncated and lack a regulatory domain near the Cterminus. Such a protein might be constitutively active, or act as adominant negative inhibitor of the normal protein. For example,retrovirus enhancers, including that of SL3-3, are known to act on genesup to approximately 200 kilobases from the insertion site. Moreover,many of these sequences are also involved in other cancers and diseasestates. Sequences of mouse genes according to this invention, that areidentified in this manner are shown in Tables 1-6.

[0077] A CA sequence can be initially identified by substantial nucleicacid and/or amino acid sequence homology to the CA sequences outlinedherein. Such homology can be based upon the overall nucleic acid oramino acid sequence, and is generally determined as outlined below,using either homology programs or hybridization conditions.

[0078] In one embodiment, CA sequences are up-regulated in cancers; thatis, the expression of these genes is higher in cancer tissue as comparedto normal tissue of the same differentiation stage. “Up-regulation” asused herein means increased expression by about 50%, preferably about100%, more preferably about 150% to about 200%, with up-regulation from300% to 1000% being preferred.

[0079] In another embodiment, CA sequences are down-regulated incancers; that is, the expression of these genes is lower in cancertissue as compared to normal tissue of the same differentiation stage.“Down-regulation” as used herein means decreased expression by about50%, preferably about 100%, more preferably about 150% to about 200%,with down-regulation from 300% to 1000% to no expression beingpreferred.

[0080] In yet another embodiment, CA sequences are those that havealtered sequences but show either the same or an altered expressionprofile as compared to normal lymphoid tissue of the samedifferentiation stage. “Altered CA sequences” as used herein also refersto sequences that are truncated, contain insertions or contain pointmutations.

[0081] CA proteins of the present invention may be classified assecreted proteins, transmembrane proteins or intracellular proteins. Ina preferred embodiment the CA protein is an intracellular protein.Intracellular proteins may be found in the cytoplasm and/or in thenucleus. Intracellular proteins are involved in all aspects of cellularfunction and replication (including, for example, signaling pathways);aberrant expression of such proteins results in unregulated ordisregulated cellular processes. For example, many intracellularproteins have enzymatic activity such as protein kinase activity,protein phosphatase activity, protease activity, nucleotide cyclaseactivity, polymerase activity and the like. Intracellular proteins alsoserve as docking proteins that are involved in organizing complexes ofproteins, or targeting proteins to various subcellular localizations,and are involved in maintaining the structural integrity of organelles.

[0082] An increasingly appreciated concept in characterizingintracellular proteins is the presence in the proteins of one or moremotifs for which defined functions have been attributed. In addition tothe highly conserved sequences found in the enzymatic domain ofproteins, highly conserved sequences have been identified in proteinsthat are involved in protein-protein interaction. For example,Src-homology-2 (SH2) domains bind tyrosine-phosphorylated targets in asequence dependent manner. PTB domains, which are distinct from SH2domains, also bind tyrosine phosphorylated targets. SH3 domains bind toproline-rich targets. In addition, PH domains, tetratricopeptide repeatsand WD domains to name only a few, have been shown to mediateprotein-protein interactions. Some of these may also be involved inbinding to phospholipids or other second messengers. As will beappreciated by one of ordinary skill in the art, these motifs can beidentified on the basis of primary sequence; thus, an analysis of thesequence of proteins may provide insight into both the enzymaticpotential of the molecule and/or molecules with which the protein mayassociate.

[0083] In a preferred embodiment, the CA sequences are transmembraneproteins. Transmembrane proteins are molecules that span thephospholipid bilayer of a cell. They may have an intracellular domain,an extracellular domain, or both. The intracellular domains of suchproteins may have a number of functions including those alreadydescribed for intracellular proteins. For example, the intracellulardomain may have enzymatic activity and/or may serve as a binding sitefor additional proteins. Frequently the intracellular domain oftransmembrane proteins serves both roles. For example certain receptortyrosine kinases have both protein kinase activity and SH2 domains. Inaddition, autophosphorylation of tyrosines on the receptor moleculeitself creates binding sites for additional SH2 domain containingproteins.

[0084] Transmembrane proteins may contain from one to many transmembranedomains. For example, receptor tyrosine kinases, certain cytokinereceptors, receptor guanylyl cyclases and receptor serine/threonineprotein kinases contain a single transmembrane domain. However, variousother proteins including channels and adenylyl cyclases contain numeroustransmembrane domains. Many important cell surface receptors areclassified as “seven transmembrane domain” proteins, as they contain 7membrane spanning regions. Important transmembrane protein receptorsinclude, but are not limited to insulin receptor, insulin-like growthfactor receptor, human growth hormone receptor, glucose transporters,transferrin receptor, epidermal growth factor receptor, low densitylipoprotein receptor, leptin receptor, interleukin receptors, e.g. IL-1receptor, IL-2 receptor, etc. CA proteins may be derived from genes thatregulate apoptosis (IL-3, GM-CSF and Bcl-x) or are shown to have a rolein the regulation of apoptosis.

[0085] Characteristics of transmembrane domains include approximately 20consecutive hydrophobic amino acids that may be followed by chargedamino acids. Therefore, upon analysis of the amino acid sequence of aparticular protein, the localization and number of transmembrane domainswithin the protein may be predicted.

[0086] The extracellular domains of transmembrane proteins are diverse;however, conserved motifs are found repeatedly among variousextracellular domains. Conserved structure and/or functions have beenascribed to different extracellular motifs. For example, cytokinereceptors are characterized by a cluster of cysteines and a WSXWS(W=tryptophan, S=serine, X=any amino acid) motif. Immunoglobulin-likedomains are highly conserved. Mucin-like domains may be involved in celladhesion and leucine-rich repeats participate in protein-proteininteractions.

[0087] Many extracellular domains are involved in binding to othermolecules. In one aspect, extracellular domains are receptors. Factorsthat bind the receptor domain include circulating ligands, which may bepeptides, proteins, or small molecules such as adenosine and the like.For example, growth factors such as EGF, FGF and PDGF are circulatinggrowth factors that bind to their cognate receptors to initiate avariety of cellular responses. Other factors include cytokines,mitogenic factors, neurotrophic factors and the like. Extracellulardomains also bind to cell-associated molecules. In this respect, theymediate cell-cell interactions. Cell-associated ligands can be tetheredto the cell for example via a glycosylphosphatidylinositol (GPI) anchor,or may themselves be transmembrane proteins. Extracellular domains alsoassociate with the extracellular matrix and contribute to themaintenance of the cell structure.

[0088] CA proteins that are transmembrane are particularly preferred inthe present invention as they are good targets for immunotherapeutics,as are described herein. In addition, as outlined below, transmembraneproteins can be also useful in imaging modalities.

[0089] It will also be appreciated by those in the art that atransmembrane protein can be made soluble by removing transmembranesequences, for example through recombinant methods. Furthermore,transmembrane proteins that have been made soluble can be made to besecreted through recombinant means by adding an appropriate signalsequence.

[0090] In a preferred embodiment, the CA proteins are secreted proteins;the secretion of which can be either constitutive or regulated. Theseproteins have a signal peptide or signal sequence that targets themolecule to the secretory pathway. Secreted proteins are involved innumerous physiological events; by virtue of their circulating nature,they serve to transmit signals to various other cell types. The secretedprotein may function in an autocrine manner (acting on the cell thatsecreted the factor), a paracrine manner (acting on cells in closeproximity to the cell that secreted the factor) or an endocrine manner(acting on cells at a distance). Thus secreted molecules find use inmodulating or altering numerous aspects of physiology. CA proteins thatare secreted proteins are particularly preferred in the presentinvention as they serve as good targets for diagnostic markers, forexample for blood tests.

[0091] CA Sequences and Homologs

[0092] A CA sequence is initially identified by substantial nucleic acidand/or amino acid sequence homology to the CA sequences outlined herein.Such homology can be based upon the overall nucleic acid or amino acidsequence, and is generally determined as outlined below, using eitherhomology programs or hybridization conditions.

[0093] As used herein, a nucleic acid is a “CA nucleic acid” if theoverall homology of the nucleic acid sequence to one of the nucleicacids of Tables 1-6 is preferably greater than about 75%, morepreferably greater than about 80%, even more preferably greater thanabout 85% and most preferably greater than 90%. In some embodiments thehomology will be as high as about 93 to 95 or 98%. In a preferredembodiment, the sequences that are used to determine sequence identityor similarity are selected from those of the nucleic acids of Tables1-6. In another embodiment, the sequences are naturally occurringallelic variants of the sequences of the nucleic acids of Tables 1-6. Inanother embodiment, the sequences are sequence variants as furtherdescribed herein.

[0094] Homology in this context means sequence similarity or identity,with identity being preferred. A preferred comparison for homologypurposes is to compare the sequence containing sequencing errors to thecorrect sequence. This homology will be determined using standardtechniques known in the art, including, but not limited to, the localhomology algorithm of Smith & Waterman, Adv. Appl. Math. 2:482 (1981),by the homology alignment algorithm of Needleman & Wunsch, J. Mol. Biol.48:443 (1970), by the search for similarity method of Pearson & Lipman,PNAS USA 85:2444 (1988), by computerized implementations of thesealgorithms (GAP, BESTFIT, FASTA, and TFASTA in the Wisconsin GeneticsSoftware Package, Genetics Computer Group, 575 Science Drive, Madison,Wis.), the Best Fit sequence program described by Devereux et al., Nucl.Acid Res. 12:387-395 (1984), preferably using the default settings, orby inspection.

[0095] One example of a useful algorithm is PILEUP. PILEUP creates amultiple sequence alignment from a group of related sequences usingprogressive, pairwise alignments. It can also plot a tree showing theclustering relationships used to create the alignment. PILEUP uses asimplification of the progressive alignment method of Feng & Doolittle,J. Mol. Evol. 35:351-360 (1987); the method is similar to that describedby Higgins & Sharp CABIOS 5:151-153 (1989). Useful PILEUP parametersinclude a default gap weight of 3.00, a default gap length weight of0.10, and weighted end gaps.

[0096] Another example of a useful algorithm is the BLAST (Basic LocalAlignment Search Tool) algorithm, described in Altschul et al., J. Mol.Biol. 215, 403-410, (1990) and Karlin et al., PNAS USA 90:5873-5787(1993). A particularly useful BLAST program is the WU-BLAST-2 programwhich was obtained from Altschul et al., Methods in Enzymology, 266:460-480 (1996); http://blast.wustl.edu/]. WU-BLAST-2 uses several searchparameters, most of which are set to the default values. The adjustableparameters are set with the following values: overlap span=1, overlapfraction=0.125, word threshold (T)=11. The HSP S and HSP S2 parametersare dynamic values and are established by the program itself dependingupon the composition of the particular sequence and composition of theparticular database against which the sequence of interest is beingsearched; however, the values may be adjusted to increase sensitivity. Apercent amino acid sequence identity value is determined by the numberof matching identical residues divided by the total number of residuesof the “longer” sequence in the aligned region. The “longer” sequence isthe one having the most actual residues in the aligned region (gapsintroduced by WU-Blast-2 to maximize the alignment score are ignored).

[0097] Thus, “percent (%) nucleic acid sequence identity” is defined asthe percentage of nucleotide residues in a candidate sequence that areidentical with the nucleotide residues of the nucleic acids of Tables1-6. A preferred method utilizes the BLASTN module of WU-BLAST-2 set tothe default parameters, with overlap span and overlap fraction set to 1and 0.125, respectively.

[0098] The alignment may include the introduction of gaps in thesequences to be aligned. In addition, for sequences which contain eithermore or fewer nucleotides than those of the nucleic acids of Tables 1-6,it is understood that the percentage of homology will be determinedbased on the number of homologous nucleosides in relation to the totalnumber of nucleosides. Thus homology of sequences shorter than those ofthe sequences identified herein will be determined using the number ofnucleosides in the shorter sequence.

[0099] In another embodiment of the invention, polynucleotidecompositions are provided that are capable of hybridizing under moderateto high stringency conditions to a polynucleotide sequence providedherein, or a fragment thereof, or a complementary sequence thereof.Hybridization techniques are well known in the art of molecular biology.For purposes of illustration, suitable moderately stringent conditionsfor testing the hybridization of a polynucleotide of this invention withother polynucleotides include prewashing in a solution of 5×SSC (“salinesodium citrate”; 9 mM NaCl, 0.9 mM sodium citrate), 0.5% SDS, 1.0 mMEDTA (pH 8.0); hybridizing at 50-60° C., 5×SSC, overnight; followed bywashing twice at 65° C. for 20 minutes with each of 2×, 0.5× and 0.2×SSCcontaining 0.1%-SDS. One skilled in the art will understand that thestringency of hybridization can be readily manipulated, such as byaltering the salt content of the hybridization solution and/or thetemperature at which the hybridization is performed. For example, inanother embodiment, suitable highly stringent hybridization conditionsinclude those described above, with the exception that the temperatureof hybridization is increased, e.g., to 60-65° C., or 65-70° C.Stringent conditions may also be achieved with the addition ofdestabilizing agents such as formamide.

[0100] Thus nucleic acids that hybridize under high stringency to thenucleic acids identified in the figures, or their complements, areconsidered CA sequences. High stringency conditions are known in theart; see for example Maniatis et al., Molecular Cloning: A LaboratoryManual, 2d Edition, 1989, and Short Protocols in Molecular Biology, ed.Ausubel, et al., both of which are hereby incorporated by reference.Stringent conditions are sequence-dependent and will be different indifferent circumstances. Longer sequences hybridize specifically athigher temperatures. An extensive guide to the hybridization of nucleicacids is found in Tijssen, Techniques in Biochemistry and MolecularBiology—Hybridization with Nucleic Acid Probes, “Overview of principlesof hybridization and the strategy of nucleic acid assays” (1993).Generally, stringent conditions are selected to be about 5-10° C. lowerthan the thermal melting point (T_(m)) for the specific sequence at adefined ionic strength pH. The T_(m) is the temperature (under definedionic strength, pH and nucleic acid concentration) at which 50% of theprobes complementary to the target hybridize to the target sequence atequilibrium (as the target sequences are present in excess, at T_(m),50% of the probes are occupied at equilibrium). Stringent conditionswill be those in which the salt concentration is less than about 1.0 Msodium ion, typically about 0.01 to 1.0 M sodium ion concentration (orother salts) at pH 7.0 to 8.3 and the temperature is at least about 30°C. for short probes (e.g. 10 to 50 nucleotides) and at least about 60°C. for longer probes (e.g. greater than 50 nucleotides). In anotherembodiment, less stringent hybridization conditions are used; forexample, moderate or low stringency conditions may be used, as are knownin the art; see Maniatis and Ausubel, supra, and Tijssen, supra.

[0101] In addition, the CA nucleic acid sequences of the invention arefragments of larger genes, i.e. they are nucleic acid segments.Alternatively, the CA nucleic acid sequences can serve as indicators ofoncogene position, for example, the CA sequence may be an enhancer thatactivates a protooncogene. “Genes” in this context includes codingregions, non-coding regions, and mixtures of coding and non-codingregions. Accordingly, as will be appreciated by those in the art, usingthe sequences provided herein, additional sequences of the CA genes canbe obtained, using techniques well known in the art for cloning eitherlonger sequences or the full-length sequences; see Maniatis et al., andAusubel, et al., supra, hereby expressly incorporated by reference. Ingeneral, this is done using PCR, for example, kinetic PCR.

[0102] Detection of CA Expression

[0103] Once the CA nucleic acid is identified, it can be cloned and, ifnecessary, its constituent parts recombined to form the entire CAnucleic acid. Once isolated from its natural source, e.g., containedwithin a plasmid or other vector or excised therefrom as a linearnucleic acid segment, the recombinant CA nucleic acid can be furtherused as a probe to identify and isolate other CA nucleic acids, forexample additional coding regions. It can also be used as a “precursor”nucleic acid to make modified or variant CA nucleic acids and proteins.In a preferred embodiment, once a CA gene is identified its nucleotidesequence is used to design probes specific for the CA gene.

[0104] The CA nucleic acids of the present invention are used in severalways. In a first embodiment, nucleic acid probes hybridizable to CAnucleic acids are made and attached to biochips to be used in screeningand diagnostic methods, or for gene therapy and/or antisenseapplications. Alternatively, the CA nucleic acids that include codingregions of CA proteins can be put into expression vectors for theexpression of CA proteins, again either for screening purposes or foradministration to a patient.

[0105] Recent developments in DNA microarray technology make it possibleto conduct a large scale assay of a plurality of target CA nucleic acidmolecules on a single solid phase support. U.S. Pat. No. 5,837,832 (Cheeet al.) and related patent applications describe immobilizing an arrayof oligonucleotide probes for hybridization and detection of specificnucleic acid sequences in a sample. Target polynucleotides of interestisolated from a tissue of interest are hybridized to the DNA chip andthe specific sequences detected based on the target polynucleotides'preference and degree of hybridization at discrete probe locations. Oneimportant use of arrays is in the analysis of differential geneexpression, where the profile of expression of genes in different cells,often a cell of interest and a control cell, is compared and anydifferences in gene expression among the respective cells areidentified. Such information is useful for the identification of thetypes of genes expressed in a particular cell or tissue type anddiagnosis of cancer conditions based on the expression profile.

[0106] Typically, RNA from the sample of interest is subjected toreverse transcription to obtain labeled cDNA. See U.S. Pat. No.6,410,229 (Lockhart et al.) The cDNA is then hybridized tooligonucleotides or cDNAs of known sequence arrayed on a chip or othersurface in a known order. The location of the oligonucleotide to whichthe labeled cDNA hybridizes provides sequence information on the cDNA,while the amount of labeled hybridized RNA or cDNA provides an estimateof the relative representation of the RNA or(cDNA of interest. SeeSchena, et al. Science 270:467-470 (1995). For example, use of a cDNAmicroarray to analyze gene expression patterns in human cancer isdescribed by DeRisi, et al (Nature Genetics 14:457-460 (1996)).

[0107] In a preferred embodiment, nucleic acid probes corresponding toCA nucleic acids (both the nucleic acid sequences outlined in thefigures and/or the complements thereof) are made. Typically, theseprobes are synthesized based on the disclosed sequences of thisinvention. The nucleic acid probes attached to the biochip are designedto be substantially complementary to the CA nucleic acids, i.e. thetarget sequence (either the target sequence of the sample or to otherprobe sequences, for example in sandwich assays), such that specifichybridization of the target sequence and the probes of the presentinvention occurs. As outlined below, this complementarity need not beperfect, in that there may be any number of base pair mismatches thatwill interfere with hybridization between the target sequence and thesingle stranded nucleic acids of the present invention. It is expectedthat the overall homology of the genes at the nucleotide level probablywill be about 40% or greater, probably about 60% or greater, and evenmore probably about 80% or greater; and in addition that there will becorresponding contiguous sequences of about 8-12 nucleotides or longer.However, if the number of mutations is so great that no hybridizationcan occur under even the least stringent of hybridization conditions,the sequence is not a complementary target sequence. Thus, by“substantially complementary” herein is meant that the probes aresufficiently complementary to the target sequences to hybridize undernormal reaction conditions, particularly high stringency conditions, asoutlined herein. Whether or not a sequence is unique to a CA geneaccording to this invention can be determined by techniques known tothose of skill in the art. For example, the sequence can be compared tosequences in databanks, e.g., GeneBank, to determine whether it ispresent in the uninfected host or other organisms. The sequence can alsobe compared to the known sequences of other viral agents, includingthose that are known to induce cancer.

[0108] A nucleic acid probe is generally single stranded but can bepartly single and partly double stranded. The strandedness of the probeis dictated by the structure, composition, and properties of the targetsequence. In general, the oligonucleotide probes range from about 6, 8,10, 12, 15, 20, 30 to about 100 bases long, with from about 10 to about80 bases being preferred, and from about 30 to about 50 bases beingparticularly preferred. That is, generally entire genes are rarely usedas probes. In some embodiments, much longer nucleic acids can be used,up to hundreds of bases. The probes are sufficiently specific tohybridize to complementary template sequence under conditions known bythose of skill in the art. The number of mismatches between the probessequences and their complementary template (target) sequences to whichthey hybridize during hybridization generally do not exceed 15%, usuallydo not exceed 10% and preferably do not exceed 5%, as determined byFASTA (default settings).

[0109] Oligonucleotide probes can include the naturally-occurringheterocyclic bases normally found in nucleic acids (uracil, cytosine,thymine, adenine and guanine), as well as modified bases and baseanalogues. Any modified base or base analogue compatible withhybridization of the probe to a target sequence is useful in thepractice of the invention. The sugar or glycoside portion of the probecan comprise deoxyribose, ribose, and/or modified forms of these sugars,such as, for example, 2′-O-alkyl ribose. In a preferred embodiment, thesugar moiety is 2′-deoxyribose; however, any sugar moiety that iscompatible with the ability of the probe to hybridize to a targetsequence can be used.

[0110] In one embodiment, the nucleoside units of the probe are linkedby a phosphodiester backbone, as is well known in the art. In additionalembodiments, internucleotide linkages can include any linkage known toone of skill in the art that is compatible with specific hybridizationof the probe including, but not limited to phosphorothioate,methylphosphonate, sulfamate (e.g., U.S. Pat. No. 5,470,967) andpolyamide (i.e., peptide nucleic acids). Peptide nucleic acids aredescribed in Nielsen et al. (1991) Science 254: 1497-1500, U.S. Pat. No.5,714,331, and Nielsen (1999) Curr. Opin. Biotechnol. 10:71-75.

[0111] In certain embodiments, the probe can be a chimeric molecule;i.e., can comprise more than one type of base or sugar subunit, and/orthe linkages can be of more than one type within the same primer. Theprobe can comprise a moiety to facilitate hybridization to its targetsequence, as are known in the art, for example, intercalators and/orminor groove binders. Variations of the bases, sugars, andinternucleoside backbone, as well as the presence of any pendant groupon the probe, will be compatible with the ability of the probe to bind,in a sequence-specific fashion, with its target sequence. A large numberof structural modifications, both known and to be developed, arepossible within these bounds. Advantageously, the probes according tothe present invention may have structural characteristics such that theyallow the signal amplification, such structural characteristics being,for example, branched DNA probes as those described by Urdea et al.(Nucleic Acids Symp. Ser., 24:197-200 (1991)) or in the European PatentNo. EP-0225,807. Moreover, synthetic methods for preparing the variousheterocyclic bases, sugars, nucleosides and nucleotides that form theprobe, and preparation of oligonucleotides of specific predeterminedsequence, are well-developed and known in the art. A preferred methodfor oligonucleotide synthesis incorporates the teaching of U.S. Pat. No.5,419,966.

[0112] Multiple probes may be designed for a particular target nucleicacid to account for polymorphism and/or secondary structure in thetarget nucleic acid, redundancy of data and the like. In someembodiments, where more than one probe per sequence is used, eitheroverlapping probes or probes to different sections of a single target CAgene are used. That is, two, three, four or more probes, with threebeing preferred, are used to build in a redundancy for a particulartarget. The probes can be overlapping (i.e. have some sequence incommon), or specific for distinct sequences of a CA gene. When multipletarget polynucleotides are to be detected according to the presentinvention, each probe or probe group corresponding to a particulartarget polynucleotide is situated in a discrete area of the microarray.

[0113] Probes may be in solution, such as in wells or on the surface ofa micro-array, or attached to a solid support. Examples of solid supportmaterials that can be used include a plastic, a ceramic, a metal, aresin, a gel and a membrane. Useful types of solid supports includeplates, beads, magnetic material, microbeads, hybridization chips,membranes, crystals, ceramics and self-assembling monolayers. Apreferred embodiment comprises a two-dimensional or three-dimensionalmatrix, such as a gel or hybridization chip with multiple probe bindingsites (Pevzner et al., J. Biomol. Struc. & Dyn. 9:399-410, 1991; Maskosand Southern, Nuc. Acids Res. 20:1679-84, 1992). Hybridization chips canbe used to construct very large probe arrays that are subsequentlyhybridized with a target nucleic acid. Analysis of the hybridizationpattern of the chip can assist in the identification of the targetnucleotide sequence. Patterns can be manually or computer analyzed, butit is clear that positional sequencing by hybridization lends itself tocomputer analysis and automation. Algorithms and software, which havebeen developed for sequence reconstruction, are applicable to themethods described herein (R. Drmanac et al., J. Biomol. Struc. & Dyn.5:1085-1102, 1991; P. A. Pevzner, J. Biomol. Struc. & Dyn. 7:63-73,1989).

[0114] As will be appreciated by those in the art, nucleic acids can beattached or immobilized to a solid support in a wide variety of ways. By“immobilized” herein is meant the association or binding between thenucleic acid probe and the solid support is sufficient to be stableunder the conditions of binding, washing, analysis, and removal asoutlined below. The binding can be covalent or non-covalent. By“non-covalent binding” and grammatical equivalents herein is meant oneor more of either electrostatic, hydrophilic, and hydrophobicinteractions. Included in non-covalent binding is the covalentattachment of a molecule, such as streptavidin, to the support and thenon-covalent binding of the biotinylated probe to the streptavidin. By“covalent binding” and grammatical equivalents herein is meant that thetwo moieties, the solid support and the probe, are attached by at leastone bond, including sigma bonds, pi bonds and coordination bonds.Covalent bonds can be formed directly between the probe and the solidsupport or can be formed by a cross linker or by inclusion of a specificreactive group on either the solid support or the probe or bothmolecules. Immobilization may also involve a combination of covalent andnon-covalent interactions.

[0115] Nucleic acid probes may be attached to the solid support bycovalent binding such as by conjugation with a coupling agent or by,covalent or non-covalent binding such as electrostatic interactions,hydrogen bonds or antibody-antigen coupling, or by combinations thereof.Typical coupling agents include biotin/avidin, biotin/streptavidin,Staphylococcus aureus protein A/IgG antibody Fc fragment, andstreptavidin/protein A chimeras (T. Sano and C. R. Cantor,Bio/Technology 9:1378-81 (1991)), or derivatives or combinations ofthese agents. Nucleic acids may be attached to the solid support by aphotocleavable bond, an electrostatic bond, a disulfide bond, a peptidebond, a diester bond or a combination of these sorts of bonds. The arraymay also be attached to the solid support by a selectively releasablebond such as. 4,4′-dimethoxytrityl or its derivative. Derivatives whichhave been found to be useful include 3 or 4[bis-(4-methoxyphenyl)]-methyl-benzoic acid, N-succinimidyl-3 or 4[bis-(4-methoxyphenyl)]-methyl-benzoic acid, N-succinimidyl-3 or 4[bis-(4-methoxyphenyl)]-hydroxymethyl-benzoic acid, N-succinimidyl-3 or4 [bis-(4-methoxyphenyl)]-chloromethyl-benzoic acid, and salts of theseacids.

[0116] In general, the probes are attached to the biochip in a widevariety of ways, as will be appreciated by those in the art. Asdescribed herein, the nucleic acids can either be synthesized first,with subsequent attachment to the biochip, or can be directlysynthesized on the biochip.

[0117] The biochip comprises a suitable solid substrate. By “substrate”or “solid support” or other grammatical equivalents herein is meant anymaterial that can be modified to contain discrete individual sitesappropriate for the attachment or association of the nucleic acid probesand is amenable to at least one detection method. The solid phasesupport of the present invention can be of any solid materials andstructures suitable for supporting nucleotide hybridization andsynthesis. Preferably, the solid phase support comprises at least onesubstantially rigid surface on which the primers can be immobilized andthe reverse transcriptase reaction performed. The substrates with whichthe polynucleotide microarray elements are stably associated may befabricated from a variety of materials, including plastics, ceramics,metals, acrylamide, cellulose, nitrocellulose, glass, polystyrene,polyethylene vinyl acetate, polypropylene, polymethacrylate,polyethylene, polyethylene oxide, polysilicates, polycarbonates,Teflon®, fluorocarbons, nylon, silicon rubber, polyanhydrides,polyglycolic acid, polylactic acid, polyorthoesters, polypropylfumerate,collagen, glycosaminoglycans, and polyamino acids. Substrates may betwo-dimensional or three-dimensional in form, such as gels, membranes,thin films, glasses, plates, cylinders, beads, magnetic beads, opticalfibers, woven fibers, etc. A preferred form of array is athree-dimensional array. A preferred three-dimensional array is acollection of tagged beads. Each tagged bead has different primersattached to it. Tags are detectable by signaling means such as color(Luminex, Illumina) and electromagnetic field (Pharmaseq) and signals ontagged beads can even be remotely detected (e.g., using optical fibers).The size of the solid support can be any of the standard microarraysizes, useful for DNA microarray technology, and the size may betailored to fit the particular machine being used to conduct a reactionof the invention. In general, the substrates allow optical detection anddo not appreciably fluoresce.

[0118] In a preferred embodiment, the surface of the biochip and theprobe may be derivatized with chemical functional groups for subsequentattachment of the two. Thus, for example, the biochip is derivatizedwith a chemical functional group including, but not limited to, aminogroups, carboxy groups, oxo groups and thiol groups, with amino groupsbeing particularly preferred. Using these functional groups, the probescan be attached using functional groups on the probes. For example,nucleic acids containing amino groups can be attached to surfacescomprising amino groups, for example using linkers as are known in theart; for example, homo-or hetero-bifunctional linkers as are well known(see 1994 Pierce Chemical Company catalog, technical section oncross-linkers, pages 155-200, incorporated herein by reference). Inaddition, in some cases, additional linkers, such as alkyl groups(including substituted and heteroalkyl groups) may be used.

[0119] In this embodiment, the oligonucleotides are synthesized as isknown in the art, and then attached to the surface of the solid support.As will be appreciated by those skilled in the art, either the 5′ or 3′terminus may be attached to the solid support, or attachment may be viaan internal nucleoside. In an additional embodiment, the immobilizationto the solid support may be very strong, yet non-covalent. For example,biotinylated oligonucleotides can be made, which bind to surfacescovalently coated with streptavidin, resulting in attachment.

[0120] The arrays may be produced according to any convenientmethodology, such as, preforming the polynucleotide microarray elementsand then stably associating them with the surface. Alternatively, theoligonucleotides may be synthesized on the surface, as is known in theart. A number of different array configurations and methods for theirproduction are known to those of skill in the art and disclosed in WO95/25116 and WO 95/35505 (photolithographic techniques), U.S. Pat. No.5,445,934 (in situ synthesis by photolithography), U.S. Pat. No.5,384,261 (in situ synthesis by mechanically directed flow paths); andU.S. Pat. No. 5,700,637 (synthesis by spotting, printing or coupling);the disclosure of which are herein incorporated in their entirety byreference. Another method for coupling DNA to beads uses specificligands attached to the end of the DNA to link to ligand-bindingmolecules attached to a bead. Possible ligand-binding partner pairsinclude biotin-avidin/streptavidin, or various antibody/antigen pairssuch as digoxygenin-antidigoxygenin antibody (Smith et al., “DirectMechanical Measurements of the Elasticity of Single DNA Molecules byUsing Magnetic Beads,” Science 258:1122-1126 (1992)). Covalent chemicalattachment of DNA to the support can be accomplished by using standardcoupling agents to link the 5′-phosphate on the DNA to coatedmicrospheres through a phosphoamidate bond. Methods for immobilizationof oligonucleotides to solid-state substrates are well established. SeePease et al., Proc. Natl. Acad. Sci. USA 91(11):5022-5026 (1994). Apreferred method of attaching oligonucleotides to solid-state substratesis described by Guo et al., Nucleic Acids Res. 22:5456-5465 (1994).Immobilization can be accomplished either by in situ DNA synthesis(Maskos and Southern, Nucleic Acids Research, 20:1679-1684 (1992) or bycovalent attachment of chemically synthesized oligonucleotides (Guo etal., supra) in combination with robotic arraying technologies.

[0121] In addition to the solid-phase technology represented by biochiparrays, gene expression can also be quantified using liquid-phasearrays. One such system is kinetic polymerase chain reaction (PCR).Kinetic PCR allows for the simultaneous amplification and quantificationof specific nucleic acid sequences. The specificity is derived fromsynthetic oligonucleotide primers designed to preferentially adhere tosingle-stranded nucleic acid sequences bracketing the target site. Thispair of oligonucleotide primers form specific, non-covalently boundcomplexes on each strand of the target sequence. These complexesfacilitate in vitro transcription of double-stranded DNA in oppositeorientations. Temperature cycling of the reaction mixture creates acontinuous cycle of primer binding, transcription, and re-melting of thenucleic acid to individual strands. The result is an exponentialincrease of the target dsDNA product. This product can be quantified inreal time either through the use of an intercalating dye or a sequencespecific probe. SYBR® Greene I, is an example of an intercalating dye,that preferentially binds to dsDNA resulting in a concomitant increasein the fluorescent signal. Sequence specific probes, such as used withTaqMan® technology, consist of a fluorochrome and a quenching moleculecovalently bound to opposite ends of an oligonucleotide. The probe isdesigned to selectively bind the target DNA sequence between the twoprimers. When the DNA strands are synthesized during the PCR reaction,the fluorochrome is cleaved from the probe by the exonuclease activityof the polymerase resulting in signal dequenching. The probe signalingmethod can be more specific than the intercalating dye method, but ineach case, signal strength is proportional to the dsDNA productproduced. Each type of quantification method can be used in multi-wellliquid phase arrays with each well representing primers and/or probesspecific to nucleic acid sequences of interest. When used with messengerRNA preparations of tissues or cell lines, an array of probe/primerreactions can simultaneously quantify the expression of multiple geneproducts of interest. See Germer, S., et al., Genome Res. 10:258-266(2000); Heid, C. A., et al., Genome Res. 6, 986-994 (1996).

[0122] Expression of CA Proteins

[0123] In a preferred embodiment, CA nucleic acids encoding CA proteinsare used to make a variety of expression vectors to express CA proteinswhich can then be used in screening assays, as described below. Theexpression vectors may be either self-replicating extrachromosomalvectors or vectors which integrate into a host genome. Generally, theseexpression vectors include transcriptional and translational regulatorynucleic acid operably linked to the nucleic acid encoding the CAprotein. The term “control sequences” refers to DNA sequences necessaryfor the expression of an operably linked coding sequence in a particularhost organism. The control sequences that are suitable for prokaryotes,for example, include a promoter, optionally an operator sequence, and aribosome binding site. Eukaryotic cells are known to utilize promoters,polyadenylation signals, and enhancers.

[0124] Nucleic acid is “operably linked” when it is placed into afunctional relationship with another nucleic acid sequence. For example,DNA for a presequence or secretory leader is operably linked to DNA fora polypeptide if it is expressed as a preprotein that participates inthe secretion of the polypeptide; a promoter or enhancer is operablylinked to a coding sequence if it affects the transcription of thesequence; or a ribosome binding site is operably linked to a codingsequence if it is positioned so as to facilitate translation. Generally,“operably linked” means that the DNA sequences being linked arecontiguous, and, in the case of a secretory leader, contiguous and inreading phase. However, enhancers do not have to be contiguous. Linkingis accomplished by ligation at convenient restriction sites. If suchsites do not exist, synthetic oligonucleotide adaptors or linkers areused in accordance with conventional practice. The transcriptional andtranslational regulatory nucleic acid will generally be appropriate tothe host cell used to express the CA protein; for example,transcriptional and translational regulatory nucleic acid sequences fromBacillus are preferably used to express the CA protein in Bacillus.Numerous types of appropriate expression vectors, and suitableregulatory sequences are known in the art for a variety of host cells.

[0125] In general, the transcriptional and translational regulatorysequences may include, but are not limited to, promoter sequences,ribosomal binding sites, transcriptional start and stop sequences,translational start and stop sequences, and enhancer or activatorsequences. In a preferred embodiment, the regulatory sequences include apromoter and transcriptional start and stop sequences.

[0126] Promoter sequences encode either constitutive or induciblepromoters. The promoters may be either naturally occurring promoters orhybrid promoters. Hybrid promoters, which combine elements of more thanone promoter, are also known in the art, and are useful in the presentinvention.

[0127] In addition, the expression vector may comprise additionalelements. For example, the expression vector may have two replicationsystems, thus allowing it to be maintained in two organisms, for examplein mammalian or insect cells for expression; and in a prokaryotic hostfor cloning and amplification. Furthermore, for integrating expressionvectors, the expression vector contains at least one sequence homologousto the host cell genome, and preferably two homologous sequences thatflank the expression construct. The integrating vector may be directedto a specific locus in the host cell by selecting the appropriatehomologous sequence for inclusion in the vector. Constructs forintegrating vectors are well known in the art.

[0128] In addition, in a preferred embodiment, the expression vectorcontains a selectable marker gene to allow the selection of transformedhost cells. Selection genes are well known in the art and will vary withthe host cell used.

[0129] The CA proteins of the present invention are produced byculturing a host cell transformed with an expression vector containingnucleic acid encoding a CA protein, under the appropriate conditions toinduce or cause expression of the CA protein. The conditions appropriatefor CA protein expression will vary with the choice of the expressionvector and the host cell, and will be easily ascertained by one skilledin the art through routine experimentation. For example, the use ofconstitutive promoters in the expression vector will require optimizingthe growth and proliferation of the host cell, while the use of aninducible promoter requires the appropriate growth conditions forinduction. In addition, in some embodiments, the timing of the harvestis important. For example, the baculoviral systems used in insect cellexpression are lytic viruses, and thus harvest time selection can becrucial for product yield.

[0130] Appropriate host cells include yeast, bacteria, archaebacteria,fungi, and insect, plant and animal cells, including mammalian cells. Ofparticular interest are Drosophila melanogaster cells, Saccharomycescerevisiae and other yeasts, E. coli, Bacillus subtilis, Sf9 cells, C129cells, 293 cells, Neurospora, BHK, CHO, COS, HeLa cells, THP1 cell line(a macrophage cell line) and human cells and cell lines.

[0131] In a preferred embodiment, the CA proteins are expressed inmammalian cells. Mammalian expression systems are also known in the art,and include retroviral systems. A preferred expression vector system isa retroviral vector system such as is generally described inPCT/US97/01019 and PCT/US97/01048, both of which are hereby expresslyincorporated by reference. Of particular use as mammalian promoters arethe promoters from mammalian viral genes, since the viral genes areoften highly expressed and have a broad host range. Examples include theSV40 early promoter, mouse mammary tumor virus LTR promoter, adenovirusmajor late promoter, herpes simplex virus promoter, and the CMVpromoter. Typically, transcription termination and polyadenylationsequences recognized by mammalian cells are regulatory regions located3′ to the translation stop codon and thus, together with the promoterelements, flank the coding sequence. Examples of transcriptionterminator and polyadenylation signals include those derived form SV40.

[0132] The methods of introducing exogenous nucleic acid into mammalianhosts, as well as other hosts, are well known in the art, and will varywith the host cell used. Techniques include dextran-mediatedtransfection, calcium phosphate precipitation, polybrene mediatedtransfection, protoplast fusion, electroporation, viral infection,encapsulation of the polynucleotide(s) in liposomes, and directmicroinjection of the DNA into nuclei.

[0133] In a preferred embodiment, CA proteins are expressed in bacterialsystems. Bacterial expression systems are well known in the art.Promoters from bacteriophage may also be used and are known in the art.In addition, synthetic promoters and hybrid promoters are also useful;for example, the tac promoter is a hybrid of the trp and lac promotersequences. Furthermore, a bacterial promoter can include naturallyoccurring promoters of non-bacterial origin that have the ability tobind bacterial RNA polymerase and initiate transcription. In addition toa functioning promoter sequence, an efficient ribosome binding site isdesirable. The expression vector may also include a signal peptidesequence that provides for secretion of the CA protein in bacteria. Theprotein is either secreted into the growth media (gram-positivebacteria) or into the periplasmic space, located between the inner andouter membrane of the cell (gram-negative bacteria). The bacterialexpression vector may also include a selectable marker gene to allow forthe selection of bacterial strains that have been transformed. Suitableselection genes include genes that render the bacteria resistant todrugs such as ampicillin, chloramphenicol, erythromycin, kanamycin,neomycin and tetracycline. Selectable markers also include biosyntheticgenes, such as those in the histidine, tryptophan and leucinebiosynthetic pathways. These components are assembled into expressionvectors. Expression vectors for bacteria are well known in the art, andinclude vectors for Bacillus subtilis, E. coli, Streptococcus cremoris,and Streptococcus lividans, among others. The bacterial expressionvectors are transformed into bacterial host cells using techniques wellknown in the art, such as calcium chloride treatment, electroporation,and others.

[0134] In one embodiment, CA proteins are produced in insect cells.Expression vectors for the transformation of insect cells, and inparticular, baculovirus-based expression vectors, are well known in theart.

[0135] In a preferred embodiment, CA protein is produced in yeast cells.Yeast expression systems are well known in the art, and includeexpression vectors for Saccharomyces cerevisiae, Candida albicans and C.maltosa, Hansenula polymorpha, Kluyveromyces fragilis and K. lactis,Pichia guillerimondii and P. pastoris, Schizosaccharomyces pombe, andYarrowia lipolytica.

[0136] The CA protein may also be made as a fusion protein, usingtechniques well known in the art. Thus, for example, for the creation ofmonoclonal antibodies. If the desired epitope is small, the CA proteinmay be fused to a carrier protein to form an immunogen. Alternatively,the CA protein may be made as a fusion protein to increase expression,or for other reasons. For example, when the CA protein is a CA peptide,the nucleic acid encoding the peptide may be linked to other nucleicacid for expression purposes.

[0137] In one embodiment, the CA nucleic acids, proteins and antibodiesof the invention are labeled. By “labeled” herein is meant that acompound has at least one element, isotope or chemical compound attachedto enable the detection of the compound. In general, labels fall intothree classes: a) isotopic labels, which may be radioactive or heavyisotopes; b) immune labels, which may be antibodies or antigens; and c)colored or fluorescent dyes. The labels may be incorporated into the CAnucleic acids, proteins and antibodies at any position. For example, thelabel should be capable of producing, either directly or indirectly, adetectable signal. The detectable moiety may be a radioisotope, such as³H, ¹⁴C, ₃₂P, ³⁵S, or ¹²⁵I, a fluorescent or chemiluminescent compound,such as fluorescein: isothiocyanate, rhodamine, or luciferin, or anenzyme, such as alkaline phosphatase, beta-galactosidase or horseradishperoxidase. Any method known in the art for conjugating the antibody tothe label may be employed, including those methods described by Hunteret al., Nature, 144:945 (1962); David et al., Biochemistry, 13:1014(1974); Pain et al., J. Immunol. Meth., 40:219 (1981); and Nygren, J.Histochem. and Cytochem., 30:407 (1982).

[0138] Accordingly, the present invention also provides CA proteinsequences. A CA protein of the present invention may be identified inseveral ways. “Protein” in this sense includes proteins, polypeptides,and peptides. As will be appreciated by those in the art, the nucleicacid sequences of the invention can be used to generate proteinsequences. There are a variety of ways to do this, including cloning theentire gene and verifying its frame and amino acid sequence, or bycomparing it to known sequences to search for homology to provide aframe, assuming the CA protein has homology to some protein in thedatabase being used. Generally, the nucleic acid sequences are inputinto a program that will search all three frames for homology. This isdone in a preferred embodiment using the following NCBI Advanced BLASTparameters. The program is blastx or blastn. The database is nr. Theinput data is as “Sequence in FASTA format”. The organism list is“none”. The “expect” is 10; the filter is default. The “descriptions” is500, the “alignments” is 500, and the “alignment view” is pairwise. The“query Genetic Codes” is standard (1). The matrix is BLOSUM 62; gapexistence cost is 11, per residue gap cost is 1; and the lambda ratio is0.85 default. This results in the generation of a putative proteinsequence.

[0139] In general, the term “polypeptide” as used herein refers to boththe full-length polypeptide encoded by the recited polynucleotide, thepolypeptide encoded by the gene represented by the recitedpolynucleotide, as well as portions or fragments thereof. The presentinvention encompasses variants of the naturally occurring proteins,wherein such variants are homologous or substantially similar to thenaturally occurring protein, and can be of an origin of the same ordifferent species as the naturally occurring protein (e.g., human,murine, or some other species that naturally expresses the recitedpolypeptide, usually a mammalian species). In general, variantpolypeptides have a sequence that has at least about 80%, at least about81%, at least about 82%, at least about 83%, at least about 84%, atleast about 85%, at least about 86%, at least about 87%, at least about88%, at least about 89%, usually at least about 90%, at least 91%, atleast 92%, at least 93%, at least 94%, at least 95%, at least 96%, atleast 97%, at least 98% and more usually at least about 99% sequenceidentity with a differentially expressed polypeptide described herein,as determined by the Smith-Waterman homology search algorithm using anaffine gap search with a gap open penalty of 12 and a gap extensionpenalty of 2, BLOSUM matrix of 62. The Smith-Waterman homology searchalgorithm is taught in Smith and Waterman, Adv. Appl. Math. (1981) 2:482-489. The variant polypeptides can be naturally or non-naturallyglycosylated, i.e., the polypeptide has a glycosylation pattern thatdiffers from the glycosylation pattern found in the correspondingnaturally occurring protein.

[0140] Also within the scope of the invention are variants. Variants ofpolypeptides include mutants, fragments, and fusions. Mutants caninclude amino acid substitutions, additions or deletions. The amino acidsubstitutions can be conservative amino acid substitutions orsubstitutions to eliminate non-essential amino acids, such as to alter aglycosylation site, a phosphorylation site or an acetylation site, or tominimize misfolding by substitution or deletion of one or more cysteineresidues that are not necessary for function. Conservative amino acidsubstitutions are those that preserve the general charge,hydrophobicity/hydrophilicity, and/or steric bulk of the amino acidsubstituted. Variants can be designed so as to retain or have enhancedbiological activity of a particular region of the protein (e.g., afunctional domain and/or, where the polypeptide is a member of a proteinfamily, a region associated with a consensus sequence). Selection ofamino acid alterations for production of variants can be based upon theaccessibility (interior vs. exterior) of the amino acid (see, e.g., Goet al, Int. J. Peptide Protein Res. (1980) 15:211), the thermostabilityof the variant polypeptide (see, e.g., Querol et al., Prot. Eng. (1996)9:265), desired glycosylation sites (see, e.g., Olsen and Thomsen, J.Gen. Microbiol. (1991) 137:579), desired disulfide bridges (see, e.g.,Clarke et al., Biochemistry (1993) 32:4322; and Wakarchuk et al.,Protein Eng. (1994) 7:1379), desired metal binding sites (see, e.g.,Toma et al., Biochemistry (1991) 30:97, and Haezerbrouck et al., ProteinEng. (1993) 6:643), and desired substitutions within proline loops (see,e.g., Masul et al., Appl. Env. Microbiol. (1994) 60:3579).Cysteine-depleted muteins can be produced as disclosed in U.S. Pat. No.4,959,314.

[0141] Variants also include fragments of the polypeptides disclosedherein, particularly biologically active fragments and/or fragmentscorresponding to functional domains. Fragments of interest willtypically be at least about 8 amino acids (aa) 10 aa, 15 aa, 20 aa, 25aa, 30 aa, 35 aa, 40 aa, to at least about 45 aa in length, usually atleast about 50 aa in length, at least about 75 aa, at least about 100aa, at least about 125 aa, at least about 150 aa in length, at leastabout 200 aa, at least about 300 aa, at least about 400 aa and can be aslong as 500 aa in length or longer, but will usually not exceed about1000 aa in length, where the fragment will have a stretch of amino acidsthat is identical to a polypeptide encoded by a polynucleotide having asequence of any one of the polynucleotide sequences provided herein, ora homolog thereof. The protein variants described herein are encoded bypolynucleotides that are within the scope of the invention. The geneticcode can be used to select the appropriate codons to construct thecorresponding variants.

[0142] While altered expression of the polynucleotides associated withcancer is observed, altered levels of expression of the polypeptidesencoded by these polynucleotides may likely play a role in cancers.

[0143] Also included within one embodiment of CA proteins are amino acidvariants of the naturally occurring sequences, as determined herein.Preferably, the variants are preferably greater than about 75%homologous to the wild-type sequence, more preferably greater than about80%, even more preferably greater than about 85% and most preferablygreater than 90%. The present application is also directed to proteinscontaining polypeptides at least 80%, 85%, 90%, 95%, 96%, 97%, 98% or99% identical to a CA polypeptide sequence set forth herein. As fornucleic acids, homology in this context means sequence similarity oridentity, with identity being preferred. This homology will bedetermined using standard techniques known in the art as are outlinedabove for the nucleic acid homologies.

[0144] CA proteins of the present invention may be shorter or longerthan the wild type amino acid sequences. Thus, in a preferredembodiment, included within the definition of CA proteins are portionsor fragments of the wild type sequences herein. In addition, as outlinedabove, the CA nucleic acids of the invention may be used to obtainadditional coding regions, and thus additional protein sequence, usingtechniques known in the art.

[0145] In a preferred embodiment, the CA proteins are derivative orvariant CA proteins as compared to the wild-type sequence. That is, asoutlined more fully below, the derivative CA peptide will contain atleast one amino acid substitution, deletion or insertion, with aminoacid substitutions being particularly preferred. The amino acidsubstitution, insertion or deletion may occur at any residue within theCA peptide.

[0146] Also included in an embodiment of CA proteins of the presentinvention are amino acid sequence variants. These variants fall into oneor more of three classes: substitutional, insertional or deletionalvariants. These variants ordinarily are prepared by site-specificmutagenesis of nucleotides in the DNA encoding the CA protein, usingcassette or PCR mutagenesis or other techniques well known in the art,to produce DNA encoding the variant, and thereafter expressing the DNAin recombinant cell culture as outlined above. However, variant CAprotein fragments having up to about 100-150 residues may be prepared byin vitro synthesis using established techniques. Amino acid sequencevariants are characterized by the predetermined nature of the variation,a feature that sets them apart from naturally occurring allelic orinterspecies variation of the CA protein amino acid sequence. Thevariants typically exhibit the same qualitative biological activity asthe naturally occurring analogue, although variants can also be selectedwhich have modified characteristics as will be more fully outlinedbelow.

[0147] While the site or region for introducing an amino acid sequencevariation is predetermined, the mutation per se need not bepredetermined. For example, in order to optimize the performance of amutation at a given site, random mutagenesis may be conducted at thetarget codon or region and the expressed CA variants screened for theoptimal combination of desired activity. Techniques for makingsubstitution mutations at predetermined sites in DNA having a knownsequence are well known, for example, M13 primer mutagenesis and LARmutagenesis. Screening of the mutants is done using assays of CA proteinactivities.

[0148] Amino acid substitutions are typically of single residues;insertions usually will be on the order of from about 1 to 20 aminoacids, although considerably larger insertions may be tolerated.Deletions range from about 1 to about 20 residues, although in somecases deletions may be much larger.

[0149] Substitutions, deletions, insertions or any combination thereofmay be used to arrive at a final derivative. Generally these changes aredone on a few amino acids to minimize the alteration of the molecule.However, larger changes may be tolerated in certain circumstances. Whensmall alterations in the characteristics of the CA protein are desired,substitutions are generally made in accordance with the following chart:CHART 1 Original Residue Exemplary Substitutions Ala Ser Arg Lys AsnGln, His Asp Glu Cys Ser Gln Asn Glu Asp Gly Pro His Asn, Gln Ile Leu,Val Leu Ile, Val Lys Arg, Gln, Glu Met Leu, Ile Phe Met, Leu, Tyr SerThr Thr Ser Trp Tyr Tyr Trp, Phe Val Ile, Leu

[0150] Substantial changes in function or immunological identity aremade by selecting substitutions that are less conservative than thoseshown in Chart I. For example, substitutions may be made full length tomore significantly affect one or more of the following: the structure ofthe polypeptide backbone in the area of the alteration (e.g., thealpha-helical or beta-sheet structure); the charge or hydrophobicity ofthe molecule at the target site; and the bulk of the side chain. Thesubstitutions which in general are expected to produce the greatestchanges in the polypeptide's properties are those in which (a) ahydrophilic residue, e.g. seryl or threonyl is substituted for (or by) ahydrophobic residue, e.g. leucyl, isoleucyl, phenylalanyl, valyl oralanyl; (b) a cysteine or proline is substituted for (or by) any otherresidue; (c) a residue having an electropositive side chain, e.g. lysyl,arginyl, or histidyl, is substituted for (or by) an electronegativeresidue, e.g. glutamyl or aspartyl; or (d) a residue having a bulky sidechain, e.g. phenylalanine, is substituted for (or by) one not having aside chain, e.g. glycine.

[0151] The variants typically exhibit the same qualitative biologicalactivity and will elicit the same immune response as thenaturally-occurring analogue, although variants also are selected tomodify the characteristics of the CA proteins as needed. Alternatively,the variant may be designed such that the biological activity of the CAprotein is altered. For example, glycosylation sites may be altered orremoved, dominant negative mutations created, etc.

[0152] Covalent modifications of CA polypeptides are included within thescope of this invention, for example for use in screening. One type ofcovalent modification includes reacting targeted amino acid residues ofa CA polypeptide with an organic derivatizing agent that is capable ofreacting with selected side chains or the N- or C-terminal residues of aCA polypeptide. Derivatization with bifunctional agents is useful, forinstance, for crosslinking CA polypeptides to a water-insoluble supportmatrix or surface for use in the method for purifying anti-CA antibodiesor screening assays, as is more fully described below. Commonly usedcrosslinking agents include, e.g., 1,1-bis(diazoacetyl)-2-phenylethane,glutaraldehyde, N-hydroxysuccinimide esters, for example, esters with4-azidosalicylic acid, homobifunctional imidoesters, includingdisuccinimidyl esters such as 3,3′-dithiobis(succinimidylpropionate),bifunctional maleimides such as bis-N-maleimido-1,8-octane and agentssuch as methyl-3-[(p-azidophenyl)dithio]propioimidate.

[0153] Other modifications include deamidation of glutaminyl andasparaginyl residues to the corresponding glutamyl and aspartylresidues, respectively, hydroxylation of proline and lysine,phosphorylation of hydroxyl groups of seryl, threonyl or tyrosylresidues, methylation of the a-amino groups of lysine, arginine, andhistidine side chains [T. E. Creighton, Proteins: Structure andMolecular Properties, W. H. Freeman & Co., San Francisco, pp. 79-86(1983)], acetylation of the N-terminal amine, and amidation of anyC-terminal carboxyl group.

[0154] Another type of covalent modification of the CA polypeptideincluded within the scope of this invention comprises altering thenative glycosylation pattern of the polypeptide. “Altering the nativeglycosylation pattern” is intended for purposes herein to mean deletingone or more carbohydrate moieties found in native sequence CApolypeptide, and/or adding one or more glycosylation sites that are notpresent in the native sequence CA polypeptide.

[0155] Addition of glycosylation sites to CA polypeptides may beaccomplished by altering the amino acid sequence thereof. The alterationmay be made, for example, by the addition of, or substitution by, one ormore serine or threonine residues to the native sequence CA polypeptide(for O-linked glycosylation sites). The CA amino acid sequence mayoptionally be altered through changes at the DNA level, particularly bymutating the DNA encoding the CA polypeptide at preselected bases suchthat codons are generated that will translate into the desired aminoacids.

[0156] Another means of increasing the number of carbohydrate moietieson the CA polypeptide is by chemical or enzymatic coupling of glycosidesto the polypeptide. Such methods are described in the art, e.g., in WO87/05330 published Sep. 11, 1987, and in Aplin and Wriston, LA Crit.Rev. Biochem., pp. 259-306 (1981).

[0157] Removal of carbohydrate moieties present on the CA polypeptidemay be accomplished chemically or enzymatically or by mutationalsubstitution of codons encoding for amino acid residues that serve astargets for glycosylation. Chemical deglycosylation techniques are knownin the art and described, for instance, by Hakimuddin, et al., Arch.Biochem. Biophys., 259:52 (1987) and by Edge et al., Anal. Biochem.,118:131 (1981). Enzymatic cleavage of carbohydrate moieties onpolypeptides can be achieved by the use of a variety of endo- andexo-glycosidases as described by Thotakura et al., Meth. Enzymol.,138:350 (1987).

[0158] Another type of covalent modification of CA comprises linking theCA polypeptide to one of a variety of nonproteinaceous polymers, e.g.,polyethylene glycol, polypropylene glycol, or polyoxyalkylenes, in themanner set forth in U.S. Pat. Nos. 4,640,835; 4,496,689; 4,301,144;4,670,417; 4,791,192 or 4,179,337.

[0159] CA polypeptides of the present invention may also be modified ina way to form chimeric molecules comprising a CA polypeptide fused toanother, heterologous polypeptide or amino acid sequence. In oneembodiment, such a chimeric molecule comprises a fusion of a CApolypeptide with a tag polypeptide that provides an epitope to which ananti-tag antibody can selectively bind. The epitope tag is generallyplaced at the amino-or carboxyl-terminus of the CA polypeptide, althoughinternal fusions may also be tolerated in some instances. The presenceof such epitope-tagged forms of a CA polypeptide can be detected usingan antibody against the tag polypeptide. Also, provision of the epitopetag enables the CA polypeptide to be readily purified by affinitypurification using an anti-tag antibody or another type of affinitymatrix that binds to the epitope tag. In an alternative embodiment, thechimeric molecule may comprise a fusion of a CA polypeptide with animmunoglobulin or a particular region of an immunoglobulin. For abivalent form of the chimeric molecule, such a fusion could be to the Fcregion of an IgG molecule.

[0160] Various tag polypeptides and their respective antibodies are wellknown in the art. Examples include poly-histidine (poly-his) orpoly-histidine-glycine (poly-his-gly) tags; the flu HA tag polypeptideand its antibody 12CA5 [Field et al., Mol. Cell. Biol., 8:2159-2165(1988)]; the c-myc tag and the 8F9, 3C7, 6E10, G4, B7 and 9E10antibodies thereto [Evan et al., Molecular and Cellular Biology,5:3610-3616 (1985)]; and the Herpes Simplex virus glycoprotein D (gD)tag and its antibody [Paborsky et al., Protein Engineering, 3(6):547-553(1990)]. Other tag polypeptides include the Flag-peptide [Hopp et al.,BioTechnology, 6:1204-1210 (1988)]; the KT3 epitope peptide [Martin etal., Science, 255:192-194 (1992)]; tubulin epitope peptide [Skinner etal., J. Biol. Chem., 266:15163-15166 (1991)]; and the T7 gene 10 proteinpeptide tag [Lutz-Freyermuth et al., Proc. Natl. Acad. Sci. USA,87:6393-6397 (1990)].

[0161] Also included with the definition of CA protein in one embodimentare other CA proteins of the CA family, and CA proteins from otherorganisms, which are cloned and expressed as outlined below. Thus, probeor degenerate polymerase chain reaction (PCR) primer sequences may beused to find other related CA proteins from humans or other organisms.As will be appreciated by those in the art, particularly useful probeand/or PCR primer sequences include the unique areas of the CA nucleicacid sequence. As is generally known in the art, preferred PCR primersare from about 15 to about 35 nucleotides in length, with from about 20to about 30 being preferred, and may contain inosine as needed. Theconditions for the PCR reaction are well known in the art.

[0162] In addition, as is outlined herein, CA proteins can be made thatare longer than those encoded by the nucleic acids of the figures, forexample, by the elucidation of additional sequences, the addition ofepitope or purification tags, the addition of other fusion sequences,etc.

[0163] CA proteins may also be identified as being encoded by CA nucleicacids. Thus, CA proteins are encoded by nucleic acids that willhybridize to the sequences of the sequence listings, or theircomplements, as outlined herein.

[0164] CA Antigens and Antibodies Thereto

[0165] In one embodiment, the invention provides CA specific antibodies.In a preferred embodiment, when the CA protein is to be used to generateantibodies, for example for immunotherapy, the CA protein should shareat least one epitope or determinant with the full-length protein. By“epitope” or “determinant” herein is meant a portion of a protein thatwill generate and/or bind an antibody or T-cell receptor in the contextof MHC. Thus, in most instances, antibodies made to a smaller CA proteinwill be able to bind to the full-length protein. In a preferredembodiment, the epitope is unique; that is, antibodies generated to aunique epitope show little or no cross-reactivity.

[0166] Any polypeptide sequence encoded by the CA polynucleotidesequences may be analyzed to determine certain preferred regions of thepolypeptide. Regions of high antigenicity are determined from data byDNASTAR analysis by choosing values that represent regions of thepolypeptide that are likely to be exposed on the surface of thepolypeptide in an environment in which antigen recognition may occur inthe process of initiation of an immune response. For example, the aminoacid sequence of a polypeptide encoded by a CA polynucleotide sequencemay be analyzed using the default parameters of the DNASTAR computeralgorithm (DNASTAR, Inc., Madison, Wis.; http://www.dnastar.com/).

[0167] Polypeptide features that may be routinely obtained using theDNASTAR computer algorithm include, but are not limited to,Garnier-Robson alpha-regions, beta-regions, turn-regions, andcoil-regions (Gamier et al. J. Mol. Biol., 120: 97 (1978)); Chou-Fasmanalpha-regions, beta-regions, and turn-regions (Adv. in Enzymol.,47:45-148 (1978)); Kyte-Doolittle hydrophilic regions and hydrophobicregions (J. Mol. Biol., 157:105-132 (1982)); Eisenberg alpha- andbeta-amphipathic regions; Karplus-Schulz flexible regions; Eminisurface-forming regions (J. Virol., 55(3):836-839 (1985)); andJameson-Wolf regions of high antigenic index (CABIOS, 4(1):181-186(1988)). Kyte-Doolittle hydrophilic regions and hydrophobic regions,Emini surface-forming regions, and Jameson-Wolf regions of highantigenic index (i.e., containing four or more contiguous amino acidshaving an antigenic index of greater than or equal to 1.5, as identifiedusing the default parameters of the Jameson-Wolf program) can routinelybe used to determine polypeptide regions that exhibit a high degree ofpotential for antigenicity. One approach for preparing antibodies to aprotein is the selection and preparation of an amino acid sequence ofall or part of the protein, chemically synthesizing the sequence andinjecting it into an appropriate animal, typically a rabbit, hamster ora mouse. Oligopeptides can be selected as candidates for the productionof an antibody to the CA protein based upon the oligopeptides lying inhydrophilic regions, which are thus likely to be exposed in the matureprotein. Additional oligopeptides can be determined using, for example,the Antigenicity Index, Welling, G. W. et al., FEBS Lett. 188:215-218(1985), incorporated herein by reference.

[0168] In one embodiment, the term “antibody” includes antibodyfragments, as are known in the art, including Fab, Fab₂, single chainantibodies (Fv for example), chimeric antibodies, etc., either producedby the modification of whole antibodies or those synthesized de novousing recombinant DNA technologies.

[0169] Methods of preparing polyclonal antibodies are known to theskilled artisan. Polyclonal antibodies can be raised in a mammal, forexample, by one or more injections of an immunizing agent and, ifdesired, an adjuvant. Typically, the immunizing agent and/or adjuvantwill be injected in the mammal by multiple subcutaneous orintraperitoneal injections. The immunizing agent may include a proteinencoded by a nucleic acid of the figures or fragment thereof or a fusionprotein thereof. It may be useful to conjugate the immunizing agent to aprotein known to be immunogenic in the mammal being immunized. Examplesof such immunogenic proteins include but are not limited to keyholelimpet hemocyanin, serum albumin, bovine thyroglobulin, and soybeantrypsin inhibitor. Examples of adjuvants that may be employed includeFreund's complete adjuvant and MPL-TDM adjuvant (monophosphoryl Lipid A,synthetic trehalose dicorynomycolate). The immunization protocol may beselected by one skilled in the art without undue experimentation.

[0170] The antibodies may, alternatively, be monoclonal antibodies.Monoclonal antibodies may be prepared using hybridoma methods, such asthose described by Kohler and Milstein, Nature, 256:495 (1975). In ahybridoma method, a mouse, hamster, or other appropriate host animal, istypically immunized with an immunizing agent to elicit lymphocytes thatproduce or are capable of producing antibodies that will specificallybind to the immunizing agent. Alternatively, the lymphocytes may beimmunized in vitro. The immunizing agent will typically include apolypeptide encoded by a nucleic acid of Tables 1-6, or fragment thereofor a fusion protein thereof. Generally, either peripheral bloodlymphocytes (“PBLs”) are used if cells of human origin are desired, orspleen cells or lymph node cells are used if non-human mammalian sourcesare desired. The lymphocytes are then fused with an immortalized cellline using a suitable fusing agent, such as polyethylene glycol, to forma hybridoma cell (Goding, Monoclonal Antibodies: Principles andPractice, Academic Press, (1986) pp. 59-103). Immortalized cell linesare usually transformed mammalian cells, particularly myeloma cells ofrodent, bovine and human origin. Usually, rat or mouse myeloma celllines are employed. The hybridoma cells may be cultured in a suitableculture medium that preferably contains one or more substances thatinhibit the growth or survival of the unfused, immortalized cells. Forexample, if the parental cells lack the enzyme hypoxanthine guaninephosphoribosyl transferase (HGPRT or HPRT), the culture medium for thehybridomas typically will include hypoxanthine, aminopterin, andthymidine (“HAT medium”), which substances prevent the growth ofHGPRT-deficient cells.

[0171] Monoclonal antibody technology is used in implementing research,diagnosis and therapy. Monoclonal antibodies are used inradioimmunoassays, enzyme-linked immunosorbent assays,immunocytopathology, and flow cytometry for in vitro diagnosis, and invivo for diagnosis and immunotherapy of human disease. Waldmann, T. A.(1991) Science 252:1657-1662. In particular, monoclonal antibodies havebeen widely applied to the diagnosis and therapy of cancer, wherein itis desirable to target malignant lesions while avoiding normal tissue.See, e.g., U.S. Pat. No. 4,753,894 to Frankel, et al.; U.S. Pat. No.4,938,948 to Ring et al.; and U.S. Pat. No. 4,956,453 to Bjorn et al.

[0172] In one embodiment, the antibodies are bispecific antibodies.Bispecific antibodies are monoclonal, preferably human or humanized,antibodies that have binding specificities for at least two differentantigens. A number of “humanized” antibody molecules comprising anantigen-binding site derived from a non-human immunoglobulin have beendescribed, including chimeric antibodies having rodent V regions andtheir associated CDRs fused to human constant domains (Winter et al.(1991) Nature 349:293-299; Lobuglio et al. (1989) Proc. Nat. Acad. Sci.USA 86:4220-4224; Shaw et al. (1987) J Immunol. 138:4534-4538; and Brownet al. (1987) Cancer Res. 47:3577-3583), rodent CDRs grafted into ahuman supporting FR prior to fusion with an appropriate human antibodyconstant domain (Riechmann et al. (1988) Nature 332:323-327; Verhoeyenet al. (1988) Science 239:1534-1536; and Jones et al. (1986) Nature321:522-525), and rodent CDRs supported by recombinantly veneered rodentFRs (European-Patent Publication No. 519,596, published Dec. 23, 1992).These “humanized” molecules are designed to minimize unwantedimmunological response toward rodent antihuman antibody molecules whichlimits the duration and effectiveness of therapeutic applications ofthose moieties in human recipients. In the present case, one of thebinding specificities is for a protein encoded by a nucleic acid ofTables 1-6, or a fragment thereof, the other one is for any otherantigen, and preferably for a cell-surface protein or receptor orreceptor subunit, preferably one that is tumor specific.

[0173] In a preferred embodiment, the antibodies to CA are capable ofreducing or eliminating the biological function of CA, as is describedbelow. That is, the addition of anti-CA antibodies (either polyclonal orpreferably monoclonal) to CA (or cells containing CA) may reduce oreliminate the CA activity. Generally, at least a 25% decrease inactivity is preferred, with at least about 50% being particularlypreferred and about a 95-100% decrease being especially preferred.

[0174] In a preferred embodiment the antibodies to the CA proteins arehumanized antibodies. “Humanized” antibodies refer to a molecule havingan antigen binding site that is substantially derived from animmunoglobulin from a non-human species and the remaining immunoglobulinstructure of the molecule based upon the structure and/or sequence of ahuman immunoglobulin. The antigen binding site may comprise eithercomplete variable domains fused onto constant domains or only thecomplementarity determining regions (CDRs) grafted onto appropriateframework regions in the variable domains. Antigen binding sites may bewild type or modified by one or more amino acid substitutions, e.g.,modified to resemble human immunoglobulin more closely. Alternatively, ahumanized antibody may be derived from a chimeric antibody that retainsor substantially retains the antigen-binding properties of the parental,non-human, antibody but which exhibits diminished immunogenicity ascompared to the parental antibody when administered to humans. Thephrase “chimeric antibody,” as used herein, refers to an antibodycontaining sequence derived from two different antibodies (see, e.g.,U.S. Pat. No. 4,816,567) that typically originate from differentspecies. Typically, in these chimeric antibodies, the variable region ofboth light and heavy chains mimics the variable regions of antibodiesderived from one species of mammals, while the constant portions arehomologous to the sequences in antibodies derived from another. Mosttypically, chimeric antibodies comprise human and murine antibodyfragments, generally human constant and mouse variable regions.Humanized antibodies include human immunoglobulins (recipient antibody)in which residues form a complementary determining region (CDR) of therecipient are replaced by residues from a CDR of a non-human species(donor antibody) such as mouse, rat or rabbit having the desiredspecificity, affinity and capacity. In some instances, Fv frameworkresidues of the human immunoglobulin are replaced by correspondingnon-human residues. Humanized antibodies may also comprise residues thatare found neither in the recipient antibody nor in the imported CDR orframework sequences. In general, the humanized antibody will comprisesubstantially all of at least one, and typically two, variable domains,in which all or substantially all of the CDR regions correspond to thoseof a non-human immunoglobulin and all or substantially all of theframework residues (FR) regions are those of a human immunoglobulinconsensus sequence. The humanized antibody optimally also will compriseat least a portion of an immunoglobulin constant region (Fe), typicallythat of a human immunoglobulin (Jones et al., Nature, 321:522-525(1986); Riechmann et al., Nature, 332:323-329 (1988); and Presta, Curr.Op. Struct. Biol., 2:593-596 (1992)). One clear advantage to suchchimeric forms is that, for example, the variable regions canconveniently be derived from presently known sources using readilyavailable hybridomas or B cells from non human host organisms incombination with constant regions derived from, for example, human cellpreparations. While the variable region has the advantage of ease ofpreparation, and the specificity is not affected by its source, theconstant region being human, is less likely to elicit an immune responsefrom a human subject when the antibodies are injected than would theconstant region from a non-human source. However; the definition is notlimited to this particular example.

[0175] Because humanized antibodies are far less immunogenic in humansthan the parental mouse monoclonal antibodies, they can be used for thetreatment of humans with far less risk of anaphylaxis. Thus, theseantibodies may be preferred in therapeutic applications that involve invivo administration to a human such as, e.g., use as radiationsensitizers for the treatment of neoplastic disease or use in methods toreduce the side effects of, e.g., cancer therapy. Methods for humanizingnon-human antibodies are well known in the art. Generally, a humanizedantibody has one or more amino acid residues introduced into it from asource that is non-human. These non-human amino acid residues are oftenreferred to as import residues, which are typically taken from an importvariable domain. Humanization can be essentially performed following themethod of Winter and co-workers (Jones et al., Nature 321:522-525(1986); Riechmann et al., Nature 332:323-327 (1988); Verhoeyen et al.,Science 239:1534-1536 (1988)), by substituting rodent CDRs or CDRsequences for the corresponding sequences of a human antibody.Accordingly, such humanized antibodies are chimeric antibodies (U.S.Pat. No. 4,816,567), wherein substantially less than an intact humanvariable domain has been substituted by the corresponding sequence froma non-human species. In practice, humanized antibodies are typicallyhuman antibodies in which some CDR residues and possibly some FRresidues are substituted by residues from analogous sites in rodentantibodies.

[0176] Human antibodies can also be produced using various techniquesknown in the art, including phage display libraries [Hoogenboom andWinter, J. Mol. Biol., 227:381 (1991); Marks et al., J. Mol. Biol.,222:581 (1991)]. The techniques of Cole et al. and Boerner et al. arealso available for the preparation of human monoclonal antibodies [Coleet al., Monoclonal Antibodies and Cancer Therapy, Alan R. Liss, p. 77(1985) and Boerner et al., J. Immunol., 147(1):86-95 (1991)]. Humanizedantibodies may be achieved by a variety of methods including, forexample: (1) grafting the non-human complementarity determining regions(CDRs) onto a human framework and constant region (a process referred toin the art as “humanizing”), or, alternatively, (2) transplanting theentire non-human variable domains, but “cloaking” them with a human-likesurface by replacement of surface residues (a process referred to in theart as “veneering”). In the present invention, humanized antibodies willinclude both “humanized” and “veneered” antibodies. Similarly, humanantibodies can be made by introducing human immunoglobulin loci intotransgenic animals, e.g., mice in which the endogenous immunoglobulingenes have been partially or completely inactivated. Upon challenge,human antibody production is observed, which closely resembles that seenin humans in all respects, including gene rearrangement, assembly, andantibody repertoire. This approach is described, for example, in U.S.Pat. Nos. 5,545,807; 5,545,806; 5,569,825; 5,625,126; 5,633,425;5,661,016, and in the following scientific publications: Marks et al.,Bio/Technology 10, 779-783 (1992); Lonberg et al., Nature 368 856-859(1994); Morrison, Nature 368, 812-13 (1994); Fishwild et al., NatureBiotechnology 14, 845-51 (1996); Neuberger, Nature Biotechnology 14, 826(1996); Lonberg and Huszar, Intern. Rev. Immunol. 13 65-93 (1995); Joneset al., Nature 321:522-525 (1986); Morrison et al., Proc. Natl. Acad.Sci, US.A., 81:6851-6855 (1984); Morrison and Oi, Adv. Immunol.,44:65-92 (1988); Verhoeyer et al., Science 239:1534-1536 (1988); Padlan,Molec. Immun. 28:489-498 (1991); Padlan, Molec. Immunol. 31(3):169-217(1994); and Kettleborough, C. A. et al., Protein Eng. 4(7):773-83 (1991)each of which is incorporated herein by reference.

[0177] The phrase “complementarity determining region” refers to aminoacid sequences which together define the binding affinity andspecificity of the natural Fv region of a native immunoglobulin bindingsite. See, e.g., Chothia et al., J. Mol. Biol. 196:901-917 (1987); Kabatet al., U.S. Dept, of Health and Human Services NIH Publication No.91-3242 (1991). The phrase “constant region” refers to the portion ofthe antibody molecule that confers effector functions. In the presentinvention, mouse constant regions are substituted by human constantregions. The constant regions of the subject humanized antibodies arederived from human immunoglobulins. The heavy chain constant region canbe selected from any of the five isotypes: alpha, delta, epsilon, gammaor mu. One method of humanizing antibodies comprises aligning thenon-human heavy and light chain sequences to human heavy and light chainsequences, selecting and replacing the non-human framework with a humanframework based on such alignment, molecular modeling to predict theconformation of the humanized sequence and comparing to the conformationof the parent antibody. This process is followed by repeated backmutation of residues in the CDR region that disturb the structure of theCDRs until the predicted conformation of the humanized sequence modelclosely approximates the conformation of the non-human CDRs of theparent non-human antibody. Such humanized antibodies may be furtherderivatized to facilitate uptake and clearance, e.g, via Ashwellreceptors. See, e.g., U.S. Pat. Nos. 5,530,101 and 5,585,089 which areincorporated herein by reference.

[0178] Humanized antibodies to CA polypeptides can also be producedusing transgenic animals that are engineered to contain humanimmunoglobulin loci. For example, WO 98/24893 disclosestransgenic-animals having a human Ig locus wherein the animals do notproduce functional endogenous immunoglobulins due to the inactivation ofendogenous heavy and light chain loci. WO 91/10741 also disclosestransgenic non-primate mammalian hosts capable of mounting an immuneresponse to an immunogen, wherein the antibodies have primate constantand/or variable regions, and wherein the endogenousimmunoglobulin-encoding loci are substituted or inactivated. WO 96/30498discloses the use of the Cre/Lox system to modify the immunoglobulinlocus in a mammal, such as to replace all or a portion of the constantor variable region to form a modified antibody molecule. WO 94/02602discloses non-human mammalian hosts having inactivated endogenous Igloci and functional human Ig loci. U.S. Pat. No. 5,939,598 disclosesmethods of making transgenic mice in which the mice lack endogenousheavy chains, and express an exogenous immunoglobulin locus comprisingone or more xenogeneic constant regions.

[0179] Using a transgenic animal described above, an immune response canbe produced to a selected antigenic molecule, and antibody-producingcells can be removed from the animal and used to produce hybridomas thatsecrete human monoclonal antibodies. Immunization protocols, adjuvants,and the like are known in the art, and are used in immunization of, forexample, a transgenic mouse as described in WO 96/33735. The monoclonalantibodies can be tested for the ability to inhibit or neutralize thebiological activity or physiological effect of the correspondingprotein.

[0180] In the present invention, CA polypeptides of the invention andvariants thereof are used to immunize a transgenic animal as describedabove. Monoclonal antibodies are made using methods known in the art,and the specificity of the antibodies is tested using isolated CApolypeptides. Methods for preparation of the human or primate CA or anepitope thereof include, but are not limited to chemical synthesis,recombinant DNA techniques or isolation from biological samples.Chemical synthesis of a peptide can be performed, for example, by theclassical Merrifeld method of solid phase peptide synthesis (Merrifeld,J. Am. Chem. Soc. 85:2149, 1963 which is incorporated by reference) orthe FMOC strategy on a Rapid Automated Multiple Peptide Synthesis system(E. I. du Pont de Nemours Company, Wilmington, Del.) (Caprino and Han,J. Org. Chem. 37:3404, 1972 which is incorporated by reference).

[0181] Polyclonal antibodies can be prepared by immunizing rabbits orother animals by injecting antigen followed by subsequent boosts atappropriate intervals. The animals are bled and sera assayed againstpurified CA proteins usually by ELISA or by bioassay based upon theability to block the action of CA proteins. When using avian species,e.g., chicken, turkey and the like, the antibody can be isolated fromthe yolk of the egg. Monoclonal antibodies can be prepared after themethod of Milstein and Kohler by fusing splenocytes from immunized micewith continuously replicating tumor cells such as myeloma or lymphomacells. (Milstein and Kohler, Nature, 256:495-497, 1975; Gulfre andMilstein, Methods in Enzymology: Immunochemical Techniques 73:1-46,Langone and Banatis eds., Academic Press, 1981 which are incorporated byreference). The hybridoma cells so formed are then cloned by limitingdilution methods and supernates assayed for antibody production byELISA, RIA or bioassay.

[0182] The unique ability of antibodies to recognize and specificallybind to target proteins provides an approach for treating anoverexpression of the protein. Thus, another aspect of the presentinvention provides for a method for preventing or treating diseasesinvolving overexpression of a CA polypeptide by treatment of a patientwith specific antibodies to the CA protein.

[0183] Specific antibodies, either polyclonal or monoclonal, to the CAproteins can be produced by any suitable method known in the art asdiscussed above. For example, murine or human monoclonal antibodies canbe produced by hybridoma technology or, alternatively, the CA proteins,or an immunologically active fragment thereof, or an anti-idiotypicantibody, or fragment thereof can be administered to an animal to elicitthe production of antibodies capable of recognizing and binding to theCA proteins. Such antibodies can be from any class of antibodiesincluding, but not limited to IgG, IgA, IgM, IgD, and IgE or in the caseof avian species, IgY and from any subclass of antibodies.

[0184] By immunotherapy is meant treatment of a cancer with an antibodyraised against a CA protein. As used herein, immunotherapy can bepassive or active. Passive immunotherapy as defined herein is thepassive transfer of antibody to a recipient (patient). Activeimmunization is the induction of antibody and/or T-cell responses in arecipient (patient). Induction of an immune response is the result ofproviding the recipient with an antigen to which antibodies are raised.As appreciated by one of ordinary skill in the art, the antigen may beprovided by injecting a polypeptide against which antibodies are desiredto be raised into a recipient, or contacting the recipient with anucleic acid capable of expressing the antigen and under conditions forexpression of the antigen.

[0185] In a preferred embodiment, oncogenes which encode secreted growthfactors may be inhibited by raising antibodies against CA proteins thatare secreted proteins as described above. Without being bound by theory,antibodies used for treatment, bind and prevent the secreted proteinfrom binding to its receptor, thereby inactivating the secreted CAprotein.

[0186] In another preferred embodiment, the CA protein to whichantibodies are raised is a transmembrane protein. Without being bound bytheory, antibodies used for treatment, bind the extracellular domain ofthe CA protein and prevent it from binding to other proteins, such ascirculating ligands or cell-associated molecules. The antibody may causedown-regulation of the transmembrane CA protein. As will be appreciatedby one of ordinary skill in the art, the antibody may be a competitive,non-competitive or uncompetitive inhibitor of protein binding to theextracellular domain of the CA protein. The antibody is also anantagonist of the CA protein. Further, the antibody prevents activationof the transmembrane CA protein. In one aspect, when the antibodyprevents the binding of other molecules to the CA protein, the antibodyprevents growth of the cell. The antibody may also sensitize the cell tocytotoxic agents, including, but not limited to TNF-α, TNF-β, IL-1,INF-γ and IL-2, or chemotherapeutic agents including 5FU, vinblastine,actinomycin D, cisplatin, methotrexate, and the like. In some instancesthe antibody belongs to a sub-type that activates serum complement whencomplexed with the transmembrane protein thereby mediating cytotoxicity.Thus, cancers may be treated by administering to a patient antibodiesdirected against the transmembrane CA protein.

[0187] In another preferred embodiment, the antibody is conjugated to atherapeutic moiety. In one aspect the therapeutic moiety is a smallmolecule that modulates the activity of the CA protein. In anotheraspect the therapeutic moiety modulates the activity of moleculesassociated with or in close proximity to the CA protein. The therapeuticmoiety may inhibit enzymatic activity such as protease or protein kinaseactivity associated with cancer.

[0188] In a preferred embodiment, the therapeutic moiety may also be acytotoxic agent. In this method, radioisotopes, natural toxins,chemotherapy agents, or other substances (such as biological responsemodifiers) are chemically linked or conjugated to a monoclonal antibodyto form “immunoconjugates” and “immunotoxins” which target the cytotoxicagent to tumor tissue or cells resulting in a reduction in the number ofafflicted cells, thereby reducing symptoms associated with cancers,including lymphoma. Cytotoxic agents are numerous and varied andinclude, but are not limited to, cytotoxic drugs or toxins or activefragments of such toxins. Suitable toxins and their correspondingfragments include diphtheria A chain, exotoxin A chain, ricin A chain,abrin A chain, curcin, crotin, phenomycin, enomycin and the like.Cytotoxic agents also include radiochemicals made by conjugatingradioisotopes to antibodies raised against CA proteins, or binding of aradionuclide to a chelating agent that has been covalently attached tothe antibody. Targeting the therapeutic moiety to transmembrane CAproteins not only serves to increase the local concentration oftherapeutic moiety in the cancer of interest, i.e., lymphoma, but alsoserves to reduce deleterious side effects that may be associated withthe therapeutic moiety. A number of investigators have used monoclonalantibodies as carriers of cytotoxic substances in attempts toselectively direct those agents to malignant tissue. More particularly,a number of monoclonal antibodies have been conjugated to toxins such asricin, abrin, diphtheria toxin and Pseudomonas exotoxin or toenzymatically active portions (A chains) thereof via heterobifunctionalagents. See, e.g., U.S. Pat. No. 4,753,894 to Frankel et al.; Nevelle,et al. (1982) Immunol Rev 62:75-91; Ross et al. (1980) Eur. J Biochem104; Vitteta et al. (1982) Immunol Rev 62:158-183; Raso et al. (1982)Cancer Res 42:457-464, and Trowbridge et al. (1981) Nature 294:171-173.

[0189] In another preferred embodiment, the CA protein against which theantibodies are raised is an intracellular protein. In this case, theantibody may be conjugated to a protein that facilitates entry into thecell. In one case, the antibody enters the cell by endocytosis. Inanother embodiment, a nucleic acid encoding the antibody is administeredto the individual or cell. Moreover, wherein the CA protein can betargeted within a cell, e.g., the nucleus, an antibody thereto containsa signal for that target localization, e.g., a nuclear localizationsignal.

[0190] The CA antibodies of the invention specifically bind to CAproteins. By “specifically bind” herein is meant that the antibodiesbind to the protein with a binding constant in the range of 10⁻⁴-10⁻⁶M⁻¹, with a preferred range being 10⁻⁷-10⁻⁹ M⁻¹.

[0191] In a preferred embodiment, the CA protein is purified or isolatedafter expression. CA proteins may be isolated or purified in a varietyof ways known to those skilled in the art depending on what othercomponents are present in the sample. Standard purification methodsinclude electrophoretic, molecular, immunological and chromatographictechniques, including ion exchange, hydrophobic, affinity, andreverse-phase HPLC chromatography, and chromatofocusing. For example,the CA protein may be purified using a standard anti-CA antibody column.Ultrafiltration and diafiltration techniques, in conjunction withprotein concentration, are also useful. For general guidance in suitablepurification techniques, see Scopes, R., Protein Purification,Springer-Verlag, NY (1982). The degree of purification necessary willvary depending on the use of the CA protein. In some instances nopurification will be necessary.

[0192] Detection of Cancer Phenotype

[0193] Once expressed and purified if necessary, the CA proteins andnucleic acids are useful in a number of applications. In one aspect, theexpression levels of genes are determined for different cellular statesin the cancer phenotype; that is, the expression levels of genes innormal tissue and in cancer tissue (and in some cases, for varyingseverities of lymphoma that relate to prognosis, as outlined below) areevaluated to provide expression profiles. An expression profile of aparticular cell state or point of development is essentially a“fingerprint” of the state; while two states may have any particulargene similarly expressed, the evaluation of a number of genessimultaneously allows the generation of a gene expression profile thatis unique to the state of the cell. By comparing expression profiles ofcells in different states, information regarding which genes areimportant (including both up- and down-regulation of genes) in each ofthese states is obtained. Then, diagnosis may be done or confirmed: doestissue from a particular patient have the gene expression profile ofnormal or cancer tissue.

[0194] “Differential expression,” or equivalents used herein, refers toboth qualitative as well as quantitative differences in the temporaland/or cellular expression patterns of genes, within and among thecells. Thus, a differentially expressed gene can qualitatively have itsexpression altered, including an activation or inactivation, in, forexample, normal versus cancer tissue. That is, genes may be turned on orturned off in a particular state, relative to another state. As isapparent to the skilled artisan, any comparison of two or more statescan be made. Such a qualitatively regulated gene will exhibit anexpression pattern within a state or cell type which is detectable bystandard techniques in one such state or cell type, but is notdetectable in both. Alternatively, the determination is quantitative inthat expression is increased or decreased; that is, the expression ofthe gene is either up-regulated, resulting in an increased amount oftranscript, or down-regulated, resulting in a decreased amount oftranscript. The degree to which expression differs need only be largeenough to quantify via standard characterization techniques as outlinedbelow, such as by use of Affymetrix GeneChip® expression arrays,Lockhart, Nature Biotechnology, 14:1675-1680 (1996), hereby expresslyincorporated by reference. Other techniques include, but are not limitedto, quantitative reverse transcriptase PCR, Northern analysis and RNaseprotection. As outlined above, preferably the change in expression (i.e.upregulation or downregulation) is at least about 50%, more preferablyat least about 100%, more preferably at least about 150%, morepreferably, at least about 200%, with from 300 to at least 1000% beingespecially preferred.

[0195] As will be appreciated by those in the art, this may be done byevaluation at either the gene transcript, or the protein level; that is,the amount of gene expression may be monitored using nucleic acid probesto the DNA or RNA equivalent of the gene transcript, and thequantification of gene expression levels, or, alternatively, the finalgene product itself (protein) can be monitored, for example through theuse of antibodies to the CA protein and standard immunoassays (ELISAs,etc.) or other techniques, including mass spectroscopy assays, 2D gelelectrophoresis assays, etc. Thus, the proteins corresponding to CAgenes, i.e. those identified as being important in a particular cancerphenotype, i.e., lymphoma, can be evaluated in a diagnostic testspecific for that cancer.

[0196] In a preferred embodiment, gene expression monitoring is done anda number of genes, i.e. an expression profile, is monitoredsimultaneously, although multiple protein expression monitoring can bedone as well. Similarly, these assays may be done on an individual basisas well.

[0197] In this embodiment, the CA nucleic acid probes may be attached tobiochips as outlined herein for the detection and quantification of CAsequences in a particular cell. The assays are done as is known in theart. As will be appreciated by those in the art, any number of differentCA sequences may be used as probes, with single sequence assays beingused in some cases, and a plurality of the sequences described hereinbeing used in other embodiments. In addition, while solid-phase assaysare described, any number of solution based assays may be done as well.

[0198] In a preferred embodiment, both solid and solution based assaysmay be used to detect CA sequences that are up-regulated ordown-regulated in cancers as compared to normal tissue. In instanceswhere the CA sequence has been altered but shows the same expressionprofile or an altered expression profile, the protein will be detectedas outlined herein.

[0199] In a preferred embodiment nucleic acids encoding the CA proteinare detected. Although DNA or RNA encoding the CA protein may bedetected, of particular interest are methods wherein the mRNA encoding aCA protein is detected. The presence of mRNA in a sample is anindication that the CA gene has been transcribed to form the mRNA, andsuggests that the protein is expressed. Probes to detect the mRNA can beany nucleotide/deoxynucleotide probe that is complementary to and basepairs with the mRNA and includes but is not limited to oligonucleotides,cDNA or RNA. Probes also should contain a detectable label, as definedherein. In one method the mRNA is detected after immobilizing thenucleic acid to be examined on a solid support such as nylon membranesand hybridizing the probe with the sample. Following washing to removethe non-specifically bound probe, the label is detected. In anothermethod detection of the mRNA is performed in situ. In this methodpermeabilized cells or tissue samples are contacted with a detectablylabeled nucleic acid probe for sufficient time to allow the probe tohybridize with the target mRNA. Following washing to remove thenon-specifically bound probe, the label is detected. For example adigoxygenin labeled riboprobe (RNA probe) that is complementary to themRNA encoding a CA protein is detected by binding the digoxygenin withan anti-digoxygenin secondary antibody and developed with nitro bluetetrazolium and 5-bromo-4-chloro-3-indoyl phosphate.

[0200] In a preferred embodiment, any of the three classes of proteinsas described herein (secreted, transmembrane or intracellular proteins)are used in diagnostic assays. The CA proteins, antibodies, nucleicacids, modified proteins and cells containing CA sequences are used indiagnostic assays. This can be done on an individual gene orcorresponding polypeptide level, or as sets of assays.

[0201] As described and defined herein, CA proteins find use as markersof cancers, including lymphomas such as, but not limited to, Hodgkin'sand non-Hodgkin's lymphoma. Detection of these proteins in putativecancer tissue or patients allows for a determination or diagnosis of thetype of cancer. Numerous methods known to those of ordinary skill in theart find use in detecting cancers. In one embodiment, antibodies areused to detect CA proteins. A preferred method separates proteins from asample or patient by electrophoresis on a gel (typically a denaturingand reducing protein gel, but may be any other type of gel includingisoelectric focusing gels and the like). Following separation ofproteins, the CA protein is detected by immunoblotting with antibodiesraised against the CA protein. Methods of immunoblotting are well knownto those of ordinary skill in the art.

[0202] In another preferred method, antibodies to the CA protein finduse in in situ imaging techniques. In this method cells are contactedwith from one to many antibodies to the CA protein(s). Following washingto remove non-specific antibody binding, the presence of the antibody orantibodies is detected. In one embodiment the antibody is detected byincubating with a secondary antibody that contains a detectable label.In another method the primary antibody to the CA protein(s) contains adetectable label. In another preferred embodiment each one of multipleprimary antibodies contains a distinct and detectable label. This methodfinds particular use in simultaneous screening for a plurality of CAproteins. As will be appreciated by one of ordinary skill in the art,numerous other histological imaging techniques are useful in theinvention.

[0203] In a preferred embodiment the label is detected in a fluorometerthat has the ability to detect and distinguish emissions of differentwavelengths. In addition, a fluorescence activated cell sorter (FACS)can be used in the method.

[0204] In another preferred embodiment, antibodies find use indiagnosing cancers from blood samples. As previously described, certainCA proteins are secreted/circulating molecules. Blood samples,therefore, are useful as samples to be probed or tested for the presenceof secreted CA proteins. Antibodies can be used to detect the CAproteins by any of the previously described immunoassay techniquesincluding ELISA, immunoblotting (Western blotting), immunoprecipitation,BIACORE technology and the like, as will be appreciated by one ofordinary skill in the art.

[0205] In a preferred embodiment, in situ hybridization of labeled CAnucleic acid probes to tissue arrays is done. For example, arrays oftissue samples, including CA tissue and/or normal tissue, are made. Insitu hybridization as is known in the art can then be done.

[0206] It is understood that when comparing the expression fingerprintsbetween an individual and a standard, the skilled artisan can make adiagnosis as well as a prognosis. It is further understood that thegenes that indicate diagnosis may differ from those that indicateprognosis.

[0207] In a preferred embodiment, the CA proteins, antibodies, nucleicacids, modified proteins and cells containing CA sequences are used inprognosis assays. As above, gene expression profiles can be generatedthat correlate to cancer, especially lymphoma, severity, in terms oflong term prognosis. Again, this may be done on either a protein or genelevel, with the use of genes being preferred. As above, the CA probesare attached to biochips for the detection and quantification of CAsequences in a tissue or patient. The assays proceed as outlined fordiagnosis.

[0208] Screening for CA-Targeted Drugs

[0209] In one embodiment, any of the CA sequences as described hereinare used in drug screening assays. The CA proteins, antibodies, nucleicacids, modified proteins and cells containing CA sequences are used indrug screening assays or by evaluating the effect of drug candidates ona “gene expression profile” or expression profile of polypeptides. Inone embodiment, the expression profiles are used, preferably inconjunction with high throughput screening techniques to allowmonitoring for expression profile genes after treatment with a candidateagent, Zlokarnik, et al., Science 279, 84-8 (1998), Heid, et al., GenomeRes., 6:986-994 (1996).

[0210] In another embodiment, the CA proteins, antibodies, nucleicacids, modified proteins and cells containing the native or modified CAproteins are used in screening assays. That is, the present inventionprovides novel methods for screening for compositions that modulate thecancer phenotype. As above, this can be done by screening for modulatorsof gene expression or for modulators of protein activity. Similarly,this may be done on an individual gene or protein level or by evaluatingthe effect of drug candidates on a “gene expression profile”. In apreferred embodiment, the expression profiles are used, preferably inconjunction with high throughput screening techniques to allowmonitoring for expression profile genes after treatment with a candidateagent, see Zlokarnik, supra.

[0211] Having identified the CA genes herein, a variety of assays toevaluate the effects of agents on gene expression may be executed. In apreferred embodiment, assays may be run on an individual gene or proteinlevel. That is, having identified a particular gene as aberrantlyregulated in cancer, candidate bioactive agents may be screened tomodulate the gene's regulation. “Modulation” thus includes both anincrease and a decrease in gene expression or activity. The preferredamount of modulation will depend on the original change of the geneexpression in normal versus tumor tissue, with changes of at least 10%,preferably 50%, more preferably 100-300%, and in some embodiments300-1000% or greater. Thus, if a gene exhibits a 4 fold increase intumor compared to normal tissue, a decrease of about four fold isdesired; a 10 fold decrease in tumor compared to normal tissue gives a10 fold increase in expression for a candidate agent is desired, etc.Alternatively, where the CA sequence has been altered but shows the sameexpression profile or an altered expression profile, the protein will bedetected as outlined herein.

[0212] As will be appreciated by those in the art, this may be done byevaluation at either the gene or the protein level; that is, the amountof gene expression may be monitored using nucleic acid probes and thequantification of gene expression levels, or, alternatively, the levelof the gene product itself can be monitored, for example through the useof antibodies to the CA protein and standard immunoassays.Alternatively, binding and bioactivity assays with the protein may bedone as outlined below.

[0213] In a preferred embodiment, gene expression monitoring is done anda number of genes, i.e. an expression profile, is monitoredsimultaneously, although multiple protein expression monitoring can bedone as well.

[0214] In this embodiment, the CA nucleic acid probes are attached tobiochips as outlined herein for the detection and quantification of CAsequences in a particular cell. The assays are further described below.

[0215] Generally, in a preferred embodiment, a candidate bioactive agentis added to the cells prior to analysis. Moreover, screens are providedto identify a candidate bioactive agent that modulates a particular typeof cancer, modulates CA proteins, binds to a CA protein, or interferesbetween the binding of a CA protein and an antibody.

[0216] The term “candidate bioactive agent” or “drug candidate” orgrammatical equivalents as used herein describes any molecule, e.g.,protein, oligopeptide, small organic or inorganic molecule,polysaccharide, polynucleotide, etc., to be tested for bioactive agentsthat are capable of directly or indirectly altering either the cancerphenotype, binding to and/or modulating the bioactivity of a CA protein,or the expression of a CA sequence, including both nucleic acidsequences and protein sequences. In a particularly preferred embodiment,the candidate agent suppresses a CA phenotype, for example to a normaltissue fingerprint. Similarly, the candidate agent preferably suppressesa severe CA phenotype. Generally a plurality of assay mixtures are runin parallel with different agent concentrations to obtain a differentialresponse to the various concentrations. Typically, one of theseconcentrations serves as a negative control, i.e., at zero concentrationor below the level of detection.

[0217] In one aspect, a candidate agent will neutralize the effect of aCA protein. By “neutralize” is meant that activity of a protein iseither inhibited or counter acted against so as to have substantially noeffect on a cell.

[0218] Candidate agents encompass numerous chemical classes, thoughtypically they are organic or inorganic molecules, preferably smallorganic compounds having a molecular weight of more than 100 and lessthan about 2,500 Daltons. Preferred small molecules are less than 2000,or less than 1500 or less than 11000 or less than 500 D. Candidateagents comprise functional groups necessary for structural interactionwith proteins, particularly hydrogen bonding, and typically include atleast an amine, carbonyl, hydroxyl or carboxyl group, preferably atleast two of the functional chemical groups. The candidate agents oftencomprise cyclical carbon or heterocyclic structures and/or aromatic orpolyaromatic structures substituted with one or more of the abovefunctional groups. Candidate agents are also found among biomoleculesincluding peptides, saccharides, fatty acids, steroids, purines,pyrimidines, derivatives, structural analogs or combinations thereof.Particularly preferred are peptides.

[0219] Candidate agents are obtained from a wide variety of sourcesincluding libraries of synthetic or natural compounds. For example,numerous means are available for random and directed synthesis of a widevariety of organic compounds and biomolecules, including expression ofrandomized oligonucleotides. Alternatively, libraries of naturalcompounds in the form of bacterial, fungal, plant and animal extractsare available or readily produced. Additionally, natural orsynthetically produced libraries and compounds are readily modifiedthrough conventional chemical, physical and biochemical means. Knownpharmacological agents may be subjected to directed or random chemicalmodifications, such as acylation, alkylation, esterification, oramidification to produce structural analogs.

[0220] In one embodiment, the candidate bioactive agents are proteins.By “protein” herein is meant at least two covalently attached aminoacids, which includes proteins, polypeptides, oligopeptides andpeptides. The protein may be made up of naturally occurring amino acidsand peptide bonds, or synthetic peptidomimetic structures. Thus “aminoacid”, or “peptide residue”, as used herein means both naturallyoccurring and synthetic amino acids. For example, homo-phenylalanine,citrulline and norleucine are considered amino acids for the purposes ofthe invention. “Amino acid” also includes imino acid residues such asproline and hydroxyproline. The side chains may be in either the (R) orthe (S) configuration. In the preferred embodiment, the amino acids arein the (S) or L-configuration. If non-naturally occurring side chainsare used, non-amino acid substituents may be used, for example toprevent or retard in vivo degradations.

[0221] In a preferred embodiment, the candidate bioactive agents arenaturally occurring proteins or fragments of naturally occurringproteins. Thus, for example, cellular extracts containing proteins, orrandom or directed digests of proteinaceous cellular extracts, may beused. In this way libraries of prokaryotic and eukaryotic proteins maybe made for screening in the methods of the invention. Particularlypreferred in this embodiment are libraries of bacterial, fungal, viral,and mammalian proteins, with the latter being preferred, and humanproteins being especially preferred.

[0222] In another preferred embodiment, the candidate bioactive agentsare peptides of from about 5 to about 30 amino acids, with from about 5to about 20 amino acids being preferred, and from about 7 to about 15being particularly preferred. The peptides may be digests of naturallyoccurring proteins as is outlined above, random peptides, or “biased”random peptides. By “randomized” or grammatical equivalents herein ismeant that each nucleic acid and peptide consists of essentially randomnucleotides and amino acids, respectively. Since generally these randompeptides (or nucleic acids, discussed below) are chemically synthesized,they may incorporate any nucleotide or amino acid at any position. Thesynthetic process can be designed to generate randomized proteins ornucleic acids, to allow the formation of all or most of the possiblecombinations over the length of the sequence, thus forming a library ofrandomized candidate bioactive proteinaceous agents.

[0223] In one embodiment, the library is fully randomized, with nosequence preferences or constants at any position. In a preferredembodiment, the library is biased. That is, some positions within thesequence are either held constant, or are selected from a limited numberof possibilities. For example, in a preferred embodiment, thenucleotides or amino acid residues are randomized within a definedclass, for example, of hydrophobic amino acids, hydrophilic residues,sterically biased (either small or large) residues, towards the creationof nucleic acid binding domains, the creation of cysteines, forcross-linking, prolines for SH-3 domains, serines, threonines, tyrosinesor histidines for phosphorylation sites, etc., or to purines, etc.

[0224] In one embodiment, the candidate bioactive agents are nucleicacids. As described generally for proteins, nucleic acid candidatebioactive agents may be naturally occurring nucleic acids, randomnucleic acids, or “biased” random nucleic acids. In another embodiment,the candidate bioactive agents are organic chemical moieties, a widevariety of which are available in the literature.

[0225] In assays for testing alteration of the expression profile of oneor more CA genes, after the candidate agent has been added and the cellsallowed to incubate for some period of time, a nucleic acid samplecontaining the target sequences to be analyzed is prepared. The targetsequence is prepared using known techniques (e.g., converted from RNA tolabeled cDNA, as described above) and added to a suitable microarray.For example, an in vitro reverse transcription with labels covalentlyattached to the nucleosides is performed. Generally, the nucleic acidsare labeled with a label as defined herein, especially with biotin-FITCor PE, Cy3 and Cy5.

[0226] As will be appreciated by those in the art, these assays can bedirect hybridization assays or can comprise “sandwich assays”, whichinclude the use of multiple probes, as is generally outlined in U.S.Pat. Nos. 5,681,702, 5,597,909, 5,545,730, 5,594,117, 5,591,584,5,571,670, 5,580,731, 5,571,670, 5,591,584, 5,624,802, 5,635,352,5,594,118, 5,359,100, 5,124,246 and 5,681,697, all of which are herebyincorporated by reference. In this embodiment, in general, the targetnucleic acid is prepared as outlined above, and then added to thebiochip comprising a plurality of nucleic acid probes, under conditionsthat allow the formation of a hybridization complex.

[0227] A variety of hybridization conditions may be used in the presentinvention, including high, moderate and low stringency conditions asoutlined above. The assays are generally run under stringency conditionsthat allow formation of the label probe hybridization complex only inthe presence of target. Stringency can be controlled by altering a stepparameter that is a thermodynamic variable, including, but not limitedto, temperature, formamide concentration, salt concentration, chaotropicsalt concentrations pH, organic solvent concentration, etc. Theseparameters may also be used to control non-specific binding, as isgenerally outlined in U.S. Pat. No. 5,681,697. Thus it may be desirableto perform certain steps at higher stringency conditions to reducenon-specific binding.

[0228] The reactions outlined herein may be accomplished in a variety ofways, as will be appreciated by those in the art. Components of thereaction may be added simultaneously, or sequentially, in any order,with preferred embodiments outlined below. In addition, the reaction mayinclude a variety of other reagents in the assays. These includereagents like salts, buffers, neutral proteins, e.g. albumin,detergents, etc which may be used to facilitate optimal hybridizationand detection, and/or reduce non-specific or background interactions.Also reagents that otherwise improve the efficiency of the assay, suchas protease inhibitors, nuclease inhibitors, anti-microbial agents,etc., may be used, depending on the sample preparation methods andpurity of the target. In addition, either solid phase or solution based(i.e., kinetic PCR) assays may be used.

[0229] Once the assay is run, the data are analyzed to determine theexpression levels, and changes in expression levels as between states,of individual genes, forming a gene expression profile.

[0230] In a preferred embodiment, as for the diagnosis and prognosisapplications, having identified the differentially expressed gene(s) ormutated gene(s) important in any one state, screens can be run to testfor alteration of the expression of the CA genes individually. That is,screening for modulation of regulation of expression of a single genecan be done. Thus, for example, in the case of target genes whosepresence or absence is unique between two states, screening is done formodulators of the target gene expression.

[0231] In addition, screens can be done for novel genes that are inducedin response to a candidate agent. After identifying a candidate agentbased upon its ability to suppress a CA expression pattern leading to anormal expression pattern, or modulate a single CA gene expressionprofile so as to mimic the expression of the gene from normal tissue, ascreen as described above can be performed to identify genes that arespecifically modulated in response to the agent. Comparing expressionprofiles between normal tissue and agent treated CA tissue reveals genesthat are not expressed in normal tissue or CA tissue, but are expressedin agent treated tissue. These agent specific sequences can beidentified and used by any of the methods described herein for CA genesor proteins. In particular these sequences and the proteins they encodefind use in marking or identifying agent-treated cells. In addition,antibodies can be raised against the agent-induced proteins and used totarget novel therapeutics to the treated CA tissue sample.

[0232] Thus, in one embodiment, a candidate agent is administered to apopulation of CA cells, that thus has an associated CA expressionprofile. By “administration” or “contacting” herein is meant that thecandidate agent is added to the cells in such a manner as to allow theagent to act upon the cell, whether by uptake and intracellular action,or by action at the cell surface. In some embodiments, nucleic acidencoding a proteinaceous candidate agent (i.e. a peptide) may be putinto a viral construct such as a retroviral construct and added to thecell, such that expression of the peptide agent is accomplished; see PCTUS97/01019, hereby expressly incorporated by reference.

[0233] Once the candidate agent has been administered to the cells, thecells can be washed if desired and are allowed to incubate underpreferably physiological conditions for some period of time. The cellsare then harvested and a new gene expression profile is generated, asoutlined herein.

[0234] Thus, for example, CA tissue may be screened for agents thatreduce or suppress the CA phenotype. A change in at least one gene ofthe expression profile indicates that the agent has an effect on CAactivity. By defining such a signature for the CA phenotype, screens fornew drugs that alter the phenotype can be devised. With this approach,the drug target need not be known and need not be represented in theoriginal expression screening platform, nor does the level of transcriptfor the target protein need to change.

[0235] In a preferred embodiment, as outlined above, screens may be doneon individual genes and gene products (proteins). That is, havingidentified a particular differentially expressed gene as important in aparticular state, screening of modulators of either the expression ofthe gene or the gene product itself can be done. The gene products ofdifferentially expressed genes are sometimes referred to herein as “CAproteins” or “CAP”. The CAP may be a fragment, or alternatively, be thefull-length protein to the fragment encoded by the nucleic acids ofTables 1-6. In a preferred embodiment, the CAP is selected from thehuman protein sequences shown in Tables 1-6 embodiment, the sequencesare sequence variants as further described herein.

[0236] Preferably, the CAP is a fragment approximately 14 to 24 aminoacids in length. More preferably the fragment is a soluble fragment.Preferably, the fragment includes a non-transmembrane region. In apreferred embodiment, the fragment has an N-terminal Cys to aid insolubility. In one embodiment, the C-terminus of the fragment is kept asa free acid and the N-terminus is a free amine to aid in coupling, e.g.,to a cysteine.

[0237] In one embodiment the CA proteins are conjugated to animmunogenic agent as discussed herein. In one embodiment the CA proteinis conjugated to BSA.

[0238] In a preferred embodiment, screening is done to alter thebiological function of the expression product of the CA gene. Again,having identified the importance of a gene, in a particular state,screening for agents that bind and/or modulate the biological activityof the gene product can be run as is more fully outlined below.

[0239] In a preferred embodiment, screens are designed to first findcandidate agents that can bind to CA proteins, and then these agents maybe used in assays that evaluate the ability of the candidate agent tomodulate the CAP activity and the cancer phenotype. Thus, as will beappreciated by those in the art, there are a number of different assaysthat may be run; binding assays and activity assays.

[0240] In a preferred embodiment, binding assays are done. In general,purified or isolated gene product is used; that is, the gene products ofone or more CA nucleic acids are made. In general, this is done as isknown in the art. For example, antibodies are generated to the proteingene products, and standard immunoassays are run to determine the amountof protein present. Alternatively, cells comprising the CA proteins canbe used in the assays.

[0241] Thus, in a preferred embodiment, the methods comprise combining aCA protein and a candidate bioactive agent, and determining the bindingof the candidate agent to the CA protein. Preferred embodiments utilizethe human or mouse CA protein, although other mammalian proteins mayalso be used, for example for the development of animal models of humandisease. In some embodiments, as outlined herein, variant or derivativeCA proteins may be used.

[0242] Generally, in a preferred embodiment of the methods herein, theCA protein or the candidate agent is non-diffusably bound to aninsoluble support having isolated sample receiving areas (e.g. amicrotiter plate, an array, etc.). The insoluble support may be made ofany composition to which the compositions can be bound, is readilyseparated from soluble material, and is otherwise compatible with theoverall method of screening. The surface of such supports may be solidor porous and of any convenient shape. Examples of suitable insolublesupports include microtiter plates, arrays, membranes and beads. Theseare typically made of glass, plastic (e.g., polystyrene),polysaccharides, nylon or nitrocellulose, Teflon®, etc. Microtiterplates and arrays are especially convenient because a large number ofassays can be carried out simultaneously, using small amounts ofreagents and samples.

[0243] The particular manner of binding of the composition is notcrucial so long as it is compatible with the reagents and overallmethods of the invention, maintains the activity of the composition andis nondiffusable. Preferred methods of binding include the use ofantibodies (which do not sterically block either the ligand binding siteor activation sequence when the protein is bound to the support), directbinding to “sticky” or ionic supports, chemical crosslinking, thesynthesis of the protein or agent on the surface, etc. Following bindingof the protein or agent, excess unbound material is removed by washing.The sample receiving areas may then be blocked through incubation withbovine serum albumin (BSA), casein or other innocuous protein or othermoiety.

[0244] In a preferred embodiment, the CA protein is bound to thesupport, and a candidate bioactive agent is added to the assay.Alternatively, the candidate agent is bound to the support and the CAprotein is added. Novel binding agents include specific antibodies,non-natural binding agents identified in screens of chemical libraries,peptide analogs, etc. Of particular interest are screening assays foragents that have a low toxicity for human cells. A wide variety ofassays may be used for this purpose, including labeled in vitroprotein-protein binding assays, electrophoretic mobility shift assays,immunoassays for protein binding, functional assays (phosphorylationassays, etc.) and the like.

[0245] The determination of the binding of the candidate bioactive agentto the CA protein may be done in a number of ways. In a preferredembodiment, the candidate bioactive agent is labeled, and bindingdetermined directly. For example, this may be done by attaching all or aportion of the CA protein to a solid support, adding a labeled candidateagent (for example a fluorescent label), washing off excess reagent, anddetermining whether the label is present on the solid support. Variousblocking and washing steps may be utilized as is known in the art.

[0246] By “labeled” herein is meant that the compound is either directlyor indirectly labeled with a label which provides a detectable signal,e.g. radioisotope, fluorescers, enzyme, antibodies, particles such asmagnetic particles, chemiluminescers, or specific binding molecules,etc. Specific binding molecules include pairs, such as biotin andstreptavidin, digoxin and antidigoxin etc. For the specific bindingmembers, the complementary member would normally be labeled with amolecule which provides for detection, in accordance with knownprocedures, as outlined above. The label can directly or indirectlyprovide a detectable signal.

[0247] In some embodiments, only one of the components is labeled. Forexample, the proteins (or proteinaceous candidate agents) may be labeledat tyrosine positions using ¹²⁵I, or with fluorophores. Alternatively,more than one component may be labeled with different labels; using ¹²⁵Ifor the proteins, for example, and a fluorophore for the candidateagents.

[0248] In a preferred embodiment, the binding of the candidate bioactiveagent is determined through the use of competitive binding assays. Inthis embodiment, the competitor is a binding moiety known to bind to thetarget molecule (i.e. CA protein), such as an antibody, peptide, bindingpartner, ligand, etc. Under certain circumstances, there may becompetitive binding as between the bioactive agent and the bindingmoiety, with the binding moiety displacing the bioactive agent.

[0249] In one embodiment, the candidate bioactive agent is labeled.Either the candidate bioactive agent, or the competitor, or both, isadded first to the protein for a time sufficient to allow binding, ifpresent. Incubations may be performed at any temperature whichfacilitates optimal activity, typically between 4 and 40° C. Incubationperiods are selected for optimum activity, but may also be optimized tofacilitate rapid high throughput screening. Typically between 0.1 and 1hour will be sufficient. Excess reagent is generally removed or washedaway. The second component is then added, and the presence or absence ofthe labeled component is followed, to indicate binding.

[0250] In a preferred embodiment, the competitor is added first,followed by the candidate bioactive agent. Displacement of thecompetitor is an indication that the candidate bioactive agent isbinding to the CA protein and thus is capable of binding to, andpotentially modulating, the activity of the CA protein. In thisembodiment, either component can be labeled. Thus, for example, if thecompetitor is labeled, the presence of label in the wash solutionindicates displacement by the agent. Alternatively, if the candidatebioactive agent is labeled, the presence of the label on the supportindicates displacement.

[0251] In an alternative embodiment, the candidate bioactive agent isadded first, with incubation and washing, followed by the competitor.The absence of binding by the competitor may indicate that the bioactiveagent is bound to the CA protein with a higher affinity. Thus, if thecandidate bioactive agent is labeled, the presence of the label on thesupport, coupled with a lack of competitor binding, may indicate thatthe candidate agent is capable of binding to the CA protein.

[0252] In a preferred embodiment, the methods comprise differentialscreening to identity bioactive agents that are capable of modulatingthe activity of the CA proteins. In this embodiment, the methodscomprise combining a CA protein and a competitor in a first sample. Asecond sample comprises a candidate bioactive agent, a CA protein and acompetitor. The binding of the competitor is determined for bothsamples, and a change, or difference in binding between the two samplesindicates the presence of an agent capable of binding to the CA proteinand potentially modulating its activity. That is, if the binding of thecompetitor is different in the second sample relative to the firstsample, the agent is capable of binding to the CA protein.

[0253] Alternatively, a preferred embodiment utilizes differentialscreening to identify drug candidates that bind to the native CAprotein, but cannot bind to modified CA proteins. The structure of theCA protein may be modeled, and used in rational drug design tosynthesize agents that interact with that site. Drug candidates thataffect CA bioactivity are also identified by screening drugs for theability to either enhance or reduce the activity of the protein.

[0254] Positive controls and negative controls may be used in theassays. Preferably all control and test samples are performed in atleast triplicate to obtain statistically significant results. Incubationof all samples is for a time sufficient for the binding of the agent tothe protein. Following incubation, all samples are washed free ofnon-specifically bound material and the amount of bound, generallylabeled agent determined. For example, where a radiolabel is employed,the samples may be counted in a scintillation counter to determine theamount of bound compound.

[0255] A variety of other reagents may be included in the screeningassays. These include reagents like salts, neutral proteins, e.g.albumin, detergents, etc which may be used to facilitate optimalprotein-protein binding and/or reduce non-specific or backgroundinteractions. Also reagents that otherwise improve the efficiency of theassay, such as protease inhibitors, nuclease inhibitors, anti-microbialagents, etc., may be used. The mixture of components may be added in anyorder that provides for the requisite binding.

[0256] Screening for agents that modulate the activity of CA proteinsmay also be done. In a preferred embodiment, methods for screening for abioactive agent capable of modulating the activity of CA proteinscomprise the steps of adding a candidate bioactive agent to a sample ofCA proteins, as above, and determining an alteration in the biologicalactivity of CA proteins. “Modulating the activity of a CA protein”includes an increase in activity, a decrease in activity, or a change inthe type or kind of activity present. Thus, in this embodiment, thecandidate agent should both bind to CA proteins (although this may notbe necessary), and alter its biological or biochemical activity asdefined herein. The methods include both in vitro screening methods, asare generally outlined above, and in vivo screening of cells foralterations in the presence, distribution, activity or amount of CAproteins.

[0257] Thus, in this embodiment, the methods comprise combining a CAsample and a candidate bioactive agent, and evaluating the effect on CAactivity. By “CA activity” or grammatical equivalents herein is meantone of the CA protein's biological activities, including, but notlimited to, its role in tumorigenesis, including cell division,preferably in lymphatic tissue, cell proliferation, tumor growth andtransformation of cells. In one embodiment, CA activity includesactivation of or by a protein encoded by a nucleic acid of Tables 1-6.An inhibitor of CA activity is the inhibition of any one or more CAactivities.

[0258] In a preferred embodiment, the activity of the CA protein isincreased; in another preferred embodiment, the activity of the CAprotein is decreased. Thus, bioactive agents that are antagonists arepreferred in some embodiments, and bioactive agents that are agonistsmay be preferred in other embodiments.

[0259] In a preferred embodiment, the invention provides methods forscreening for bioactive agents capable of modulating the activity of aCA protein. The methods comprise adding a candidate bioactive agent, asdefined above, to a cell comprising CA proteins. Preferred cell typesinclude almost any cell. The cells contain a recombinant nucleic acidthat encodes a CA protein. In a preferred embodiment, a library ofcandidate agents is tested on a plurality of cells.

[0260] In one aspect, the assays are evaluated in the presence orabsence or previous or subsequent exposure of physiological signals, forexample hormones, antibodies, peptides, antigens, cytokines, growthfactors, action potentials, pharmacological agents includingchemotherapeutics, radiation, carcinogenics, or other cells (i.e.cell-cell contacts). In another example, the determinations aredetermined at different stages of the cell cycle process.

[0261] In this way, bioactive agents are identified. Compounds withpharmacological activity are able to enhance or interfere with theactivity of the CA protein.

[0262] Applications of the Invention

[0263] In one embodiment, a method of inhibiting cancer cell division isprovided. In another embodiment, a method of inhibiting tumor growth isprovided. In a further embodiment, methods of treating cells orindividuals with cancer are provided.

[0264] In one embodiment, a method of inhibiting carcinoma cancer celldivision, is provided. The method comprises administration of acarcinoma cancer inhibitor. In oned embodiment, the carcinoma cell is alymphoma carcinoma, in another embodiment, the carcinoma cell is abreast camcer carcinoma.

[0265] In another embodiment, a method of inhibiting tumor growth isprovided. The method comprises administration of a carcinoma cancerinhibitor. In a particular embodiment, a method of inhibiting tumorgrowth in lymphatic tissue is provided comprising administration of alymphoma inhibitor. In another embodiment, a method of inhibiting tumorgrowth in mammary tissue is provided comprising administration of abreast cancer inhibitor.

[0266] The method comprises administration of a cancer inhibitor. Inparticular embodiments, the cancer inhibitor is an antisense molecule, apharmaceutical composition, a therapeutic agent or small molecule, or amonoclonal, polyclonal, chimeric or humanized antibody. In particularembodiments, a therapeutic agent is coupled with a an antibody,preferable a monoclonal antobody.

[0267] In other embodiments, methods for detection or diagnosis ofcancer cells in an individual are provided. In particular embodiments,the diagnostic/detection agent is a small molecule that pereferentiallybinds to a CAP according to the invention. In one embodiment, thediagnostic/detection agent is an antibody, preferably a monoclonalantibody, preferably linked to a detectable agent.

[0268] In other embodiments of the invention, animal models andtransgenic animals are provided, which find use in generating animalmodels of cancers, particularly lymphomas and carcinomas.

[0269] (a) Antisense Molecules

[0270] In one embodiment, the cancer inhibitor is an antisense molecule.Antisense molecules as used herein include antisense or senseoligonucleotides comprising a single-stranded nucleic acid sequence(either RNA or DNA) capable of binding to target mRNA (sense) or DNA(antisense) sequences for cancer molecules. Antisense or senseoligonucleotides, according to the present invention, comprise afragment generally at least about 14 nucleotides, preferably from about14 to 30 nucleotides. The ability to derive an antisense or a senseoligonucleotide, based upon a cDNA sequence encoding a given protein isdescribed in, for example, Stein and Cohen, Cancer Res. 48:2659, (1988)and van der Krol et al., BioTechniques 6:958, (1988).

[0271] Antisense molecules may be introduced into a cell containing thetarget nucleotide sequence by formation of a conjugate with a ligandbinding molecule, as described in WO 91/04753. Suitable ligand bindingmolecules include, but are not limited to, cell surface receptors,growth factors, other cytokines, or other ligands that bind to cellsurface receptors. Preferably, conjugation of the ligand bindingmolecule does not substantially interfere with the ability of the ligandbinding molecule to bind to its corresponding molecule or receptor, orblock entry of the sense or antisense oligonucleotide or its conjugatedversion into the cell. Alternatively, a sense or an antisenseoligonucleotide may be introduced into a cell containing the targetnucleic acid sequence by formation of an oligonucleotide-lipid complex,as described in WO 90/10448. It is understood that the use of antisensemolecules or knock out and knock in models may also be used in screeningassays as discussed above, in addition to methods of treatment.

[0272] (b) Pharmaceutical Compositions

[0273] Pharmaceutical compositions encompassed by the present inventioninclude as active agent, the polypeptides, polynucleotides, antisenseoligonucleotides, or antibodies of the invention disclosed herein in atherapeutically effective amount. An “effective amount” is an amountsufficient to effect beneficial or desired results, including clinicalresults. An effective amount can be administered in one or moreadministrations. For purposes of this invention, an effective amount ofan adenoviral vector is an amount that is sufficient to palliate,ameliorate, stabilize, reverse, slow or delay the progression of thedisease state.

[0274] The compositions can be used to treat cancer as well asmetastases of primary cancer. In addition, the pharmaceuticalcompositions can be used in conjunction with conventional methods ofcancer treatment, e.g., to sensitize tumors to radiation or conventionalchemotherapy. The terms “treatment”, “treating”, “treat” and the likeare used herein to generally refer to obtaining a desired pharmacologicand/or physiologic effect. The effect may be prophylactic in terms ofcompletely or partially preventing a disease or symptom thereof and/ormay be therapeutic in terms of a partial or complete stabilization orcure for a disease and/or adverse effect attributable to the disease.“Treatment” as used herein covers any treatment of a disease in amammal, particularly a human, and includes: (a) preventing the diseaseor symptom from occurring in a subject which may be predisposed to thedisease or symptom but has not yet been diagnosed as having it; (b)inhibiting the disease symptom, i.e., arresting its development; or (c)relieving the disease symptom, i.e., causing regression of the diseaseor symptom.

[0275] Where the pharmaceutical composition comprises an antibody thatspecifically binds to a gene product encoded by a differentiallyexpressed polynucleotide, the antibody can be coupled to a drug fordelivery to a treatment site or coupled to a detectable label tofacilitate imaging of a site comprising cancer cells, such as prostatecancer cells. Methods for coupling antibodies to drugs and detectablelabels are well known in the art, as are methods for imaging usingdetectable labels.

[0276] A “patient” for the purposes of the present invention includesboth humans and other animals, particularly mammals, and organisms. Thusthe methods are applicable to both human therapy and veterinaryapplications. In the preferred embodiment the patient is a mammal, andin the most preferred embodiment the patient is human.

[0277] The term “therapeutically effective amount” as used herein refersto an amount of a therapeutic agent to treat, ameliorate, or prevent adesired disease or condition, or to exhibit a detectable therapeutic orpreventative effect. The effect can be detected by, for example,chemical markers or antigen levels. Therapeutic effects also includereduction in physical symptoms, such as decreased body temperature. Theprecise effective amount for a subject will depend upon the subject'ssize and health, the nature and extent of the condition, and thetherapeutics or combination of therapeutics selected for administration.The effective amount for a given situation is determined by routineexperimentation and is within the judgment of the clinician. Forpurposes of the present invention, an effective dose will generally befrom about 0.01 mg/kg to about 5 mg/kg, or about 0.01 mg/kg to about 50mg/kg or about 0.05 mg/kg to about 10 mg/kg of the compositions of thepresent invention in the individual to which it is administered.

[0278] A pharmaceutical composition can also contain a pharmaceuticallyacceptable carrier. The term “pharmaceutically acceptable carrier”refers to a carrier for administration of a therapeutic agent, such asantibodies or a polypeptide, genes, and other therapeutic agents. Theterm refers to any pharmaceutical carrier that does not itself inducethe production of antibodies harmful to the individual receiving thecomposition, and which can be administered without undue toxicity.Suitable carriers can be large, slowly metabolized macromolecules suchas proteins, polysaccharides, polylactic acids, polyglycolic acids,polymeric amino acids, amino acid copolymers, and inactive virusparticles. Such carriers are well known to those of ordinary skill inthe art. Pharmaceutically acceptable carriers in therapeuticcompositions can include liquids such as water, saline, glycerol andethanol. Auxiliary substances, such as wetting or emulsifying agents, pHbuffering substances, and the like, can also be present in suchvehicles. Typically, the therapeutic compositions are prepared asinjectables, either as liquid solutions or suspensions; solid formssuitable for solution in, or suspension in, liquid vehicles prior toinjection can also be prepared. Liposomes are included within thedefinition of a pharmaceutically acceptable carrier. Pharmaceuticallyacceptable salts can also be present in the pharmaceutical composition,e.g., mineral acid salts such as hydrochlorides, hydrobromides,phosphates, sulfates, and the like; and the salts of organic acids suchas acetates, propionates, malonates, benzoates, and the like. A thoroughdiscussion of pharmaceutically acceptable excipients is available inRemington: The Science and Practice of Pharmacy (1995) Alfonso Gennaro,Lippincott, Williams, & Wilkins.

[0279] The pharmaceutical compositions can be prepared in various forms,such as granules, tablets, pills, suppositories, capsules, suspensions,salves, lotions and the like. Pharmaceutical grade organic or inorganiccarriers and/or diluents suitable for oral and topical use can be usedto make up compositions containing the therapeutically-active compounds.Diluents known to the art include aqueous media, vegetable and animaloils and fats. Stabilizing agents, wetting and emulsifying agents, saltsfor varying the osmotic pressure or buffers for securing an adequate pHvalue, and skin penetration enhancers can be used as auxiliary agents.

[0280] The pharmaceutical compositions of the present invention comprisea CA protein in a form suitable for administration to a patient. In thepreferred embodiment, the pharmaceutical compositions are in a watersoluble form, such as being present as pharmaceutically acceptablesalts, which is meant to include both acid and base addition salts.“Pharmaceutically acceptable acid addition salt” refers to those saltsthat retain the biological effectiveness of the free bases and that arenot biologically or otherwise undesirable, formed with inorganic acidssuch as hydrochloric acid, hydrobromic acid, sulfuric acid, nitric acid,phosphoric acid and the like, and organic acids such as acetic acid,propionic acid, glycolic acid, pyruvic acid, oxalic acid, maleic acid,malonic acid, succinic acid, fumaric acid, tartaric acid, citric acid,benzoic acid, cinnamic acid, mandelic acid, methanesulfonic acid,ethanesulfonic acid, p-toluenesulfonic acid, salicylic acid and thelike. “Pharmaceutically acceptable base addition salts” include thosederived from inorganic bases such as sodium, potassium, lithium,ammonium, calcium, magnesium, iron, zinc, copper, manganese, aluminumsalts and the like. Particularly preferred are the ammonium, potassium,sodium, calcium, and magnesium salts. Salts derived frompharmaceutically acceptable organic non-toxic bases include salts ofprimary, secondary, and tertiary amines, substituted amines includingnaturally occurring substituted amines, cyclic amines and basic ionexchange resins, such as isopropylamine, trimethylamine, diethylamine,triethylamine, tripropylamine, and ethanolamine.

[0281] The pharmaceutical compositions may also include one or more ofthe following: carrier proteins such as serum albumin; buffers; fillerssuch as microcrystalline cellulose, lactose, corn and other starches;binding agents; sweeteners and other flavoring agents; coloring agents;and polyethylene glycol. Additives are well known in the art, and areused in a variety of formulations.

[0282] The compounds having the desired pharmacological activity may beadministered in a physiologically acceptable carrier to a host, aspreviously described. The agents may be administered in a variety ofways, orally, parenterally e.g., subcutaneously, intraperitoneally,intravascularly, etc. Depending upon the manner of introduction, thecompounds may be formulated in a variety of ways. The concentration oftherapeutically active compound in the formulation may vary from about0.1-100% wgt/vol. Once formulated, the compositions contemplated by theinvention can be (1) administered directly to the subject (e.g., aspolynucleotide, polypeptides, small molecule agonists or antagonists,and the like); or (2) delivered ex vivo, to cells derived from thesubject (e.g., as in ex vivo gene therapy). Direct delivery of thecompositions will generally be accomplished by parenteral injection,e.g., subcutaneously, intraperitoneally, intravenously orintramuscularly, intratumoral or to the interstitial space of a tissue.Other modes of administration include oral and pulmonary administration,suppositories, and transdermal applications, needles, and gene guns orhyposprays. Dosage treatment can be a single dose schedule or a multipledose schedule.

[0283] Methods for the ex vivo delivery and reimplantation oftransformed cells into a subject are known in the art and described ine.g., International Publication No. WO 93/14778. Examples of cellsuseful in ex vivo applications include, for example, stem cells,particularly hematopoetic, lymph cells, macrophages, dendritic cells, ortumor cells. Generally, delivery of nucleic acids for both ex vivo andin vitro applications can be accomplished by, for example,dextran-mediated transfection, calcium phosphate precipitation,polybrene mediated transfection, protoplast fusion, electroporation,encapsulation of the polynucleotide(s) in liposomes, and directmicroinjection of the DNA into nuclei, all well known in the art.

[0284] Once differential expression of a gene corresponding to a CApolynucleotide described herein has been found to correlate with aproliferative disorder, such as neoplasia, dysplasia, and hyperplasia,the disorder can be amenable to treatment by administration of atherapeutic agent based on the provided polynucleotide, correspondingpolypeptide or other corresponding molecule (e.g., antisense, ribozyme,etc.). In other embodiments, the disorder can be amenable to treatmentby administration of a small molecule drug that, for example, serves asan inhibitor (antagonist) of the function of the encoded gene product ofa gene having increased expression in cancerous cells relative to normalcells or as an agonist for gene products that are decreased inexpression in cancerous cells (e.g., to promote the activity of geneproducts that act as tumor suppressors).

[0285] The dose and the means of administration of the inventivepharmaceutical compositions are determined based on the specificqualities of the therapeutic composition, the condition, age, and weightof the patient, the progression of the disease, and other relevantfactors. For example, administration of polynucleotide therapeuticcompositions agents includes local or systemic administration, includinginjection, oral administration, particle gun or catheterizedadministration, and topical administration. Preferably, the therapeuticpolynucleotide composition contains an expression construct comprising apromoter operably linked to a polynucleotide of at least 12, 22, 25, 30,or 35 contiguous nt of the polynucleotide disclosed herein. Variousmethods can be used to administer the therapeutic composition directlyto a specific site in the body. For example, a small metastatic lesionis located and the therapeutic composition injected several times inseveral different locations within the body of tumor. Alternatively,arteries that serve a tumor are identified, and the therapeuticcomposition injected into such an artery, in order to deliver thecomposition directly into the tumor. A tumor that has a necrotic centeris aspirated and the composition injected directly into the now emptycenter of the tumor. An antisense composition is directly administeredto the surface of the tumor, for example, by topical application of thecomposition. X-ray imaging is used to assist in certain of the abovedelivery methods.

[0286] Targeted delivery of therapeutic compositions containing anantisense polynucleotide, subgenomic polynucleotides, or antibodies tospecific tissues can also be used. Receptor-mediated DNA deliverytechniques are described in, for example, Findeis et al., TrendsBiotechnol. (1993) 11:202; Chiou et al., Gene Therapeutics: Methods AndApplications Of Direct Gene Transfer (J. A. Wolff, ed.) (1994); Wu etal., J. Biol. Chem. (1988) 263:621; Wu et al., J. Biol. Chem. (1994)269:542; Zenke et al., Proc. Natl. Acad. Sci. (USA) (1990) 87:3655; Wuet al., J. Biol. Chem. (1991) 266:338. Therapeutic compositionscontaining a polynucleotide are administered in a range of about 100 ngto about 200 mg of DNA for local administration in a gene therapyprotocol. Concentration ranges of about 500 ng to about 50 mg, about 1μg to about 2 mg, about 5 μg to about 500 μg, and about 20 μg to about100 μg of DNA can also be used during a gene therapy protocol. Factorssuch as method of action (e.g., for enhancing or inhibiting levels ofthe encoded gene product) and efficacy of transformation and expressionare considerations that will affect the dosage required for ultimateefficacy of the antisense subgenomic polynucleotides. Where greaterexpression is desired over a larger area of tissue, larger amounts ofantisense subgenomic polynucleotides or the same amounts re-administeredin a successive protocol of administrations, or several administrationsto different adjacent or close tissue portions of, for example, a tumorsite, may be required to effect a positive therapeutic outcome. In allcases, routine experimentation in clinical trials will determinespecific ranges for optimal therapeutic effect.

[0287] The therapeutic polynucleotides and polypeptides of the presentinvention can be delivered using gene delivery vehicles. The genedelivery vehicle can be of viral or non-viral origin (see generally,Jolly, Cancer Gene Therapy (1994) 1:51; Kimura, Human Gene Therapy(1994) 5:845; Connelly, Human Gene Therapy (1995) 1:185; and Kaplitt,Nature Genetics (1994) 6:148). Expression of such coding sequences canbe induced using endogenous mammalian or heterologous promoters.Expression of the coding sequence can be either constitutive orregulated.

[0288] Viral-based vectors for delivery of a desired polynucleotide andexpression in a desired cell are well known in the art. Exemplaryviral-based vehicles include, but are not limited to, recombinantretroviruses (see, e.g., WO 90/07936; WO 94/03622; WO 93/25698; WO93/25234; U.S. Pat. No. 5,219,740; WO 93/11230; WO 93/10218; U.S. Pat.No. 4,777,127; GB Patent No. 2,200,651; EP 0 345 242; and WO 91/02805),alphavirus-based vectors (e.g., Sindbis virus vectors, Semliki forestvirus (ATCC VR-67; ATCC VR-1247), Ross River virus (ATCC VR-373; ATCCVR-1246) and Venezuelan equine encephalitis virus (ATCC VR-923; ATCCVR-1250; ATCC VR 1249; ATCC VR-532)), and adeno-associated virus (AAV)vectors (see, e.g., WO 94/12649, WO 93/03769; WO 93/19191; WO 94/28938;WO 95/11984 and WO 95/00655). Administration of DNA linked to killedadenovirus as described in Curiel, Hum. Gene Ther. (1992) 3:147 can alsobe employed.

[0289] Non-viral delivery vehicles and methods can also be employed,including, but not limited to, polycationic condensed DNA linked orunlinked to killed adenovirus alone (see, e.g., Curiel, Hum. Gene Ther.(1992) 3:147); ligand-linked DNA (see, e.g., Wu, J. Biol. Chem. (1989)264:16985); eukaryotic cell delivery vehicles cells (see, e.g., U.S.Pat. No. 5,814,482; WO 95/07994; WO 96/17072; WO 95/30763; and WO97/42338) and nucleic charge neutralization or fusion with cellmembranes. Naked DNA can also be employed. Exemplary naked DNAintroduction methods are described in WO 90/11092 and U.S. Pat. No.5,580,859. Liposomes that can act as gene delivery vehicles aredescribed in U.S. Pat. No. 5,422,120; WO 95/13796; WO 94/23697; WO91/14445; and EP 0524968. Additional approaches are described in Philip,Mol. Cell Biol. (1994) 14:2411, and in Woffendin, Proc. Natl. Acad. Sci.(1994) 91:1581.

[0290] Further non-viral delivery suitable for use includes mechanicaldelivery systems such as the approach described in Woffendin et al.,Proc. Natl. Acad. Sci. USA (1994) 91(24):11581. Moreover, the codingsequence and the product of expression of such can be delivered throughdeposition of photopolymerized hydrogel materials or use of ionizingradiation (see, e.g., U.S. Pat. No. 5,206,152 and WO 92/11033). Otherconventional methods for gene delivery that can be used for delivery ofthe coding sequence include, for example, use of hand-held gene transferparticle gun (see, e.g., U.S. Pat. No. 5,149,655); use of ionizingradiation for activating transferred gene (see, e.g., U.S. Pat. No.5,206,152 and WO 92/11033).

[0291] The administration of the CA proteins and modulators of thepresent invention can be done in a variety of ways as discussed above,including, but not limited to, orally, subcutaneously, intravenously,intranasally, transdermally, intraperitoneally, intramuscularly,intrapulmonary, vaginally, rectally, or intraocularly. In someinstances, for example, in the treatment of wounds and inflammation, theCA proteins and modulators may be directly applied as a solution orspray.

[0292] In a preferred embodiment, CA proteins and modulators areadministered as therapeutic agents, and can be formulated as outlinedabove. Similarly, CA genes (including both the full-length sequence,partial sequences, or regulatory sequences of the CA coding regions) canbe administered in gene therapy applications, as is known in the art.These CA genes can include antisense applications, either as genetherapy (i.e. for incorporation into the genome) or as antisensecompositions, as will be appreciated by those in the art.

[0293] Thus, in one embodiment, methods of modulating CA gene activityin cells or organisms are provided. In one embodiment, the methodscomprise administering to a cell an anti-CA antibody that reduces oreliminates the biological activity of an endogenous CA protein.Alternatively, the methods comprise administering to a cell or organisma recombinant nucleic acid encoding a CA protein. As will be appreciatedby those in the art, this may be accomplished in any number of ways. Ina preferred embodiment, for example when the CA sequence isdown-regulated in cancer, the activity of the CA gene product isincreased by increasing the amount of CA expression in the cell, forexample by overexpressing the endogenous CA gene or by administering agene encoding the CA sequence, using known gene-therapy techniques. In apreferred embodiment, the gene therapy techniques include theincorporation of the exogenous gene using enhanced homologousrecombination (EHR), for example as described in PCT/US93/03868, herebyincorporated by reference in its entirety. Alternatively, for examplewhen the CA sequence is up-regulated in cancer, the activity of theendogenous CA gene is decreased, for example by the administration of aCA antisense nucleic acid.

[0294] (c) Vaccines

[0295] In a preferred embodiment, CA genes are administered as DNAvaccines, either single genes or combinations of CA genes. Naked DNAvaccines are generally known in the art. Brower, Nature Biotechnology,16:1304-1305 (1998).

[0296] In one embodiment, CA genes of the present invention are used asDNA vaccines. Methods for the use of genes as DNA vaccines are wellknown to one of ordinary skill in the art, and include placing a CA geneor portion of a CA gene under the control of a promoter for expressionin a patient with cancer. The CA gene used for DNA vaccines can encodefull-length CA proteins, but more preferably encodes portions of the CAproteins including peptides derived from the CA protein. In a preferredembodiment a patient is immunized with a DNA vaccine comprising aplurality of nucleotide sequences derived from a CA gene. Similarly, itis possible to immunize a patient with a plurality of CA genes orportions thereof. Without being bound by theory, expression of thepolypeptide encoded by the DNA vaccine, cytotoxic T-cells, helperT-cells and antibodies are induced that recognize and destroy oreliminate cells expressing CA proteins.

[0297] In a preferred embodiment, the DNA vaccines include a geneencoding an adjuvant molecule with the DNA vaccine. Such adjuvantmolecules include cytokines that increase the immunogenic response tothe CA polypeptide encoded by the DNA vaccine. Additional or alternativeadjuvants are known to those of ordinary skill in the art and find usein the invention.

[0298] (d) Antibodies

[0299] In one embodiment, a cancer inhibitor is an antibody as discussedabove. In one embodiment, the CA-proteins of the present invention maybe used to generate polyclonal and monoclonal antibodies to CA proteins,which are useful as described herein. Similarly, the CA proteins can becoupled, using standard technology, to affinity chromatography columns.These columns may then be used to purify CA antibodies. In a preferredembodiment, the antibodies are generated to epitopes unique to a CAprotein; that is, the antibodies show little or no cross-reactivity toother proteins. These antibodies find use in a number of applications.For example, the CA antibodies may be coupled to standard affinitychromatography columns and used to purify CA proteins. The antibodiesmay also be used therapeutically as blocking polypeptides, as outlinedabove, since they will specifically bind to the CA protein.

[0300] The present invention further provides methods for detecting thepresence of and/or measuring a level of a polypeptide in a biologicalsample, which CA polypeptide is encoded by a CA polynucleotide that isdifferentially expressed in a cancer cell, using an antibody specificfor the encoded polypeptide. The methods generally comprise: a)contacting the sample with an antibody specific for a polypeptideencoded by a CA polynucleotide that is differentially expressed in aprostate cancer cell; and b) detecting binding between the antibody andmolecules of the sample.

[0301] Detection of specific binding of the antibody specific for theencoded cancer-associated polypeptide, when compared to a suitablecontrol is an indication that encoded polypeptide is present in thesample. Suitable controls include a sample known not to contain theencoded CA polypeptide or known not to contain elevated levels of thepolypeptide; such as normal tissue, and a sample contacted with anantibody not specific for the encoded polypeptide, e.g., ananti-idiotype antibody. A variety of methods to detect specificantibody-antigen interactions are known in the art and can be used inthe method, including, but not limited to, standard immunohistologicalmethods, immunoprecipitation, an enzyme immunoassay, and aradioimmunoassay. In general, the specific antibody will be detectablylabeled, either directly or indirectly. Direct labels includeradioisotopes; enzymes whose products are detectable (e.g., luciferase,β-galactosidase, and the like); fluorescent labels (e.g., fluoresceinisothiocyanate, rhodamine, phycoerythrin, and the like); fluorescenceemitting metals, e.g., ¹⁵²Eu, or others of the lanthanide series,attached to the antibody through metal chelating groups such as EDTA;chemiluminescent compounds, e.g., luminol, isoluminol, acridinium salts,and the like; bioluminescent compounds, e.g., luciferin, aequorin (greenfluorescent protein), and the like. The antibody may be attached(coupled) to an insoluble support, such as a polystyrene plate or abead. Indirect labels include second antibodies specific for antibodiesspecific for the encoded polypeptide (“first specific antibody”),wherein the second antibody is labeled as described above; and membersof specific binding pairs, e.g., biotin-avidin, and the like. Thebiological sample may be brought into contact with and immobilized on asolid support or carrier, such as nitrocellulose, that is capable ofimmobilizing cells, cell particles, or soluble proteins. The support maythen be washed with suitable buffers, followed by contacting with adetectably-labeled first specific antibody. Detection methods are knownin the art and will be chosen as appropriate to the signal emitted bythe detectable label. Detection is generally accomplished in comparisonto suitable controls, and to appropriate standards.

[0302] In some embodiments, the methods are adapted for use in vivo,e.g., to locate or identify sites where cancer cells are present. Inthese embodiments, a detectably-labeled moiety, e.g., an antibody, whichis specific for a cancer-associated polypeptide is administered to anindividual (e.g., by injection), and labeled cells are located usingstandard imaging techniques, including, but not limited to, magneticresonance imaging, computed tomography scanning, and the like. In thismanner, cancer cells are differentially labeled.

[0303] (e) Detection and Diagnosis of Cancers

[0304] Without being bound by theory, it appears that the various CAsequences are important in cancers. Accordingly, disorders based onmutant or variant CA genes may be determined. In one embodiment, theinvention provides methods for identifying cells containing variant CAgenes comprising determining all or part of the sequence of at least oneendogenous CA genes in a cell. As will be appreciated by those in theart, this may be done using any number of sequencing techniques. In apreferred embodiment, the invention provides methods of identifying theCA genotype of an individual comprising determining all or part of thesequence of at least one CA gene of the individual. This is generallydone in at least one tissue of the individual, and may include theevaluation of a number of tissues or different samples of the sametissue. The method may include comparing the sequence of the sequencedCA gene to a known CA gene, i.e., a wild-type gene. As will beappreciated by those in the art, alterations in the sequence of some CAgenes can be an indication of either the presence of the disease, orpropensity to develop the disease, or prognosis evaluations.

[0305] The sequence of all or part of the CA gene can then be comparedto the sequence of a known CA gene to determine if any differencesexist. This can be done using any number of known homology programs,such as Bestfit, etc. In a preferred embodiment, the presence of adifference in the sequence between the CA gene of the patient and theknown CA gene is indicative of a disease state or a propensity for adisease state, as outlined herein.

[0306] In a preferred embodiment, the CA genes are used as probes todetermine the number, of copies of the CA gene in the genome. Forexample, some cancers exhibit chromosomal deletions or insertions,resulting in an alteration in the copy number of a gene.

[0307] In another preferred embodiment CA genes are used as probes todetermine the chromosomal location of the CA genes. Information such aschromosomal location finds use in providing a diagnosis or prognosis inparticular when chromosomal abnormalities such as translocations, andthe like are identified in CA gene loci.

[0308] The present invention provides methods of using thepolynucleotides described herein for detecting cancer cells,facilitating diagnosis of cancer and the severity of a cancer (e.g.,tumor grade, tumor burden, and the like) in a subject, facilitating adetermination of the prognosis of a subject, and assessing theresponsiveness of the subject to therapy (e.g., by providing a measureof therapeutic effect through, for example, assessing tumor burdenduring or following a chemotherapeutic regimen). Detection can be basedon detection of a polynucleotide that is differentially expressed in acancer cell, and/or detection of a polypeptide encoded by apolynucleotide that is differentially expressed in a cancer cell. Thedetection methods of the invention can be conducted in vitro or in vivo,on isolated cells, or in whole tissues or a bodily fluid e.g., blood,plasma, serum, urine, and the like).

[0309] In some embodiments, methods are provided for detecting a cancercell by detecting expression in the cell of a transcript that isdifferentially expressed in a cancer cell. Any of a variety of knownmethods can be used for detection, including, but not limited to,detection of a transcript by hybridization with a polynucleotide thathybridizes to a polynucleotide that is differentially expressed in aprostate cancer cell; detection of a transcript by a polymerase chainreaction using specific oligonucleotide primers; in situ hybridizationof a cell using as a probe a polynucleotide that hybridizes to a genethat is differentially expressed in a prostate cancer cell. The methodscan be used to detect and/or measure mRNA levels of a gene that isdifferentially expressed in a cancer cell. In some embodiments, themethods comprise: a) contacting a sample with a polynucleotide thatcorresponds to a differentially expressed gene described herein underconditions that allow hybridization; and b) detecting hybridization, ifany.

[0310] Detection of differential hybridization, when compared to asuitable control, is an indication of the presence in the sample of apolynucleotide that is differentially expressed in a cancer cell.Appropriate controls include, for example, a sample that is known not tocontain a polynucleotide that is differentially expressed in a cancercell, and use of a labeled polynucleotide of the same “sense” as thepolynucleotide that is differentially expressed in the cancer cell.Conditions that allow hybridization are known in the art, and have beendescribed in more detail above. Detection can also be accomplished byany known method, including, but not limited to, in situ hybridization,PCR (polymerase chain reaction), RT-PCR (reverse transcription-PCR),TMA, bDNA, and Nasbau and “Northern” or RNA blotting, or combinations ofsuch techniques, using a suitably labeled polynucleotide. A variety oflabels and labeling methods for polynucleotides are known in the art andcan be used in the assay methods of the invention. Specificity ofhybridization can be determined by comparison to appropriate controls.

[0311] Polynucleotides generally comprising at least 10 nt, at least 12nt or at least 15 contiguous nucleotides of a polynucleotide providedherein, such as, for example, those having the sequence as depicted inTables 1-6, are used for a variety of purposes, such as probes fordetection of and/or measurement of, transcription levels of apolynucleotide that is differentially expressed in a prostate cancercell. As will be readily appreciated by the ordinarily skilled artisan,the probe can be detectably labeled and contacted with, for example, anarray comprising immobilized polynucleotides obtained from a test sample(e.g., mRNA). Alternatively, the probe can be immobilized on an arrayand the test sample detectably labeled. These and other variations ofthe methods of the invention are well within the skill in the art andare within the scope of the invention.

[0312] Nucleotide probes are used to detect expression of a genecorresponding to the provided polynucleotide. In Northern blots, mRNA isseparated electrophoretically and contacted with a probe. A probe isdetected as hybridizing to an mRNA species of a particular size. Theamount of hybridization can be quantitated to determine relative amountsof expression, for example under a particular condition. Probes are usedfor in situ hybridization to cells to detect expression. Probes can alsobe used in vivo for diagnostic detection of hybridizing sequences.Probes are typically labeled with a radioactive isotope. Other types ofdetectable labels can be used such as chromophores, fluorophores, andenzymes. Other examples of nucleotide hybridization assays are describedin WO92/02526 and U.S. Pat. No. 5,124,246.

[0313] PCR is another means for detecting small amounts of targetnucleic acids (see, e.g., Mullis et al., Meth. Enzymol. (1987) 155:335;U.S. Pat. No. 4,683,195; and U.S. Pat. No. 4,683,202). Two primeroligonucleotides that hybridize with the target nucleic acids are usedto prime the reaction. The primers can be composed of sequence within or3′ and 5′ to the CA polynucleotides disclosed herein. Alternatively, ifthe primers are 3′ and 5′ to these polynucleotides, they need nothybridize to them or the complements. After amplification of the targetwith a thermostable polymerase, the amplified target nucleic acids canbe detected by methods known in the art, e.g., Southern blot. mRNA orcDNA can also be detected by traditional blotting techniques (e.g.,Southern blot, Northern blot, etc.) described in Sambrook et al.,“Molecular Cloning: A Laboratory Manual” (New York, Cold Spring HarborLaboratory, 1989) (e.g., without PCR amplification). In general, mRNA orcDNA generated from mRNA using a polymerase, enzyme can be purified andseparated using gel electrophoresis, and transferred to a solid support,such as nitrocellulose. The solid support is exposed to a labeled probe,washed to remove any unhybridized probe, and duplexes containing thelabeled probe are detected.

[0314] Methods using PCR amplification can be performed on the DNA froma single cell, although it is convenient to use at least about 10⁵cells. The use of the polymerase chain reaction is described in Saiki etal. (1985) Science 239:487, and a review of current techniques may befound in Sambrook, et al. Molecular Cloning: A Laboratory Manual, CSHPress 1989, pp.14.2-14.33. A detectable label may be included in theamplification reaction. Suitable detectable labels includefluorochromes,(e.g. fluorescein isothiocyanate (FITC), rhodamine, TexasRed, phycoerythrin, allophycocyanin, 6-carboxyfluorescein (6-FAM),2′,7′-dimethoxy-4′,5′-dichloro-6-carboxyfluorescein,6-carboxy-X-rhodamine (ROX),6-carboxy-2′,4′,7′,4,7-hexachlorofluorescein (HEX), 5-carboxyfluorescein(5-FAM) or N,N,N′,N′-tetramethyl-6-carboxyrhodamine (TAMRA)),radioactive labels, (e.g. ³²P, ³⁵S, ³H, etc.), and the like. The labelmay be a two stage system, where the polynucleotides is conjugated tobiotin, haptens, etc. having a high affinity binding partner, e.g.avidin, specific antibodies, etc., where the binding partner isconjugated to a detectable label. The label may be conjugated to one orboth of the primers. Alternatively, the pool of nucleotides used in theamplification is labeled, so as to incorporate the label into theamplification product.

[0315] The detection methods can be provided as part of a kit. Thus, theinvention further provides kits for detecting the presence and/or alevel of a polynucleotide that is differentially expressed in a cancercell (e.g., by detection of an mRNA encoded by the differentiallyexpressed gene of interest), and/or a polypeptide encoded thereby, in abiological sample. Procedures using these kits can be performed byclinical laboratories, experimental laboratories, medical practitioners,or private individuals. The kits of the invention for detecting apolypeptide encoded by a polynucleotide that is differentially expressedin a cancer cell may comprise a moiety that specifically binds thepolypeptide, which may be an antibody that binds the polypeptide orfragment thereof. The kits of the invention used for detecting apolynucleotide that is differentially expressed in a prostate cancercell may comprise a moiety that specifically hybridizes to such apolynucleotide. The kit may optionally provide additional componentsthat are useful in the procedure, including, but not limited to,buffers, developing reagents, labels, reacting surfaces, means fordetection, control samples, standards, instructions, and interpretiveinformation. Accordingly, the present invention provides kits fordetecting prostate cancer comprising at least one of polynucleotideshaving the sequence as shown in Tables 1-6 or fragments thereof.

[0316] The present invention further relates to methods ofdetecting/diagnosing a neoplastic or preneoplastic condition in a mammal(for example, a human). “Diagnosis” as used herein generally includesdetermination of a subject's susceptibility to a disease or disorder,determination as to whether a subject is presently affected by a diseaseor disorder, prognosis of a subject affected by a disease or disorder(e.g., identification of pre-metastatic or metastatic cancerous states,stages of cancer, or responsiveness of cancer to therapy), andtherametrics (e.g., monitoring a subject's condition to provideinformation as to the effect or efficacy of therapy).

[0317] The terms “treatment”, “treating”, “treat” and the like are usedherein to generally refer to obtaining a desired pharmacologic and/orphysiologic effect. The effect may be prophylactic in terms ofcompletely or partially preventing a disease or symptom thereof and/ormay be therapeutic in terms of a partial or complete stabilization orcure for a disease and/or adverse effect attributable to the disease.“Treatment” as used herein covers any treatment of a disease in amammal, particularly a human, and includes: (a) preventing the diseaseor symptom from occurring in a subject which may be predisposed to thedisease or symptom but has not yet been diagnosed as having it; (b)inhibiting the disease symptom, i.e., arresting its development; or (c)relieving the disease symptom, i.e., causing regression of the diseaseor symptom.

[0318] An “effective amount” is an amount sufficient to effectbeneficial or desired results, including clinical results. An effectiveamount can be administered in one or more administrations.

[0319] A “cell sample” encompasses a variety of sample types obtainedfrom an individual and can be used in a diagnostic or monitoring assay.The definition encompasses blood and other liquid samples of biologicalorigin, solid tissue samples such as a biopsy specimen or tissuecultures or cells derived therefrom, and the progeny thereof. Thedefinition also includes samples that have been manipulated in any wayafter their procurement, such as by treatment with reagents,solubilization, or enrichment for certain components, such as proteinsor polynucleotides. The term “cell sample” encompasses a clinicalsample, and also includes cells in culture, cell supernatants, celllysates, serum, plasma, biological fluid, and tissue samples.

[0320] As used herein, the terms “neoplastic cells”, “neoplasia”,“tumor”, “tumor cells”, “cancer” and “cancer cells”, (usedinterchangeably) refer to cells which exhibit relatively autonomousgrowth, so that they exhibit an aberrant growth phenotype characterizedby a significant loss of control of cell proliferation (i.e.,de-regulated cell division). Neoplastic cells can be malignant orbenign.

[0321] The terms “individual,” “subject,” “host,” and “patient,” areused interchangeably herein and refer to any mammalian subject for whomdiagnosis, treatment, or therapy is desired, particularly humans. Othersubjects may include cattle, dogs, cats, guinea pigs, rabbits, rats,mice, horses, and so on. Examples of conditions that can bedetected/diagnosed in accordance with these methods include cancers.Polynucleotides corresponding to genes that exhibit the appropriateexpression pattern can be used to detect cancer in a subject. For areview of markers of cancer, see, e.g., Hanahan et al. Cell 100:57-70(2000).

[0322] One detection/diagnostic method comprises: (a) obtaining from amammal (e.g., a human) a biological sample, (b) detecting the presencein the sample of a CA protein and (c) comparing the amount of productpresent with that in a control sample. In accordance with this method,the presence in the sample of elevated levels of a CA gene productindicates that the subject has a neoplastic or preneoplastic condition.

[0323] Biological samples suitable for use in this method includebiological fluids such as serum, plasma, pleural effusions, urine andcerebro-spinal fluid, CSF, tissue samples (e.g., mammary tumor orprostate tissue slices) can also be used in the method of the invention,including samples derived from biopsies. Cell cultures or cell extractsderived, for example, from tissue biopsies can also be used.

[0324] The compound is preferably a binding protein, e.g., an antibody,polyclonal or monoclonal, or antigen binding fragment thereof, which canbe labeled with a detectable marker (e.g., fluorophore, chromophore orisotope, etc). Where appropriate, the compound can be attached to asolid support such as a bead, plate, filter, resin, etc. Determinationof formation of the complex can be effected by contacting the complexwith a further compound (e.g., an antibody) that specifically binds tothe first compound (or complex). Like the first compound, the furthercompound can be attached to a solid support and/or can be labeled with adetectable marker.

[0325] The identification of elevated levels of CA protein in accordancewith the present invention makes possible the identification of subjects(patients) that are likely to benefit from adjuvant therapy. Forexample, a biological sample from a post primary therapy subject (e.g.,subject having undergone surgery) can be screened for the presence ofcirculating CA protein, the presence of elevated levels of the protein,determined by studies of normal populations, being indicative ofresidual tumor tissue. Similarly, tissue from the cut site of asurgically removed tumor can be examined (e.g., by immunofluorescence),the presence of elevated levels of product (relative to the surroundingtissue) being indicative of incomplete removal of the tumor. The abilityto identify such subjects makes it possible to tailor therapy to theneeds of the particular subject. Subjects undergoing non-surgicaltherapy, e.g., chemotherapy or radiation therapy, can also be monitored,the presence in samples from such subjects of elevated levels of CAprotein being indicative of the need for continued treatment. Staging ofthe disease (for example, for purposes of optimizing treatment regimens)can also be effected, for example, by biopsy e.g., with antibodyspecific for a CA protein.

[0326] (f) Animal Models and Transgenics

[0327] In another preferred embodiment CA genes find use in generatinganimal models of cancers, particularly lymphomas and carcinomas. As isappreciated by one of ordinary skill in the art, when the CA geneidentified is repressed or diminished in CA tissue, gene therapytechnology wherein antisense RNA directed to the CA gene will alsodiminish or repress expression of the gene. An animal generated as suchserves as an animal model of CA that finds use in screening bioactivedrug candidates. Similarly, gene knockout technology, for example as aresult of homologous recombination with an appropriate gene targetingvector, will result in the absence of the CA protein. When desired,tissue-specific expression or knockout of the CA protein may benecessary.

[0328] It is also possible that the CA protein is overexpressed incancer. As such, transgenic animals can be generated that overexpressthe CA protein. Depending on the desired expression level, promoters ofvarious strengths can be employed to express the transgene. Also, thenumber of copies of the integrated transgene can be determined andcompared for a determination of the expression level of the transgene.Animals generated by such methods find use as animal models of CA andare additionally useful in screening for bioactive molecules to treatcancer.

[0329] (g) Characterization of CA Sequences

[0330] The CA nucleic acid sequences of the invention are depicted inTables 1-6. The sequences in each Table include genomic DNA sequence,sequence corresponding to the mRNA and amino acid sequences of theproteins encoded by the mRNA for both mouse and human genes. Thedifferent sequences are assigned the following SEQ ID Nos: TABLE 1(mouse gene: Fscn1; human gene SNL) Mouse genomic sequence (SEQ IDNO: 1) Mouse mRNA sequence (SEQ ID NO: 2) Mouse coding sequence (SEQ IDNO: 3) Human genomic sequence (SEQ ID NO: 4) Human mRNA sequence (SEQ IDNO: 5) Human coding sequence (SEQ ID NO: 6) MOUSE SEQUENCE - GENOMIC(SEQ ID NO: 1)CCTCTCAAACTCTTGGTAATTCTCCTGCTTCGGCACGCTGGGGACTGGGACTACACCTGTGTGCCACCATGGCTGGCTATTTCTCTCTCTTGAACACTGGAAGAGTGCTCAGAGTTTACTGGATCTGGGAGAAGCTCGAGGCTGGGTTATGGAAGCCGGCTCTGCTTGCTCCAGCTCAGGGAGGAGTTGCCTGAGGGCCAGGCACTTCGAAGGACAGATGGGACCCAAGGCCAGACACTGGGCCCCAGCTCACCAGAAGTGGAGCCCTGACTGTCTCTGAGAGGGTAAGCTGGGGTGGCTGCCAGGCGGGCAAGGCCAAAGCCTGGCAGCAGCCGGTGGCCCCTCTTCTGGCAGAGATATCTTGGCATGAGCCTGGCTCTGCCCATGACACTAAAGTGCCCTCTTAATTAGCCAGGCTCTTGCCAAGCACTGGCCACGATTGCCTTGTTTCACAGAATTCACCTTCGACTGGCACAGATGGGGAGGGTGGATAGCCCGGTGTTTTGTCTTTCTTCTAGGGGAGCTGGGCTCAAGGGCAGGACTCCTGGGCCAGCCCAGGTTTTTCCCTCAGAAACCACAGCATGAATACTGGCATGATGGAGCACACCTGTAATCAGCAGAAATTGAGACAGGAAGATTGTTGAGAATTTGAGGCCAACCTAGGCTAAATAGGGAGACCCTATCTCTACACACTCCCCCTCCCCCCGCCCCTGGAAATGCTGGAGGGTCTGGGGAAGATGGCTCAGTGGTTAAGGGCACTTGCTGCTCTTGCAGGGGACCCAAGTTTGATTCCCAGCATCTATAACTTGGTGGCTCACAATTCCAGTTCCAGGCACTCTGACACCTTCCTGTGGTCTGCAAGGCACCTGCATTCATTCTCACGTGCATGCGCACACACATGCGCGCGCGCACACACACACACACACACACACACACATCTCATAAATACAAATAAAATAAATCTTGAAAACAACAGTGACAACAACACATGCTGAACATGGTGGTGCTCCTGACATGGTGGTGCTCCTGACATGGTGGTGCTCCTGACATGGTGATGCTCCTGACATGGTGGTGCTCCTGACATGATGGTAAGCCTGACATGGTGGTGCTCCTGACATGGTGGTGCTCCTGACATGGTGATGCTCCTGACATGGTGGTGCTCCTGACATGGTGGTAAGCCTGACATGGTGGTAAGCCTGACATGGTGGTGCTCCTGACATGGTGGTGCTCCCTGCACTGACAGTTCTGAGGAGGTGGAGATAGGAGGATCCACACTTGGAAGCTTGCCTGAGATACACCCTGTCTCAGAATAGGCTCGAGGCTGCCTCTGCCCTTTTGCTTCTATCTCTTTTTCCATATGTGTGTGTGCGTGTGTGCATATGTGTATGCATATTTGTAAGTATATGTATATAAATAAACACACACACACACAAACTTACTCTGTATACTAGGCTGGCCTTGAACTCAGAGACCTGCCTGTTTCTGCCTTCCCAGTGCTGGGATTAAAAGCGTGTGCCATGGGCTGGTGAGATGGCTCAGTGGGTAAGAGTACCTGACTGCTCTTCCAAAGGTCCAGTGTTCAAGTCCCAGCAACCACATGGTGGCTCACAACCATCCGTAACAAGATCTGACGCCCTCTTCTGGTGTGTCTGAAGACAGCTACAGTGTACTTAAATAAATAAATCTTAAAAAAAAAAAAAAAAAAAAAAAAAGGCGTGCACCACCACTGCCCGGCTAGTTAGCTTTATCTTCCGTGGATGTTTTGTCTGCAGTATGTCTGAGTGAGGGTGTCAGATCCTCTGTAACTGGAGTTATAGACAGTTGTGAGCAGCCATGTAAGTGCTGGGAATTGAATCCGGGTTCTCTGGAAGAGCAGTTCATGCTCTTAAGCACTGCGCCATCTCTCCAGCTGTCCTTATTTATTTTTAAGGGTCTCTTGTAGCCATACAGGCCAGAAACCCACCATTAGCCACGGACCTTGAGCTCCAAGTGCTGGGTGACAGGCCCGCATCTCTCCTGGTTTGTGATCTGCTAGGGATGGGGTCTAGGACCTCACACAGGCTGCATAAGCATTCCCCTCACCCACCCTCATCCCCACCCAGTCCTGGACAGGCTCTGGCTGTGTAGGCTGGTCTCCTCCTTTCTATCCCCCTGCCTCAGCCTCCTGAGTGCTGAGGNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNCTGTGGTGGCTCCCGAGTGCTGTCATCCCAGCACTGGGGAGGTTGAAGCAGGAAGGAGAATCACAGGTTCAAGGCCAGCTTGGTTTACTTGAGACTCTGTCTCAAAAAGACCAAACCAGGGACTGGGAGGATGGCCAGTAAAATGCTTTTCCAGCTATCGAGGGAACCTGAGTTTCATCCTGGAACTCATACAAAAAGCTGGCTGTGGTCAGGTGGCGCATGCCTTTAATCCCATCACTCAGGAGACAGAGGCAGGCAGATTCTTGAGTTCGAGGCCAGCCTGGTCTACAGACTGAGTTCCAGGATAGCCAGGTCTACACAGAGAAACCCTATCTTGGAAAACAAAACAAACAAAAAAAACTAGGTCTGGCTAGCCTGTAACCCCAGTGCTGGGTAAACAGGGGCAGGTGAATACATCTCCGGGATTCGCCAGCCTGTCCTATCTATGAGCTCTAGGTCTGGGGAGACAGCCTGTCAAATCAATGCAAGCAGGTGACAACCGAGGAAAGACACCCAAGGTTGATGCACGGGCAAGTGTGCACACACACACACCACAGCAAACAAAAACTAACAAAACCCAAACCATATTTTGCTGTGGTGGTGGTTGTTAAATTTTATTTATTCTGTGTGTATGGGTATTTCACCTGCATGAATATCTACCTGTGTAGCATATACATGCCGGGTACTTTCGGAGGTCAGAAGAGGACATCAAATCCCGTAGAACTGGAGTTACAGAAAATGAACTTGTGGCTTCTGGGAATCTAACTTGGATCCTCTAAACGACAGGCAGGACTCTGAATTCTTGAGCCACAGATACAGCTTTCCAAACCCATGTTTTGTAACAGCCACCAGGCCTGAAAACTCTGGGCCATGTCCCGTTTGTTGTGTCTAGGCCTCAGTTTCCTGGAAGGCAGAGAATGCGTAGGTCCGTTGTTAGTGGAGACAGCAGTGGTCGTAACAGCCTGGTCTACCCTCTTGGTCAGAGGGAGGCAGGCGGAGAGTAACTCAGGGCCTGGGGGCAACACCCAGCTGGGCCTGGGGCTAGTGGGGGCTCAGCCAGGCAGGACGTGGGTCCTCCTACTTCCTAAGCTCTGATGGGCAAGTGGTGCCAGTGGTACCAGGCTGCCCTGAGGGGCCCTTAGAGCAGGTGACCACAGAGCCACAAAGAGGCTATTCATGGCCTCCGGTTCACGAGGCTGCCCCTTTATTGAGGGCTTGAACCACAGAAAGCTGTGTGGTCTGCAGGGAAGCTAGTTCTGAGCTGTCTGGCCAGCTACAGTAGTCTGTGTGTGTGTGTGTGTGTGTATACACATGGTACTTTTTTCTATCTATCTATCTATCTATCTATCTATCTATCTATCTATCTATCTATCTATCTTTGTGTCTATGTATCTAATAATAAATTGATCTATTTAACTATGTAGATATCAATCCATTGATCTATGTATCTATCAACTCATGTCTATCTATGTATGGATGTACCTACATCCGTACTTGAGGCACGACTTAAAGTACCCCAGGCTAGCCTTACCACATTTCATAGCACAGGATGGTCTTGAACTTCAGGTCCTCCTGTCTCTACCTCGTCACTGCTCCGATTACAGGTTTGTGCCACCACGCCTGGCTTACCAGCTTCTGTGGTTAGGTTCCAGGATTTCACTATCAACTGCGCCACATCGTCAGCCATATTCAATATCCTTTCTTTTACATTCTTACTTATTTACTACAAATCGGTCCCAGGAACCAAGGTCGCCAAGCCTGATCGTCAGTGCTCTTCCCTGCTCCCTGACTTATTTGCTCTTTTTTTTTTTTTTTTTTTTTTCTAGACAGGGTTTCTCTCTGTAGCCCTGGCTGTCCTGGAACTCACTTTGTAGACCAGGCTGGCCTCGAACTCAGAAATCTGCCTGCCTCTGTCCCCAACCCCACCCCCAGTACTGGGATTAAAGGCATGCGCCACACGCCCAGCTCTTATTTGCTCCTTTGAATTAAGGTCTCATGTACACAAGGCTGACCGTTCATGCACAATACAGCTAAGCCTTCCTTTGAATTTCTCAGTTTCTTTCTTCTACCCAACAGTTTCTGAGATTTCAGGTCCGTCCTATGTCATCCCCAGGTTTTTTGTTTGTTTCTTTGTTTGTTTTTTGGTTTTGTTTTGCTGTTTTTCAACACAGAGTTTCTCTGTGGAACCCTGGCTATCCTGGAACTCTGTATACCAGGCTGTCCTTGAACTCACAGACCCTCTCCCTCCCTAGTGCTGCGTTAAAGGTCCCTGCCATCACCGTGAAACTTAAGCCCACCTTCTCATTTGGTGGCTGGAAATTTGCCTGCCTCTGCCTCTCTCCAGCTGCCTAGCACTGATCTCTGGTTGAGAGCAGGGGAAACTGAGGTGCCGCTAGGACAAGATCTCATGCAACCGTGAACAGCCCTACTGAGCCATCCTCCTGGGACAGCCTCTCAGGCCAGGCCTTCTGTGTCTTCTGCTATAGTAGCAGTACAAAGTTGACACAACCTTGCTCTTCCCAGCAGCTGGGAGTTCCTGAGAAGTGTAAATGAGGTTTCCAGGAAAGCCAAGAGGTGAGAGACTGAAAAGTTGGAGGGATAAGGGGGTGCCCATCAAGCTGCAGTGGAGACTTGTTATCTCTTCCGCATCCCTGACATCTCAGCAGGAGGATCAGCAGTTCAAGGGCATCCTCAGCAACATAGTAAGTCTATGGAGCTAGCCTGGGCTACACAGATGCCATTACAAAAAAAAAAAAAAAAGTAAAAAAAAAATCTTGGGATATGGGGGATGGGTGGGTGAACTGTGTAGCCCAGGCACTCACTACTGGTTCCTTTGGAAGTCCCTCTTCTGCATCGAGATCATGGAGATTCTGGGGACACTCCAGGACTCCTCCTTCAGGGAACTAAGTTGGGGAGCACCGCAGCCTATCCTGTGGCCTTATTTCCTGTCTGCTCCAAGCGCCAGGCAAGGCATCCAGCCAGGAGCCACTCAGGCCTGACCTCCGCTAACTGTTCTGTTTTGTGCTGCACCCTCATCTCAGCAGGGATCAGGTGCCACTTGGGTCCCCAGGGGATCCAGGGACACAGTGTCCATGTCCCCATCTTTCCCCACAGGCACCTGGGGCAGGGCCGAAGAGGAGACCTCGTGATGTGTACAGGTCTAGCTCATCCCTCCGAGGACTCAGGGGACACTTGGGGAAGGTGTGACACAGAGCAGCCTGGAGCTCTGTGCGGCTCTTTATTAAGTGTGCCTACAACAGGGGCAGAGACACAGCAGCGACAATGATAACAGCCCACTCCCAACCGAAGCTCAATGGTTACCAGACTCAGCCAACTGCAGAATTCCAGTCCATAACGGCACCTCCTTTCCTTTCTCAGGAGCTTACCAGAGAGGTCTCACCCCAAGCCTTCACCCCATCTAGAGCAAATGCTTATATCCCCCATGTTTGCTCAGAGCAGAGCATGCACCGACCTTCCTGTCACCAGAGGCAGAGGCATTCTGTATACGTGCATACACGCCTCTGTGTGTGTGTGTGTGTGTCTGTGTGTGTATTTGGTACAGATCTAAGCATAGAAAATTGAAAAGCATTGAGGTTGGTGATTGAAAGCCTCACTGATGGGCAAGTCGGGTTCGAGTGCGCTAACTGTATGACTCTATGGATCCGAATATCATGCTGTTTTGGAAAGGAATGAGGGAGCTACTGTTTCTAAGGAAGAGAAGAATGGGCACCAAGACATAGGGAGGGAAGGTGGGACAGTAAGCACTTACAGCCGAAGCCCAAGACCTGGAACCCAAGGGGAAAAACAGGTGTCGCCAGGCTTGGTGGCACGCGCCTTTAGTCTCTGAGTTCAAGTCCAGCCAGGATTACATAGCAAAACTTTCCCTCAAGAAAAAAGGTAGGGGCTGGAGAGATGGCTCAGCAGTTAAGAGCTCTTCCGAAGGTCCTGAGTTCAAATCCCAGCAACCACATGGTGGCTCACAACCATCTGTAATGAGATCTGACGCCCTCTTCTGCTGTGTCTGGAGACAGCTACAGTGTACTTACATATAATAAATAAATAAATCCTAAAAAAAAAAAAAAAAGAAAAAGAAAAAGAAAAAAGGTAGAGGAGGAGGAAGAGGAGGAGGAGACGGCAAGACAAAACTAACTACATAGCTGGGGGAGGTGGTGCTTGCCTATAATCCCAGCACTTGGAAGGCTGAAAGAGGAAATCAGGAGTTCCTATGCAGCTTTGGCTTATGTGAGCCTTTCTCATAAAACCAAGAGCAAAAAAGCAAAACATGAGGTGGTAACTCAGCTGGAGAGTGCTTGTCTAGATTCCCTCAGTGAGGGGCTGGGGTGTGACTCAGTGCCTAGAATCCCCCAGGGAGGGGCTGGGGGCGTGGCTCAGTGGTAGAGCCCCTGGCTAGAATCCCCCATTGACGGGCTGGGGTGTGGCTCAGTAACAGACTGCTCACCTAAGATGTTCAAGGCCATGACTTTCATTGAAAACATCACAAAACAAACAAAACCATCAGTGAGGTTGAATGTGTATCCATGTTTGCTTGTCTCCATTTAAAGAACACCTGGAAGATCTCTAGCTGCTGGTGGAGGCGGCAGGGTGAAGGCTGCTTCATCCTTTGTATTTGAACTGTGTGGCTGTGGGTGTATTATCTGTTCCCAAGGACTGCACATGAAATGAGAACAATGAAGGCTTCGGTTCTGCTGAGATGAACCTCAATTCTCCACAGATGATCTCACCCAGAGCCAGATGGAAGTCCCCCAACATTTAAGCCTCTGTTCTGAGTGCTGGACCCAAACTCATCTTAAGGGAAAACCCAAAGAGCCTTTCTGTGGTTTCCTTCCACAACTGTCTTTCAATGTGTGTATGTGTGCACGTGTGTTTGCTTGTGTCTGTGTGTGTGTACTATGTGCATGTGTGTGAGCATGTGTGTATATGTATGTGCATGAGTGTGTGTGTGTGTGTGTATACATGTGAGCATGTATGTATAGGCCAGAGGTTAGTCATGGGTAACTTTCTCCACAGCTCTCCACCTTACTTTTATTGTCTGTGTGTGAGCCGCTGTGGGCACTGTACACCACAGCACATGTGTGCAAATCAGAGAACAACTTGTGGCTGTCACTTCTCTCCCTCTGTCTGGGTCTAAGACCTGGATCCACCGCTTTCGCTTGCTTGAGACATCTCGTTGACTAGCTCCTCCGTTGTTAACACAGGGTCTCACTATGTAGGTCCAGTTATCTTGGAATTTGCTCTGTAGACCAGGCCGGCATCAAACTCAGAGATAGACCTGCCTTTGCCTCCAGAGTACTGGGATTAAAGGTGTGCACCACTACCACCCAGTTTAAAATTCTAAAAAGATTTGTGGGTGCAGGGATTTGAGGAGGCCAGGAGAGACTGTTGGATCTCTGGGAACTGGAGTTAGAGGTGGTTGTGAGCCCCCACGGGTGCTGAGAACTGAACTAGGGTGCTTGAGAGGAGCTCACTCACTGCTGAGCCCCCACTTTAGATTTGACTCCCTCGTACTGAAGCTGAGTTCAGTGATTTCGCTGAGCTGACCGCTCAGGGTGGGCTTTTCGATGTGCACCACAGGCCTGGCTTTATAGGTGAGGTCATGCTTGCACAACTGGCCTTTTGGTGACTCAGCCAACTCCCCAGACCTTTTTTCTTTTGCATTTACGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTCTGTGTGTGTACATGAAGTGAGAGGGGGCAGTCTGGGAAGGGTCAGTGGACAACTTAAGGGAGTTGGTTTTGCCTTCCATCATGATGGTCTAGAGACTAAATTCAGCCCCTCAGCCTGGCAGCGTCCCTTTACCCTCCGAGCTCCCAGCTTTGGGTTTTTGAGGCAAGGTTTCATATAGCTTAGGCTGGCCTGGCATTCAAGGTCATCTCAGAGGCCTAGGATGACCTTGTGTTGTCGGTTCTCCGCCCTTTACCTCTGGTGTGCTGGCGTTTGCCTTACCACACCCAGGCATCCCCCATAGCTTAAGCCTAAAGCTCTCGGATCGCCAGCACGCCCATGCCCTGACGTGAAGTTCAGTGACTAATCAATACAGAGCGTTCACGGAGCCCTGACACATAGCAGCATTGACTTAACCTTAACAGCCTGGTGTGTAATGAGGCCAACTTGTCCCATTCTGCCCACGATGCGATGCTCTGGGTTAAACAGGTTTGAACACAGTACCGGATGGCAGGGACGGCACCCTCAGTACAGGGTTTTGGCTGTTACTGCTTCCAGTCTCCTGACCTGCTCCCCCAAGGCTGGTCTTAAACTCAAAGCAATCCTCCTGTCCCTGCTTCTCAAGTTCTGGAATTACAAGTGTGACTCACTGTACCCAGGAATATGTGTCTTTATTACAGAGGAAGCACACCTCAGAGACTGAGAGTAACCTGTGCAAAGTCCCACAGCAGGAGAGGGTGGCTGGCTATCGGCCGTGAACTTCCTGACCTTTCCTGTGACCTCTAAGGGAGGAACTAGATGTCCCAGCAAGGATTCTAGGGACTTGTCAGGACTCACCTTTGATGATGGGAAAGCCATCCCATCTCCCCTTCCCCTTTGATGGTCGCTCCAGGGGTTTGCCTGGGACAGAGATGTGTTTCCACACAGATCACCCTGAAGACTGGTCAGTTTCAGTACCCTGCCCAGCCTGTGGCTGGGAAGGGCCAGGGGCCCAGATCTTGTGGGCAGCCTGGGGTAGGGCCAGCATTCCAGGGGCCTGCCTGGCATGTGGGGAATGTCCCAGGAGAAGTCTCAGTCCTCCAGAAACTCAAAGGGAAGTGTTCTTACGTGGGGTGGTGTGTGGTGGGAGGTGGGAGGTGGTGTTTGTGGGAATGTCCCTCTGGTCTGGAACCCTGAGGGGCTGCAGTTACCAGGTACATTGGGCCTGTGCCATTCTAGGCACCTGACCTGCTTTTCTGATGTCTTCATAAACAGAGACCACTATTCCTGCCTTACCTACCCTGCTTCCTGGTAGACCAGCACCCCGGGGCTTCAGCATCACCACAGTAGGGACTTTTGTGGGCCACTGACTTGGCCCACAGTTACCACAATTTATTTAGAGTCAGCAACGTGGCTGTACTCTATGCTGACCCGGGAATACAAATCTCGGTTTCTGCTCAGGAGGCCCAGGCTACAAGGCCTTGAAAAACCCTGAGGCGGGCGGGGCAGGTACGGCTCTGCATGCGCCTCTCTAGAAATTAACCTCCTTTCTACCCCAGACCCTTCTCGCGTCTCTGGCTTCTTCAAGGACCGGCTCTAAGGCTACTTCCTGCTACACCCTGGACCCTCCCTCCATCCTGAAGGGATCATTATCTTAAACCTGGTCCTTCCCATCGACTGGGTTTGGGGGTAGGCGTGTTTCAGGATGCCCTCAGAGACCAGGAGAAAGTTGGAGATCACCCAACTACTGCAGAGCACGACTGTGGAGGAACAGTTAAATGGACTAGCAAACACGAACGGGCCAGAGGCAGAAGGACTGCTATGAGTTCCAGTCCAGCCTGAGCCACACAGATACTTCAAGCCTAGTCTGAGTTACAGAGTGAGACCCGGTCTTAAACCCCAGAAAAACACTCCGGGGAAGCGCAGGGGACCGGGCGCGCGCTGCAGAGCCCCCTCCCCGGCAGGCCCGGGTAGGGGCGTGGCCACGGTGACGTCATCCTCCTATAAAACCCTGGGCGCCGCCGGGCTGGCTTTGTGGAGAACTGCAGCCGGCTAAGCCGTGTTGAACAAAGGACGTCGGGCACACCTATCCAAGCTCCCGCGGCCACCCGGCCGCCCTCCCCCACCATGACCGCCAACCGCACCGCAGAGGCTGTGCAGATTCAGTTCGGGCTCATCACCTGCGGCAACAAGTACCTGACAGCCGAGGCGTTCGGGTTCAAGGTGAACGCATCCGCTAGTAGCTTGAAAAAGAAGCAGATCTGGACGCTGGAGCAACCTCCCGATGAGGCGGGCAGCGCGGCCGTGTGTCTGCGCAGCCACCTGGGTCGCTACCTGGCCGCCGACAAGGACGGCAACGTGACCTGCGAGCGCGAGGTGCCCGACGGCGACTGCCGCTTTCTCGTCGTGGCGCACGACGACGGCCGCTGGTCGCTGCAGTCCGAGGCTCACCGGCGCTACTTTGGCGGCACCGAGGACCGCCTGTCCTCCTTCGCGCAGACCGTGTCGCCGCCCGAGAAGTGGAGCGTGCACATCGCCATCCACCCGCACCTTAACATCTACAGCGTTACCCGCAAGCGCTACCCCCATCTGACCGCGCGGCCGGCCCACCAGATCGCGGTAGACCGCGACGTGCCTTCCGGCGTCGACTCGCTCATCACCTTCGCCTTCCAGGACCAACGCTACAGTGTGCAGACGTCCGACCACCCCTTCCTGCGCCACGACCGGCGCCTTGTCGCACCCCCGGACCCCGCCACGGGCTTCACGCTGGAGTTCCGCTCCGGCAAGGTGGCCTTTCGCGACTGCGAAGGTCGCTACCTGGCTCCGTCCGGGCCCAGCGGCACCCTCAAGGCTGGCAAGGCCACCAAGGTGGGCAAAGATGAGCTCTTCGCCCTGGAACAGAGCTGCGCTCAGGTGGTGCTGCAGGCGGCCAACGAGAGGAACGTCTCCACGCGCGAGGGTGAGTTGGGGACATGTCCCCTCCCTTGCGTCCTGACCCAGTGCACAAAAGCATCTCTGCACTCCTTCTATTTCCCTATTTCCTCCTCGGCTCCCTTTAGGCTCACAGGCCTCTGGGCTCCGCCATGGGGAGGTGGGCTTCTATTTTGAAAGACCTGATCTCACCAGATAGCCTTGGCTATCCTCGAACTCGCTATGTACACTGGGCTGGCCCCGAACTCGCAGAAATCTTCCTTCCTGTCTCTTCTGCTGGGAATAAACCCATGTACCACCCCTCTGTTCAGGACGTAGGCTTCTTCTCCTGGGAGAAGGTGACGTGGGGAAGTGGGTAAGGCCTAACACATTCTAAAGCAATACTGTCCACCACCACCCCCCCACCCCCCCACCCCCCCGGCTGGGGGCGTGGGACTCCATAGACCTAGCTTAGATCTTCTCCGTTTCCTCTTCCTTCCCAGTCTGAGCCATCCCCATTCATGAGCCGATTCTTTAGGATAGGCTGTCCCAGGTCTTGGAGAGGAAGGGTTCCCCCTACACCCCCCCTTGTTCATTTCCTCCTGCGTCCTCTCCCGTTTCGCGGGCCTTTGGCTCGAGGGCCAGGGGACAGTCACCCCTGCCCTCCCCGCCTTAAATGGCCAGATAGAGGAGGTTCGAGCGGCTTTTGATCCCGGCGGGGTGTGCTGGGCCGGCTCGGCCCTGCGACTCTTGGTGCTGGTGGGGTTGTCCCTAGGGGCTTCCCCTCCCCCACTCCATCTCCCCTCGCTAAGGCCTGGCGCTCCGGGCCGCGGCCTTTGTGAGCAGGGGCGCGGGTCGCCACGGCTGGGCCCTCCCTCGTCCCCTTTGTCCTGCTAAGGCTCTGCACATCGCAAAACCAGATGCGGCGGACCTGGGGCAGGGGATCGGCTTACGCGGGTCCCTCTGCGGAAGACCCACCCCCAACCCTCCAGGCGTTGTCCCTGGTCCAGGGTTCATTGAGAAGGCGCGGAGTGAAGCCGCCTGGCTCTTCCTTCGCACCCCGGCTGGCAGGCGGCGTGGCGCCGGTGGCTGCGCGCCAGGCGCCCTCCCTGCCCTCCTATGCACGCCTTGCGGTCCGGCACTCGGCGGACTGTCCCTCCAAAAGCCTCTACTCTCGAGTGAACCGGTCCCCAAGGCCTCTCTGGCTGGGAACAACCGTTTGCACCTCTATTTGTCCCCATCCAGGGCCTCCAGCACCCTGGCAGGCCATTTCCGACCGGCATGGGCATGGTACAAGTAGGCGCCTCCTTTCTGGCGTACCCCCCACTCTTCAAAGGGTCTTTGCTCCCTGCTGGTAGGGGCTTGTGAGATCTCGCTTCCTTGGTTGGGAAACTGAACCCCAGGCTTTGGAGATAGCTGGATGGGAGCCAGTCTGTGGGGAGGAAGACCCCCCTCCCCCAATGCAGAGGGCAAAGCCTTGGGTGGGGCCTGCTTGAGTTTGGCTGAATAACGCTCAGAAAAGTGCGACCATTTGCTTACTGTTACACAGTAAGTCAGCACCATGCTGAACTGGGTGTACTTGATGCCAGAATGTTCTCTCATTATACACACACACACACACACACACACACACACACACACACACCAATGAACCATGGCCTCTCTTGTTTCACAGTGCTGGGCGAGGGGGTCAGAGTTCCCACCTGTTTAGCAAACATTGAGATACGAGCTGCGGTAAACGTCTCTTGGGAATGTGACTGGTATGTAAAGCAGAAGATTGGGGGTACAGGATCGGGGTAGTAGATTATAAAGATCTGGGGTCCCTTCTGAGGACCCAGGAGCTGCCCCAGGAGAGTGAATAGAAATGAGCATGCACCAAGTTTATGGACTGGTTTTGCAGGCAGGGGCCTCAGCAAAGCCCCGGAGGCAGGGAGTTGCAAATAGAGAAGCCCTGCATAGCTAGGAGGAAGGCTCGGATTGCACGGAATCCTGCAGATCACGGGTACTCCAGAGCCTAGAGAGACCAGCTCTCTGCTTACACAGCTGTGGCCGAGGCTTGTGCCCTGGGGAAGGTTAGGCAAGGCACAGGTGACTTGGGCCCTTGGGGCCTGAAACGAGCTAGAGGGTGTGTTTTGCGAGCCTGCACAGGTACCCTTTTCTGAGGGTGCCATGATTGTGCATGATTCACACTGATGCGGCAGGAGGGGGCGGCAATTGAAGGGGTGAGAATCTGACGGGAACTTGGGGTCACACACAGTCACACCTCTTCTGCCCTCCTATGTCTGCGTCCAAGTCTCATTCCCGAGTCAGCCAACTCCTCCCCCGGCTTTTTGAGGGTCAGCTGTTGGGTGGGTGTGCCGGCGAGGCCATTTTGGGCAGGCTTGCGTGGCAGGGAGGCGGGGCTGGGCTTCGGGGAAACACGTGTTGAACTGCTACCCAGGAGTAGGGACAGGGAAGGCTCAATCTGGTCTGGGGTTGTGAATCTTCCATGCAGATTTGCTGCTTCCGGCTTCCTGGCCTCAGTTTCCCCATCTGAAAGCACAGAGGTACATTGAGCCAGGATCTTCCTGGGAGGTGGAGATCCTATGAGAGTAGGATGGGGGGTAGTGGGTAGGGTCTTTTCCTCCTTGCTTCTCATGACCCTCCCAAGCCCCTGCTGGCTCAAGGACACCCCGTGCTATGTCTCCCCACACTGCCCACCCTGCCTTACTTGTTGGGTTCTAATGCTTTCAAAGAATTTTGTCCCCATCATTTCTAGGGCGGCTGGCTAAGAATGAGTCACAGGTGAGGCTGGGCTTTGTACCGTATCCTTTTGACGGCTTCCCTCTTGGGTCGAGGAATGGCTTAGTTTTGAGCACTGTACCACTTTGGGCGGTGAAGTCCTGGAGGGTTCTAAACTAACCCGCCTTCTGGGTTGTGAGGATTGCTTATTTCGAACAACAACGCTAGGCACTCTGGCAAACAGCTAAGCCCAGGAAGGGGGTTGCGGGTTAGAGGACCCTCTGAGTCACCGCAGAGACGCCTAGGAAGCTGGAAGACAGCCACGCCCCCTCCGTGCGCTCCTAGGAGCCAGTGACTCAGGTTTTCTGTGCTGCTCCTGCTGAAAAAAAAAAAAATCCCACAGAAAACCTGTTACCATAGCAACGCAGCTCCAATATGATTCCAAGGCCAAGTGGGGCCTTTCCCCCTGGCTGAGCCTTAGAGGGCCCATTCTGGAAGGGGGCTAACTTCCCTTTCCGGCTGAGGTGGCAGGGCCCACCATCTCCTTGGCAACAGGCCCTCACGTCCTTTCACGGTCCCAACAGAATTGAGAGGCGATTCTTTTTGGCAAGGGAGGGAAACTGAGCCAGAGAGCGGAGAAGACATTCCCCGAACGGTGCCTGGAGTCCACCTTTGGTCCCTTGGTGGCCTCTTTATTAAAAAGTGGTTGCACAGGCCCCTTTGTTCCAGTACCTGGACATGAGACCCACATGGTCAGGCCCTTTTTGTTCTCTGTCTCGACGTCTCATTTTTCAGAGCTACTGGGAGGTTGAAGGTTGGTCTATGTCCACAGCACTGTGCTGTCTTGACTCAGTGCGCATGACATCTTGGGCCAGGGCCTCTCCTTTGTGTGAGGCAAAGCTAGCATGCTGGGAAACTCCCACTCCTTTAGTCCACCCACTTTAGTTGTACTTTTTGTCTTGTAGCCCATCTGCCTTCCAACTCTCCATCCTCCTGCCTCAGTCTCCAGGGTGCGGCGATGACACGCATAGGTCACCACAGGCTTCTCGCCTCCACTTGATGGTTGCCGGAGTGGCTGGGAGTGGCTTTTCTTTTCTTTTCTTTTCTTTTCTTTACTTTCAGGCAGGGTTTATCTGTGTAGTCCGGCTGTTCTGGAACTATGTNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN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TATCCCTCTCTGCTGAGCCATTCCCTGACTGGCCCATCTTTGTTGCTGTGAAGCTCACTCCCTCCCTTTCCCTGTGGCAGGGGACTCGGAACTCTTCCTCATGAAGCTGATTAACCGCCCCATCATCGTGTTCCGGGGGGAACACGGGTTCATTGGCTGCCGCAAGGTCACGGGCACTCTCCATGCCAACCGTTCCAGTTACGATGTCTTCCAGTTCGAATTCAATGACGGCGCCTACAACATCAAAGGTGGGTTCACTGGGTGAGGATGCACCTGGCCATTCAAAGCCGACATTAGGGAACGGGTGTCCTATGACCGCCTGGGGTAGCCCCTCCCCCCTTGTCTTAGAACTTTCCTGGCCCAACCTGGGCAGACAGCGAAGGTGGGAAGCAGCTAGGGAGAGTGGTCGTGGCTCCAATCTGGGAATCGCACACAGGAGAATTATCTTTTTTTTTTTTTTGGTGTTGAGGACAGAACCCAGGGCTTTGAGCTTATTAGGCAAGCATTCTACTGCTGAGTTAAATCCCCAACCCCAAGAATCATCTCAAAAAGAAAGAAAGAAAAGGGAAAAAGAAGGTCGAGCCTGGTGGTGGTGGTGGCGGCGGCCGCGGCACACGCCTTTAGTCCCAGCACTCAAGAGGCAGAGGCAGGTGGGTCTCTGAGTTCTTGCCAGCCTGCTCTACAGAATACATTCTAAGACAGCCAGAGCTATGCAGAGAAACCCTGTCTCAAAAACAAACAAAAAAAGGGGGTGGGGAGAGAAGATAGAAGATAAGGATATTCCTTCTTAGCTAGCTGTGGGACCAAAACCAGTGAGAGGACACAGCAATCCAGAGGTGTCAGTCAGAATCAGAGCCCTGTGCTGTGTGTGGCCTTAGCAAGGCAAACGGGACTCCTTTCTTACAGTGCTGAGGACTGGACTCAGAGCTAAGATCCAGCCCCTCCCTGCCGGATTCTAGGCAGCGGCTCTACCACTGACCCACGCCCCCAGCCCCTCACTGGCGGATTCTAGGCAGGTGTTCTACCACTGAGCCACGCCCCCAGCCCCTCACTCGGGGATTCTAGGCAGGGGCTCTACCACTGAGCCACACCCCCACCCCCTCACTGGGGGATTCTAGGCAGCGGCTCTGCTGCTGATATATGTCCTTTTTGTTTGTTTACTTGTTTGTTTGTTTGTCTTATTGTGGCCCTAGCTGTCCTAGAACTTGCTTTGTAGACCAGAGATATACCTGTCTCTGCCTCCCAAATGTTGGATTTAAAGGCATGTGCCACCATGCCCCACCCTAGCCTACCCCTCTTATGTTTTGTAGTTTGAGATGGCATGTCAGTAGATTTCCCAGGATCGCCTTGAATCTAGGTAATCCTCCTGCCTCAGTTTCTTGAGTATTTGAATTATGCGACTGTACCTTACATCCAGCTGAGCCCACTCAGTTCTGGAAGCTCACAGCGGGAGGGAGTGTTAATCCTTTGGGGACTGACAAGGTGGGGTTAACATGTAGTCTCCCTCCTCAGACTCCACGGGCAAGTACTGGACGGTCGGTAGTGATTCCTCGGTCACCAGCACCAGCCACACCCCTGTGGATTTCTTCCTTGAGTTCTGTGACTACAATAAGGTGGCTCTCAAGGTGGGCGCCCGCTACCTGAAGGGCGACCACGCTGGCGTCCTGAAGGCCTGCGCGGAGACTATCGACCCCGCCTCACTCTGCCAGTACTAGGGCCACCTGCCCTCTGCACGCCGCTCTCGTCAGTCCCTCCTGTTATCCTTACTCATCGGGTGGCCCTGCAGCACGTGGCAAACCCCTTGCCTTTCAAACTGGAAACCCAAGAGAAAACGGTGCCCTTGCTGTCACCCTCTGTGGACCCCTTTTCCCTAACTCACTGCTCCCCATGGGTCGGTGGCTGCAGACTGTCCCCAGGAGGGACTCTGGTTCCCTCTGTCCCCTTCTTTCCATGGGGAACTCTGGCACCTTTCTTCTCACCTCAGTCAACTCTGACCCTTATTTCCCCCCAGGAAGTGGCCTAGGAGAAGCTACAGGGCCTAGGGACTTACCCTGAGCTTGTAACTGGAAGACCCCGTCCCTATCCCCGCTCCCGCCCCCACCCCACCCCACCCCTGCTCTGCCCCCAGCCTCTGGAGGCCAGCCTTTTGGCGGGACTGAAGCCCGCCATGGCCAACCTTGCCCACAAGTCTTTTTCTGGATCTTGGCTGGAAGGCACTCTGTCCCATCCTGCAGTGTTTGGGCCTGGCTCTTTGACTCAAAGCTAGCTACGTGGCACTCCGTGTCGCTCCTGCACATTCTGGAAGGGGCGGGCCTCTCACCCACCTCATTCCTTTTCCCCCTGGCCTGACTGGAAGCAGAAAAATGACCAAATCAGTATTTTTTTTTTTTTTCTTTAAGGAAATGTTACTGTTGAAAGGCCCTAGGCAAGCCTGCCCTGTTGGTTGTAGTCGTGAGTGGTCTTGGGGGCACATGCTTGGCTCCTGTCCCTCCCTCCCCAGCGGGTTCCCTCCCTCCCTCCTGCCTGACCACCCCAGCTCTGGCTCTGTGATTGGTGCTCCACGTCTTCCCAGACACCTCGGGGCTCCTGGGCGCGAGAAAGCCGGATGTGCCCCTCCCTCGCAGCCCTCGACTAAACCTCACGGCGCCCTTTCCCAATCACCCCCTTCCACCGACCCCTCAACACCATCCATCTCACTCTGGGTGTCTCGCTCCTTTATTTTTTTGTAACTCTCATTTCTATAACTCTGAAGACCCATGATAGTAAGCTTTGAACTGGAAAATAAAGTAAAATCAAGTCTGCGGCCCGTGTGTGTCTCAGGGGAAGTGGATGCTGGAGTGGGCAGAGGGCCGGCTGGGAGGGAGGCAGCGCTGATTGATTCCCAGCCCGCAGACTCTTGTTTCGGTCTCGGACCCTAGCCGCTTCAGCATATCCCTTAGTAACTCTGGACTGAGAAATGGCTGACACGAGGTTCCCCAGCCTTACAAGCTGGGCAGGCTACAGCGTTCAGCAGGTAAAGTTGTGTGCTCTCAAGCTTGATCAGACTCAGTCCCCACCACCGTGTGAAAAGTTGGGCACAACGCTGTACACCCACCCCACCCCCTCTGGCAAGCACAGAGACAAGAGGATCCTTGGAGCCTCCTGGCGGCCCAACCTTGCCCAATCTGTGATTCCCATTGACTGAGCCATAAGGTGGAGATGGGTTTTGGAAGATACCCCACATAGGCCTGCGGCCCCCCACACCCGGAAATAAAAACAACCCAGCCTTGTCATCCCAGTTATTCGGGGAGCTGAGGCAGGACGATCACAGATTTAAGACTCCCCACGTTGAAGAGTAAGTTCAAGGGCAGCCTCCACATCTTGCTACATTCTTTTTTTGTTGGTTGGTTCCTTTTTGTTTTGTTCTTTTTTTCGAGACAGGCTTTCTCTGTGTAGCCCTGGCTGTCCTGGAACTCACTCTGTTGACCAGGCTGCCCTCGAACTCAGAAATCCGCCTGCCTTTGCCTCCCGAGTGCTACCATTAAAGGTGTGCGCCACCATGCCACGCTTAGATGTTTTAAATGAACGGCTCTGGAGTGTGGTTCACGGGTAGCCTCCCTCAGACAGGCTGGCGCAGGACAAATGGATCGCTCAGCATTGGCTCCTGCCTTAGGGTTTCCATTCCTGTGAACAGACACCATGACCTGGCAGCTCTTCTGAAGGACATTGGACTGGGGCTGGCTTACAGGTTCATCAAGGCAGGAAGCAAAGCACAGGCATGGTGCAGGAGGGGCTCAAGTCTACGACCCGGGTCTCAAAGCCCACCCCCACAGTGACAGACTTTCTCCAACAAGGCCACACCCACTCCATCAAGGCCACACCTCCTAGTAGTGCCACTCCTTGAGCCAAGCTTATTCAAACCACCAATCACAACTGCTTTTCTAGAGCACCCAGCTTCAATTCCCACCATCCACATGACAGCTTACAATTGTAACTACAATTCCAGGGGATCCAACACCCTTACACAGGCACACTTACAGGAAAAGCACCAATCAGTGCACATAAAAATACATAAATCGTTAGAGAGAAGAGACCATTAGCTACCTTCACCCTTAACAGGCAAGCTGAGGTCCTGGGAGTGTCTTAGAGGTCCGCAGCTTGCAGTCTATAGGGTAGTGGCATCGTCTATACCTTCCTTCCTTGACAGGTAGGTACTTAGCTGAGACCTCTGGGGTATCCCAGAGACCCATTTTACAGAGCGAGGCACTGAGGCGGAGGGAAAAGACAACCTTGTTTGCTGGCTCACAACAGTGCCAGTGGGGTACCCACCCACAAGGCTCAGCATCCCGAGGCACTGTGGAGGCAGTTACAAAGCCGCATTGATTGGCTGCTGATGACGAAATGAAGAGCCCCGCGGTGTGATTGGCGGTCCCACACGGAAGCCATGTGGGGAGATTCACACGGGCAGATGGCCACAAAGGGTCCAGTGACTTCCCGCAGGGTGGAAGCTCTGGGCCCAAGCCAGTAAAGTGTCAATGACATGCAGAGACAGATGAATCCTTCCCAGTTGAATTCTCAGGCTCTGGTCGGGCCGCGCTGGGGAGAAAAGACACCCTGTCCGTTACAACCACCAAGCGCAGCCAGGCTACGTGATGACTGGGCCAAGTCCCAGACGTGACTTCCTCCAGCACTGGAGGGGAGGGTCCGACGGAGGAGGCTGAGAGTCTGTTGGAGGCAGCCGAGGATCGGACGCAACAGGCACAGGTCTTACATGGGAGGCATAAAGTCTGGTGGGAGTCCAAGGGAGGACGGATGTAGGGTGATGGGAAGAAAGGACCTAATCCAGAAAAAGGAACAGAAGAGCCACCTACCTGGTTAGGGGACGCTGGCCCTCCGCAGGGAAAGCTGTCAAAGAAAGGCCTGGCTAATGAGACCATGTCGTGGGGGGCCCAGGCAACTGTGGAGGCATCAGACACCTTGGGGCAAGGAGGGCACCCATGACCTAGTACACACCACTAAGTATCTCACAGTCCTGCACACACACTCATTGACACACGTGGGTGAGCAGCACCCACGGCCAGCTGAAGCTGAGTATCCTGCCCGCCCCTTTGTTTCTTCCAACTGAGCAGGGACAAGAAGGATCCCTATGAATATGCCTTTTTTTGTTTGTTTGTTTGGTTGGTTGGGTTTTTGACTTGCTTTGGTTTTTCCAGACAGGGAGTAAAGACATACACCACCATAACCCAGCTTTGTAAATCTGGTTTTTGTGTGTGAACCTATGAATTCCACTCCTGTTGCACTGATGGGAAATTGAGGCAAAGTCTCAAAGAAGCTGACAGCACAGGCTAGTGTGTTCATTTTCTCTCTACAAAAAGAGGAAAAATTGGGGCTGGTGAGATGCCTCAGCGGTTAAGAGCATTGACTCCTCTTCCAAAGCAGGTCCCGAGTTCAAATCCCAGCAACCACATGGTGGCTCACAACCATCTATAATGAGATCTGACACCCTCTTCTGGGGTATCTGAAGACAGCTACAGTGTACTTAGATATAATAAATAAATAAATCTTTAAAAAAAGGAAAAATTATTTATTATTTTATTATTAAATTAATTGTTGTATTTATTTATTTTATTAATCTATATTTAATTTATTTTTTTATTTTGTGTGCATGAGTGTTTTGCCTGCATGTGTGTGCACTACCTGTGTGTCCACTGCCTATGGAGGTCAGAAGAAGGCGTTGGGTCCGGGAACTGGGGTTGTATGGTTGTTAGCCGCCGCGTTCATGCTGGTTCTCTGCGAGGCGGCACTTAGTCCTGAGCCATCTTCTGTCAGCTCCTCTACTTTCTTTTAGACAGGGTCTCCTGTAGCTCAGGCTCGGCTTCAGCTTGCCTCGTGGTTAAGGGTGACTAAGTTAAATCATCTTACATTTCTGCCTCACTTCCACCTCCTGAGTGCTGGGCTTGCAGGCATGTGCCACTGGGATGGGTTTTGTTTCCTGCTGCCTTCTCACCCCGTAGCTCCGTGTGTTGGGTCAGCGCCACCCCTGTGCCCACTGAGCCATTAACCCTACTGAGCCCACTGTAGGGAAAAACCATAGAGGAGCTTCTATGACCCTCATGGGTCCCTCCAGGTCTGTCACAGTTCAGGAGGCATGGATCTCTCTGGCAGGGAGCTGTTGACTTTAGCCTTGGAATTTCCCAACCAAGTCTACACTGAGCACCCTGTCGACGACCTGCTTCTGACTCCTCCTGTGAGCCTCTTTTGGAGTGATCTTAGTCCCCACAGGGCCCCCATCTTCTCCAGAGCTGAGTGGCCTCTCCTACTGGACAGAGAAGAGCTGTCCTGACTTGGTTAAAATGTTGAATGCAAGGAGCGGAGGAAACGGCCCAGCTGGTGAAGTGTTTGGCTCGATCCCCAGAGCTGTGGAGTTCCCAACAGGATGGGGCTCACTGGCTGCCCTGATCAGCAAGCTCAGAAACCAAGATGGATAGCTCCTAAGGACTGGAATTGGAGGATGACCCCTGGTGACAGACACACTTGCATATGCATCTGTCTGCACACATACACATATGCATGTAAAACCCTGATCCACGTGGTAGTGCCTGACTGTAATCCCAGTACTTCGCACACAGGAACACAGAATCACCTTCAGTTTCAGGCCAACCTCGTCTACATATCCAGCACCTTAGGAGACTCTGTTTCCAACTCTTCAGGGTGGCTCACATCTCTAATCTCAACCCTCAAGAAGCCAAGACTGGAAGATCCCTAGAGAGGAAGGTTTGCTTGGGTTCAGTGCCAGCCTCCAGAGGCAGAGGCAAGCAGATTTCTGACTTCGAGGCCAGCCTCTACAGAGTGAGTTCCAGGACAGCCAGGCACCCAGGGCTATACAGAGCAACCCTGTCTCAAACAACAACAATAACAACAACAACACAACAAGAAAACTTGAGTGTGCGTGTGCGTGTGCGTGTGCGTCTGTGTGTGTGTGTGTGTGTGTGTGTGTTTACTATTTACAGTAAACGAGTCTTTGGCGAGGCAGCCAAAGTAGGCCACGAACTCCTTGTCCCCTGCTGGGCTCTCTGGGTTGACATCTTGTCTTGATGGCGAGATAGGAAGGGATTCTCTGTCCCTCACGGTGCTATCAGCAGTGCGAACAGATGGGGTCGGGAGACAGACTGGGGCACGGGAGAATCAGGGTGGAGGAGGGCTGTGATTTAGGTTTACCATGAAACCGGAGTCATCACCGGTGGGAGAGGCTGGTCAGAGTTCCTCTTTTTTCCTCTTCTTTCCCTAGGACCCAGGCCTGATCCGGTGGGGAGGCGAATGATTGGAAAATGCTGCCTTCTAGAGTCCCTAGCGAGAGCCACACCCCAGGCCTCAGCCATCAATGACAACCTTTCTGTTCTCACTGAAAGCAATTAAAGATCTGTAAGATGAGTCAGTGTTACCCATTCTAAGCTGCTGACTGCCTTGCTCCCATCCCTGGGACCCACATCGTGGAAGGAAAGAATGGACTGATGCCCTTGGACCCCCACGTGTGTGCTGTGGCACACACACACACGCATGCACACAAAAATAAGTAATGTAGTTCAAAATTTAGAATAAATCAGGCGTGGTGGTGCACACCTTTAATCCCAGTACTCGGGAGGCAGAAGCAAGTAGATCTCTGTGAGTTTGAGACCAGCCTGCTCTACAGAGTGAGTTTCAAGCCAGCCATAGATAGCTACATAGCCAGATCTTGTGTTAGCCTCCTCCTTCTACCAACAGAAATTAAGATCACAAATAAAGAGGAAAGAGGGTGGAAGAGACAACTCAGTGGCTATGAACATTTGCTGTTCTTGCAGAGAAACCAGGATTGAGTCCCGGCACCCACATAGTGGGTAAACATTATCTCTAGCTCAAATTCCAGAGGACCTGGCTTCTGAGAGCACGGTACACATGGGGtGTTCTCTCTCTCTCTCTCTCTCTCACACACACACACACACACACACACACACACACACACACACGCAGGAAAAACAGAAAAGCACATAAAATAAAAACAAATATATAAAAATAGAATCCAAGGGGATTCAACGATGTCATGAGTCCACAGAAATCCTATCCTCCCCTTTTTCGGGGTGTTACACGGGCGGATCAAACCCAGGGNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNTGACTGCTCTTCCAAGGTCTTGAGTTCAATCCCAGCAACCACATGGTGGCTCACAACCATCCGTAATGAGATCTGACCCCCTCTTCTCGTGTGTCCGAAGACACCTACAGTGTACTTACATATAATAAATAAATAAATCTTAAAAAAAAAAGAAAGAAAGAAAGAAAGAAAGAGAGAGAGAAAGAAAGAAAGAGGTGAGGGCTGGCTCTGGTCGCGCACACCTTTAATCCCAGCACTTGGGAGGCAGAGGCAGGTGGATCTCTGTGAGTCTGAGGCCAGCTTGGTCTACAGAGTGAGTTCCAGGACAGCCAGGGCTACACAGAGAAACCCTGTCTTGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGGAAGGAAGGAAGGAAGGAAGAGGTGAATAGGATAAAATGAGGTCCAATAGGTTGGGGGCATGGCTCAGTGTTAGAGGGCTTGCCTAGCAAGTGAGAGGCCTGGGTTCAACCTCTCGCACTGAAGAGGGATGGTAGGTAGCTAGGTAGGTAGGTAGGTAGGTATCTAGATAGATAGATGATAAATAGGTAGATGGATGGTAGATATATAGATAATAGATGTGGGATAGATAGATGATAGAGATATACATAGATGATAGATTATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGACAGACAAATGGTAGGTATATAGATGATAGAAAGATGAGGGATAAATAGATGGTAGATAAGTAGATGATAGTAGGTACATGAGAGGGAGAGAGAGAGAGAGCGAGAGAGAGCGAGAAAGGATATAATAAGGTCATTACGCTAATTTGATCCAAAGACAGATTGGGGTTCTTATAAGACAACTGATCAAGCAGGCCAGATATGGGGGGAACTGATCTGTAATTCTAGCACCTGGGGTGGGAGATGGAGGCAGGAGGAAGGGGAGGTCGAGGGTATCCGCAGATACTTAGTGAGTTTGAGGCTATCCCCAGCCACGTGAGACTCTGGCAAATCCTTCCGCACTAACAACAAAAATTCTGAAAGGCAAACCTCCCTTAACTCATAAAGCATGAATTGGGGCGTATGCGGGCCTTCAGAGCCATGTGGTGTGTTTGCGAACAGACGACAGGAAACACTCTTGACAGGACTCAGACCCAGAGACGAAGGCACAGCAGAGTCACCATCTGGACAGGCGTTGGGGCTTGCTGGGCCGCTCACAGGAAGCAGCGCACACCAGAGCCATCCGCCTAGGAGCTCGGCCACAGTTTCCTGCAGAGTGCGCCCTGACACACCCGGCCAAAGCAAGCACTGGCCTGTGGACAGAAAGCAGACACAGGACGGAGCCCGTTCCGGGGTCAGCTCACTGTACTTGAAGATGTGAGCCCAAAGAAGTGGGGGGTGCCACGGCGTCTTTTGCAGATGTTACTATGCCAGTTGGTGTTAGACACTTAGATATATTTTTAAGAAGAGCAGTCGGTACTCTTAACTACTGAACCATCTCTCCAGCCCCACAATGACATTCTTCAAAGAGCAGAGCTTAGAGGCACAGGCACTTGTCACCAAGCAGCAACATGAGTCAGATCCCTGAAAATCCACAGGCAGAAGGAGAGAGCTGACTCCTGTCCGTTGACCTTCATGTGAATACAGTGGTGTGTGGTGGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGCATTTATGCCATGTGTGTCAAGAGTGTGAGGAGGACCCAAGAGAGTTCCTAGACTTAAAGCTGGTTNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN MOUSE SEQUENCE - mRNA (SEQ ID NO: 2)GAGCTAAGCCGTGTTGAACAAAGGAGGTCGGGCACAGCTATCCAAGCTCCCGGGGCCACCGGGCCGCCCTCCGCCACCATGACCGCCAACGGCACGGCACAGGCTGTGCAGATTCAGTTCGGGCTCATCAGCTGCGGCAACAAGTACCTGACAGCCGAGGCGTTCGGGTTCAAGGTGAACGCATCCGCTAGTAGCTTGAAAAAGAAGCAGATCTGGACGCTGCAGCAACCTCCCGATGAGGCGCGCAGCGCGGCCGTGTGTCTGCGCACGCACCTCGGTCGCTACCTGGCCGCCGACAACGACCGCAACGTGACCTGCGAGCGCGACGTGCCCGACGGCGACTGCCGCTTTCTCGTCGTGGCGCACGACGACGGCCGCTGGTCGCTGCAGTCCGACCCTCACCGGCGCTACTTTGGCCGCACCCAGGACCGCCTGTCCTGCTTCGCGCAGAGCGTGTCGCCGGCCGAGAAGTGGAGCGTGCACATCGCCATGCACCCGCAGGTTAACATCTACAGCGTTACCCGCAAGCGCTACGCGCATCTGAGCGCGCGCCCGGCCGACGAGATCCCGGTAGACCGCGACGTGCCTTGGCGCGTCGACTCGCTCATCACCTTCGCCTTCCAGCACCAACGCTACAGTGTGCAGACGTCCGACCACCGCTTCCTGCCCCACGACGGGCGCCTTGTGGCACCCCCCCAGCCCGCCACGGGCTTCACGCTGCAGTTCCGCTCCGGCAAGGTGGCCTTTCGCGACTGCGAAGGTCCCTACCTGGCTCCGTCCGGGCCCAGCGGCACCCTCAAGGCTGGCAAGGCCACCAACGTGGGCAAAGATGAGCTCTTCGCCCTCGAACAGAGCTGCGCTGAGGTGGTGCTGCAGGCGGCCAACGAGCGGAACGTGTCCACGCGCCAGGGAATGGACCTGTCAGCCAATCAGGATGAAGAGACCGATCAGGAGACCTTCCAGCTGGAGATCGACCGCGACACAAGAAACTGTGCCTTTCGCACCCACACGCGCAAGTACTGGACACTGACGGCCACCGCACGTGTGCAATCCACTGCGTCCACCAAGAACGCCAGCTGCTACTTTGACATCGAGTGGTGTGACCGCCGGATCACTCTGAGAGCCTCCAACGGCAAGTTTGTGACCGCCAAGAAAAATGGCCACCTGGCCGCCTCGGTGGAGACAGCACGGGACTCGGAACTCTTCCTCATGAAGCTGATTAACCCCCCCATCATTGCGTTCCGGCGGGAACACGGGTTCATTGCGTGCCGCAAGCTCACGCCCACTCTGGATGCCAACCGTTCCAGTTACGATGTCTTCCAGTTGGAATTCAATCACGGCGCCTACAACATCAAAGACTCCACGGGCAAGTACTCGACCCTGGGTAGTGATTCCTCGGTCACCAGCAGCAGCGACACCCCTGTCGATTTCTTCCTTGAGTTCTGTGACTACAATAAGGTGGCTCTCAAGGTGCCCCGCCGCTACCTGAAGGGGGACCACGCTGGGGTCCTGAAGGCCTGCCCGGAGACTATCGACCCCGCCTCACTCTGGGAGTACTAGGGCCACCTGCCTCTGCAGCCGCTCTCGTCAGTCCTCCTGTTATCCTTACTCATCGGGTGGCCTGCAGCAGGTGGCAAACCCCTTGCCTTTCAAACTGGAAACCCAAGAGAAAACGGTGCCCTTGCTGTCACCCTCTGTGGACCCCTTTTCCCTAACTCACTGCTCCCCATGGGTCGGTGGCTGCAGACTGTCCCCAGGAGGACTCTGCTTCCCTCTGTCCCCTTCTTTCCATGGGGAACTCTGGCACCTTTCTTCTGACCTCAGTCAACTCTGAGCCTTATTTCCCCCCAGGAAGTGGCCTAGGAGAAGCTACAGGGCCTAGGGACTTACCCTGAGCTTGTAACTGGAAGACCCCGTCCCTATCCCCGCTCCCGCCCCCACCCCACCCCACCCCTGCTCTGGCCCCAGCCTCTGGAGGCCAGCCTTTTGGCGGGACTGAAGCCGGGCATGGCCAACCTTGCCCACAAGTGTTTTTCTGGATCTTGGCTGGAAGGCAGTCTGTCCCATCCTGCAGTGTTTGGGCCTGGCTCTTTGACTCAAAGCTAGCTAGGTGGCACTCCGTGTCGCTCCTGCACATTCTGGAAGGGCCGGGCCTCTCACCCACCTCATTCCTTTTCCCCCTGGCCTGACTGGAAGCAGAAAAATGACCAAATCACTATTTTTTTTTTTTCTTTAAGGAAATGTTACTGTTGAAACGCCCTAGGCAAGCCTGCCCTGTTGGTTGTAGTCGTCAGTGGTCTTGGCGGGAGATGCTTGGCTCCTGTCCCTGCCTCCCCAGCGGTTCCCTCCCTCCCTCCTGCCTGACCACCCCAGCTCTGGCTCTGTGATTGGTGCTCCACGTCTCCAGACACCTCGGGGCTCCTGGGCGGAGAAAGCCGATGTGCCCCTCCCTGGGAGCCCTGAGTAAACCTCAGGGGGCCCTTTCCCAATCACCCCTCCACCGACCCCTCAACACCATGCATCTCACTCTGGGTGTACTCGCTCACATTTATTTTTTTGTAACTGTCATTTCTATAACTCTGAAGACCCATGATAGTAAGCTTTGAACTGGAAAATAAAGTAAAATCAAGTCTG MOUSE SEQUENCE -CODING (SEQ ID NO: 3)ATGACCGCCAACGGCACGGCAGAGGCTGTGCAGATTCAGTTCGGGCTCATCAGCTGCGGCAACAAGTACCTGACAGCCGAGGCGTTCGGGTTCAAGGTGAACGCATCCGCTAGTAGCTTGAAAAAGAAGCAGATCTGGACGCTGGAGCAACCTCCCGATGAGGCGGGCAGCGCGGCCGTGTGTCTGCGCACGCACCTGGGTCGCTACCTGGCCGCCGACAAGCACGCCAACGTGACCTGCGAGCGCGAGGTGCCCGACGGCGACTGCCGCTTTCTCGTCGTGGCGCACGACGACGGCCGCTGGTCGCTGCAGTCCGACGCTCACCGGCGCTACTTTGGCGGCACCGAGGACCGCCTGTCCTGCTTCGCGCAGAGCGTGTCGCCGGCCGAGAAGTGGAGCGTGCACATCGCCATGCACCCGCAGGTTAACATCTACAGCGTTACCCGCAAGCCCTACGCGCATCTGAGCGCGCGGCCGGCCGACGAGATCGCGGTAGACCGCGACGTGCCTTGGGGCGTCGACTCGCTCATCACCTTGGCCTTCCAGGACCAACGCTACAGTGTGCACACGTCCGACCACCGCTTCCTGCGCCACGACGGGCGCCTTGTGGCACGGCCGGACCCCGCCACGGGCTTCACGCTGGAGTTCCGCTCCGGCAAGGTCGCCTTTCGCGACTGCGAAGGTCGCTACCTGGCTCCGTCCGGGCCCAGCGGCACCCTCAAGGCTGGCAAGGCCACCAAGGTGGGCAAAGATGAGCTCTTCGCCCTGGAACAGAGCTGCGCTGAGGTGGTGCTGCAGGCGGCCAACGAGGGGAACGTGTCCACGCGCCAGGGAATGGACCTGTCAGCCAATCAGGATGAAGAGACCGATCAGGAGACCTTCCAGCTGGAGATCGACCGCGACACAAGAAAGTGTGCCTTTCGCACCCACACGGGCAAGTACTGGACACTGACGGCGACCGGAGGTGTGCAATCCACTGCGTCCACCAAGAACGCCAGCTGCTACTTTGACATCGAGTGGTGTGACCGCCGGATCACTCTGAGAGCCTCCAACGGCAAGTTTGTGACCGCCAAGAAAAATGGCCACGTGGCCGCCTCGGTGGAGACAGCAGGGGACTCGGAACTCTTCCTCATGAAGCTGATTAACCGCCCCATCATTGCGTTCCGGGGGGAACACGGGTTCATTGCGTGCCGCAAGGTCACGGGCACTCTGGATGCCAACCGTTCCAGTTACGATGTCTTCCAGTTGGAATTCAATGACGGCGCCTACAACATCAAAGACTCCACGGGCAAGTACTGGACGGTGGGTAGTGATTCCTCGGTCACCAGCAGCAGCGACACCCCTGTGGATTTCTTCCTTGAGTTCTGTGACTACAATAAGGTGGCTCTCAAGGTGGGCGGCCGCTACCTGAAGGGGGACCACGCTGGGGTCCTGAAGGCCTGCGCGGAGACTATCGACCCCGCCTCACTCTGGGAGTACTAG HUMANSEQUENCE - GENOMIC (SEQ ID NO: 4)TTGCATTTGAAGCTACCATGACTGCAAGAGGGAGTTCCCGAAGGGGTCTGGGAATGGCCCAGGGAAATAGGGGTGAGGTGAGACTCCACTGCCCCGACAGTGCCCATGTATGAATTAGAAAAAGTGGGCCAGGCGTGGTGGCTCACACCTGTAATCCCAGCATTTTGGGAGGCTGAGTGGGCAGATCATGAGGTCAGGAGTTCGAAACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCTGGGCTTGGTGGCACACATCTGTAGTCCCAGCTACTCAGGAGGCTGAGGCAGAAGAATCGCTTGAACCTGGGAGGTGGAGGTTGCAGTGAGCCGAGGTCATGCCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTTTGTCTCAAAAAAAAAAAAAAAAAAAAAAAGAAAAGAAAGAAAGAAAAAGAAAAAAAGTGGGCCAGGTGTGGTGGCTCATACCTGTAATCCCAGCACTTTGGGAGGCTGAGGTGGGAGGATTGCTTACAGCCAGGAGTTTGAGACCAGGTTGGACAACATGGTGAGACCTTGTCTTTACAAAAAAATACAAAAACCTATCTGGGCATGGTGTTGCATTCCTTTAGTCCCAGCTACTTAGGAGGTTGAGGTGGAAGGATCACTTGAGTTAAGGGAGGAGACCACCCCTCATATTGTCTTATGCCCAATTTCTGCCTCCAAAGAAAGAAAAAGTAAAAACTAAAAGGCAGAAATGAAAACCACAGGCAGACAGCCCAGCGCCACACCCTGGGCCTCGTAGTTAAAGATCGACCCCTGATCTAATCGGTGATGTTATCTATAGACTACAGACATTGTATAGAAATGCACTGTGAAAATCCCTATCTGGTTTTGTTCTGATCTAATTACCGGTGCATGCAGCCCCCAGTCACGTACCCCCTGCTTGCTCAATCACGACCCTCTCACGTGCACCCCCTTAGAGTTGTGAGCCCTTAAAAGGGACAGGAATTGCTCACTCGGGGAGCTTGGCTCTTGAGACAGGAGTCTTGCTGATGCCCCTGGCCAAATAAACCCCTTCCTTCTTTAACTCGGTGTCTGAGTTTTGTCTGCGGCTCATCCTGCTACAGAGTCTAGGAGGCAGAGGTTGCAGTAAGCCAAATTCACGCCACTGCACTCCAGCCTGGGTGACAGAGCAAGACCCCACCAAAAAAAGAAAAGAGGCCAGGCGCAGTGGCTCACGCCCAGCTAATTTTTGTACTTTTAGTAGAGACGGGGTTTCACCATGTTGGCCAGGCTGATCTCAAACTCCTGTCCTCAGGTGATCCGCCCACCTTGGCCTCCCAAAGTGCTGCGATAACAGGAGTGGAGGCTCAACTTTTTAAAGAAGAAAAGGACGAATCAGGACAGGAGACAATTACAAGCTCTGTTCATTCGGAATTCTCATTGGCTTACAGAAATAACTTTGGCTAGTGATTGGTTATATGTTGTAGACAGACCCACAGGGTGGATGGCGTCTGTGGCCACTTGGGCATTAGCTGGTCCAGAGCCCAGAGTCCATGTAGCAAGTAGCTTCAGGACGTAATTATTTAGCTCAATAGAAAGTGAGATGTGACTGCTGTTACTTTTTTTTTTTTTTGAGACGGAGTTTCACTCTTGTTGCCCAAGCTGGAGTGCAATGGCGCGATCTCGGCTCACTGCAACCTCTGTCTCCCAGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCGTGTGCCACCAAGCCCGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACTATGTTAGCCAGGATGGTCTCGAACTCCTGACCTTGTCATCCACCGGCCTCGGCCTCTCAAGGTGCTAGGATTACAGGCATGAGCCACCACGCCCGGCCTTTTAACTGCTGTTACTTTTTTTTTTTTAATCATTTTTATTCTGCTAGTTCCATAAAAGCAATGTAAACACCAGCATTCTATACATCTTGCTGGTGAACTCACATAATGCTTAGTTCCCTGATCCTTTGACCTCCTTGTCTTCTCCAGTTATTTTCTGTTTGGACCACTGGCCACAGGAATGGAGTGGGGTTGGGGCTTAGGAGAGAGCAATGTGGCTTTTTGGTATGACTTGTTTCATTGACTGCTGTTACATTTTAAATGCCTTTCTGGGCCTGATAATTTAAGGGGGCTGGCATTTCTCACATCAAAGGGCAAAGGGTTTTTTTGTTTGTTTCTCACTATTGCTCAAAAGCCACATGTGTCAAGGACAGCTCTTGTTAACGGGCAGAGAAGCTTATAGAACCTTTCCAGGGCTGGCGCGGTTGTTCATGTCTGGGGGACAAGAGCGAAACTCCATCTCAAAAAGAAAAAAAAAAAAAAGAACATTTCCAGGCCAGGCACAGTGGCTCACACCTGTAAGTCCCAGCACTTTGGGAGATTGAGCTGGGAGGATCACTTGAGGCCAGGAGTTTGAGACCAGCATAGGCCACATGGCAAGAACCCAGTTTCTACAAAAACATTTTTTTTTTAAATTAGCTGGGCTCGGTGGTGCACACTTGTGGTCCCAGCTACTCGGGAGGCTGAGGTGGGAGAATCGCTTGAGCCTGGGAGGCGGAGGTTGCAGTGAGCTGTGATCGCACCACTGCATTTCAGCCTGGGCAACAGAGGGAGACTCTGTCTCAAAAAAAATCAAATAAAGAAAAAAGAACATTTCCATTATTGCAGAATGTTCTATTGGACGGCGCTGGGCCAGATGCCTGCCCCAAGCCCTGGGACACCCAAACCTGGTGAAAGTGCCAAGCTCCCATCTGGGGGTGCTCACGGAAGGGGCCGGGAGCTGGGATTACAAGCGTGGAGGCAGGCGCCACCCCAGAGGAGGTGGGTGATGTCTGAGCCAGAGTCTTTGGGATGAGCAGGGCTTTGGCAGGCAGCTTTGTTGGGCAGGCAACAGGCACAGCAGGTGCAATGGCATCGAGGTTGGAGAGGTGGACTGGCGGGGAGAAGAGAAGGGAGGGTGGCAGGAGAGATGGGCAGAGGCCCCCCAGGAGCCCAGAGCCTTCAGGGCTTTGGGCCCTCTTGGGGCACTGGGGAGCCACGGGAGAAGTGTGGGGTGGAGAGGGGCGCCCTGGATTTGACCACCTTCAGGAACCTACCTTGGCTGCCCGGGTGGGTGGGATGGAGGTGATGAAGGTGGAGGTCGTAGCATTGTCACTGAGAGCGATGCTTATTCTGATTTTTGCCCCCGTGAGCCTCAGAAATCGGTCAGAACAGTGCTCGGGCTGGGCGTGGTGGCTCACGCCTGGAATCCCAGCACTTTGGGAGGCCGAGGCGGGCGGATCACCTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACATGGCAAAACCCCGTCTCTACTAAAAACACAAAAATTAGCTGGGTGTAGTGGTGCATGCCTGTAATCCAGCTACTCCAGAGGCTGAGGCCTCCCTGGGAGGCGGAGTGCAGTGAGCCAAGATTGTACCACCGCCCCTCCAGCCTGGGTAACAGAGTGAGACTCTGTCTCAAAACAAACAAAAAAGAACAAACCAAAACCAGTGCTCCAATTCACCTTGCTGAATTGGAGAAGAACAGGTGCCTGGGTCCTCCCGGCTGACGGTGACGTCACTATGAGCCACCACGCCTGGCCCGGTGGGTGTTTACAGCAGAGGTGGTTCAGGGAGGAGTGAGTGGCAGATGGTGCAGGCTCAGGGAGGAGTGAGTGGCAGGTGGGGCCTGAGGCCAGAGGCAGGAGGACCGTTCAAGACTGAGGTGTCTTGGGCACTGGTGCCGGGGCCGGGGAGAGCCCTGGCATGCCGGGCCCCGGCCCTCAGTGAAAGCAGGATGAGGTGGCGGCCAAGCAGGGAGGCCAAGGCCTGGCAGCAGCCGGCAGCCCCTCTCCTGGCAGGGACATCTTGGCAGGAGCCGGGCTCTGCCCAGGGCGCTAATGTCCTCTTAATTAGCCAGGCACTTGCCAAGCACTTGCCGCTGCGGCCTCACTTTGCAGAACGCACTTGGGTTTGGAGCAGGACCAGCATCCCCCACCCGGTGAGTAGGGGGGATGGCCAGGTGAGTACCATGGCCAGAAGGTGCGGCCTCTGAGTCCCCACTGAAGCCAATCCAGGCCCCGACCTCTGGTCATCATCAACAGAAGAGTGACAGAAACAGAAAAGATATCAAGGAACACCTTTTCAGCGCCAGATTCCAGGTCCCCCACCTATTTTCCTTTGCTCCTCCCTTGCCTGGCTCTGCCCCCTTGAACTCTTATTCACCCAGTGTAGGCATCACCTCCTCCTGAAGGCCCTCCTGGACTGCACAGTTAACTCTGGAGCCTCCCCTGCACAGGGCAGCTCATCTATGGATCCACAGGTGAGTTCCTGTCTTTCAACGGTTACAGTTTACGTCCTCGAGCAGTCGTGGCGAGGTCACACCTCCACCCACATCCCTCTTTGCAAATCCCATGGGAACTATGAGCCTGGGTCCCCCAAACTGCATGTTCCCCACTTAAAGCTGGGCCAGATCCTGTTTGCTGTATCCAGGCCTCAGTTTCCCTGCTTGTAACCAGAAGTCCATGCAGCCAGAAATTGTCAGGGAGCTGGGCACGGTGGCTCATGCCTGTAATCCCACCACTTTCACAGCCTGAGGCAGGAGGTTCACTTGTGATCACGAGTTTGGGACCCCAGCCTGCGCAATACAATGAGATCCCTGCCTCTACCAAAAAATTAAAAACAATTAGCCAGGCCTGGAGGCATACACTTGTAGTCCTAGCTATTCAAGGGAGGCTGAGCTGGGACCATCACTTGAGTCCAGGAGTTTGTGGCTGGGGTGAGCTCTGATTGTACCACTGCACTCCAGCCTGGGTAAGACAATGAGACCTTGTTTTATTTTATTTTATTTTTATTTATTTTGAGATGGAGTCTCACTCTGTCACCCAGGCTGCAGTGCAGTGCTGCAATGTCGGTTCACTCCAACCTCTGCTTCCCGGCTTCAAGAGATTCTCCCCCCTCAGCCTCCCAAGTAGCTGGGATTACAGGCGTGTGCCACCACGCCTGGCTAATTTTTTGTGTTTTTAGTAGACACAGGGTTTCACCATGTTTGCCAGGCTGCACTTGAACTCCTGACCTTAGGTGATCCATGCCCCCTTGGCCTCCTAAATTGCTGGGATTATACGCATGAGCCACCCGGCCTGGCCGAGACCCTGTTTTAAAAAAATTAATCAGGTCCAGTGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGACGGCAGATCACCTCAGATCGGGAGTTCGAGACCAGCCTGACCAACATGCAGAAACCCCGTCTCTACTAAAAATACAAAATTAGCAGGGCGTGGTGGCGCACACCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCACTTGGACCTGGGAAGCAGAGCTTGTGCTCAGCCGAGATTGCACCATTCCACTCCAGCCTGGGCAAAAAGAGTGAAACTCCATCTCAAATAATAATAATAATAATAATAATAATAATAATAATAATAATTGGTAGAGATGTTGGTAGAGGCAGGACAGTGGGAGTGACAGCCTGGTCCTGTCCTCCCGGGCTCTGGCTGACCATGCTGTAGTCTGGCTCAGGGCCCTGGAGGGCACAGCTGTCCTGTCCCCCTGTGGTCAGCCGGGAAGCCAGGCCTGGCAGGACTCCTGCCCTAGAATCAGCTCCTCCCACTCCCCAGGGTCCCATGCAGGGCGCTGGCCGTACCAGGCCTCCTCGCGGGTGCCACAGAGCCACCGGCTGCACAGCAACAGAGACGCCATTCACAGGCTCTCGGCCACGAGGCCGCTCATTTACAGAGGGCTGAGCCGCTCACATCTGTGCGTTTGTAACATGGACAGCATTTCTCGTCCCATACAGACGCCTGGGCCAGCCACATTTATCTCCCCTTCAGAGAAGGGAAACGAGGCTCGGGAGGGAATGAGGGATTGGCTTGGGGTCACACAACTTTAATGATGACCCTGGGCAGGAAGCTCCCAGCATGGCAACAGAGACTCAGGGCAGGCTGCGCATGGTGGCTCACACTTGTCATCCCAGCCCTTTGGGAGGCAGAGGTGCAAGGATCACTCGAGCCCAGGAGCTCAAGGCCAGCCTGGGGAATATAGTGAGAACCCATCTCTAAAAAAAAAAAAAATAGGCCGGTCGCGGTGACTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGTGGATCACGAGGTCAGGAGATTGAGACCATCCTGGCTAACACGGTGAAACCCCGTCTCTACTAAAAATACAAAAAATAGGCCGGGCGTGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCCGGCGGATCACGAGGTCAGGAGTTCGAGATCAGCCTGACAAACATGACGAAACCCTGTCTCTACTAAAAATACAAAAATTAGCCGGGCGTGGTGACACGCGCCTGTACTCCCAGCTACTCAGGAGGCTGAGGCAGGACAATCGCTTGAACCATCGAGGTGGAGGTTGCGGTGAGCCGAGATCGCACTACTGCACTCCAGTCTGGGAGACAGAGTGAGACTCCGTCTCAAAAAAAAAAAAAAAAATTAGCCGCGCGTGGTGGCGGGCGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGTAGCAGAATGCCGTCAACCCGGGAGGCGGAGCTTGCAGTGAGCCGAGATCGCGCCACTGCACTAAAGCCTGGGCAACAGAGCGAGACTCTATCTCAAAAAAAAAAAAAAAAATTTAGCCGGGCATGGTGGTGCATGTCTGTACCCCCAGCAATTTGGGAAGCTGAGGTGGGAGCATTGCTTAAGCCCAGGAGTTTGAGGCGGGAGTGAGCTGTGATGGCACCACTGCACTCCAGCCTGGGTGACAGAGTGAGACCCCGTCTCTCCCTATCCCCCGCAAAAAAAAAAAAACAACTCAGGGCTTTCCCACCCCTGTCCTTGCACAGATGAAGAACCGAAGCTTCTAGAAGGGGTATATTTTGCCCCCAGGCCCCAAATCCTGGTCTTTGGACTACAGTCAAGACCTAGCACAGGGCTCAGCCCTAAAAAAAAGCTGTTGAGGAGGGTGTCAGGCTGCAACGTTGCGGTGAGAAGGGGGTCCCCAGGGAGGGCGCAGCAGGAAGCCCCAGGGAAGTGCCTGGGACAGGGAGGTTGTGCAGCCAGAAGGAGCAGCCCGCAGCCTTTGGTTGTTGACTCCTGCTTTGTAAGTGGCAGTCTGGTTGGGTAGGACAGGGTCCGACTCCTCACTCAGGGAACTGAGTCCAGGGTGAGCTCAGCAGCCCTTCCTGGTGGCCTCACTTTCCCCTGCAGAGCCTGCTGCATGGTGTCCAGTCGCCAGCCTGGCAGGAGCTCAGGACTGGCCTCACCTCGTGCCACCCCCTCGTACCAAGGTGGCTCAGATGGCACCTGGGTTCCCGAAGGGCCCAGGAACACAGCGTCCATGTCCCCATCCTTCCCCGGAGGGACTTGGGGTCGCGCCTGCACGAAGGATCATGTGACTTGTTCAAGGGCAGCTTGTCCTCCCCCGGACACAGAGGTGCCCATCGTAAGCGAGATGCAGGCAAGGTGAGGACAGGGCATGGTGCCGAGCAGGAATGATTTTCGAAAATGCTACTCTGTGGTCGGGCACGGTGGCTCACTCCTGTAATCCCAGTACTTTGGGAGGCCCAGGCGGGCAGATCATGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCCTTCTCTACTGAAAATACAAAAAACTACCCGGGCGTCCTGGTGGATGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAACCCTGGAGGTGAAGGTTGCAATGAGCCGAGATTGCACCACTGCACTCCGACCTGGGCGACAGAGAAAGACTCCGTCTGAAAAACAAACAAACAAAACCCCGAGATTCTCTTTTCCCCCGTCCGGAGCTCTATGGCCATCTGGAGCTCGTTCTGTCCACAAGGACACATTTCCTGGCAGCAGCTGTGGACCAGGGCTCACTCACTCACATCTGTACCCAATCTAGAGCAGGACAAACACCTATCACCTGCACTGGCAATGGACAGAGGACACTGCCAGCCCCATCACCAGAGGCATTCAAGCCAACGCATTTTCTATCGTCTATTTATCTATCTATCTATCTATCTATCTATCTATCTATCTATCTATCTAGATGAGATCTTGCTATGTTGCCCAGGTTGAACTCCTGGCCTCAAGCGATCCTCCTGCTTCAGCCTCCCAAAGTGTTGGGATTTCAGGTGTGAACCACTGTACCTGGCTGGAGTGCAGTGGCACTGTCATAGCTCACTGCAGCCTCCACCTCCTGGGCTCAAGGAATCCTCTTTCCTCAGCCTCCTGAGTAGCTGGGACCACAGGCATGCACCATCACACCCAGCTAAACCTTCATTTTTTCCATAGTATATGCCTCAGGGCAGAGCAAAGAAGCACAAAAACATGTTGGCTTGCGGTTGAGGGCTGATGGGAGGGGGTTCTGGCCAAAGCCCAAAATTAACAGCCACAACGTCAGTGTCTGTGGGAGGGGTTGCCAGGGGCGTGCGGGTTCTGGGGCTCAAGGCCCTGCCGGTAAACCCATTTGAAGCAGGATGGCAAGAAGGTGACACCATCTTCCCCCGCGCACTGAAAGCCCCTGGCTGGGATTGCCTGGCGCAGACACAGGCTCGGACCAGCCCCAGCAATCCCAGTTTATCAGCGAGCCGGCTGAGGGCCCGGAGTTATCTCAGTGCCCGGCCTGAGACCTTGTGGGCAGCCTGTGGTCATGCTGGCATTCCAGGGGCCTTTTGGCATGTGGGGAATGTCCAGGAAAAGCCTCAGCCTTCGGTGAGGCGCAGAAAAGGGAAGTGTCCCTAGAGGGGGTGGGTGAGGGCGTGGGAGGTCGTGTCTGCAGGGAATGTCCCCTTTGCGCGAGGAGGATGGAGGGTTGGGATTCTGAGGATGGGGGCGGGGGCTGTAGCCAGCACCATGTCCCTCCTGTGTGACCAGCTCAGAGTCCCATGAAATTGGGGCTTGGGAGGGGAAGGGACACTGGCCTGGGAACCAGAGACCTGGGCTGGTCTGGCTCACAGTTGCTGCACCTCTGTGATCCGTGTCAAAAAACGAGAACACCAATTCCTGTCCTGCCCACTCACCACCAGGTGGGACCTGAACCCTGGCATCGCCAGCATTGGGAATGTCCGCCACTGACTCAACCACTCTCCCGGAGACCTATTTGGGCCACCCGAGGCGGGTGCCTGGGCCACACGGAGGGGTCCTGGTGGTCTTCAGGGCAGCGGCTGTGGGGCTGAAGCCTCAAGGAACCACATCTCTGCATAGGAGCCCCAGGCTGCAGGGCCTCGGAGACAACCTAGTTGGGCGTGTTGGGGTCTGTGGGTCCCACGTCCTGGCCTCACCGGGTCCCCACCGCGCTGTCAGCTCCCAGCCTCTTTCCCTCGTCTCCCTCTGGGCTTCTGTAAGGCTATGTGCTCCAAGCCCACCTCCTCCAGGCAGCCCTCAGACCCCCACCTTCGCCCAGTACCGATCTGCACCGTGGTCTCTGAAGTCTCCATCGTGACCTCAAACCTCGCTCGTCCTTGCTCCTACCGAGGCTTCGGGTCGGGGTGTCCGACGTGGGGGACATCCGGGGGGGTTAGGTGGCTGGCGCGGGGAGCCGGGGTTGTGAGGGGTGATGTCCTCAGGCGGCGGCGCTGCGGGGTGCGGCGAGGACACCGGTGGGGTGAGAGCACCGGCGGGGCAGCAGCGGGGGCCGCAGCGCCGGGTCCCTCGGCCCGGGGCCCCTCCCCCGCGGAGCCAGGGGCGGGACAGGGGGCCCTGGCCTGGTCGCCCTGACGTCACCTCGCCTATAAAATGTCCGGGGCGCCGCTAGCTGGGCTTTGTGGAGCGCTGCGCAGGGTGCGTGCGGGCCGCGGCAGCCGAACAAACGAGCAGGCGCGCCGCCGCAGGGACCCGCCACCCACCTCCCGGGGCCGCGCAGCGGCCTCTCGTCTACTGCCACCATGACCGCCAACGGCACAGCCGACGCGGTCCACATCCAGTTCGGCCTCATCAACTGCGGCAACAAGTACCTGACGGCCGAGGCGTTCGGGTTCAAGGTGAACGCGTCCGCCAGCAGCCTGAAGAAGAAGCAGATCTGCACGCTGGAGCAGCCCCCTCACGAGCCGGGCAGCGCGGCCGTGTGCCTGCGCAGCCACCTGCGCCGCTACCTCGCGGCGGACAACGACCCCAACGTCACCTGCCACCGCGAGGTCCCCGGTCCCCACTGCCGTTTCCTCATCGTCCCGCACGACCACGCTCGCTGGTCGCTGCAGTCCGAGGCGCACCCGCGCTACTTCGGCCGCACCGAGGACCCCCTCTCCTCCTTCGCGCAGACGGTGTCCCCCGCCGAGAAGTCGAGCGTCCACATCGCCATGCACCCTCAGGTCAACATCTACAGCGTCACCCGTAAGCGCTACCCGCACCTCAGCGCCCGGCCGGCCGACGAGATCGCCGTGGACCGCGACCTGCCCTCCGGCGTCGACTCGCTCATCACCCTCGCCTTCCAGGACCAGCGCTACAGCGTGCAGACCGCCGACCACCGCTTCCTGCGCCACGACGCGCGCCTCGTGGCGCGCCCCGACCCGCCCACTGGCTACACGCTGCAGTTCCGCTCCGGCAAGGTCCCCTTCCCCGACTGCGAGCGCCGTTACCTGGCGCCGTCGGGGCCCAGCGGCACGCTCAAGGCCGGCAAGGCCACCAAGGTCGGCAAGGACGAGCTCTTTGCTCTGGAGCAGAGCTGCGCCCAGGTCGTGCTGCAGGCGGCCAACGAGAGGAACGTGTCCACGCGCCAGGGTGAGTGGGGACGCTGCCCCCGCCTCTCCTGGTCCGTGCACAAAGCGCACCCCACCCGCGCCCCTCCAGCCTCCCGCCCTTTCTCGCTCGCGGCGCCGCTGCGGTCCGGAGCACTGCCCATTGCCCCCCCGCTAGGCACCCGCCCTACCCCGCCTGGAGGGGGCGAGGAGTGGGGCTTTGCCCATCCTCGCGTGCCGCTGCCCACCTCCCACCCCGCGCTGGGATCATGGGCTCCCCTAGGCCCCCCCGAGTCGCAACCGTACGTGCACCCTCCTAACCCCCCCCCCCGCCCAATCTTGGCTCTCCCCACGCGCGCTGATCCCTCGGATCAGCTGTCCCAGCTCTTGCGGAGTCCCAGCCCCTCACCCATTTCCTCGTGCCCCTCCCCCCGCCGGCTGTCCTGGAGCTCGGGGGTCCGAGGCAAGGGTCGCCACCCGCAAGGGCGCGCCTCCACCCCCACCGGCAGCCTTTCGCGGGCGACATGGCGGAGGTTAGCCAGGCCTTTCATCCCGGCGGGGCGCGCCTCCACCTCCCCGTCTGCCCGGCCTTCCTCCACCTCCTCCCCCTGCCGGGCGGGCTCCCCCTCCCCTGGTGGGGGGGGGCGCGCGGTGTCAGCCCTTCCCCCCAGCCCCTCCTCCCGCGTCTGCCCCGCCCTCGAGGCCGCGGCCTTTGTGAGCACGGGGGCGGGTCGCCTCGACTGCCTCCTCCCTCGCCCCCTTTGTCCTCCTCCATCTCTGCAGATGGGAAAACCAGATGCGGCGGCGCGGGGGAGGGGATCGGCTTTTGCCGTTCACCCCTGCAGACGAGCCCCCCGCGCCGCCCCCGGCCCCAGGGCTCGGGTCCCGAGGTTCCCCAGGAGGCGGTCTCCCTCCTCGCGCCGCGGCCCGGGAACGGCGTGGCGCGGATGGCGGCCCTCCAGGCACCCCGCCCTTCGCCCGCCGCGCGCGTCTCCAGGCCGGTGCGCTGAGCTCCGCTCCGCGGGCGACCGAGGGCGGCTTCAGCGCGAGCCGGGAGACCCCAGGCCAGCTCCCTCGGGAAGCCCCTACCCTCTGGTGAACCCATCCCCTAGGGCGCTCGCCGGGAACAATTGACTGCAACTCGATCCGTCCCCTCCGGGGCCTCCTGCAGCCACCGCTATTTGCGACCGGCCTGTCCCCCACTCTTTCCCTTCTTTCTCAGATTCTCCCCGAGGGGCTTTCTCTTCCTTTTGGCGTCCTCTTCCACTCCTCGCGGAGAAGCTGTTCCTTGCTTCCAGACAGAGGCCCCGCTGGAGGGAGCCGCGTGGGGGGATCTTTTTCCCTGGATAGGAAGTCGGACCCCAGGCCTTGGACATGGCTGGACGGGAGCCCAGTTTGTGTCCTCATCCCTCCTCTTGGAAGGAGCCCTCCTGACGGCCCCCCTCTTGGCTGTGGGCTCTGCAGGAGGGGGAAAGACCCCCCATGGCAGTGCGGGTGAGGGTGGAGGCCTGGGTGGCCTAATGGCCATTTTGTGCCTGAAGTTTGCTACCTTAAGTCCCAGAGAGGTGAAGCTGCTTGTCATGGGTCACACAGCAAGTGACCACAAGGAAGCAGCATGCAGAAGTGGGTGCATTTGGCTCCAGAAACCCCGTTTCCTGTTTCCCACAGCGCATGGCGGGCAGAGCTCCTCACCTGATCAGCAGGCATTGAGCCCTACTAAGGGGACCTGCTGAGCCATGAGTGAACCAGTGGGGTTCACGTTCTCTTCGGGACATTACGAAGTGTCAAGGAAAAGGCAGCGGGTACAGGTTATTAGATGCCTGAGTCCTTTCTGAGCAGGACATTTGAGCTGGCCTGAAGCATGAATAGAAGGTGGCAGGTATGGGGGGGGTGCTGTGTGGACCAGCGTTGTAGGCTGTGGGTGTCTCCTGTGCAAAGGTCTTATGCCAGGAAGGTACAGAGAAAGCCCAGTGTGGCTGGGAGGAAGCTTGTGAGGTCTGGGCCACGGCACCTTGGGTGAGAGCTTAGTGCAGGGCTATGGTCCTTGCCTTGGGGTTGCAGCCACAGCCTCCCGTGGGGAAGAAGTCGCAGAAGTAGGTGGCCTTGGCCCTCCGGGCCAGGAAGTTGCAGAGAGCCTCAGGGTGTTTTTGGCGAGCCTGGGCAGATAACTCCCCTCTCCTGAGAAGCTTGCTGGGGGCGTCTGGTGTGTGATTCAGGCTGATAGGGTGGGAGCAACCAGAAATTGCAGCCAGGACAGGTCGTCGTGATGGCTCAGCTTGGAGTTGAAAGGGATGTGGGACGGCGCGGGGCTGGGGGTACTTGGGGGCCGAGGTTGCGGCTCCTCTGGCCTCAGATCTTGGGGTCCTTATCTCGTTTCTATGTCAGCCAACTCCCGGGGGGCTTTTGGGAACTGGAGTCTGCAGGGGTGGGCGTGGGGGGCGTGTCTGCAGAGCCCATTTTGGACGGGCCTGCGTGGCAAGGGGGAGGCGTCTGCTTCCGACACACATGCTGGGGAACGCCAGCCAGGAAGGGGAGGATCCGGACTTAGCTGGCAGGGGGGATGTGAATCATCTCTGCAGGCCTGCACGGGCGGGCCCGGTGCGGGCAGGGTGCTCCCCTTTGAAAAACGCTGCGCCCTGCTCTTCAGCCTCAGTTTCCCCATCTGTAAAGTGTGCATTCCAGGCCTCCTTGGGCTGGCCCACACCTGCCCTGGGCAGGGCCTTTCAGCCCTTCACACCAGAGGCTCCGTCAGCTGAGTGAGTGCTCCTTTGTCCTCCCCCCATGCCCCAGGCTCCTCCCTGCTCCCCAGGATCCACACCTACCCTGGCCCCGACCCTGGGCCATGCCTCACCACACTTCCTGTCTTCTCTCACATCTCTCACATCTGGGAGTCCTCTCCCGCCAGCCTGTGCTTGCATCTGGGGATCCATGCCAGGGATACGACCTGTCCTCCCTGCTGGCTTGGGACATGCCCTCTCCCAGCCACTCTGAGGAGGGCTGACTGAGGAAGGGCTCGTCAAGCTGGGCTTTGCAGGATGTGTAAGAGTTCTCCCCACGAGGCGCAGGGCATTCTGAGCCCAGGGAATGGCTTGTATAAGGATGCAGAGGCATTTGAAATGGCCAAGTAGTTGCAGGAATCGACTGGAAACCGGGGTGGTAAGGTGAAGCCATAGAACATTCCAGGCCCCCTCCCCTAAATGAGATGGAAGGAGTGCCTGTTTTGAACAAGCCAGGGGCATCTGGGGACCGTTAAGGCCTGGGGGTGGTGATGGGGACTGGAGGGTGTGAGGCAACCAGGGGGTGCCCCTCTGAGCCACCACACACAGAATGGTTCAGAAGGCCAGGCACACTGGCTCTCGCCTGTAATCCAAGCACTTTGGGAGGCCAAGGAGGGAAGATGGCTTCGGCCAAGGAGGGAAGATGGCTTCAGCCCAGGAGTTCAAGGCCAGCCTGGAAAACATGGCAAAACCTCTGTCTACAAAAAATACAAAAAATTAGCCAGGCATGGTGATGCACGCCTCTCGTCCCAGCTACTCAGGAGGCTTAGATGGGAGGATCACTTGAGCCGGGCAGTTTGAGGCTGCAGTCAGCCGAGATCGTGCCACTGCACTCCAGCCTGGGCAACAGAACGAGACCCTGTCTTAAAAAAATTTTTTTTCGCCTGGTGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGTCCAACGTGGGTGGATCACCTGGAGGTCGCGAGTTTGAGACCAGTCTCACCAACATGGAGAAACCCCATCTCTACTAAAAACACAAAAATTAGCCGGGCGTGGTGCCGCATGCCTGTAATCCCAGCTACTCTCGAGGCTGAGGCAGGAGAATCCCTTGAACCCGGGAGGCGGAAGTTGCAGTGAGCCGAGATCGCACCATTGCACTCCAGCCTGGGCAACAAGAGTGAAACTCCATCTCAAAAAACAAAACAAAACAAAAAAAACAACCAAAACAAACAAACAAAAAACTGTAATTAAAATAATTAAAAGAAAAAAGTTAAAAAAAAAAAAAAGAGAGGATGGCTCAAAGGCTGGAAACAGGGAAGGCCACTGTGAGGGGAGGACAGGCAGGGCTAGACCTCTCTGGAAGGAGGAGGGAGAGGTACCCCTGGGCCCGGCACAGGAGACTCTTAATCTCCTGGCTCCCGGGGGCTTCTGTGCGCCTGTGACTCAGGATTTCTGTGCCTCTGTTGATGAAAAGAAAAATCCTGAAGAAAACACTGTTCCCATAGTAACACAGCTCTAATTAGAGACTCCAAGGCCAAGCGAGGGCCTTGGAGCCAGGAGGGGCCCTGCTCTACTGCGCGGACGACACCCCTTTCCCCTATCCCTCCCTGCTGGGGTGTGGCCTGATGTCTACGTGGCACCAGGCCCCTAAATCCTTTCAACATCCTGGCGCACCGGAGACGCTGGGCCCTTTTGACAGGTGGGGAAACTGAGGAAGGTTGCACCGAAGGCACTCATCCAAGGGTGCCTGGCCCCCCGCGGTGGGTGCCTCACTGGCTGGCCTAAACCTTTGCATCAAACCAGTTCCAGGATTGAACGCAACAGGCTGATGCGGACTGAGTCGTCGTACAGATGGCGGCAGTTGTGTGGCCCTGGGCCCAGGAATGGCTGGGAAGCTCCCTTTCTTCTCTGGCTTGGGGGATGAGGTTAGTGTAAATTTCATGGAGTTGCCAGGAGGATTAAGGCCGACGTGCATTCACACGTGGCCCCGTGGCTGCCGCCAGTTAAGCCCTGCGCAGCCATTGGAAGTCTCATTGAGAAGGAGCCTCCCGGCTTCCTGCATTTGTTCCAGGCGGGCTGGTAAGCGCCCTGCTTATTTGCAAGGCTGTGTGAGGACGAGCCCTGTAAACCCTAGCACGAGGCTGTGCTAATGTGGTTTCTGTTCCACTGTCTCCCCTTCTCCTTTTGCCCCTCTTTCTGGGGAACCTCGAGCCCCTGATGCCCTCTGTTTTTTCCTGCTGCTGGGGTGGACCTAGAACCTCTCCCTCCATCCTTTCTGCTGCTGGGGTGGGCCTGCAGGAGGCTGTCCTCTTACCTGGTCCCTAACTTCCCTCCGATCAGCGGGGCTTCAGCGCAGCCCCAGCGCATTGGACAGCTCGTGCTCTGTGGCCGGCACAGCCCAGGGCCCAGGGTGCGGCCCCTGCCTGTAGGTAGACATGCAGGCCCTTCTGAGCAGAATGAGGGGGCGGTGAGGGCAGCTGTGCGGGTGTGGCTGGCCTCACGCCTCCCTGCAGCCCTGCGGCTTCTGTGCAGTGGGGGTGGGGCGGGCCAGACCTTTCCAGGGCCTCTTCGCTGGTGGAGGGCTGAGTGAGCAGAGGCCCCAGCCCTCGTGTTCCCTGGGGTCTGCCCTTACGATGGTCCCGGCACCCTGGGGACCCAGCCCCTGCTCACCTTATCCTCCTCCCGTGCTTGGCTGGGGTGTGGTGGCTGAGCCAGCCCACCCAGTGCGGTGGATGCTCGTCGGAGGGCAGAGGGTGGGCTACCGGCTTAAGGGGCCCCAGGGAACCTGGGGGGTGGAGCCCAAGGGGTTCCAAGAAGGGGCGGGGCCAGGAACCCATAGACAAGAGGGTGGGGCAGGGAAAGGGCGTGGCAAGAGGGCCACCCACCTCCGGTCCAGAGAGCCAGCCAGACCCTTACTTTCTCTTGCTGTGTGACCTTAGGCAAGCACATGCCACCACCGGCCTTAGTCTCCCTCTTTGTGAACTAGGATGAAGATCCCCACCTGTGGAGCAGATGTGGGGCTGCATGGTTGGGTCAGGATGGAACAGGATGGGGAGGCCGGGCGTGGTGGCTTACCCCTGTAATCCCAGCACTTTGGGAGGCAAAGGTGGGAGGACTGCTTGAGTCCTGGAGTTTGGGCAACATAGCGAGACCACCCCCATCTCTACAAAATAATGTTAAAGTTAGCCAGGTCTAGTGGTGAGTGCCTGTGGTCCCACCTACTGGGGAGACTGAGGCAAGAGGATCCTTTGAGCCCAGGAGGTGGAGGCTGTAGAGAGCCATGCTTGGGCCACTTGCACTCCAGCCTGGGCAACAGAGCAAGACCCTATCTCTAAAAAAAAAATGGAATTGAGGATGTGTCCTCTCGGTGTGGGCTCTACCACCCACCAGCCTCCCTCTCCTGTGGGTCCTGCCTGCCACCCACCGCTGAGGTCCCTGCAGCATCAAGCTGCCCAAACGAAGACACTCTCCAGCTCTGACCCAGGCACCCATACAGAGCCCGCCAGACGCCTCTGCTGCTGCAGTTCTTAGAATCCAGAGCGCGTGGGGAATGTGAATTTGTGCTGCTGGAGCCAAACATCCCACCTCCAGGTTTTACCTGGAGGAATCCATGTGGATATGCAAAGCAATGTAGTTATAATGAATAGCAATTGTGGGCTGGCCGCAGTGGCTCATACCTGTAATCCCAGCACTTTGGGAGGCTGAGGTGGGTGGATCACCTGAGGTCAGGAGTTTGAGACCGGCCTGGCCAACATAATGAAACTCCGTCTCTACTAAAAATACAAAAAAATTAGCCGGGCATAGTGGCGGGTGCCTGTAATCCCAGCTACTCAGCAGGCTGAGGCAGGAGAATCACTTGAACCCACCAGGCAGAGGTTTCAGTGAGGCGAGATCGTGCCATTGCACTCCAGCCCGGGAGACACACCGAGACTCTCTTTCTCAAAAAAAGAATAGCAGCTTTCCTATAGCTTAGGGGAGCAAAACCCCAAAGCCACCTTAAGTTTCCCCAAGATAGAGATCCCTGGGGTCCTATTCTGAGACACAGTCTTGCTCTGTCGCCCAGGCTCGAGTGCAGTGGCCGATCTCAGCTCACTGCAGCCTCCGCCTCCTGGGTTCAAGCAATTCTCCTGCGTCAGCCTCCCGACCAGCTGGGATTACAGGCCCCCGGCACCACCCCCAGCTAATTTTTTTTTTTTTCAGACAGAGTCTCGCATTGTCCCCCAGGCTGGAGTGCAGTGGCGCGATCTTGGCTCACTGCAAGCTCCACCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCAGGGACTACAGGCGCCCGCCACCGTGCCCGGCTAATTTTTTTTTTTTCTATTATTAATAGAGACGGGTTTCACCGTGTTAGGATGATCTCGATCTCCTGACCTCGTGATCCGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCTTGCCTGGTCCTTTTTTTTGTATTTTTAGTAGAGATGAGGTTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCATGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACACGTGTGGGCCACTGTGCCCGGCCAGTCCCATTCTACTTTTTAGGGACATGGAATCATGTAAAGATGCCATACAGAAAACAGTATGCAAATCCAGAGACAGAGGACATCTGTGCATGTTTCTTTCTTTCTTCCTTTTTTTTTTTTTTTTTTTTTTTGAGATGGATTCTTGCTCTGTCGCCCAGGCTGGACTGCAGTGGTGCAATCTCACCTCACTGCAACCTCTGCCTCCCAGGTTCAAGTGATTCTCCTCCCTCAGACTTCCAAATAGCTGGGATTACAGGCATGCCCCACCATGCCCAGCTAATTTTTGTATTTTTAGTAGAGGCGGGGTTTCACCATGTTGGCAAGGCTGGTCTTGAACTCATGACCTCAGGTGATCCACCCGCCTCAGCTTCCCAAAGTGCTGGGATTACAGGCGTGAGCCGCCGTGGCAACCCGCATGCTTCTTATGTATAAGAAAAAAACAGCTAGAAAGTTGTGGGTTCACTGGCTGGGCACATGGTGGCTTGTGTCTGTAACCTCAGCACTTTGGGAGGCTGAGTTAGGAGGATCATGTGAGGCCGGGAGTTCAAGACCATCCTAGGCAACATAGCCAGACCCTGTCTGTACCAAATAGAAAAAAAAATTAACTTGATCTGGTGGTGTGTGCCTGTAGTCTCAGCTATTTGGGAGCCTGAGGTGGGAGGATCACTTCAGCCCAGGAAGTCGAGGCTACAGTGAGCTATGATTGTGCCACTGCACTCCAACCTGGGCAACAGAGCAAGACCCTGAATCAAAAAGAAAGAGATGTATTTGCCAACACAGGGGTGTTCTGCAGTGGGGTGGGAACGGGACGTGTAGGACTTCATAGTTTCCTTTTTTTTGTTTTAGAGACAGGGTTTAAAAAAAAATTTTTTTTTTTTTTTTGAGGCGGAATTTCATTCTTGTTGCCCAGGCTGGAGTGATCTCGGCTCACTGCCATCTCCGCCTCCCAGGTTGAAGTGATTCTCCTGCCTCAGCCTCACGCAATTTTGTATTTTTAGTAGAGACGGGGTGACTCCATCTTGGTCAGGCTGGTCTCAAACTCCCGACCTCGGGTGATCTGCCTGCCTTGGCCTCCCAAACTGCTGGGATTACAGGTGTGAGCCACTGTGCCTGGCCCCTTTTTTTTTTTTTTAAGTAGGGTCTTGCTAAGTTCTCCAGGCTGGTCTTGAACTCCTGGTCTCAAATGATCCTCCTGACTTGGCCTCCCAAAAGGCTCCGATTGCAGGAGATATGAGCCACCGCACCCGGCCCTTTTATAAGTTTTCTAAAGGAAAGGAACATGTACCATCGTCTTTTATTTTAATTTTTACATACAAGCAGGAACAATAGCATGAACCCCCAGACACGGCCCCCCAACATGCCCTGTTCCGCTGTGCTGCAGCCCCATTTGTCCTTTTCTATACCATTTTTGGTTGTATTTGAAGCAAATCCCTGACATCAGGGCATTTCATCCCAAAATACTTCCATCTGTGTTTCTAAAAAAACGAGGCCATTTTCTTATGTAACCACAACGTGATCAACAGTAATCAATGCTTAACATCTAATTCTGGGCCACGTTAAGACCCTCCTGATTGGCTCAAGAATGTCTTTTGTGCAGTTGGTTTCTTGATTCTTTTTGTTTTTTTTCAGACAGGCTCTCACTGTGTCACCCAGGCTCCAGTGCAGTGGTGCAATCACGGCTCACTGCAGCCTCAGCCTCCTGCCTCAGCGATCCTCCTGCCTCAGCCTCCCAACTAGCTGGGACCACAGGTTTGCACCACCACTCCCAGCTAATTAAAAAAAGTAATTTGTAGAGACGGGGGTGGGGTGGCGGTCTTGCTATGTTGCCCAGGCTGGTCTCAAACTCCTAGACTCAAACAATCCTCCTGCCTTGGCCTCCCAAAGTGTTGCGATCACAGGCATGAGCCCCTGTCCCTGGCCCCTATTATTTCTCTAACTGGCGAAAGTCATGTGGGAACACATGTAGCTTGCCTTGGCCTCTGACCGGCCCTGCCTGCGTTCCTGGGTGCTCTCTGCTGCTTCTCATGTGTGCCACTGTGGGGACTCGGCCGCCCACCCCACCCCGTGGTGTTACCTTGCGTGTGTAGTTCTGTGAGCTCAGGGCTATGGTCTGCCAGAACTAGGGGGCGTGGGGCCCCAGTACCAGCCCAAGGCCTCCTCTCTGCAGGTATGGACCTGTCTGCCAATCAGGACGAGGAGACCGACCAGGAGACCTTCCAGCTGCAGATCGACCGCGACACCAAAAACTGTGCCTTCCGTACCCACACGCGCAAGTACTGGACGCTGACGGCCACCGCGGGCGTGCAGTCCACCGCCTCCACCAAGTCAGTGCCTCGCTCCCACCTCTCACCGCCCCCACCACCTTGCCTGGGCTACCCCGCCTGACCCTGTCCCGCCATCCCCCAGGAATGCCAGCTGCTACTTTGACATCGAGTGGCGTGACCGGCGCATCACACTGAGGGCGTCCAATGGCAAGTTTGTGACCTCCAAGAAGAATGGCCACCTGGCCGCCTCGGTGGAGACAGCAGGTAACACTAAAGCCCCAGTTCCCTGGAGCCGTCCTGGAGTCCTGGAGGGTCTGGCCATGCCGTGGTCACTTGGTAGCCCCAGCCAAGGCCTGCTCTGTGCTGGGCATCCCCCCCGACTGGCCCCGCACTGTCCTACCCTGGGGCTCACTGCTGTGTGACCCCAGCTCCTGGCCCTCCCTCTCTGGTCACCCCAGCCTCCACCCCACTCCCTGCCAGGAGGCTCACTGACTCCCCTCTTTCTGCCACAGGGGACTCAGAGCTCTTCCTCATGAAGCTCATCAACCGCCCCATCATCGTGTTCCGCGGGGAGCATGGCTTCATCGGCTGCCGCAAGGTCACCGGCACCCTGGACGCCAACCGCTCCAGCTATGACGTCTTCCAGCTGGAGTTCAACGATGGCGCCTACAACATCAAAGGCAGGTTCTCCTGTGGGCAGCTGCTGGGCAGGGAACCCCTCGGTCGGCGCTGGGGTCAGTGCTGCCGGGAGCGCCCTCTGCATCCACACTGGACCCTGGCTTGGCTCAGGGCCATTCCAGGCCCTAAAGGGACACGTGTCTGATGGCCACCAGGGGCTCTGGGATGCAAGCAGCCCCTTTCCCTCTTGTCTGTGTGGTTCCGGGGACTTACCTTGCCCACCTGACAGAGAGGTGTGTGGAGGGGAGAGCAGGGACGGGAAGGAGAGCAGCGAAGGGGAGGGAGGACAGCAGGGGAGGGGAGAGCCGGGAAGGAGAGGAGAGCAGGGGTGGGGAGGTTCTGGAAAGGGTGTGCAGGGGAGGACGCGCCTCGGTTATGGGACTGGAGCCCCTTCCCAGGAGGACCCCCAACAATCCAGAGGTGCCTGTTAGGATTCAGAACATGCTTTTTTTGTTTGTTTTTTTGAGACTCACTCCCTCACCCTGGCTGGACTGCAGTGGCGTTATCTCGGCTCACTGCAACCTCTGCCTCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGTCTGCACCACCACGCCTCGCTAATTTTTATATTTTTAAAATTTATTATTTATTTATTTTGAGACCCAGTCTGCAGTGCAGTCGCGTTATCTCGGCTCTCTGCAACCTCTGCCTCCTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCCAGTAGCTGGGACTATGTGTGGCAGCCACCATGCCTGGCTAATTTTTTTGTATTTTTCATAGAGACGGGTTTCACCATGTTGTCCAGGCTGGTCTTGAATTCGTGGCCTCAAGTGATCCGCCCACCTCAGCCTCCCACAGTGCTGGGTTTATAGGTGTGAGCCACCACACCCGGCTAATTGTTTTGTATTTTTACTAGAGACGGAGCTTCACTATGTTGGCAAGGCTGGCTCGAACTCCTGACCTCAAGTGATCCGCCCACCTCACCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCGGCCCAGCAGAACACGTTCTAGGACCCTTGTTCATGTGTCCATCATGGACAGGAGGACGTGCGGGCCATAGGGACCCTGGCTCATTCCGGAGCCGGGACTGGAGGGTGGGGCGTCACCCTTGGGAACACCCCTGCCCACCCTCCGCTGCCCACGGTAGGGGTGGGGAGCCAGGCTTTGGCCCCCACTTGATAAAGTCCCCTCCCCAGACTCCACAGGCAAATACTGGACGCTCGGCAGTCACTCCGCGGTCACCACCAGCGGCGACACTCCTGTGGACTTCTTCTTCGAGTTCTGCGACTATAACAAGGTGGCCATCAAGGTGGGCGGGCGCTACCTGAAGGGCGACCACGCAGGCGTCCTGAAGGCCTCGGCGGAAACCGTGGACCCCGCCTCGCTCTGGGACTACTAGGGCCGGCCCGTCCTTCCCCGCCCCTGCCCACATGGCGGCTCCTGCCAACCCTCCCTCCTAACCCCTTCTCCGCCAGGTGGGCTCCAGGGCGGGAGGCAAGCCCCCTTGCCTTTCAAACTGGAAACCCCAGAGAAAACGGTGCCCCCACCTGTCGCCCCTATGGACTCCCCACTCTCCCCTCCGCCCGGGTTCCCTACTCCCCTCGGGTCAGCGGCTGCGGCCTGGCCCTGGGAGGGATTTCAGATGCCCCTGCCCTCTTGTCTGCCACGGGGCGAGTCTGGCACCTCTTTCTTCTGACCTCAGACGGCTCTGAGCCTTATTTCTCTGGAAGCGGCTAAGGGACGGTTGGGGGCTGGGAGCCCTGGGCGTGTAGTGTAACTGGAATCTTTTGCCTCTCCCAGCCACCTCCTCCCAGCCCCCCAGGAGAGCTGGGCACATGTCCCAAGCCTCTCAGTGGCCCTCCCTGGTGCACTCTCCCCGAAACCCCTGCTTGGGAAGGGAAGCTGTCGGGTGGGCTAGGACTGACCCTTGTGGTGTTTTTTTGGGTGGTGGCTGGAAACAGCCCCTCTCCCACGTGGCAGAGGCTCACCCTCCCTCCCTTCCCTCGAGCGGCAGGCCCTGACGGCCACAGGGTCTGCCCCCTGCACCTTCTGCCAAGGTGGTCGTGGCGGGCGGGTAGGGGTGTGGGGGCCGTCTTCCTCCTGTCTCTTTCCTTTCACCCTAGCCTGACTGGAAGCAGAAAATGACCAAATCAGTATTTTTTTTAATGAAATATTATTGCTGGAGGCGTCCCAGGCAAGCCTGGCTGTAGTAGCGAGTGATCTGGCGGGGGGCGTCTCAGCACCCTCCCCAGGGGGTGCATCTCAGCCCCCTCTTTCCGTCCTTCCCGTCCAGCCCCAGCCCTGCGCCTCGCCTGCCGACACCTGGGCCAGAGCCCCTGCTGTGATTGGTGCTCCCTGGGCCTCCCGCCTCGATGAAGCCAGGCGTCCCCCCCTCCCCCAGCCCTGGGGTGAGCCCCCCCGGCCCCCCTCCTGCCAGCCTCCCCCGTCCCCAACATCCATCTCACTCTGGGTGTCTTGGTCTTTTATTTTTTGTAAGTGTCATTTGTATAACTCTAAACGCCCATGATAGTAGCTTCAAACTGGAAATAGCGAAATAAAATAACTCAGTCTGCAGCCCCAGGCCGGCCTCTCTGTGTCTTCGGGCTGACGTGGGTGGGCGGGCTGAGGTCGCTGGGAGGGCTGGCGGGACAGGTAGGCGCCCTGCCTCCCCAGCTCAGTGCTGGGAGTGTGCAGTGGGACGGAGGCCGTGGCTCCAGTGGGTGCTCCGGACCTCGTGGGCCCAGCACACCTCCTTAAGCGGCCCATCGAGCGCTGGGAGGGGGTGGACTGTGGCCCATGCCACCCCCAGAGCCATTAGGAGGAGTTCTGTGGTGAGAAGTGGCTGTGGCTCCTCGTAGGCTACGTCCACCATGCGGGGGACCTCGGGGGTGTCTGGCGGTGGCACGCTGGATGTTGAGAAGGCGCAGCCCAGGGAACACTCAAACCAGGAGACCCCACATTATCCTCTAGTTCACATGTGCCCTTCGACTAGGGGACTTGGTGGTAGGGCCAGCTCCGCCCCCATACTGCGAGGATCCGGGCCTTCCACTTCCCCAGACACAGCAGGTTGGGGTGCCCCTGGGGCTGGGAGATGCTGCCCTGGGCCCCTCAGCCGGCGGCCGTGGTAGGATGGACCGGGCCGAGCCTCCAGACCCTGGCCAGGTCCCTACATCGGAACCACCAGCCCTGGCGATATCTGGCATATCAGAGGCTCAGGACTGTTTCCAGACTTTACCAAGGCCACAGTCAGCGCGACCTGGGTTCTGAGCCTCCCTTTGCATCCTAGGCTGCAGGGACAGGGGCTGGGCAGAGGCTCGCGGACCTCGTCGAGCTTCATTCACTCCCAGGTGCCCCTAAGGATAGCAGCTGCGAGAAGACTGAGGGGAGGAGCAGTAAGGCGCAGCCTGGAGCGGAGGGACCTGGCGTCCAGTCATTGTGCGCTGGGAAGGCGGTGATGGCCACGGAATTTGGGACACGCGGGGCGTCCCGGGGGCACCCAGGGCACTGCAGGCCGGAGCCCCCTGTTCCCCCGCATCCTCCCCGCCGTCGGCAGCAGAGCAACCGCTGATTGGCTGCTGATGACGCAACTGGGAGGGCTGCGCTGTGATAGGTGGTCCCTCGGGGGCGTGGGGCCCAAGTCTTGAGATTGGCAGGGGCAGGTGGCTGCTGCAGAGGGAAGTCGGGGTCACCTCAGCGAGGTTCCGGCGGCCACCCCTCTCCCCTCCCCCATGAAAGCCAGGCTGGAAGCCAGAAAAATCCCAGTGACTGGAAGGGACAGATTAATCCTCCGGAACCAAACTCTTTGAGACCTGGGGAGGAGGGTGGGAGGCACTGGGAAGGGGGATTGGGGGGAGCCTGGCTCATTTCCACCCATGGAGCTGACCTAGAATGACCCTAAGGTCCCCGGACCCACCAGCTGATTCCGAATTCCATTCATTCTGCAAAATTTGGCGCCTACCACGTGGCCGACATTCCCGAGGCTGCAGCCAATGAGCAGCATAGTCCGATGCGGGAGGCTGGAAGGGCCGTTCACGAGATCTCTCGGGAGGAATCGGTAGGAGCTGCCCAACTGAAAGGGACGGGGGAATAACCCGGGGCGAGGGACCTGCCCACCCCCTGCCCTCTGGGGGGAAGCCAGGCCAGCGGCCGGGGGCATCTCTGGGGTCCCAGGTGAGATGCGCGTCGAGGGAGCCAGGCCACGGTTCTCCAGACTCGCGTGGAGGCCACGAGCGTCTTCTGGAGGAGCGGCCACTGCGCGGACCGGCAGACTCTGGGGCGCTCGTGCTCCCCATCTCCTGACCTTTTCCTACCTTCAGTTCCCTCCTGTCAGGACAGGTTCTGGGGCTCGCCGCGGCAGGGAGCCAGGGCAGAGGGTGCAGTTTCCGCTCCTGCCTGAGTCACCTTCGCTTTCTCAGCGATTCTTCATTCACAAGGGCGTGGCCCATCACACGCACTCACACACTTGTGAACTTGCACGCACACACACATATCGACCTGTGCAAAGAGCCCCATGCACACCCAGGTACACGTGCATGTAGGCGTGCACACAGACACGCACAGATGCAGGCAGACCAACTCCCAGGAATCTGTCTCCAGCCTACAGGGATTCAGCACTCAGGGTACCAGCCTCTGTCCCGTGCACCCCCATTCCCGGCAGTTCTCCCAGGTGGGTCGGGGGCCACTAGGGACCCCATACCCCGAGGGTGGCTCCTCCATTAAGCCTGCCATGGGGTTGGGAGTGAGAGTCCCACCTCCCACTTCAGAGTCCCCAGTGAGTCAAGGCAAGTGCAGCCAGGGCTCCAAGATCCTTGTTGGGATTCACTGTGATCCCCAAAGATCACGACTTAAGGGAAAACATTCAATTAAACTTGTTAGAGCAAAGAAAGGAGAGACTGGGCTGGGAGCAGTGGCTAACGCCTATATAGTTCAGCTACTCAGGAGGCCCAGGTGTGAGGATTGCTTGAGTCCAGGAGGCTGAGGCTGCAGTGAGCTATGATGGCACCACCCACTGCACTCCAGCCTGGGTGACAAAGCAAGACCCTGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAAAGGAAAAAGAGGCCGGGCACAGTGGCTCACACCTGTAATCTACTAAAAATAAGAAAATTAGCCAGACATGGTGGTGGGTGCCTGTAATCTCAGCTACTTGGGAGGCTGGGGCAGCAGAATCGCTTGAACCCACGAGGCGGAGGTTGTGTGAGCCGACATTACACCACTGCACTCCAGCCTGGGCGACAGAGTGAGACTCTGTCTCCAAATAATAATAATAATAATAATAAAATAAAAAGAAAAAAGAAAGAAAGAAAGGAGAGACTGAGCTATATTGCCCAGTCCAGGCATGTCGGCAGTCTGGGCGACAGTGGGGCATACTCGCTGTCTCAGGGTCCCAGCCCTGGGTGCCCCCACTGCTCTCTGCTGTGACCTCCTCAGGAGGCCTCATTGGGAGGGACCCTGAGTCCTGCGGGGGGCTGTGGAGCTGTCACCAGCCCCAGGAGGACTCAGGCAAGTCCCTCTCGTCGTCGAGGCCTCTGAGCTTCCCAGTGTGTCTCCACCGGACACCCCCCCTCCAGACCTTCTGCCCCAGCTCAGCCTCTTCCAATTCATTATCAGGGGGTGGGCGAGGGGACAGGAAGCCCCAGACCCAGCTGCCCCCCATTTCCTCCAGGGCCACAGTGGCCTCTCCCAGACTCACGAGGATGGGGGCTGATCTCACTCTTTTTTTTTTTTGAGACGGACTCTCACTCTGTCGCTTTTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTCACTCTGTCCCCCAGGCTGGAGCGCAGTGGCGTGATCTCGGCTCACTGCAATCTCCACCTCCCACGTTCAAGCCATTCTCCTGCCTCAGCCTCCTGAGTAGCTGCGACTACAGCTACGTGCCACCACACCTAACTAATTTTTGTATTTTTTAGTAGAGATGGGGCTTCACCATATTACCCTCCCAAAGTGCTGGGATTACAGGCATCAGCCACCATGCCCGGCCTTGACTTCACTCTTTTAAAAAAGTCAAATACTTGGTGCTTGAAATCCCAGCACTTTGGCAGGCTGAGGCAGGAGAACTGCTTGAGCTCAGGAGTTTGAGACCAGCCTGGGCAACATGGTGAGACTCCTGTCTCTGTAAAAACTACGAAAATTAGTCAGGCATGGTGGTGCGTGTCTGTCGTCCCAGCTGCTCAGGAGGCTGAGGTGGGAGGATGGTTTGATCCTGGAAGCTTGAGACTGCAGTGAGCTGTGATTCCACCACTGCAGTCCAGCCTGGGCCGCAGAGCAAGACTCTCTCTCAAAAATAAATAAAATAAAATAAAAAGTCTAAAACTTTTCTTTCAAACGACGGCTTTTGGGGCTCATAAGGTGCGTGAAGATGGAAAGGGGGCCCGGCAGTGCCCATTTCGGCTCCCTTGGGACCCCGGCTTCCCTGAAGACCCCTGAGCAATGGTTGGCTGGGTGCCTGGTCTCCCTGAACGGGCTGTGGGCAACAAGGTTGTCTGGATGGGGGAGGGGCTCTGAGACCCTTGGGGGCAGCAGAGGGAGAAGGGAACAGATGGGGTCTCCCAGGCAGAGAGGCCTGGAGGGGTGGGGCGGGGCAGGGCATTTGGCGTGAAACCCAAGCCCCTTAACCGGGCCCTAGCTTAAACCGGGAGGAGGGGCCTCTGTGATGTGCAAATAATTAACACAGAAGCCTTCACTGTGCTCCCCTCCTCATCCCAGGACCCAGGTCTGACCCTCAGGAGGGGAGGAGGTGAGCAAGGGGGGAACCCACCTTCCAGGGAACCCCCAGATAGTCCCAGGCACCAGGCAAGTGCTCTAAAAGGCTTTACTAATATTATTTGAAGAAACTAAGCTAATAAATAAATACGGTATAAAATCAAAGGGTACCCACAGATATAAACAAAAATCCACAGCTAACCCGGCCCCAGCCCTCTTTCCTTTGGAGGTAACTGTGTTAATCGTTTTTTACACCCCTCTGGAATTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTGGGAAGGAGTCTGGCTCTGTCGCCCATGCAGCGCAGTAGCGTGATCTCGGCTCACTGCAACTTCCACATCCCGGGTTAAAACGATTCTCCTGCCTCAACCGCCTGAGTAGCTGGGACTACACGGGCGCACCACCATGCCCGGCTAATTTTTTTTTTTTTTTTTTTTTTTTTTGAGCTGGAGTCTTGCTCTGTCGCCCAGGCGGGAGTGCAGTGGCGCAATCTCGGCTCACTTGCAAGCTCTGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCTGAGTGGGTGGGACTACAGGCTCCAGCCACCACGCCCGGCTAATTTTTTGTATTTATTTTTTAATAGAGATGGGGTTTCACTGTGTTCGCCAGGATGGTCTCGATCTCCCTTTTTTTTTTTTTTTTTTTAGACGGAGTCTCGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCATGATCGTGACTCACTGCAAACTCCACCTCCCGGGTTCACGCCATTCTCCCGCCTCAGCCTCCCGACTAGCTGGGACTACAGGCGCCCACCACCACACCCGGCTATTTTTTTGTATTTTTAGTAGAGACAGCGGTTTCACCATGTTAGCCAGGATGGTCTCGATCTCCTGACCTTGTCATCCTCCTGCCTCGGCCTCCCCAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCCCGGCCTCTTGTTTTTTTTTTTTTTTTTTTTTATAGACTTCTAAGGAAAGCAACACTAAGAAAATATATTTTTAAGAAATTATTCAGCCAGGCGTGGTGGCTCACGCCTGTAATCCCAACACTTTGGGAGGCTGAGGCGCCTCCATCACTTGAGGCCAGGAGTTTGAGACCAGCCTGGCTCACATGGTGAAACCCTGACTCTACTAAAAATACAAAAAATTAGCCGGGCACAGTGGCATGCTCCTGCAATGCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCCCTTGAACTGGGGAGGCAGAGGTTTCAGTGAACCAACATCGACCCACTGCACTCCAGCGTGGGTGACAGACTGAAACTGTCTCTCAAAAAAAAATTTTTCTTTTTGGAGATGGGGTCTTGCTCTGTCACCCAGGCTGGAGTACAATGGGGTGATCTAGGCTCACTGCAACCTCAAACTCCTGGCCTCAGGTGATCTTCCTGCCTCACCCCCTGCAGTAACTGGCACTACAGGTGCATGTCAGAACACCTGGCTAGTTTTTAACTTTTTTGTCTGTAGACAGGGTCTTGATATGTTGCCCAGGCTGGTCTCCATCACCTTCTGGGCTCAGTGATCCTCCTGCTTCAGCCTCCCAAAATGCTGGGATTACAGGTGTGAGCCACCATGCCCGACCCTGAGGGATACCTTAATGTTTATTTCTCACATTTCTTCTAGAACAAACATTGCCAGCGCATCCCAGACTCTGAACTGTGGCTCCCGACTGCAGCATGGAGGTCTTTCCAGGCACTCTGGGAAACATGCCACAAGCAGGGTATTAACCCAAGACAGTCAGTCCCTCCAATGAGAAAAAGGAGCCGAGGGACTGTGCATGCCTCAGAGCCACATGCAGCAGAACTGGTGGGTTGAGGCGGCACTGAGCGCCTGGTGCCTCCTGCTGCCCCCCACCAGCTCCCACAGTCCTCGTCCTTGTCCTCCCCATCAGAAGGGAAGAGTGAATTGTCTGTGGCATGTGCCAGTGTCCCCCGTTCTGAGGTTGGGCAGGCTGGGGAGCCCCACACATGGCTTGCTGCCCACTCTGCAGCCTCCTGGACTTAGTTCCAGGCTCTGCCCGATCCTCTGAGGGTGTGGCTTCAAAGCCCTGCTTGGGCCTAAGGCCATCCCAGGGCAGTGACTGACGGTACACTGAGATGTCCCTTGCGCACCAGTCCTAGGGTACCTGGGCTGGGGGTCTTCAGCTCAGGCCCCCTAGTGCCCGTCCTTTGGGCTGTGCGCAGGTTTCCACAGCACTGGCCCTTTCTGACCTTACACCCCTGTGCATCCTCACTGCCCCTCTGTGAAGGTGAAAGTCACACTAAGGACTGTGCCTATGCTGGCCAGGGCACCCCACCGGCAGCACACCTCAGACGCCTCATCCTAGGCGCTCCTCACTTTTTTTTCTTTTTTTTCCTTTTTTTTTTTTTTTTTTTTTCCCAGACACAGTCTTGCTCTGTCACCTACGCTCGAGTGCAGTGGCATGATCTCGCCTCACTGCGACCTCCTCCTCCTCCTGGGTTTAAGCAATTCTCTTCCCTCAGCCTCCTGAGTAGCTGGCATTACAGCTGCCCGCCACCACGCCCGGCTATTTTTGTAGTTTTAGTAGAGACCGGGTTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCTGACCTTGTGCTCTGCCCCCCTTGGCCTCCCAAACTGCTGGGATTACAGGCGTGAGCCACTCTGCGTGGCCCTGCTCATTTTCTTACCACAGCTTTCCAGAAATAAAGTTAGGATCGAAAGAGAGAGAGAGAGATTGAGAGAGAGAGAGAGCACCACATTCAGATAGAGACAGGAGAGTTCTCAGCAAGAAGAGAACTCAGCTCAGAGTTGAGAATGTCTCAACTCAGCTGTCTCCCTCCTGACACGTCCTGGGCTGAAGTGTCCCCTCACCCCTGCGGGGCTGTGACTCCACACTCCACACATGGGTCACAGCAGGGCTTGGCGTTTGGAGCAGGCCGGGTTGGTGGCTTGTCCTCATCTCTTGCCTGCAGCTGTGCTGGCCTGTGGTTTGCTTTGGCTGCTACCATGTCCAGGGAGAGGTGCTTGTGTCCATGCCTGGCCTCTTGGAAGGCCACCACTGTGATCGACAGAGGAAGGCCACCACTGTCATGGAGAGAAGCCGGGGCCAGACCGATGAGCGCTGAGAGCCCATGGGCAGCGCTTGTCGTCTCGGCCAAACCCCAGCTGGCAGCTGATGGCAGCCACCCCGGGGTCCTCAGATATGGCACAGCTGCCTGGCTGAGCCTCGGCAAAGGGAAGCCTTGTGGAAAATAGCAACTCAGGGATGTTGTGAGTAGTGGGCTGAGCTGTGGTTTATTTTTTAGAGACACGGTCTTGCTCTGTCACCCAGGCTAGAGTCCAGTGGTGTAATCATAGCTCACTGCAGCCTTGACCCCCCAGGCTCAAGTGATCCTTGTGTCTTGGCCTCCTGAGTAGCTACGACTATAGGTGCATACCACCATGCCTCGCTTGTTTTTTGTTTTGATAGAGATGGGGGTCTTGCTAGGTTGCCCAGGCTGGTCTGTAACTCCTGGGCTCAAGTGATCCTCCTGCTTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGTGCTGGCCTTGGGGTGTGGTTTTATGTGGCCATAGATGACTGAGATGGGTGAGAAGCGGGACCTAGGGGAATATACAGGGCAGCGGGATCCGACAGGGGGACAGGAGGGCAGACAGCTCCTGGAAGGCCTGGGAAAGAGATATCAGGGCTGGACCCTGGAGAAGTGAGGCTTTGAGCGAGGGGAGGAGATGGGGCCTGGCGGGGTACGGGCGCTGCTCCTAGGTCTGAGGGCATCGGCGGTCTGAGAGCTTCCGGGAGGGAGGGCTGCCTCCCGGTGCTCGGTGCCCTGGCTCTCCTCCTTGCTGCTGGCTGGCCTCCTCCTCCTCATCCATCTGTGTGTCCTGGAACACAGGGCACTGTCCCTCTGCCTGTCCAGAAAAGCACGTGCTCCTTGGGGCCTGGCCTGCTCAGCCCTATGTCCCACCCCCTCCCTGCTCCTATTCCCAGGCCTTCGGGCCTCACTGCCTGGGGTGGCCGTGCTCAGCCCCACCCTGTGGTGCCATGGCCTCCCCACCCCTGCCCCGAACTGCCCCTGGGACCAGTTCCTTCAGCTCCCAGGACAGGGCCTGGCCATCCCTGTGGATTCTCCCTGTTCGTGGACCCCCATTGGTGCCCAGTCTCCTTGGACTGTCTTCTGAGCCTCTCTCAGATGTACCCCCAACTGTACCCTTTCACCCAGAGGCCATTTGGCAGCGTCCTCCAGGACTCCTGCCGTGGGGGAAGTCTCCACCAAGGCCAACGCGTGACTGCATCCCGAGGAGCTGATTTAAGATCTGGTTCTCAGCAACACCTGGAACTGGCCAGTCAGCATCCCCGGCCCTGCGGTCTGCACTTGGACAAGGGTCAGGCAATGAGGATGAGCAGCAGGCGGGGCTTCTCCTGGAAGCCTTCCCAGCCTCCTGGGCCACTCCAGTGGGTCCCCTCCACAGACTCAGCCTGTTCCCTGCCACCTGGTGCCGGTTTCTCTGTGGCACCTACTAGGGGCCGACTGCCCCGGGACTGCCCAGCTGAGCAGCGCCGTCCAGGTCTGCACCCAGCTACACTCAGGGCACGTGCACAGGTGAGCAGCCGGGCACGCAGGCACCTGCCAGGTGTGGGTGTGGACTACGTGCTCCCGG HUMAN SEQUENCE - mRNA (SEQ ID NO: 5)GCGGAGGGTGCCTGCGGGCCGCGGCAGCCGAACAAACCAGCAGGGGCGCCGCCGCAGGGACCCGCCACCCACCTCCCGGGGCCGCGCAGCGGCCTCTCGTCTACTGCCACCATGACCGCCAACGGCACAGCCGACCCGGTGCAGATCCAGTTCGGCCTCATCAACTGCGGCAACAAGTACCTGACGGCCGAGGCGTTCGGGTTCAAGGTGAACGCGTCCGCCAGCAGCCTGAAGAAGAAGCAGATCTGGACGCTGGAGCAGCCCCCTGACGAGGCGGGCACCCCGGCCGTGTGCCTGCGCAGCCACCTGGGCCGCTACCTGGCGGCGGACAAGGACGGCAACGTGACCTGCGAGCGCGAGGTGCCCGGTCCCGACTGCCGTTTCCTCATCGTGGCGCACGACGACGGTCCCTGGTCGCTGCAGTCCGAGGCGCACCCGCGCTACTTCGGCGGCACCCAGGACCGCCTGTCCTGCTTCGCCCACACGGTGTCCCCCGCCGAGAAGTGGAGCGTGCACATCGCCATGCACCCTCAGGTCAACATCTACAGTGTCACCCGTAAGCGCTACGCGCACCTGAGCGCGCGGCCGGCCGACGAGATCGCCGTGGACCGCGACGTGCCCTGGGGCGTCGACTCGCTCATCACCCTCGCCTTCCAGGACCAGCGCTACAGCGTGCAGACCCCCGACCACCGCTTCCTGCGCCACGACGGGCGCCTGGTGGCGCGCCCCGAGCCGGCCACTGGCTACACGCTGGAGTTCCGCTCCGGCAAGGTGGCCTTCCGCGACTGCGACGGCCGTTACCTCGCGCCGTCGGGGCCCAGCGGCACGCTCAAGGCGGGCAAGGCCACCAAGGTGGGCAAGGACGAGCTCTTTGCTCTGGAGCAGAGCTGCGCCCAGGTCGTGCTGCAGGCGGCCAACGAGAGGAACGTGTCCACGCGCCAGGGTATGGACCTCTCTGCCAATCAGGACGAGGACACCGACCAGCAGACCTTCCAGCTGGACATCGACCGCGACACCAAAAAGTGTGCCTTCCGTACCCACACGGGCAAGTACTGGACGCTGACGGCCACCCGCGGCGTGCAGTCCACCGCCTCCAGCAAGAATGCCAGCTGCTACTTTGACATCGAGTGGCGTGACCGGCGCATCACACTGAGCGCGTCCAATGGCAAGTTTGTGACCTCCAAGAAGAATGGGCAGCTGGCCGCCTCCGTGGAGACAGCAGGGGACTCAGAGCTCTTCCTCATGAAGCTCATCAACCGCCCCATCATCGTGTTCCGCGGGGAGCATGGCTTCATCGGCTGCCGCAAGGTCACGGGCACCCTGGACGCCAACCGCTCCAGCTATGACGTCTTCCAGCTGGAGTTCAACGATGGCGCCTACAACATCAAAGACTCCACAGGCAAATACTGGACGGTGGGCAGTGACTCCGCGGTCACCAGCAGCGGCGACACTCCTGTGGACTTCTTCTTCGAGTTCTGCGACTATAACAAGGTGGCCATCAAGGTGGGCGGGCGCTACCTGAAGGGCGACCACGCAGGCGTCCTGAAGGCCTCGGCGGAAACCGTGGACCCCGCCTCGCTCTGGGAGTACTAGGGCCGGCCCGTCCTTCCCCGCCCCTGCCCACATGGCGGCTCCTGCCAACCCTCCCTGCTAACCCCTTCTCCGCCAGGTGGGCTCCAGGGCGGGAGGCAAGCCCCCTTGCCTTTCAAACTGGAAACCCCAGAGAAAACGGTCCCCCCACCTGTCGCCCCTATGGACTCCCCACTCTCCCCTCCGCCCGGGTTCCCTACTCCCCTCGGGTCAGCGGCTGCGGCCTGGCCCTGGGAGGCATTTCAGATGCCCCTGCCCTCTTGTCTGCCACGGGCCGAGTCTGGCACCTCTTTCTTCTGACCTCAGACGCCTCTGAGCCTTATTTCTCTGGAAGCGGCTAAGGGACGGTTGGGGGCTGGGAGCCCTGGGCGTGTAGTGTAACTGCAATCTTTTGCCTCTCCCAGCCACCTCCTCCCAGCCCCCCAGGAGAGCTGCGCACATGTCCCAAGCCTGTCAGTGGCCCTCCCTGGTGCACTGTCCCCGAAACCCCTGCTTGGGAAGGGAAGCTGTCGGGACGGCTAGGACTGACCCTTGTGGTCTTTTTTTGGGTGGTCCCTGGAAACAGCCCCTCTCCCACCTGGGAGAGGCTCAGCCTGGCTCCCTTCCCTGGAGCGGCAGGCCGTGACGGCCACAGGGTCTGCCCGCTGCACGTTCTGCCAAGGTCCTGGTGGCGGGCGGGTAGGCGTGTGGGGGCCGTCTTCCTCCTGTCTCTTTCCTTTCACCCTAGCCTGACTGGAAGCAGAAAATGACCAAATCAGTATTTTTTTTAATGAAATATTATTGCTGGACGCGTCCCAGGCAAGCCTGGCTGTAGTAGCGAGTGATCTGGCGGGGGGCGTCTCAGCACCCTCCCCAGCGGGTGCATCTCAGCCCCCTCTTTCCGTCCTTCCCGTCCAGCCCCAGCCCTGGGCCTGGGCTGCCGACACCTGGGCCAGAGCCCCTGCTGTGATTGGTGCTCCCTGGGCCTCCCGGGTGGATGAAGCCAGGCGTCGCCCCCTCCGGGAGCCCTGGGGTGAGCCCCCCGCCCCCCCCTGCTGCCAGCCTCCCCCGTCCCCAACATCCATCTCACTCTGGGTCTCTTGGTCTTTTATTTTTTGTAAGTGTCATTTGTATAACTCTAAACGCCCATGATAGTAGCTTCAAACTGGAAATAGCGAAATAAAATAACTCAGTCTGC HUMAN SEQUENCE - CODING (SEQ ID NO: 6)ATGACCGCCAACGGCACAGCCGAGGCGGTGCAGATCCAGTTCGGCCTCATCAACTGCGGCAACAAGTACCTGACGGCCGAGGCGTTCGGGTTCAAGGTCAACGCGTCCGCCAGCAGCCTGAAGAACAAGCAGATCTGGACGCTGGAGCAGCCCCCTGACGAGGCGGGCAGCGCGGCCGTGTGCCTGCGCAGCCACCTGGCCCGCTACCTGGCGGCGGACAAGGACCGCAACGTGACCTGCGAGCGCGAGCTGCCCCGTCCCGACTGCCGTTTCCTCATCGTGGCGCACGACGACGGTCGCTGCTCGCTGCAGTCCGAGGCGCACCGCCGCTACTTCGGCGGCACCGAGGACCGCCTGTCCTGCTTCGCGCAGACGGTGTCCCCCGCCGAGAAGTGCAGCGTGCACATCGCCATGCACCCTCAGGTCAACATCTACAGTGTCACCCCTAAGCGCTACGCGCACCTGAGCGCGCGGCCGGCCGACGAGATCGCCGTGGACCGCGACGTGCCCTGGGGCGTCGACTCGCTCATCACCCTCGCCTTCCAGGACCAGCGCTACAGCGTGCAGACCGCCGACCACCGCTTCCTGCGCCACGACGGGCGCCTGGTGGCGCGCCCCGAGCCGGCCACTGGCTACACGCTGGAGTTCCGCTCCGGCAAGGTGGCCTTCCGCGACTGCGAGGGCCGTTACCTGGCGCCGTCGGGGCCCAGCGGCACGCTCAAGGCGGGCAAGGCCACCAAGGTGGGCAAGGACGAGCTCTTTGCTCTGGAGCAGAGCTGCGCCCAGGTCGTGCTGCAGGCGGCCAACGAGAGGAACGTGTCCACGCGCCAGGGTATGGACCTGTCTGCCAATCAGGACGAGGAGACCGACCAGGAGACCTTCCAGCTGGAGATCGACCGCGACACCAAAAAGTGTGCCTTCCGTACCCACACGGGCAAGTACTGGACGCTCACGGCCACCGGGGGCGTGCAGTCCACCGCCTCCAGCAAGAATGCCAGCTGCTACTTTGACATCGAGTGGCGTGACCGGCGCATCACACTGACGGCGTCCAATGGCAAGTTTGTGACCTCCAAGAAGAATGGGCAGCTGGCCGCCTCGGTGGAGACAGCAGGGGACTCAGAGCTCTTCCTCATGAAGCTCATCAACCGCCCCATCATCGTGTTCCGCGGGGAGCATGGCTTCATCGGCTGCCGCAAGGTCACGGGCACCCTGGACGCCAACCGCTCCAGCTATGACGTCTTCCAGCTGGAGTTCAACGATGGCGCCTACAACATCAAAGACTCCACAGGCAAATACTGGACGGTGGGCAGTGACTCCGCGCTCACCAGCAGCGGCGACACTCCTGTGGACTTCTTCTTCGAGTTCTGCGACTATAACAAGGTGGCCATCAAGGTGGGCGGGCGCTACCTGAAGGGCGACCACGCAGGCGTCCTGAAGGCCTCGGCGGAAACCGTGGACCCCGCCTCGCTCTGGGAGTACTAG

[0331] TABLE 2 (mouse gene Fosb; human gene FOSB) Mouse genomic sequence(SEQ ID NO: 7) Mouse mRNA sequence (SEQ ID NO: 8) Mouse coding sequence(SEQ ID NO: 9) Human genomic sequence (SEQ ID NO: 10) Human mRNAsequence (SEQ ID NO: 11) Human coding sequence (SEQ ID NO: 12) MOUSESEQUENCE - GENOMIC (SEQ ID NO: 7)CTCACTCCGCCAGTCTGAAGCATCCGGGCTCTGTCTGTGAAACAGTCCGCGAACTGGGAGGGTCTACCCACTGGCCCCAGCACCCCTCCTCCCAAGGCCCCCCATGCTGCTGCTTCATGTGACCAGGGCTGGGCCGAATCTCTGAGCAGACAGAGAGAAGCATGGTGTGACCGCATGAGTGGAGTGAGTTCTGGGGACAGTGCCCAGTTGTGCGATAGACAGCAGATTCCGGAGGACCACTGTGCATGTGTGTGTGTTGTTGTATTTGGTTTGTGTTTGTGAGTATGTCTGTGTGTGTGTGTGTGTGTGAGAGAGAGAGAGAGAGAGAGAGAGAGAGACAGACAGACAGACAGAGACAGAGACAGAGACAAAGAGAGTTGTGTGAGGACCACTGTGCATGTGTGTGTGTTGTGTGAATGTTTGTGAGTGTGTGTGTTGTTGTATTTGGTTTGTGTTTGTGAGTGTATCTGTGTGTGTGAGAGAGAGACAGAGAGACAGAGAGAGAGAGAGAGAGAGAGAGACAGACAGACAGACAGACAGACAGAGAGACAGACAGAGAGAGACAGAGAGAGACAGAGAGAGAGAGAGAGTTGTGTGAGGGCCTCCCAGGTGATCTGGGAAGCTTGTGAATGTGAAAGTGCCTGTGGGTGGCTTCACCTCTGGCAGAGGCATTCTGCCTCCTGTATATTAACTATGTGTGCTCAGACAATCCACTCAAAGATGCTCTGGGGCTGCAGCTGATAGAGCAGCTTACTTAGTGTGCACAAGGCCGTGGGTGCAAACACCCCAGAACTACAATCCCAGAACTCTCTCTGCGCACTGAACTCGACTTCCTCATTTGTTTCTTGTTTCTTTTTTTTGACGGAGTCTAACATTGTCCGGATTGCTTCAAACTTTATAGCGGAGGAAGATCGATGGCAATTCTTCTGCCTCCACCTTCTGAGTGCTAGGATTGCAGGCATGTACCCTCATGCCCAGTTGAGACAGTATCAGTGATTGAACCCAGGGCCTCACGCCTCCTGGAGAAGCCCTGTACCATGGAGCTACAAGTCTAGTTCCTTTTCTTGTCCTTAAAAAAAATAAAAAGCTGGGTCTTCTTATAGCCCAGCCTGGCTTTGTACTCCCCATCCTCCTGCCTCAGCCTCCCAAGTGCTGGGATGATAGGCTTATGGCACGGCCATGATAGCACCTACAATTTCCAGAGTTGCCTGTCCTTTGCAGTGTACTATGCCTTGTGAGGGACAGGCTCTGAGCGTCTGCTTGTGATCACACACCTGAGCACCTGTTTGCTGGGAGTTCTGTCCCCATTTCTTTGCCAGGCTGGAAGACACTGACACACCCACCATGGTGACAGTACCCATGGACTTAAATGGTGTGACTCCCTCTGCTCTAATGGGAGGGTCTCAGTGCCCCGTATCTGCTGTTTCTCAAATGGGGTAGGTAATACAGAGATAGGAGGGCTGACACAAAACATATCAAACACCAAGATAGCAAAGGCTAGAATGAGACCCTGTCTCAAGCTTTCCCATAGAGAAGGGGAGTGTATAATTGCACCCACTCACAAGACTGTTGGCCATAAACAAGTTTGTATGGAAAATGTTTACAAAGTGCTTGGCACATCCAGGGGTGGTGGCGCACACCTGGATTCTCATACTTGGAGAGAAGAGCCAGGAAGATTAGGGACGGTTCCAGTCAGGCCTACATATTGAGACCTTATCTCAAAAACAAAACAACACAACACACACACACACACACACACACACACACACCTCAAAAACCTCTGGAAGTTCACATTTTGGGAAAGGCATCTGAATGGTAAAGTGTAGGGATTAAGAGTAGAGACTAGAGTCCCTCCATGGGACCGAGATGTAGAAAAGAAAGAAAAGAGAGCTTGCTAAAGCAGGCCAGCCTAAGGGCAGACTCCTGAAAGGACTTGCTCCAAATGATTGTTGAGGGTGGAGGACTCTAAGAAACTGGAATTGTGGGAAAAACTCTCGGGGAATGACAAAAGCCGGTTTGCAGGTTGGTGAGATTAGAAAGTAATGGCCACAATATAGGGCACAATATACAGGCTGGTCTTGAACTTGTAATCCTCCTGCCTCAACCTCCCAACTATTATAGGTATATGTCACCAGCTGGATGCTTTTGCCTGTCTTGTTTCTTTCTGTGCCCCAGGGCTTCAGTGAATAGGGATGGCTGCCGATTAAATAACTGAATTGCTAGCAGGGTGGGTGAGTCAGGGCTTTAATCCCAGCCTTCAGGAGGCAGAGGCACACAGATCTTTGTGAGTTCGAGGCTAACCTGGTTAACAGAGAGAGTTCCAGGACAGTCAGAGCTACACAGAGAAACCTTGGCTCAAAAAACAACAAAATATCTGAATGGCTGATTCAATGACTGGGCAGATGCACAGATAGACAGATGGACATGTACGATCCACAGACATGTACGATCTTTGCGATGGTGGGGAAGGCTTGGTAGCTAACACAGGCTGGCTCAAGACCTGCTTCTGGGAACCCTTTCTTTCCTTTGTATCCTCAGCTCTGGGTCATGAAGGGTGTGGAGTGGGCCGGGAAGGGAGTGTCAGGCTCAGTGGCTGCTTGCCTTGGATTCTGGCCCAGAGTGTCTGGAGGAAGAAGAGGGTATCTCGGCATCTGAGTCACCTTAGAGAAACCCTAGCCACATACCTGACTTCTGACATCACACAACCAGGGCAACCCTGGTGGCCGAGACAAGGAGACTGAATCATGGACTGAAATCAGTCACCTTCGGCATCCCCACCTGGCCCCTAGTGACCCCCTGAGACACCCCCGAGTCGCTGTCTGCCTGTGTGGCCATCCAAACCACATCAAGGTCACTAAACCCTCTCCAGCCTCACTCAGGGACAGGGTGGCCACTGCCACAGACCACCCACCACAGCATCTGCAGGACAGCAAGAGAAAGTTGAGGGAGAAAAGGCAGAGGGTAGGCCCCAGTCAGGGAGAGGGAAGTGCCTGTGGGAGAAAGGGGAAGCTGTGGCTTGCGGCCAGTAGCCTGGTGACCTCTCGCTGGGATCTGGAATGGGGTCTTAGTGTTTGCGCACAGAATGGCGAAGTTGCAAGCCACCCTCAGAGGACAATGGAGTCACCAGACAATCGGCTCTTACACTTGCACACGCAGCCACAGGCCCACAAAAGCCAGCGTGCGAGCCCTACCCTCCAGCCACCCCAGAGCTACAGCTTGCCACACACACACAACACTCTCCCCACAAGACTCGCTTCCTTTACCCTATTAAGTGACATCCGTAATTCTCATTGTGAAGATTCCAACTCTCGGTATTTTGATGATCTCATTTGATATCAATAACTTACACATTTCCAGTGCCAGGCACTCTTGTAGACTATTTAGCTGTGCTAGGGATTGAACCCAGGGCTTCTTCCATTCTGGGCAAACATCCTGCCACTGACCTTGCTCCCAGACCCACGTGCCCATGGTTTGTCCCCAGACCCCTGTTTTATATGTAATTCTGAGACAACGTCTCACTGTAATGCCCAGAGACCCTTCACCTCACTCTATTACCCAGCCTTGAACTCACTCATCCTTCTGCAGGGATTGTAGGCATGACTAGCTAGACACAGCTAAGTATCTGTTAGAGCGTGTATCTGTACCTTGGGGCAGACATCTGTCCAACTGTATATGTCTATACATTGTTAGGTTTCAAACAAATGGCTGAGGTGCCTATTTAACATATCAAGAGGACCTGGCCCCCAATTTCTCCCTGCAATAACTCAGCTCCTATATGCCCTCCTGGCTGGCATACCCCACCCGCTATCCTGAACTTCTCCAGCCCAGGGGCTGGGCTGTTCATCCCTATGTAATCCAACTATTTTAGCTCTCCCCTCTCTTTCTACCTTAAGGCTGCACCTGGCTCCCATGGCTCCCCTCCCTCTCTCCCCACACGGCTCAGGCTTAAGTCGACTCTCGACTATCCTAGAGGTCCCTGCCTCTGCCTATGCTCTCCCACATATCTATAATAAACTCTCCTCTCCATACCTAGGAACAGTCATGTTCCCTTCCTTTCTCTTTCTTAATTTCCTTTTCTTTTCATTCATACATACGTTTCTTTGGATTCTGTATTCTATTCTCCCTCCTTAAAAATATACACAGCTAGCCAGGCATGGTGATGCACACCTTTAATCCCAGCACTCGAGAGGCAGACACACGTGGATCTCTGTGAGTTCGAGACCAGCCTAGTCTACAGATTGACTTCCAGGCCTGTCTGGCCTATACAGTGAGATCCTCAAAAAGAAAAATGTACACACACTACCCCCTTCAAGTCAGAAGACCCTGAGACACAAGCCCATCCATCGCCGGGCAGCATGGGAAAAGCACCTTGTTACAAATGCCTGGAGTCAGGTCTGACACTCACACACAAGGTCCCTGCCACCAGTTGATCCAGCACCTACATTCGAACGATCAGAGAGGTCCAGATAACTGTGCTGCCCTGTCAGACCTTATGAATGAAGACCTGAATGGAGGCTGATGTCTGTAATTCCAGCACTCGGGACCCACTCAGGACGCAAGGAGGATTGGAGGGACTTAGCTGGAGGCCAGCCTATGCTATAGAGTAAGACTGCTTCAAACAAGAGAAATGAGAACTGAAAAGATTGCTCAGTGGGTAGAGGCGCTTGCCTGCAAGTCTAAGGAACTGAGTTCAATTCCTGACATTTGCATGATGGAAGAAAAGAAACTCCTTCAAGGTCACACACACACACACACACACACTCAAAGAAGTAAAAATACTTTTTAATTTAAAAGAACAGAGAAACTTGAACACATCGTCGGTCTGCCATGTGGCTCTGCACTAATGCCTGCCTTGGATGTATGTAGTCCTGGTTTTGACCCCACCATTATACAGACCAGGTGTGGTGATACAAACCTGTAATTCCAGCACTGGGGGCTGGAGCCAAGACGATGGGAGAAGTTCTAGGTGGCTCATCCTTGGCTAAAAAAACATAGCCTGAGCTACCTGACACTGGTTGCTAGTGTGAGCTATCTGAGACTCTGCCTCACAAATAATTAAGTAAAAATATGGTAGATTCATCACGACACCACCTACAGATTGCCTGTCCTGTGCTGGGACACAGGGCAGCTTCACACTAACCCTGATGGGAACACCTGGGAGACCACATGCTTGTTGCAAGGCGCTGGCTCATCTCAGACCAAAGCGACTTCAGGAGCCAAGTAGACCACAATCCGTGTGCTTCAGACAGTGGGAAGGGCATACAGAAACCTCAGGAACTGAGGCACAGCAGGCAGATGGGAGGCTGGGACAAGGGACCACTGACAGACACCATACATCATACCATCTTGTCCCTCTGAATCTCCATGGGCACCCCCTCTGGGAGGACTCCAGGACTGCAAGCAAAGGTTAACTGAGTCAGCCAATTCAACCCTGGCCTAGGGGGTGGAGGCAGGGGGTCTATCAGCGCGAGGAGACAGGACAAGGACACTCATGTATTGCCATAGGGATGGCTCTCTTGTCAAACCATCAGAACACCCACAAACATCCCGGCTCACAGGGGTCTGCAGGCGTAGGGCTGGGATGTGGCCCGAGACTTGTCCCAACTGAGGAATGTAGTGGCAAAAGTTTGGCCAAGGCAAGACCAGAGGACTCTGTATGCATGAAGGCCAGGGTGATGACATTTCAGGAAAGAAAAGCACAGAATCAAGCATGGTAGGTAGTTGGAAAGTGGAAGCCCGNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNACCACATTTACTAAGCCCCTCCCTGCCAAAGTAAGCAATAAATTATGGCTAAGAGTCTCCCCACTCCTAAGATGGAAAGATGCCAAGCTGCAAAGGAGATCCTGACAACAGACCAGCTACTTGGAAGACTCAGAACCTAGCCAAGCTGCCTGCAAGAGGTTTAGACCAACTAAGACATCTGGAGAGAGCACCCTCCAATCTGTGGAGCAGTCTTCAGCCTCTGCAGGGTCCTCCAGGCTCCCAGCTTTGTAAGCTGTCACTCATGCTGGGGCGCGCTTGGGTGACGCAGCTGTCTTTGAGTGACTTCTCCCGTAAGTCACCCCTCACCCATGCACACTCCTGTAAGTAACTCTAATAGAAAATTCATCGGTTCAGCAAATTGGACTTTCGTCTCTTCTGAGCTGGCTCCCTGTCTAGGGTGAATGGACATGTGTGTGTGGCATCTCCCCTGGAAAAGTTTTCTTTCCCTAGCCTTGGCCTCGGGTCTCCCAGGCTTTTTGCAGTTGCTGGTGGCATCCTTCTTAGTGGGTACTTAAGAATCACGACCCTGGCCAGCGATGCAGCAGCCGTTGGCACAGCGCTCCCCTAGCATGCAGGAGGCCCCTGCATTACATCCCCAGTAATAAACCAGGCCTGGCGACAATATAGACGTGAGAGCAAGATGTTCATTGTCATCCTTGGGTACATAGTAAATTCTAGTCTTTGTTTTAAAAACAAACAAACAAACAAACAAGCAGGACATAAGATCAGATATGCCTGGCATGGTGGAAGGTGCCTTTAACTCCAACACTCAAGAGGTAGAGGTCATCCTGGCCTACAGAATGAATTCCAGGCCAAAGGTGGTACATAATGAGACCCCATCTCAAAAACAGACAGAGAAAGGAGGAGGGCAAAGGGTAGAAAGAGGAGGGGATGTTCACAATAGGGGGAGGGGATGTTCACAATACGTGTATATATATTCTTTCCTTCTGCATGTGGATAGAACCCAGGACTTCACACATGCTAGACATTCATTCCACTTTAAGCTACATTCCCGCCCTCACATCCCCTTTTGTTTAAATCATTAATATTGATATTATTATTATTATTATTATTATTATTATTACTACATATGAGTACTGGTTGTTTTCTGTCTTTCCATGCATGTGGAGATCAGAGAACAATTTTTACGACTCATTTTTCTTCTTCCACCGTGAGTCCCAGGGATCGCACTCAGGTTCTCAGGTATGTGTAGCAAGCTCCTTTACCTGTGAACCATCTTGCTGGGGCTGATACCTGCTGATTGCTAAACACATGCCACCGATTATATTAATGCACTAGTATTTTATTTATTTATTTTTCGAGACAGGGTTTCTCTGTGTAGCCCTGGCTGTCCTGGAACTCACTCTGTAGAACAAGCTCGTTTCGAACTCACAGAGATCTCCCTGCTTCTGCTGGGATTAAAGATCTGTGCTGCTGCCGCAGCTGCCACCACCACCAGACACCACCAATTATTATTGTTCAATTATTATTGTATACACACTTTCTTTTCTGTCTCCTGAGCTAAGTGGGAAGGAGAGGCTTCCAACACCATCAAGCCTGAAGAACTCACCGGGTGTGGGTTCCTACCTGCTCCAATTCTGCAGGTCCCCCAGATTCAGGGACCCGGAAAAGCCACCTATCCTTTGCTTAGCTATGAGTACTGAAGTTTTAGATCAGCCAGGGAGCACATTTTCCAAGCTCACCGAGTCACACAGAATCCGTGACAAAGCTACTGGGGAGGGGACTGCATCCTTACCCATCCCTACACCTGGGGATATCACAGACTCTCCAATTCCCCCTGAGCCTCAGTTTCCCCACCTACACTGATTATACCCCTCTCGCCAGAATCTGCACTGGGGACCTTCCTCTTTTTCACCACCAGGGGCGCTCCACCGCTTTGGGGAGGGTGGGGTCCCACGGGTATAAGCAGACCTCCCATCTGGAGTTCCACCTTCTCCAACCCGGGTCAGCAGGGGCCTTCTGAGGGAGTTTAGGCGCCTGTCAATCTCAGCCTCCGGGACAGCGTGGAACTGCGCAGGCGCGGGCGGGTTCCGCACAGCGCAACAGCGGGCGCGCGCGGGAGCGAGGGATTCCCTCTGACGTAATTGCTAGGATACCAAACAAACACTGGGCCGCGCTGGCCGAGCTCCTTATATGGCTAATTGCGTCACAGGAACTCCGGGGAGGGCGGGGCGGGATCCCCTCCCGCGAAGCCCCTCAGAACGCAGCCTTGGGGACCCCCCAGACCCCCAGGGTCACACTATCGCCAGGTGGCAGGTGCACGAGGCCCTCGAGGGCGCCACAAGGAGCTCAGTCGGCGGGAAGGGAGAGTTTGCGAGGTTTGTGCATGGAGTTGCGGGTGACGCAAGCGCGGGGGGCGGGTCCCGGAGGCATAAATTCAGCCCGGCAGCTCCCGGTTTCATTCATAAGACTGGAGCGGCTACGCCGGGGACACCCCCACCCGGGGCTTGCTGGACTTGACTACTGGTCACTCTTTCTTTTTCTTCTTCTTGGAGGCCGTGAAAAATTTATATATATATATTTATATATATTTTTAAACTGGAGAGAAAGTTTTGTGGGTTTCCTTTTTGCAAGACTCTTTCTACATCGTTCTTCCGATTCGTCCCCACGATACACTTTCTTTCTGTGGGCTTCTGGATCGCGCCCCTCTGCTCTCCCTCATTTCTTGGGACGCTTCGACAGGATTCCAACTCCATCTGAAGCGCACGCTGCACCGCGGCACTGCCCGGCGGGTTTCTCCGCGGGGAGCGATCCCCGCGTCGCCCCCCGTGAAACCGACAGACCCTGGACTTTCAGGAGGTACAGCGCCGCTCTGAAGGGGATCTGGGATCTTGCAGAGGGAACTTGCATCGAAACTTCCGCAGTTCTCCGAACCGGAGACTAAGCTTCCCCGAGCAGCGCACTTTGGAGACGTGTCCGGTCTACTCCGGACTCGCATCTCATTCCACTCGGCCATAGCCTTGGCTTCCCGGCGACCTCAGCCTGGTCACAGGGGCCCCCCTGTGCCCAGGGAAATGTTTCAAGCTTTTCCCGCAGACTACGACTCCGGCTCCCGGTGTAGCTCATCACCCTCCGCCGAGTCTCAGTACCTGTCTTCGGTGGACTCCTTCGGCAGTCCACCCACCGCCGCCCCCTCCCAGGTAAGTTCTAGATCGTAAAGATTCTACTTTAGTGGTTGGGGCGGGGTGTTTCTTTCAGGCTAAAGTGTAGATTGAGCATCCTCTCAAATAGAGACGCGCCAAAACCCAGGATCTGGGATTGCAATAGTTCGGTTTGCACTTTGGTTTTTTGTTGTTTGCAAACTGCAAAGAATGGAGTGATGTTTGCAAAAGGTTATTTGCGCGGAGCGCGGGAAAGGAATGCAGCTGGGCAAACGTTGGCGATGCCCGGTGCAAAGTATATACCCGGTGGTTAGCAGAAGCTGAGAACTTTTAGCCGAAAGCCGGCTCCCTAAGCCGAAGCTAGGCAAGTAGGGGAAGAAAAAGAAACAAAAAATTCCAGAGAAGCTTCCAGGAGCCTCCTCCTCTTCCCTCTTCCTTCAAAACGCGGACTGCAAGTCCGCAGTCACCCTCCACCCAGCAAGAGTTAGGGCCTCGAACCCCGGTCACCCTGCCTCCGCCTCCTGCGCGGAGACCTAACGGGGGACCCGTGCGTAAAGGCTGACGCGCTGGAATCCTCCGTCTGACGCGGGGCACGCACAGCGCCCAGCGCCCCCTCCGCCCGCCCCGCCCCTGACGTCCCGGGCACGTTCTATTTTGGAACGCCGAGGCCACGTTGCTAAGGGAGGGGGCAGCGTGGCTTTGTGATTGGCTGTCGCGGCGCGAGCTTTAGCCAATCAGCGTTCCCTTCCTATTTGTACAGCGTAGCTCCCTTCCTTGCTTTTTGTGGTTCTTCCCGTGCTGGGGGTCTCCAAGAGGGACAGCTAGGCGATTCTTGTCGCGATCGGGGGACTCGTTGTCACCCCATGGGTCTGCGACGACCTTGTGTGGACCTGGTCCTGTTGTCATAAGCTAGAGGCTTTTGGCTGAGTGTTAGCGCCTCTAAGGGGGAACTGAAGGCCTCATCCCTTCTCCAGGCACACATATACGTGCTCCCTGACCTCTAGACACTCAGTCCTTCCCAGGTGTTCAAACACTAGATGAGCTAGCCTACGGAGAGGCAGCCAGGTGGTCTCTAAAAGGTCCGCCTTCCCTTACTTCCCAGGGCTCTGATTGGCCAGGGATTCACCCCTTCCCTCGCCACGCCCCCTAGACTAGTTAAGCCTCTAGGATTCCACTTGCGGGAAGGGGGGGGGGCGCGTGATGGACGCTTCTTGGGTTCGGCGACCCAGATCCTATGTCACCCCATCCCCTGCAAGACAGTCTGAGAGATTCTCGCTGTCACTTTTCTCTGCCTATCAGTTCACTGAAACCTGTCACTCTCACTCGGGAAGAGACAGACACTCGGAAGGGATGCTCTCAACTCTTAGGCCGGTCCCCCAACACCGTTGGAACTGGGATCTCCGCCCCTGCGGGAGCCCTCATGCAGTGGGGGGTGTGTTTGTGTCTCAGTGGAGGAGAGGAAGGCTTGGGCTAAGGCCTCTCCCTCTCCCTACCTACTGTGGTGGGGGTGGGGTGTTTTGGCTGTATGTGTGTGTGANNNNNNNNNNNNNNNNNNNNCTGACTTGAAGGGGGTAGTGTGTGTACATTTTTCTTTTTGAGACAGGATCTCACTGTATAGGCCAGACAGGCCTGGAACTCAATCTGTAGACTAGGCTGGTCTCGAACTCACAGAGATCCACCTGTGTCTGTGGCTCCAGTCCCGGGATTAAAGGTTTGCATCACCAGGTTCTGTCCAGCCTCCGTCTCCCACCCACCCCCCCACACCTAAGAGTCACCAACCCGGGGTGTGATTCACCACCCGCTGGAACCGTGCAACCTTTCCCCGAGGAAGAAGGAGGAGGTAGAAGGCAGTTGAACAGAATCTCTCATTAACCACTGCGTCACGGTGTAGTGGAAGGGTGGGTGTTGTGGCTTTTTGCCTGTGACACACACATCCACACCCGCTCACCCTGTGCTCACTCACAGGGGTCGGTGTGTGTTATGTGTGTTGGGCGTGTGTGTGTCCGTGGCTTTGTTTGTGTGTCTACGCCTGTGTGTGTATGTCTCACCCCGTACGAGTGCGCCGGTCTCGGGGAAATGCCCGGCTCCTTCGTGCCAACGGTCACCGCAATCACAACCAGCCACGATCTTCAGTGGCTCGTGCAACCCACCCTCATCTCTTCCATGGCCCAGTCCCAGGCGCAGCCACTGGCCTCCCAGCCTCCACCTGTTGACCCTTATGACATGCCAGGAACCAGCTACTCAACCCCAGGCCTGAGTGCCTACAGCACTGGCGGGGCAAGCGGAAGTGGTGGGCCTTCAACCAGCACAACCACCAGTGGACCTGTGTCTGCCCGTCCAGCCAGAGCCACGCCTAGAAGACCCCGAGAAGAGACAGTAAGTATGAGGCCTCAGGAGTTGGGATGGAGGAGCCTAGCTAGGCATGTGGGCTCAGTTTGTACAGTGCTTGCTGCCATGCATGAAGATCCCTAGCACAGCATAAGCCAGGAGTGGTTATGCACACCTGTAACCCCAGCTCTCAGAACGTGGAGGCAGGAGGAGGAGGAGTTCGAGGCCAGCCTGTGCTACTTATGCAGTCCAGCCTGCACTGCAAGACATCATTATTTTCAAAAGTTGGCCTTGGGGGGAGGTGGGTGAGGGAAGTAAGAGAAAGTGACAGTAATTTTATCACTTAATAGTTGGAGGTTCCTCTGAGGCCTCAAGTCTGAAGGAACTTTACCATTCTGGCCAGTGAGGAGTAGGGGTTATTATTTGGGGTTCAGGAGGAAGGAGTTTTCTTAGGGCTGATAGAGGTACCCCCAGATCTCATGGTCCTTATCTCTGACTCAGCTTACCCCAGAAGAAGAAGAAAAGCGAAGGGTTCGCAGAGAGCGGAACAAGCTGGCTGCAGCTAAGTGCAGGAACCGTCGGAGGGAGCTGACAGATCGACTTCAGGCGGTAAGGAGGAGTCTGGGGGTGTCTTGAGGCCGTGCTGGGAGCACTCTGCCTTGTTCTTCCCCCGTTTCTCACTGTGCCTGTGTCCTAAACGAGGAAACCCCCTCTTAGGGAACAGGGGTCAGTATAGGCTGATGGAGTGGCTCCATATGCATGCTCAGACCCATGCCCACTTACTTTCGACTGTTCCCCACTTTCCCTGAATATGTCCCCACATGTCACCCTCCTGGCTTTCTCTCAGCCTAAGGAGACAAGCTGGAGGAGGTAATTCTCTCACCTTCTTTCCTTCACTAAATAATAATCCATTTTGCCTTCCTGCCTCCATTTTTTTTTCCTGAGCTGGGGATCTACCTGTGTAGTTCAGCCCTCCTCCCCCAACTTGATAGCCTCAAGTTTCACCCCTTGGCTGAGATGCCATCATCCTGACTGGCTCTGGCTGGAAACTATTTTGTGCTAAGTCAATTCCTTACCTGCTACTCCAGCTATCTACAGTTCTGCCGAACTTGAGCTCGTGGCGCCCACCAAGCCCACTTCTTTCTCTCTTCTACCTCAGTGCAACCCCCACACACACACACACACCTCATGCCTGCCCCTTGAAACCAGGGTGTGTCTCTGATTTCCCGTCGGGAGGCTGAAGGAGATGGGTAACAGAACCTCATTAAAAACAACACATAAGCATTACCTACTGACTCAACAAACTGTAGTGTTTTTCTTTTTTCCTCTCAAAAAATTATTTCGTTTGTTTATTTATTATTTGCTTATGTTTGAGTGAGTCCTGGTGCACCACAGCACACATACGACCTCAGAGGGAAATTTTCATAGTTTGTTCTCTCCTTCCGTGTTGTGGGTGCTTGCTGGCAATCTCCTTCACTCAGTGAGCTACAATGCCCCCTTCTGCCCTTTAAGGCAGAGTACTCCTTAGTACAGGGGGACCCTTTCCTCCGCCTCTCAAAGTTGAGATTACAAATGTTCACCATCACACCAGGCTTGGAGTTCTTGCCTATCAGTGACGTCCACTCCTGCCTAGCTTCTTCCCAACCATCTCTTAGTCTGATGGGGAAACCGAGGCACGAGTAGCATGGTCTACCAGGATTTCCTCTTAGGGGACGCTCCCCTCACTTGGGAGGGAGCTGTCCAGCCCCCTGGATCAGCAGCAAGAATGTATGAGTGTGGGGTTGGGCCCGTGAAGCTACTCTGTGTGGTCCCTGACCAGCAATTCTCCTTTCTCTGTCTCCTATGACCTGGCCCTGCTGGGATCCATTAGGAAACTGATCAGCTTGAAGAGGAAAAGGCAGAGCTGGAGTCGGAGATCGCCGAGCTGCAAAAAGAGAAGGAACGCCTGGAGTTTGTCCTGGTGGCCCACAAACCGGGCTGCAAGATCCCCTACGAAGAGGGCCCGGCGCCAGGCCCGCTGGCCGAGGTCAGAGATTTGCCAGGGTCAACATCCGCTAAGGAAGACGGCTTCGGCTGGCTCCTCCCGCCCCCTCCACCACCGCCCCTGCCCTTCCAGAGCAGCCGAGACGCACCCCCCAACCTGACGGCTTCTCTCTTTACACACAGTGAAGTTCAAGTCCTCCCCGACCCCTTCCCCGTTGTTACCCCTTCGTACACTTCCTCGTTTGTCCTCACCTGCCCGGAGGTCTCCCCGTTCGCCGGCGCCCAACGCACCAGCGGCAGCGAGCAGCCGTCCCACCCGCTGAACTCGCCCTCCCTTCTTGCTCTGTAAACTCTTTAGACAAACAAAACAAACAAACCCGCAAGGAACAAGGAGGAGGAAGATGAGGAGGAGAGGGGAGGAACCAGTCCGGGGGTGTGTGTGTGGACCCTTTGACTCTTCTGTCTGACCACCTGCCGCCTCTCCCATCGGACATGACGGAACGACCTCCTTTGTGTTTTGTGCTCTGTCTCTGGTTTTCTGTGCCCCGGCGAGACCGGAGAGCTGGTGACTTTCGGCACAGGGGGTGGGGCGGCCATGGACACCCCTCCTCCATATCTTTGTCCTGTTACTTCAACCCAACTTCTCGGGATACATGGCTGCCTCCGTGGGTAGGGTGGGGTGCAACGCCCACCTTTGGCGTCTTGCGTGAGCCTGGAGGGGAAAGCGTGCTGAGTGTGGGGTGCAGCGTGGGTTGACCTCGAGCTGCCATCCACCTCCAGAGAGACCCAACGAGGAAATGACAGCACCCTCCTCTCCTTCTTTTCCCCCACCCACCCATCCACCCTCAACCGTCCAGGGTCACCAACATAGCTCTCTTTTCCTCCCTCGCGCCTTAGCTGATTAACTTAACATTTCCAAGAGGTTACAACCTCCTCCGGGACGAATTGAGCCCCCGACTGAGGGAAGTCGATGCCCCCTTTGGGAGTCTGCTAACCCCACTTCCCGCTGATTCCAAAATGTGAACCCCTATCTGATTCCTCAGTCTTGCCCTCCTGGGAAAACTGGCTCAGGTTGCATTTTTTTCCTCATCTGCTACAGAGCCCCCTCCCAACTCAGGCCCGCTCCCACCCCTCTGCAGTATTATCCTACCTCCCTCTCACCCTCACCCCCACCCCAGGCGCCCTTGGCCGTCCTCGTTGGGCCTTACTGGTTTTGCCCAGCAGGGGGCGCTGCGACGCCCATCTTGCTGGAGCGCTTTATACTCTCAATGAGTGGTCGGATTGCTGGGTGCGCCGGATGGCATTCACCCCCAGCCCTCCAAAACTTTCCCTGGGCCTCCCCTTCTTCCACTTCCTTCCTCCCTCCCCTTCACAGGGAGTTAGACTCGAAAGGATGACCACGACGCATCCCGGTGGCCTTCTTCCTCAGGCCCCAGACTTTTTCTCTTTAAGTCCTTCGCCTTCCCCACCCTAGGACGCCAACTTCTCCCCACCCTGGGAGCCCCGCATCCTCTCACAGAGGTCCAGGCAATTTTCAGAGAAGTTTTCAGGGCTCAGGCTTTGGCTCCCCTATCCTCGATATTTGAATCCCCAAATATTTTTGGACTAGCATACTTAAGAGGGGGCTCACTTCCCACTATCCCACTCCATCCAATTCCTTCAGTCCCAAAGACGAGTTCTGTCCCTTCCCTCCAGCTTTCACCTCGTGAGAATCCCACGAGTCACATTTCTATTTTTTAATATTGGGGAGATGGGCCCTACCGCCCGTCCCCCGTGCTGCATGGAACATTCCATACCCTGTCCTGGGCCCTAGGTTCCAAACCTAATCCCAAACCCCACCCCCAGCTATTTATCCCTTTCCTGGTTCCCAAAAAGCACTTATATCTATTATGTATAAATAAATATATTATATATGAGTGTGCGTGTGTGTGCGTGTGCGTGCGTGCGTGCGTGCGAGCTTCCTTGTTTTCAAGTGTGCTGTGGAGTTCAAAATCGCTTCTGGGGATTTGAGTCACACTTTCTGGCTGTCCCTTTTTGTCACTTTTTTGTTGTTGTCTCGGCTCCTCTGGCTGTTGCAGACAGTCCCGCCCTCTCCCTTTATCCTTTCTCAAGTCTGTCTCGCTCAGACCACTTCCAACATGTCTCCACTCTCAATGACTCTGATCTCCGGTCTGTCTGTTAATTCTGGATTTGTCCGCGACATGCAATTTTACTTCTGTAAGTAAGTGTGACTGGGTGGTAGATTTTTTACAATCTATATCGTTGAGAATTCTGGGTGGAAATGTCTGATCAGGAGAAGGGCCTGCCACTGCCGACCACAATTCATTGACTCCATAGCCCTCACCCAGGCTGTATTTGTCATTTTTTTCATTTTGTTTTTTTGTATTTTGCACCTGACCCCGGGGGTGCTGCGGCAGTCTAGCACTGGGCAGCTCCCCTCCCCCCCTTGGTTCTGCACTGTCGCCAATAAAAAGCTTTTAAAAAACTGTATTCTTCAGGTCAAAGTGTCTGTTTTCCCTGCACATCTACTACATCGCTTCCTTTCAGAAAAACGGAGTTTGGATTGCTAGGGAGGTCTTGCTCGCACTTAGTGGGACGCCTAATGAATCAGAACCTACAACGGGACTAAAAGGAAGTGGAGACTTGCTAGGTTTTCCCATGTTCCCAGGCTGGGCCACCTACTTGAAAAAATAAGGGGCGGAAAAGTGTAAGGTACAAATTTGGTGAAGGGTCTGGAAGACTTCATGATCGGAAAAGAATTTATTCACCTTGGGTGTGCAATGACTTCAGCAACAGCTAAGGGCAAGGTGTAAAAGCTGGGCACACTTGTAAATCCTAGCATTTGAGAGGTGGAGGCAAGCGGATCACTGGTGGACTTCAGTCTCATGTGGATCGTAGATACCAAGCGCAAAGATCTGCTATGGGGACAGGGCTTGGTACACCAGGGGAGCCAGAAGTTCGTGGTGAGGGTAGTGGAGCCCAGCTCGAGACTCAGAGTTAGCCTCAGGGAGATTCTACAGGCAATGATGCAGAGTTCAGACGCTCCTTTGAAAGCACTAGAGAGCCGCAGCAGGTTTTGAGCAGAGAAGGTTAGCGTTAGGTGGTCTCTTCTAGCCCATCCCAGGCTGAGGAGGACGCTGAGGGTTTCAAGAAGGATCGAGAATGGAAAGCAGAGGAGAAAAAGGATCCAAGAGGCATGGAGGAGGCAGAACACATTTCTCTTCTTTAATAGCAAGCCTGGAAAGGATAACTTGCTGCAGGAGGAGATGCTCACCAGTCGGGTGGTCTAGGGGGTTCTTGGAAAAGAGAACGCATTTGCTCAAGCCTCGGTTCCCCCATTCTCGCTCTTCTGTCAGCTTGTCTTCCATTAAGTGTGTGTCTCAAGGCCACCCTGCTCAGGACTCCTTGTGAGACGACCTTCTATGCTCGAGTTCATTAAAAACACAATTGCCTGGTGCCCTGCTCTCTCCACTGGCTCAGTTACCTCAAAAGACCAGGGCTAAAGGTGTGATCACAACTCTATCCCCATTACTGCTCCAACGCAGAGACAGGACTGAGCCGGAGTGAACAAATGAACAAAAATGACTAATAATGCATGCGTGATTAAATACATAAAAGAGCAGATGACTGGATGAGCAAATCGTTTAAGGAGAGACAGCAAGATCCTAGAATTTTGGAGACTAATTTAAATCCATCTTTGAGATGTATTTGGTCGGAAATTCCTGGGAGGAAAAAAAGTGTAAGTATGAAGAGAGAATAAATGAGAATAGGGGTGGCTTCAGAGAGGTTAACTGCGCGCTGGTCGCTTTTGTACAAGAATGTGAATTGCAGGGAGCAAAATGGGATAGATACTCCCGCCCCAAAGCTGGAATTGAACCACTCTGTCGCTAAACAGCTACAGGTTTGAAGCCTGCACCCCAGACCACTGAGGATCATCCGGGCGAAAGGAGCTATTTTCGGTTAGTTATATAAACCCCAGATACTACTACTTTTTTCACTTATGGTCATTATTTCTGGTATACAGTAGATAATTAATTTCAATGCTTTCGAACATTTTTTTTCACTTTTTCTTGTGAACATGTGTTTCCTCAGTAAAGTGTTCCGTGAATGACTCTACTAACTAAAAAGTAAGTAGCTTCATTTGCATAGCGCCTTGCATTCTGGGAAGCAGCGCCTAAAGTGCCTGTCTCCCTAACTAAAAGCAGAATTTTTTGCAAAGTGAAAAGTCAGTTTTATTTTTGTTTGTTTGTTTGTTTGTTTGTTTTTAATGGAAAAACTTCTCACCCGCCCCATTCGTAGCAGAATTCGAGATTTTCTGCAAGCGAGACCGTAGGGTCTGACGGCACGCGCCCGCAGAGCCACACCTGCCGTTGCTTTATAGAACTGCAAGTATGTAGGGAATCTACTCACTCCCTAAGGTGATGGAGTTGACAACCAACTCCCCTTGCGTTTAGACGCTAAAAACCATCCCTTTTTATATCTATGTGATTAGCCCAGGGAAACTAAGGCTCAGACATGGATAATACCACAGCCGAGTTCCTGTAGCCCAACTCCCTAGGGGAAATGAAACCTACAGTTGTGGTTTTAATATGCTTGGCCCAGGGGCAGTGGCCCTATTGGCAGGAGTGGCCTTATTAGAGGAGGTGTACCTTGTTAGAGGAAGTGTGTCACTTGGAGGCGAGGTTTTGAGGTACGTATGCTCAAGTCTGGCCAGTGTGATCCTGGCTGTCTGCAGAACGCCGTCTCCTGGCTGCCTTCGGATCAAGGTGTAGAACTCTCAGCTCCTTCTCCAGCACCATGTCTGCCTGCTTAATGCTTTGCTTCTTTCCATGACGATAATGAACTGTGCCTCTGAAACTGTAAGTCAACCCCAATTACACAATTACATGTTTTCTTTTATAAGAGTTGCATATATATATATATATGTCACACTCTTTAGCTCTGGCTGGCCTGAAATTCACTATGTAGCCCAGGATTGCCTGAACTTTGAAGCAATCTTCCTGCCTCAGCCTCCCAATGGTATTACAGGCATGAGTCACAACAAGCCATTTAAATCTTATGATGACTTATAAGAAGACAGAAAATCAGAGTTCCTTTACCTAGTTCACAGATCCCTACAATCTAACCTCGTTCGCTCCATAAACAGCCCTACCCCACCCTCCTGGAACTGCTTTGAGGAATGCTCCAGCCTCTCACAGGCACACTCCTCCTTGGTTAATCTCTTCAGCCTGGTTGCCTTCCCTCCCCATGTCCATGTGGCCCAAAGCCTCTCATCCTGTTCTCAAATACCACTAGCTAGTAAGGCCTCCCCGACCTGACCCCGGTTTAAATATTAGAAAAGGGTCACTTTCTCCCCTGCCACAGACAACCAAACCACCATATGCTTGTCACTTACTACCTGACTATGAAGGTGAATAGATGTCTTCACAACCTTTCTCTGAGCCTCAGTTTCCCCACCTCCATAATGCATCTGAGACACAGAATTCCCTAGAGCTGTGGTTCTCCTCATTCCTAGTGCTGGGACCCTTTAATACATTTCCTCATGTTGTGGTGACTCCACCACCACCATAAAATTATTTTCATTGATACTTCATAACTGTAATTTTTTCTATTGTTATGAATAGTAATGTAAGCATTTGTGTTTCCCAGTGATCTTAGATGACCCTGTGGAAGAGTCATTCCACCCCCAAAGGGGTCCCCACCACAAGTTAAGAATTCCTGCCATAGAGCAATCACAAGGAACCAATGAATTACACTTTGGGTCGACTTTTGGGCTGGCCTCTGGGAGGCGNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNCTTGGATTACAAACATGTGCCACCAAGTCTGGCTGCCCATTATGCATTTCTGTGGCAGGCGTTGATGGCTATTAAACCCAAGCCTTGTATATACTAGGCAACTACCCATCCACTGAACTACAGCCCTAGCATGGACCTCACAGGGCAATGGCCTGACATCTGGGAAACACTATCACAGAGTATAATAATAAAACCGTAGCATCCTTTTCACATTGAGCATTTCTGCTGGGTCACACTTCCAAAACCTTCTTATTGTTATCATGAGTATGTGTGCATACATGTCGAGGTGAGAGGATGACGTCATAGAGACAGCTCTGTCTCCCATTCTTTATTGCCAATATTATTTTATGTTTTGTCTGCGTGTATGTTTGTATACCAAAGTCCATGCAGTGCCTGTAGAGACCAAAAGGGGGCATCCCTGAGACTGGAGTTAGAAGTGGCTGTGAACCACTCACTCTGTGGGTGCTGGGAATCAAACCCCGGTTCTCTGGCAGAGCAACTGGTGCTCTTAACCACCGAATCAACTTCTCCAGCCCTGCATTGCTTTAATCTTTTGGTCGATTCCCCCAATCCAACTCATACCGCCAAGTCTGAGTAGCAAGTGCCTTTATCTGGGAGACTCACTGATCTTATTTTTTTTTCCTTTCTTTTTCTTTCTTTTTTTCTTTTTTTTTTTGAGTCAGGTATGATTATTTAGATGGCCTCGAACTCACAGAGATCCACCTCCCTCTGTTATGCCAGGCTTTTAAAAAACAACATTTATTTTTGAATGCATATATAGGGCTGTGCAAACACAGCCTGAAGGAGTCGTTTCTGATTGCTCACAACGTGGTTCCAGGGATGGAACGCGGGTGACCAGCTTGAAGGTAGGTGCTTTCACCAGCCCCAAGAATTTATTTTTTAACTTTATTTTTTTAATTAAATCATTAAATGACACATGTTCATTGTGGGTAGTGCAGGTATGCCATCGAGCACATGTAGAGGTGACATTACTGCAGGCGGTCTCTCTACCATGGGGATTCAACTCAGACCACTGCTTCCTTTACCAGATCATCATTCTTGCATCCCCCAATCATTTCTTTTTGTTGATGGTTTTGTTTGTTTGTTTTAGTTTTGGGGGGTTTTTAAAGTTTTTTTCGAGACAGNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNATTAAAGGCGTGTACTACCACTGCCTGGGCATAACCGGCCTTTCTGCCTTATTTGTTTCGAAACGGAGTCTCATGTAGCCTGAGGTGGCCTCAAACATGCAATGTAGCTGCAGCTGGGATTACATATCTTCACCACCACAACCTGTTTTATGCACTGCTAAGAGATTAAACCTGGGCCTTCGTGCTAGGTAAGGACTCTATTAACAGAGCTACAACCTCTGCCTGGTTTTTAGTTTTTCAGACAGGGCTTTGCGACATAGCCCTAACTGGCCTTGAACATGCAATGATCCTCCTGCCTCGGCCTCCTGGGTCCTCAGATTGTTGATCCTACACCCACATATCTCAGACCTGAGGGTTGGCAGCTTGGGCCATGCTCTGATTTGGGAGTGACATATTAACAGTAGTTTAATACGAATTTGAATCCACCTTACTTTTTTGGTGGCACTGACATTGAACTCATGGCCTTCCACAGGCTTTTACGTGAGAAATGTTTTACCTCCCTTCCTTGAGCCATGAGCGAGCCCCTCACTGGTGGAGTCTATGCAGCTGGTCTGAAACTCATACCATCTTCCTGCCCCACTCTCCGAGTGCTGAGTGTCTACAGAGCTCCTGACTCTGCCTGGGACGTCATGTCTGTGGGACCTTGCCTATAGAAGGGAGGCAGTCACACCACCCATTTTTGGCTTCCATGTCGGCAATGGACACCTTGCCATACTCACCTGATGTTGTCTGTACAGAAGGGGGACGGTAAACAAAGCAACCACTCCTACAGATGCAGAGAGAGAGATGGGGGATGGGGGGTGTCAGGTTCTCCTGGCAAAGGGTCAGCTCCGTTGAGCGCTTTTCCACTCCCGACCAAATTCCCAAAATAACGACTCTGAGACTCAATATTTCATGAACAAATGCTTGGGCTAGCTTGCGCTTGTTCCCTGACAAGCCCCTATCTCATTTAACCCGTTTATTCTATTCTATGAATGCCACATGCCTGGTTACCTCGTCTCAGTTTCATGAGACCCTCTCATCAGCACTAGGGCAAACCCTGATTCTATTACTCTCTTCCTGCAGGAGCTCGGGCCCCCTATTTCCTCCCTAAGCTAATAGCCCAACAGCTTTTCATTGACAGGTGATGCTTCCACACAGTGCACACGAAGATTCTCTTTACCCTCCATGTGNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNATTTTTGTAGAGAGGGCTGAGGTCAAGTTTAAGATTAGGAAAGAGAATCAAGAATTATCAAGGATAAAGGGAGAGGTCAGGATTTACAGGGGAGCAGGGTTCATGGTCAGAATGAAAATGGATCAGAGAGGCCAATGCGTGAGCTGAGGTCAAGGGTCACAATGGACGGTCCGTCGGCGGGGGCTGGGCAGGGCCAAGCATTCTCACTGGAAACGGTTGGTGCCGTCGCCCCGGTGCACGCCCTGCAGCACTTTGCGGTAAACCCTGAGAGAGATGGTGGCGCAGAGACCCAACAGGGCCAGGTGCGCAGCCACGGACACGATGCTAAAGTGCAGGAGGCAGAGGAGAGAGGCCATGAGGCCCGTGAAGACCGCTCCCGACGTCCTGGTGTCCTTCCAGTACAACAGGTCTGCCACTGTGGAAAAGAAGACAATGTTGGGACCCGACCTGACCAAGCTCACTCCCTTTCTGTTTGTTTTTTAGAGATAAGGTCTCACTATGAAGCTAAGGCTGACTTCAAACTATCAAACCCTCGCTGCTCTTGAACTCCTGATTATTCTAATTCATCCTTTCTTTTTCTTAGACTGAGTTAAGTTTGACCGGCTTCAAACTCAAGACAAATACTCCTGCCTCTACCCTTTAGTGCTTCAAGGAGGTGCTAAGCATCAAATTTAGGGCTTCATGCATGCTAGGTAAAACCCAACTGAGCTACTTCCCTGAC MOUSE SEQUENCE - mRNA (SEQ ID NO: 8)ATAAATTCTTATTTTGACACTCACCAAAATAGTCACCTGGAAAACCCGCTTTTTGTGACAAAGTACAGAAGGCTTGGTCACATTTAAATCACTGAGAACTAGAGAGAAATACTATCGCAAACTGTAATAGACATTACATCCATAAAAGTTTCCCCAGTCCTTATTGTAATATTGCACAGTGCAATTGCTACATGGCAAACTAGTGTAGCATAGAAGTCAAAGCAAAAACAAACCAAAGAAAGGAGCCACAAGAGTAAAACTGTTCAACAGTTAATAGTTCAAACTAAGCCATTGAATCTATCATTGGGATCGTTAAAATGAATCTTCCTACACCTTGCAGTCTATGATTTAACTTTTACAGAACACAAGCCAAGTTTAAAATCAGCAGTAGAGATATTAAAATGAAAAGGTTTGCTAATAGAGTAACATTAAATACCCTGAAGGAAAAAAAACCTAAATATCAAAATAACTGATTAAAATTCACTTGCAAATTAGCACACGAATATGCAACTTGGAAATCATGCAGTGTTTTATTTAAGAAAACATAAAACAAAACTATTAAAATAGTTTTAGAGGGGGTAAAATCCAGGTCCTCTGCCAGGATGCTAAAATTAGACTTCAGGGGAATTTTGAAGTCTTCAATTTTGAAACCTATTAAAAAGCCCATGATTACAGTTAATTAAGAGCAGTGCACGCAACAGTGACACGCCTTTAGAGAGCATTACTGTGTATGAACATGTTGGCTGCTACCAGCCACAGTCAATTTAACAAGGCTGCTCAGTCATGAACTTAATACAGAGAGAGCACGCCTACCCACCAAGCACAGCTTGCTGGGCCACTTTCCTCCCTCTCGTGACACAATCAATCCGTCTACTTGGTGTATCTGAAGCGCACCCTCCACCGCCGCACTGCCCCGCGGGTTTCTCGGCGCCCAGCGATCCCCCCGTCGCCCCCCGTGAAACCGACAGACCCTGGACTTTCAGGAGGTACAGCGGCGGTCTGAAGGGGATCTGGGATCTTGCAGAGGGAACTTGCATCGAAACTTGGGCAGTTCTCCGAACCGGAGACTAACCTTCCCCCACCAGCGCACTTTGGAGACCTGTCCGGTCTACTCCGGACTCGCATCTCATTCCACTCGGCCATAGCCTTGGCTTCCCGGCGACCTCAGCCTGGTCACAGGGCCCCCCCTGTGCCCAGCGAAATGTTTCAAGCTTTTCCCGGACACTACCACTCCGGCTCCCGGTGTAGCTCATCACCCTCCGCCGAGTCTCAGTACCTCTCTTCGGTGGACTCCTTCGGCAGTCCACCCACCGCCGCCGCCTCCCAGGAGTGCGCCGGTCTCGCCCAAATGCCCGGCTCCTTCGTGCCAACGGTCACCGCAATCACAACCAGCCAGGATCTTCAGTGGCTCGTGCAACCCACCCTCATCTCTTCCATGGCCCAGTCCCAGGCGCAGCCACTGCCCTCCCACCCTCCAGCTGTTGACCCTTATGACATGCCAGGAACCACCTACTCAACCCCAGGCCTGAGTGCCTACAGCACTGGCGGGGCAAGCGGAAGTGGTGGGCCTTCAACCAGCACAACCACCAGTGGACCTGTGTCTGCCCGTCCAGCCAGAGCCAGGCCTAGAAGACCCCGAGAAGAGACACTTACCCCAGAAGAAGAAGAAAAGCGAAGGGTTCGCAGAGAGCGGAACAAGCTGGCTGCAGCTAAGTCCAGGAACCGTCGGAGGGAGCTGACAGATCGACTTCAGGCGGAAACTGATCAGCTTGAAGAGGAAAAGGCAGAGCTGGAGTCGGAGATCGCCGAGCTGCAAAAAGAGAAGGAACGCCTGGAGTTTGTCCTGGTGGCCCACAAACCGGGCTGCAAGATCCCCTACGAAGAGGGGCCGGGGCCAGGCCCGCTGGCCGAGGTGAGAGATTTGCCAGGGTCAACATCCGCTAAGGAAGACGGCTTCGGCTCGCTGCTGCCGCCCCCTCCACCACCCCCCCTGCCCTTCCAGAGCAGCCGAGACGCACCCCCCAACCTCACGGCTTCTCTCTTTACACACAGTGAAGTTCAAGTCCTCGCCGACCCCTTCCCCGTTGTTAGCCCTTCGTACACTTCCTCGTTTGTCCTCACCTGCCCGGACCTCTCCGCGTTCGCCGGCGCCCAACGCACCAGCGGCACCGAGCAGCCGTCCGACCCGCTGAACTCGCCCTCCCTTCTTGCTCTGTAAACTCTTTAGACAAACAAAACAAACAAACCCGCAAGGAACAAGGAGGAGGAAGATGAGGAGGAGAGGGGAGGAAGCAGTCCGGGGGTGTGTGTGTGGACCCTTTGACTCTTCTGTCTGACCACCTGCCGCCTCTGCCATCGGACATGACCGAAGGACCTCCTTTGTGTTTTGTGCTCCGTCTCTGGTTTTCTGTGCCCCGGCGAGACCGGAGAGCTGGTGACTTTGGGGACACGGGGTGGGGCGGGGATGGACACCCCTCCTGCATATCTTTGTCCTGTTACTTCAACCCAACTTCTGGGGATAGATGGCTCGCTGGGTGGGTAGGGTGGGGTGCAACGCCCACCTTTGGCGTCTTGCGTGAGCCTGGAGGGGAAAGGGTGCTGAGTGTGGGGTGCAGGGTGGGTTGAGGTCGAGCTGGCATGCACCTCCAGAGAGACCCAACGAGGAAATGACAGCACCGTCCTCTCCTTCTTTTCCCCCACCCACCCATCCACCCTCAAGGGTGCAGGGTGACCAAGATAGCTCTGTTTTGCTCCCTCGGGCCTTAGCTGATTACTTAACATTTCCAAGAGGTTACAACCTCCTCCTGGACGAATTCAGCCCCCGACTGAGGGGAAGTCGATGCCCCCTTTGCGAGTCTGCTAACCCCACTTCCCGCTGATTCCAAAATGTGAACCCCTATCTGACTGCTCAGTCTTTCCCTCCTGGGAAAACTGGCTCAGGTTGGATTTTTTTCCTCGTCTGCTACAGAGCCCCCTCCCAACTCAGGCCCGCTCCCACCCCTGTGCAGTATTATGCTATGTCCCTCTCACCCTCACCCCCACCCCAGGCGCCCTTGGCCGTCCTCGTTGGGCCTTACTGGTTTTGGGCAGCAGGGGGCGCTGCGACGCCCATCTTGCTGGAGCGCTTTATACTGTGAATGAGTGGTCGGATTGCTGGGTGCGCCGGATGGGATTGACCCCCAGCCCTCCAAAACTTTCCCTGGGCCTCCCCTTCTTCCACTTGCTTCCTCCCTCCCCTTGACAGGGAGTTAGACTCGAAAGGATGACCACGACGCATCCCGGTGGCCTTCTTGCTCAGGCCCCAGACTTTTTCTCTTTAAGTCCTTCGCCTTCCCCAGCCTAGGACGCCAACTTCTCCCCACCCTGGGAGCCCCGCATCCTCTCACAGAGGTCGAGGCAATTTTCAGAGAAGTTTTCAGGGCTGAGGCTTTGGCTCCCCTATCCTCGATATTTGAATCCCCAAATATTTTTGGACTAGCATACTTAAGAGGGGGCTGAGTTCCCACTATCCCACTCCATCCAATTCCTTCAGTCCCAAAGACGAGTTCTGTCCCTTCCCTCCAGCTTTCACCTCGTGAGAATCCCACGAGTCAGATTTCTATTTTTTAATATTGGGGAGATGGGCCCTACCGCCCGTCCCCCGTGCTGCATGGAACATTCCATACCCTGTCCTGGGCCCTAGGTTCCAAACCTAATCCCAAACCCCACCCCCAGCTATTTATCCCTTTCCTGGTTCCCAAAAAGCACTTATATCTATTATGTATAAATAAATATATTATATATGAGTGTGCGTGTGTGTGCGTGTGCGTGCGTGCGTGCGTGCGTGCGAGCTTCCTTGTTTTCAAGTGTGCTGTGGAGTTCAAAATCGCTTCTGGGGATTTGAGTCAGACTTTCTGGCTGTCCCTTTTTGTCACCTTTTTGTTGTTGTCTCGGCTCCTCTCGCTGTTGGAGACAGTCCCGGCCTCTCCCTTTATCCTTTCTCAAGTCTGTCTCGCTCAGACCACTTCCAACATGTCTCCACTCTCAATGACTCTGATCTCCGGTNTGTCTGTTAATTCTGGATTTGTCGGGGACATGCAATTTTACTTCTGTAAGTAAGTGTGACTGGGTGGTAGATTTTTTACAATCTATATCGTTGAGAATTC MOUSE SEQUENCE -CODING (SEQ ID NO: 9)ATGTTTCAAGCTTTTCCCGGAGACTACGACTCCGGCTCCCGGTGTAGCTCATCACCCTCCGCCGAGTCTCAGTACCTGTCTTCGGTGGACTCCTTCGGCAGTCCACCCACCGCCGCCGCCTCCCAGGAGTGCGCCGGTCTCGGGGAAATGCCCGGCTCCTTCGTGCCAACGGTCACCGCAATCACAACCAGCCAGGATCTTCAGTGGCTCGTGCAACCCACCCTCATCTCTTCCATGGCCCAGTCCCAGGGGCAGCCACTGGCCTCCCAGCCTCCAGCTGTTGACCCTTATGACATGCCAGGAACCAGCTACTCAACCCCAGGCCTGAGTGCCTACAGCACTGGCGGGGCAAGCGGAAGTGGTGGGCCTTCAACCAGCACAACCACCAGTGGACCTGTGTCTGCCCGTCCAGCCAGAGCCAGGCCTAGAAGACCCCGAGAAGAGACACTTACCCCAGAAGAAGAAGAAAAGCGAAGGGTTCGCAGAGAGCGGAACAAGCTGGCTGCAGCTAAGTGCAGGAACCGTCGGAGGGAGCTGACAGATCGACTTCAGGCGGAAACTGATCAGCTTGAAGAGGAAAAGGCAGAGCTGGAGTCGGAGATCGCCGAGCTGCAAAAAGAGAAGGAACGCCTGGAGTTTGTCCTGGTGGCCCACAAACCGGGCTGCAAGATCCCCTACGAAGAGGGGCCGGGGCCAGGCCCGCTGGCCGAGGTGAGAGATTTGCCAGGGTCAACATCCGCTAAGGAAGACGGCTTCGGCTGGCTGCTGCCGCCCCCTCCACCACCCCCCCTGCCCTTCCAGAGCAGCCGAGACGCACCCCCCAACCTGACGGCTTCTCTCTTTACACACAGTGAAGTTCAAGTCCTCGGCGACCCCTTCCCCGTTGTTAGCCCTTCGTACACTTCCTCGTTTGTCCTCACCTGCCCGGAGGTCTCCGCGTTCGCCGGCGCCCAACGCACCAGCGGCAGCGAGCAGCCGTCCGACCCCCTGAACTCGCCCTCCCTTCTTGCTCTGTAA HUMAN SEQUENCE - GENOMIC (SEQ IDNO: 10)CACTAAGCACTCTCACCACCCAATGCCTGGAGTGGTTGTAGTCAGTGAGTGACACATTGCACAGTGTGTGCCCCCTGGATTGGGGGTGGGTGAGAGACAGCCCCCACAGTGAGTGGCACCCCTGGCCAGGGCCTGGGACAAGTCTGTATCCAAGGGTGGCTCTCTGCTTAGGTCTGTGTTTGTACCTGGGTGTGTCTGTGTCTGCCCTACTCTGTGCATACTCATATATGTGAACCCGTGTGTGTGTGTGTAGTTGTGAGTGTGTGTGGAAGAGGCTGCATGGCAGTGGAAGCTAGGTGTGTGATTCGTGTATCTGTGTGCCTAGAGTGCCTTGTTCTATAGATTTGGATGCCACTCCAAGCAAGTCAGTGGGTCTTTTTGTTTTTTGTTTTTTGAGATGGAATCTCACTCTGTTGCCCAGGCTGGAGTGCAGTGGCACGATCTTGCCTCACTGCAACCTCTACCTCCTGGGTTCAAGTGATTCTCCTGCCTCGGCCCCCCGAGTAGCTGGGATTACAGGTGCCCACCAATACACTCAGCTAATTTGTTGTATTTTTAGTAAAGATGGGGTTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCATGATTCTCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGCGCCCGGCCAAGTCAGTGGGTCTTTAGGAGCTGTTTCGTACGGTGTGACTGTGAGTGAACCTTCGCACACGTGTCTGTACGGATATCTAAGAAATTCTTCAAGTAGGCCGGGCACAGTGGTTCAGGCCTGTAGCCTTAGCACTTTGGGAGGCCCAGGTGAGTGGATCGCTTGAGCTCAGGAGTTCGAGAACAGCCTGGGCAACATAGTGAGACTTCGTATCTATAAAAAATATGAAAATTAGCCAGGCATGACAGTGGGCACCTGTAGTCCCAGCTACTACTTGGGGGGCTGAGGCAGGAGGATCCCTTGAGCCTGGGAGGTGGAGGCTGCAGTGAGCTGAGATCGAGCCACTGCACTCCAGCCTGGGCGACAGAGGGAGACCCTGTCTCAAAAAAAAAGAAAAGAAAAGAAAAAAACAAGACATTCTTCAAGTCCACAACTCTGAGGGTATCACTGTGAGAGCAGGGGTCCTAGCTCTACCCATTTGTGTGTGTGTGGAGATGTGTAAGTCTATGTAGACAAAAGTGTGTGTCATTTACTGTGTTTGGGGTGTGAACACCTATGTGATGTGTTTGCACAACTGCACGTGTTTTGTTCTGTGTGTGTGATCGTGTGTTCAAATAAGTCATCTTGTCGCCGGGCGTGGTCGCTCATGCCTATAATCCCAGCACTTTGGGAGGCCTAGGCAGGAGGACCATTGAGCCCAGGAGGTCCAGACTGCAGTGAGCCGAGATTGCGCCACTGCACTCCAGCCTGGGCGACAGCAAGACCTTGTCTCAAAACAAAAGCAAAAACAAAAATAAACAAATAGTCATCAGGTGCCTGCACAGACAAAGGTGAAAGGTCTCTCCCTGTTGAGATCTGTGGATAGGGTGTATATATGCACATCTCACCCTCTCTACGTGTCTATCTGTCTCTGTCCTCACGGCAAAAGAGAGGTTGGCCGGGTGTGTGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGCGGATCACCTGAGGTGACGAGTTCAAAACCACCCTGGCCAACATCGCGAAACTCCATCTCTTCTAAAAATACAAAAAAATTAACCCCCCGTGGTCGCACACGCTTGTAATCCCAGCTACTCAGGGAGGCTCAGCCATTAGAATTGCTTGAACCCAGGAGGTGGAGGTTGCAGTCAGCCAAGATTGCGCCACTCGACTCCAGCCTCGCCAACAGAACAAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAAAAGAGGCTCAGATATGTTTCTGTCTGAGAGTCTGTCAGAGTTTAGGAATTACTAAATGAATGAATGGTGAAGATCCATTTACTCAACAAACATTTATTTATTTATTTATTTATTGACACAGAGTCTCCCTCTGTCACCCAGGATGGAGTGCAGTGGCGCAATCTCCGCTCACTGAAGCCTCTGCCTCCTGGGTTTAAGAGAGTCTTGTGCCTCAGCCACCAACTACCTGGGATTACAGGTGTGTGCCACTCCCCCCAGCTAATTTTTGTATATTTAGTAGACATCCGGTTTCACCATGTTGCCCAGGCTGGTCTCGAACTCCTGCCCTGAAGTGATCTGCTCACCTCAGTCTCCCAATATCCTGGGATTACAGGCATGAGCCACCAGTCCTGCCTCATTTATTCTTATATTATATTATATTGTTTTTATTTTAAATTTTTTTGTAGTGACAGGGTCTTACTATGTTGACTGGGCTGGCCTCAAACTGGCCTCAAGTGATTCTCCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGTGCCTGGCTTGAACAAATATTTAATAACCACCTATTCGGTACCACCTGCTATGCTGGGGACAAGGCAGTGACCGGGATGGTTTTGGCCGAGCTTTCACCCAGCTCACAACCCAATGAGGGAGACAAACCTATCCCCAGACAATGATGACCCCAGATTGGCAGAGTTGGAGGGAGGGACCCCAGGAGACGCGGCCTTGACTCAGCCTGGAGATCAGGGAGGGCTTCCTGGAGGAGAGGTTATGGGAGTTAAGACTTGGAGGAAAAGACTATGAGCCACAGGAAGCGAAGGGAAGAGTGACCCAGGCAGAGGGAAAAGCACCTGCAAAGGCCTGAAGTCCAGGGAGAGAGGCCAGGCATCTGGAACACAACGGGGAGAGGAGAGACGAGACTAGCGCACCCTCGGAGCAGGTCGTTCAGGGCCTCACGAGCCATCGGGAGCAGTATAATGCAGGATGCAGGGGTACTGGGAGGGTCAAGCTAACAGTGTCCAATCTGGGTTACTCTGCTTCCCTGAAACTCCAGGGACATCTCCTCCAGGAAGCCCTAGGGATTGCTCAGTGTGGAGCCGCTCAGCCACCCAGTCACACTCACTATTCAATGCTGAGCACTGAGGAGGCAGCCGTTACTAAATCAGCCTGGATTTGCCCTCCCAGAGGTCACAGTCACAACAGTCAAAACACACACCTGCACGTGCACACTCATGAACGTCCCCCTCCCCTCCTCTGGAGCCTCAGAACCCACAGACCTTGTTCCTCCCAGGGGGTGTCCCTGGGGCCAAAGCTTCTGCACTACCAGGGGGCTTGTTGGAAATGCAAAAGATGGCTGGGCACAGTGGCTCACACCTGTAATCCCAGCAGTTTGGGAAGCTCAGGCAGGCACATCATTTGACGTCAGGAGTTCATTTGAGGTTGGGAGTTCAAGACCAGCTTGGCCAACATAGCGAAACTCTGTCTCTACTAAAAATACAAAAAAATTAGCCGGGCGTGGTAGCACACGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCTTTTGAACCCGAGAGGTGAAGGCTGCAGTGAGCCAAGATGGCACCACTGCACTCCAGCCTGGGTGACAGAGTGAGTCTTAAAAAAATAATAATAAAATAGGCTGGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGACCAAAATAGTGAAACCCCGTCTCTACTAAAAATACAAAAAAATTTAGCTGGGCGTAGTGGCTAACGCCTGTAATCCCAGCTACAGGCTGAGGCAGGAAAATTGCTTGAACCCAGGGGTGCAGAGGTTGCAGTCAGCCAAGATGGCACCATTGCACTCCAGCCTGGGCAACAACAGTGAAACTCCGTCTCAAAAAACAAAATACAAAAATTAGCCAGGCATGGTGGCACACACCTCTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCACTTGAACCCGGGAGGCAGAGGTTGCAGTGAGCTCAGATCGTGCCACTGCACTCAAGCCTGTGTAACAAGAGTGAAATTCCGTCTCAAAATAAAATAAAATAATAAAAATAAAAAGATGACCACAGCAGATCTGCTGGCTCTCCAGGCAATTCGTGATCACCACGAATTGAGAAGCGCTGCTCTCAGGCTTAACCCCCCTGTACCTCAGTTTCCTTTTCTGTACAAGGAGATCAAAACAGAATCCATGTAGAGCACTGACGTGGACTCAGGCTTAACTGAGATAATGAGTGTGAAAGTGCTAAGCACAGCTTCCTAAGTGCTTGTTTTCAGCACCTCCTCTTCCTCTTTTCTATTTTTTTATTTTTATTTTTTTTGGGGGGGGAACAGGGTCTCGCTCTGTTCCCCAGGCTGGAGTATAGTGGCAGAGTCATACCTCACTGCAACCTCAATCTCTCAGGGCTCAAGTGATGCCCGTGCCTCAGCCTCCTGAGTGGCTGGGACTACAGGTGTGTGCCACCATGCCCAGCTAATTTTTAAATTTCTTGTAGAGCTTGGGGGTGGGTCTCACTATGTTGCCCAGGCTGGTCTTGTACTCCTGGCCTCTGGCGATCCTCTTACCTAGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCACACCCAGCCCTCCTCCTCCTCTGTATTATTAAATTTCAGAGCTGGAAAGAAATTTCGAAGACCGCCATCACTCAACCTTCTTGCTCTACAGATGGGGGAACTGAGGAACACAGGAGCAGAGGTTTGGCCAGAGGAAGGTGGGAAGGACGTGGTGTGCCTGGCCTTCACAGACTCTGCCGGGGCCTCTTTACAGGATACTCTGAGGAAAGCCACGATGGGCACTGATACCCACCTCCACCCTGCGGGAGGCAGAAGGCTAAGGCTCCCCCAGCCGTCTCCCCCAAGCAGAGCTGAGCCCTTGGGAGCCAGCCCAGAGATGCAACCCTCTCCCCCATGCTCAGGTCCTCCTCCTCCTGGAAGCTCTCCTTCCAAGAGGAGCCTCTTATTTTATTTTTTATTATTATTATTTTTGAGACAAGGTCTCACTTTCTCACCCAGGCTGGAAGTGCCGTGGCATGATCATGGCTCACTGAAGCCTTCCCCTCCCCAAGCTCAAGTGATCCTCTCACCTCAGCCTCCCAAATAGCTGAGACTACAGGCACACGCCACCACCCCTGGCTAGTTTTTGTATTTTTAGTAGAGATCGCCTCTTGCCATTGTCCAGGCTGGTCTTGAACTCCCGGGCTCAAGTGATCTGCCCACCTTGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGACACTGAGCCTGGCAAGGAATGAGCCTTATGGAGAAGAACTTGATTTACCCACTCCATGCTCTGCAGGCAGGTGTGTCATGTCTGTGAGTGCAGGTGTGTGTGTGTGTGTGTATGTGTGTGTGTGTGTGTCTCCAGGGCCAATTTCTCCCTTAGGCCCAGGGGCACAGTGCCTAGGGCCCATGATAAATTTAACCGACCCACGGATATGGGTCAGGAGGGTATACATGTATAAAGTTCAGGAAGACTTTCTTTTAGTAACAAAACGAGCATGTACAATCTGTCAGGACCCTTATGATATCTTCCCACCAGTCTCATGACTGGGCACTACATCTTGTTCTCCTTTGTCGGGTAGCCAAACTGAGGCCCCGGATGTCCTAGCTCAAGTTCACCAAGCTACTTCGTGATAGAAGCGGAACATAACCCTAGGCCACCTAGCTTCTGGGTCTGCGATCGTCTGAGGATAAATGCCCAGTGTGTTCGTGAACATGAGCATCCCTGTGTGAATAAATTGACATACATAAACCCATTTAATAAATTTCAAAGCCAGGCGCCGTGGCTTACTCCTGCAATCTCAGCGCTCTGGGAGGCTGAGCTGGGAGCATCGCTTGAAGCCAGCAGTTTGAGATCAGCCTGCAACAAAGTGAGACCCTGACTCTAAAAACATTTTTTTGAATAAAAAAATTAGGCTGGACACAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGTGGATCACTTGAGGTCAGGAGTTTGAGACCAGCCTGGTCAACAGGGTGAAACCCTTTCTCTACTAAAAATAGAAAAATTAGCCAGGCGTGGTGGCACATGCCTGTAATCCCACCTACTGGGGAGGCTGAGGCCGGAAAATTGCTTGAATCTGGGAGGTAGAGCTTGCAGTGAGCCAAGATCATGCCATTGCACTCCAGCCTGGGCGAAGAAACGAGACTCTGTCTCAAAAAAAAAAAAAAAAAATTAGTCAAGCATGGTGGTACCCACCTGTAGTTGTTAGTTACTTGGGAGGCTGAACCAGGAGGATTACTTGAGGCCAGGAGTTCGAGGTTACAGTGAACTATGATTGCATCACTGCACTCTAGCCTGGATGACAGAGCAAGATCCTATCTCAAAATAATACTAATAGTTCAAGGAACAGACTTTGAAGCCTGACACCCTGCATGGTGTTATTCCAGCTTTGCTACTTACTTGCTGTGTGACTCTGGGTGAATAACTTAACCTCTCTGGGCTTCTGTTTCCCTTCCTGTAAAATGATCATTTGTACCTCACAGGAGTGTTGTGAGAATTAAATAAGTTAATATAAGCTCTTGGGAAGAATTAGCTCTTGTTATGGTTGTGTGAAGAGCTTTACACCAGTCCCTCTGCAGGATGCATGGTTGTTGGTCTGTGTGTGTGTATATATATATATGTGTGTGTCTATGTGTGTATCTATGTGTATATGTGTATATGTGTGTGTTGCTCTCTTGATCTCTGAGTGTTGTGTGTGTGTCAATGTGTGAGATCATATATGCACCTTTAGTAAAGATCTAGGGGTCTCTGTGTGTTTTCGCGGTCTGTACCTGTCCTTGGCTGTACACCTGAACCCTACGTCTTCTTGTGTGTGTAGGGATGTCTGTCATGTGTGTTGATAACCATATGACAGTGTCTGTTTCCACATGCCAGTGTGTGTCTGTGAAGCTCTTTCTATGTGGCTGTGGGTGATTGCCCACGCGTGACCTGGTGAGCGGCTGTGTGGAAGTCTGTGTTGCCTGTGTCGGCTGTGGAGTCTCTCGCCAGCCAGGCTAGCTCTTTGCATGTTTCCTTTATTCCATGGAGGAGCAGATGAGGGGCTTGGATGAGACAGAAGAATGAGGGGTCACTCCCTGTCTGATGCTGGGGCCGAGTCACTGCCTACTAGTGGCTGCTGTGTCATCTCCCAGTCTCTGTCCCTCCCTCCTGGCTGGTGGCACACACAGCGGGCGTGGAGGAACAGGGCAGGGGGTGCGCTTGAGGCTGGACTTTTGTCTGGAAACTTGAACCTCCACCTATGCCCCCCACGTCCCTCTAGTCTTCCACATCTCCCTACACCCTCCCTACTATTGGGGCAGGGAATCAGGACTCCCTGAAAATTAAGAACCATCGCCTTGGCTCTGCCACAGGCTTGCTGTGTAGCCCGGAGACAGGCCCTGCCCCTCTCTCAACCTGTGAAATTCAATGTTTTAAAAGTGCTTCTTCCTTTGTGCCCAGGGCTGGGCCAGGCTGTGCACTGGGAGGGAAGTCCTGGGTTCTCTGAGGTTTGTGAAATAGCTGCTAGCACCCTTCCCAGTGGGTCCTTAAGAGTTGGGGGCTGTAGCATCTGAAATACCCAAGTCAGTGCAGGCATAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGACCGAGGCAGGCGGATCACCTGAGGTTGGGAGTTCCAAACCAGCCTGGCCAACATGGTGAAACCCCCATCTCTATTAAAAATACAAAAGTTAGCCCGGGCACACTGGCTTACCCCTGTAATCCCACCATTTAAGAAGGCCAACGCCCCACGATCACCTCAGTTTCGGAGTTTGACAGCAGCCTGACCAATATGGAGAAACTCTGTCTCTACTAAAAATACAAAAAAACTACCCAGGCATGGTGGCACATCCCTGTAATCCCAGCTACTCGGGAGGCTGAGGCACGACAAGCACTTCAACCCGGGACGCGCAGGTTGCGGTGAGCCGAGATCGTGCCATTGCACTCCAGCCTGCCCAACAAGAGCAAAACTCTGTCTCAAAAAACAAAACAGAACAAAACAAAAATTAGCCAGGTGTGGTGGCGCACACCTGTAATCCCAGCTACTCCGGACGCTGAGGCAGCAGAATCACTTGAACCCAGGAGATGTAGGCTGCAGTGAGCCGAGATTGTGGCACTGCACTCCAGCCTGGGCAACAGAGTGAGACTCTGTCAAAAAAAAAAAAAAAAAACGTCAGATTCATGAACCCCATTTGCTAAGAAGATTTGCTCAGGTAGTCACCTGTACCCCTGTGAGCCAAGATTGCAACAGTACATGCTAAGAGCACTAACAAGCACTTTGTAAAGCTTAGAAAGACCTGACAGGCCAGGCGCTGTGGCTCACGCCTGTAATCTCGACACTTCGGGAGGCCGAGGCAGGCGGATCACCAGGTCAGGAGTTCAAGACCATCCTCACCAATATGGTGAAACCCCGTCTGTACTAAACATATAAAAATTAGCTTCACGTGGTGGCCCGCGCCTGTAGTCCAGCAACTCGAGAGGCTAAGGTGAGGCGGAGGTTGCAGTGAGCCCAGATCGCCACTGCACTCCAGCCTGGCGGCAGAGCAAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAGACCTGACAAGTGAAAGCTACTAATATTGCCATTATCATTTAAAAAAACCCCAGACACAGGTTTTTCAGGGAGTTTCATCCAACCAGGCAGGTCTCAGAAATCAGAAAAGAAATGGAAACCGTAGCAAATCTGGAGTTTGACAATTCTGAGTTTGAATTTCTTGTGATGGGATCTTGGGCAAGTCATTTAACCTCCCTGAGTATCATTTTTTTCTTTTATAAAATGAAGATTTTTCTCTCTTAACCTTCCACAGCTGTTTTAAGGATTACAAATCTTCTACTGAAAGGCGTAGCACACGAGCTGTGCTTGGCAAGTGCCAAATACAAGGCATTAATTATTATTATTAGAATTAATAATAATATCCCCTCCCTCTTACACATTCTTTGTCTCCGGGTGGATTAAAAGGTGGAACCAGACCCTACCAACACCATCAGAAGAGAGGCTTCTCTCTAAGTTTCATTTCCCATCTCCTCCAAATCCGCATCCCTCCCAAACGCCGGACCTGTAAGGCCAGCAGGGTCCAAGACACACATCCTTTGCCCAGCGGGGAAGATTAAAGCTAAAGCTCAGACAGCGAAAACATTTCCTAAGCTCGCACAGCCAATCAGGACAGAAACCAGGACGAGCCTCGGAATCCCTCCATTACCTCCACTTTCACCTGAGCATCACAGCCCCCTCGGGACTCAGTTTCCCCACCTACGTCACCACACCACACTAATCAGGGTCTCCTTTTGGAGATCTGCTCTTCTTCTCGAATGGGGGCGCTGCACCATCCGTAGAACAGGGTAGGTGGGGGCGCCAGAGGTGAAGGGGACCTCCAGCCTGGGGTCTTCCCCGCCCGCGTCAGCGGGGTCCCTGCGCGGCTAGTCTAAGCGCCTATTATTACCAGCCCCCGGGGCGGCGTTGCACTGCGCAGGCCCGCGCGGGGCGCGGGCGCGCGCCCGAGCGAGCGAGGGATTCCCTCTGACGTCATTGCTAGGATACCAAACAAACACTCCGCCGCGCCGGCCGAGCTCCTTATATGCCTAATTGCGTCACAGGAACTCCGGGAAGGCCGGGCCGGGATCCCCTCCCGCCGAGTGCCCCGGAACGCAACCCCCGAGACCCCCAGGGCCCCGAGGGTCATGCAAGTGACCAGATCGAGTCTAGAACAGACCTCTTGCTGGACAGTGCGGGACTCGATTTGGCGGGGCCCGACATTTGGGGAAGTTTGTCCAGCAAGGGGCGGGTGACGTAAGCAGGGGGGCGGGTCCCGGGCATATAAATACAGCCTGGCGGGTCTGTGCTTCATTCATAAGACTCAGAGCTACGCCCACGGCAGGGACACGCGGAACCAAGACTTGGAAACTTGATTGTTGTGGTTCTTCTTGGGGGTTATGAAATTTCATTAATCTTTTTTTTTCCGGGGAGAAAGTTTTTGGAAAGATTCTTCCAGATATTTCTTCATTTTCTTTTGGAGGACCGACTTACTTTTTTTGGTCTTCTTTATTACTCCCCTCCCCCCGTGGGACCCGCCGGACGCGTGGAGGAGACCCTAGCTGAAGCTGATTCTGTACAGCGGGACAGCGCTTTCTGCCCCTGGGGGAGCAACCCCTCCCTCCCCCCTGGGTCCTACGGAGCCTGCACTTTCAAGAGGTACAGCGGCATCCTGTGGGGGCCTCGGCACCGCAGGAAGACTGCACAGAAACTTTGCCATTGTTGGAACCGGACGTTGCTCCTTCCCCGAGCTTCCCCGGACAGCGTACTTTGAGGACTCGCTCAGCTCACCGGGGACTCCCACGGCTCACCCCGGACTTGCACCTTACTTCCCCAACCCGGCCATAGCCTTGGCTTCCCGGCGACCTCAGCGTGGTCACAGGGGCCCCCCTGTCCCCAGGGAAATGTTTCAGGCTTTCCCCGGAGACTACGACTCCGGCTCCCGCTGCAGCTCCTCACCCTCTGCCGAGTCTCAATATCTGTCTTCGGTGGACTCCTTCGGCAGTCCACCCACCGCCGCCGCCTCCCAGGTAAGTTTTTGATAGTAGGCGTGCTGCTTTGTAGGTTTTATTTTTTAAGTCAAGGGTGAAAAGAATAAACCCCAACCCCCACAAAAAGGCGCATCAGAACCCTAGATCTGAGATGGAAAAGGCTCACAGCGCACTTTGCAAACTGCAAAGAGTCGGGAGATGTTTGCAATTGGTTGCGTCCGTGGAGCGCAAGGAGGGAACGCGGCAGGGAGGGTAGGCTTTGGGGCGAGGTGGGGGTCGGCTCCGTAATGCGCTGCTCAATGCAACGTGTATGCGGTAGCGGGGCTGAGAACTTTGAGCCGGCCCCGGGACTGCCCCCTGCTCGGGTCCCAGACCTGAAGCTAGCGCAGTTAGGCAGGTGGGGGAAATCCCGGGGAAGCTTCCAGCAGTCTCTTTTCCTTTCCTCCTCCTTCGGAGCGCCCACTTCGGTGCCGGGTCGCCCTCCACCCATCGGGAAGAGGGGCCTCGAACCCTCAGCCGCGCTGCCTCCGCCTCCTGCGCGGAGACGTAACGGGGCACCCGTGCGTAACGGCTGACGCGCTGGAATCCTCCGTCTGACGCGGGGCACGCACGCCGCGCCGCGCCCCCTTCGTCCGCCCCGCCCCTGACGTCCCGCGAGCGTTCTATTTTGGAACGCCGGGGCCACGTTGCTAAGGGAGGGGGCAGCCCGGCGTTTCGATTGCCCGCCGGGGCGCACGCCTTGGCCAATCAGCTTTCCCTTCCTATTTCTAGGGTGCATTTTCCTTCCCCCCTCTCTGTCCCCGGAACCCGTGGTTCCTTGGCGCCTGGGTCTCTTTTCGGCCCCTCTAGAGGCAGAGGGAGGGGATCCCTGTCGTGACAAGAGCGCCTGTCTGCGACCCAATGGATCTGCGAGGCCCTTGCGGGCATCTAGTCCCTGGGCTCTCAGGAGAAGGGGGTGTCTGCTTGTGTGCTGGCGTTTCTTGGAGAGATACGGTCGCTGTCACCCTCTTCTCCAGGCACACACAGACACATTCCCACTCCCTCTGCTCCTCATCCCCGGTTCCTCCGGTGTGTCCCAAGACAGGACTAGAACCCCCAACCGAAGGGCAACCAGCCAGGTGGTCTCCAGGAGCTCCGCCCCCTCTGGGTTCCCAGGACTCTGATTGCTCGGCGACCCAGCCCTTCCCTCACCACGCCCCCCGAGAGAGTAGTTAAGCCTTCACACCAGTTCCAGGAGTCCATTTACGGGAGGGGGGAGATGAGCGCTGCTGAGGCTTGGGGGCTCAGGTCCCGCACCATTCCCCCTCCGCGACAATCTGAGAGAGCTCCAGTGGTTACTTTTATCTACCTGTCCGTTCACCCTAAACTGTCACTCGTCAGTCTCACTCTGAGAAGAGACAGTAACTTGAAACGTTGTTCTAAACTCCTAGGCCCGTCCCCCAAACACCCTTTTGACTGGGACCCCCGCCCCTGCATGGGACCTCGCGCAGAGGGGGGTGTCTATGTGTGTGAGTGTAGAGGAAGGCTTGGCCTAAGGCCTCTCCTTCTCCCTCCCCTTGCCTCTGGGGTGGGGGTGGGGTGTTGTGGCTGTGTGTGTGGCTGTGGCTCCGTCCCGGGGGTTCTGTCACCCGGCTGTGTCCAGCCTCCTCTCCACCCCCCATACCTAACACTCACCAACCCGGGGTGTGATTCACCACCCGCTGGAACCGTGCAACCTTTCCCCGAGGAAGAAGGAGGAGGTAGAAGCCAGTTGAGCAGAAATCCTCTCATTAACCACTGCGTCACCGTGTAGTGGAAGGGTGGGTGTTGTGGCTTTTTCCCTGTGACACACACATCCACACTCCCTCACCCTGTGCTCACTCACGGGGTCGGTGTGTCTTATGTGTGTTGGGTCTGTGTGTGTCGGTGTCTTTGTTTGTGTGTCTACGCCTGTGTCTGTATCTGTCACCCCGTAGGAGTGCGCCGGTCTCGGGGAAATGCCCGGTTCCTTCGTGCCCACGGTCACCGCGATCACAACCAGCCAGGACCTCCAGTGGCTTGTCCAACCCACCCTCATCTCTTCCATGGCCCAGTCCCAGGGGCAGCCACTGGCCTCCCAGCCCCCGGTCGTCGACCCCTACGACATGCCGGGAACCAGCTACTCCACACCAGGCATGAGTGGCTACAGCAGTGGCGGAGCGAGTGGCAGTGGTGGGCCTTCCACCAGCGGAACTACCAGTGGGCCTGGGCCTGCCCGCCCAGCCCGAGCCCGGCCTAGGAGACCCCGAGAGGAGACGGTGAGTAAGGGACATCAGAACTTGGCCTGGGTAGGGGGAAGCAAGAGAGGCAGGAAGTTTCTTATGAATGGAGGGGGGCTCCACTAAGGCCTCAGTGTTACAGAAACCCCAAGATCCTTGCTACACGAGCGAGGACCCCAGGCTTGTTTTTTGGCTCTTGGGGGTTCTGAAAGAAGTAGAGGTTCGGGATCCCTCCACGAGTGCTGTATCCCCAAATCTCATGGCCTCTATCTCCCTGACTCACCTCACCCCACAGGAAGAGGAGAAGCGAAGGGTGCGCCGGGAACGAAATAAACTAGCAGCAGCTAAATGCAGGAACCGGCGGAGGGAGCTGACCGACCGACTCCAGGCGGTGACGACAGGCCCTGGGGTCGGAGAGGGGATGTTGAGGGGAGCTCTCTCCCCATTCTCTGCCCCCTCTCCACCTGTACCCTTATCCTGGGTTGAGAACTAGACGTTCCACACATGGAACTAGGTACTGCTGTGGCCAGACTGGGTAGCCCAGGGCACAAACACAGACCCCCATGCACTTAAGTCAACTCCTGGTCCCCCCCCCATTTCCTGACCCCACCGACTACTCTCCTAGCCTTCATTTCATCCCAAGGGGCCACATGGGGCCCTTGAGGAGAGGGGCGCCCCCATCATTTCTCCCATCTGGTCTTCAGCAAGTAACAACCCATTTTGCCTCAGTTTCTCCATCTCTGCAAACCCTCATCAAATCTCCCGCGCTCTTTCTACCCTTAACACTCTCGAAAGCCTGTGAAATGAAATTATTCCACCTCCTGCCCTACCCACCCACACCTCTCCTGGTGCTGGTGGCATCCCCCAAAACCCACTCCCTTCCTACGTCCTCCCTTGGTCTGAGAGTTCCCTGCTGTATGCCTGCAGGGTGAGCTGTTACTCCTTGAGGGAACAAGGGAATTGTCAACTTTCCTTCTCTACTTTTTCTCTTCCCCGGGAGGTAGAGAGGGAGGGGTAATAGAAGGGAACACATTAAAAACACATAACAGTGGCTCATGCCTGTGATCCCAGCACTTTGAGAGGCCAAGGCAGGAGGATTGCTTGAGCCCACGAGTTTGAGACCAGCCTGGGAAACATAGGGAGGACTTGTCTCTACCAAGAAAAAAAAAAATTAGTTGGGCATCGTGGTGCACACCACTGTCCTCCCACCTACTATGGAGGCTTTACTGCGAGGATCGCTTGAGCCGACCAGGTCCAGCCTCCAGTGAGCCATGATTGCACTATTGCACTCCAGCCTGCGGGACAGAGCGAGACTCTGGCTCAAAAGCAAAACAAAACCAACCACATAACGATTGTTCATTCATTCAACAAAACCTCCTGCACACCAGAAACTTCCCCATAAACTCCCCCCTTCTGTACCATCCTTTCGACACATGGGGGAAACTGAGGTTCCTCCAACCCAACACCCTTGCCCCAACTCCCATGGCCACCACGACTCCATCTCAGCAGCTCTTTTTTCTCAGCCCGCGGCTGCCTTCCAGCAGCAAGTCCAAGGGAGCCATGACCCGAGTTTCCCCCTCACTCACATGCTTTTTTCTCCTTCCTCTCTCTCTTCTGTGACCTGCCCTCCCTGGCCTCAGGACACAGATCAGTTGGAGGAAGAAAAAGCAGAGCTGGAGTCGGAGATCGCCGAGCTCCAAAAGGAGAGGAACGTCTCGACTTTGTCCTGCTGCCCCACCAAACCGGGCTGCAAGATCCCCTACGAAGAGGGGCCCGGGCCGGGCCCGCTGCCCGAGGTGAGAGATTTGCCGGGCTCAGCACCGGCTAAGGAAGATGGCTTCACCTCCCTCCTGCCCCCCCCGCCACCACCGCCCCTGCCCTTCCAGACCACCCAAGACGCACCCCCCAACCTGACGCCTTCTCTCTTTACACACAGTGAAGTTCAAGTCCTCGGCGACCCCTTCCCCGTTGTTAACCCTTCGTACACTTCTTCGTTTGTCCTCACCTGCCCGGAGCTCTCCGCGTTCGCCGGCGCCCAACGCACCAGCGGCAGTGACCAGCCTTCCGATCCCCTGAACTCGCCCTCCCTCCTCGCTCTGTGAACTCTTTAGACACACAAAACAAACAAACACATGCGGGAGAGAGACTTGGAAGAGGAGGACGACCAGGAGAAGGACGAGACACACCGGAAGAGACAAAGTGGGTGTGTGGCCTCCCTGGCTCCTCCCTCTGACCCTCTGCGCCCACTGCGCCACTGCCATCGGACAGGACGATTCCTTGTGTTTTGTCCTGCCTCTTGTTTCTGTGCCCCGGCGAGGCCGGAGAGCTGGTGACTTTGGGGACAGGGGGTGGGAACGGGATGGACACCCCCAGCTGACTGTTGGCTCTCTGACGTCAACCCAAGCTCTGGCCATGCGTGGGGAGCCGGGCGGGTGACGCCCACCTTCGGCCAGTCCTGTCTGAGGATTAACGGACGGCGGTGGGAGGTAGGCTGTGGGGTGGGCTGGAGTCCTCTCCAGACAGGCTCAACAAGGAAAAATGCCACTCCCTACCCAATGTCTCCCACACCCACCCTTTTTTTGCGGTGCCTAGGTTGGTTTCCCCTCCACTCCCCACCTTACCTTATTGATCCCACATTTCCATCGTGTGAGATCCTCTTTACTCTGGGCAGAAGTGAGCCCCCCCCTTAAAGGGAATTCGATGCCCCCCTAGAATAATCTCATCCCCCCACCCGACTTCTTTTGAAATGTGAACGTCCTTCCTTGACTGTCTAGCCACTCCCTCCCAGAAAAACTGGCTCTGATTGGAATTTCTGGCCTCCTAAGGCTCCCCACCCCGAAATCAGCCCCCACCCTTGTTTCTGATGACAGTGTTATCCCAAGACCCTGCCCCCTGCCAGCCGACCCTCCTGGCCTTCCTCCTTGGGCCGCTCTGATTTCAGGCAGCAGGGGCTGCTGTGATGCCGTCCTGCTGGAGTGATTTATACTGTGAAATGAGTTGGCCAGATTGTGGGGTGCAGCTGGCTGGCCCAGCACACCTCTGGGGGGATAATGTCCCCACTCCCGAAAGCCTTTCCTCGGTCTCCCTTCCGTCCATCCCCCTTCTTCCTCCCCTCAACAGTGAGTTAGACTCAAGGGGGTGACAGAACCGAGAAGGGGGTGACAGTCCTCCATCCACGTGGCCTCTCTCTCTCTCCTCAGCACCCTCAGCCCTGGCCTTTTTCTTTAAGCTCCCCCGACCAATCCCCAGCCTAGGACGCCAACTTCTCCCACCCCTTGGCCCCTCACATCCTCTCCAGGAAGGGACTGAGGGGCTGTGACATTTTTCCGGAGAAGATTTCAGAGCTGAGGCTTTGGTACCCCCAAACCCCCAATATTTTTGGACTGGCAGACTCAAGGGGCTCGAATCTCATGATTCCATGCCCGAGTCCGCCCATCCCTGACCATGGTTTTGGCTCTCCCACCCCCCCCTTCCCTGCGCTTCATCTCATGAGGATTTCTTTATGAGGCAAATTTATATTTTTTAATATCGGGGGGTGGACCACGCCGCCCTCCATCCGTGCTGCATGAAAAACATTCCACGTGCCCCTTGTCGCGCGTCTCCCATCCTGATCCCAGACCCATTCCTTAGCTATTTATCCCTTTCCTGGTTTCCGAAAGGCAATTATATCTATTATGTATAAGTAAATATATTATATATGGATGTGTGTGTGTCCGTGCGCGTGAGTGTGTGAGCGCTTCTCCAGCCTCGGCCTAGCTCACGTTGGCCCTCAAAGCGAGCCGTTGAATTGGAAACTGCTTCTAGAAACTCTGGCTCAGCCTGTCTCGGGCTGACCCTTTTCTGATCGTCTCGGCCCCTCTGATTGTTCCCGATGGTCTCTCTCCCTCTGTCTTTTCTCCTCCGCCTGTGTCCATCTGACCGTTTTCACTTGTCTCCTTTCTGACTGTCCCTGCCAATGCTCCACCTCTCGTCTGACTCTGGGTTCGTTGGGGACATGAGATTTTATTTTTTGTGAGTCACACTGAGGGATCGTAGATTTTTACAATCTGTATCTTTGACAATTCTGGGTGCGAGTGTGAGAGTGTGAGCAGGGCTTGCTCCTGCCAACCACAATTCAATGAATCCCCGACCCCCCTACCCCATGCTCTACTTGTGGTTCTCTTTTTGTATTTTGCATCTGACCCCGCCGCGCTGGGACAGATTGGCAATGGGCCGTCCCCTCTCCCCTTGGTTCTGCACTGTTCCCAATAAAAAGCTCTTAAAAACGCATTCGCCAGGCTACAGTGTTTATTTCCTCCTAACACCCATTGCCTGGCTTCCTTTTAGTAAGAGAGGATGAGGTTAGATTGTCGAAGGACTACACACACACAGAGATCATACACCCATGCACACACACACACAGACACACACCTATGCAGGAACTCCTTCTAGTCAATGGGTCTACAGCAGGATAAAAGGAAGGCAGACAGTCAGGAGGACTTCCTGTACTCGCAGGCAGTGCCTCCTACTACAAAAAGTAAGTGGCTACAGCTGGGCGCAGTGGCTTGCGCCTGTAATCCCAGCATTTTGGGAGGCCAAGATGGGCGGATCACTTGAGGTCAGGAGTTTGAGACCAGCCTTCCCAAGATGGTGAAACCCTGTCTCTACAAAAAATACAAAAATTAGCCTGGTGTGGTGGTGCACACCTGTAATCCCAGGCTACTTGAGAGGTTGAGGCAGGAGAATCACTTTAACTTAGGAGGCAGAGGTTGCAGTGACACAAGATTGCACCACTGCACTCCAGCCTGGGTCACAAAGTGAAACTGTCAAAAAAAAAAAAAAAAGTAAGGGGTCAGAAGGTTAGCCTGCAGGTGTGGGATCACAGAGGTCTCCTAGTGATGGAGCTTGTATGCTCTATCGGTTAAAAACAGACGCTAAGGAGATAAACTATACACAGAAGAAGCTTAATGCCCTGTCCACAGTGGCTTGCACTTGCAATCCCAGCTCTTTCGGAGGCCGAGGTAGGAGGCTAGGAGTTCGAGAACAGCCTGGGGCAACATAGTGAGACACCCCCCACCCCAACCCATCTCATTATGTTGAGAAAAAAAAAAAAAAGAGGATCTTGAGAAACTTGCACAGCAAACTACTAAAGACCACTCAGGCTAGGAATGAGGCGTCATCTTGGATTTTTTACAAACTACAACTACAAAAAACAATTATTTTACACTGAAGATGTGTTTCCTTTTGTTTTCCATATGACCACTATTGCGCCCAACCCAAGACTGACTGAAGCAAATATATGACCATTTTTTTTTTTTACACATAGAGTGGAGCCATCCCCATTGCAAAATCCTAGCCGTCTCTTATTTGCATAACAGCAAGTCCTCTGGGAATTGAGGTGAGGGTCCAGCGGTCGCTCACACGCTTTGGTAAATCAATAAGCAAGGGAATTTGTCATGGTGGAATCCATTTATTAATTCACTCAAAAAAATGTGCTAAGCACCTACCCAACTGTGCTGGGAGTTGGGGACACTATAGGGACTGAGCCTCAGGTCTTGCCCTCCTGGGGCTCACAGTCCATTCGGCGACACACACCGTTGCCAGTCAGGGACAACCTAAAGTGGATTGGGTTTCGGAAGCCCATGGGGCTAGGGAAGCACAGCAGGGACACCTACCTTGGACTGGGAGTCGGGAAAAACTTCCTGCCGGAGGGCACAGCTGAGCTGAGTCCTAGAGGAGGATAGAGAGTATAGAAAGAAATAGAAAAAGGCCAAGGCCAAGAAAATAGCACAGCCATAGATCTGTTGGTGGGGACAAGGCTTGATACATTGAGAACGCTTAGAGGGTCGGGTGCGATGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGTGGATCACCTGACCTCAGGCATTCAAGACCAGTCTGGCCAACGTGGCGAAACCCCGTCTCTACTAAAAAATATATATATATATATACAAAAAATTAGCTAGGCATGGTGGTGCCCACCTGTCATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCTGGAAAGTGGACATTGCAGTGAGCTGAGATTGTGCCACTGCACTCCAGCCTGGGCAACACAGCGAGACTCTGTCTCAAAAAAAAAAAAAAAAGAAAGAAAAAAAAGAGAAAACTCAGAGATTCGTGGAGACTGGAACCACGGGTGTGGAGAGAGGGGTTAGTACAGACCAGATTCTGCAGGTACTATAATGACATTCCCAGGCTAAGGAGTTTAGATCTTTTCTTCACGCCACTCCGCAGCTATTGCAGGTTTTGAACACGAGAGGGGCAGGGGCAGGTTTCTCATTTAGGAAAGACCCCTCTGGCCCCAGACTGAGCGTGACTGGAAGGCAGAGCAGTCACACTGAGCAGGAGACCAGGGAGGAAGTGGGGTCGGGACCCTGCACGGTGGGGTGAGGAGGACTCCAGAACAGGGCCAGGGACATGGGACAGAGAGGAGGGCAAGCATTCAGGAGACACTCGGGAGGCAGGACAGTTGGGCTTCGTCAGCAGCCGGCTTGGGAAGGAAAATACAGGGCAGTAATAAATAGCATGGGTCAAGTGGTCTGAGTGAGGCTGGGAGTGGTGGCACGCACCTATGGTCCCAGCTACTCAGGAGGCTCACGTCGCAGGATTGCTTGAGCCTGGAAGTTTGAGGCTGCAGTGACCTATGATCGTACCGCTGCACTCCACTTTCGGTGACAGAGTAAGACCCTGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAGACACTGCCTATGAGTTAACCCTGCTCTACAAGGAGCAGTTTTTAAAGTAAAATTAAAAAAAAAAAAAAAAAAGAAAGAAAGAAAGAAAGAAACAGAGAGAAAAAAGAAAAAAGCCTGGGTTGCCTTCGACAACAGACTTCATCTCCCTGAGCCTCCATTTCCTCATCTGTAGAATGGGGGCTGTTAAGAGGAGTTGCAAGGCTTGTGCATGCCAGCAGTAAGTGCAGAGTGACGGTGCAATTATCATTACCCCCATCATCTTTATTGGGGTCAGCCTGAACCCTCGATATCCCATAATATTCACCCCCATCCTTCAAGGGTCTGCCCTAATGTTCCCATGACACCCGACCACCTCAGCTCTCCTTATGAGAGGGCCTCACTTTTCTATTCCCTTTGCAGCCGTTATCCCCTTTGTAGTTGTTAATTAAGTGTGTAATTACATGATGGCTTAATGTTTGTCTCCCCCACTGGCCTGACTCCACCACGAGACCAAGGCCAGGGCTGTCACCCACCGCTGCGTCCTCAGCAAATGCTTGTTTGATGAGTGAATGACAGATGAACAAATGGGCAAGTATTTGACTGATTAATCACGGCATGCGTGATTAAATAAATGAGTGAGCAAACGACTGAATGAGTAAGCAATTGAAGGGGAGAGATCTAGGATAATTTCCAAACTGCCAATATCCCAGAACTGGGTAGATGACTTTTTCTCCGTCTTTTCGAGTGGGTTTTTATACTCCCCAGCGCGAAATAACTAACGACAATCAGAGATCGGAGTGACACACAATGAGTTTCCGATCCGGAACGCCGCACCCACCTCTCCAGGTGCAGGCTGGAGGAGCGCCTCCCGGGCAACAAGCAAAATAAGTCCCCTTCCATAAGTAACATTCAAGCCCCTTAGTTACTACCGCCCGAAAGGTGGAATTCAACCACTCTCTCGCTACACACCTACAGCTTTGAAGCCTGCACCCCAGACCACTGAGGATCATCCGGGCACCACAACCTTCTTCCCGCGCAGCTATATAACGATCGCAAAAGCTTACCTTTTAGAGTTATGGTCGCCTCCTTTGCAAAGGTGTGAGATGGTTGACTTCAAGGGCTATAAGTTCTCCCCACTCATTTATCGTGAGAGATGTCCTTGTAAAACCTTGCCTTCACTTCATATAGTATGAATCATCCTCGCTCCCCAAACCGTCTCATTTACATAGCCCCACGCATTCTGGCAAGCACCGTTTGAGCACCTGGCAAGCTGTTAAAGGGCCCACGACCCCCTTTTTCCAAAATGAAAACTCAGCTTTTTAAGACGAGAGATTCATGATTCCCCATTCAGAAGCGCCTTCTCGCAAAATTCCGAATTCTCTTTCTGCGGAGGAGTGGTGACTGGGTTCCTGTTACAGTCTGATTCACCCTGGCCCCAAAGGCGCTGAGCACGCGGCTATAGGGCTGGTGCGACACCTGCTGTTCTTTTATGGAATTGCGTAGCCCGATGCAGCTCCCCCTTCATTCAAACCTTTATTGAGCGTCTACTGACTCCCAGGAACTGTCTCGGTGCTCGTGACGACAGACATCCTCTCCCGATTGAGTTTAAACACTACACATAACCAATTTCTGCACTTCCCTTTTATGGTTGGAGAAACTGAGACAGACTCAGAAACGGATAGTACCATATTCCGGTTAAAACAGCCCATCCACTTAGGGAAATCGAACTTGTGTTACAATTTTTATTACAAAAAAGGTGATTCTTTTTTCTTAAATTTTTACATATTTAGGAGCTACAGGTGCCCATTTCTACATGCATATGTTGATTGCATCGTGGTGAAACCTCGCCTTTTAGGTGTACTCATCACGAAAAATTATTCAATATTCTAAGTCAGTGATTCTTTCACAATACCATTCTCCTCCATGAAACTCTCCCATGACTTCCATTTCAGAGTAAAAGTCAAAGTACTCACCCTGCTTTACAAATCCCTGTAATCCAGCCCCTTTGGTCCCTCTGACCCTGTCTCACATACTCCTCTTCCCTTGGATATTATTGGATTTAGGCACACAGATCTCTTGCTGCACACATCGATCATGCTACCACCACAGGGACTTTGTGCTTGCCGATCCCCTAGCCTCGATCTCCTCTTCACATGTTCCCATGGCTCATCGCCTCCCTTCACTCTCTCATCTGATCAAATGTCAATACCAAAAACTCACTGAGTGACCAGCACTCAGTCCGGCCTTCCCTGATCCCAGTTTAAAATAGCGAGTGGCGGCCGGGCGCCGTAGCTCACGCCTGTAACCCCACCACTTTGGGATGCCAAAGCGGGTGGATCACGAGATCAGGAGATGGAGACCATCCTGGCTAACACGGTGAAACCTTGTCTCTACTAAAAATACAAAACATTAGCTGGGCGTGGTGGCGGGCGCCTGTAGTCCCAGCTACTCGGGAGCCTGAGGCAGGAGAATGCACTGAACCCGGGAGGCGGAGCTTGCAGTCAGCTCAGATTGCTCCACTGCACTCCAGCCTGGGGGACAGAGCGAGGCTCCGTCTCAATAAATAATAAATAAATAAAATACCTAGTGGCTGGGATCGGTGGCTCAGGGCCTGTAATCCCAGAACTTTGGGAGGCCGAGGCGGGTGGAtCACCTGAGCTCAGGAGTTCGAGGCCAGCCTGGCCAACATGCTCAAACCCCGTCTCCACCAATGATACAAAAATTAGTCAGGCATAGTGGCTCACGCCTGTAATCCCAGCTACTCGGGAGTTTGAGGCAGGAGAACCGCTTGAACCGGCGACGCAGAGGTTGCAGTGAGCTGAGATCGTGCCATTGTACTCCAGCCTTGGTGAAAAGACCAAAACTCCATCTCCAAATAAAAGTAATAATAATAATAAATAAAATAAAAATTTTTAAAAAGCGACCTCTGTCACTCTATCCCCTTACCCTGCTACACATTTCCCCACCACTCTCATCACCACCTGCCATTTTCTCTGTCTATTTGCTTACCGTCTGTCTGCTTCTCTACAATATCAGCACCATGAAACTATGCACTTTATTTTTGATCATTCCTGTATCTCTAGTGCCTAAAAAGTGCTTGAGAACATAGCAGATGTTCAGTAAATGTTTGTCCAATGAATAAAAGAATATCATCACTGTCTTTTTTTCATTCTTCTTCCAGACAGGATCTTACTTTGTCACCCAGGCTGGAATGCAGTGGCGCAAAAACGGCTCACTGCAGCCTCGACCTCCCAACCTCAAGTGATCCTCTTGCCTCAGCCTCCCTGGGATGACAGGCATATACCATCACGCCCAGCTAATTTTAATTTTTTTTGTAGAAACAGGGCCCTCACTTTGTTGGCCACACTGCCCTCGAACTCCTGGCCTCAAGTGATGCTTCTGCCTTGGGCTCCTAAAGTCCTGGAATTTCACGCGTGAGCCACAGCACCTGGCCTCACTATCCTTCTTTCAGCCTCAGTTTTCTCATTTGTATAACCAGACTAGTACAACTGATCTCACTGGAGAAATCATCATATAAAATTCTGACACTGGCTGAGGCAACTGGGAGGAGCTCAGTAAACGCTCTTTCTGCTGGGCACGGTCGCTCACACATGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGTGGATCACAGGAGATTAGAAGTTCCAGACCATCTGGCAAGCATGGTAAAACCCCATCTCTACTAACAATTCAAAAAGTAGCCAGGCATGGTGGCTCACACCTGTGATCCCAGCTACTCGGGAGGCTAAGGCAGGAGAATCCCTTGAACCCAGGAGGCTGACGTTGCAGTGAGCCAAGATTGTGCCACTGCACTCCATCCTGGGCCACAGAGCAAGACTCTGTCAAAAAAAAAAAAAAAGTTTTTTTTTTTTGGCTGGAATTACAGGCGCCTGCCCCCACACCTGGCTAATTTTTGTTTTTTGTTTTTTTAGGAGACACCCGGTTTCACCATGTTCACCACACTGGTCTTGAACTCCTGACCTCACCTAATCCAACTCCCTCAGCTTCCCAAAGTGCTGAGATTACAGGCGGGAGCCACTACACCTGGCCAATAAAGGCCGTTTCAGTCTTCAATCTGTTTTGAGCTTGGAGGCTTTAGTCATTCCCAGACCCAAAATCTCAATCAGACCCTCTTCCACCACTTTTTGTGATAGATCAATAAACATTTTGTCTTATGGGAAGTTTAACTAAGAGTATCTTTAGAAACTTTTGGACAGGCGCTGTAATCCCAGCACTTTGGGAGGCCGAGATGAGCGGATAGCTTCAGCCCAGGAGTTAGAGACAAGCCTGGGCAACATAGTGAGACTCTGTCTCAAAAAAAAAAAAAAGAAACAAAGGAAAAGAAAAAAAGAAAAAAAAAGTATTCCCTCTGCTTGGCAAATCCAGATTCAAGATATATCCCCTAAACCCTCTTTGTTTTAATTAGATAGTTGCTGCTAGCCACCTCTGTATACAAATTCTGAGGATGTAAGGACTCCTTGGAACACCGTTATCTGTCTCCTAATATGTGACGTGTGTATCACGAACAAGTCAGTTTTTTTTTTTTTTGTTTCTTTTTTTTGGTTTTTTGTTTTGAGACGCAGTCTCGCTCTGTCGCCCAGGCTGGAGTGTAGTGCCGCGATCTTGGCTCACTGCAAGCTCTGCCTCCCAGGTTCACCCCATTCTCCTGCCTCAGCCTCCCTAGTAGCTGGAACTACAGGCCCCCGCCACCACTCCCCGCTAATTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCGTGTTAGCCACCATGGTCTCGATCTCCTGACCTCATGATCTGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTAAGCCACCGAGCCCGGCTTTTTTTTGAGATGGAGTTTCCCTCTTGTTGCTCAGGCTGGAGTGCAGTGGTGTGATCTCGGCTCACTGCAACTTCCGCCTCCCGGGTTCAAGCGATTTTCCTGCCTCAGCCTCCCAAGTAGCTCCGATTACAGGCATGCACCACCACGCCCGGCCAATTTTGTATTTTTAGTAGAGACATGGTTTCTCCATGTTGGTCAGGCTGGTCTCCAACTCCCGACCTCAGGTGATCCACCTGCCTTCCCCTCCTAAAGTGCTGAGATTACAGGCGTGAGCCACTGCGCCTGGCTGCACAAACATTTTAAACGTCAATATTTTTGTGTTTATTTTTACTATTGTCTTATATTTCTGGCAAGCAATACTGGTTTCTGGTGGCAAGGTAACCTTTCTTCTTAAAATACATTTGTTATTATATTATTAAATATTAAACCAATTTTCAAGAAAAATATTAGATAAATACCACAACAGGTTGTAGAAAGATGAAGGTCATGTGGGGAATGACTGAGGTTTGGGAAACAATATTATAACTCCTTACTGTGCATTTATTATATGCCAGGCCCAATGCCAAGGGCTTTACATGTACGTATAGTTATGGTTGACAGTTTTCTTCTTTTTCTTTTCTTTTTTTTTGAAACAGGGTCTTGCTCTGTCGCCCTGTCTGGAGTGCAGTGACGCAATCTCAGCTCACTACAACCTCCACCTCCTTAGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGTGTAGCTGGTCTTACAGGTGCCCACCACCACATCCGGTATTTTTAGTAGGGACGAGGTTTTACCATCTTGCCGAGGCTTGTCTTGAACTCCTGACCTCAGGTGATCCACCTTCCTTGGCCTCCCAAAGGCTGGGATTACAGGTGTGAGCCACTGCACCTGGCCTCTTTTTTTCTTACTTAATTTTTTTGTAGAGATGAGGTCTATGTTGCCCAAACTTGTCTCCAACTCCTGGCCTTAAGTGATCCTCCCTCCTTGCCCTTCCAAAGTCCTGCGATTGCACACGTGAGCCATCGTGCCCGGCCTAATAAGTTTTCCATTTGAGGAAACTCAGGCTTTGAGAGATGAAGTCATATGCTCAAGGTCATACAGCGAAGGGCTAGTAGAGCCACGATTCAAACCCAAGTCTGTGGATCTTTAGACCTCAGTGTTCTCCCAGTCTCCCCACGGGTCCCTTTGCTTCATCCTTTCCGAGTTTAGTTGTCTTTTTTGTTGTTGTTCTTGTTGTTGCTGTTTTTTGATAGAGTCTCGCCCTGTTGCCCAGGCTGGAGTCCAGCGGCATGATCCTGGCTCACTGCAACCTCTGCCTCCTGGGTTCAAGTGATTCTCCTGCCTCAGGCTCCCGAGTAGCTGGGATTACAGGTATGCGCCGCCACACCCAGCTAATTTTTGTATTTTTAGTAGAGATGGAGTTTCATCATGTTGGTCAGCCTGGTCTGGAACTCCTGACCTCAGTGATCTGCCCACCTTGCCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTACGCCCAGTATGTACTTTTTTTGTGTTTTGTTTTTGTTTTTGTTTAGAGACAGCGTCTCCCTCTGTAACTCACGCTGAAGTGCAGTGGTGTGATCATAGCTCTCTGTAACCTCGAACTCCTGGCCTCAACCAATTTTCCTCTCTTAGCCTCCCAAGTACCTGGGACTACAGGCATGCACCACCACGCCCGCATAAATTTTTTTTTTTTTTAGAGACGCGGGTCTTGTTATGTTGCTCAGCCTGGTCTCGAACTTTTCCCCTCAACTGATCTTCCCACATTGGCCTCCCCAACTCTTGGGATCACAGATCTGAGTCATCATGCCAGGCCTCAGATTAGTGTTGAAACTGGAAGTCCAGGGAGGCCCTCTATTTGTTCCCGACGCAATCAGGGTGGGGAGACGTGGGTGGATGAGAGAAGTTTGTGAGGCAGGATAGACACAGCATTGTGACTGATTGTTTGTGCGAGGTGAGTGTGTAGAAGTCCAGAGCCATACCTGGGTGTCTGGCCTGGTGACACCGTGGGCAGTCAAAACATCTCTGAGTTGGAAATCAGGTAGGATCAAGAACACCTTTGGTTAGATTTAGGGTGGAAGGGGCATCCAGAGGCCGTTGGACACGTGGGTTTGGGCTCAGTTGAGGTGGCTGCACAGTAGGCAGGGTGTGGGATCCATTAGTGATGTCTGCCTTGAGCACACGCATGGGAAGTGGCTCCCAAGGCTTGGCTAACCCTGGAATGGTGGGTCTGTCAGCATCTTCCCCTCAATCATTTCTTTCTTTTTTTTTTTTTTGAGACAGAATCTCGCTCTGTCGCCGAGGCTGGAGTGCAGTCGCGCAATCTTCCCTCACTACAACCTCCATCTCCCACATTCAAGCGACTCTCATGCCTCAGCCTCCCGACTACCTGTGATTACACGCATGCACCACCACACCCGGCTAAATTTTGTATTTTTAGTAGAGATGACCTTTCACCATGTTGGCCAGGCTGGTCTTGAACTTCTGGTCTCAACTCATCCGCCCTCCTCGGCCTCCCAAAGTGCTGCCATTACAGGCGTGAGCCACTGCGCCCGGCCTCCCCTCAATCATTTCATAACCTACACAGATGGCAGAG HUMAN SEQUENCE - mRNA (SEQ IDNO: 11)CATTCATAAGACTCACAGCTACGGCCACGGCAGGGACACGCGGAACCAAGACTTGGAAACTTGATTGTTCTCGTTCTTCTTCCCGGTTATGAAATTTCATTAATCTTTTTTTTTTCCCCCGAGAAAGTTTTTGGAAACATTCTTCCAGATATTTCTTCATTTTCTTTTGGACGACCCACTTACTTTTTTTGGTCTTCTTTATTACTCCCCTCCCCCCCTCGCACCCCCCGGACCCGTCGAGGACACCGTAGCTGAAGCTGATTCTGTACAGCGGGACAGCGCTTTCTCCCCCTGGGGGAGCAACCCCTCCCTCGCCCCTGGGTCCTACGGAGCCTGCACTTTCAAGAGCTACAGCGGCATCCTGTGGGGGCCTGGGCACCGCAGCAACACTCCACAGAAACTTTGCCATTGTTGGAACGGGACGTTGCTCCTTCCCCGAGCTTCCCCGGACACCGTACTTTGACCACTCGCTCAGCTCACCGGGGACTCCCACGGCTCACCCCGGACTTGCACCTTACTTCCCCAACCCGGCCATAGCCTTGGCTTCCCGGCCACCTCACCCTGGTCACAGGGGCCCCCCTGTGCCCAGGGAAATGTTTCAGGCTTTCCCCGGAGACTACGACTCCGGCTCCCGGTCCAGCTCCTCACCCTCTGCCGAGTCTCAATATCTGTCTTCGGTGGACTCCTTCGCCAGTCCACCCACCGCCGCGGCCTCCCAGGAGTGCGCCGGTCTCGGGGAAATGCCCGGTTCCTTCGTGCCCACGGTCACCGCGATCACAACCAGCCAGGACCTCCAGTGGCTTGTGCAACCCACCCTCATCTCTTCCATGGCCCAGTCCCAGGGCCACCCACTGGCCTCCCAGCCCCCGGTCGTCGACCCCTACGACATGCCGGGAACCAGCTACTCCACACCAGGCATGAGTGGCTACAGCAGTGGCGGAGCGAGTGGCAGTGGTGGGCCTTCCACCACCGGAACTACCAGTGGGCCTGGGCCTGCCCGCCCAGCCCGAGCCCCCCCTACGAGACCCCGAGACGAGACCCTCACCCCAGAGGAAGAGGAGAAGCGAAGGGTGCGCCGGGAACGAAATAAACTAGCAGCAGCTAAATGCAGGAACCGGCGGAGGGAGCTGACCCACCCACTCCAGGCGGAGACAGATCAGTTGGAGGAAGAAAAAGCAGAGCTGGAGTCGGAGATCGCCGAGCTCCAAAAGGAGAAGGAACGTCTGGAGTTTGTGCTGGTGGCCCACAAACCGGGCTGCAAGATCCCCTACGAAGAGGGGCCCGGGCCGGCCCCGCTGCCCGACGTGAGAGATTTGCCGGGCTCAGCACCGGCTAAGGAAGATCGCTTCACCTGGCTGCTGCCCCCCCCGCCACCACCGCCCCTGCCCTTCCAGACCAGCCAAGACGCACCCCCCAACCTGACGGCTTCTCTCTTTACACACAGTGAAGTTCAAGTCCTCCCCCACCCCTTCCCCGTTGTTAACCCTTCGTACACTTCTTCGTTTGTCCTCACCTGCCCGGAGGTCTCCGCGTTCGCCGGCGCCCAACGCACCAGCGGCAGTGACCAGCCTTCCGATCCCCTGAACTCCCCCTCCCTCCTCGCTCGGTGAACTCTTTAGACACACAAAACAAACAAACACATGGGGGAGAGAGACTTGGAAGAGGAGGAGGAGGAGGAGAAGGAGGAGAGAGAGGGGAAGAGACAAAGTGGGTGTGTGGCCTCCCTGGCTCCTCCGTCTCACCCTCTGCGGCCACTGCGCCACTGCCATCGGACAGGAGGATTCCTTGTGTTTTCTCCTCCCTCTTGTTTCTGTGCCCCGGCGAGGCCGGAGAGCTGGTGACTTTGGGGACAGGGGGTGGGAAGGGGATGGACACCCCCAGCTGACTGTTGGCTCTCTGACGTCAACCCAAGCTCTGGGGATGGGTGGGGAGGGGGGCGGGTGACGCCCACCTTCGGGCAGTCCTGTCTGAGGATGAAGGCACGGGGGTGGGAGGTAGGCTGTGGGGTGGCCTGGAGTCCTCTCCAGAGAGGCTCAACAAGGAAAAATGCCACTCCCTACCCAATGTCTCCCACACCCACCCTTTTTTTGGGGTGCCCAGGTTGGTTTCCCCTGCACTCCCGACCTTAGCTTATTGATCCCACATTTCCATGGTGTGAGATCCTCTTTACTCTGGGCAGAAGTGAGCCCCCCCTTAAAGGGAATTCGATGCCCCCCTAGAATAATCTCATCCCCCCACCCGACTTCTTTTGAAATGTGAACGTCCTTCCTTGACTGTCTAGCCACTCCCTCCCAGAAAAACTGCCTCTGATTGGAATTTCTGGCCTCCTAAGGCTCCCCACCCCGAAATCAGCCCCCAGCCTTGTTTCTGATGACAGTGTTATCCCAAGACCCTGCCCCCTGCCAGCCGACCCTCCTGGCCTTCCTCGTTGGGCCGCTCTGATTTCAGGCAGCACGGGCTGCTGTGATGCCGTCCTGCTGGAGTGATTTATACTGTGAAATGAGTTGGCCAGATTGTGGGGTGCAGCTGGGTGGGGCAGCACACCTCTGGGGGGATAATGTCCCCACTCCCGAAAGCCTTTCCTCGGTCTCCCTTCCGTCCATCCCCCTTCTTCCTCCCCTCAACAGTGAGTTAGACTCAAGGGGGTGACAGAACCGAGAAGGGGGTGACAGTCCTCCATCCACGTGGCCTCTCTCTCTCTCCTCAGGACCCTCAGCCCTGGCCTTTTTCTTTAAGGTCCCCCGACCAATCCCCAGCCTAGGACGCCAACTTCTCCCACCCCTTGGCCCCTCACATCCTCTCCAGGAAGGCAGTGAGGGGCTGTGACATTTTTCCGGAGAAGATTTCAGAGCTGAGGCTTTGGTACCCCCAAACCCCCAATATTTTTGGACTGGCAGACTCAAGGGGCTGGAATCTCATGATTCCATGCCCGAGTCCGCCCATCCCTGACCATGGTTTTGGCTCTCCCACCCCGCCGTTCCCTGCGCTTCATCTCATGAGGATTTCTTTATGAGGCAAATTTATATTTTTTAATATCGGGGGGTGGACCACGCCGCCCTCCATCCGTGCTGCATGAAAAACATTCCACGTGCCCCTTGTCGCGCGTCTCCCATCCTGATCCCAGACCCATTCCTTAGCTATTTATCCCTTTCCTGGTTTCCGAAAGGCAATTATATCTATTATGTATAAGTAAATATATTATATATGGATGTGTGTGTGTGCGTGCGCGTGAGTGTGTGAGCGCTTCTGCAGCCTCGGCCTAGGTCACGTTGGCCCTCAAAGCGAGCCGTTGAATTGGAAACTGCTTCTAGAAACTCTGGCTCAGCCTGTCTCGGGCTGACCCTTTTCTGATCGTCTCGGCCCCTCTGATTGTTCCCGATGGTCTCTCTCCCTCTGTCTTTTCTCCTCCGCCTGTGTCCATCTGACCGTTTTCACTTGTCTCCTTTCTGACTGTCCCTGCCAATGCTCCAGCTGTCGTCTGACTCTGGGTTCGTTGGGGACATGAGATTTTATTTTTTGTGAGTGAGACTGAGGGATCGTAGATTTTTACAATCTGTATCTTTGACAATTCTGGGTGCGAGTGTGAGAGTGTGAGCAGGGCTTGCTCCTGCCAACCACAATTCAATGAATCCCCGACCCCCCTACCCCATGCTGTACTTGTGGTTCTCTTTTTGTATTTTGCATCTGACCCCGGGGGGCTGGGACAGATTGGCAATGGGCCGTCCCCTCTCCCCTTGGTTCTGCACTGTTGCCAATAAAAAGCTCTTAAAAACGC HUMAN SEQUENCE - CODING (SEQ IDNO: 12)ATGTTTCAGGCTTTCCCCGGAGACTACGACTCCGGCTCCCGGTGCAGCTCCTCACCCTCTGCCGAGTCTCAATATCTGTCTTCGGTGGACTCCTTCGGCAGTCCACCCACCGCCGCGGCCTCCCAGGAGTGCGCCGGTCTCGGGGAAATGCCCGGTTCCTTCGTGCCCACGGTCACCGCGATCACAACCAGCCAGGACCTCCAGTGGCTTGTGCAACCCACCCTCATCTCTTCCATGCCCCAGTCCCAGGGGCAGCCACTGGCCTCCCAGCCCCCGGTCGTCGACCCCTACGACATGCCGGGAACCAGCTACTCCACACCAGGCATGAGTGGCTACAGCAGTGGCGGAGCGAGTGGCAGTGGTGGGCCTTCCACCAGCGGAACTACCAGTGGGCCTGGGCCTGCCCGCCCAGCCCGAGCCCGGCCTAGGAGACCCCGAGAGGAGACGCTCACCCCAGAGGAAGAGGAGAAGCGAAGGGTGCGCCGGGAACGAAATAAACTAGCAGCAGCTAAATGCAGGAACCGGCGGAGGGAGCTGACCGACCGACTCCAGGCGGAGACAGATCAGTTGGAGGAAGAAAAAGCAGAGCTGGAGTCGGAGATCGCCGAGCTCCAAAAGGAGAAGGAACGTCTGGAGTTTGTGCTGGTGGCCCACAAACCGGGCTGCAAGATCCCCTACGAAGAGGGGCCCGGGCCGGGCCCGCTGGCGGAGGTGAGAGATTTGCCGGGCTCAGCACCGGCTAAGGAAGATGCCTTCAGCTGGCTGCTGCCGCCCCCGCCACCACCGCCCCTGCCCTTCCAGACCAGCCAAGACGCACCCCCCAACCTGACGGCTTCTCTCTTTACACACAGTGAAGTTCAAGTCCTCGGCGACCCCTTCCCCGTTGTTAACCCTTCGTACACTTCTTCGTTTGTCCTCACCTGCCCGGAGGTCTCCGCGTTCGCCGGCGCCCAACGCACCAGCGGCAGTGACCAGCCTTCCGATCCCCTGAACTCGCCCTCCCTCCTCGCTCGGTGA

[0332] TABLE 3 (mouse gene: Cend1; human gene: CCND1) Mouse genomicsequence (SEQ ID NO: 13) Mouse mRNA sequence (SEQ ID NO: 14) Mousecoding sequence (SEQ ID NO: 15) Human genomic sequence (SEQ ID NO: 16)Human mRNA sequence (SEQ ID NO: 17) Human coding sequence (SEQ ID NO:18) MOUSE SEQUENCE - GENOMIC (SEQ ID NO: 13)CACGGGATCCAAAACCCTCTCCTGACTTCTGCAAGCGCTGCACACACATGGTACATACACATGCACACGCACGTGCGTAAACATGCTGGCTTTCTGATCCTACGGCTTCTAATTTAGCACTAACACTTAGACTTTTTATTCCCTGTTGCTGCCATGACTGACCCCAGACCCTGCCTTTCACGCTTCTCCTTGCTTTTCAGACATGGGACAGTTCTGCGGTCTCTTTTGCAAATTGAGACCTGTGCTCACCTAGCACACATGTGGCCTTGGGTTCCATCCCCAGAACTGAGTGAATGAGGCATGGTGGCTCACCCTGTGATTCCAATATTCAGAATGTGGAGACAGTAGAATGAAGAGTTCCAGTTTCAGGTACACCAAACCTTGTACCAGAAAGAAGAGGGGGAAGAGAAGGAAGAGGAGGGAGAAATCTAGCAAAAGATGGACGAAGCATACAGTGACTTTGAAGATGTGTTAACTTTCCCTTGCTGTAAGGAAATACCTGCGGTAATTAACTTATAAAGAACAGAGGTTATGTGAACTCACAGTTTGGGGATTTTAGTCCAGAACAGGACTCTATTCTACTTCGAGTCTCTAATGCAGATGATGAGAGCGAAATGCTGAGCAAACAGAACTGAACTGCCCTGTACTACATGGCAAATCAGAGGAAGAGTAGTCCCATCGTCCTCTCTGAGGCCACCTTCAGTAACCTAAGGACTGCCAGGCTGTGCTGTTTGTTTGTTCTCTGTCTCTAGGGTGTTTGTTTTCGGGTTTGTTTTGGTTTTGTTGGTGGTAGGTTTTGTTCATTTGCTTGTTTGTTTTTGATATAGAATCATGCTATGCAGCCCAGGCTGTTCTCAAACTTGTAATCCTCCTGTCTTCGCCCCCTGACTACTAGGATCACAGTATGCGCCACCACACCTGGCTCTAGAATCCATCTCTTGGAAGTTCTACCACCTCCCAATAAAGCCACCCTGAGAATGAAGCCTTGGACAACCAGAGAATATTGCTGAGCCAAACTACAGCAAGAAGGCTGACCAGAAGGCTCTGCCAAATTCACAAGCCACTGGCCCATCTGCAATACATGCCATCTGTAAAGGAGTCACTTCTCCCCAGGGTGACAGATTCAATGCAACCTCAATCAAAACCCTAGCTGTGGTGGGTTTGTGTGTGTGTGTGTGTCTGTGTGTGTTTATGTGTGTGTCTCTCTATGCATATCTGTGTGTGTGTTGGGGGTGCTAACCTGTGTCTGTGCATGCATGCACAGTGTCTGAGAAAGAGGGTCCAAGATGCCGGCCACTGTAGGCCATGTTACTGTTCGCATGGGACAGGCCTTAAAGAAGAGCTGCAAAAGAGCCTTGTACCCACCTCCTCCAATGAGACCCACCCCAGTCTGCTTTCTCAGTTAATCTCTTCCTCTCTCAACTTGAAGCCTGTCTGGGAATTTGCTGTTGAGTAGATTATAGGCTTGGCCTCAGCTGGTCCACTAAAAGCAGGAGGTGAGGGCCCAGGCCTGAGGAAGCATTGGGGAGGCAGATCCCAGGCCTAAGTTTGTTGGAGACACATTCTCCAGGACCACAAATAGCTGACATGCTGTTACCAGATTGTCATCCCAGTACCTGCAAAGTGGGAGAACCAGAATCAGGTGTTCAAGGCCAGCCTCTCAAAAAACAAAACTGAAGTAAGTACATCAACTCTACTCTGCCTTTTAAGAGTTAAAAAGGGGCCTGGAGAGATGACTCAGCAGTTAAGAGCACTGGCTGTTCATCCAGAAGAACCTAGGCTCAATTCCCAGCACCCATATGGCAGCTCACAACTGTCCATGACTTCAGTTCCATAATTCCAGGGGATTTGTCATGTTCACACAAACATACATGCAGGCAAAACAGCAATGCACATAAAAAAAAATAAATCATAAAACAAACAACAAAGAGTTAAAAGGACAGGAGAAGAGGAACAAGAGAACGTTCATGTGGCCAGGTTTTCTTTTCCCCAATTTAAAAGTTTCTTCTGAGGTTTACATCTCACACCCATAAAGAGCTCAGAAGTCAACAAAGCGAGGAGGCTTGATTCATCATGAAGTCATTTCAAAATTTCTCTTTCTGAATATAAACCAAAATATTTAATTAATTCCACATACCACAGGAAGTACATTACAGCCTTCAAATTCACTCTGCTTAACAGTAAACTCGTGAACGAATGCACAGAACAGACCCCAGTCACCCACCAGCACTATGCTAAATGTCCTATGCACATTACCTGAATTACTTCTGGCCATGGCCTCGCAGAGGAAATCATCCCACTGCCCAGCAGAGATGAGGGCATCTTTGCCCACAGCCTCTCCAATGCCAGAGAGCACAGCTCTGTACGTTGCCTCCTGTAGTTACAGAAATGTTTTCCAACTTCCTGGCATCCTGAAAAGAAGTGGCTTGCCTTAAAGTGACTTTTCTTTTTCCTTTTCACAAACAGTGCAGGATGGCCTCCTGTGCCAATGACAGGTATGTGCTACCTCATCTAGTTCTGGTAGTACGTGGATTTTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTGTGTGTGTGTGTGTGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAAAGAGAGAGAGTGAGAGAGAGAGTGTTTGTGTACCTGTTCTTTCTTGTGTATGTGTGTACCTGCTCTTTCTTGTGTGCACATATGTGCACCTGTTCTTTCCTCTGTGTGTATGTATCAGCTCTTTCTTGGGGGGGGGTGTATGTCCCCCTGCTTCTGCCTTACAAGGGCTAGTATCTCAAGCAATGAGTTGGTGGAGTTACAGATGCCTGTGTCCAGCTCTCTATGGATTGTTAAGCTGCTAACCTCAGCACACTGGTTTTCTGCCCTGTCAAATGCCTGCGATGACAGCATCCACCTGGTAAGCTGGAAGGTGGGGTCTGCTCCTCCATCCCACCTGACAGGGAATGATTTCCTTAGATAGGCTGCGGCTGGAACTCACCTGATCTAGAAGTACACTGGGGGCACACAGGAGCCATGGAGCCCCTAAGGCCCACCAGCAGCTTCTGTCCTATCCCTTCTGGCAAAGGGGCCATCTGTCAAAGGAGGGGTTGAAAGATGGCCCAGAAGAGGTCTCCTCAAATCTCTGACCCTTACAGGACTCTGATCATAAATGATACAGTCTCAGTAGGCCTATCCTGGCTTCATTTCTTCTGCTGTGATAAAATGTCATTGGGGGAAAAAAAAAAAAGCAGCTTAGGGAGAAAGGGCTTATTCTGGCTCGGAACTCCAGGTTTCCAGTCCATTACTACATGAAAGGCAGTGTGGCAGGAACTTGAAGCACATGGTCACATCATATCCTCCCAGAGCAGTGAGATATGAATCCAGGGGTGGGGACTGGAATGATGGCTCAGGGGTTAAGAGCATCGGCTACTCTTCCAGAGGATGCCGATTAAAACTGTCTGTAACTCCAGTTCCAGGGGATCTGACACCCTCACGCAGACATACTTCAAATAGACATACATGTGGGCAAACACCAATGTACTTAAAATAAAAATAAATAAATTATAATAAATAAATAGGTGCTTAGTTACTTTTCCCACCTTTAATCAGTCCAAGACCCAAGCCTAGGGAATGTGTCACCCACTCCCACACTGGGTCCTCTCACATCAGCTAAGATAGCCAAGACACTACCCACAGCCGTACCCATAGGGCTTCTTGAGACTCTCTAGCAACGTGAATCGAGCTTGTGTCAAGTTGACAATTGAAACTATTATGGTGCTTAACTGCTCCCTGATGAACAGGATGTGGCAGAGACAGGCATCCCATTGGTTAATGTCAGAAGTGTCATCCCTCCGTGGACTGAATTTTTGCCTTTAACTTATATTTATTTGCTTGTTTGTTTATTAGTGTTTGTATCTATGTGCATGTGTGAGTGCGGCTTCCCTCAGAGTCCAGAAGAATGTGTAGAATCCCTCTAGAGCTGGAGTAGGGGGCTGCCGGGTATGGGTGCTGGAAATCAAACCCGGTCCTCTGGAAAAATCAGCAACCACTCTGACCTGTTAAATCATCTACCTAACCTCATCCTTGCTCATGTTTTAAAAATAGTTATAGTGGCCAGGTGGTGGTGGCGCTCGCCTTTAATCCCAGCACTTGGGAGGCATTGGCAGGAGGATTTCTGAGTTCGAGGTCAGCCAAAGTGAGTTCCAAGACAGCCAGCAGGGCTATACAGAGAAACCCTGTCTCAAAGAACCAAAAATAAATGAAATAATTATAGTGGGTTTTTGGACATTCTCTGTATGCTAAGCACCTTCCAGATGGGCTTCCTGACAAGAGATCCGTGGCCTGACCCACACTGATTTGAAATAATGATGAAAATTCAACTTTCAGAAGCAAAGGCTGTAGTTCCTCTCTGGCTTCTACCACAGTCAGTAACCAGTCCAGTTCCTTAGAGAGTCAGTCACCTTAGTACACATTCCAGCGGAGCCAAGACAGTATAGTGCTCCTTATAAACATGGAAGGGCAGTTCCTACCCAGCGAGTCACTGCGGGCTTGGTGCCTCTACTGAAGCGCAGGCTCAACCACCGTTCACCGCGGGGAGCGTCCTCAGGCTCTCGCGAGCCACTGCTGCGCGTCGCGTCCAAGGTTTACGGTAAGCGCGGCGCTCAGGACGACCACGTGGCGGCGAACACCGGCCGGCGGGAATGCGCGGGAATGCGCGGTGCGGCCTCGCGCGCTCCCCAAGCCGTGACCCCGGAGTTCCCGGCGCGCGTTTGTGGGACCGCGGAGGCTAGTGCCATGGGTCCGCCCGCGCGTCCAAGCCACCAAGCACCACAGGGAGCAGGGGCCCCATGGAGGGCTCAGCACGTGAGGCTAGACAACCTTTTCCAAAACCTGGGGCTAGGTTTGCCCTCCCTGTTTGGGCTCCATCACAGATCTGGAACCCGCTTAGTCCCCATTCTAAAGCCCCCACTGATCTGGATTAAGAATGGAGATGCCTGGTTTTGCAGGGAAGCAGGTCAAAGGGCTCTGCGCCCTGACCGCCCTTCGGAGTGCTGAGGGACCAGTGCCAGGGGCTGAAAGACCCCAGTTCCAGCAGCTGCGCCCTGGGATCGCATGAGGGTTCGCTCACCACGATTGAGCCACGTGGTCCTGCCTGGCCACTGGTGGCTCACCTTGGCCCGAGTGCCCCCTCCCCACCATTTAGTCTGGGAAGGGCCGAGGGCCAAAGCCCAAAAGGACCCTAGGGTTCTTCAGAGCACCTGTCATTCGTTCACAGACCTGGACACCGAGCACACATCCCTCCTTCAAATTGCATCTCTACCCTTGGGGGTCCCTGGAGCCAGGCTTCCCCCTCCACAGCTCATTCCACGGCCCGCGTCTATTCGCTCTGCGTCCTGGGATTTAGGGACTGAAACTTATTTCCTAAGGCACGCTTCGGAAGATACGATGCGACGCTCCCAGGTGTCCACAGCCGATGAGCTCAGCATACACACCTTAGCCGAAGGGTGCCTGAAATCCCCTCAGGGTAACCTAGGCGGAGCAGCCGTGTAGCACGTGGGCTGCCACGCGCGCCCCAAAACGCCTTCTGGGTGAGGAGAGGGAAGCCGTAATGCCTCCGGAACCTTGGGGTCCATATTCGGAAGTGTTTTCTCTGGGCGACTTGAAGGCTAAATTAACAATGGCTAGCTGGAGCAGAAACACCCAAGTCCTTTCAAGTTGCCCCCAGGTATGCGGCTGCAGGTGACCCCACCTAGGTGCGTCCGCTCTTCTCCAGGACCGGCTACAGCCAGAGGCTCAGTATTGCCGCCCAGCCCCGCACCCCTAACCCGACCCCCGCCCTTAGTCGCGAGGGTTCCTCAATGAACGCGCTCCCTCCCACTTCTCAATGAGTTCCCACAGCCAGGGATAGTGGCAAACGCAAGACTAAATCTCCGCTCTCTTTGGAACCTTGGCTCCAGTCAGGTCGGGGGTAGGGGTAGGGTTCGAGGAGGCAGGAAATCCGAAACCGGATTAAAGTTACTTTGAGATTTTCTTTCCAAATAACGTGCTTCCCTCTCGGCTGGGCAAGTGGCCTTTTGTCTCCAAAAGGTCACTGACAAATAAGCGCAGAACACTTTAAGCCCAGAGCGGACAGTTCCTGCCACGAGATTTTTTTTAAAGCCAATGTAAAGTTAAAATTCCAAAACAAAGTGGGTGTTTGTGTTTAAGTTACTATTTCGCTGGAAAATAAAAATCCAAGTTCTTTCTCTGAGATTCCTAAAGCAGTTGTCCCGGAAAGAACTCTGAATTGCAGCCCACCTCCTGGGCTCGGGATTCGGACAAGCAGGGTTTCCAGCATGGAGGATGGGCGCTCCCCCCCGCGTCCCAAATTCCTCCGCCTCCCCTACCGGTTCCTGGACGGCTCTACACGCCCGCCAACCGGACTTGCACTTTTGCTCCTCTCCCTGAGCGCAGAGCTCAACGAAGTTCCTCGTGCAGATCTGCCCGGTCCGCCTAGTAACAGCACTGAGTCCGGATTGGCTCATGCAAATTTCAGTTTCCTGGTCTTTCCCGCGGTGGCGGTGGTGCGCGGTGCCTGCGGGTCGCTAGCTCGTGCTGCAGGGTCCGCGACCCCCTTTATGCCCCGCTGCCCTTCGTGGCGCACCCTCGCTAGGCTAGCCTGCTCAGTTCGCAGGCACTCACCCGCGCGTGATAGCGCGCAGCCCTATAAATCATGCTTACTGCCGCCCGGTAGGGATTTTATGAATGAAAAGGCAGCCTGGCCGCCCTCGTGCTTACGCTAAGGCTCCCAGGCTTGGCCCGCCCTGTCCCCAGAGCAAGCGTGCGCACTCTGCCCGGGCCACCCACCACCTTCGGAGCTACAGTGGAATCACTGTCCCGAAGGGTCCGGACTTTAGGGACCCCAATGTCGGGGGAGGGGGAGCGGAAGGCATGAGCTCGGAAGGTGAGGGGTTTCCGTCTTGTGTGCCGCCTGGACGCCGTGCGCTCCTTTACCAGTTTCTTCTGGGACACGAAGGTATTCCGTGGGAAATGTGTGTGAATAGTTCGCCTAGCTTGAAGTCGGGTATTGTGAAAACGTTTCCAAAACTAGGGAACTAAATAATGGACGAAGGTGGTGGAACCGCTTTATTCTAAAAATATTTTATTTGAATCTATAAATTATAAACTTAGGACTCCATTCAGTTAACCACGACCATCTATAGATTCTCTTTAAATATCACCTTATCGGCTCACAAGTTTATCTTGATTCTCACCAGCCGCCCCCCCCCCCCAACTCAAGACTGCAATTCTAAACGTGGAGAAACACCACCACCCTCAACGAAGCCAATCAAGAAGCTTCCGGTGGTCTGGTTCCTGGAAGGGCGACTAATAACTTGCAGCGATTTACTTTTCTTAATTAAAAAATAAATTAGGAAGGAGCCTATCGTGTCTCAACCTTTTCTTCAACGGTTTATTTTTCTTGGGCAAACCGCCTGCAGTGGAGCAGGGGGATACTGGGGGACCCTGGCCAGGATAAACCGGTCACTGTATGAAGACAAATCTCAGATCCCACCCCACCCCCCAGCGAGGAGGAATACATGAAATAATGGCCACCATCTTGAGCTGTTGCTGGAATTTTCGGGGTTTTATTTTATTTTTGACCGAGCGCATGCTAGGCTGGGGATCCTTTAAAGTTCAGATACCCCTCTGGCCCTTTGCAACCACCCCAGTGCGCGAGGATGGAGCCTGCACGAGAGCTTAGGGCTCGTCTGGCATCTTCGGGTGTTACACAGTTCCTGAATTTTACACGTGTTGATGAAATTGAAAGAAGACAGGGACGCTGGGATTTCTAAGCAATGGGTCCGCCTGTGGGTGCCTCGTGGCGTCCTCGGAAACGCACCCATTCTCCCGGTTTAAGAACAGGGTGTCCTTGCACCCCCAGGCTCCCCTTCCATACATTCTTCCTTGGCTTGCGTGTGGCCTGGCCTCCCTCCTAGCTGTCCTCCTCTCCAGAGCCGCCACTACCCCACCTCCACAGGTCTCGGAGGACCCTCTTAGCGAAAGAAGCCCCCCTCCCCCTTCCCCCGCTCTTTCCCAGTTTGGACAGAAGCAGTCCGAGCGATTTGCATATCTACGAAGGCTGAGGGGGAAGGGNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNCTTTATTGCAAAGCAAAAAGTGTTTATTAATAATTGGGGGCAGGGCAGGGAGCGGCAGTAGGGGCGCTGGGACAGGCACGAGGGGCCTCGTGGCGGCCGGGAATCACTAAATAAGACAGTGTGAGGAATATTTGGGGTGGGGGATTCTTTGTTCAAACAGCGGACCTGGGTACCCCGCACACGCTGCCTGGCCCAGAGAAAACGCCAGCCTGCAAGGTCGCGTGGCCCCCTAGTCAATGAGACTGACTGTTGTGCGTGCGGTTCTGGATTTCGAGGAACCTGTCTAGGTCAAACTGGGGGCGGACGGCGACAAAAGCACATTTTCACATGTTCACCAGGAGACTCAGGGCTCCCAAAATATTTTAAAATAATTTTTAAAGTGACGCATAATGCCCTTGTAGAGGCAAACAGCGCCCGCACCCTGCAAAAGGCGGGCCCCCCGGAGTTTGAGTTGCTGGAGCTCACCCCCCAATGTCCACTGAGCTCCTGACCCTCGGCTTGGATCAAGGGTCGTCCGATCGTTATTTTCAGGTCGTTTTTACCCACCTAGTTATTTTTTAAATATTTTTAAATATTTTTTGAAAAGATGACGTCTGGGAAATGCAGCGCGGCGGCCTGGGACGCCACCATTGTGTCTCGCGTGCGCTCGAGCGGCGCCCAGCCCCCGGCGCCCCGCCAGCCCCGCGGTGGGGTTCTCTGGCTTGTGGCTTCCTAATTTCAACAGGGGACCGGGGTCTCCGTGGCCACCATTGCTTCTACCGGCCCCGCCAGCTGCCCAAAGACTTTCCCTTTCACTTTCAGGGTGGGTGGGCACTGGGAACCCTCGGAGCAGGAGCGCATCCCAGGGAGTTGGCCACCGGAATCCCTCTCTGTGCAATCTAGGAAAAGGGAATGGGGTCGTATCGAGCGACGCCCCCCTCCCACCTTGACCGTCAGGGTCCGGATCCCCGCAGGTCTGTGAGCAGCAGAAGTGCGAAGAGGAGGTCTTCCCGCTGGCCATGAACTACCTGGACCGCTTCCTGTCCCTGGAGCCCCTGCCGAAGAGCCGCCTGCAGCTGCTGGGCGCCACCTGCATGTTCGTGGCCTCTAAGATGAAGGAGACCATTCCCTTGACTGCCGAGAAGTTGTGCATCTACACTGACAACTCTATCCGGCCCGAGGAGCTGCTGGTAACCACGTAACCCACCACCGACAATCCCTCTTTATGCTGGGTCGTGGGAGCTGCAAATGGCAGCAGATCCAGCCATCCATGGACAGATCTCCTGCCCCACGAAAGGCACCCGCACCGCACCGCACGACACCGAAATGGCAGTGAGCAGAATGCCAACCCATTCTACCTCTGTGCCCGCCCTCTTTCCGTACTGCACTCCCCACCATGTCTGTGGTGAAACCACTCTGAAATGTGCGCGGTGTGCGCCCCCTAGCGACGTGCAGGCCACGGCGCTGCCGGTGGGAGATTCTTTTTGTCCGCAGTCTGTCCCCTTAGTATTTCTACAGGCACATTTTGTTGTTTACCTGTATGGGGTCCCGGGTTGACCCAACTCTTTAGACCTTCTCCAATCAGCCTGCCTTCCTTTTGACCGTGTTCCTCATTCTCTGCAGCAAATGGAACTGCTTCTGGTGAACAAGCTCAAGTGGAACCTGGCCGCCATGACTCCCCACGATTTCATCGAACACTTCCTCTCCAAAATGCCAGAGGCGGATGAGAACAAGCAGACCATCCGCAAGCATGCACAGACCTTTGTGGCCCTCTGTGCCACAGGTAAGGCTCCACCCCCATTCTTCCCAGGAAGAGCGGGCTCCTTCCCACTCCCCCTCGGGTTAAGGCCTCTTTCCTTGCTATCTATTCTGAGCCCAGCGTGCACATAGTTTGTTGGAGAGATAGATGATACTGGGTGCCACATTCTCTTGGCTAGTATCTTGGAGACCTAACAGAATCACACAGCTTCCCTGTGCCAACCTTTCCACTGCCAGGAAGTGGTACGGCCACAGCATCCTTTCTGAAGAGGTTTTTGCCTCTTTTCCTAGGCTTCCTGCCTTGCCTCTGTTCTTAAGGAGCTCCAGCTATAGAGCACACACACACACACCACCTTCTCCCAGGCTGAGCCACCTCCTAGGGGTTCCTACATGGATGGGACAAATCGTCCAGCCTCAGCCCCACGAGCTACATACAGTACAGCCCCAGAGCACCAACTTAACAGGCCCCACCAGCGCTACTGCACGCCAGTACTTTTTCCCTGAGTCCTGCCTGGGAGGGTTGGCTGGAAACAGAGAAACTAGAACCTCCCTATGACTCCTCCAAGGGACCCTCTCTGGCCCCAGACCCCAGGTAGATTAGCCTGACATAAGTCATGGTAGACAGCCATGCAGGAACCCACACACATACACAACCCTCCTACTTCTGAGTGGTTTCAGTACTACTTCTCACACCTGCTCCTCACCTCTAACTGAGAACCCTACCCAGGAGCCTTAGCAATATTGAGGGGGTGTCGTCTTCTCCCACCTGTTCAGGACCCCCTTCCTCTGTGGCCCTGATCAGACCTCAGTTGCTATAGCTGTTTGGCCTGTGATGTCAGAAGGGCCGGTAGAGTATCTCCCCCCACCCCCAAACCTCCACCTCACCCCCCCTGTCTCAGTGACATCTTCTTATGTCTGACAGCCCCATAGCCAGTGTTTCTAACTCCTCGTGTGAGAATTTGGAAATTCTAGCTTGCCAACTACCTACTGAGAGTGCTGAGCCCGCCCCAAGGGTACCAAACAAGGGGGTGGCAGATGGGAGTAGCAAGGCCATCGGTAGGCTGGAAGGATCTAAGGGGTGGGGGTGGCCCTGCTGGCAGTCAGGGAGGGAGCTGGCTGGGGTTCCTCTCACGACAGCCCAGCCTTTCCAAGCTCCACCCACCCTTTTATGGAGCTGAAAGTGCCTTCAGAGAGGCAGCACAGTTTCCCAGAGATAACTTGGGGATGGAGAGGCACAACCTCCCCCAGCATAGTTCTGGCAGTAGTGTGCCCCTCCCCGCACCCCTAGATGCCACCAGACTAATCAGTAAGCGCTATATCTGGGTACACCTGGACTCAGCTCTTCCAGCTCTCCTTACTCCCTTTGTCTCTGCCCCTGGAATACAGGTGGGGGTAAAGGACAGCTTCGTCACCTGCGGTACGCCAGTGTTCTGTGGTCTGGAGCATTTGTTTCTCTGTAGGAGCAACCAGCTCCTTTGTCACACGGGAACCACTTTGGGAAGAGGCCAGTGTGACATCACCGTGAATGGAAAGATGCTAACATCAAGGCCAGGAGATCTGTCGTCTGTGTGACAGGGGTTCCCCCTATAGGAGATGGGAAGGCATAACTTCCCTTCTGCAAACCGCCCCCCCCCCAACCTGGATTCCTGACTGCAGTTGAACAATGTGCTAGCTAGGGTTGCGGTTGTTAACACAGGTCGCCAGACCGCTGTGTGGATGGATACAGACAGTGGGAAACTGAACTTAATGAAGTATGTAGGTGTCAGACATGCCACTAAGCCAGGGTACACCTATGTCATCAGCAACCAGTGTTAGTAGCTAGGGATCCTTATAGGACATAACAGATCTTCCTACTGCCCGTCGGAGGGAGAAAAACAGGCTCTGGAAGGGGCTGGGGACTCCTGGTCCTGCTGGCTGGAGTCTCACTCCCTGTAAAAGGGCTGTTTGTGATTTGAACTTGACTCCATAGCCACGTTTTCGTTCACTGGACTCACTAGCATGAACTGTCCTTGGTGACACCTGGAGGTATTGCTTGTCTGCTGCATCCCTTTAACAGCCAAAGCTGTATGTTCTCTCAGCGTGGTCCCCAGAGCGCCACCTCGCTACAGCAACTCTCTGCCTTCCTGATCCCATTCCTTCCAGCCTCCTTGATCCCAGGCTCTGGGTGACACACAAGATGATTGATCGGAGCTGACATCTGTTCATTCTTGTGTCCTCCTCTGGCCTGGAAGCCCTGATTCGCAGGCCAACTGACCAGCTGTCCCTCTCACTATTTCTTTGTTGGACGTGACAGCGAAGCAGTTTTCAGACTCATCTTTCGTGGGTTTATGCGGAGAGGCATTCCATCGGTGTGACATACAACTGCAGGATGCTGAGTCCAGTGGACCTGAGAGGTGTGGAGTTGGTGACCCCAGATGAAGTCCTAAAATGACACCCCACTACTTCCCAGTTGGGACATGTACATATGAGAGTCCCTAAGACTCCAGGGCCCCTCATGAGGGACCTTGGCCTGGAGATCTGAGGTGGCTATTCCCAGCTCCCTCTGAGTCTATTCCTACTGGGTTTTCCTGGACTGGGGTCACATGTCTTCCCCAACCTGGGTCAGTAAGCCGGGAAGGCTAACTCCCTTCTGTGGAGTCTAGCCTCGCCTCTGAGGAACCTGGGCCTGTCATCTCTACAGCTTTCTCCTGTGTCTGAGATGTGTCTCTAGTCCTTCCGGTGCTGCCAGGCTGACTCTGGAAGACACAGAGATCCCTGCCTCCCACCTCACCCGCGCAAATACTGGGATGCAGATGTGAAAGCACCACACCTTCATAGATTCCATCCTCTTAGGGCGACATAGCCAACCCCTCCTTGATGTTTGCTGGAACTCCTGGGGATTGAACCCGGTGTGTATGCCAGGCAGCATTTTAAAGTTTCAGCCAAGGCCTTATTCACAGCTAGCATCAAGGCTCTGGCCTGGACACCGTAATCCTCCGATCTGCTGGCGTCTAGAGATGCAGCACTGTGTGCACCTAGTGCCACTTAGGTCTCTCCAAGGGAGCTAGAGTTGATGTGGGCATCCATTGGAAGGGCTTGAAGACCAGCCCCGAGGCTGTGGGTGGGAGCTGAATCATAGGCATGTCTCTGTCCCTCTCGCTGTAGATGTGAAGTTCATTTCCAACCCACCCTCCATGGTAGCTGCTGGGAGCGTGGTGGCTGCGATGCAAGGCCTGAACCTGGGCAGCCCCAACAACTTCCTCTCCTGCTACCGCACAACGCACTTTCTTTCCAGAGTCATCAAGTGTGACCCGGTGAGTAAGTCTCATCAAAGGAGGCTACAGCTGGCAAGGGCCTGGGAACCTTGGTGGGCAGTGCCAAGGCACTCTGTGACTGGGCTGGACCTGAGAGGTGCCAAATCTGGGTCCCCACGAGCCTCTTCCCACAGTCATGGGTCCCAAAGGCATAGAGGGCTGTGGTGTGGTGACAGTGCCCCTGCAATGTGTATGGGTAGTGGCATGTGAAGCCCGGTCTGGCCCAGCCAGCATAGGACCATATCTCCCTCAGTGCAGACGTTGGGGATTGAATCCATAAAGGACTCTGGTATAGACCTACACATTCTAGAACTTTCTTTGTGTGAGAGAGGGGTTTGCATCAGGCAGACTGTGCTACGTCTAACTGTACCTTTCTGCCAAGGAGTACAGCTGATCATGCTTGGGGCTCTGGCCGTGAATGTTTTCTCAAGGGCATCACAAGTTGGCATAGACAGGCAAAAGTCCAGTTCTGGCTTGAACTTCAGTTGGGGGTTCAATGGAGGTCAGAGCCACTGGCATGTGGAAGGCTTCCAGGTGTGACAGCTGTTCTGCCCTGCCTGGCATCAGCCACAGGGACACCCCGTGCCCCATTCCTACATATCTCAATTGTAGAACATGCAGCCCCCTTCCCCTAAGTGTCTGGGGCTCCTGAGAACTGAGAATAGGGTATGTGGGCAGGTTGGAGCCCACAGGCTTCAGAGAGGGAAGGGTGTCTGTGGGTCCATACTAGGCTACTTGGGCCTCACTTTCTCCATCTGTGAAATGGGGCCATTGCCCTTCCATCCTCTAGCCATGGTGTTCATCAAACAAAGGGGGAACAATACACAAGTTTTGAATGTGGGGGCTTCCCAGGTGTTCCCCAGGAATCCTCCTGGCTTCAGGAATATAGACAGTGCCCTAGCTTCAGCCTGCCTAGGCAGGGCTTCAGTTCATGAGTCTTATTCCTGGGCAAATGCTTTCCAGACCCTACCTGTGCTGGAGCTGTCCTCTCTCAGAGGCCACCCAAGGCAAAAAGTTATGAGAGATAGACGCTCCTTGTGGGGAAGTTCAGGGTACAGCCTGGGAGGAGGAACCTAGAGAGTAGCAGTACCTTTCTAGTCTCTGGCAGCTCTCACCGGATTTAGGGGTGGCTTGGGGAGTTTCCTCAAGCCTTGCTCTTAGCAAAGCCTGCCTCGCAGGTCAAGGCCCTGGCCACCGGCCTCTGGCTAAACAAGGACCCCCTCCATCTCCGCCCGCCTCTCCAGGACTGCCTCCGTGCCTGCCAGGAACAGATTGAAGCCCTTCTGGAGTCAAGCCTGCGCCAGGCCCAGCAGAACGTCGACCCCAAGGCCACTGAGGAGGAGGGGGAAGTGGAGGAAGAGGCTGGTCTGGCCTGCACGCCCACCGACGTGCGAGATGTGGACATCTGAGGGCCACCGGGCAGGCGGGAGCCACCAAGTAGTGGCACCCGCAAAGAGGAAGGAGCCAGCCCGGGTGCTCCTGACGACGTCCCCCTTGGGGACATGTTGTTACCAGAAGAGGAAGTTTTGTTCTCTTTGTTGGTTGTTTTTCCTTAATCTTTCTCCTTTCTATCTGATTTAAGCAAAAGAGAAAAAAATATCTGAAAGCTGTCTTAAAGAGACAGAGAGAGAGAGATAGAATCTGCATCACCCTGAGACTACCGAGCCAGGGGGTGCTACAAAAATAGAATTCTGTACCCCAGTAATCAACTAGTTTTCTATTAATGTGCTTGTCTGTTCTAAGAGTAGGATTAACACAGGGGAAGTCTTGAGAAGGAGTTTTGATTCTTTTATATGTTTTAAAAAAAAAAGCTTAAGAAACATTGCTTTAAAAAGGAAGGAAAAAAAATACAGCAAACCATTGTTAAAGTAGAAGAGTTTTTAGGTTGAGAAATGTACTCTGCTTTGCTGAAAAGCCACAGCTTAGGCCCTCAGCCTCACTCCCTGGCTTGCTCAGTGCCTACAGCCCTGTTACCTGATACCTGTGCTTTATCCCAGCCCTGGGCAGACCTCTTAACCTTATAGATGGTCAGTGCGACCTCTAGTGGTCTCATGGCGTGTGGCACAACCCCCCTCCCCAGGGCTCAGCTTAATGTGCCCTCTCCCCCCAACAACCTGCAGGTTCACAGCGCCACCCACACAGCGGTAGGGATGAAATAGTGACATAATATATTCTATTTTTGTAACCTTCCTATTTTGTAGCTCTGTTTAGAGAGATGCTGGTTTTTGCCTGAAGCCCCTGCAGCCTGCCCACATCAGGTTAAACCCACAGCTTTTGTGTGTCGTTTGTTTTGTTGTGTTTTCTTTCTCTATGTTCCAAAACCATTCCATTTCAAACCACTTTTGGTCAGCTAGCTGGAGGCAGTGTTGCTGGTGTGTGTTGGGCCGAGGGGTTCTAATGGAATGCATGGGGATGTCCACACACGCATTCAGATGGCTGTACAACAGGTTGTAGGGCTGGTAGTATGAGGTGCTTGGGAAGTTTTGTTGGGTCAAGAAGAGAGAACTCTGTTCTCGCACCACCGGGATCTGTCCTGCAAAGTTGAAGGGATCCTTTGGTGCCAGCTGGTGTTTGGAAGTAGGAACCATGATGGCATTACCTGGACAAGGAGATTGGGGACAACTCTTAAGTCTCACACAGGAGGCTTTTAAACACTAAAATGTCTAATTTATACTTAAGGCTACAGAAGAGTATTTATGGGAAAGGCTGCCCATGACCAGTGTGACTCAAAGCAATGTGATCTCCCTTGATTCAAACGCACACCTCTGCCCTGCTGGAGAAGGTTTAGGGCCATGTCTGAGAGATTGGTCTTTTATTGGGCAACGGGGGGGGGGGGGGGGTCCTTAAAAAAAAAAACCACAAAGACAGAGATTTGGTCTGCTTGACTTTCCCAACCCAATTGGCCCCATTGGAGAGCCATCCAAACTGAGGAAAATTAGGGGACTCCAAAAGAGTTTGATTCTGGCACATTCTTGCCGCTGCCCCCAAGTTAACAACAGTAGGTAATTTGCACACCTCTGGCTCTGTGCCTTTCTATTAGGACTTTTTGGCAAAAGGTGGAGAGCGGGAGGCTTAAGAGGGGATGTGAGGGAAGAGGTGAAGGTGGCACCACATGGGACAGGCCACGGCTCCTCTCATGCCGCTGCTACCGATGACTCCCAGGATCCCAGGCGTTCAGAACCACATTCTCATTGCTTTGTATCTTTCACGTTGTTTTCGCTGCTATTGGAGGGTCACTTTTGTTTTGTTTTGTTTTGCAATGTCAGACTGCCATGTTCAACTTTTAATTTCCTCATAGAGTGTATTTACAGATGCCCTTTTTTGTACTTTTTTTTTTTAATTGTGATCTATTTTGCCTTAATGTGATTACCGCTGTATTCCAAAAAAAAAAAAAAAAAAAAAAAAACAGGTTCCTGTTCACAATACCTCATGTATCATCTAGCCATGCACGAGCCTGGCAGGCAGGTGGGCGGTCTCCCTCCAGGGATCCTGGGACCCTGATGGCGATCGTCCTGTCATGCTCGGCCCTTCATTTGATCTGGGACATACCATCACAGCAGTCAGGGCACCTGGATTGTTCTGTTATCGATATTGTTACTTGTAGCGGCCTGTTGTGCATCCCACCATGCTGCTGGCCCGGAGGGATTTGCTCTGAGTCTCCGGTGCATCATTTAATCTGTTAGGTTCTAGTGTTCCGTCTTGTTTTGTGTTAATTACAGCATTGTGCTAATGTAAAGACTCTGCCTTTGCGAAGCCAGCTGCAGTGCTGTAGGCCCCCAAGTTCCCTAGCAAGCTGCCAAACCAAAACGCCCACCACCACCTCAGCTGACGCATCCCAGCCAGGCAGGACCCTTCAGGGCCGCTCTGTCCATGGTGATCCGCTCACCTTTTCCCCAAAAGGCCAAAGACTGGTGGTGGCTCCACCGAATCTGCCCTGTGACATGAAAGGCTTTGAGGGACTCTGGCTGGTGGCCAGGTTGGCTTTTTGTATTTCTGGTTGACACACCATGGCGCTTCCCAGCACAGACATGTGACCAGCATGGTCCAGGAAAAAAAAAAGACAAAAAATCTAGAAAATAAAATTGGTAAAATCTCAGCTCACTGTTGTCTGTGTTTTCTGGGAACAGGAGTGGGGTGATGCCACAGCCATGTGGGGTGGCATCTCTGGCCCTGGCACCAACCTGGGATTCCCAAGGGGAAGGGTGTATGCAAGTGACAGCCAAGAGCAAAGTGGGAGCCTCTGGCGTCAGGCAGGCCACCGACACCCACTGATCAGAAGCCGCTCTCGCTCCATCACTGCCAGCTCACCCTCCTGCTTATTTCCAGATGGAAGATCAACAGAACCCGCGTTCACTCCCCCTTGTCTGGCGCAAATGGGTGTTTGCTCTGGCTCAATCACCGTTTCTTAGGTGCTGCCAAGCGCCCAGACAGCCATGCTTAGTGTTAGGGCCAACACCCAACGTGGCCTTTCACATAGTTCTGCAGACCTGACTCCCCTCGCAACACTCCTGTGATGTCTTCCCCGTCGCAGTTACTCATGACTAGTATTGTTTCCAAACCCTGTGGGGACAGGTGGCTTTTAGACATCATCTTCTACAAGGTAGCTTTTGGGTCTCAGCTTGGCTGTTTTGGTGCCTCGTGGGCCCCTGCCCTTCTGGAAAGTCGACGGTCTAGACCACACCTGGTCTGAGTGGTGCCACCCAATGATGAAAGCAGAAAGAGATGGACGGAGGGAAGCCCACAGTGACCTTGCCAGGCGACCTACTCAATGAGAGTATATGGGAACACCAGAGCCAGAGCTGGCTTATGAAGACACAGTACTCATCTTGTACCAAATTGTCTGATCGCAGGATCCAGAAGGTATTTTGTCAGCCCACCTCCATATAAGCATCCGACCCCGGTCCACAGTCACATGGCATCCAGGAGAATGGGCATGGGGCCGTCACCATTCCAGGAAATGGCCAAAGGCCATTGAGCTGGAACAGTGCTTTCCCCCTTGGTTCTTAGAAGCACTGGCGACCGAGCTTATCGTGTCCAGGTACCCTGACATCAGGAAATCCGCTGGGGTCCACCAGCCACGCAGCCAGTGCAGCAGAGTGGTACTAGGAATGCAGACACAAATAGCAAGGGGCTAAGCATCCACTCAAAGGCTGCTCCTGCTGCTCCAGCTCCTGCTTTCCACCACTGCCTATCAAAGGTGCTCATGGAAGGGCGCCCAACTGGAATGGGCAAGCATCACCATCAACTGCACACCGCTCACACATGGTGCCGTCTCTTAACGGTGCAATTGGCTTGTCTCGTCATCCAGTGGTCTGTGATTCCCAGCTGTGGCTGATAGCCAAGCCTCTTTTCTTGGTTTTACCACTGAAACCCCAGATACCACTGCCCACTCCAGGCTCCAACCCTCAAGTTTAACTGGTAACACTGGAGGCTAGATCCTCTGCTGGGTGTAGAGATACTCCTGTTCTAAGGGTGATGGTAAAATAGCTTTTTGAGGGCCCTCAGAGATAAGGACTCAGGGAGCCAGCACACCCAACTGTCTCCTCTCAGAAGCTCAATGGCTGGTTCTCTCTCTGCCTCTACCAGCTCCATCGTCCCCTGCCCTGTGTCCTGGCCAGGCTCTCCTTTTGCAGGCGCCCTCCATCCTGCTGAGCCATCCTACCTCTCTCAGCCAAGCCAAGCTCTTGAACCTGCCTCGCCTCTCTGAGCCTCAGCTCCCTGAACTGGAAAGATTGCCCCTGGCTCCCCATTCTGTGTTGCCCCACTGCCTGGACCTGCTCCAGCCTTCCTGTTTGTCCTACAGGACTCACAGTGAATGTGGCCCCTGTGGAGCATGTGGAGCATGACATTGCACAGGTGACTCTGTCTAGCCTCTCCCCTCCTGACTCCACATCCTACAACCAAGTGTGAGGAAGTTAGCCTGTTGCCCATGGGTCAGCTCAACTGCTGCACTTTGTCCCAGAAAGCACGCCAACTTCACCAACCCTACAGAGGATCTGGGCTCCTGGGGCCCACAAAATGCCAGCAGTGGGAGCTGAGGACTCCAAGGGGTGGGACACAGGCAGAAGAGTAGGACTGTGTGTTCTCCCTGCAGTGCCCCAAAGCCCTGGCCACAACATCCCAGGAGACAGTCAATGCGGGTTGGGCTGTGTGTTTGGTGGCAAGGCTATGCAGGCCACATAAGGCCAGTGCTGGGAGCTGGCACTGCCAAGTGTGCTTGCCAAGCAAACCTGTACTTGAGCTGATAAAGCAGTCTGTTGAGTGTGTGGGGTGGGGTGTATAGGTAACATGAGGCGGGCATGTTGTATACAGGCCCCCACGTCGGCACAGCACAGTGCTGGTGGGATGCACTACCCCTAGTTCTGAGCTGATCTGGCCTCTCTTACTCAGGGATGTCATCCCACGAATGTATTTGATCAAACAGTTGTGCAAGAGGACAAAGCAAGCACACGANNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNACTAAGTAACTGCTAGATCCTTGGACTTCCATTCACAGCTGCTACTGAACCATTGTTGGGAATTGGACTGTAGACTGTAAGTCATCAATAAATTCCTTTACTATATAGAGCCTACCCATAAGTTCTGTGACTCTAGAGAACCCTGACTAATACAACATGCATACACATAAAATTAAAATGTGCCAGGCAGTGGTAGCACATGCCTTTAATCCCAACACTTGGGAGGAAGAGGCACGTGGATTTCTGAGTTTGAGGCCAGCCTGGTCTACAGAGTGAGTTCCAGGACAGCCAGGGCTACACAGAGAAACCCTGTCTCGAAAAACCAAAAAAATAAAAATTAAAAAAATAAGTAGGTAAATTAAATTAAATTAAAATGTTTAAAAAGAAGAAATCTTGGCTGAATATTCTACAGTTTTTTAAGAGTTTGTCAAACATTTTGATGTTACAATGGCCAATGATGACAGTAGCCCCTCACATAAATACATAGTACAGAGGGCAAAAGTGTGCACACCGCCAGTTCAGAAATTGCTGGAAAATTCTGTCCTGACCCTAAGACAAGTTTCACTGAACAATTTTTTTATGAAAATGGTCGGGCTGGAGAGATGGTTAAGAGCACTGACTACTCTTCCGAAGGTCCTGAGTTCAGCTCCCAGCAACCACATGGTGGCTCACAACTATCCATATTCACACCTGACGCCCCCTCCTGGTGTGTCTGAAGATAGCTACGGTGTACTTACATATAATAAATAAATAAATCATCAAAAAAAAGAAAAATGGTCAATTTTTAAAATCAGACATTCTAATATAATACAAACCATAGCTATACTAATTTGACACCTGTTGAGGCCTGAGAGCACAACACATTAAAGACTTGGCTTGCCATAAGGAACCCGTCATGCCTCTGTGAGAGCAGAGAGCTGTGTACAAGATGGATGGACGTTGTACTTCTTACAATCCTGGTCTGGGTTGAGGGGGTTTCATTCGGGTGCTGTGTGTTGGTGCAGATGGAATGACCTCGTCCAGTACAGAGCACAGAACCGAGACTGCATTGAAGTCTTGGGATGCAATATAGGTGAGCGTCTAGAAGCACCCTTAGATCTGATTATGCATTTGATGTACTTCATTTTTAGACAGGACCTCACTATGTAGCTTTGGGTGGCCTGCCTGAGTAGACCAAGCTGGCCTCAAATTCCAGAGGATGCATCTGCCTCTGCCTTCTGGGTGCTTGCAATCAAGGTATGCGTGCCACCAGGCCCAGTAAATTTAATTTTTTCAAATTAATTCTTTTCTCATGTTTAGAAATCTTTTCCTGGTTTTTGTTGTTGTTTGTTTGTTTGTTTGTGACTCCTACATTGGGTTTTTGTGACTCCCATACAGAATTGGGATCCACAGTTTTTAAGAAACTGGGCACTAAATTACCCCTGCCTTATGCAAAGCCCACAAGGACAATCTGGAGAGACCGCTTATGTGAACAGCAGGAGCTGACTCTGTTCAGGGAGCTAAAGGGTAAAACTGTGTATGCTGGACCACTCCATTTCTGGCGGTTCCTGGCAAGCCTTAATGTTACTCATCTGGACCTCCCTCTATTTTCACGCTGTCTTGGCTCTTTACGTTGTAGCTTCTCATGGCCTCCTCCTCAGGGTCCACTACCACCCACCTTAAACAATGCCAGTTCCAGCCTTTCAAGCTGAAATCAAGTGTAAAAGGCCCAGCCATGCTTGAGCAGCCCTTCCCTGCACAAGTTCAACCACAAGCAAACTTCTGAGTGAACTGGGTGGCTAGGACCCTTCCAGAGCAGACTTCCCAGCAGGCCTCTGAGCTTGAGAGCAGGTTCCAAAACTCTTGGTTTCAAGGGTCCGCACCCACTGGCAACAGTAAGGAACCTTCTGGGAGAATGGGCAGCACTTCAAAGTCTTCAATCCTGCAGACACTTGGTCTTTAGGCACTGATGCAACCTCTCCAATAGAGGACTAAAGGACCCACCATCCATGAAGCATGGGGACAGGCACTCCAGCCCTGCAACCCAGGAATGGCCAGCGTCTTATGGAAAGTGCCTCTGGCAAGCTGACCACAGAAAGGCAAGGAGTGACTTCCCTTCTTAGAATATTAACCTGAGGTCACCCTAACTTCTAGGAAATGTGAGCAAAGCCCTATTCACCCCAGATGGGGCTCCAGTGACAGACCAAAGTATACTTCTGCCACAGCCCAATTTGGTGAACCAATGAGTTTCTAAGTGGTTAGTTGGTTATAGGAGTGTGGGAGACACCCCAGCTACAGATAATGATCTTGTGGGAGTTAAAAAAAAAGGGTCCCCACTTCTAGTATACTCCTGAATCCCCTAAGAGCTCTGCTGCTGGGGACAACCAGGTGAAGTAGTGGCTGGAATCCCAGGGTCCTCCCTGCCTTCTCCCTGTCTGTCACCCCCTTACCATGTGGTTATCTCTGTAACTAGTTGCCACAGCAACCTACCCTACATCATCATTAAGATGGTGGTAGAGTGAACTGAACTACAACACAGAGCCACAGGCTGCTGACCTTTGACACAGGTTCCTGGTTGTCAGGGCTCTGGGGTCCCATCCCTCATTTTCTCTGTCAGCCCTGTGACTTCAGTTTCCTGAGATACACAGCAATTTCTAGCTCTGCTCATAAAGCTGGGAGCCACTAAGGTCAGTGGGGCAATCTTTCTAGTCAGCACACTTTGCTCATCTCCAGGTGGAACCTCAAAGTGAACATGGGAGTCTCCCTCCCAGGAAGTCTCCCTGCCACCTCCTCAGCTAACTGACTGCTCCCCTACCTCTGGGCTCCCAGAACCTCGCAGCCATTATCAGAGAGCCCACACGCGGTCTGAAGCATCTCACACCCCTTCAACACTGCTCCTTCTCTATAAATCCATGCTTTCCTAGACCTGCTAGATTCAAGACATGCCATAGGCTCAAATGAGCAAGAAACTAGGCTGGAGCAGCAGGCACAACTCTCACCCCACTATCCTTTGTCCCGCCTGGAATTGGCCCTTTACTGTCACCTCCTGCAGTCTCTCCACCAGCCCACGTTGCTGACTACAGTCTGGTACATGTAGACTTAGTGGTATGGGGAAGTCAGGGCTTAGCAAACAGAACTGTGGCCCCTTCTTCCAGTTTCCTCATCTCACTACCAGGCAGAGGAAGAAAAGGTTTGGGGTAAATAGAAAATAAGGAGGGAGTGAGCCAGAGTTTCTGGGTGTTTGGTCTCAACACAACTATCCTACAAACATCACCATCAGCACCGCTGGGGGATGGAGAGGTGGTTAAGCGTGCTTGATGATGCTCTTGAAGAGGACCCTGCTTCAGTCCTGACCACCATATGACAGCTCACAAGCACATGGAACTCCAGTTNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNAGGCAGGCCAATTTCTGAGTTCAACGCCAGCCTGGTCTACAGATTGAGTTCCAGGACAGCCAGGGCTACACAGAGAAACCCTGTCTCGAAAAACCAAAAAACAAAACAAAACAAAACAAAACTCCTCACTAACACTAGCTTTATACACAACTTCAATCTGTATTTAGCTCCAGGCTACAATTGCTCCTGCAGTCACACTTAGGGATTACATAGTGTCTCTGCAGGCCCAAAAGGCCTTCTGGATCACAGTTTAGACAGACTGCAGGACCATTCTGCCAGGCCCTCTCTCTGTTTAGTTACTTTTCTGTGTTGACAAAAAAAAAAAAAAAAAAAAAAAAAAAAAGGCAATTTGCGGGATGAAGGAGTTTATTCTGTCCAGTTTATAGGTGGCAATCATTATGGTGGGAGGCATGACAGAAGGAGCCTCACGCAGATGCTCATATCGCATCCACGGCCGGTGAACACTGTTGCTCAGCTCACTTTCTCCTTTCTTTTCAGTCCAGGACCCCACTTCATGGGACACACCGCATTCAAGGTGGGTCTTCCCTTCTCAGTTAAGCCTCCCTGAGAAGACCCTCCCAGGCACACCCAGAGGTATCTACGAGGTGATTCTAAATTGTCTCAAGGTGACTATCAAGCAGGCACCAAGCTGAGCAGAAAGACTTGGGGAAACCCAGCCGAGAAACCTCTGCCTCACACCTCCAGCATGTGACAAGTGATTGCTCATAAGGGATGACATCTAAGCTAGAGTCACAGtAAGCCAGAACAGGCTGGCATGAGTGATAGAAAACAGACCGGTAGTCGGCACACATAGCTCACAGGACATGGTCTGACAAGGCAGGGCATTGACCAGCAGCTCAGTGATTATCAAGGACACAGGTTCCACTGGTACCTGACTCTGCCACCTTCAGCGACAGCTTGGCCACAGCTCCCACACTTGTCTATGCCAGTCCAAGTAACACCTTCATGGTACACCATCCAAAAGCAGAGCATTCTTCTGACGACCTATGCCCTCCCCTTTCACAGCAGGTGTGACTCAGTGGTGGGAGGAGGCGGCATGCCCACGTGGCAGAATGGTCCTGTAGTCTGTCTAAACTGTGATCCAGAAGGCCTTTTGGGGTAACCAAAGCATTCTGGGGACTTGATGGGGACTTTGAGAAAGGGTCAAGTGGGCAGAGGTCAAGGCTTGTACAGGAACATGGAAAGTTATCAGGCAAGCGGCTGTGGTGATGCTGATGGGTGGGAGATCTGACACCTGATGTACACAAGGTGAGGGGATAGGAGGTAGAGATGAAGGGAGAAGAGAGGGGAAGAGACAAGAGAGGAACTAGCAACTGATTGATACCTGTAGTGAATGTCACAGGCACAGTAGGCCCATATCTGTGAACCTACATCTTGACATGCACCATCTTGGCACTCAAGCACTGCTGCAGCTGTCAGTAGAAATGATCCCACACAGACTACTGCTTTAAAATACACTATTTATTCTTTTTTCTGAATATAATAGGAAAGTAAAATATGGTGATAACAGCAGCTCAGTTCTCACACCGAAGAGTCCCTGATCCTGGGCACCTGAGAGAGTGGTCCTGAATACCTGAGAGGTAGCCGCCAGGCCCAGGAGGCCAGGTGCATGGTGCCCCAAGCCTCAGACTCAAAACATATTTACAAATCCTTCGGACATACAGCTAGGCTCTATTCTGACTAGATTATAACTGAAGATAACCCATTTATTTTAACCTGCATTCTCCCAGCTGGCTCGTTACCTGTGCTCAGGTACCATGTGTCCATCTCCTCACATCCTCCCTGGTAGATCTCCCACCTGGCTCTATCCCAGAATGCTTTCTCTCTCCCAGATGTTCCGCCTATTTCCTGCCTAAGCCATAGGCCATAGGCTTTTTGCCACAGGTGAGGCATCCATACAACACAAAGATATTCTCTCTACGAAATGCCTGAGAGCACTGTGCCACTCCTGCCAGCTCGTCTTATATCTGCCTGTAAATACCATGCCAGACACACAAGCTGTTGCTAAAGGAAGTACAGTGTCACCAGGCAAGCCCTACACATTCACAGTGGCGGCCACCAATTAGTCCTGCTTTGGTTTCCAATAGTTCCCCTAATGCCACTTTTTGTTTGTTTGGTTTTGAATTCACTTTGTAGACTAGGCTGACCTCAAACTGAGAGATCTGCCTACTATCTCTTGAGCACTGGGATTAAAGGCGTGCACCACCAGCACCCAGCTCCATTCCCACTCCTTAATGTATACAGCTCACCCCACACCTGTTAGGAGCAGCATGAAGGCCCTGCTTCACCTTCCTCCCTTGTCTCGTCACCCTTGTCTTCTCAGCTGGGCATCCAGAGGCAAACCAAGTCCAGTGGAGCCTGAGTCCTGTGCAGATAGCAGGAATCAGGTCCTCCAGTGGTGTTGGCAATGACAGCGCATGTTGGAGGCAGAGGCACCATGTGGTACTTCACGGCATGGACCTGGGGTGGGGGCCAGCTCTGCCACCACGCCCTTAGACTAGATGGGTCTATTTTATCACTTCTAAGCCATAAGGTATCCTCCACCTCTGGGGCTGCCAGAGGGATGGAGTGAAACAAGGAGGCCCAAGCATCGCCAGCAGAGGCTCAGCAGCCAGCAAAGATCCTGTCACGGCTTCCCATGACCCATTTCACATCGGCCTGCCTCTGTGACTCCCACCCTCAGGGTAACCCTACCCAGGGCCACTCACTCTGGCCAGTGACAAGCCGTCTTTTGAGTGTGTTGCCCCTGTGCAGAAGGCAGGGTGGTCAGGTAAGCCACCTAGGCAGAGACTCAGGGAAGAGGCCAAGCTGGTCCTCCCACACAACAATGGATTCCTCTCAGGCTTGCCTTTAATCACTGTGACACTTAATGTGCAGACATCTGCTCTTCTGTGGGTCCTCAAAACGCAAGTCCAGAGCCTCCTGGAGTCACCTTGAAGTCTGGCTGCACGTTGAGCAGTGACCACAGCTGAAAGTACCCAAGAGCCCATGCCTTACACCTCCTGCACTTCTGCTCAGCTTTCCCTATCCCAGCACAAGCCCAAAGGCTATGTCGCCTTAACGTCCCCAACCCACTTTCAGTCATTCTACAAGGGCCAAGGAAACAAGTTCCTCTGGGTCTATATCTGGGCACACATTGCCCAACACAACCATCACATGAACCCTAGGGCCCACGCCAACCTGGCCTTCAAAGCCCCCTCAGGCACACCCCATAGAC MOUSE SEQUENCE - mRNA (SEQ ID NO: 14)GAGGCCTGTCGGCGCAGTAGCAGAGAGCTACAGACTCCGCGCGCTCCGGAGACCGGCAGTACAGCGCGAGGCAGCGCGCGTCAGCAGCCGCCACCGGAGCCCAACCGAGACCACAGCCCTCCCCAGACGGCCGCGCCATGGAACACCAGCTCCTGTGCTGCGAAGTGGAGACCATCCGCCGCGCGTACCCTGACACCAATCTCCTCAACGACCGGGTGCTGCGAGCCATGCTCAAGACGGAGGAGACCTGTGCGCCCTCCGTATCTTACTTCAAGTGCGTGCAGAAGGAGATTGTGCCATCCATGCGGAAAATCGTGGCCACCTGGATGCTGGAGGTCTGTGAGGAGCAGAAGTGCGAAGAGGAGGTCTTCCCGCTGGCCATGAACTACCTGGACCGCTTCCTGTCCCTGGAGCCCCTGAAGAAGAGCCGCCTGCAGCTGCTGGGGGCCACCTGCATGTTCGTGGCCTCTAAGATGAAGGAGACCATTCCCTTGACTGCCGAGAAGTTGTGCATCTACACTGACAACTCTATCCGGCCCGAGGAGCTGCTGCAAATGGAACTGCTTCTGGTGAACAAGCTCAAGTGGAACCTGGCCGCCATGACTCCCCACGATTTCATCGAACACTTCCTCTCCAAAATGCCAGAGGCGGATGAGAACAAGCAGACCATCCGCAAGCATGCACAGACCTTTGTGGCCCTCTGTGCCACAGATGTGAAGTTCATTTCCAACCCACCCTCCATGGTAGCTGCTGGGAGCGTGGTGGCTGCGATGCAAGGCCTGAACCTGGGCAGCCCCAACAACTTCCTCTCCTGCTACCGCACAACGCACTTTCTTTCCAGAGTCATCAAGTGTGACCCGGACTGCCTCCGTGCCTGCCAGGAACAGATTGAAGCCCTTCTGGAGTCAAGCCTGCGCCAGGCCCAGCAGAACGTCGACCCCAAGGCCACTGAGGAGGAGGGGGAAGTGGAGGAAGAGGCTGGTCTGGCCTGCACGCCCACCGACGTGCGAGATGTGGACATCTGAGGGCCACCGGGCAGGCGGGAGCCACCAAGTAGTGGCACCCGCAAAGAGGAAGGAGCCAGCCCGGGTGCTCCTGACGACGTCCCCCTTGGGGACATGTTGTTACCAGAAGAGGAAGTTTTGTTCTCTTTGTTGGTTGTTTTTCCTTAATCTTTCTCCTTTCTATCTGATTTAAGCAAAAGAGAAAAAAATATCTGAAAGCTGTCTTAAAGAGAGAGAGAGAGAGAGATAGAATCTGCATCACCCTGAGAGTAGGGAGCCAGGGGGTGCTACAAAAATAGAATTCTGTACCCCAGTAATCAACTAGTTTTCTATTAATGTGCTTGTCTGTTCTAAGAGTAGGATTAACACAGGGGAAGTCTTGAGAAGGAGTTTTGATTCTTTTATATGTTTTAAAAAAAAAAGCTTAAGAAACATTGCTTTAAAAAGGAAGGAAAAAAAATACAGCAAACCATTGTTAAAGTAGAAGAGTTTTTAGGTTGAGAAATGTACTCTGCTTTGCTCAAAAGCCACAGCTTAGGCCCTCAGCCTCACTCCCTGGCTTGCTCAGTGCCTACAGCCCTGTTACCTCATACCTGTGCTTTATCCCAGGGGTGGGCAGACCTCTTAACCTTATAGATGGTCAGTGCGACCTCTAGTGGTCTCATGGCGTGTGGCACAACCCCCCTCCCCAGGGCTCAGCTTAATGTGCCCTCTCCCCCCAACAACCTGCAGGTTCACAGCGCCAGCCACACAGCGGTAGGGATGAAATAGTGACATAATATATTCTATTTTTGTAACCTTCCTATTTTCTAGCTCTGTTTAGACAGATGCTGGTTTTTCCCTGAAGGCCCTGCAGCCTGCCCACATCAGGTTAAACCCACAGCTTTGTGTGTCGTTTGTTTTGTTGTGTTTTCTTTCTCTATGTTCCAAAACCATTCCATTTCAAAGCACTTTTGGTCAGCTAGCTGGAGGCACTCTTGCTGGTGTCTGTTGGGGGGAGGGGTTCTAATGGAATGGATGGGGATGTCCACACACCCATTCAGATGGCTGTACAACACCTTGTAGGGCTGGTACTATGAGGTCCTTGGGAAGTTTTGTTGGGTCAAGAAGAGACAACTCTCTTCTCGCACCACCCCCATCTGTCCTGCAAAGTTGAAGCCATCCTTTGGTCCCAGCTGGTGTTTGGAAGTACGAACCATCATCGCATTACCTGGACAAGGAGATTGGGGACAACTCTTAAGTCTCACACAGCACGCTTTTAAACACTAAAATGTCTAATTTATACTTAACGCTACAGAAGAGTATTTATGGGAAAGGCTGCCCATGACCAGTGTGACTCAAAGCAATGTCATCTCCCTTGATTCAAACGCACACCTCTGCCCTCCTGGAGAACGTTTAGGGCCATGTCTGAGAGATTGGTCTTTTATTGGGCAACGGGGGGGGGGGGGGGGCGGTCCTTAAAAAAAAAAACCACAAAGACAGAGATTTGCTCTGCTTGACTTTTCCCAACCCAACCCAATTCCCCCCATTGGAGAGCCATCCAAACTGAGGAAAATTAGGGGACTCCAAAAGACTTTGATTCTGGCACATTCTTGCCGCTGCCCCCAAGTTAACAACAGTAGGTAATTTCCACACCTCTGGCTCTGTGCCTTTCTATTAGGACTTTTTGGCAAAAGGTGGAGACCGGGACCCTTAAGAGCGCATGTGAGGGAAGAGGTGAAGGTGCCACCACATGGGACACCCCACCGCTCCTCTCATGGCGCTGCTACCGATGACTCCCAGGATCCCAGGCGTTCAGAACCAGATTCTCATTGCTTTGTATCTTTCACGTTGTTTTCGCTCCTATTGGAGGGTCAGTTTTGTTTTGTTTTGTTTTACAATGTCAGACTGCCATGTTCAAGTTTTAATTTCCTCATAGAGTGTATTTACAGATGCCCTTTTTTGTACTTTTTTTTTTTAATTGTGATCTATTTTGGCTTAATGTGATTACCGCTGTATTCCAAAAAAAAAAAAAAAAAAAAAAAAGAGGTTCCTGTTCACAATACCTCATGTATCATCTAGCCATGCACGAGCCTGGCAGGCAGGTGGGCGGTCTGCCTCCAGGGATCCTGGGACCCTGATGGCGATCGTCCTGTCATGCTGGGCCCTTCATTTGATCTGGGACATAGCATCACAGCGGTCAGGGCACCTGGATTGTTCTGTTATCGATATTGTTACTTGTAGCGGCCTGTTGTGCATGCCACCATGCTGCTGGCCCGGAGGGATTTGCTCTGAGTCTCCGGTGCATCATTTAATCTGTTAGGTTCTAGTGTTCCGTCTTGTTTTGTGTTAATTACAGCATTGTGCTAATGTAAAGACTCTGCCTTTGCGAACGCAGCTGCAGTGCTGTAGGCCCCCAAGTTCCCTAGCAAGCTGCCAAACCAAAACGGGCACCACCAGCTCAGCTGAGGCATCCCAGCCAGGCAGGACCCTTGAGGGCCGCTGTGTCCATGGTGATGGGGTGAGGTTTTGGCCAAAAGGCCATAGACTGGTCGTGGGTCCACGGAATCTGCCCTGTGACATGAAAGGCTTTGAGGACTCTGGCTGGTGGCCAGGTTGGCTTTTTGTATTTCTGGTTGACACACCATGGCGCTTCCCAGCACAGACATGTGACCAGCATGGTCCAGGAAAAAAAAAAGACAAAAAATCTAGAAAATAAAATTGGTAAAATCTCAAAAAAAAAAAAAAAAAAAAMOUSE SEQUENCE - CODING (SEQ ID NO: 15)ATGGAACACCAGCTCCTGTGCTGCGAAGTGGAGACCATCCGCCGCGCGTACCCTGACACCAATCTCCTCAACGACCGGGTGCTGCGAGCCATGCTCAAGACGGAGGAGACCTGTGCGCCCTCCGTATCTTACTTCAAGTGCGTGCAGAAGGAGATTGTGCCATCCATGCGGAAAATCGTGGCCACCTGGATGCTGGAGGTCTGTGAGGAGCAGAAGTGCGAAGAGGAGGTCTTCCCGCTGGCCATGAACTACCTGGACCGCTTCCTGTCCCTGGAGCCCCTGAAGAAGAGCCGCCTGCAGCTGCTGGGGGCCACCTGCATGTTCGTGGCCTCTAAGATGAAGGAGACCATTCCCTTGACTGCCGAGAAGTTGTGCATCTACACTGACAACTCTATCCGGCCCGAGGAGCTGCTGCAAATGGAACTGCTTCTGGTGAACAAGCTCAAGTGGAACCTGGCCGCCATGACTCCCCACGATTTCATCGAACACTTCCTCTCCAAAATGCCAGAGGCGGATGAGAACAAGCAGACCATCCGCAAGCATGCACAGACCTTTGTGGCCCTCTGTGCCACAGATGTGAAGTTCATTTCCAACCCACCCTCCATGGTAGCTGCTGGGAGCGTGGTGGCTGCGATGCAAGGCCTGAACCTGGGCAGCCCCAACAACTTCCTCTCCTGCTACCGCACAACGCACTTTCTTTCCAGAGTCATCAAGTGTGACCCGGACTGCCTCCGTGCCTGCCAGGAACAGATTGAAGCCCTTCTGGAGTCAAGCCTGCGCCAGGCCCAGCAGAACGTCGACCCCAAGGCCACTGAGGAGGAGGGGGAAGTGGAGGAAGAGGCTGGTCTGGCCTGCACGCCCACCGACGTGCGAGATGTGGACATCTGAHUMAN SEQUENCE - GENOMIC (SEQ ID NO: 16)CATGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGGCAGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCGTCTCTACTAAAAATACAAAAAAAAAAAAGAAAAAAAAGAAAGAAAAGAAAAATAGCTGGGCATGGTGGCGCATGCCTCTAATCCCAACTACTTGGGAGGCTGAGGCAGGAGAATCGTTTGAACCCAGGAGGTGGAGTTTGCAGTGAGCTGAGACCGCGCCACTGCACTCCAGCCTGGGAGACAGAGCAAGCCTCTGTCTCAACAAAAAAAAAAAAAAAAAAAAAAAAAAAAGGGGAAAAATCACTCCAATCATCCCAAGTCTCAGCTCCTACTCTTTTGCTATATGTCCTTCAAACCAGCTATGTATTTATTTTGCTGAATTTATGCTGGTTTTATCTTTTGTATCTTGCTTTTTTTCATTTAATGTTTTTCCATCCAGTGAACACACCCTAATTTGCCATTCCCCTCTTCTTGAACATGAGATTGTCTCTAGGGTATCTCTTGCAAATAGGATAATTGTCAATGATGTAACGGGTCTCTATGCAACTTGCAAAAGTGATCAGTCTTGGTGTCCTCCTCATCCTAGTGTTTGGTTCCAAGCAACAGAAACCAATGCTGGCAGATTTCAGCAGAAAAGGAAAATCAGATGCAGAAGATAGGCACGAACAAGGGAGGCAAGACAGCACGAATCACAATGGAAGCATGCTGCAGATCTTCTCTGATGAGAAGCCAGGGCTACCCCTACCCATCCCAACACCAGACCCTCCAGTAAAACTGCAGCGGCCCACACCACCTTGTCACCAGAGCCCACAGCTCTATGATGGGCAGCACAGATACTGCTGCTCATAAACTTGAATGCCTCACCCAGTTCTACACTAGAAAACATTTCCTACCTTTTCTGATTCTTCCCACCACCAGCTCCCAATTCAAAATCTTGATCCAAAAAGATGAAATGTATAAATAATACTATTTATAATGACATCAAAATATCAAGTACTTAAGAAGAAATCTAATAAAAGATGCACAACACCCAACACACACACACACACTCACACACACACACCTGCAATTAAATTAAGGACAATCTAAATAAACAGAGGTCTATATCATGCCCATGAATTGAATGACTCTGTTAGTAAAAGTGTCAATTCCCTCAAAATTGATCTATAGATCCAATACAATCCCAATCAAAATTCCAGCATTGTGTGTGTGCACATGTGTAAGTTGATTCTGAAATGTTTATGGAGCCCCAAGGGCCAGGAGTAGCCAGGGCAACCATAAAAGAGAAGTGGGTTGGAGGATTTAGCCCGCCAGATATCAAGAATTCGTAGCGTATAGCTTCCATGATGCTTCTGGGGTAAGGACTGAAAAAGAGACCAGTGGAACGGGATAGAAAGTCCAGAAACAAGAGATTTGTGTTAAGTGAGCAGATTTTAGCTGCTCTGTTCACAAAAAAAAGTAACTATGTGAGATGACAGGTATGTTACACTAATTCACTATGGTAACCATTTTACTATGTATATGTATCTTATAACATCATGCTGTCAAGTTTATTTCAAAAATAAATTTTACATAAAATCTTAGCAGTGTTATTCATAATAGACAAAAAGTGGGAAAATTCTATTTTTTTAAAGTACAGAAACTTTATTCCTCAAAGGGGAAATAGGTTAATAATAATAAGAAGAAGAATTAAGGCCAGGTGTGGTGGCTCATGCCTATAATCCCAGCACTTTGGGAGGCCAAGGCCAGAGGATTACTTGAGCCCAGGAGTTTGAGACCAGCCTGGGCAACATAGTGAGACCCCATGTTTACAAAAATTAAAAAATTAGCTGGGTGACGTGACAAGTGCCTATAGTCCCAGCTACTTGGGAGGCGAAGGCAGGAGGATTGCTTGAGACCAGGAGGTCAAGGCTACAGTAAGGTATGATCGTGCCACTGCACTCCAGCATGGGCAACAGAGCAAGACCCTGTATCTAGGGGGAAAAAAATGATAAGCCTTGTGAAAGAGAAATGAAAACAGCATCCACACATAAACTTGTACCTCTGTGTTCATCGGCAGCATTGTCCACAGTAACCAAAGGTAGAAACCATCCTAAGGCCCATTGACTGATGAATGGATAAGCAAAATGTGGTCTATCAATACGATTGATAGTATTCAACCATAAAGAGGAATGAACCATGGACACATGCCACATGTGGGCCTTGAAAACGTGATGCTAAGTGGAAAAAGCCAGATGCAAGAGGCTGCATAGCATATGATTCCATCTGTTGGAAATGTCCAGAAAAGGCAGATCCACAGAGAAAGATTAGTGGTTGCCAGGGGCTGGGGAAAAGGGGGAAGAAAAGGGTGAATAACTACAAATGGGTACAGGGTTTCTTTGGCGGATGATGAAAATGTTCTCAGATGGTGATGGTGGCTGTCCAACATAACAAAATCCATCGAACTATATACTCTAAACGAGTGAACTTTACGGTATGTAAGTTATTTTTCAATAAAGTGGTTTCAAAAAAATAAAAAGGTGAACCCTACCATTTCTAGGTGCTTTGGAGTTTACCGTTTTTCTCCTTGCATTCTGGAGTCAGAGTGAGAAGGCATCTCAGCTCTACCACAGCTGAATGATGTGTTGGGCTTCGGTTTCCTCATCTGTAAAATGGGGATAAAGGGCCTCTCCTTGGAGCTGCCATGAAGATTGAATTAGATGCCCTCTGTGAAGATGCAGGGCAGGTGGAGAGCACAGTAAGCGTCTCGGGGGGCCACGCCATCACCGCCAGCAGGGCTCACCAGTATCTTTGCCCAGAGAATAGCCGGGGTCTAGGGAGCAGCCAGGGTCTAGGGAGAAGGGCTGCTTCCCTGTGGAGGCTCCTAACTTTCCCATCTCCTCCCTGTTTCTCCCCTGCCCACCCCTTACTCCTGGAAGTGTGACTCGCTGCCTCCTCCCGTGACTCCCCTACATTGCATCTCCCCAGTTACTGTCGTTATCTCTCATCTCTTCTTTCCAAACAGCCTCTGTCTAGCACCTTGGAGCTCGCATGGGAATTCATGGGTGGGTGGATTCCAAGCTTGGCTTCATCAGATGACAACTAAAACCCACAGGCCTGGGGGGGCAACGGAGCTCCAGCATCTGTCTCCCTTTGGAGAAGCCCAGGTTCACCTTCCCAGCAAGCTGCTCCCGCCCCACGCCCCTGGCCCTCAATAACCTTCAGTGGCTCCCTTCTTGCAGCTATAATTCCCCTCTTGGGATGCTACAAAAGGGATTCCACACATTTTTTTTTCAATAACTCAAAAGGGATGGAGTAAACGATATATGTGCCCAGGACAAGGCAGCTAAGGGAAGCCCTCACCCTTCCTTTGCCTTTCCCTGGAAGTATACCAACCCCCAGCCCGGACGCCCAGCAGAGAACCAATGCTCAGAGCCTGGGGGCCCAAGGAATGCTTTCCAGCCTGGCGGTCCCAGGAGCCCCCTCTCCCTTCCCTATAGCAAGATACTAAGAGCAGACCCTGGCCTGGCACCCCCTGTCGACGCCCTGAGCTCACATCGCCTTCGCACCTTCTTGACAGTCGTGTCTTTTTGTTTCCAGCAGTGACACTCACTGACCCACACCTTTGGCCACCCTCCCTTGTGACTGCCCCCTCCCGCTTGAGCACAATGGCTCCTATTACACAATGGGTGCCACGAACCTGGCCACTCCATCCAGAGACAGCGCAGAGCCCTGGGCTACCGACCCTCTGGGGCCAGCAGAAACCCTCCCTATGGCTCTGCCTCTCATCCTGGCATTGACACTTGTGCCCTTAATTAAAGTGCTTCTTTTTTAAATCAACATTTCTACTCCTTTTGCAGAGTAAGAGAAAGAAGAGTTAGGGGAGAAGAAAGAAGGAAGGATTCATGGGGTTATTTTTTTTTTTTCATGTAAAAGTTTGTTCCGTGATTTAAATCTCATGTCCACAAACAGCTCAGGAGAAGTCAGCATAGACAAGCAACCTGACACATTATAAAGTCATTTGTAAAATCCTCTTTCTGCATATAAACTGAAATGTGTAATTAATTCCACATACTGCGTGTGGCACATGGCCTTCATCCTGCATAAGAACAAATACATGAATGAATAAATCGAGCAGGCCTTGACACTCACCACGCCCTGTGCTAAATGCTTTCTACATATTACCTTAATTACTCCTCACCGTGGCCTTGCGAAGAAAACCATCACAGCCCGTTTTACAGATGGGGACAGAGATTTGTCCAAGGCCACACAACTAGTGGCACATGTAGGTCTGTATGTGACATTCTTGTTCAGTTTCATAAATGTGGCTCCCACCTGCCTGAAATTTTGAGGCAAAAAAAAGTGGTTTGGCTTTGCATGAATTCTTCAAAAAGTAGATTTTTATCTTTACCAGCTTCTAAGCAAGCTGCATTTATTCTGACAGTGTCCATGAAATGGCTACAGACCATCACCGTTGCCAATGTTGTGAACCTGAACAAGGCACCTCGTTTCTCTGTGCCTCGGTTTCCTTACCATTAAACGCATTTCCCTGAGATTAACTGTCTCAAACTATAAGTTGGCTGGAGGAAACACCTCATAGAAGTCAGAAGATGAGGATGCGTGGTCAGTGAAGGCTTTTTCTCCAAACCCTACAGGAGATGGACCTCAAAGCAAATGGCCATGCTTCCCTTAGACTGGGTGAACTGGTGCTGCTCAGGGCTAGAACTGTCTCTAGAAGCATGGGGACCAATGCAGCCCCCTCCACCCTAGGGCACATAACCTGTCTCTCTCCCATAGGATAGCAGAGACAGCTCTCTAAGTCAGGATTCAGCGAGATGGTCCAGGAGGCGCCTAAGGATTCCTCTGACTTATCCAAGCCTGGGGAGGCAACACAACCTACCCTGTGTCTCAGGGGGCCCCAATCATGCCCTGAACCTCATGAGCCCAGGCAGCCATCCTGTTGGTTAAGGTCGGCCTCAGGGTCCAGGGATGCACTAGATTCTTTATCTTAAAGTGACCCTCAAGAAAAAAAAAATAAAATGTAGCTATAGGCAGTTTCTGGACGTTTTCCTATTTGTTAAGCACCTTCTTGCTCCGAGCTTTCCAGCCACAGTCCACTGGACCCCATCGGAAGGCTGCAGCTGCTATTTGGTGCTTTACCACCGCTGAGAAGGTGGAATGGTCACGGCCCGGTTCTGTCACTTTCTTCAGCCGGACAGTCGCCTTATTACCGATTCCAGTAGGGCCGAGCACACTCCTTCCTGCCCGTCTTTACAGATGAACATGCTATCGCTCCAGCAGTACAACCCGCCTTATTACGTAAAAAAGCAGCCCCTATCTACCCCCAGCGAAGGAGTATGTTCGGCACCACAGCTGGACTGGTGCTCGAGTTAAGCGTCCTGGGACGTCCGCATGCGCTCCGGAACCGTAATGCGCGCTTTTTCTAAGCCTTACGGTAAACGCGCACGCAGGGCAACCACGTGGCGGTGGAACCGAGGCCCGGCGGGAATGCCCCCAATGCGCGGCGCGGCCTCGCGCGGTTCCCGAGCCACGGCCCAGGGTCCGGCGGCCCGCGCTCTCGCCTCCTCCCCTCACCTCTCCCAGCCGCACCCCGGCCCTGGCCCTGCCACCCACAACTCGCTGGGCAAGTCGTGCCCCGCGTGAACACACAGAAGGGGCTTGGGGACCGAGCGCGGCCCATCAGTCCCTCAGACCCTGAGGACCCAGAATTCCCTAAGCGGTCCGAATCCGAGTCCTGCCCCCAGCCCTTAAGGCACGGGCTCCAGGGACCCCAGGGGAAGGGCGCGGGGCATTAGGTACGCAACCCGTTTCCCCGCACCTGGAAAAAAACTCCCTTTCCCTCCCCTCCCCTGCTTGTTGAGTGTGCGGATAACCAGAACTCTAACCCGCCCCGTAATAACGACCCCGCTGTCCCTCCACCCACCCCCAAGTGCCAAAGCGAGGGATGGAAGCGCTTTCAAGCGTTCCAAGGGCATTGAGGAGCGAGCTGGAGAGGCGCGGGGATGCGGGGTCCTCCCCGCAGTCTTCCGGAAAGGGCGGGCGACCCCCCGGCAAGTTCCGGAGTGGGGCATGCCGTGGGAGCCCACGAGGGCCTCAGCCCGGATCCTCCGCCGGAAAACCGGCTCCCGCGAGCCGCCGCCGCAGGTTTCCTAGGCCCCGCGAGTCCCGCAGCGAAGCCCTGCGTCTCCGTCCGACGCGGGGGTCTGCTCAGCCTCGGGTCGGCCGCGGCCAGGCCTGACTGCGGGGGAGAGGGCCGAACCTGACCTCCGAGGTCACCCCCAGCCAGCTTTCTCTCCTGTGGTCGGAAGTGGTTTTCTTCTCGATCTGGGCGCCTACTCCCCACCACTTGGTCTGAGAGGGGCTGGGGCCGGAAGGCCAGGGAATCTCTGGTGGATTTGGGGGTTCATATTGCTCAGGGTACCACCCGATGCGTTTTGAGGGGCGGGAGTCGAGGAATTAGAATCGCCTTTAACCCTCAAGACTTCCGCCTTCAGCCTCGGGATCCCAGATGCGTCGTTGGAGCCAGGGCCGCCCCCCTACCTGTTGGGTTTGCGTTTTAACTCCAGCGCACACCTTGCCGGCAGCCCTCGGAGCTAGCGGAGGGGTCTCGTTTCCCCGCAGCCCGCCGGACAGACGACTGGGGCACCCCAGGGGCGGTGGCAGGGTGGTCTGTGTGTGGCTGAAACTAATTGATCTGGACCCGAAACGCACGTCTGCGGTTGGGGCGATGGGGGGGGCGGTGCGGCTGTCCATCTGCCGAGCGTGTGGCTGTCTCGGGTGGGCACTGGCGCCGGAGTTCGCCCCCGCCCACCTCGCAGTTTTGGGGCGCCTGGGATCGGCGCTACGTAAGCGAAGCAGAGCTGCCATAGCACGTGGGCCGCCACGCGCACCCCAAAAGCAAGCAGTGTGGGGGGAAGGGGAGCTCGAGCGCCTTCGGAGCCCAGGGGCCGGCTTTCGGAAGCGTTTTCCCGCGCGACTTAAGGGCTTAACAATGGAAAACTCGCGGAGCCTGAGCCAAGTCCTTTCAAGTCGCCGCCAGGTATGCGGCTGCAGGTGACCCCACCTGGGTGCGCCCGCCCGCCAGCCGCCCTGGTGGAAAAGCGGGTGCGGGAGGTCGCTGGCGAAAGGTCGGGACTGGTCCCTGCACCACCCGCCCCCAACCCAAGCCCCGAGCCCCGCGGCGCGCACCCGCGCTGAGTCCCGGGGTCTGCGTCGCGGCGCGCCGGTTCCTGAATGAACCCGCTCCCTTCCCCCGCCTGAATGAAGGTTCCCACACCCAGGGACGGTGGCGAACACGCGCCTGCAGCGCAATTCGCTTTCTCCTCACCGACCATCCGCCCAGGCCGCGGTCACCGGGGCGGCCCCCAGGGGGCGAGGAAAGCGTGAAGGTGATTTCAGTTAATTTTGGATTTTCTTTCAAACAACGTGGTTACCCTCCCGACTGGGCCACTTGCCCTTTGTCTCCAAATGGTCACCAAGAAATAAGAACAGAGCACTTTAAATGAGCCCAGAATCCGCAGTTCCTGCTTCGTGGTGGGTTTTAAGAAGACAGTGTAAAGTAAAACTGCAACCGAAAAGTTTTTTAAAGTTGCTTTTCTCTTTGGAAAAAATAAAATCAAAATGCTTTCTCTGCGCTTCTTGAAGCAATGACCCTCAAAAGCCCAGAGGTATTGGCCCCCTCGGGGGACCCGGGGGCCGCCAAGCAGGGTTCCCCCAGGTGGGGGCTGGGCAGCTGGCGCTCCCCGCCGGGCCCCAAATTCCAGCGCCGGGCCCGCAAATTCCAGCGCCTCCCCCGCGGGTTCCTGGACGGCTCTTTACGCTCGCTAACCGGGCTTGCAATTTTGCGCTCGTCCCTGAGCCGGGAAATCAACGAAGTTCCTAGTCGAGATCTGCCCGGTCCGCCTAGTAACAGCCCCGCGCCCCCATTGGCTCATGCTAATTCCAGTTTCCTCTGTCTTGCGCCCGGGATGGGGGGGTGAAGCTCCCTCCTGGACCCAGACCCGGTTGTGCCGGAGTGGGCGAGCCTCTTTATGCCCTGCTGCCCCTAGCCGACTTCGGCCCGCTTCGCGCCTCGGGCTGGGCCAGCCCGCACGCGGGGCTCGGGGCCCCTCGCCCCACGGGATGGGAGAGGCCGGGTGATAGCTCCGGGCCCCATAAATCATCCAGGCGGCCGCCGGGTCGGGATTTTATGAATCAAAAAGCAGCTGGGCCGCCCTTGTGCGCGGGCTGATGCTCTGAGGCTTGGCTATCCGGGGGCCAACGCGATTGTGGGTGCTCGGGGAGTGGGGGGGGGCACCACCGTAGGTGCTCCCTGCTGGGGCAACCCATCGCTCCCCATGCCCAATCCGGGGGTAATTACCCCCCCAGGACCCGGAATATTAGTAATCCTAATTCCCGGCGGGGGAGCGCCCGCCGCAGGAATTCACCCTGAAAGGTGGGGGTGGGGGGGGTCGCATCTTGCTGTGAGCACCCTGGCGAAGGGGAGAGGGCTTTTTCTATCAGTTTTCTTTGAGCTTTTACTGTTAAGAGGGTACGGTGGTTTGATGACACTGAACTATATTCAAAAGGAAGTAAATGAACAGTTTTCTTAATTTGGGGCAGGTACTGTAAAAATAAAAACAAAAGTTAAGACAGTAAAATGTCCTTTTATTTTTTAATGCACCAAAGAGACAGAACCTGTAATTTTAAAAACTCTGTATTTTAATTTACATCTGCTTAAGTTTGCGATAATATTGGGCACCCTCTCATGTAACCACGAACACCTATCGATTTTGCTAAAAATCAGATCAGTACACTCGTTTGTTTAATTGATAATTGTTCTGAATTATGCCCGCTCCTGCCAGCCCCCTCACGCTCACGAATTCAGTCCCAGGGCAAATTCTAAAGGTCAACGGACGTCTACACCCCCAACAAAACCAATTAGGAACCTTCGGTGGTCTTCTCCCACGCAGAGGGGACTAATATTTCCAGCAATTTAATTTCTTTTTTAATTAAAAAAAATGAGTCAGAATGGACATCACTGTTTCTCAGCTTTCCATTCAGAGGTGTGTTTCTCCCGGTTAAATTCCCGGCACGGGAAGCGAGGGGGTGCAGTTGGGGACCCCCGCAAGCACCCACTGGTCAAGGTAGGAAGCCAGCCCGAAGAGTCTCCAGGCTAGAACCACAAGATGAACGAAATGCTGGCCACCATCTTGGGCTGCTGCTGGAATTTTCGGGCATTTATTTTATTTTATTTTTTGAGCGAGCGCATGCTAAGCTGAAATCCCTTTAACTTTTACGCTTACCCCCTTGGGCATTTGCAACGACGCCCCTGTGCGCCGGAATGAAACTTCCACAGGGGTTGTGTCCCCGGTCCTCCCCGTCCTTGCATGCTAAATTAGTTCTTGCAATTTACACGTGTTAATGAAAATGAAAGAACATCCAGTCGCTGAGATTCTTTGGCCCTCTGTCCGCCCGTGGGTGCCCTCGTGGCGTTCTTCCAAATGCGCCCATTCTGCCGGCTTGGATATGGGGTGTCGCCGCGCCCCAGTCACCCCTTCTCCTGCTCTCCCCAGGCTCCGTGTCCCCTGCCGGCCTTCCTAGTTGTCCCCTACTGCAGAGCCACCTCCACCTCACCCCCTAAATCCCGGGGGACCCACTCGAGGCGGACGCGGCCCCCTGCACCCCTCTTCCCTCCCCCGGACAAACGCTGCAGCGGGGCGATTTGCATTTCTATCAAAACCGGACTACAGGGGCAACTCCGCCCCAGCGCAGGCGCGGCGCCTCAGGGATGGCTTTTGGGCTCTGCCCCTCGCTCCTCCCGGCGTTTGCCGCCCGCGCCCCCTCCCCCTGCGCCCGCCCCCGCCCCCCTCCCGCTCCCATTCTCTGCCGCGCTTTGATCTTTGCTTAACAACACTAACGTCACACCGACTACACGGGAGTTTTGTTGAAGTTGCAAAGTCCTGCACCCTCCAGACCCCTGTCGGCGCAGTAGCAGCGAGCAGCAGAGTCCGCACGCTCCGGCGAGGGGCAGAAGAGCGCGAGGGAGCGCGGGGCAGCAGAAGCGAGAGCCGAGCGCGGACCCAGCCAGGACCCACACCCCTCCCCAGCTGCCCAGGAACAGCCCCAGCCATGGAACACCAGCTCCTGTGCTGCGAAGTGCAAACCATCCGCCGCGCGTACCCCGATGCCAACCTCCTCAACCACCGCGTGCTGCCGGCCATGCTGAAGGCGGAGGAGACCTGCGCGCCCTCGGTGTCCTACTTCAAATGTGTCCAGAAGGAGGTCCTCCCGTCCATGCCGAAGATCGTCGCCACCTGCATGCTGGAGGTGCGGGGCTTCGGGCGGCTCTCTTAAGACTTCCCTGCAACTTGTTGCCCAGACCCACGTTTCTTTGCTACTCACCCCCCTCCCTTCTCTCCCCCTAGAACTTTGAAGTTTGCCGTGGTGTTTCTAGGGATCCGTATTTTCAAATAAAAAATTGCGGGTATTTTCTGAAGGAGGAAGGGGTGGGGGTGGGGGTGCTAGAAGTAGCGTTTCGTGGGACGGGAGAAGGGGGTCCGGCAGGCGTGCCTTCGGGAGAAGCCAGTGCCAGGGGCACCCCAATCCGCCCGAGGGTGCGGGCTGGCAGGCTGGCTCCGCTTTGTGTCCCCCGCCTGCGCCCCAGCCCGGCTGCGCCTCAGCGGCCCGGAGCCGCCAACTCCGGGGGGAGGGGGCATAGATTTGATTTTTAAATTAATATCCATGGACACGTATGCAAGGGCCGCTCGTGCCAGTATTATGCGCCATCTTTGCTCTTTTATTGCAAAGCAAAAGTGTTTATTAATAATTGGGGGCAGGGTGGGGGCGGGGAGCCGCCCCCCGGCCCTGGGGCCGCAGCTAAGGGCCGCGCGGCTGCCGGGAGCCCGCGGGAGGGCCGCAGGGACGCGGCATGGGTAGTTTTGGGGGGACCCCGCTAGGGAAGGGGGGGCCTTTGTTCAAGCACCGAGTCCCGGGGCGCCCCGAACGGGCAGCCTGCGCCGGAGAGCACCCCGAGCTGCAAGGTCGCGTGGCCCCCAAGACGCCAGGGCTTGATCCCCGTCTGCAGGCATATCGGCTTGCAGGACCTTCTCCGAGCGAGCCGGGGGCCTGGGAGCACATTTTCAGACCTTCCGTGGGCGCCTGAGCCGCCCGCAAGTATTTTAAAATAATTTTTGAAAGTGCGGCGTGGTGCCCTTGCGACAGGGAAACGCCGCCCGCGCCCAGGGGGAAGGGGCGCCCCCGGAGTTTGAATTCCTGGGGCTCCCCCCGGAGCCTGTAACGAACTCCCAACCCCCGGCCTGGGTAAAGGGTCGCCCGAGGGTCATTTTCAGGGTTTTTTTATGCACTTAGTTATTTTTTTAATATTTTTAAATATTTTTTGAAAAGATGACGTCTGGGCAAATGCGGCGCCGCGGCCTGGGACGCCACCTTTGTGTCTCGCAGGCGCGGCGCCCAACCCCGCGGCCCGTTCCGCGGCCCCGCACCCCAGTTGGTGTCGACCCCCAGTCAGACGGACCACGGAGCTCCAGGGCGGGCCAGCGTCCCGGGGGCCGGCAGCCCGCGCCGCCGCGCACGCCGCCCAGCTGTGCCCGCTCCCGCCCCCACCGTGCCACCCTCGCGGGGACTTTCCCTTTCAGTTTCGGGGAGGGTGGGTACTGGGGACGCGCGGGGGACGGGGCGCATCACGCGAAGCTCCTGCCGCCCCCAGCCCCGACCCCTCGGCGCCCTCCAGACCTGGCGGCCCTGCCAAGCGCGATGGGGGGTGCGGGGGCGTGCGGGGGGGCGGCGCGACCTGCCGGCGGCGGTCACGGGCCCCGTGCCTCCGTAGGTCTGCGAGGAACAGAAGTGCGACGACGAGGTCTTCCCGCTGGCCATGAACTACCTGGACCGCTTCCTGTCGCTGGAGCCCGTGAAAAACAGCCGCCTGCAGCTGCTGGGGGCCACTTGCATGTTCGTGGCCTCTAAGATGAAGGAGACCATCCCCCTGACGGCCGAGAAGCTGTGCATCTACACCGACAACTCCATCCGGCCCCAGCAGCTGCTGGTAACCACTGGACCCCGCCGCCCCCCGCCCCCCGCCAGCCGCACGCAGGACCACGGGGCCGGGGAAGGTGCAGGCGGTGGCGGCCGGCCCCCCTCTGACATATCTGCTCCTCCGAGGGAGGGCGGCCCCGCCGCCGGGCGTCCCTGTCCCGGGAGCGGCCGGGATCCTAGCCGCCCTCGTCCCGCCGCCCTGTGTGCGCTTGCCTGCGACTCCCACCCCGTTCGCGCCCCGCGGTGTGGCCGAAAAGTGGGCGGCGCGCGCCCTCCAGCGGCTGCACGAGGAGCGCCGCGCTCGGCGCTGAGCCTCCAGTTCCAGGTGGTGCGAGGTCTTTTTGTTTCCACTTGCAGAGTCTTTTCACGCGCCGGGCGCCTTTTCTGTTTTGATCTGGGATTGCGTGTTGCCCCAGCTCCCTTGAGTCCCCAGCATTCGCCAGCCCTCCCCTCCAACATCCAGGACCGCACGAGACCCAGGGGCCAGTGCTCTGAGCCGGAGGTGCGGCGTGGCCCGGCCCCCGTGCTGCCCGCTTCCCCGCGCCCCCGGGCTGGCCCGCACCTCCCCTGATGGCCGCTCACCCTGTGTTCGCAGCAAATGGAGCTGCTCCTGGTGAACAAGCTCAAGTGGAACCTGGCCGCAATGACCCCGCACGATTTCATTGAACACTTCCTCTCCAAAATGCCAGAGGCGGACGAGAACAAACAGATCATCCGCAAACACGCGCAGACCTTCGTTGCCCTCTGTGCCACAGCTAGGGCAGGCCCGGCAGCCCCCGGCCTCCCCTTGAGAGCCGGCTCCTTACCTGACCCTGGCCGGCTTCTTGCTCTCCACCTGGGTGCTGTCTGGGAAGATCTCCCCACACCCCCTCCTGCGCTGGAGAGCGCTCTTCCACCTCTGGTGAGCAGAGGCCCTGGATTGTTTGTCGCGCTGGATGCAGGGAGATTTGCTCCCTCACGGCCACCATGCACTACCTTGGGCATTGGTGTGGACGGCTCAGCCTGCCTGTGTCCCGTTACTCTCCCCTCGTCCTTCAGGCCAGGCAGCCTGTGGCCACTCCATGCTGAAAGCGCTTTACCTTGGCCACAGGGCCGCCTCCTTTCTCCACCCACCTCCAGCCCTTCTTGTGTCCTTAACGAGCCTGAGCTGCAGAGGCCCCCTCCTGGCCTCTCCCAGGCTCGCCCACCTGCCAGAGCCGCCTCCAGGGGCGGGGAGAGCTGTCGGCCTGCCTGCACCACGTGCTCTGGGCAGCCGACTGCAGGGGTGTCCAGCAGAGGAGCTCGGCTGCCTGAGGCCCTGCCACGGCTGCCGCCAGCCAGCCGGGCTCAGCTGAGCCCTGAGGGGGCGCTTCACAGCACTCTCAGCTTGGGCCGCCACCGTGGGCAGCAGAAGCACCCAGTCCTCACTTCCCCTGGCATGGCCCCACAGGCCCCTCCCTGACATGGCCTTGGCCCCAGAACCCAGTGGGGACACACTCGCACATACACAGGGTGCCGCCTCCTGCTGTCCCCAGCCCTGCCTCTGACCCCCCTGTGACCGCCTCCTTCCCTGGCCCAGGAGGCCTGGTTACCTTCATGGGGGAGCATCGCCCCATCCCACCCAGCTCTGCTGTGGCCCACCTTTGCTCAAGCCTCACTTCTCACATCTGTTTGGGGGCTCACTCTGGGTGACCTAGGCCACAAGGCCCACGCGGCATCAAAGAGGCAGTAGCATCTTCTCCCCTCCCCAGAGGGCAGAGCCCCCCAAGCCTACTTCAGAGCTCCCTTCTCACACCGGTAGCCCGCAGCCGGTATTCCAGAATGAATTCTGGTTTAGGCGTGAGGCCTCCCCCACCTCCTCCACCTGCTTGGGGCATGAACCCCTCCCCCACGTTTCCAAGCGAGTCCCCAAGGTGGGCAGATGAAGATGCCAAGGATCTCGACCAGTCTGGATGGGTCTGGGGTGGGGGGGCATGCGGCAGACAGGGAGCCATTCTCTGGCTGGTGCTCCTCAGAGGAGAGAGGCCTCCGGAGACTCCAGACAGCCTTTTATGGAGCTGAAAGTGGCTTCAGAGAAATGCAAAGTTTCCTGGAGAGAACGTGGGGCGTGGTTCTTGCACAGCCTCCCTACAGGGTGGCTCCAGCAGTGGAGCTCCCCTCCCACGACCCCTGGGTGCTAGTGGGAGGCAGTGGGCAGGTGCAGATTCTCGTCCTTCCCACTACTGCACACCCTTTGTCTGCGAAGGCGCCCCCAGCGGTGGGTGAAGGAGGAGGGACACTTGGGGACCCAGCTGTGCACGTGCTCTCAGTGACTGTGGAGTCCACTCCACGGTGGGTCCCGAGGGAGGGGCAGGAGACCAGGGGACCCACCCCTGCAAAGTGCTCCGGGTCCTGACCCGTGGCCACCCCATGGAACGTAACTGAGCAGCCACTGCCTTGTTCCTGCTGGACATCTGTGGAGACAAGAGTGACTTACGGCTGCTTAAAGTCAGAAACAGGTTGAAGGAGGTGGAGGCGTGGGAAAGAGTCTAGGAAGGTGTTTTTGCCCTCCACGTGCCAAAGGTTACATTTAAAGGTGATGCTGGGTGTTCTCCCTGCACTAGCCATTCCTGGCCCCAGGTCCCCAGCAGGTGTGCACATGCTCCATACACTCACGCATGGGGGTTTCAGGGCAGGTGCGCCCTTGGCTCCGTCCGAGGCCAGGTGAGGAACGTCCAGTGCCAAGGAGCTTCCGGGACAGCTGTCACTTCCCTTTACAACCAGGCAGCGGATAGGGTCAAATCCTGGAGCTTTGGTGTCTAATTCTGGGTGGCTCCTAATCTAAGCACAGACAGCACCACACACTGGCGTGGGGGCACGAGCTTCTGAAACAACGTGGCCCCAGTGACTCCACGCTGTGTGTGCCCCTGGAGACGGGGGGCTGCACAAGGTGCGGAGCCAGCTAGAACCTGTCGCTCCCTGCAGAAGCGGTTTCTGTGTGCGGTTCTGATTTGCCTCAATGAGAAGGTTTTCATTCATCGCTCCCGGCTCTCAGACTGCGTGGAACTGCTCCCATTTAAAGGGGAAAAGAGGTGCCTCGGCTCGTTAAGGATTTCTTTTTCTAAGTTGTTACGGCGCCCACCAGCCGGCTTTGTCTCCCCTTCAGGGTGGCTGCCTTTCTTCCCCGCCCCTCGCCCCCGGCCCTCTCTTTAACAAGGCCGAAGTTGTTTATTCTCTCGGGATGAAGTCTCGCATGGGCCGCCACACCCCTGGCGGCCCGTGGGGGCCCCTCTCCCTTTGTGCCTGGGTCGGCTCCCATTCAGCTCCCCCGACCCCCCTTGTTCCCGGGCGCTCACTCGCGCGAGATGAGGCGATGGGGCCCACAAAGATGCCACACTCATCCCTGCCGACCTCCGGCTCCCAGCCCAGGGCCCCTCGTTCCTGTGCAGAATTCCTCGTGGGTGTGACAAAACCCTGCCCCCAGGCTCCGCTGGCGTGGGGGCCAGGCCAAGAGCCACATCCCACACTGGCCCACCTGTCCACCCTAGCCGCATGACTCCCCTGAGGAGGGGAGGCCGGCATTCCCCGCCACAAACCAGGACGTAATTGGTGGCAGGGCTCTCTGTGGAAAGAGCCAGTCTGCTGTTTGTCTAGGAGGTCAGTCACAGAGGCCCCGAGACGCCCACTACTGCAGCCTGGCAGGCGGATGAGCCCAGTATCTGGCAGTGACCAGAGGGAGTTTTGTGCAGACCACAAAGGCTGATGCCCTGCCCTAGATTGCTCTCCCTCTTGCAAGTGGGCCCAGATCTGCGGGACAGTCCCCAGCAAGCCCCAGGTCAGGGCACTGGTGCCCTCTTGGGAAAGCTCCTCCCTCCTGGGGCCCGGCTCCCGGCCCAGTCCTCCAGGGGTGTCCCATGGTGACTGGTGCTAGCAACCCCACACCTCTTCCCTTACTTGGGAAGTCACTGGAATTGTTCGGCTACATCAGACCGCCCACAAAACTGTTTTTCTCATCGGCCAGAAATAGGACAGTTGTGAGTACAGGCCCCGGGTGGAGTTGGCGTGTACTTGGTCTGTCCTCTGAACCTCACTGTCACAGTCATGGTCCCATGGTAAGGGGCATGGGTTGCTGGAAGAGCTCTTCCTTCCCGAGTGAGCCAAGCCGGGCTCTCCTGGCGCCAGGCCCTGAGCCGCAGCCACACCACAGCCCCCCTGAAGGCTGCCGGCCAGGGCTTACCCCTCAAGCCACACGGAATGCCTTCATCAGTACCCTCCAGCCCCGTGGCCTGGCCCGGGTCGACCCCTAGGCTTCAGCCATGCGATGTCCCTTCAGAATATGACTTCTCTCCAATCCCTGCTGCTGGGGGGTGGCAGGTACTTGGGGTCAGGGTTAGGCTCATAGAAGCGACATCTCTACGTCCTCATATTTGCGTCATCTAATTTTGTTTTTGTGAATACGTGATAACATTCACAAGGCTCAAGATCCTAAAAGGATGAGAAGGCAGTGATGTCCCCATCACCTGTCCTCTGTCTTCCCGTGGCTTTCTCTTTCCTTGGTTATGTTTGAGTCAACAGTGGGGCTGACGTTCCACGACGGTCCGTCCGCCAGGCTCTTGCTCTCCGAGTGCCCAGGGATGCCTGGAGGCTCAGGAGCGCCTGGATGTGGAGCCTCACATACCAAGTGCTTCCCTTCAGCCCGCCCCGCTTGCTCAGAGCCACCACACAGGGATGCCCGCATCACGGGGCCCCTCACACGGTCCCCTGCTCACAGCCTCCTTCCCTCTCTCCTTCTGCCTCAGATGTGAAGTTCATTTCCAATCCCCCCTCCATGGTGGCAGCGGGGAGCGTGGTGGCCGCACTGCAAGGCCTGAACCTGAGGAGCCCCAACAACTTCCTGTCCTACTACCGCCTCACACGCTTCCTCTCCAGAGTGATCAAGTGTGACCCAGTAAGTGAGGGTGATGTCCCAGGCAGCCTTGCCGGGGCTTACAGGGGGAGACACCTAGTGCCACGGAAATGCCCAGGCTGGTGCCAAGGCCCCCAAGGGTGACAAGGTTGGGGCTGGGGCTGGGCCCCTCGGACCCCACGCCACAGACTGACAGGGCACCGGCTTCTTCCACTGCTCCTAGAACTTACTGACTGGCTGGGAGGTCCTCACACCCTTCTCACGTCCCCTGGGGCTTCCAGGAGCCGTAGACTTTCTGGGCGAAGCGTCCGGGACGGAGGCCCCAGGCGGCCCCAGCCAATGGTCTGTGTGGTGATCGTGTGTGGGGTTAGGCCCAGGCGAGCTTTGTTTGGGCCACAATGTGCGTGCCCAATAAATAGATGCTTGAAAAGGGCTCCTGTGAGGTCCGAGACACCGGACAACGGGCGGATAGAGACAGCCTTGTTGTTTACGGCCTCTTTGAGAGCCTGCTCCTGTTAAACCCTGGGATGACTGTGTCTTTCTTCTTAAAAATGCCATTGTTTTATTCCCGAGTCTTTTCTTAAAGAAAGAATTAAAATGACAATCAAAAGGGTTTGTGGCATTTACCAAATTAGACCAGAGACGTGGCCGGGTCAGCCGCCGGCCCCCCGGTGTGTGAGGCAGTGACCGCCTGACCCCAGCTTGGGGCTGGGTGGGCCTGCAAGACCCGTTTTGGCTCTGGCCTGGGCCCCCTCTTGGTCGTCTGCCCTCGAGCCTCCCGGGGACTCCGCACGGGTCTCACCAGATGCTATCTAGGGTCCACCTGCCTGTCCCCTGCCTAGTGGTCCCTCTGTCCCGGCGACACTGGGAGTAGCGGCTGCCCAGCCCATGTGTGTCTCGGAAGACGAAGAAGCTTTTTTGCCGTGCGACACCGAAGTTGGCAGGGGCCTCCCTTCTGTGTTCTCGGCCATGGCCTCCCTTGCACCCTGCCCCGTGTTATCCTTTGGGGGTGGTGAGGTGTCCTCACCCGCTGTAGGGTGGAGGCCAGCAGCCCGCAGCTCTCTCAGGAAAATGGCTCAGAAACACCATCGAGGCCTCCAGAAGCCCAGCAAAGAGAAAGCCCCTCCATCAAAATGAAACTCGCGTCTCCACTTTTCATTTCGAACTCCACGCCCTGAGTGAAAACCGCTTCCCCGCCAGGGGTGACTGCCCTGGGATGTTGCTGTCTTCGGGCAGTTGTGGGAAGTTGGGCGCTGGCCCTTATTTGAGTAGAGACCATCTTAACTAGATTGGAGGCACACGTCTCACAGCTGACACACACACGGGGTGAAGTTACCCGAGGCGGAGTCCACTCTGCCTGATCAGCTAGTGACCAACGTAGCTGAGCCCAGACTCAGAAAAACCGTCCACAGCAGAGCCCCCTGCATTTTCTAGGGCGTGTTCTAGAATTTTCTTTGGTGGGTGGAATGTCCATCTGTGCAAATCGGGTGCGCAGTGCCACACACCAGTGACTTTTCGCGGAGGAGCGTGCTGCCTTTTTGGAGCTTCTGGCTGTGGGAGAACAGCTTTGTCCACCCGGGTAGCCTTCCAGGCAGCTGTGGGGCCAGAGGAATGAAGGAAGGTCCTGGACTCTACCTCCATGTGTGACCCTGGAGTGGGTCATGGGCGAGGGACGGGCCGCAGGTGAAGAATCCCTGGATGGAGCTGCCAGGCCCCTGGGGCTGAGAATTGAAGCTGGCTGGTGTTTTAGGTTGAACGTCAGGAGTCTTGTATCTCACCCCAGGCCTCTGGCCTCAGTTTCCCCATCTGTACAGTGGGACTGTTTGTGCAGCCACCCCGGCCAGCTTCATTTGCCATGATCAGAATTTATCTGAGGGGCGGGAGAGGAAAGCCCTCCCTATAAAGGTACAGGCGCTAAAATCTCATGACCTCAGTGGTCCACCTAAAAGTCGTTCTGGCCTGGGTCATCGCCTGTCGTGCTATGCCTTTGTCCAGCCCCTTCTGGTTGGCAGTTAAGTGGCACCTGTGCGGCACGTGGTGGCGCTGTGGCCCAGCCCTGCTCCTTGTCGAAGGTCTGTTTCCTGGGCTGCCTAGAGACTTGGCTTGAAGCCCTAGCGTGGCTTCCTGGCAGTTGGGACACACACAGCCCCAACACATGGAGCCGGTTCTCCATCCAGAAGCCCCCGGGCAGTAAGCAGCCACTTCAGGCTGCGTGGGACTTGCCCGTGGTGGAGCCTAGGAGAGCCCCCTGGCTGGGCGTGGCGTTCCAGATTTCACGGCTGCTCTTTCCCACTGACAGTGTGGTGTGGACGCTGCCAAGGGAGTCTGGAGCCCCAGAGCGTGGAGGTGCAGGACTTCCAGGAGCGTCCGTCGCACTCCACCCGAGGGCGAGCACCTCACTCGCCGCAGTGGGTGGATGCATGCTGTGCCAGGCTGATGGCTGGCCCCCGGCCACAGGCCTGAGCGGGAGAGGATGGAGGGGAGGGATCAATGGTCCAGGTCCCCCTGGCCACCCAGCATTCATCCTCAGTCATGCACGGCCCAAGGCTTCGACACCCATTGATCATGGAAGGCCAGGTTCACCTCAAGGGCTGCCACATGGAGAGGTTAAGTCTGAAAAGGCTGAAAAGGCAGGGTTAAAAGGGCCTCCTGTCCAGATCAGATGGCACTGAATTCCCCAGGCAGCTGGCACGGCCAGTGGGAACAGGCGGTGAAGGCGCTCTTGGACATGGGGACGGGCACGCGGTGTGCACGGTGGGCGGGCAAGCATCTGGTGTCTTGTGCCTCCAGAGACCAGGTGGGAGGTGGAGGCGTTTGGTCCTGAGTGTCCTGACAGGTGATCCCACCTCCCACATCTCGCTCAGGTTCAGAGGAGGCAGCATGGGCCCAGGGACAGTTTTTGGCTTAGTCTTGCTCTTATAAAGGCTTCCGGGTCATGGCACCTGGGAAGGGGCCCTCGCTGCAGGCCCCTTCTAAGGACCCCCTCTTCCCACCTCTCCCCACCCTCTCTCTCTCAGCACTGCCTCCGGGCCTGCCAGGAGCAGATCGAAGCCCTGCTCGAGTCAAGCCTGCGCCAGGCCCAGCAGAACATGGACCCCAAGGCCGCCGAGGAGGAGGAAGAGGAGGAGGAGGAGGTGGACCTGGCTTGCACACCCACCGACGTGCGGGACGTGGACATCTGAGGGCGCCACGCAGGCGCCCGCCACCGCCACCCGCAGCGAGGGCGGACCCCGCCCCAGGTGCTCCACTGACAGTCCCTCCTCTCCGGAGCATTTTGATACCAGAACCCAAAGCTTCATTCTCCTTGTTGTTGGTTGTTTTTTCCTTTGCTCTTTCCCCCTTCCATCTCTGACTTAAGCAAAAGAAAAAGATTACCCAAAAACTGTCTTTAAAAGAGAGAGAGAGAAAAAAAAAATAGTATTTGCATAACCCTGAGCGGTGGGGGAGGAGGGTTGTGCTACAGATGATAGAGGATTTTATACCCCAATAATCAACTCGTTTTTATATTAATGTACTTGTTTCTCTGTTGTAAGAATAGGCATTAACACAAAGGAGGCGTCTCGGGAGAGGATTAGGTTCCATCCTTTACGTGTTTAAAAAAAAGCATAAAAACATTTTAAAAACATAGAAAAATTCAGCAAACCATTTTTAAAGTAGAAGAGGGTTTTAGGTAGAAAAACATATTCTTGTGCTTTTCCTGATAAAGCACAGCTGTAGTGGGGTTCTAGGCATCTCTGTACTTTGCTTGCTCATATGCATGTAGTCACTTTATAAGTCATTGTATCTTATTATATTCCGTAGGTAGATGTGTAACCTCTTCACCTTATTCATCGCTGAAGTCACCTCTTGGTTACAGTAGCGTAGCGTGGCCGTGTGCATGTCCTTTGCGCCTGTGACCACCACCCCAACAAACCATCCAGTGACAAACCATCCAGTGGAGGTTTCTCGGGCACCAGCCAGCGTAGCAGGGTCGGGAAACGCCACCTGTCCCACTCCTACGATACGCTACTATAAAGAGAAGACGAAATAGTGACATAGTATATTCTATTTTTATACTCTTCCTATTTTTGTAGTGACCTGTTTATGAGATGCTGGTTTTCTACCCAACGGCCCTGCAGCCACCTCACGTCCAGGTTCAACCCACAGCTACTTCGTTTGTGTTCTTCTTCATATTCTAAAACCATTCCATTTCCAAGCACTTTCAGTCCAATAGGTGTAGGAAATAGCGCTGTTTTTGTTGTGTGTGCAGGGAGGGCAGTTTTCTAATGGAATGGTTTGGGAATATCCATGTACTTGTTTGCAAGCAGGACTTTCAGCCAAGTGTGGGCCACTGTGGTGGCAGTGGAGGTGGGGTGTTTGGGACCCTGCGTGCCAGTCAAGAAGAAAAAGGTTTGCATTCTCACATTGCCACGATGATAAGTTCCTTTCCTTTTCTTTAAAGAAGTTGAAGTTTAGGAATCCTTTGGTGCCAACTCGTGTTTGAAAGTAGGGACCTCAGAGGTTTACCTAGAGAACAGGTGGTTTTTAAGGGTTATCTTAGATGTTTCACACCGGAAGGTTTTTAAACACTAAAATATATAATTTATAGTTAAGGCTAAAAAGTATATTTATTGCAGAGGATGTTCATAAGGCCAGTATGATTTATAAATGCAATCTCCCCTTGATTTAAACACACAGATACACACACACACACACACACACACACAAACCTTCTGCCTTTGATGTTACAGATTTAATACAGTTTATTTTTAAAGATAGATCCTTTTATAGGTGAGAAAAAAACAATCTGGAAGAAAAAAACCACACAAAGACATTGATTCAGCCTGTTTGGCGTTTCCCAGAGTCATCTGATTGGACAGCCATGGGTGCAAGGAAAATTAGGGTACTCAACCTAAGTTCGGTTCCGATGAATTCTTATCCCCTGCCCCTTCCTTTAAAAAACTTAGTGACAAAATAGACAATTTGCACATCTTGGCTATCTAATTCTTGTAATTTTTATTTAGGAAGTGTTGAAGGGAGGTGGCAAGAGTGTGGAGCCTGACGTGTGAGGGAGGACACCCGGGAGGAGGTGTGAGGACCAGGCTCCCGAGGGGAAGGGGCGGTGCCCACACCGGGGACAGGCCGCAGCTCCATTTTCTTATTCCGCTGCTACCGTTGACTTCCAGGCACGCTTTCGAAATATTCACATCGCTTCTGTGTATCTCTTTCACATTGTTTCCTCCTATTGCACGATCAGTTTTTTCTTTTACAATGTCATATACTGCCATGTACTAGTTTTAGTTTTCTCTTAGAACATTGTATTACACATGCCTTTTTTGTAGTTTTTTTTTTTTTTATGTGATCAATTTTGACTTAATGTGATTACTGCTCTATTCCAAAAAGGTTGCTGTTTCACAATACCTCATGCTTCACTTAGCCATCGTCGACCCAGCGGGCAGGTTCTCCCTGCTTTGGCGGCCAGACACGCGGGCGCGATCCCACACACGCTGGCGGGGGCCGGCCCCCAGGCCGCGTGCCTGAGAACCGCGCCCGTGTCCCCACAGACCAGCCTGTGTCCCTCTTCTCTTCCCTGCCCCTGTGATGCTGGCCACTTCATCTGATCGGGGCCGTAGCATCATAGTAGTTTTTACAGCTGTGTTATTCTTTGCCTGTAGCTATGGAAGTTGCATAATTATTATTATTATTATTATAACAAGTGTGTCTTACGTCCCACCACGGCCTTGTACCTGTAGGACTCTCATTCGGGATGATTGGAATAGCTTCTGGAATTTGTTCAAGTTTTGGGTATGTTTAATCTGTTATGTACTAGTGTTCTGTTTGTTATTGTTTTGTTAATTACACCATAATGCTAATTTAAAGAGACTCCAAATCTCAATGAAGCCAGCTCACAGTGCTGTGTGCCCCGGTCACCTAGCAAGCTGCCGAACCAAAAGAATTTGCACCCCGCTGCGGGCCCACGTGGTTGGGGCCCTGCCCTGGCAGGCTCATCCTGTCCTCGGAGGCCATCTCGGGCACAGGCCCACCCCGCCCCACCCCTCCAGAACACGGCTCACGCTTACCTCAACCATCCTGGCTGCGGCGTCTGTCTGAACCACGCGGGGGCCTTGAGGCACGCTTTGTCTGTCGTGATGGGGCAAGGGCACAAGTCCTGGATGTTGTGTGTATCGAGAGGCCAAAGGCTGGTGGCAAGTGCACGGGGCACAGCGGAGTCTGTCCTGTGACGCGCAACTCTGAGGGTCTGGGCGGCGGGCGGCTCCGTCTGTGCATTTCTGGTTGCACCCCGGCGCTTCCCAGCACCAACATGTAACCGGCATGTTTCCAGCAGAAGACAAAAAGACAAACATGAAAGTCTAGAAATAAAACTGGTAAAACCCCAGCGTGGTGCCTGCCTCTTTGCTTCCTGGGCTGGCCGTGAGCCAGGGACGCGTGTCCTGGTGCCCTAGAACCAGGGCAGGGTCGCAGGCTTGGCGGATGTGCGACGCCGCAGCCTGTCCTGTGCGCTCTGGGAAGTTCAGCAGCATCCTGACCTCCATCCCCGGGATCACAGTCACGCCACCCGCCGTGACAACCAAGAATCTCTCCTGACACTGCCACATCCCCCGGGGTGGGGACAGAATCCAGCCAGGAGCAGCCACACCCCTCCCAACTGGGAGGAAGCCCTCAGCACAGGTGTGTGAGCTGGGAGGCGGTGTCCTGTCCCCGGGAGGCTCCAGAGAATAATTTGCAGGCTGCCTGGCTGGGTGAGCCCACCTCCAACCACGCGAGACAACAGCTCCGGCCTGCGTGACGTGAGCGGTGCCCATTCATGGGGAACATCTTCCCCCTCTTCCTTGCCCCACCAGTTTGTCTTCCCGGGTTATTTGCAGATAGGAAAATAAATAAAGCCGGCATTCGTTAACCCTCTTCTGGCGCAAACTGCTGTTTGCTCTGGATGAATCATGGTCCTTTGGCCACGCCAGGCTCCGGGAGAGCAAAGCACCGTGTCAGGGCCATGATCCGGGGTGGCCTTTCACTGGGATCGTGGGGACCTGGAGGCCGCCTTATAGGACACCCATGACGCCCACCTCTGGATTTCAGGTGCACGTGACTGGACTTAACTTCAAACCCCAGGGTGGAGGCAGGTAGTGGGAGTGCCCTGGGAAGGTGTCCTCGGACCTTGGTCACTGCTCCTGAACCCATCTGTCAGGCTGGTTTGTCCTCATCCCAAGCTAAGTGGAAGCTCAGGTCCCAAGCCACCGATGGGTCCTACTTGTCAGCTGCAGGTTGAATCTCCGTGGCCTTTATGAAGCACCTGCTGTCTACCCTTCCTGCCTTGTAGAGCACTCCTCCCAGGGCTCAACAGTGGGGCCGGGGTGGTCGGTGTGTTGGCTCCACAGGCGCCTGCCCTGGGAGGAAGCTGGGGTGTGGAGGGAAACGCTTGGCCCCTGTAGGTCTCCACCAGCCTCTCCCCTGAGGGTGGGGGCTCCGGGAGCCTTCCTCGAGGGAGTCCTATATTGACTGGGTGGCGGAGCCTGCAAGGTGCCCCTGACACGTCACATCAGAAAGAGCTCAAGGGACAGTCGGAGCCAGAGGTGACACTGGTGGCCACTCGGGTGCCTCACAAGGCCCAGCTCCTCCTTGCTCCTGGGCAAATTACTCTCAAGGCAGGGACCAGGTCTGCACCATTGCGGCTCTCCAGTTCCAGGCAATGGCCAGGTCCTCTGTCAGGGCTGGGGTCCTAGGGAAGCCATGTCCCCACCCCCGCCCTGCAGCTGGGTTTACATTCATCCCCCGAGAGCACATGGGTGTAGCAGGAGCCCTGTGCACAGAGCTCCGACCATCGCACAGGGCACCTTTGGTTGTTTCACGGAGCAGGCAAGGGAGCCATCGGATCCTGTTAGGTTTGAGCAAGGATGTGGGGAAGAAGCTGGAGACCCACTTTGCCATGCAGGGAGAGGAGCACATGGGTCTAGGGATCTACTTTAGTGTTTGGAAGGTTTTTTAAGATGAAAGAGGGATGTGTAGGCTGATAGGTCTGGCAGAGCCAAAAGGCAGCGACATGTCTACTGGGAGAGATGGAGCTGAGCGCGGGGCTCAGGCAGGGTGGCAGGGCAGGGCCGGGGCCCTGGGTGGGTCAGGTGGGTTCACAGCCAAGTGTGTACAGAGGGCTTGGGCCCAGAGTGAAGCAGTTGCAAGCTCTCCCACAACCCATTCTCTCTGTCTCGGCATCTCTGGCATCCCGTCATGGGTGGGTCTGTACACACCCCACCCCTGGCTGTGCCACAATGGGGGTGTCTGTACACCCCTCACCCCTGGCTGTGCCACGATGGGGGGGTCTGTACACCCCCCATCCCTGGCTGTGCCACGATGGGGGGTTCTCTACATCCCCCAGTGATGGGTGGGTCTATACATCGTGGTTATGCCACGAGCTCCAAGGCTGTATCAGTCCGTTTTCACACTGCTAACAAGACATACCCGAGACTGGGTAAATTTATAAAGAAAAAGAGGTTTAATAGACTCACAGTTCTACGTAGCTGGGAGGCCTCACCATCACGGCGGAAGGCGAAAGGCCCGTCTTCCATGGCAGCAGGCAAGAGAGAATGAGACTCAAGTGAAAGGGGAAACCCCTATAAAACCATCAGATCTGCTGAGACTTGTTCACCACCATGGGAACAGTATAGGGGAAACTGCCCCATGATTCAATCACCTCCCACCGGGTCCCTCCCACAACACGTGGGAATTATGGGAGCTACAATTCAAGATGAGATTTGGGTGGGGACACAGCCAAACCATATCAAAGGCATCGTCTGGCCACTCTAGGCCCTTGTTCCCAACTCTCAAACTCCACTGACATCACCTCTGTGCCTCCAACCCCTCCTGGGATTCAGTGGAGACCTCGTCCCTTGTTGGAGTATCTGCGCTACCCAGAGGGTCATGGTAAAAACTGACCTTTGAGGAACTTCAGAGACAAACCCTTCCGCAGTCAGCTCTCCCTGCAGCCCCTTCGCAGAACCCTGTCCTCACACGCCCGCCACCCCTACCTCCCCTGCCTCCTGGCCCATCTCCCTGCACCCAGACAGTCCTCATCCATTCTTCATCCTCTGCCCCCAACCCCCAGCCTTCCTATCTCCCTTCAGCTCCGTCCAAGGTCCCTGGGACTCAGCCCCATCTCTCCCCAGCCTTGACCCCAATAAGCTCGATGTCTTTGCCCACCAGCTCCTGACACACCAGACTGCATCCAGCTTCCTGTTCTGCGCTTGGCCCACCGCCTCGGTCCACAGGAACCTTCATCTCTGCTCTGACTGTAAGGATGGGCTCTCTGAGGGCTTCCCCACCCCACAGCACGCAGGTGGTTCTGGGACTCTGGGATTGTCATGCCTGGGCACCTTCCTGCTCTGGCTGAGCCCCTCCAGGACCGAAATCTCCCAGATTTCTCTCTGCCTCCGTCTCCCCACCCTCCCATACAGTGGGTCCTAGGAAGGGGGCCGAATGGAAGGGAGGTCGTGTCGGCTCCTACAGGGCAGCCCCAAGCTGCTCCGCTGAGGTGCAGAGCCATGGGTCCAGCCTGACCCGCATGCCGGGAGCTGATTCCATGGCTCGAAGGGTCGGGGGTTCCCCAGGAGCCCAGACAGCACCTAGAGTTGTCACAAGGAGTGAAAGGCCCTGAGGGGACAGAGGAAGGAGGCTGGGCAGAGTGGGCACGTGGACTTCGGACCGCGCTTGTGGGATAACAGTGGCTAGGGCTGTGCAGAGGGTGGTGCACTCCCCATGGGAGTCCAGAGAAGCCAGGTCCAGTGGCAGTGGCATGCATCCGGCAATCCCTCCGGCTACCCTGCATGCAGCGTGACCCTCCTTGAAGCACCCCAGGAAGCAGTCACAGCCTCGCTCTGCCCAGCATTGGGGGCCTCCCCTCTCAATCTGGTGGGGAAGGCTGTGTTGCCTGCTGGCACCCGCTCTATCACCACTCCCACCATAAGCCTAGTCCCCAAAGTCAGCACTGCAGCCAGGGCCAGCGAGGGCCAGCAAGGGCACCCCTGTGCAGGGGCTGCAGCGTGGGGTGTGCGTCCCGCACTCTGGGCCAGCCTCGCAGCTCACACGGCTCTGTCATCCCAGGAATGTCTTTGATCAACACTTTATGCAAGACGAGGAAAGCAAGCCCAGGACCTCTAATCCGTTCCCACAGTCCCCTGCCCGCCAGGGCCCCACAAGCCCAGCGCCACACCGCCAGGCCTGAGCAGACAATAGCAGGCGGACGGGTGGGCGGGCAGCTCTGCGGCCGCTGGCCTTGGGGCCCACATCCGCGACCATTGTCACCGCCACTCACGAGGGCACACAAGGAGGGCTGGGGAAGAGAGAATGCAGAGCCCTCTGCTGAAGGGGCTTCGGTGGGCCTTGAGCCTTTCAAAGACGGCGGTGTCCATTAATCCTTTTAATTTGCACCTAGCGGCAGCTGAGACAAGCCTCTCAACCGGCAGCCACTTTAAGAGCTGAGTGGTCTAACCCGAGGATCAGCTCCTATTCCAGACCCTGGGCCCTCTGAGCCTGTCGAGGCAGTCCTCCTTGCCTTTGTTTAATCACGGGAGGAATCGCAGCTGGAGGTTACTGAGCACGCACTGTGTGCCTTGTGCTCAACACCGAACACAGTTTCTCTCTGAGTTTTGCAACCACCCCATGGGTTGGTGACAGGGAGGGGACACTCTGGTGGCAGCCACAGACACAGCCCTGCCCTCCCAGAGCCTACACTCTCCCGCACACAATCATCCCATCTGCTAGGTCAGGGATTGCCAGGTTTTCTGGAAAGGGCCACAGAGAGAGGCTTCAGGCTTTGTGGGCCACAGGTTCTCTTGCCCTGTGCAAAAGCAGCTGCAGCCGCTCTGTCAATGAGTGAGCATGGCTGTGTGCCAATAAAGCTTTATTTACAAAAATAGGCACCAGACTGGATTCAGGCTGACCCTCCTAGTTTGCCGACCCCTGTTCTAGATGAGTAAACCGAGGCCCAGAGAGCTAAAGTAACTGAGCCAGGACTGCACAGCTAGTGTGTGACCAAGCCAGCCTGGTGGGTCAGCCTCATGGAGAAGAAAAGGCTCAAGCTTCAAAAAGGGAAATGCACGGAGGCTTCATTGGGCCATTTGCAGCCAGGCCCCACCCACACAGCTCAGGGCCCTGCTTCGCCAGCTCCACCTGTTTCGAGGCTCCCAGTAGGTTGCCCCTGCGGGCGGCACTGTGTCTTGGCTGCTGGCCTGGAGAAGGGCAGCCAAACAGGCCGGCAGTGGACATCTGAGGGTGACCAGCTGTTTAAAAAGAAAACTCACCGGCATGTATACGCACACATTAAGCACACACGTTTTCCAGTAAAAGGCCCTGGCGTTGGATCTCGGATCTGCAGCTTTCCAGCTGTGCGGCCTCATTTCTCTGGGCCTCAATGTTCACACCTATAACATGGGGAAATCCTGCAAGAACACAGCCCATGATGGGGAGTCGTCTCCATCTCCTACTCACGACAACGACCAGCACAGAACGGGGGCTCCATAAATCTCTGTCAATAACTGAATTCTTTCTGGGGTGCTGAGGATTCTATGGCTCAATCTCTGTGAAGCACTGCTGAGCACCGAGCTTGGGGTGCAGTGATCACTCAGGGAACGCCATCATCCCCTCGGCGCATCCGCATAATCACCATCAGCATTCCATCCACTGCCCAGGTCTCGAAGCACAGGCCTCCATGCCACCGCGGCCGCCTGGGTGGTGCCACCAAAGCCGATCTTACTTCCCTCCTTTGCCACATTAAGTACACAGTTCTGGGTCTTCTTCACACCACGGATCCCCCCTCCTGGTGTTGACAGCACCCAGACTTTCCTCCAGCGAACCACCATTCCCAGATCTGTGCTTTGAGTGGGACCGAACCCATCCCCAGCTCCAGCCCAGGTCTTCATAGGCTGAAACCCAACTGCACATCCACACCCACCAGAAGAGCAGCAAGTTAATGGATGGGTGAGAAATCAAATAGAGCCATTGAGTCTTGAGGACACATTTTCTGCAGCTTCTGAAAAAGATAATGCTTCCCCCTTCCTTAGCATTCCCAGCAGGGAAACACAAGCCCAGGGGTGGCACTGCCCCCCTGCAGCCCTAAGGGAAGACTGAGCTGCTCCCAGGACCTCACAGGGGAGGCTGAGCGTAAGGCCAGCCCTGAGGGAAAGCAGGGAATGGGTCTCCAGACAAACTGCTGGATCAAGCCTCTCCTGAAGTCATCCCCCTTTTGTTCCAGAAGCCAATCATTGTCCTTCATTAAGTCAGTTTCATATGCGCACTGTGTCATTTGGTTTTCAAAGACACTTAACTATTACAGCTTCTGTGTGTTTTCTTTTTTTTTTTTGAGACGGAGTCTCACTCTCGCCCAGGCTGGAGTGCAGTGGCCTGCTCTCGGCTCACTGCAAGCTCTGCCTCCCGGATTCACGCCATTCTCCTGCCTCACCCTCTCGAGTAGCTGGGACTACACGCCCCCGCTACCACGCCCAGCTAATTATTTGTATTTTAGTAGAGACCGGGTTTCACCGTGTTAGCCAGGATCGTCTCGATCTCCTGACCTCGTGATCCACCCGCCTCGGCGTCCCAAAGTGCTAGCATTACAGGCCTGAGCCACCGCACCCCCCCGCTTGTGTGTGTTTTCTACCTCTTCTAGATCTAACATGTTATGATTGATATAAACAACAGGAGCGACTGACAAAGTTACCATGTGATCTTGGAATTTCAACATGCCTGTCTTGCTTAGCTGGGAGTTCCACAGGGTCAGGGAATGACTCCTCTTGGGGCCACCAGTGCCCAGAAGTATGCCTAGAACTGCTCTCTCTGAAGGGACAGGTCCCTCTTCCATGGCACACACTCTGTGTGTAACAGAGCACACGTGTGACCAAACTGACCTGGAGAAAGGGCCTGACCACATCCATATCCCAAGTTCTGAGGCCGGATAGTGCCTGCAGGGGCTGAGACCAGGGGAGAGGCTCAAGCCAGCCTTCTCTGGTGCACCCTGACTCAGTCCTCTGTCCACGGCAGCTGCGCCTCCCAGAAGGCAGAGGCCTCTTGGAGAGTGAGCCTTCCGGTCACAGCGCCTTTCGGGGCCTCCCGCCACTTGCCCTCAGTGGCGCCTGAGACCTGGGGGAGTCCAGCCAAATCCCTGAGGAGGCCCCACATGCAAGCCCAGAAGTGTCTGGATGGTGTGGCCGGCACCCTTACCCTCCAGACCAGCAAACGAAGCCCAGGCAGGGAGAGGGGCCTTGTAGTTTTCTGTGGCTGCTGTAATGAATTTTCACACACTCAGCAGCTTAAAACAACCAACATTTCTCTCATAGTTCCAGAGGCCAGCAGTGTCTGCAGTGCCCGCTCTCTCCCAGCTTCTGCTGGTTTCGGGCGACCTTCGGCTCTTCTCAGCTGGTCCATGTGCAHUMAN SEQUENCE - mRNA (SEQ ID NO: 17)GCAGTAGCAGCGAGCAGCAGACTCCGCACGCTCCGGCGAGGGCCAGAAGAGCGCGAGGGAGCGCGGGCCAGCAGAAGCGAGAGCCGAGCGCGGACCCAGCCAGGACCCACAGCCCTCCCCAGCTGCCCAGGAAGAGCCCCAGCCATGGAACACCAGCTCCTGTGCTGCGAAGTGGAAACCATCCGCCGCGCGTACCCCGATGCCAACCTCCTCAACCACCGGGTGCTGCGGGCCATGCTGAAGCCGGAGGAGACCTGCGCGCCCTCGGTGTCCTACTTCAAATGTGTGCAGAAGGAGGTCCTGCCGTCCATGCGGAAGATCGTCGCCACCTGGATGCTGGAGGTCTGCGAGGAACAGAAGTGCGAGGAGGAGGTCTTCCCGCTGGCCATGAACTACCTGGACCGCTTCCTGTCGCTGGAGCCCGTGAAAAAGAGCCGCCTGCAGCTGCTGGGGGCCACTTGCATGTTCGTGGCCTCTAAGATGAAGGAGACCATCCCCCTGACGGCCGAGAAGCTGTGCATCTACACCGACGGCTCCATCCGGCCCGAGGAGCTGCTGCAAATGGAGCTGCTCCTGGTGAACAAGCTCAAGTGGAACCTGGCCGCAATGACCCCGCACGATTTCATTGAACACTTCCTCTCCAAAATGCCAGAGGCGGAGGAGAACAAACAGATCATCCCCAAACACGCGCAGACCTTCGTTGCCTCTTGTGCCACAGATGTGAAGTTCATTTCCAATCCGCCCTCCATGGTGGCAGCGGGGAGCGTGGTGGCCGCAGTGCAAGGCCTGAACCTGAGGAGCCCCAACAACTTCCTGTCCTACTACCGCCTCACACGCTTCCTCTCCAGAGTGATCAAGTGTGACCCAGACTGCCTCCGGGCCTGCCAGGAGCAGATCGAAGCCCTGCTGGAGTCAAGCCTGCGCCAGGCCCAGCAGAACATGGACCCCAAGGCCGCCGAGGAGGAGGAAGAGGAGGAGGAGGAGGTGGACCTGGCTTGCACACCCACCGACGTGCGGGACGTGGACATCTGAGGGGCCCAGGCAGGCGGGCGCCACCGCCACCCGCAGCGAGGGCGGAGCCGGCCCCAGGTGCTCCACATGACAGTCCCTCCTCTCCGGAGCATTTTGATACCAGAAGGGAAAGCTTCATTCTCCTTGTTGTTGGTTGTTTTTTCCTTTGCTCTTTCCCCCTTCCATCTCTGACTTAAGCAAAAGAAAAAGATTACCCAAAAACTGTCTTTAAAAGAGAGAGAGAGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAHUMAN SEQUENCE - CODING (SEQ ID NO: 18)ATGGAACACCAGCTCCTGTGCTGCGAAGTGGAAACCATCCGCCGCGCGTACCCCGATGCCAACCTCCTCAACGACCGGGTGCTGCGGGCCATGCTGAAGGCGGAGGAGACCTGCGCGCCCTCGGTGTCCTACTTCAAATGTGTGCAGAAGGAGGTCCTGCCGTCCATGCGGAAGATCGTCCCCACCTGGATGCTGGAGGTCTGCGAGGAACAGAAGTGCGAGGAGGAGGTCTTCCCGCTGGCCATGAACTACCTGGACCGCTTCCTGTCGCTGGAGCCCGTGAAAAAGAGCCGCCTGCAGCTGCTGGGGGCCACTTGCATGTTCGTGGCCTCTAAGATGAAGGAGACCATCCCCCTGACGGCCGAGAAGCTGTGCATCTACACCGACGGCTCCATCCGGCCCGAGGAGCTGCTGCAAATGGAGCTGCTCCTGGTGAACAAGCTCAAGTGGAACCTGGCCGCAATGACCCCGCACGATTTCATTGAACACTTCCTCTCCAAAATGCCAGAGGCGGAGGAGAACAAACAGATCATCCGCAAACACGCGCAGACCTTCGTTGCCTCTTGTGCCACAGATGTGAAGTTCATTTCCAATCCGCCCTCCATGGTGGCAGCGGGGAGCGTGGTGGCCGCAGTGCAAGGCCTGAACCTGAGGAGCCCCAACAACTTCCTGTCCTACTACCGCCTCACACGCTTCCTCTCCAGAGTGATCAAGTGTGACCCAGACTGCCTCCGGGCCTGCCAGGAGCAGATCGAAGCCCTGCTGGAGTCAAGCCTGCGCCAGGCCCAGCAGAACATGGACCCCAAGGCCGCCGAGGAGGAGCAAGAGGAGGAGGAGGAGGTGGACCTGGCTTGCACACCCACCGACGTGCGGGACGTGGACATCTGA

[0333] TABLE 4 (mouse gene: Myc; human gene MYC) Mouse genomic sequence(SEQ ID NO: 19) Mouse mRNA sequence (SEQ ID NO: 20) Mouse codingsequence (SEQ ID NO: 21) Human genomic sequence (SEQ ID NO: 22) HumanmRNA sequence (SEQ ID NO: 23) Human coding sequence (SEQ ID NO: 24)MOUSE SEQUENCE - GENOMIC (SEQ ID NO: 19)CTTCCTTCTCCCTTCACTGAAACTGAACTGACCTTGGGATGGGGAAACCCCCACTTCATGGCACCCACTCTAAAAGATGGCTGTTGGTCAAACAGCCTAGCAAGCTCTAAACCAGGTACTCTGCACCTGCCCTCTGACGCCCTGGGATTATATGGCAGAGGGTAAGAACAGGAATGACATAATTAAAACCAGCCTCAGAAGCTGCTGAAGGCATTAGAACTAAAGCCCAGAAAAGCAACAAACTGTTACCATCAAAGCGTGAAAGAGGAAACGGTTAATCTTTTCAAGGGAAGTGAAGCAACTCGGAAGGCCATAGGAATCCACATCACCTGAACTGCAGACCAAGCCTTGGAACTGGGGCTTTCAAGCTACATCTGCTACTCACACCTTTGACCTCTCTGGGTGAATTGTTTTCTTACTAGTCACCAATGTTTTCAAACCTGGATTTTCACACTCCCTGCAATCCCTGGAAGGGCTCCTACCACCGGACCTATATTGCAGGGCCACCAACTGCCAGGTTCTCAGCCACAGCTCTTAGCTAGGACCAAGCAAATGGTCCCCAGTGTGTTACAGTCTCCTGTCCTCCAAAGTGAGTTCCTCAGATGCACTCCTTTCCAATCCTNNNNNNNNNNNNNNNNNNNNGATTTTCCTGTGGGCACATCAGCTTCCTATGCTGAAAAAAACAGAGAGTAGTAGAAAGGGAAAGCCTAATCAAGCCTGCAGCTGAGAGATTGCCCTGTGCCACAACCCCCAACTCCACCCCCTTATAGGACAGCACCTTACTCATTCAGCCAAAAGCTTAATGGATTGCCTTGATTCGCCTTGATTCCATAATGTAATTGACCATGAGTAGAGCAAGCTGCACCAACTCCTATCGTAAATGAAGACAGGGGTGAGACTGGAAGGGTCAGATACTGGAAAATCTGAGATTCTCTGCCTTGGTTTCTCATCTTGATCAGTTTCAACCAAAAAAGAAGGAACCTTTAACCAGGACTCCTTGTTTTTCTCAAAAGAATATGCTAAACTACACATTCCCATTATTGCTCATGAGACCTTGTTCATATGTCACCAACAATATTCACTGGTATATGTTTGTTCATACCTTCTTAAACATAATTTAACATTTCTTTATTTGATGTATGTGTTTTCCTTGCATAATGTATATGTACCACGTGTGTCCTTGTACCTGCACAGGTCACGAGAAGGTTTCAGTTTCCCTCGATTGATGACTGTGAACTATCATGTGTATGCTGTGAACTGAACTAAGGTCCTCTGTGGAAGCAACAAGTGTTCTTAACTGATGATCCATCTCTCCAGCTTCCGCTCAGAAATTTTCACACTTAAAGAAATAAGGGCTGGCTGGTGAGATGGCTCAGCGCTTAAGAGCACCGACTGCTCTTCCAAAGGTCCTGCCTTCAAATCCCAGCAACCACAAAGAAATAAGGGCAGGGGCTAGAGAGATGGCTCAGCAGTTAAGAGCACTGACTGCTCTTCCAGAGGTCCTGAGCTCAATTCCCAGCAACCACATGGTGGTTCACAACCATCTGTAATGTGATCTGATGTCCTTTTCTGATATGTCTGAAGACAGCTAAATTTTACTCATATACATAAAATAAAGAATTCTTTAGAAAGAGAGAAAGGAAGGAGGGAAGGGAGGAAGGAAGGGAGAGAGAGAGAGAAAGAACGGAAGGGAGGGAGGCAGGGAGGGAGGGAGGGACGNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNUNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNCCCTCCTCCTAGCTTTCTGAAGCCAGTCTTCTCCGGTTTCCCTTCAGAACAAGATGTAAAACTCTCAGCTCCTTTAGCTCCATCCCCGGACTGGATGCTGCCACACTTCCTGCCTTGATGATAATGAACTGAACCTCTGAGCCTGTAATCCAGCCCCAATTAAACATTGTCCTTTATAAGAGTTGCCTTGGTCATGATGTCTCCTCACAGCAATGGAAACCCTAACTAAGACAGCAGTTTAGCAGTAAATGGGGTGGCAGAGACAGGGTGATAGCAGGAAAATACTTTGACATAGCTAGTGAGACAGCAGGTAATGACAGTAGCCAAACCAGCCTGATAAACAAACAGCTAGCCCAGAATGCATAGCACAGCAGCAAAAACATTGGAGAACTGGCTCAATGACAAAGTGGAAGGAGGAAAGGCAATTCCTAAATGTTGTCATCTGATCACCATATCTGCACACTGAAGCACACACACACACAAATAAACAACACTTTAAAGAAATAAATATTACATGATGATTGCAACAACCACAGGCCATCGGAAAAGAAAGAGGAAAAAAAATCAATGGAGCAAAGAGACCAGGCTGCACACACAGGAGGAACATCAGGAGACCCAAATTCACCCAAATGTTCTCAATGTCAGCATGTTTGCATCTAGGTCCCACACTCTAGGGGATTGGCAGGATCCCTGACCCCGACTCACTAAATACCAATAGGAAGCCCCAAAACCCCCACCACCTATAACAACCTCAAATATCTCCTCCTGTTGGTCAATGTCCCGTGGAAGCAACATTACCTCTAGTTGAGAGGTACTGATCTCTAGAATCCAAAAGTGTCAGCATTTCCAGAAGCTTTCCCAGCAAACCAACAAAAAGAGATGOTCTCACGGTCACCGGTTGTGGGGAAGATAGCTTGAGTGCCTTTAGGGAGGTTCATTCAATGATAAAGTCCACATACAGTAGTCAGGAGGGAATGGAGAAGGTAAAACTGAGACCAAGCAAAGGCTGAGCTGCACTCAAATTCTACCTACAGAAGTCAAGAGCTGTGACCCATAGTTTGGGGTCTGTTCTAGCCAATAAAGACGCACAGGCTACTATTGCACTGGCTTCTAAATGAAAGTCAAAGATTACGGACAGAAAAAAAGGAAGAAAAAAAAGTAAAAAAGAAAGCAAGACCCGTCATGCACCTCCTCCCCAGTCACCTTTACCCCGACTCAGCAAGGGTCCATCATCCAGACAGATGCCGCCCAAAAGGACCATCACAAAGGCCGGCCAGTGAACAAAAGTGCAAGATTGACTTGGGTTTGCCATTTACAGAACAATAAACGAAGCCTTTGAAGCACTGTTAAACAAAAGAGCCATTTGTCTATGCTGGTGGCTACAAAGGAGAACAGGATTGCAGCAGAGGACTAAGAAAAGAAAGAGAAAATGCCAAACTGAGATGTGCCTGGACTTTACCGGGTCCTGCCCAGAGACCTTATATGCCAGGACCTAAGATCTAAAAGCCACTGGGTAAGAAAACAATCAAATATGCTTAATGCAATACAGGCAATGTAGGTTCTTGGGTATTGTGTTAAAAATATCTACTAATTTTTTTTCCTTGTCAGCTGCTTTAATTTATGCAGTATGGGAAGGGATCACATCGGAAAAGACAAGGGAAGAACAGAAAAGAAACACCGTACATTTTCAAATGCACAAAGATCTCATGCACTGCCTTCTGTTTCTGTGCCTATGAATTAGTGATGCTAAATTTTATCTTATTTTCTTGCCTGGTGCGGCGGGCGGGGAGGGCGGGGAGGGTGACTGTGTTCCTCTCTGTGGTGGCATAGCTGCCATTTACATGCCTGTGAGGTCCTCTTTTCCTTTAGCATGCCATGGCTAGCTTGGTTTTTAATCTAACAGCGCTTCTTTCCAAATGATGTTTCTGCCGCAGACAGGTATTTATCATTGTCTTTGCTCTOGTCACTTCCCGACAGCACTCGTGAGAACTGAAGTAATTTTGAAATCGTAGCCCGTCCTTAGGGTCTCCTGCTTCTCTCCCGAGTAGGAGCTAGGTTTTTGATCCAGTTTGTGTCGATTTAGTGACTGTTTTTATACATGCAAAAGGTTAGCTCAGTGGTGATGGTTGCGGGGGGGGGCTCTTTGGCATGCAGAAAAGAGATTCAAGAACATTCGGGGATGTTATCTAGTGGTTTTCTCCTTGTTCTTACAAGAGTGACTTTCGAGAAGAGGGGTATACTTTGGCTCACAGTTTGACGGAAAAATCTGGGATCGAAGAAGTCATTGTGGGAGCAGCTGGAAGCTTTGTCACTTGGGGAGCCTTGTCATACTCTAGCCAAAGTTAGGAAGCAGGTTGGAGGGTGGGGAGACAGATTCTCGAGTTTGGCGCTTCTGTTTTATACCTTCTCTACCCACATTGTGAATAGACCTGACCCCTGGGTTGACACACATCACATTAGTGTGAGTACCTCTTCCTTCTACACATATACCTCTCTACAAATACCCTCATAGGTAACACCACATCTGCATCTCCTAAGTCATCAAGTCGACAATCACACTAACCATCATAGGCAGGGCTGCAACACACCTTGAATCCCGTGACTTAAAGACGCAAAGACAGGTGGCTCTCTGAGTTCAAGGCCTGCCTGGTCTACAGAGTTTCAGGACAGTCAGGGAAACCCTACCTTGAAAAACAAAAAACAAAAAACAAAAAACAAAAAAAAAGAAAAGAAAAGAAACACCCAAATTAAGCGTCTCAAGGATGACCGTTCTTGGTATGTTATTCACACCACATATTTGGACCTCCCCTCTTGTCTCTTTGCAAAGTAAGATGTTGGCCCGACTTGTTCATTCTAGCTGGCAATATACAGTTCAGTGACTGAATGAATGCTGACCACAAATCAGGCCCTGTTTCAATACTGAGCACACCTTCCTCTCCTTCCCATAACAGCCCTTTCTTTCTGGAGGTCTTCCTTTTTTTCTTAAAAATGTAAGAGCATCATCACTGTTAGTATGAGACAGTCACGTTCTGCGCACTGTGATTCTTACTTTTTCATACTGTAAGAGGGAATCTACTCTCTGCCATCGGGACACCCAGTGGAACTGCTCACCTGGAGTCTTCCCTCCACGAAGACTAGGATCTTCTGGAAAGCTGTGTGCTTTGGACATCTAACTCACATCCAGCAATAGCTCCCAGAAAAGGACCTCAGAGTTACAACGTTCCAGAGGAACAAAACAGTGGGACATCTTCCACCATCTTCCAAAAGGAAACCTCAGAACAGAACAAGCAACCTTTGTCCTTAGTAAGCTTGTCCACAGAGGCACGCATGGCTGTCATCCGAACACTGGGAAGTCCAAGGCAAGCGAACAGCAAGTTCAAAACTAGCTTGAACTGGCTGCATAGTGAGGCCCTATCTCAAAACATCACCCGCTAACTATGTACCTCACAGACAAGCCCTTGTCCACTGTTTGAAGACTCTGGATTTGATTCCCAACAAAATAAAAACAACAACATACACTCACATACTCACACACACACACACACACACACACACACACACACACCCAACTCCTTCACTAAAAAAATTTAGTGTAGGTAGAGTGGCACAGGAAACTCTAAATTCCAGCACTACACCCTGAAGCAGTTTTTATTTTAGTTAGTAACCCATCCTAGGCTACCTTCTCAACAAGAACATTCCAATCACTACACTTTATTGACAAGATTATAAACTTGTGGCTTTCCTGTCCTTTTTAAAGTATTTTTTAAAATTTATTTTACAATGAACTGCTACCCTTTCATTTCCTAATATGTATGGGGATGTCCCCTACCTTCCTCTTACTTAAAAAAGCAAACACCCCGGGTGATGTCATCAGGCTGGGGTACAGTACGGGCAAAGTCCCCCCACAGGCTATTCCAACTACCTCGGTTCCCACACCTACACTAAAACCGGCATCATTTGGACGTAAGATCTTAAAATAATCCATAATTACACCTTTTCAAAAAGCACCTTTTGAGCGTCACCTCTACCCACTGTCATATCTGTTGGTGCTGTCCTGTGTTTAGGGAGAGGCAGAGAGAAAGCGGGTGTGCGCAACCTCTAAGAGAGTAATAGTAAAGAGACAAGCCTACGAAATCTTCCCCAAGAGGCCTTTTGGGGAAGGCTATCCCCCCTTCCGTGGATGTTGAATACCTTGCCTGTTGCTCAGATGCAGTCAAGCATCTGATGATGCTTGAGGCATGATGCTGACACCACTGTGTAGGTTGCTACAAATTCCCTTTCTATTATACCCACCCTTATGCAGTTATTTGGGTTTAAATTTTCAACGTTTTAAAAAAAAAAAAAAAAAGTATTGCCGGGCAATAGTGACGCAGGCCTTTAATCCCAGCACTCGAAAGACAGAGGCACGCACATCTCTGAGTTTGAGACCAACCTGGATGGTCTAAGGCCTTGAACTCAAAAGATCTATCCACCAGCTTGTATCCCATTTAATTGAGTGATTTGTTTGCTCTCTCTCTCTCCCGCTCCCCCTCTCTCCCCCCTCTCCCTCCCCTTTTTCAGTTCTTTATTTATATTTGAATATTATCTCTCTCTCAGATGTCTACTTGGTGACCGTCTTTTCTACAAAGGATTATCTCTTTCATGACACGCCATTTATTAATCTCCTTGTCCCTGGAGCTTCTGTACAGTAGCCTCACCTGATCCTCTAGCTTCTCCATCCCAGATGATTGGGATTCAACGCATTCATCACCACGCCTACCTAAAATTCCAACCTTTTAATAAATGGCTCTCTTAAAATATTTTGGCAAGGAATCTCACTCTTTCTCTTCACTAAATATAGTTCAACCACCCAATTCGTAACCACTCGGGCTGAGGGTGAGCATCCTTAAGAACATAAGCAAAAAATTTGCAGGCTCAAGATTCAGTTTAGTTGCTAGAGGGCTCACATAGCATGCCCTCCCCACCCCCGATTCCATTCTCATTTATCGAGGCATAAGGCCAGGTGTGGTGGGATATGTGCTGGGATGCATAAGATCTTTTATAAAGAAGAGGAAGAGGAAAAACAGTTATACAAAACTAATAAAACTGTGTGAGTTTCAGGCTAGCAAAGAATAGTCGTGAGAATCTCTCTCAAAAAAAAAACCCCAAAATAATAATAATGATAATAATGATAATAATAATAATAATAATAAAACAAGCCAATAATAAGCTAATGCTCCTGCCTTGCATTCTGACTCCTTTTGCCCAGTTAAATTCAATGCTCTGCTTTGACACGTCCAGCTTACAACACGACAAAGGTGTGAGACATGCGTGCTAAAACTTGTTCTATTGCCTTTCCGTTTCTGTTAGATCTCCTTCACTTGTATACCTGTGACTCATTCATTTTCCCCATCCACAACTAGGGCTCTGTTTTGGGTGACTGTCAGAAAGTAGGGATGGGTTCATCTACTCCCCCTCTTTGCAACTGAATAGCCACCTCTGAACCATTTTTTTCTCTAGTAATTTCTCTTCCTTTGCCTCCTTTGCAGCCTAA3AACAGTCATTTAAGGATGACCGGAAGCTTGTCTTAGGCAAGGAAGCATCTTCCCAGAACCTGCAAACCCTGCAGCCCTGCCCCCATCCGACCTCCGCCCTCGTTGGCTTCGCAACGCTGTGGTCTCTGTGGCCAGTAGAGGGCACACTTACTTTACTTTCACAAATCCGACAGCCACAACCCGGGTGGTGGGGGGTGAGGGGGCGGGGAAAGAGTCTCTGCAGCAAAACGCAGACTAGGGATTGGTGGCTCTTGGTGTTTGAGGCAAAATCCTAGAGGCTGTAGTCATTTTGCAATCCTTAAAGCTGAATTGTGCAATGAGCTCGATGAAGGAAGATACTATCATTCAACAGCTGAATCCTAAATTGCAAACTCAGTGGCTAATAACAACTTTGAACAATGAGCACCTTATACACGCTACTGTATTTTCTTTTCTTTCTTTTTTTTTTTTTTTTTTTTTTTTAAACCGGGTAGCAGTGAGAGAGGTTTCTTTAAGTGCCTTGGGCCGACGAGTCCGGAATAAGAAGACTTCTTTGGGTTTTAAAGTGTAGGATAAGCAAATCCCGAGGGAATATGCATTATATAATAAATCTAGAACCAATGCACAGAGCAAAAGACTCATGTTTCTGGTTGGTTAATAAGCTAGATTATCGTGTATATATAAAGTGTGTATGTATACGTTTGGGGATTGTACAGAATGCACAGCGTAGTATTCAGAAAAAAAGGAACTGGGAAATTAATGTATAAATTAAAATCAGCTTTTAATTAGCTTAACACACACATACGAAGGCAAAAATGTAACGTTACTTTGATCTGATCAGGGCCGACTTTTTTTTTTAAGTCCATAATTACGATTCCAGTAATAAAAGGGGAAAGCTTGGGTTTGTCCTGGCACGAAGGGGTTAACGGTTTTCTTTATTCTAGGGTCTCTGCAGGCTCCCCAGATCTGCGTTGGCAATTCACTCCTCCCCCTTTCTGGGAAGTCCGGGTTTTCCCCAACCCCCCAAATTCATGGCATATTCTCGCGTCTAGCGCCTTGATTTTCCCCACCCCAGCTCCTAAACCAGAGTCTCCTGCAACTGGCTCCACAGGGGCAAAGAGGATTTGCCTCTTGTCAAAACCGACTGTGGCCCTGGAACTGTGTGGAGGTGTATGGGGGTGTAGACCGGCAGATACTCCTCCCGCAGGAGCCGGGTAGAGCGCACCCGCCGCCACTTTACTGCACTGCGCAGGGAGACCTAACAGGGGAAGAGCCGCCTCCACACCACCCGCCCGCTCGAAGTCCGAACCGGAGGTGCTGGAGTGNNNNNNNNNNNNNNNNNNNNNTGACGCGGTCCAGGGTACATGGCGTATTGTGTGGAGCGAGGCAGCTGTTCCACCTGCGGTGACTCATATACGCAGGGCAAGAACACAGTTCAGCCGAGCGCTGCGCCCGAACAACCGTACAGAAAGCGAAAGGACTAGCGCGCGAGCAAGAGAAAATGGTCGGGCGCGCAGTTAATTCATGCTGCGCTATTACTGTTTACACCCCGGAGCCGGAGTACTGGGCTGCCCGGCTGAGGCTCCTCCTCCTCTTTCCCCGGCTCCCCACTAGCCCCCCTCCCCAGTTCCAAAACCAGAGGGCGGGGAAGCGAGAGGAGGAAAAAAAAATAGAGAGAGGTGGGGAAGGGAGAAAGAGAGATTCTCTGGCTAATCCCCGCCCACCCGCCCTTTATATTCCGGGGGTCTGCGCGGCCCAGGACCCCTGGGCTCCGCTGCTCTCACCTCCCGGGTCCGACTCGCCTCACTCAGCTCCCCTCCTGCCTCCTGAAGGGCAGGGCTTCGCCGACGCTTGGCGGGAAAAAGAAGGGAGGGGAGGGATCCTGAGTCGCAGTATAAAAGAAGCTTTTCGGGCGTTTTTTTCTGACTCGCTGTAGTATTCCAGCGAGAGACAGAGGGAGTGAGCGGACGGTTGGAAGAGCCGTGTGTGCAGAAACCGCGCTCCCGGCCGACCTAAGAAGGCAGCTCTGGAGTGAGAGGGGCTTTGCCTCCGACCCTCCCGCCCACTCTCCCCAACCCTGCGACTGACCCAACATCAGCGGCCGCAACCCTCGCCGCCGCTGGGAAACTTTGCCCATTGCAGCGGGCAGACACTTCTCACTGGAACTTACAATCTCCCACCCAGGACAGGACTCCCCAGGCTCCGGGGAGGGAATTTTTGTCTATTTGGGGACAGTGTTCTCTGCCTCTGCCCGCGATCAGCTCTCCTGAAAAGAGCTCCTCGAGCTGTTTGAAGGCTGGATTTCCTTTGGGCGTTGGAAACCCCCGTAAGCACAGATCTGGTGGTCTTTCCCTGTGTTCTTTCTGCGTCTTGAATGTAGCGGCCGGTTAGGACACTCTTTCTTCCATTCCTGTGCTTTTGACACTTTTCTCAAGAGTAGTTGGGGTAGCCTGGCCTAGATCTCAGTCGGGCTAGAGCGACTTGTCAACATGACAGAGGAAAGGCCAAGGGAAAAACCGGGATGCATTTTGAAGCGGGGTTCCCGAGGTTACTATGGGCTGACGCTGACCCGGCCGGTTCGACATTCTTGCTTTGCTACATTAATTGATATGTGTCCTTTGAGGGGTCAAACCGGGAGGTCGCTTCGTGGTGGCCAAAGAAAGCCCTTGGAATCCTGAGGTCTTTGGAGAAGGGATTACCTTTTGCGTTTGGGAGCGAGAAGGCTCCGTAGCTTCTGACTTACCAGTCTCTGAGAGGGCATTTAAATTTCAGCTTGGTGCATTTCTCACAGCCTGCGACCGACACGGAGGTGCGTCCCGCCCGCCAATCCCCGGCGGCCATCGCAACCCGTCCCTGAGCCTTTTAAGAAGTTGCTATTTTGGCTTTAAAAATAGTGATCGTAGTAAAATTTAAGCCTCACCCCCGCGGCACTAGGACTTGATGTTGGGCTAGCGCAGTGAGGAGAAGCAAAATTGGCACAGGGATGTGACCGATTCGTTGACTTGGGCCAAACCAGAGGGAATCCTCACATTCCTACTTGGGATCCGCGGGTATCCCTCCCGCCCCTGAATTCCTAGGAAGACTGCGGTGAGTCGTGATCTGAGCCAGTTCCGTACAGCTGCTACCCTCGGCGGGGAGAGGGAAGACGCCCTGCACCCAGTGCTGAATCGCTGCAGGCTCTCTGGTGCAGTGGCGTCGCGGTTTAGAGTGTAGAAGGGACCTGTCTCTTATTATTTCACACCCCCTCCCCTTTTATTTCGAGAGGCTTGTGATAGCCGGAGACTGAGCTCTCTCCTCCAAGTCAGCAATCGGAAAGAAAAGCCGGCAAAGCCCCTCCCCTTTTATTTCGAGAGGCTTGTGATAGCCGGAGACTGACCTCTCTCCTCCAAGTCAGCAATCGGAAAGAAAAGCCGGCAAAGCAAGCAAGGGGGCGCGCTGGGCGTGGAGAAAGAGGAGGGCGGAGAGGGGCGGCGCCGCCGGCTGGGTACGAGCGCGGCGACGGCGCGAATAGGGACTCGGACCCGGTCGGCGGCCCAGACAGCCGGCACACGGGAGGGGGCCGAGCGACGCGGCGCCTCTCGCCTTTCTCCTTCAGGTGGCGCAAAACTTTGCGCCTCGGCTCTTAGCAGACTGTATTCCCTACAGTCGCCTCCCTCAGCCTCTGAACCCAAGGCCGATCCCCATTCCTGGGCGTCTCCAGGGCTAAGTCCCTGCTCGAAGGAGGCGGGGACTCGGAGCAGCTCCTAGTCCGACGAGCGTCACTGATAGTAGGGAGTAAAAGAGTGCATGCCTCCCCCCCAACCACACACACACACACACACACACACACACACACACACACACACACACTTGGAAGTACAGCACCCTGAACGGGAGTGGTTCAGGATTGGCGTACAACGCTGCCCCAGGTTTCCGCACCAACCAGAGCTGGATAACTCTAGACTTGCTTCCCTTGCTCTGCCCCCTCCAGCAGACAGCCACGACGATGCCCCTCAACGTGAACTTCACCAACAGGAACTATGACCTCGACTACGACTCCGTACAGCCCTATTTCATCTGCGACGAGCAAGAGAATTTCTATCACCAGCAACAGCAGACCGAGCTGCAGCCGCCCCCGCCCAGTGAGGATATCTGGAAGAAATTCGAGCTGCTTCCCACCCCGCCCCTGTCCCCGAGCCGCCGCTCCGCCCTCTGCTCTCCATCCTATGTTGCGGTCCCTACCTCCTTCTCCCCAAGGCAAGACGATGACGCCGCCGGTGGCAACTTCTCCACCGCCGATCAGCTGGAGATGATGACCGAGTTACTTGGAGGACACATGGTGAACCAGAGCTTCATCTGCGATCCTGACGACGAGACCTTCATCAAGAACATCATCATCCAGCACTGTATGTCGACCGGTTTCTCACCCCCTCCCAAGCTCGTCTCGGAGAAGCTGGCCTCCTACCAGCCTCCCCGCAAAGACAGCACCAGCCTCAGCCCCGCCCGCGGGCACAGCGTCTGCTCCACCTCCACCCTGTACCTGCAGGACCTCACCGCCGCCGCGTCCGAGTGCATTCACCCCTCACTGCTCTTTCCCACCCGCTCAACGACAGCAGCTCGCCCAAATCCTGTACCTCGTCCGATTCCACGGCCTTCTCTCCTTCCTCCCAACTCGCTGCTGTCCTCCCAGTCCTCCCCACCCGCCACCCCTCACCCCCTAGTCCTGCATGAGGACACACCGCCCACCACCAGCAGCGACTCTGGTAACCTACCCCATTCACAGCAGGGTAGGAACCGAGAGGTTCGATCCACCTCCTTCTCCACCACTCATTGGCATTAATTCAATTGGCCTCCGGGGCTCCCCCTTTCTTTCCCTTCTGTCTAACACCTCTTCATCCCTGGATTCCCGTCNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNAANNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNTCAGGANTTCATTTGGGTTTTTAAATCTTCTGGCTTATCTTTCAGCTCCATCCACTCCCTTTACCCCTCCTAACCATTTTAATTACCCTGCCAAGGGTGTGAATGACCATAAACCAACTGATCTGGAGGGGGGTGAATTACCTGCTTCTTTTCTTGACTGCCAGAAGAATATTTGAATTTAATGCATACGTTTAATCTAAGACCCAAGAGAAGCATCACAGAACCTGGGACACCCTTTATACCCTTAGAGCCACGCACTAGTGAAAGTTCCTAAAGAATTGAACACCTGCGCTCTTTTGGGTGTTTTGTTTTGCTTTGTTTTTTCGTCCTCTTTTGAACACTTCAAAGCAAATTCTGTTCAATTTCGACTTCTCCCCCCGTCCCAACACTCCCCCAACACCAGGACGTTTGCCAAAGCTGCAAGACTTTTTTTTTTTTTTTTTTTTTTTAATTGTGCTTCCAGTAAAATAGGGAGTTCCTAAACTCATACCAAGACATTTGCAGCTATCCCTCACGGGACCTGAAAGGTTCTCGGTAAATCCCTTAAAAATAGGAGGTGCTTGGGAAATGTGCTTTGCTTTGGGTGTTGTCTCAAGCCTCATTAAATCTTAGGTAAGAATTGGCAAGGATACCATATCCTGGTACATGGTAATTTTCTCACCTGTCCCCTAACCCTGTTCTCCCTTTCTGCGAGAAGGGAAGATCGTGTCTGGATCTGATTCTTACTTTCTTCCCTTTCCAACTTGGTATTTGGATAGCATCGGTCAAATCCTATGTATAGCGTCCGGGATTCAGGAGCAACGTGGCTAACTGTGATCTTCCACTTCCTCCCTTACAGGAAGAGCAACAAGATGAGCAAGAAATTGATGTGGTGTCTGTGGAGAAGAGGCAAACCCCTGCCAAGAGGTCGGAGTCGGGCTCATCTCCATCCCGACGCCACACCAAACCTCCGCACAGCCCACTGGTCCTCAACAGGTGCCACCTCTCCACTCACCAGCACAACTACGCCGCACCCCCCTCCACAAGGAAGGACTATCCAGCTGCCAAGAGGGCCAAGTTGGACAGTGGCAGGGTCCTGAAGCAGATCAGCAACAACCGCAAGTGCTCCAGCCCCAGGTCCTCAGACACGGAGGAAAACCACAAGAGCCGCACACACAACGTCTTGGAACGTCAGAGGAGGAACGAGCTGAAGCGCAGCTTTTTTGCCCTGCGTCACCAGATCCCTGAATTGGAAAACAACGAAAAGGCCCCCAAGGTAGTGATCCTCAAAAAAGCCACCGCCTACATCCTGTCCATTCAAGCAGACGAGCACAACCTCACCTCTGAAAAGGACTTATTGACGAAACGACGAGAACAGTTGAAACACAAACTCGAACAGCTTCGAAACTCTGGTGCATAACTGACCTAACTCGAGGAGAAAGCTGGAATCTCTCGTGACACTAAGGAGAACGGTTCCTTCTGACAGAACTGATGCGCTGGAATTAAAATGCATGCTCAAAGCCTAACCTCACAACCTTGGCTGGGGCTTTGGGACTGTAAGCTTCAGCCATAATTTTAACTGCCTCAAACTTAAATAGTATAAAAGAACTTTTTTTTATCCTTCCCATCTTTTTTCTTTTTCCTTTTAACAGATTTGTATTTAATTGTTTTTTTAAAAAAATCTTAAAATCTATCCAATTTTCCCATGTAAATTGGGCCTTGAAATGTAAATAACTTTAATAAAACGTTTATAACAGTTACAAAAGATTTTAAGACATGTACCATAATTTTTTTTATTTAAAGACATTTTCATTTTTAAAGTTGTTTTTTTCATTGTTTTTAGAAAAAAAAATAAAATAATTGGAAAAAAATACAATTGGGCCAACTTGTGTTTTCTTTTTCCTCTTCCTCAAACTTCCTTTCCTCAATTACAGATTAAAGAATTTCACCATTTTCACAGGGTAGGTTTACAAATATGGGAAGGGGTTATCATTGTTAAAATGGGGCTGGGGGTCCTCAGGATTTCTAAGTTGTCTACAGGATGCTTTCTGTGGATAGTAATAAAAACCAGAGCTGTTAGTTAGGAATGGGCAAAAGGCAAGTGAGAAGGCTAGATGCAGGGAAGGGAAAAGCAAGAGGTTAAAGATAACAGCTAAATATACAGGAGGAAGAGATGGCAGAATCTCCTACACTTAACCGAAGCCATTCCCTGGTTCACCTCAACCCAAGGACTCTGCCCTGCCAAAGAACTGGTGAGGGGAGGGAGAGAGAACCACCGTTCATTCCTTGCCTCTTGCTCCCAGGTGATAGTCCCTTCACATCAGTATCTCCTATGCTTCTGAAAAAAACAGACGAACAGCATTACCACTGCTAAGTTGATCCTGGTTTTCCAAACAACGACATACAAAGGTTCAGAGGGTTGCAGAGCTTAATGGGTACGAACACAACAAAAATAACCCAGGGCCCCTGTCTTGAAAACAAGCCTTGCTGCCTTGCTTAGTTGGGTGTCCTTCCGCTGGTTAGGGGTCTGAGAATGAGCGCTACAGGCTCCATTAGGAGCTTTGACAGAGTGCCACGAAAGAGGTACTATGATCTCTTTATACCTAGTACAGGTACAAACAGACATGAAATAACCCATCCATGCACCCAGGGGATTCAAAACCACTTTATCCTTAGTGCATCCAGGAGGAAGATCCTAGCTACGAAGGAGAGGGCAGGAGTCATTAAAGCTTCACTACTCAAGAACTGGTAGACTTCAGTTCCCCTCCTTGTTTGTGGATTGGGGGGTTGGGGTGGAGGGTGTTGTGTGTACTCAGAGGCACATAGCTCACTCCTACCTTACCCACTTAGTTTTTAACATCAGATCCCTGCTTGCTCCTGGGAAGAAGCCAGTTTAGAAGTGCTACTGGTCACATCATAAAATAAAACCTTGTTTTACATGAGTCATTATTTTAGAAATTGCAAGCTCGCCTTCCTCCCAAGCACTTTCACACACTCATGACACACGCTCATCAATGGCCCATGAGAAAGCCTTTTGGAACAGGTATCTTATTAATTATAAGCCTCTGAAAAGCCACAATCCAAACCAGAAACTGAAACATGTACGTAAAGTCCAGGGAGAAAGGTACCCTAAATGTCCTAAATGACCCCATTGTCTCAGAGAACGTCTCTAGCATCCTGGAGTGTCTTTGGGACTTTAATTCACCATCATTCATAAACCAATAAGTAATTACTATCTTTGACACCCCCCCCCCATGATCTATTGAAGCGTTTAACATTTAGTTTTTGATCTTATTTTTGGCTCTTTTAGACTCACCCTCACCTTCAAACTGTTACACCCTCTATCCTACATTCAAAAGAAAACACAAACCCCAGTAGTAGTTTGAAATACTTTGAGTAGTTCAAAGGATTAGCAAAAGGGGGCAGCAGGGGGTGCTCTTAAATAGTTCCCTCTTTTTCCCCTTTGTGAGCCTAGGCTGCACTGCACCCCTGGGGTGACTCACTTGAGACCTGGGAAGGTGTTAGGTTGAATCACTCAGTCCAGGCAAGCCCAAAGAATAGAGGAAAGCATTCCTCATTAGGAAAACAACTCCTGTTCCAAATGATCAGGAAACAAGTTTAGAGATTCAGATTTGGCTGTGGGGATGGAATCGAAGTATCACAGCTCCCTATCTGGGCACTTCTCAGCTTTACCAAGCCAGGGAATGGTCTGAAAACAGGACATCGGCCAGCTTCCTTCCAGAAAGTCAGGCTGATCTTGACCATAACACACGAAGGCTCTCCCAGCCAATCTGGAGTCCCAGGGGTCTGCAACATTCTGCATCAATTTATAGATAACAATCACGATGAGGGGTGAAGTGGGAGGAGCTTTCAGCTTGCAATCTGGGATATACAAGAATTAGCTAGTCTCTTCTGTTGTTCACCCATGACACTCCAACTCAGTTTCCCCGAGAGGATCCCTGGGATGGTGCTCTTCAGGATAAACTGAGTGAGGAGGAAGTGTGACTTTATGCTATCATTCGGGGACAACACTAAAAAGCAATCAATTACACTTTAAGTTGAACAAAAGTTTCACAATACCAGGATAGTCCTTCAGTCATCCAAAGCTTGAACACGTATGTAGAGTCTTCTGCTGTTCTTTAAGATGGACTTTGGCACTAACCTTGGAAAAGAGGGCCAAAACCCACCCCCCAAAAACAAACAGAACAAAAAACGTGAAAGAAGATTTTCTGTGGTTTGTTTACAATAAGAGATGAGTCACAATAATGATTTTTTTTTTTTTTTTTAGCATGACTGCTAAGGAACCCTGAAGCATTTCTTCCCAACAAAAACTAATCTTTAGCTTATAACATGCTGGAAGATGAGCTTCAAGCCTCTCTATAAATACATCACTGGGTATCTTCAGGGAACAAACTCTTCACTTAAGGTTAGAGACCATCCTGGATCGATTTCAAGAACAGAGGTTTATTTTAAACAATGAAGCCTCGGCTACAGATCTCGTTCAGTGATAAGACACTTGTCTAGCATGTATAAGCACCCATGCTTGACACCACAGGAATAAATAAAACCAAAAATGAGGTTCCTACTCATTCCCCAAACTTTAGCAATTTTGGTGGTGGTGGTGGTGGTGGTTCCACGTCTTTCCACAGAAATCCAACAAACTGCCAATTTAGCCAAAACATCTAGCTCTAGCGACTTTGCCAAACTGGTGTGAGTTGACTCAATGACTGAGTGGATTTCCTTTTTGGGTTTTACTTCACTCAATATTGGTCTACACTAAGCTCTTTAGGAAGACAGGGTTGAGAGAGGAACAAGTGTTAATGGGATGTAGATCCTCTGAGGCTGAAAGGAATGTCCTTTGTCTCTAAACAATGCCCAGCCGCTCAGGAACACTCTCTTCCAGTCTTCACCCGACCATCTCATTAAAGGCTAAACTCTCCAGTTCGGGTCTATATGGCTAGGAAAGAGGAGCTTTGGGGAAAGCTCTGTCAGAATATACCTGCTTTCTGCAGGGGGCGGGACGACCCCCACAAACAACTCAGCTGGAGAACAATTGTTACATGTGACAATACTGAAGTTTGTACACAGACATGTGAAATTGCTGGCCTGAAGTCACATAACCACTAACTAACGATAATAGCAATTAATGTTTACTGTGTGCTAAAAGTTTCACATACATTATCTCCTTTTATTCCCAAAGCAACCCCCTATACACACACACACCTCCTTTTTGGTTTTGGTTTTACTTTTTAAATTTTACTATTAAATTTTAAATATGTTTTTTTTTTAAATTTACTCCACTAGAGAGGGAACCTAGAACCTCCTGCATCCAAGGTAACTGATCAATGGGTGAGTCACATCTCTATAGAGATTGTAGGTTGTTTCACCAAAAGTATTAGGGCATTTCCTACAGAGTGGTGGAAGTTCGAGTCCTGGGAACATGGAATAACCATGGAATCCAGTAAGTCTTGAGAAAGAAGCTAAAGGAGAAAATGTCAGCACCAGATGGCACGGAAGCAAAGAAGAAGGAGAGCTAAAACCAACAAGCTAAAACCAAAAACGCTTGCTATTTCAACTGTGCCTAACGTACCAGGAAGTACAGCAAGGATCCACTGGCTTAGTGAGGGAATGCTTCTCTAGGCCTCTCCTATCCACTTCCCCTTCCACCCAGTATCCTCCTACTCCTTCATCTGCTAGAGACAACTGCCCATAGGTAATTAATTAGCTGTCCCAGCACCCAACTCTCCTGCAGTACTTTGGTTCTGTTTATTTGTTTTGGCAATAGCATCTCATTAGGCACGCCATACTCGCCTCAAACTCTGGAATTTCTTCCCTCAGCCTCTTAAGTGTTGTCTTGGGATTACCAGTTTGGGACACTTATTCTCCACCTTTCATGCAGGGCTTTATTCACCAATTTCCACTGTGTGATTCTACGATGCAAATACTAGTGCTTTTTCAAAACAGGGTTTCTCTGTGTCTCAGAACCATTGTCTTTTCTACCACTCCAAACCCAACCATCTTTTCAAACCACTGGTAAGCCAAGTCCTTTCTGGATTAAGTCTGAAGCCATTCTCCACTCCTATTCGATACACTTACTACCTACCACAAACACGCCACCCTCCCACCCTCAATGCCAGTTTTGGGCTTCTCCTTCTATCCTTGCACACCAGTTGTCTTCATCATCAGATCAACCCCTTGAAGAATCGAAGTTCATTGCTCTTGCTTAATCATGCCTGACAAGAAAGTCCAATTCACTAATTCTGTAAACATCTAAGTCAAGCGCTCTTTGATGGGCTCAATGGTGCATCAGACCTGAGTAACGGGTGGAGTACAAGCAAAGTTGTTTCAAGTTGCATAGCGAGAAAGGTCAAGGAAAGAGATGGGGGTTCATCAGGTGAAGGGAAGGATTTTCATTACACTTCCTTTGCTTCAAATTTGGTTTTTGAGCTGAACACACGAAGCCTAATTCATTTCCATGATAGTAGGCTAGACTTGAGAGGGAAGAACTGCTGACAGAAAAGCAGGCGAATTGTACTGACTGGTTTTGTGTGTAATGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTCTCTGTGTGTGTGTGTGAACTTGACACAAGCTGAAAGTTATCACAGAGCCTCACTTGGGGAAAGCCTCCGTGAGATCCAGCTGTAAAGCATTTTCTCAATTAGTGGTGAAGGAGGGCCTATGTGGCTGGTGCCATCCCTCGCCTGGTAGTCTTGAGTTCTCTAAGAGAGCAAGCTGAGCAAGCCACGGGAACCAAGCCACTAAGTAACATCCTTCCAAGACCTCTGCATCAGCTCCTGCTTCCTCACCTGCTTGAGTTCCAGTCCTGACTTCCTTTGGTAATGAACAGCAGTGTGTAAGTGGACAGTGAATAATCCTTTTCTTTCCCAACTTGCTTTTTGGACATGATGTTTTGTGCAGGATATAAACCCTGACTAAGACAACAATCAAAGTGTCTAGTCAAACTGAGTTACTCGACCGGTAGGTAGCTTTGTTTTGCTTGCTTGATGTCTGGACGCCTCTCTTAGCTGGGTATGGCTGAACAAATGAAAAAAGAATATGTTCCCCCTACTTAGGTAAGTATTCTTCCAGGTGGTGATGTCACTGGCCAAGCTGTTCTCCCTTGGCTTCCCACAGCTCTCTTCCTTTACCACATACCATGTCCATCTTTACACAAATGACTCTAAACCTCTTCTCTCCACAGACACCTTCAATCCACATGAGATAAAGCCTCCACATTTTGTAGCTCTGGCTGACCTGGAACTCACTATGCACACCAGCCTTGCATTGAACTTTCAGAGATCTGCCTATATCTTTCTTAGGAGTGCTAGGACTAAACGCATGCACCACATTTAGTCCTGCThAACTTCTTTTTTTGTTTTTTTGGTTTTTTCGAGACAGCGTTTCTCTGTGTACCCCTGGCTGTCCTGGAACTCACTCTGTAGACCAGGCTGGCCTCAAACTTAGAAATCCACCTGTCTCTGCCTCCCAAGTGCTGAGATTAAAGATGTCTGGTACTACTGCTTAGACTGACACACAAAATATTGTTGAAGCCAGTGAGATAAAGCTCACCTTCAATCTCACACGTAGGCCAGGCAGACTTTTGTGAGTTCTGGGCCAGCCAGAGCTTCATATGAAAAGTAATAATAATGATAATAATAATAATAATTTTAATAAACAAATGGGTGTATGAAAGAGTAAATCTGCACATATTTCTGGCATCTGTTTTAAQATTCTACTTCCTTAGGCTGTCAGTCATTCTCACCCCATTCAACCCTTTCCTCTGCACTGTGATTGACAAATCTTCTCTCCCTCTGGTGACTACCTAATTCATCCCACACAGCATCAGCCTTGGCAACAACTTCTCTATGCAGGGACTGTAAGTTCCAGACAACAGAAACTCTGTTCCAATTCACAAAATCAACTAGGAAAGGAGAAGAGACAGAGGACAGAGGAAAGGAAGGAAGAAGGGAGAAAAGGAGGGAGGGAGGGAGGGAGGGAGGGAAAATGTCAATTTATGCAACTCTTTCATGATTCATCCAAGGATCCTCTCTGATTCTTTTTTGGTTGTTGTTGTTTTTGTTTTTTCGAGACAGCGTTTCTCTGTATAGCCCTGACTGTCCTGGAACTCACTTTGTAGACCAGGCTGGCCTCGAACTCAGAAACCCACCTGCCTCTGCCTCCCAAGTGCTGGGATTAAAGATGTGTGCCACCACGCCCAGCTAAACCTCTTCCTTCTAGCCAGAAGAACACAGCAGAAAGAACTATGATCAGTCTTCTGGAACCATGTGCTTACCCTTAAACCAGACAATTCACTTGGTTCCCAGGACCACACTCCTCCTGCAAAAGTTGGAACCCTGTGATTCTCAGCTTCTGAGGCAAAGGGAAGACCTATCCAAGATAAAAAACCAACAACAACAAAAAAGTCAATATAAGAAAAGAAAAAAATGTTCTCTAGATACATTCTGGGTAGTGATGGTTCTCACTGTTCAGAGATATAAGAAAAGAGCAGATGCTTAAAACCCTGACTCTTGAGAACAACTTTTGGTAAGAGAGACTCCTTTTTTTAAAATTTTATTTATTTATTTATTTACTTACTTATTATATGGTAAGTACACTGGTAGCTGTCTTCAGACACTCCAGAAGAGAGTATCAGATCTCATTACAGATGGTTGTGACCCACCATGTGGTTGCTGGGATTTGAACTCAGGATCTTTGGAAGAACAGTCAGTGCTCTTAACCACTGAGCTATCTTACCCAGCCCCCCACCCACCCCCCCAACCCCGTTAAGAGAGATTCGAATGGTCCATCTTAGAGGTATTGAAATTGAGTCTGAAGTGGGAGGCCTAGGGGCTGTTTTGAGCCAACTCAGCCCAGGTGATTTGCAGTGAGGTGGGAATTCCAAGGGCAAACAAGGATCAGCAAAAGCTATACCCCTCTACCACAGATTTGGAGAGAATTCAGATGGGAGGCCTGTTCCAGCCATTGCTCAGTAAGTAACCAACAGTCTAGCTACCTCTTCATCTCCCTCCTTCTACCACACCATTAAGTCCCTCCACCCCATCAGCCTCAATGATTCTTTCTTTTTTTTTTTTTAATTAGGTATTTTCCTCATTTACATTTCCAATGCTATCCCAAAAGTCCCCCATACCCTCCCCCTCCACTCCAACTTTTTGGCCCTGTTGTTCCCCGCCTCAATGCTTCTTCGCTCTATCCATGTCTCCTTGCCCACTTTGCTTCTGCCAACCGATATTCTTTACCTGGGACTCTCTAGCAGATGCCAACTGCCTGTCTCTCATCTGGTTTCCTCAAACCTACAAAAATGCTCTCCCAAATAAGCCCGATCAGTTTACTCCCTGGCGTAGGAGAACTTCATGATTCATCTGCTCTGCTTCTAAAATACAGATCTGTGGGCCTGGTAGTGCAGATGTTAATCCCAACTACTCTACTTCCCAGCCCTAGGGAATGGACTCCATGTTCAAGGTCTGCCTGGACAGCAAGATGAGTGCTGGGGAAGCCACAGAAAATGAGTAAAACTTTCTGAAAAGTAAAGCATTATAAAAACAAACAAACAAAGGTCCAGACAACTGGGGAGATGATTGGCTGGTTAAGAGTACTTGCTCTTCTCCATGGGACCCAAGTTCAGTTCCTAGAAGCCGAGTAGCTTGCACCTTCAATTATGGCCCCCTCTTCTGTTTTCTCAGGACCAGGTCCACACAGTGCATATAACATACATGTAAGCAAAATACTCACACACATAAAATTAAAAATAAATAAATCTTTCAGGCAAAACTGACCTGGGATATAGCTCAAGGATAGACGATTTGCATGGCATGCTAGCAGCCCTGACTTCCATCTACAGTCCAGAAAGACAAGTAAATCAGAAATGCCTTTGACCCACTGAAGAGATGATTCAGAGGTTAAGAGCACTGGCTGCTCTTCCAGAAGACCTGGGTTCAATTCCTACTACCTGCATGAGAGCTGACTCCAGTTCCAGGGAATCTGACCCTATCACTCAGACACTGTTCTTGTCATCTGCACACGCGATGATCACACACATATCATTTCACATGTGGGGATACTGACAATCAGAGTCAGCAGGTAACTGTCTCAACTTCAACTAAGCAGGGCAGTTTGTTAGCAGGGATGGAATCTCGATTCTTATTGCCCCCCAGCTTCTTCACTTCCTGCTGCCTCTCTACAACCACACCATATTGAAATTACCTTCTTCCCTCTCTTGCTTCCGCACTGAAACTGGGGCTGAATCTAGCTGGCTACCTGACCTGATTCTCTCCTATCAGATGGATGACTTGCTGTCCTCCTGGGTCATCTCCCGTGTTTAGCAAGACAGGGTATAGAGTTTTAAATGAGTGTAGGCAGAGTAACATGAATCATCACACTTTTACCCAGAGTGCATGAATCATCAGACTTTCCTACGCCAGGGAGTAACTGAGCACGCATATTTTGGAGACCACTTCTCTACTCCTAGGGTCAGAAGAGCCTGCAGATGATCTACTCAAAGCAATTTTATCTGCCATTCTGTTCAGTAGTGAGGCAAGGATCATGTTACCTGCAACGGGGCCAATCTTTGCCTCTGTTTTTGAAGTCTCTGGAGAAGTAGCCGTCTTCCTGCGCTGGGGATATGATTAAGCAGTAGAACATCCACATAATTTCATGAGGCTAACATACAGCTCTTCAGAGATCAGCCTACTTATTTATGACACAATTGTTTTAAGACATCAGGTATTCTAGGAGATAAGATTCCTTCTCTTGCTTTCCTGGTACCCAGAATGATCTCCTAAACCACAAGTAATTGGCACAGAGATGGATCTTCCAAACTGACCCACATCTACACAGATCTTATCTTCATACCCAAGAACTCCCCAGTCAATGGATATTTGGGGCATTTCCTATCCACACACACGTCAGTCTGGAATAACCGTACTCCAGCACTTAGTAGAAAGGATGTATACTGAACCAGTATTTACAAATAATTAACCAGATTATTTTCAGGGCACAAATTAGTGGAGCAAGGATTGCAGAGTTACATCAACATCTGATAGCATTGCGGTTCAGCGAAAGTTCCCAGCCAGGGTACAGACGATGGTGATGAAGAAGCATGCTCAATATCTTCAGGCGCTGCTATGAGAAAAQAATGAAACTCTCTAGGGGAACTGAAAGCATACAAGGATGTAAAGAATAGGAAGACCAAAAGGACTTCAACCCTTGGATGAGACACAGGGTGATCCAATACCCGGTGACCTGCAGGGACTCACGCCCACTGGTTATGATCGCAACCTACCCACAGTCGTGAGTATGATGCAGTGGGAACTCACAGTACTGAAAACCAACACACTTAACTTGCCTGTGCTGCTGTGAACGTCCATTCAATGAGGGTCACCAAGCTCAAATAAGATAATCGCAAATACTGAGTGGTTCTGACACGAATCCAACCATCAAAAAAAAACTCCTGACACTTGCAGAATGTTTATGTTTCTAATGCTGGGCTAAGTACTTCACCTGGATTATTTCACCAATTCCTCCTCCTCCTCTCCCTGTTCTCCCTTCTCCTCCTCTTCTTCCTGTTCTTCCTCCTCCTCTTCCTCTTCTTCCAAAGATTCATGTGTATCAAGGTATTCTCAA MOUSE SEQUENCE - mRna (SEQ ID NO: 20)GATTGGGGTACGCCCTGCGCCACGTTTCCGCACCAACCAGAGCTGGATAACTCTAGACTTGCTTCCCTTGCTGTGCCCCCTCCACCACACAGCCACGACGATGCCCCTCAACGTGAACTTCACCAACAGGAACTATGACCTCGACTACGACTCCGTACAGCCCTATTTCATCTGCGACGAGCAACAGAATTTCTATCACCACCAACAGCACACCGAGCTGCAGCCGCCCGCGCCCACTCACCATATCTCGAAGAGATTCCACCTCCTTCCCACCCCGCCCCTGTCCCCCACCCGCCGCTCCGGGCTCTCCTCTCCATCCTATGTTGCGGTCGCTACCTCCTTCTCCCCAACGCAAGACCATGACGCCGGCCGTCCCAACTTCTCCACCGCCGATCAGCTGGACATGATCACCGACTTACTTGGAGGAGACATGGTGAACCAGAGCTTCATCTGCGATCCTGACGACGAGACCTTCATCAAGAACATCATCATCCACGACTCTATCTGCAGCGGTTTCTCAGCCGCTGCCAAGCTGGTCTCGGAGAAGCTCGCCTCCTACCACGCTGCGCGCAAAGACAGCACCAGCCTGAGCCCCGCCCGCGGGCACAGCGTCTGCTCCACCTCCACCCTGTACCTGCAGCACCTCACCGCCGCCGCGTCCGAGTCCATTCACCCCTCAGTCCTCTTTCCCTACCCGCTCAACGACACCACCTCGCCCAAATCCTGTACCTCGTCCGATTCCACGGCCTTCTCTCCTTCCTCCGACTCGCTGCTGTCCTCCGAGTCCTCCCCACGGGCCAGCCCTGAGCCCCTAGTCCTCCATGACGAGACACCGCCCACCACCAGCAGCGACTCTGAAGAAGACCAAGAAGATCACAAACAAATTGATGTGCTGTCTOTGGAGAAGAGGCAAACCCCTSCCAAGAGGTCGGAGTCCGOCTCATCTCCATCCCGAGGCCACAGCAAACCTCCGCACAGCCCACTGGTCCTCAAGAGGTGCCACGTCTCCACTCACCAGCACAACTACCCGCACCCCCCTCCACAAGGAAGGACTATCCAGCTGCCAAAGAGGGCCAAGTTGGACAGTCGCAGGGTCCTGAAGCAGATCAGCAACAACCGCAAGTGCTCCAGCCCCAGGTCCTCAGACACGGAGGAAAACGACAAGAGGCGGACACACAACGTCTTGGAACGTCAGAGGAGGAACGAGCTGAAGCGCAGCTTTTTTGCCCTGCGTGACCAGATCCCTGAATTGGAAAACAACGAAAAGGCCCCCAAGGTAGTGATCCTCAAAAAAGCCACCGCCTACATCCTGTCCATTCAAGCAGACGAGCACAAGCTCACCTCTGAAAAGGACTTATTGAGGAAACGACGAGAACAGTTGAAACACAAACTCGAACAGCTTCGAAACTCTGGTGCATAAACTGACCTAACTCGAGGAGGAGCTGGAATCTCTCGTGAGAGTAAGGAGAACGGTTCCTTCTGACAGAACTGATGCGCTGGAATTAAAATGCATGCTCAAAGCCTAACCTCAACAACCTTGGCTGGGGCTTTGGGACTGTAAGCTTCAGCCATAATTTTAACTGCCTCAAACTTAAATAGATAAAAGAACTTTTTTTTATGCTTCCCATCTTTTTTCTTTTTCCTTTTAACAGATTTGTATTTAATTGTTTTTTTAAAAAAATCTTAAAATCTATCCAATTTTCCCATGTAAATAGGGCCTTGAAATGTAAATAACTTTAATAAAACGTTTATAACAGTTAAAAAMOUSE SEQUENCE - CODING (SEQ ID NO: 21)ATGCCCCTCAACGTGAACTTCACCAACAGGAACTATGACCTCGACTACGACTCCGTACAGCCCTATTTCATCTGCGACGAGGAAGAGAATTTCTATCACCAGCAACAGCAGAGCGAGCTGCAGCCGCCCGCGCCCAGTGAGGATATCTGGAAGAAATTCGAGCTGCTTCCCACCCCGCCCCTGTCCCCGAGCCGCCGCTCCGGGCTCTGCTCTCCATCCTATGTTGCGGTCGCTACGTCCTTCTCCCCAAGGGAAGACGATGACGGCGGCGGTGGCAACTTCTCCACCGCCGATCAGCTGGAGATGATGACCGAGTTACTTGGAGGAGACATGGTGAACCAGAGCTTCATCTGCGATCCTGACGACGAGACCTTCATCAAGAACATCATCATCCAGGACTGTATGTGGAGCGGTTTCTCAGCCGCTGCCAAGCTGGTCTCGGAGAAGCTGGCCTCCTACCAGGCTGCGCGCAAAGACAGCACCAGCCTGAGCCCCGCCCGCGGGCACAGCGTCTGCTCCACCTCCAGCCTGTACCTGCAGGACCTCACCGCCGCCGCGTCCGAGTGCATTGACCCCTCAGTGGTCTTTCCCTACCCGCTCAACGACAGCAGCTCGCCCAAATCCTGTACCTCGTCCGATTCCACGGCCTTCTCTCCTTCCTCGGACTCGCTGCTGTCCTCCGAGTCCTCCCCACGGGCCAGCCCTGAGCCCCTAGTGCTGCATGAGGAGACACCGCCCACCACCAGCAGCGACTCTGAAGAAGAGCAAGAAGATGAGGAAGAAATTGATGTGGTGTCTGTGGAGAAGAGGCAAACCCCTGCCAAGAGGTCGCAGTCGGGCTCATCTCCATCCCGAGGCCACAGCAAACCTCCGCACAGCCCACTGGTCCTCAAGAGGTGCCACGTCTCCACTCACCAGCACAACTACGCCGCACCCCCCTCCACAAGGAAGGACTATCCAGCTGCCAAGAGGGCCAAGTTGGACAGTGGCAGGGTCCTGAAGCAGATCAGCAACAACCGCAAGTGCTCCAGCCCCAGGTCCTCAGACACGGAGGAAAACGACAAGAGGCGGACACACAACGTCTTGGAACGTCAGAGGAGGAACGAGCTGAAGCGCAGCTTTTTTGCCCTGCGTGACCAGATCCCTGAATTGGAAAACAACGAAAAGGCCCCCAAGGTAGTGATCCTCAAAAAAGCCACCGCCTACATCCTGTCCATTCAAGCAGACGAGCACAAGCTCACCTCTGAAAAGGACTTATTGAGGAAACGACGAGAACAGTTGAAACACAAACTCGAACAGCTTCGAAACTCTGGTGCATAAHUMAN SEQUENCE - GENOMIC (SEQ ID NO: 22)ACTCCCACCACACCTATTCAACATAGTATTGGATTCCCTGGCCAGAACAATTAGGCATGAGAGAGAAACAACAGGCATCCAAACAAGAAGAGAGAAGGTCAAATTATCCCTGTTTGCAGACAATATGATTCTGCATCTAGAAAACTCCATAGCCTCTGCCCCGAAACTCCTTGAGTTGATAATCAACTTCAGCAAAGTTTCAGGATACAAGATCAATGTACAAAAATTAGTAGCACTCCTATACACTAACATCACCCAAGCCAAGAGGCAAATCAGGAACACAATCCCATTCACAATTGCCACAAAATAATAAAAAGCTTAGGAATACAGTTAACTAGCGAGGTGAAAGATCTCTACTATGAGAATTAAAAACACTCTTCAAAGAAATCAGAGATGACCCAAAACAATTGGAAGAACATTCCATGTTCATGCAAGGGAAGAATCAATATTGGTAAACTGGCCATACACCTCAAAACAATTTACAGATTCAATTTTATTCCTATCAAACTACCAATGACATTCTACACAGAAATGGAAATAACTACTCAAAAATTCATATGGAGCTAATAAAAGAGTCTAAATACACAAGGCAATCCTAGGCAAAAAGAGCAAAGCTGAAGGAATCACATTGACCAACTTCAAATTGTACTACAAGGATGTAGTAATCAAAACAGCATGGAACTGATACCAAAACAGACACATAGACCAATGGAACAAAATAGTGAGCACAGAAATAAAGCCACATACCTACAACCATTGGATCTTTGACAAATCTGACAGAAACAAGCAAGAGGGAAAAGACTCCCTATTAAATTAATGGTGCTGTGATTACTGGTTAGCCATATGAAGAAAACTGAAACTAGACTTATGCCATATATAAAATCCATATGCCGGAAAGCTGAGGCAGGAGAATCACTTGAACCCGGGAGGTGGAGGTTGCAGTGAGCCGAGATCACACTACTGCACTGCAGCCTAGCGACAGAGTGAGACTCCGTTGCAAAAATAAATAAATAAATAAATAAATAAATAAATAAATAAATATCAACTCAAGGTGGATTAAAGACCAAAATGTAAAACTCTAAAACTATAAAAACCCTGGAAGATACCCTAGGAAATACCATTTTGGACATAGGAGCTGACAACGATTTTTTGAAAAAAACACCAAAAGCAAAAGTTGACAAATAAGACCTAATTAAACTAAAGAACTTCTGCACAGCAAAAGAAACTATCAACAGAGTAAATAGGCAACCTGCAGAATGGAGGAAAATATTGACAAACTATATATGTGACAAAGGCCTAATATACAAAATCTACGAGGAACTTAAACATACAAGGAAAAATCAAACAACCCACCTCACTAAAAAGTGGGAAAAGGACATAAACCGACACGTTTCAAAAGAAGACATACAAGCATATACATACAAGCCAACAAGCATATGAAAAAATGCTCATCATGACTAATCATTAGAGAAATGCAAATCAAAGCAGCAATAAGATACCATCTCACACTAGTCAGAATAGCTATTATTAAAAAGTTAAAAAATCACAGATGCTGGTGAGGTTGTGGACAAAAGGGAACGCTTATACACTGCTGGTGGGAGTGTAAATTAGTTCAACCATTGTGGAAAGCAGTGTGGTGATTCCTCAAGTAATTAAAAACAGAACTACCATTTGACCCAGCAATCCCACTACTGGATATAAACCCAAATAAATATAAATCTTTCCACCACGAAAACACATGCAACCATGTGTTCATTGTAGCTCTATTCACAATAGCAAAGGCATGAAATCAGCCTAAATGCTCAACTACTGCAGACTGGATAAAGAAAATGTGGTACATACACACGATGCAATACTAAGCATCCATTAAAAAAAAAAAAGAAATCATGTCCTTTTCAGGAACATGAATGGAATCAGAGGCCATTATCCTTAGCAAAACTACCACAGGAACAGAAACCAAACCTATGTTTTCACTTATAATTGGGAGCTAAATAATGATAACCCATGGGCAGAAAGAGGCCTCACACTGTGAGGCCTGCGTGAAGGAGGAGGATGGGAGGAGAAAGAAGTCCAGGGGAAAAAAACTTCGGGTACTGTGCTTAGTACCCAGACAGCAAAATAATCTCTACACATTGATGGGACGTATCTCAAAATAATAAGAGCTATCTATGACAAACACACAGCCAATATCATACTGAATGGGCAAAAACTGGAAGCATTCCCTTTGAAAACTGGCACAAGACAAGGATGCCTTCTCTCACCACTCCTATTCAACATAGTGTTGGAAGTTCTGGCCAGGGCAATCAGGCAGGAGAAAGAAATAAAGGGTATTCAATTAGGAAAAGAGGAAGTCAAATTGTCCTTGTTTGCAGATGACATGATTGTATATTTAGAAAACCCCATCGTCTCAGCCCCAAATATCCTTAAGCTGATAAGCAACTTCAGCAAAGTCTCAGGATACAAAATCAATGTGCAAAAATCGCAAGCATTCTTATACAACAATAACAGACAGAGAGCCAAATCCTGAGTGAACTCCCATTCACAATTGCTTCAAAGACAATAAAATACCTAGGAATCCAACTTACAAGGGATGTGAAGGACCTCTTCAAGGAGAACTACAAAACACTGTTCAATGAAATAAAAGAGGACACAAACAAATGGAAGAACATTCCATGCTCGTGAATAGGAAGAATCAATATCGTGAAAACGCCCATATTGCCCAAGGTAATTTATAGATTCAATGCCATCCCCATCAAGCTACCAATGACTTTCTTCACGAATTGGAAAATAACTACTTTAAAGTTCATATGGAACCAAAAGAGAGCCCGCATTGCCAAGTCAATCCTAAGCCAAAAGAACAAACCTGGACGCATCACGCTACCTCACTTCAAACTATACTACAAGGCTACAGTAACCAAAACAGCATGCTACTGGTACCAAAACAGAQATATAGACCAAAGGAAGACAACAGACCCCTCACAAATAATGCTGCATATCTACAACCATCTTACCTTTGACAAACCTGACAAAACCAAGAAATGGGGAAAGGATTCCCTATTTAATAAATGGTGTTGGAAAACTGGCTAGCCATATGTACAAAGCTGAAACTGCCTCCCTTCCTTACACCTTATACAAAAATTAATTCAAGATGGATTAAAGACTTAAATGTTAGACCTCAAACCATAAAAACCCTAGAAGAAAACCTAGGCAATACCACTCAGGACATAGGCATGAGCAAGGACTTCATGTCAAAAACACCAAAAGCAATGGCGACAAAAGCCAAAATTGACAAATGGGATCTAATTAAACTAAACACCTTCTGCACAGCAAAAGAAACTACCATCACACTCAACAGGCAACCTAAAGAATGCCACAAAATTTTTGCAATCTACTCATCTCACAAACCCCTAATATCCAGAATCTACAATGAACTCAAACAAATTTACAACAAAAAAACAAACAACCCCATCAAAAAGTGGGTGAAGGATATGAACAGACACTTCTCAGAAGAAGATATTTATGCAGCCAAAAGACACATCAAAAAATGCTCATCATCACTGCCCATCACAGAAATGCAAATCAAAACCACAATGACATACCATTTCACACCACTTACAATGGTGATCATTAAAATGTCAGAAAACAACACGTGCTGCAGAGGATGTGGAGAAACAGGAACACTTTTACCCTCTTCCTGGCACTGCAAACAAGTTCAACCATTGTGGAAGTCAGTGTGGCGATTCCTCAGGGATCTAGAACTAGAAATACCATTTGACCCACCCATCCCATTACTGGGTATATACCCAAAAGATTCTAAGTCATCCTGCTATAAAGACATGTGCGCACCTATGTTTATTCCGGCACTATTCACAATAGCAAACACTTGGAACCAACTGAAATGTCCATCAATGATAGACTGGATTAAGAAAATGTQGCACATATACACCATGGAATACTATGCAGCCATAAAAAATGATGACTTCATGTCCTTTGTACCGACATGGATGAAGCTGGAAACCATCATTCTCAGCACACTATCTCAACGACAAAAAACCATACACCACATGTTCTCACTCATAGGTGAGAATTAAACAATCAGAACAGATGGACACAGGAACCGAAACATCACACACCGCCCCCTCTTGTGGGGTAGGGGCAGGGGGGATGCATACGATTAGGAGATATATCTAATATTAAATGACCAATTAATGAGTGCGGCACACCAACATGGCACATGTATACATATGTAACAAACCTGCACATTCTGCACATATACCCTAAAACTTAAAGTATAATAAAAAAAATCTGTACACTAAAACTCCAACTCATGAGTTTACCCATATAAAAAACCTGAACCTAAAATAAAAGTTAAAATATTCAAATATAAATAAGTAAATAAATAAAATGACAAACCCATGGCTAACATCATGTTGAATAACGAAAAGTTGAATGCTTTTTTTTCTAAAATCCAGGAGAAGACAAGGATGTCCATTCTCTCTTCTACTCAACATGGTACTGGGAGTCTTAGGTAGAACAATTACACAAGAGAATGAAATAAACGTCATTCAAATTGGACAGGAGGAAGTCCTTTTCTGCAGTAACATCATCTTATACCTATAAAACCCTATAGACTCAACCAAAGAAAAATAACTGCTAGTATTGATAAATGAATTCAGTAAAACTTCAAGTTACAAATTTAATGTACAATAATTAGTAGTGTTTCTACACAGCAACAGCAAACTATCTGAAAAAGAAATCAACAAATCTATCTCTTTTACAATAGCTACAAAAATTTCAAAAAATTTCAAAAAATACCTAGAAATAAATTTAACCAAGGAGGTGAAAGATCTCTACAGTAAAAAATAATAAAATATGGATGAAAGAAATTGAAGAGCATACTAATAAATGTAAAGTTAACCCATGCTCATAGATTTGTAGAGTTAATCTTGTTAAAATGTCCATACTACCCAAACCAATGTACAGATACAATGCAATCTCTATCAAAATACTAAGGACTTTCCTCACAGAAGTAAAATATATATATTTTTTAATATATAAAATGTATATATAAATATAATATATAATAATGAATATTATATATGATTATAATATTATATGATTATATACTATTAATATTATTAATAATTATATTATTATATATATTATATATATTATTATATATTGTATATAAATATATATTATATACTATATTATTATATATTGTATATAAATATATATTATATATACTATATATTTATATACTATATATATAGTGTATATATATATTTATATAGTATATATAATATATACACTATATATTTATATAGTATGTATATATATATACTATATATAATACATAAAATATATATACATATATAGTATATATATGAAATATATATATACTAAATTTGCACAGAACCACATGATTCCAAACAGCCAAAGCAATCTGGAGCACAAAGAACAAAGCTAGATGCATTACACTACCTGGCTTTTAAATTTTCTACAAAGCAATAGTAAACAAAATAGCATAGTACTAACATGAAAACAGATCCATAGACTGATGGAGGAGAATAGAGACCCCAAAAATGAATCCATACAATTATAGCCAACTAGTTTTTGACATATGTACCAAGAAAACACATTCGGCAATGGAAAGTCTCTGCAATAAATGGTGCTGGATAAACTGAATATCCACAAGCAGAAGAAAGAAACTAGGTGCTTCTCTCTCCCAACATATAAAAATCAACTCAAAATGGATTAAAGACTTGAATATAAAACATGAAACTAAGAACATCCTTGAAGAAAACACAGGGCAAACAATTCATGATATTGGTCTGGGAAAGAATTTTTCAAATAAGACCTCAAAAGCACAAACAACCAAAGCTAAAATAGATGAATGGGATAATATCAAGCCAAAAAGCTTTTACATCTTAAAGCAAACAACAGAATCAAGAAATGACCTACAGAATGAAGAAATATTCACATACTATGCATCTGACAAGAGGTTAATATGAAACTATGTAATCAATGCAAGCAACTCAATAGGAAACACACAAATAATCCAATCAAAACTTGGCCAAAGGATTCGAATAGATATTTCTTAAAAGGAGTCACACAAATGGCCAGCAGTAATATGAAAAAAGGCTCAACATCACTAAGAACCAGGGAAATGCAAATCAACACCACACTGAGCTATCCACTCATCCCACTTAGAATAGTTATTATTTAAAAAAATAAAATAAAAAGACAAGAAAATGGCCAGTCATGGTGGCTCATGCCTGTAATCCCAGCATTTTGGAGGCCAAGGAGGGCAGATCACTTAATGCCAGGAGTTCAACAACAGCCTGGCCAACGTGACGAAACCCCATCTCTACTAAAAATACAAAAAATTAGCTGGGCATGGTGGCACATGCCTGTGGTCCCAGCTACTCAGGAGGCTGAGGCACCAGAATTGCTTGAACTGGGGAGGCAGAGGTTGCAGTGAGCTGACTTCGCACCACTGCACTCCAGCCTGGGTGCCACAGCAAGGATCTGCCAAAAAAAAAAAAAAAAAAAATATAAAAAAGACAAGAAATAACATATGCTGGTAAGGATGTGGAGAAAAGTGAACTGTTATACAATGCTATACACTTGGTGTACTACTATATTATCCACCAATCCCACTGCTGGATCCCCCTCCCCCCCAAAAATGAAATCAACATATCAAAGAGTTCAGATCCCCATGTTTATTGCAACACTATTTGCAATAGCCAAAATATGGAATCAACTTAAGTGCTCATCAACACATGAAACAGGAATGAAAATATGGTATATATACACAATGGAATGCTATTCAATCTTTAAAAAAGAATGAAACCCTCAAAAAGTGGGTGAAGGACATGAACAGACACTTCTCAAAAGAAGACATTTATGCAGCCAAAAAACACATCAAAAAATGCTCACCATCACTCGCCATCACAGAAATGCAAATCAAACCACAATGAGATACCATCTCACACCAGTTAGAAAAGGCAATCATTAAAAAGTCAGGAAACAACAGGTGCTGGAGAGGATGTGGAGAAATAGCAACACTTTTACACTGTTCGACCCACTGTAAACTAGTTCAACCATTGTGGAAGTCAGTGTGGCGATTCCTCAGGGATCTAGAACTAGAAATACCATTTGACACAGCCATCCCATTACTGGGTATATACCCAAAGGACTATAAATCATGCTGCTATAAAGACACATGCACACGTATGTTTATTGCGGCACTATTCACAATAGCAAAGACTTGGAACCAACCCAAATGTCCAACAATGATAGACCGGATTAAGAAAATGTGACACATATACACCATGGAGTACTATGCAGCCATAAAAAATGATGAGTTCATCTCTTTGCAGGGACATGGATGAAATTGCAAGTCATCATTCTCAGTAAACTATCGCAAGAACAAAAAACCAAACACCACATGTTCTCACTCATAGGTGGGAATTGAACAATGAGAACACATGGACACAGGAAGGAGAACATCACACTCTGGGGACTGTTGTCGGGTGGGGGGAGGGGGGAGCGATAGCTTTAGGAGATATACCTAATGCTAAATGACAAGTTAATGGGTGCAGCACACCAGCATGGCACATGTATACATATGTAACTAACCTGCACATTGTGCACATGTACCCTAAAACTAAAAGTATAATAATAATAATAAAAAAGTAAAAATGATTAAGGACTATAATAGGATAAGAACTCTAGGAAGATGATAAAGTATGCCCAAAAGAAAGCAATGCTATAATAAAAACAAAATAAAACAAAACAACAACAACAAAAAGAATCAAACCCTGTCATTTGCAACAATGTGGACAAACCTAGAGGACTTTATGTTAAGTGAAATAAACCAAGCACAGAACGAGAACTACCACATGATCTCAGGCATATGTGGCATCTAAAAAAGTTGACCTCAAAGACAGTTTAGTACTGGCTATCGGAAACTGAGGAGAGTACTTCCGAGGGGGAGGGGAACAGGTTGCTCAACAGCTACAAAGTTACACTTATATAGGACAAATAATTTCTGATAATCGACTGCACAGTAGGTTGAGTGTACTCAACAATAATGTATTCTGTACTTTAAAATAGTTACACGAGAGGATTTTGGACGTTCTCACCACCAAGAAATGACAAATGTTTCAGGTGATAGACATATGCTAATTATGCTGATTTGATCATTACACAATATATATGTATCAAAACATCACACTGTATCCCATTAATATGTACAATTATACATCAATTTAAAACAAAATAAAATGTATTTTATAAAAATTTTAAAACTTCAACCAGCAAGTTTGAATCTCCTATTCCCAGTTTTGCTCAGCCCTACAGTGTATACCAACCAGCCTGGCCTGGGGCTGCTGTTAGAGGAAGAAAGAAACATCTGGACTTGGAATCAAACAGATCTGGAAGGAATCCTAAATTTTCCAATAACATCTCTGTATTCCTTTCATCCTGGTCCCTACCCAGGAAGCAGTCTAGACGACATGATCCTTTTCTAAGAACAGCAACATTCAGTAAACAAACTTCCTTACTAATGTGTGTGGATCAAGAGATGGTGAGGAAAGTACAGTCACTGATATTTTTGAATCAATTATCACAACGCCACCATGCTATTGCTCACTAATATTAGATGCCCATGGACAGTAAGATTCATCGATGGTCCGTCTTTATTATTAGGTCATTACTGAGTGGCTTTTGCAATAAAATACACCATTCGCACAATAAAAATATTCTCTAATGCAAAAACATAGCATCCATTGTTTTTAAGGGGCACAATAGTGTGCTTCATCAGACTGGAATAGCAACATTGTAATCTGAAAAAAGCTCAACAGTGGTGAGGCATATTCAAAAGCCCCAAGACGAGAGTCAACAGTCACATCCATCAGAGTTGAGAGGTTGCCACAACTTATGTAATGACCTCTCCACCCCATGAAACACATGTGTCAGCTTTTCTCAGGAGTCACAGATCTGGCATGCAGCAGGAGATTCTGCATTAGATATATAAAGTCAGCCCCAATCATCCCCTTCATTACTTACTCTCATCAGACAATGAGCCCTTGCCATGCCTCTGTATATGAGGAATCCACGCAGTTCAGTAAGTAGTCAAGATTTGTTTCCACATGCGGTCCCAAAGAAGTCTTTAATCTCACAGACTAGTTTTCCAAGTCGCATACCAAAAGGCTGGACCATTCGTAGTGTCCCAAGAATTGGGTTCTCACCATTGAGCACACAAACCAAGTCCTCTTTTTATTTCTGCATAGCTGGTTCAGAGGCTGAACACACACAGGAGCCAGTCAACACCATCAGTTTTCAGCTTAGCCAATCCTTCACTGAGGCAACCCCAGATATTTCGGCAAACCTCTGTAAACACGCTCCAATTGAACTAGTACTGTTGTTTCAAGCAGGAGAATAAAAGGTTAACTTTCCCCCAGACAGACAGTTGCCACTCTTACATATAAACCACACATGCAGAAGAAATTCGAGTTGATGCCATCGCCCACCCACCAACCCACCCCCGCATTTCCGCCCTGAGACTAGGATCCCAGCGCCAGGGACCCAGACCCTCCGATTGATCCCACACAGCCGTGATCCGGAGAGTGCCCCGCGCATCAGACCGAATCTCGGGGCCACTCGACAGCTTGGGCCAGGAACCATCCATCCATTGTCCATCGTGACTCCATGTGGACCAGCTATTTGCCCTGGGAACAGCTGTACACAGCCGGCACCGACTCCCTCCCCACTGCCGCGCCCTGGGGGAACCCGCCCAAGGTGCCCTCCTCCCCAGACTGCCCTCCCAGCCTCCAAGACGGCAATCCAGCGCCCACTGCTCCCTGGACTCTGCGCAAGGCCAAGACTCAGGCCTGCTCCAGATTTGAGAACCCAAACAACTCAGAGGGTGAGGAAATTGACCTTGTCACACCAAAGAAAAGGCAGATTGGGTTTACAGAACTCCATCACCATCATGGTTCGAGTAGACCGTCTGAACCCCTGCATGAAACACTTCCATACCTCCATCCACCACCAACAACACAACTGCGCTGCCCATATTTCTCCACAAAGCTGCTCCCAAGAAGAGGCTCCAGAGAGAGGTCTCCAAGAAGAGGTTCTGGAGGGAGATGCTCCAGCGGAAACGGAACATGAGCAGGATGAGGGGATTGTCACCCCCTCACCTATAGAAAGCAAGCCTGCCCAGTGCTGCCAGTTCTGACACTGAGGATGTGACCAAGAGGAAGGGCCACACCTTCCTGCACCACAAGAGGTGGAATGACCTGCGCGTTCTCAGTTCTTGGCCCTGAGGGACCAGGTACCCACCTTCGCCAGCTCCTCTAAGGTCCCCACGGTAGTGATCCTAAGCAAGGCCTTCCGATACTTCCAAGACCTGGCGTGAACCGAGAAAAACATGTCTATGGAGAAAACGCAGCTCCAACGCCAGCAACAGCAATTGCAGAAATGAATTGCGTACCTCACTGGCTACTAACTGACCAAAAAGCCTGACTGTTCTATCTTACAAAGACACAAGTTTATTTTTTGACCTCCCCTTCCCCTTTAGTAATTTTCACATTTTGGTTATGACGGGACAGTCTTTGCAGTAGGTCCCAGAATGCATTGCAGCCAGTACACACACAATAAGGGCTTGCATTCTTGGAAACCTTGAAACCCAGCTCTTTCTCTCCCCTGACTCATGCTGTCTCTTCTCTGGCGCCTTTGGCTTCTCAGCAGATAGCTGACTGAGGAGATTTGGGGTCTGTTTACCTCACTACCTCCGAAGAAAAGGCTGACAGATACTATGCAACAGGTGGTGTATCTTCTCGGGGACTCCAGCCTGCATGAAATCTCACACTCCGCGTGAGCCTTAGACTAGGAAAGAATCCTCCCTCGTATCTCTGGGGTGATGCTAGAATGCTCCCTCCTATGTCTGGGGTCATGCAAGGACAGCTCGGCCTGGACACCACTCTCGCTGTGGCTTTTTTTTCCAGGACACACACAACCTCTCTTGGGTGATGACAAGCTTGAACATTTGATCAACATGACCATTGCTTCACTGTCAGACACTTTACAGTATCTGAGGAGTTGGAAACCTTTAACGTATATATTGTGATATTAGCTGACACCTCTCCTTCCAGTTTCAATGCTGAGACCCTGAGAACATTTAAAGAGCTTGCACTCTAGGTTCCTTGTCTCAGAGCTCTCTGGGCCTTCTCTGATGAAGGGACCTTTCTGTCCTCATGAGAGACTTTTGTTTCATTTTGCCTTTGTTGTGCAATGGGCTTTACAGCATCCTTTCCCACAGGTTAGAAATGTTTCCCCAAGTTACACGCAAGTGGGGATCCTAGCCTGGGGCCTGAGGAAATCTTGGAGTCCTGGCTCCTGAACTTGTTCCCTGTCCGACTGGCACTTCAGGCCACCCATCTTATAATCTCTTCTCAAGGCAGATGTAAGTCACCTCAGAAGCGAGAACTGTACCGCTTCCTCTTTTCCATGAAGCTCTCATCTCAATCTTTCACTGATGAGTGTGAAATTCTACCGGAACCATGCAAACACGTCCACCTTGGGCATCTCCAAGGAACTTGTGGGCTCTGCAGCATACTTGGCTCCCTACCAGCCTGCCATGAGTCATATTTCTTTTCCAGAAGCTGCACTTGCTTCCTGGTATGTTTTAAAGGAGCCTGCAGGAGCTCTGCTTACCCAATCATGATGGATTTTTGCCCCAGCTGGACTCTGCATGTCCAAGGAGAATCCAGGTACAGCCTCCATTCCGGCAAAGACATCCAGCCCAGCAGTTGTCATGTGGGTAACCTCAGGAACCCCTAACCCTGTCCTGGAAAAAGCACAAGCCCCTCCAGAACTCTGCCCAAAATAGCAGGTGCTTGATGGTTCTGAATTTGGAAAGGGATGGGGGGTGATAAGTACTATCTGTGGCTCTGGAAAACCAGCTGCTACATTCAAATCTATTTTCCATAATGGTTTCTTTCTGAGGTTCCTTCGTGGCCTCAGAGAATCCCAGAGGATGTTTTGAAATAGCCTCTCTACCCTTCGGGAGCATGGTAGTTTACAGGAACCAACTGACTTCTGGAACTGTCTATGGAGGGAGAACACGCCAGGTGTAGGTTACTAATGTCCTACATGAATAGCTTGGTTTTATAAGCTGCTGTTGGGTATTATGTTGGGGCAGTCTTTTTAATATATTGTATTTTTGTACGCATTTTGCAAAGTGGAGTTAACTGTTTTGTAAAAGAAAAAAAAGAAACCCTTGGGTGCTTCTTCTGTTTCAAGGGTCTGATTTATTTGCAAAGGCAAGTTTATCTGAAATTTTGTATTATTGATTGCCCAATTTTAAAATGTTGCCTTCTGGGACATCTTGACAAAAAATATTTCTCAAACATGAAGAAAATAAATATAATAAAAAAGAAATGTCTGTGGGATCAGATGACTCTTCTTGATTTTACCGTTTCCATTTCATAAGCCAACCTTATTGACCCCTTCCTACCTGCTAGTCATTGAGTCTGAGTTGACCAACTCAAAGATGGAAATATCGAGCCAGATGCTAACAAATTCTCCATQAATCGATTGTTCAGTTTTGACAGAATCCCAATTGCAAGCCATTAGCTGCTTTTCAAAAGGGATGTACCCTGTAGCCATATTAGGGAGGCAACAAGTCCAGTTCCCCAAGGGATCTCTCTGGGTGTTGACTGCTTCCCCTTGCCAGGTGCCCCCATCGGCAAAATCATCAGTTACACACATTTGTCCTGTATGTAATATTCAAGGAGTTGATTGAGGTTCTGAGCCTCTTTTTCGGTGGCAGCTTGTATGAACAGACGTCAATTTTTTCCTGTTAGAGGGATCTAATGTTCTGAATTTGCCTGCTTAGTCCCAAGAGATTACTTGGCAAGCAGGCCCCTGTATTTGGGACCATAAATCAGCCACCCTTGCTGACACATATGTAATAACACTGCATTGACGACCCTTGAGACTGAGACTTCTAGCCGGCCAGCTGACACAATTATTATGTATATAGTGAAAATATTGAACATTAGAAGGTAGAGACACTAATGCTAAATCCTGAGCCAACCACTGCTGACAAATCTCATTGGAGTTTGTTCCACTAACACTTCCCTCTACCTCTGTCTCTCTGTGATGGGGATGACTTTATATGAGACCTGTAGAATGAGAAATTACAAGCATATCACCCATCAAATCCTGCCATTTATAAGTAGAAGCAACAAGAACAGTTTATTCAACTTTCCCAAAGGCGTCCCTGTACAAACTCATATTGGCTTCCAAACCCCACTGTGAACCATGCCCAAACCCCAACAATTGCTTTTCTGGACTTTTTTCCCTTAAATGAACTCAGACCTAGAGTTCACTACAGGAATTTCAGGGGTTACAGCAAGAGCTGTTAGGCGATTTCCCTATGTCCAGGCCAGAATGTAGGGATTGCAGGGGAGTCTTGGGATGACGCGAGGGGTGGGGACTGTAAGCCTTTTTTGTAATCCCTCTGGCTCTTTGCCCCACCTTGTATGCTAAATCCTCTCCTGTGTACCTCCATTTGTGCAGAACTGTAAGCGCTCAGGGATTCTTCCATTCTGTCCCTTGATTTCCCCAGCAGCTCTGCTCCACAGTCTTGGTGCTTTCATCTACCTCATACCTATTACCCCTTCCCTCCACTCCCCAGAAAATCAGATAACATAGTGTCATGGGAGATTATATGTAACAGTTCTGTGAACATGTGAGTCCGTCCCTTTCCTGAAGTACCCTACCATGCATATGCCTTTTAGTCTGTCTTGAGGACAGAGAGACTTCTGGCTCACCACTAATCATCTTTCTTCTTATAGCACCTGAAGTGAGAAAAGGAAGAGAACCAGGAGTTAGGAAATGCAGAGAGAGAGAGAGAAAAGACTCTGTCTATACTAGTAAGCAAGGCATGTTTGCATTTGGTTTCCAGTAGCCAGCAGTGTGGTTCAACCAAACAAACTTCAGATGGTTTTTTTTCCACTGAAAACTCTATATCTTCACTGCTGACGCCACTTATTCAGGTTTGGCAAGTCATTGACTCAGCACCATCACATCATCCCTTCTTCCTCCCATGCAGAGGAGAGTGAACAACAACCAAACCATGATTCAAACAGCTTGGTTTAATTCTGCATCCTCCCCCTCAGCTTCATTAATAGGTAGGAGAGTGAGTGGGGAAGGGCCTTTAATGCACTTAGTGCCAATCCATTCGGCAAAAAGCATTTGCTCTCCAATCCCGAGGAGTCTTCTCATATCCCCTAACCAGGCCAGTGAAGCACCCTTGTTTTATCACTTTCCAGAATGCTATGTTTCATCTTCATTACCAAAATTGGCAACAAATGTGAAGAGTTTGAGACTGTACCCTACTTGCAAGCTCACAAACTAGCATACCTCAGTTTCACAGATGTTGGCAGAATATATGAGATTCTTGGGTCAGAGTTTGTTTTGCTTCATGTTTGCATTAATTCCCCTTCCCCTCTCCCCCAAATCACACAGGAGAAATGAGGAGCAGCCAGTCAAATGTTGACATACAAGTATTCTTCAAACTATAGTTAGAGACAAAAGCTGTTACAATAAATGTAGAAAGGCCATGCACAATTATCTCAACAATATCTGACCATTGTTTCTCCACTATCTTGGCTTCTGACAAAGTTTGCCATTAAGTATGTCTGTTGATTTTCTGGATATCAGGGCTGAGCAAGGAAAAAGTCATGACCATTAGATCGCAGTAGCACACAACATGCTTTATTTGGTTGGCCCTTTGAAAGGTTTCAGGAGAGTGGAACTTCCCTCACAGCAGGAGACCTTCCAGAGGCAGCAGCAAGACCCCACCACCCAGAAQAGGAAGAGTTCAAGGCAACTTCCAAAGGAGAGAAGAATTGGACAGGAGGCTCATGTGTCTATGGGATGTTACTCAGCAGCCAGGTGTGGAGTCTCTCTCTCAGAGAGTTCCCATGGGCATCAGAGGCTTCGGGCTTTTGTCCAGCCCCAGAGTATGTCCTATCTACGGCTACCACATGGTGTGTCTGGTTTTACAGAGCCTCCAATGTCGGTGGGTTCTAAAGGGCCAAAAATGTGCTTACTGGGGGCCATATTTAAAGCAATTGGGTGTGTAAACATTTCATTTTAGTTCCAATGAGCTTTGAGCTAATCGTCTTACCTGTCTCTGAATATAGGGAACAAGATACAAGGCACCATCTAAACATATTAATCCACTTATTTAACAGTCCATCCCTTGGCCCCATGTTGTTTTACAATCTAAGTTGTATCCTATTTCATGGAGTCTCAGTTGGGAGCCAGCCATGAAGCATCCTCAAGACCCAGAATGCTATAACGCTACAAATTAGCATTTTAAAAGCCAGTTCTCACCCAATCTGCCCACTTGGGCAGCCAGTAGAATAAATTTGAAAGGAGACAATTTTGTTTTGACCAGTCCGTTTACTCAATAGACTGGCATTTATATCCCCTTTGCTACATGACCCCACCTATCTGTAAAACTTGGTGTTATCTACGCACATGCAGGAAGATAATTTTAGCAAGCACACAGCCCCTCTCCCCTCTCACCCCTCCAGCACCCTGACCTAGGGCTATGCAGTTATCTCACACCATCCCCACTAAAGTACAGTCAGATTCACCAAAGAGTTTCAGTCCTTGGGCTGTTTATCTAATTTCTCTGCGTAATTCCTGCAACATGCCTATCTGTTTCTCTTAATTGTGGTGTGCTGTTCCACACATATCCTGTTCCTACTGCCTCCAAAATTAGTGATCCTAGGGAAGTTAGTACCATGAGGAACTATTTGGAAAGCTCATTTGTGACATTGGGGAGTCACATCTAGTGTGGTTTGGTGCCCGAAAGTACTTGACGCACCCGCTTCCACTGTTGAATAAAATTCTACTCGAATTTTGCACCAATCCCAAGTGCAGCAAATATTCTTCACGGTTGGATGAGGAGAACATTGTGATAGGGAAGCCATCTGATTCCTTTACAGGACCTCCACCCTCCCTCTGCTCCCTCTATTCTCTGTCTTCCACTGAAGGGAAGTTCACATGGCTTTGTGAAGTTCCACAAGTTCCAGGTTCTGTTAATAGGAGCAGAAAATGGTATAGTCAAACAAGCTTGTCTTATCCACCTTGCATTCAGCACCTGGGTTAACTAAATTTGTCGTGGGCTCAGCCCACCATTGTCTATACATTTATGTGACATAAGCCTCTGGATAAGGTTGTTGAATGTCAATGGTTACCGGAATCGGCTCATCTAAATAAGTGAGCTATATGATGCAGCGTTGCCAGGAAAGAAGTATTACACTATGTTTTCTAAAATCACCTTCGCACAACCAAACCCTCCATTAGGTTAGATTTACCATCTTATATGTTGCTGTGGCTAAGCCTATAGGCACGTTTCCTGTAGTCGGCAATTGCATGTTCCTCCTTGCTGTGACTGTTGTGTGTTGTGCTTCAGTTTCCTGTTGATTGCCAATAATAAATAGCATTGATGTGTTCCCATGAGTGTGGGATAGGTTTTGCAGGTCTTATTGCCAGTCCAAGAAGAACGTTGTTAGTCTACCCACACACCAAATTAGATTCTGAATTATGAGGCACTCCCATATGAGTGAACAAAACAGGTAAACCAAGTATTTTTTAAAAAAATAGATATCAGCTGGCCACAGTGGCTCATGCCTGAAATCCCACCACTTTGGGAGGCCGAACTGGGCAGATCACCACGTCACGAGTTCCAGACCAGCCTGGCCAATATGGTGAAACCCCGTCTCTACTAAAAATACGAAAAAAAAAAAAAGATTACCCGGGTGTGGTGCCATCCTCCTGTAGTCCCAGCTACTTGGGGGCTGAGGCAGGAGAATCACTTGAACCCAGGAGGCAGAGGTTTCAGTGAGCCGAGATCACCTTACTGCACTCCAGCCTGGGCGACAGATCCAGACTCTGTCTCAAAAAAAAAAAAAAAAAAAGATATCAATTGTATCAAGGCATAGGTCCCTTTTATCTTCCCTTGTATTGCAACATTATTGTGTTTCAGTGGGGGACCAAAACCTTTATGGACTCCATTTTAGCGGAAACTTTCATAGGGAACAGCTTTGTATACCTTTAATAACCTCAGGAGTGGCCCCTTGGGAGGTGGCAGTGTCACTACACCAATAAATTTCCTCCCAAGTACTCATGGACATAAACTGTCTACTGAGACACTGGACACTACTAGAGGGGGACGGGGGACGCCAGCAAGGGTTGAAAAACAAACTGTTCCGTACTATGCTCAATACCTGGGTGATGGGATCATTTGTACCCCAAACCTCAGCATCATGCAATATACCCAGGTAACAAACCTGCACATGTGCCCAATGAATCTAAAATAAAACTTGAAAAAGAAATGACAAGGCATAAAAATGTTTTAATGAAGATGAAAACATTCCTCCCAAGTTAGTTTCATTACATGTCTTCTCATTATCCTTTATGTCTTCTGTAGGTTTGGAGTGTGTATGGATTTTTAAGGAGCCCTCAGAAAACTAACATTGCGCAACAACTGCCCTCAAATAGTTTCTAAGTTTTTAATAACTGTGGTTTTGGACAAATTTCACAATAGCTATAAGCAAATACTTATCAATGTGGGTGGAGAAACTCCCATGCAAACAGTACTTAGATTTCTCCCTGAGATCAAATATCTTTCTTGTAAGAACTGTCTGTGCTGTGACACCACGAGCTATGACTTGTTCACTGTGGGTAGCCAGCATTGCAATTGCTCWAGAGTTCACTTCCATTGAGTGTTATGTAAAACTTGCAGTTAGTATATTAAGATTAGGTTACGGAAGAATTCCCAAGCTGGTTGTTTTGTGTGTGTGTGTGTGTCTGTGATTTTTTTTTTAAGAAATGTCTTGGCCCAGGTAATGTCATGTAGTATCCATTGCCTTAGAAGCCAATAATTGTAAAGGTATACACTGTGGGTGTCGATTGCACTTATTATAATTCCAGGGATAAGAAAAAGCTATCATTTTATCTATGCAATCCCGTAATGGCTTGTGGGTATTGTATCTGGATTATAGTATTAATAACAACACCAATCACAAGCATCCTGGTTGTAATATTTGGTGCATACTATCTCTGGCCATTCCTTAAACGAGGCTCAATAGATAGTGGCCCATTGCTCCATTTGTTTAATGGCACATGAGTTAATAATAGTGGGTATCATCTGATGTGAAGGAAAAGGCGGCCCACAGAGCTTAGAAGGCATCTATGAGTCACAAGTGAAATTGTACAATCTGACTTAGCTGGAAGGATGTTACTAAGTGGTAGTACAGAGAGGAGGAGAAGTGCTAACCTCAGTGCTGATGTCTGTGGACTGACCCAGTGAAATGGGAGCATGGTTCCCTTTGTTCCCAGTCTCACCTATGTTGGGTCTCCCTGTGGTGTGTATGAGCCATGCTGTTTCCATACATACTCTGCCAGCAGTAGGGTGTGGATTACCAGGGATAGGGTGATCCACCAATCGAGGTATAATTQACATTGGTGAAGGTAGGAACTTTCTCAGGTAAGCAAAGGGCAGAACAACAGCATAGGCATAAATGTTGGAGGTCATTTGCAGCCAGCAGTAGGCAATCTGATTGTCCTCTCGGAGTCACCCAAATGGTGTTACCAGATACAAGGGTTGTTGGTTCAATCTCCTGGGTGTCCGCAGCACGTCAAGGTTTGTTCCATAGTGCCCTTAGTGGAGCAAAGTACATCCCCAGAAAATGAGGATGCTTCCCTCTCCAGATAGTGGTGGGTCGTTTGCTAGTTTTATGCTGGGTAATGAGCAGACTAAGACTGAGAATGCACCCAGAGTGAGTGGTCCATCCCAGATCCTTGTCAGGATTGAGAGCGGAAAAAAATGGCCAGGCTCTGGATTTTCTATGAGGGAGAAGGAAGAGGTGAAAGAGCCAAGTTCCTTTGCTGTGGGCACTCACTTCAGGGCCCCCATGTTCGTGAATACTGGTAAATCATGTTGTGTCCAGTGGGTACATACATTACCACAGGTTGCAGCATCTCTGTTGGTGGTCTCCTCATTTGCTGTGAATTAAAATATCGTGCATTTATGCCAGAGAGCTATCGATTTAATGTAAGCATGACTATGGGCAGTATTTTTGCCTACGGGCAATGCTATTGTCCTGCATGTTCTTTCAATATCCCTTGTTTTAAAAAGCCCATTGTGTCATTCTGTGACACCTGCTACTGTAGGACCAGAGAATAAATCACAAATCCAAGCAGTGTTCTTTCGTAATGCCTATGGTTGAATCTTCTTTGCACAGAAGTGAGAGTCTTGATCTGACTGGATAACTTTGTGTAACTTTTGTACTCCCAAAGGCCATACAAACTATTTTATCAGTTCCTCAATAACATTAGCACAGCTTCCTGCCTTTCGTGGGTAAGCCAAGAGTAAGCCTGTGTAGGAATTACTACATTGTTGTGGCATATGTAATACTTCCTGCTGCTTCAGAGAGGGGCCCAATAAAATTGACTCGATTTGCCACCTCTCATATAGCCCTTCTCCTGTGCAGTAGGTCCAAGTCTCTAGATTTCTGGTCTATGGTACGGTCCCTAACAGCTTCATGTAAATGTCTCTCTGCTGGGTCTATTTCTCATTAACAGTTGATTTTCATGGTCTCATGATGCCCAAATGCCCTGACCTCTCCTTTATAGCGTGAACGGTAGCTCTTACCAAAGTTCTCCTGTCTCCCTTCTTTTCAAAAGCATTAACTACTTTGGTACTTTAGCTAGTTTGTCAGTTTCCACGTTGTATTGTTTGCTGTGAGCTGAGGTATGGTGTACAAAGATGTGCACAGTGGAGGCCAATCTGCTGATATTTTCCCCCACATCTCCTTACCCCAAATGTGTCAGCCTTGTATGTTCCAGCCCTGATTTTGTCCAACTCCCAACCCAATAGCCTATTAGCCACTGACCAGGAGTTGCCAAAAATGTGAAACTTAGTAAAATGTTTGTCGAAGGCCTTCTCTATTTCTAGGGGTGTTGCACACAGCCTCGCCCATTGGGCACTTTGGCCCATCCCCATATGGAAGTTGGAGTATTTGAATAAGGGTAGTAGGCTGTTGCTCTCCTTTATCTGACTCCCTTATACCCTGTGCTCACTCCATTGGTAAAGAAAAACATTAATTTTCTTGTTATGAAAGTGCTGGCCATACTCCCTCCATTCCCCAATGAGCAAGAGCCAGCGGCATTTCCAGGGGTTTTGGCAAGTTAACCTCACTGACAGAGTATGTGGCCATTTCCTCACACAGTAGTCACACTCCAGGAGGGCCAGGTGTAGTTCAATCCTGTAGATACCATTTTCATTTTAATAAAGAAGCTTCTCTTGCTGATCCAATTTTATGGGCAGCTCTGTCCATTACCCAGGGCATAACACCAATCTCGGTCCATAGGGTAATTTTCTCTGCCCCACCAGCGCTTCAGTTTTGATAAGTGCCCCATATGCTGCCAGTGGGTGTCTGTCTAGTGAATACTTTAGGCTGAGGCTGAGAGCTACTTACACCAAAAGCCCATGGCTAGGCATTTACCTGTCCATTTGGTCCAGAGGCTCCAGGAAGCAAATTTCGGACCAGTGGAAACTTATAATTGCAAGTCTTGTCCTTGGGAGCACTAGAGGGAGAGCCAAAGTATTAGCCTCCTTTAGCTCAACCAGTGACTGTAGATGTTCAGGTCCCTACTGAAAAAAGGAAGCTTTACAGGTGTCTCGATAGACAATTCAGCAAGGGTCAGCAAATATTGGAGGTGAGCAAGGCATTGTGCTATAATTCCTAATGAATGTTCGCGGTTCTTTACTGATGTGAGCCGTTTAAGCATGAGGAGCTTGTCTTTTATCAGATTGCAAATAGTCTCAACACTATTTCTGTCCTGTCAAAGTGTAGAGATCTTATTCCTAGATTTAGACTGCCCTTAGGAATCCGCTCAGATAATGCGCCAGCGTTTGTGGCTGACTTGGTACAGAAAACAGCAAAGGTATTGAGGATCACATCGAAACTGCATGCTGCCTACCGACCGCAAAGTTCTGGAAAGGTGACCGAGTGTGGATCAAAGACTCAAACATAGCCCCTTTGCATGCACGGTGGGAAGGACCCCAGCCCATCATCCTGACCACTCTCACTGCTGTGAAGGTACAAGGAATCCCGGCCTGGATCCACCTCAGCAGTGTAAAACCTGCACCGCCTGAAACTTAGGAGGCAAGACCAACACCCGATAACTCAGGCCGTGCTCCGCCTGTCAGATAGTAAATCCCACGTGATGTACCTGCTGTCAGCAGATCTAGGCTTTCTTCTTGGACACCTTATACCCACACTCCTCCAGGTGCCAAAGTAGGGCATCCGTTCCCTTGGCAAACCCGACTGCTGTCCGGTGTCCTAGCAGAAGGTCCTCGACGTACTGGAGCAACACCCACCCTGGGTCTCTGCCAGGAAACTTCTGGAACTCCCCAACCAATGTTTCCTCGAAGAGATGGTGGGGGACTTCTTGAACCTTTGGGGAACCCCGGTTCAACTGTACTGAGTGGTGACACCCGACCCCAGATCTTCCCACTGAAAGGCAAACAGTTTCTCGCTCTCAGCGGCTACTCTGATGCTAAAGAAAGAGTCTTTCACGTCCAAGCAGGTCAACCACCTGTCCTCAGCTGACAGCAACCCTAACAACATGTACAGTTAGGCACTGTTGGATCTAAACTCACTGTACCTTCATTAACCAAGCACAAGTCCTGTACTGGCCTGTAGTCCTTGGTCCTTGGCTTGGGAACACGCAGGAGGAAAGTGTAGTATTCTGAGGTCTGAACAGGCAGGAGTGGAAAAACACCCTTCCGAGTTCCTAGTGTAGCCTTCAAATTTTACAGACTTATACCTTACATCGTCTAATTCCCAATCCACTCTCAGTGAGACGTGGTTTACTGAGCGTTGTGATCAACTGTCAAACAGAGTCTTGCTCACGTTCTGCCAGGAGGATGTCACCGATATAATGCCAAAGCATACTTTCTGGTGAAATTGAGGGGCAGGTGTCTATGTCCTGTTGGCAATGACTGTGCAATTGGAGGGCTATTAAGTATCCCCCAAAAAGCTAGCATCACAATGAAGATGAGGGGAAACAAATACCCCAAAAGCAAGTGGGTAAAGGCGTACTATTGACTCTCAAAGGTGGAAGTGAAATGTGTTTGACTCAACTGTGAAATTTTTACTAAACAGAACATGTTACCCAAGTCTACAACTCCAGATTCAAATTCTCGTGGCTTTAGATGCCCTGGATTAATATAAACTTACCACTGAGGTTTTGAATGACACCCATTAAGGCAACAATGTCCTATACAGGTGCTCTAATAAAGGAAACAGCCCTGCTGAACTCTCTATGGTCTATAGTCTCCACTGATTAGTACTGTCTCTTACGGCACGCCATATGGGGAATTGATACCTGAGGTAGTAGGAGTCAGTGTTCCTTGTTTATCTATGTCACCTGTGACAGGCCATAATCCTTCAGTGTCCTGCTTCAGCTTCTGCTGTGGTATATGAACCACCTGAACCAGCAGGGGCACGTTAACTGGTTCCCTCCGGGAAGTGCCCACCAGTAGCATAAAAACCTTAGTCTTATGTCATGAGTTTATCTGCGGCCTCAGGAGGTCTCTTCCAATAATGGGGAAATGGATAATCTTCGAGGGCAGGCAAGCAGGACAGAAGCATATTTTTAGCAAAACTGAGCCAATTTTAATAGTTAAGAGGGGAATTATCCCTTTAATTAATCCCTTTAATTAACCCCCTTCCAAGCAGCTAGCCTACTTGCCAGGAGGCGGTTCCTTTTAAAGCATGTGTGTGTCTTGGCATTAGGCAGATTTGGCCACCCCTGACTGACACAGTTACCCAGTGTTGTTTGTCAGTGCCCAAGCCACAGTTAATATGGTGAAAGGGCAACTGTCTGTCAGAAGGGGCCTTCCGACACTGCAGCATCCCTCTGTGAGAGAAGATTCTTAGCCATTTGGCAAGCATCAGAGACAGGTGTGGAAGATAAGGTTACCTCCAAAGGGAAAGCCAGCTGGGGTGGGAGGGGGTCGTAATCTAACCCTAGTAAGTATTGCAATTGCTCCAAACATTCACCAGAGATCATCCAATTTGGCACCTTCTTGTGCCTTAGCGTCTAACATAACCTCTTTTCGTCATCTCGTGGTTGATGCATACATCCGATCCTGGCCACACGTGCTTTGTTTGGCCCAGGAGCCCCAGCCTGAGTCCTGATAGTAACTTTGATTTAGGCCACGTAGGGTATTATAGTGTTAGCACGCAGCACCTGACTCTGACTTTGTCTTTCATGAGTTTCTATTAAATCCAGTCCAGCTATGGTCTCTTGAATTGTTTTAGCAGTAGCCACCATGCCCAGTAAAGAAGATTTTCCCAGGAGCCCCGCCCCCCGAGGAACAATTGAGTGGACTCAGGACTCAATTCAGACTCCTCCAGTCTTGTCAAGTCATCCTGCCCCACCTCATTTGTTGCCTCCACTCCAACATGTCCAACTCGTGGAGGAGATGTTTGGCCTTGGCTAACCTTTTCCCTGGACAGTCTTCCCAGGCCATTATGAGGTCTAATGGTGGGCAGTCTTCTAATCCACAAAATACACATCAGCAATAAAGATGTGAACAGAGGTCCAATGTGGCTTCTTCCCAAAATTCTGCTCTAATTATACAGGTTCCTTTACTGGGGACACAATTTTTCCATCATGTACTATCGCTCCTAATTGTTTAATTTCATTCCCCATTAGGTGGAATCAGTTCCCTGCCAGATGCATTCTCTAGAGCCAGGCAGCCCCTTGTTTATTTGGTTCTTGGCCTGGGTACTTAACGACAGACTGGGGCTCGGGTAAGACAGAGGATAGGACTCCTCCTCTGAGCAGGAACAGACCCTTCCTTCTTGGCTCTCCCTTTTTTTCTTTTCCATTTTTATTACTTTCTGGGTGGCTACAGGCAAAGCAGAGGGTAACTTTTCCCAGTCCCTACCGTGGTGACACTGTGCTGCCTTTTCTTCTGGAGAGCACCTATTCTCCTCTCCAGGGACCTCTTGTCCAAACTGTCTCTCCCAAGAGTTTGGGCTCTTACCTCTTCTCCAGGTGGCATCCTGGTGATAAATTGCTGCCAGCAAGGTCAGCACATGCCTCATCGTTAGGAATCCTTCTTCCACCTGACAGCACCTCCTGTAGGGTTCCGGAAAGGGGTAGGAATATAAATTTCTTTGCCTTCAGTCACTTTAAGTACCACTCTAGCTAGCTCAGTCCAAAGGTTGAGATATTAATATCCCTCTGGAGAGGGGATAGCATGATGACAACTGCAACATCATAATTGAGTGTAACAACAGTAGAGCCATGCTACCTGCTTGCAAAGGCCTTTCCACCAGCTCCCCTTAGGAGACCAGCCTTGGCCTGATGTCTCTGCCTTATTGGCTCATTTACTTGCCTATCTGTCTCCGGGGAGGAGGAAATCCTCACATCTCAGACTACCCCAAATCCTCAACCCAGCCACAGGGAGCACTTCCCACCATAGCCTGTTATGCAGTCCAGGGTCGTTCACCCTTATTCCAGAGGCATGCACTCCCTCTCCTTTTCTATTCAGGTACACAGGTGCACAATGTCCAATGTCAACTGAGGGGGGGACCCACGTAAGTGGGCTGACCTCCTTCCCAAGTACCTTGGCATCTAAGACCCCAAAAGTCAGTTCTAGTGGTGTGGGTTCACTCAACTACTGGTGCTACCTCTGGGCCAGGTCAATGAGGTATAGAAGGAGACTGCAAAAAGTATATTGTTGCGGTACAGCAATGAGCGATGCTAAGCAAAACTGCTACAGAGGCATTCTAAATGTAGAGTCTGAGCACTTAGGCTGCCTAGGACTGATTTTTCAATTGATTGTCCTACTGACTGGGTAGACGCTATGCCAAATTTCTTGTTCACCAAAATCCCATCCTCCTCACCACTTGTCGTGAGTTCCAAGATTTCTGGGCTGATCAATGAAGAAGACATGACCACGAGGTCGCAGTAGCGCCCAAAAACATTTTTTTTTTTTTTTGAGAAGGGAGAAGGAGTCTCACTCTGTTGTCCAAGCTGGAATACAGTGGCGCAACCTCTGCTCACTGCAACCTCCGCCTCCCGGGCTCAAGTGATTCTCCAGCCTCAGCCTCCGAAGTAGCTGCGATTACAGCCTCCCGCCACAATGGCGGGCTAATTTTTGTATTTTTTAGTAGAGACCAGGTTTCACCCTATTGGCCAGGCTGGTCTCAAACAGCTGACCTCAGGTGATCCACCCGCCTCGGCCTTCCAAAGTGCTGAGATTACAGGTGTGAGCCACCGCGCCCAGCCAAGAACCTTTTTATTTCGGCGGTGCTTTGACAGGTTGCCAGAAAGGGGAGGTCTCTCACATCAGACCTTCCAGAGGCAGCAGCAGAGGGCCACTGAGCAGAAGGGGAAGAAGGCAAGGTAACTCCTGGGGTAGAGGAGAATAGGAGAGGGCCTTATCTGTCTGGGCGATATCACTCAGCAGCAGGAGAGGGAGTCTCTGGGTCAGAGGGTTCTGGAGCCAAGCAGTGGCATCGCGTCTTTTATAGCCCCTGTCTTTTCTTTAAATGTGGCTAGCAGATGTCAGTGCAGTTTTGTGGGGCATGCAAGCCAGGCAAGCCCTAAGTGGCTACACATATGCTTACTTGAGCTATATTTAAAGCAATTGCATATGTGAAAAATTCGAGTTTGGCGTTGGCAGGCTTTCTGCCTGCTGTGAGGAAGTATAATGGCAATATAAAGGCTAATATATGGAGGTCATCTTTAACCCACTGATATAATAACATGCCACTTAGTCAGCCACTCTGATTAATCCGACTAGCATGGTCTGAGATAAAATCCATTCAATCTGTACTGTCAACAGTACTCTAAGCAGCAAGGTGAGATCAATCTGCAACGTTAACCCGAACTTAAAACGTTAAGCGCACACGTACAATACTACTGCTCCTGAGTTTTTATCTAAGAGAAATGAAAGCATAGGTCCACATAAAGACTTGTATGTGAATGTTTATAGCAGCTTCAATTGTGCTAGTGAAAAACTGGAAACAATCCAAATTACCATACAATGAAATACTATACTATGACAAATAGTAATGAACTATTGATAGAAATAACAGCATGGGTGAATCTGAAAATAACTACGCTGATTTTAAGAAGACAAAAAAGAGTATACAGTGTATAATTCTATTTATATAAAATTCTATAAAGCACAAACTAATCTATAGTGAGAGAAAGTAGATCAGTGGTTGCCTAGGGACAGGGATGGGATGGGGATGGGTAGGGAGGGAAGCAACATAAAGGGGCATGAGAAAGCCTTAGGAGGTGAGTAAAATGATCGTCATTTTGAATGTGGTAAGGGCTTATGATTATTGGTAAGGAGTTATGCTTATAAAATATAAATAATTTGTATTTTATAAATTATATAAATTACATATAATTTCATTTAGTTTTAAATTTAAGGAATGGCAATATGTCTTGCATCAAAGAACCCTCAAAACAACACCTTAAGTACTGCAAAGTCTTTGACGATGTATTTGTTGAGTTAACTTATCTTTAAACATCAATAATAAATAAAATGGTCAAGACTTATTTGTTTCTATGTGTTTATTTTAGTGTGCTATTGCTTTTTCACATTCTGGGTCATATTTTCAAAAGTATTATTTCACATTGTGTAATGTATTTTTTTTTCACTATTAGTAAAGAGCATCTCAAGTAAGGTCCTACTTTCTACTTTGATGGTATACGAGCATGTTTGACTCAGATATGAACCACTTCTGGACAGAGTTATGGGTGAGAAATCTGATATTTAAGCAACACTCTGGATTACTTTCCACTGGTGAGAATAAAAAAAAGTGATGAGCACTTTTTCCAAATACCACGTGATGAATCAAGTACTCAAACATGCTAACTGCATTTAGACTATTCTATTACCAAAATATTCCAATCAATGCCTGTGGACAGTTTGTAAACTGTCATTCCCAATGCCTCCTCATTCTTCAAGTTCCCACTGAAAGGTCTCATAGCTTATCAGACCTTTGGGGGAAGTGCTTTTTTTTTTTAATTAAAAGTTAAGTCATGTGCAGGGCAGAGTGAGGCAAAATGCAGCGAGTGGTTAGGACCTAAAGACCTCTCCTTCACCTGGGCCTTGAGAGTTTCAGAGAACCTCAGGAAGAAAAGCCAACCATCTGAGTCCAGTGGCCTTTGAAGCAGTGGTCTTGCATCTGTACATGTGGGATAAATGATGTGAAAACCATTAACTCTGCTGCTGATCCAGCTGCAGGGAAAAGCATTTCCTCTGATCAAGGTGAACATCTGGCTGGTGGACCTCATTTTGCACCAGGTCCTGATCGATGAGCTGAGCCTGAGTCCACAGTTCACCTGATGGAGAACTCAGACTCAAAGCCCAGGCCCAAGTGAGGCTGTCTGACTGCTGCTTGAGGGCCTAGGGACCACACCCCTGGAGTCAGGACGGCAGAGGTGAGGATGACAGTGCAATGGCCAGAAGGTAAAGATACATGTGAATATTCTATCTCCATTAGGTCACATGGATGAGGCAAGAGAAAAAAGTAGCATATACATTTTTGAGAAGTTAAAGCTGATAGGACACAAAGATGGTTGATTGTTCTACAGACGTGGAAGGCAGGGGCTTAGGTCCTGTAAAGTCCCCCACTGAGCAAATAACTGAGACAGTACTTCCTAGTGATGCATTCTGCTGTCAAACAGTGTGAAATTTTCCTGGAGAAGGCTCAGGCCATCACTCCCTGGTCCATCTTCTCCCCCCACAGAGATGCTCATCCAACACCCTCCACAGGGACAGCATTGCACAAGTGATTCCCTTTTTAGAAATTCTTCTAAGCCAGTCAGAAGAAGACAAGCTTGCAGATGGAAGGGAATCAGAACCTGGGCAATATCTTGTAGTGGCCGACCTATCCCTGTGTGTGGTTTGGAGTGTTTTCACTAAGACAAAACAGTGGGAGAAAGAAAAACCCTACACCCATACAAACTTTGAGGGAATACTGGAGCTTATTGTAACAGACACTGGTCATGCTATGAAATTTTATTACCTTTTCTGGAGCCGTCGCACGGCTTTGTCTTTGGGCTGCTTTCCGTGGTGCAGTAATTGTCAAGCTTGCCAAAAGTGTGACAGAATCACGGAATTACCCTTGGCAGAAACGCAGAATTACTCCTAACCTCTACTCTCATCCTCCACCTGCACCAGACAGACAAACAACTTCTTGAGTTTTCAGAAACTACCAAATCTTGGCTCTAGCTCCGCATCCTTGGCCAGAGCATGGAAGGTTGGGGTGAGGGACACGGTGAACAAAAACTGCATCCTCGAGCTGCTCGCACTTCCTCTTTCCCTCTTTGGTCTTGTGTGTGCGCTCACAGGTTACCAGGCAGGGGTCACTAAGGTTGTCAGTGGGACGATGTCAGCCCTACTCCCTTCCTCCCAGGCAGCTCAACATCCGAGGCTCCCAATTCCCCTTTCTCCTCCAACGAAAGATACCACAGCTGTGTCATTCTCCTTCAGAGACTGCAGATTGGAGGTCTGTTTTTCCACAAAACCTACTTCTAAGACATTTCTAGCAACTGAGAGTGACTGATTGGAAATCTAGTGGTGACACCTACCCATGGAACAGGCTTAAATAGCGACTCCTCCTTGTAGTGAACGAATTTCAGATTTCACACAAGAAGGGCAAAACCATGGGCTATTTTCTCCCATGAATTTTTGCCTATTTTGGGCCCTAAATCAAATTGACAAAAGTCTGACTAAAACACTCAAACTGCCAATATAGTTAGAGATATACACTTTGTGAGACTAACTCGGGAATCTACTGCCCTGCTTCTGCAAGGATAAGGCTCTGTAAGGCATGACTTGAAAAATGATCCAACCACCTTTTATCTGTTTAACTCTCGTGCAGGAGAACAGAGCAGCATTTAAGGTATAAATTAAATTAGTCTATTCCTGAAGAGAACATTTGCTACTCACATTTATGGTGGAAGATGCAATCTCACAACACAACAAAGCTCTCCTTCTGAGTGGAGCACGCCAAATACTGGGTAGGGCTAGACTATAAGCTCACAGGCTCTATGCCCTAAGCTACTGATGCCCCTTTGTGCCAGAGGCTGGGTTTTGCAACAAACTCAGTTCAGCTCTCGGAACACTGGCCCCACCGAGAATCCTAAATAGTCAACTAAAATCCCTGAAATACCCAGGCCTGTTTCTTTAATCATTAGTATTGTTTGCATACCTTTAGGAGGTACAAGCGCAGTTTTGTTACATGGTTATATTACCCACTGGTGAAGTGTAGGCTTACCAAAGCAAAAACAGGGTGGTAGATAATCTCCCTTGTGCAATCAACAACTATAACCCTGAACACGTAGGGTGCCTACTATTCATACTGACTACAGAGAGCCTGGACTCCTCTAACCTGATAAGGATATGAAGCCAGTTATCTATTTATTACCTCTTAGCTCCAAATTCACCAGTCAATATATATTCTTCGATAATA0AG0GATTCTTTAAGCATCTCTCCTTTAAAGTAGCATCAAAGAGCACGATGTTACACTTACTTAATAGAGGGCTCTGGAGGGACAGACATTGAAAAAGGAAGGGTACTTCTATGATTTCTGGCTCTCAGAGGTGTGGAGGTAAGGACATTCAGGATGCTTTGTCCCAGGCCTGGGCCCAGAACAACTGTCCCTCAGTAAACCTGCAGTCCTGGTGTGCCCTGATGATCAGCTTCTTGTGGCCCTCTTGATAGGGACATCCTGTACTCCAAGTCATCTGCCCACTCCTTCCCTCTGCTCACTTGCTCCCCAGCCACACACACACACACACACACACACACACACACACACACACGACCAGGTTCATGTAGTCCTTTCAATACTGCACCCCTCTCAACACCCAGCCCCCACCCTGATCCTGTGCAAGGGGCATTGTTTACTCCAGGCCTCCAACTGAGACAGGACTCCCAACCCCTACTTCACACCACATACTAGGCACCAGCTATGGCTTGTCCACACTACCATGCTCCAAAGGGTGCCTTCTTGCTTCCTCTGCGACCGTAGACCAGTTCTGCCTCTGTAGACCAGCTTAGGTACTGGCAAACCAGTGGAACTTCTCTGCCATCCAGTAGGTTCTTCTCCAATTAGGTATAAATCCATCCTTGGGGAGAACCTTTCATTCTAAGCTTGTCTTTCCTTGGGTACTCTCTCCCAGCCCCAGAAAAACCCCACATAGAGTTGTCTTGTATCCTATACAAGATCTTTTATCATCGCTTAATGATTCTTTATATTAAATTTTCCCCTTCTAGATCACTGTGTGCTTTCTATCTCCTGATTGGATCCATATTGCTGCAGAACACAACATCTACAGCAAGCATCATTCTTAATGGAGAATCACTGAAAGCTTTCTCTTCAAGAGCTACATCAAGTAAGGATATCCACTATCACCACTTCTATGCAATAGTTTACTGGGGCTAGGGGCGGGGTCCCAGGCAGAGCAGTAGGGCAA0AAAAA0CAATAAGATATTTGGAAACGAAGAAGAAAGACTGGAACTATTTTCAGATGATATGACAGTGTATATAAAATTCTACAAAGTATTACAGACAAATTATTAGAATCGATAGAAGAGTTTATATGCTTATAGGATAAAATCTTAACGAACAAAAGCCAATTGTATGCTATTTAGAGCTATAAATTTAGACAATAAAAATTTCAAACATATGATTTGCAAAATATTAAATGCCTAGGATAAAAAAGTTGCCTTGTGGGAAAAATATAAAATAATATTTGGGCAAATTAAAGGTGATCTTATTAACAGAAGAGATAGACCATAACCACCAATCGAACATTCAATATTGAGAAGTCAAATCTAAAATATCAGCACAATTCAAATTACAACCCCAAACTAGCTGTTGGTTGAAGTTTTTACGATTAGTTTATAATTTAAATGGAATTGAAATGGACCAAAAGTAGCCAAGACACTTTTGAAGAGCAAGGTAGAATTGATTTGCCTAAATCCAATATCAGAATTGACTATGGATCTGTAGTAATTAAGACAGTGTCCTATTTCAAACAGACAAGTCCTTAATAGAGAGTATAGAACTAGCCCACATATGTGTAGATACTTGATTTATGGCACTGTAAATCAACTGGCAAAAGGCAGACTTTTCAATAAGTGGTTCACTGAGAAAACTGGATATTCACTTACTTACATACATATATACATAAATGGAACTCTACTTAACACAATACACAAACATCAATTGCAGGTGGATTAAGACCTGACTATGAAGGACAATAGCAGACATATTTTAGAAGAAAATATAGAGAATGCTTTCATGGTCCAGGGTTCCTTAAAACAGAAAAGATTTCTTAAAACAAAAAAGGAGTAACCATCAGGAAAAGAATGATGAAATTGACTATATTATAATTAATAGCTTCTGTTCACAAACCGGAGCACAAAGCAAGTGAATATACAAACAGAGCAAGGGACTATTTTGGCCGCAGGTGTGGAAGAGTATTTAAAATATTTAACAGACTCATTAAGTCAGTATCAGATGAACAATAAAATAGAAACGTGGGTTAAAAGAGGTAAATTTGAATAGGCCTTCCTCAAAATAGAAACTCCAAAAGGCTCATTAACACAAAAATGTGCTAAAGCTTAATAGTAATTTGCATATTGCCCACCAGTAGACCGCCAAAATTTAAATTCGGGCAATACTTGGTGTAGGTGAACATGTGGATCAGTAAGGACTCTCTATGCTGCTGGTGGGATTGACAACTCTCCCAATCACTACAGAGAACAATTTGGCATCATCTACTAAAGCTGAGGATATCCATTCCCTATGGCCCTGTGATTCTATTCTTGGATATATACCCTAGAGAGATTTTTACACGTGTCCCATTAGAAATGTGCAAGAATGTTCACAATAATCATTGAAAAGTAGAAGCAATCCTAATCTCCATCTGCTGTAGAATGGAGTGGAATAATCATACAATAATCACTTTGCTATAAGCATATGCTGGAAAGACAGTCGATGGAGACAAAGGATCTACTTACTTATAGCTATTATGAACAACATGGACGAGTCTCTCAAGTATAATACAGAGTGAAAAAAGCAAGCTATAAAAGGAAGCATGCCGTATGATTCCACTTATACAACTTCATATCAACTCTATTGTTTAGGGATGCGTACAAAAGTGATAAAGCTATAAAGGAAAGCAGTGAAATGATTATTACAAAGTCGGAGCAATTACTATATCTATATAGGAGAGTGTGGTTTCTGACTGGAAGGAGTACAGCAGCTGTATTCTGGGAGGTTGGCAGTGGTCTATTGCTTGACCTTGGTCCTGGTTAAGTAGGTGTCTGCTTTTGTAAAATAATCTAAACTATACAGATACGTTATATGCACTCTTCTAATTTCAGATTTGAAAAGTGCTTCCTCCAGAAAAAGTAATAGAAAGAAAAGTATGTGGAGTAGAAATTTTGATGAGGTTCGAATAGTTATGGTTGAAAAACTTGATTTTCAAGAGACCAAGTGTCCACTGTTATTAAAAGAGGGCGAGAGAGCTGGGAGTATTTAAACAACAGGTTACACCCCCCCACCCCCACCACCACCAATCTGTTCATCACTCTAAGCCTTCTCATCTCAGATATTTCACCCTATATTTGTGTCAATTCCAAACTCATTCGTGACAGACAAATTGGAGGATTGTCGTCATCATTAATAAGGACATTAGGCACCAAAGGCCCAGCAAGACTGGGCCACCACACTTAAATGTGAGCAGGTACACCGGGCCGAGTGGACAAGATCGTCTGTGCACATTACTTGGCAGAGTCCATTGAGTGACTGAGGGTTTAACCTTAACACATTTAACTGGAACTCCTCCCCAGAGAATGTGCTGGAGAATGCAGAATAAACTGAGCAATGCCCTCATTGTGCTATGAGAGTGGACATGAAGTTTATCATGGTACAACCGATCGTCGAAGCGCAAAGAGTTGGTTTAGGTTGTCCACTGTATAGGGAGAAGCCAGGGGCGGGTTGCGTTTTTTTCCAGATTTCAGTATAAATTGTTTCATCCTCCAGACTTTGCATTTGTAGGCTGAAGAGTCCTAATCTGTTTTGGCCGCATCTCTCACTCATTCTAATCTCTGTTATCAGCAGACAAAAATTGAACTATGTGGCAAATTGTACC0AGCACTTTGCTCAAGACAATTCTGAGTATGGAACTTGTCCCGCGCAGAGGTGGGAAGGCCAAGGGCAATTTCCGCAGAAATGCCAGCACTATGGTGCTTTAATGCTGACACAGAGACAGTTTTTTCTCTCAGGAATTGTCTTTCATCCATCAATCCAGCCAGGTAGCCAGCCAATAAACAAATTTTAACACACAAAAAGTATGAAGCAACATGTCTAACACTGGGAGGGGCTGGCGTGTGTTTATTTGGGTATATACAATGAGTCAC0GATTAAAATTGCTTTTACCAGATAGATACCTAGGTGTTCCACAGCATTATTGAACAAGATGTCGTCATTTCCCCATTACTTCAGAAGACCTCCTTAATTACTTATATTAATTGTAGAATATATTTATGCATACCAGGCTCTACCTCTGGGCTTTCTATTCCGTTCCAGAGACCCAGTACCAGAATATTTAAATCACTGTGGCGTTGAATACATTTTAATATCTGATAGGGCCAGTTTCTGCGCATTGCACATTTTTTTTTCCCCTTTCACGAACGTGTTCACGCCCGCCGCAGGGGGCGGGATCGCCCCTCCTCCTCGGCTCTGGTTCCAGCCGAGCCTCTCGGACGCAGAGATGGAAATCCCGAAGCTGCTCCCGGCTCGCGGCACACTACAGGGCGGCCGCGGCGCCGGTATCCCCGCGGGTGCCGGCCGAGTCCACCGAGGCCCTGACTCGCCGGCTGGCCAGGTCCCCACGCGCCGCCTCCTCCTGCCCCGGGGCCCCCAAGATGGCGGGCCCGGGCGGCGGCGCCAGGAGGCCAGCACGGCATCACGGGGCCCTGGCCCAAGCCTGTTCGCGCCGAGGCCCCATCAACCTAGCGGCGGCGGCGACGACTTCTTCCTGGTGCTGCTTGACCCGGTGGGTGGCGACGTCGAGACCGCGGGCTCCGCTCAGGCCGCAGGGCCTGTGTTGAGGGAG0AGGCCAAGCCGGGCCCGGGGCTCCAGCGGGACGAGAGCGGCGCGAACCCCGCCGGCTGCTCTGCGCAGGGCCCCCACTGCCTGTCCGCCGTTCCCACTCCGGCCCCGATCTCCGCCCCCG0CCCCCCCGCGGCCTTCGCGGGCACAGTCACTATCCACAACCAGGACCTCCTGTTGCGCTTTGACAACGGCCTCCTCACCCTCGCCACGCCCCCACCACACCCCTGGCAGCCAGGGCCCGCTCCTGCCCAGCAGCCCAGGTCTCTGATCCCCCCCCAAGCTGGGTTCCCCCAAGCCGCGCACCCGCGTGACTGCCCAGAGCTCCCGTCCCACCTCCTGCTAGCCGAGCCCGCAGAACCCGCGCCTGCTCCGGCGCCCCAGCACGAGCCCGACGGCCTGCCCGCCGCCCTGCCCCCCCCCGGACTGCTCGCCTCTGGTCCAGGCGTGGTGCTGTACCTGTGCCCCCGAGGCGCTGTGCGGGCAAACCTTCGCAAGAAGCACCAGCTGAAGATGCACCTGCTCACCCACAGCAGCACCCACGGCCAGAGGCCCTTCAATGCCCCCTGGGTGGCTGCGGCTGGACCTTCACCACCTCTTACTAAGCTCAAGAGGCACCTCCAGTCCCACGATAAACTGCCCCCCTTCGGCTGCCCTGCCGAGGGCTGTCGCAACAGCTTCACCACCGTGTACAACCTCAAGGCGCACATGAAGGGCCATGAGCAGGAGAACTCGTTCAAATGTGAGGTGTGCGAGGAGAGCTTCCCCACGCAGGCCAAACTCGGCGCCCACCAGCGCAGCCACTTCGAACCCGAGAGGCCTTACCACTGCGCGTTTTCTCGCTGCAAGAACACATTTATCACACTCAGTGCTCTGTTTTCCCATAACCGCCCCCATTTCAGCGAACACCAACTGTTTTCCTGCTCTTTCCCTGGCTGCAGCAAGCAATATGACAAGGCTTGTACGCTGAAAATTCACCTGCGGAGTCACACCGGCGAGAGACCTTTCCTTTGTGACTTGATGGCTGTGGCTGGAACTTCACCAGCATGTCCAACATTCTTAAGGCACAAAAGGAAGCACGACGATGACCGGAGGTTCATGTGCCCTGTGGAAGGCTGTGGGAAATCTTTCACGAGGGCCGAACATCTGAAAGGCCACAGCATTACCCACCTGGGCACAAAGCCTTTCGTGTGTCCTGTGGCAGCCTGCTGTGCCAGGTTCTCTGCTCGCAGTAGCCTCTACATTCACTCCAAGAAACACCTGCAGGATGTGGACACTTGGAAAAGCCGTTGCCCGATCTCCTCTTGTAATAAACTCTTCACATCCAAGCACAGCATGAAGACGCACATGGTTAAAGGCATTAAGGTGGGCCAGGATCTCTTAGCTCAGCTAGAAGCAGCAAATTCTCTCACACCCACCACTGAACTTACCAGCCAGAGACAGAATGATCTCACTGATGCAGACATAGTGTCTCTCTTCTCTGATGTACCTGACAGTACTTCTGCTGCATTGCTGGACACAGCATTGGTGAACTCTGGAATCTTGACTATTGATGTGGCTTCTGTGAGCTCGACTCTGGCAGGCCACCTCCCTGCTAATAATAATAATTCCGTAGCCCAGGCTGTGGACCCTCCGTCCTTGATGCCCACCAGCGAACCCTCCTCAACTCTCGATACCTCTCTCTTTTTTGGAACGCCCGCCACTGGTTTTCAGCAGAGCTCCTTTAATATGGATGAGGTCTCAAGTGTAAGTGTGGGGCCATTGGCATCTCTGGACTCTTTGGCCATGAAAAACTCCAGTCCAGAGCCTCAGCCTTTGACACCCAGCAGTAAGCTAACAGTGGACACAGATACTCTGACTCCTTCGAGCACCCTTTGTGAAAACAGTGTCTCACAACTACTGACACCAAAACCAGCGGAGTGCAACGTACATCCTAACTCTCACTTCTTTGGACAGGAGGGAGAAACCCAGTTTGGATTCCCCAATGCAGCAGGAAACCATGGTTCTCAGAAAGAAAGAAATCTTATCACTGTGACTGGCAGCTCATTTTTGGTATGAAGCAACTCTATTCATTCCTTGCCATGTGCCTAACTTTTATTACAGTCAATTTTGAGGATATTCTCGACTAAATATTTAAGTGCAGTCATTTCTTTTTGGTTTGCAAAAAGAGCACAGCCCTGGACTATCAGTTTGGAGATCTAAATTCTGATCTTGAGTCTCGAACTGACAAGTTGTGTGACCCTCAGCAAGTCACTTACCTATCTGAGCCTTAATTTCCTTATTTATAAAATTGTGGTGGTTTGAACACATTGCTCATAAGGTCTTTTCAGTTTTGTTTTGTTTTGTTTTGTGATTTTGTGCTTTTTCTTGAAAATTTTCGGGCATTTTGCAATTATTATTGTTTGTACTTGTAATCAGAAGCGGTTTGAGCCCTGTAGCACTAAATAATGAAAGATTGAGGAACTGGTGTTTTACATTAAAAATTTAATGGAAATTTTACACAGTACGAAAATCTAATGATAGAGCTCAAAAAAAAGAGCTAAA.AATAGGACTTGGTTCTTCTTAGCTGTTTATCCTTCTAACCTTTTTTTTAAATGATGAAGGTATGTTTTTGTTGTGGAAAATACAAGGGCTTTTGTTATCACTCAGACCCAGAGTGAAATGTTTGCTTTGTGGTTTTGAATAAGTTGGCCTTTAATAGTTATTTAGTCTCTCTTAGCCTCATTTTCTATCTGTAAAAAATGGTCATAGCAATGTGAACATATCTGTTACATCCTAGACTTATTTTTCTACCCCAGTAGGTTGTATTGAAGGAAAAATGTTATATGTGTTTCAGCATGTTTTGGTGAATCTTCATTCCCTTTCCTGCCCCTTGTTTTCCCTCCTCAAAGGGGAGAAATTAGCACAAATTAGTATCAGGATTGTGCAGGAAATAAACATTTCTGAACGTTAAGAAAGAGGAAAAGGAAGTTATTTCTTCAACAGATTAAGGATTTTTCTACACACAGTTCTTTTGTGGCATTGGCCACATGTCCATTAGACCAATTTGATAGTATCTTCGGTCTGCATTCAAAGCCAGCTCATGCAATGACTATTCAGCCTATTCTTCCAACACAATCTGGACATAGACCAGAGGGAGATTTTTCTCCCCTCTGTGCCCTAGAGAGCTCATTGCTGGCTTACTCTTAGAGTTGAAATGAGAGGGTTTTG HUMAN SEQUENCE - mRNA (SEQ ID NO: 23)CTGCTCGCGGCCGCCACCGCCGGGCCCCGGCCGTCCCTCGCTCCCCTCCTGCCTCGAGAAGGGCAGGGCTTCTCAGAGGCTTGCCGGGAAAAAAGAACGGAGGGAGGGATCGCGCTGAGTATAAAAGCCGGTTTTCGGGGCTTTATCTAACTCGCTGTAGTAATTCCAGCGAGAGGCAGAGGCAGCGAGCGGGCGGCCGCCTAGGGTGGAAGAGCCCGGCGAGCAGAGCTGCGCTGCGOGCGTCCTGGGAAGGGAGATCCGGAGCCAATAGGGGGCTTCCCCTCTGGCCCAGCCCTCCCGCTTGATCCCCCAGCCCAGCGGTCCGCAACCCTTGCCGCATCCACGAAACTTTGCCCATAGCACCGGGCGGGCACTTTGCACTGGAACTTACAACACCCCAGCAAGGACGCGACTCTCCCCACGCGGGGAGGCTATTCTGCCCATTTGGCGACACTTCCCCGCCGCTGCCAGGACCCGCTTCTCTGAAAGGCTCTCCTTGCAGCTGCTTAGACGCTGGATTTTTTTCGGGTAGTGGAAAACCAGCAGCCTCCCGCGACGATGCCCCTCAACGTTAGCTTCACCAACAGGAACTATGACCTCGACTACGACTCCGTGCAGCCGTATTTCTACTGCGACGAGGAGGAGAACTTCTACCAGCAGCAGCAGCAGAGCGAGCTGCAGCCCCCGGCGCCCAGCGAGGATATCTGGAAGAAATTCGAGCTGCTGCCCACCCCGCCCCTGTCCCCTACCCGCCGCTCCGGGCTCTGCTCGCCCTCCTACGTTGCGGTCACACCCTTCTCCCTTCCGGGAGACAACGACGGCGGTGGCGGGAGCTTCTCCACGGCCGACCAGCTGGAGATGGTGACCGAGCTGCTGGGAGGAGACATGGTGAACCAGAGTTTCATCTGCGACCCGGACGACGAGACCTTCATCAAAAACATCATCATCCAGGACTGTATGTGGAGCGGCTTCTCGGCCCCCGCCAAGCTCGTCTCAGAGAAGCTGGCCTCCTACCAGGCTGCCCGCAAAGACAGCGGCAGCCCGAACCCCGCCCGCCCCCACAGCGTCTGCTCCACCTCCAGCTTGTACCTGCAGGATCTGAGCGCCGCCGCCTCAGAGTGCATCGACCCCTCGGTGGTCTTCCCCTACCCTCTCAACGACAGCAGCTCGCCCAAGTCCTGCGCCTCGCAAGACTCCAGCGCCTTCTCTCCGTCCTCGGATTCTCTGCTCTCCTCGACAAACTCCTCCCCGCAGGCCAGCCCCGAGCCCCTGGTGCTCCATGAGGAGACACCGCCCACCACCACCAGCGACTCTGAGGAGGAACAAGAAGATGAGGAAGAAATCGATGTTGTTTCTGTGGAAAAGAGGCAGGCTCCTGGCAAAAGGTCAGAGTCTGGATCACCTTCTGCTGGAGGCCACAGCAAACCTCCTCACAGCCCACTGGTCCTCAACAGGTGCCACGTCTCCACACATCAGCACAACTACGCAGCGCCTCCCTCCACTCGGAAGGACTATCCTGCTGCCAAGAGGGTCAAGTTGGACAGTGTCAGAGTCCTGAGACAGATCAGCAACAACCGAAAATGCACCAGCCCCAGGTCCTCGGACACCGAGGAGAATGTCAAGAGGCGAACACACAACGTCTTGGAGCGCCAGAGGAGGAACGAGCTAAAACGGAGCTTTTTTGCCCTGCGTGACCAGATCCCGGAGTTGGAAAACAATGAAAAGGCCCCCAAGGTAGTTATCCTTAAAAAAGCCACAGCATACATCCTGTCCGTCCAAGCAGAGGAGCAAAAGCTCATTTCTGAAGAGGACTTGTTGCGGAAACGACGAGAACAGTTGAAACACAAACTTGAACAGCTACGGAACTCTTGTGCGTAAGGAAAAGTAAGGAAAACGATTCCTTCTAACAGAAATGTCCTGAGCAATCACCTATGAACTTGTTTCAAATGCATGATCAAATGCAACCTCACAACCTTGGCTGAGTCTTGAGACTGAAAGATTTAGCCATAATGTAAACTGCCTCAAATTGGACTTTGGGCATAAAAGAACTTTTTTATGCTTACCATCTTTTTTTTTTCTTTAACAGATTTGTATTTAAGAATTGTTTTTAAAAAATTTTAAHUMAN SEQUENCE - CODING (SEQ ID NO: 24)ATCCCCCTCAACGTTAGCTTCACCAACAGGAACTATGACCTCGACTACGACTCGGTGCAGCCGTATTTCTACTGCGACGAGGAGGAGAACTTCTACCAGCAGCAGCAGCAGAGCGAGCTGCAGCCCCCGGCGCCCAGCGAGGATATCTGGAAGAAATTCGAGCTGCTGCCCACCCCGCCCCTGTCCCCTAGCCGCCGCTCCGGGCTCTGCTCGCCCTCCTACGTTGCGGTCACACCCTTCTCCCTTCGGGGAGACAACGACGGCGGTCCCGGCAGCTTCTCCACCGCCGACCAGCTGGAGATGGTGACCGAGCTGCTGGGAGGAGACATGGTGAACCAGAGTTTCATCTGCGACCCGGACGACGAGACCTTCATCAAAAACATCATCATCCAGGACTGTATGTGCAGCGGCTTCTCGGCCGCCGCCAAGCTCGTCTCACAGAAGCTGGCCTCCTACCAGGCTGCCCCCAAAGACAGCGGCAGCCCCAACCCCGCCCGCGGCCACAGCGTCTGCTCCACCTCCACCTTGTACCTCCAGGATCTGAGCGCCGCCGCCTCAGAGTGCATCGACCCCTCGGTGGTCTTCCCCTACCCTCTCAACGACACCAGCTCGCCCAAGTCCTGCGCCTCCCAAGACTCCAGCGCCTTCTCTCCGTCCTCGGATTCTCTGCTCTCCTCGACCGAGTCCTCCCCGCAGGCCAGCCCCGAGCCCCCAAAACACCACGCTCCTCCCAAAAGGTCACAGTCTCCATCACCTTCTCCTGCAGCCCACAGCTAAACCTCCTCACAGCCCACTGGTCCTCAAGAGGTGCCACGTCTCCACACATCAGCACAACTACGCAGCGCCTCCCTCCACTCGGAACGACTATCCTGCTGCCAAGAGGCTCAAGTTGGACAGTGTCAGAGTCCTGAGACAGATCAGCAACAACCGAAAATGCACCAGCCCCAGGTCCTCGGACACCGAGGAGAATGTCAAGAGGCGAACACACAACGTCTTGGAGCGCCAGAGGACCAACCAGCTAAAACGGAGCTTTTTTGCCCTGCCTGACCAGATCCCGGAGTTGCAAAACATGAAAGGCCCCCAAGGTACTTATCCTTAAAAAAGCCACAGCATACATCCTGTCCCTCCAAGCAGAGGAGCAAAAAAGCTCATTTCTGAAGAGGACTTGTTGCGGAAACGACCAGAACAGTTGAAACACAAACTTGAACAGCTACGG1AACTCTTGTCCGTAA

[0334] TABLE 5 (mouse gene: Nfkb1; human gene NFKB1) Mouse genomicsequence (SEQ ID NO: 25) Mouse mRNA sequence (SEQ ID NO: 26) Mousecoding sequence (SEQ ID NO: 27) Human genomic sequence (SEQ ID NO: 28)Human mRNA sequence (SEQ ID NO: 29) Human coding sequence (SEQ lID NO:30) MOUSE SEQUENCE - GENOMIC (SEQ ID NO: 25)TCTTCTGAATATCATGTTTAGATTATGTAAGTATTCACCGGCTTTCTGTCACTATAAACCAATACCTGACTTGATTAATGAATAAAGAAAAAAAGGTTTAGTTGATGAGTTTTGAAGGTTCCAGTCTACCAGTCTGTTACTGAAGACGTCCACCGTGATAGTATGTCATGGCCAGAGCACCTGGCAAAGCATAAACTACCTGCTCGTCAATCAGGAAGCAAATAGAAAAGAGAACTGGTTGCGGTCCCACAACATCCTTCCAGGTCATGTCTTAGTAGAGCACTTCTCCCAGGAGAAGCACCCTGTTGGCCTTGCCGTCAACACATGAACAGCTTGGGGACTCCTACTGAGGTAACAGTACCCATTCTGCATACATTCCCTGAGATTAACTGAGACTTGATTCATGGCCCGCTGTTTTGTCTGCCTTTGTGAGTGTTCTGCTTGCAGCCCTACTAAACACAGATGGCCAATGTGGTATTCAGAGTAGTCGGCCTTTAAGAGGTTATGAGGTCATAGCACATACCCTGCCCCTGCCATGAATAGGATTTTAAAGGGGGCTGATGAAGGAGGGTTGTCCCCTCTGACTCTTCCACCTTTACTGTGTGACAATAGAGTGATTGTTTCCTCGTGACATTCCTCATTTGCGTGCTTTGACCTTGCACTTCTTGCCTCCAGAGTGATAAAAAATAAACTTATGTTTTTTATAAACTACCCAGACTCAAGTACTGTTTAACAGTACAGACATATGAAGACAGTTGGTCGTGTTTGTAGTCAGCACCGAAAGAGGAAAGTTGAAAACTTCCACTCTACTTGTGGATTTCTGTCTCTTCCACAAATGTTTAGGTCTACTACTTTGTACTTCATGTATTTTGGAGACCTATTAATAAGTGCATGCAGGTGGAGGTCATTATTTTTATAAGGGCTCAGTAGTGCATACATATAAGGTTCCAACACTCAGCATCTAGAGGCAGGAGGGTTGCTGGGAGTTTGAGCCCAGCCAGAGCTATCTATAGAGACCCTGTCATAAAACAACAAAATTATTACTGCCCATTGATGACCTGGCCCCTTTATTCTTATATATATATCCTTCTTTGCCCTTAGTAATATTCCACCCCCTGATCTTCTCTATTGGTGGTTATGATATAAACTACTTTGCTGTGTTTAGTATTTGTATTATTAGCACAGTATCCCAGGCTTCTGCTTTTAAACACTTTGCGTCTTTCATGTTAAAAATAATTCATAGGAAAAGCATTTTCTTGCGTCTTGCTTTTTCTGTACTGTTTACCATGAATGCTTTTTATAGCTGAGTTTATTTTATTTGCATTTAATATTGGACCTCTTCTTTATCCACATTTTGTCTTTCATTGTCATCTTTTAAATGAAATAAACGTAGCACTTGAAGAGTTCCATTTTATCTCCCGTCTGGTAGTTCTGTAAAACGGTGGCTTTCTGTAGTAGGACTTTCTGCATCCTGCGTCTATAGCGAGTGAAGCGCTATGTACCTAATGTGGAAGCTTTGATTTGTTCTCACCTCTCTGCTAGTGCTGGTAGACTTTTTTCCCTCCATGGGTTCAGAATACTCCATAATATATTGTGTTGTTCAATGTGTTTGTTGTACAGTAAGTTTGAACATACTGCAAACCGAAAGCCCCATGTGCCCACACCTTTATCACCAGTAGTGTTTTCCTTGTTTCTTAAAGGTCCAATTCTATCTCATTTCCCTTCACCACAAAGATCTGCTTTTAGGATGTCTTCTGTCACTTCTACGCGTTATGAATTCTCTCAGCTCTGCTTTATTAGAAAGTGTCAGTTTACCTTTATTGTCAAACCATTCTGGGACAAAGCTACCTGCTTCTTTGTGGCTTCAATGTTTTTGTTGTTCATTATAGATATCATGATGTGAAGAGTTTGCATGTTTTTCTTTTATTCAGAGTTGAGTTTTGTCCTAGTAGGCCTTACTAAGATGCATTTAAGTCGCCCTTATTTTATGATGTGTTCTTGACTCTTATAACACGGTTTTCCCCTAGACTGCTATAAAGCACACATGTTCAGAACGTTTACTGATGTCTCTTCAGCCCACGTGATTGCACCCTCAGTGTCTCTCAGCTCTGTATGGCGTCTGTAATCTTATCAGAGCATTTATAGAACAACAGTGGCTTTCACTGAGCTTTTTGGGATCTCTGTTAGGATTTCATCAGAGTAAAGGTGGGCTGATTATAGATTTTTGAGCCTTTGCACATATACCATTTCTCTGACCAATGAGATCACTGCTCTTTATTTGAACTCTGCTTCCTGTGGCCTGGATTAGAAAGTGCCCTCAGTCAGAAGGTGAGCTTGGAGTTCACTTAAACTGTGCAGCCTGTATCTCTTGTTTAGTGTCTCAGGCTATTGTGTTTCATAATTACATATGAATTTGGCAAGATCAAATAGTGGTTGATTTATAATGACTGAAATTAGATTTGTGTGGATTTTTAAAGATTTTTTTTTTCAAGACAGGGTTTCTCTGTGTAGCCCTGGCTGTCCTGGAACCCACTCTGTAGACCAGGCTGATCTTGAACTCAGATCTACCTGCCTCTGCCTCTGGAGTGCTAGGATTAAAGGCATGCTCCACCACTGCCCAGCTGTAGCATCCTATTAATGATTTTGAAAGACATTATTCCAGGGCATTTATATATTCAATATGTTGGCTAGCTAGCATTTCTCTACAGCTTTGTTTTGAAACTTTCTCATCATCCCAGAAGAGTCCCTTCAATGTGGTAAATGATGGCTCCCTTCCCAGTCTTCACTCACTCCCCTGGCCTCTGGCAAGCAATGATGTGTTCCTCTTCCTACGAATGTGCTTGTTCTTGGTATTCAATGTGAAGGGAATTGAGTATAGGTGAGCGACCCTTTCTGTCTGGTTTCAGTATAAATCATTTAGTCTACTGGTTTTGAAATACAAAATCAAAACTCCCATTGCTGGCTGTAAGGCACACCATTTAAGGAGACTGTAAATATATAATGTATGATTAAGTTGCATAGAAACAGTGAACCATAGTGCAAAACCACCAGGAAATGTTATAGACCTTATGGACTGAGGCGATAACAGTGGAAGAGAAAATACAGGTTTTATGGAAGAAGTTGATTTTGAAGTACCATGTTGTGGAATACATAATATCTAAACAGGATAGAATCTCGAGTGTGAAGAGATGTACACACTGGAAAGAAATGACATAGAGCTGTTACATGTGTCTGTGTACACATGCGTGTGTCCGTGTATGCAGTGAGCATTCACATGTGTAGAGGTCAAAGGACATTTTGGAAGCTGGTTCTTTCCTTCGAGCATGTAAGTTCCAAGTAAGGAACTTAGGTCCTTGGGCTTAGCACCAAGTGTTTTTACCTGCAGAGCCCTCTTGTTGGCCAAGCAATGCATCTTTAAATGATTGATTTCCCTATAGTAAAGTGCTTGTGTTGGATCATGGTGATAGTTGTGGTGCTTATATAATATATAATATAATATAATCATATGCTGACTAGTTGCTCTTTGGACTTCACTATGTAAAGCACCTGGCTGTGATCTGAAAGATATTTAATCAGGAAGATACCCTGCCATGGGGGTGAGCGGTAGAAAAGCTGTTTCTGTCAGAGTGACGTAATAAGGTCTGCCCTAGGGTGTGGCTATGGACATAGAAAGGAAGTGCACACACAAGAAACAGTGTGAGGAAAGAAGTGAGCGACAACAAGACTGTTCACTGCATTGGTTGGAGAAGGCTACATTTGCAAGAATGAGACAGTCAGGAGTCGGGCTTGTTGTCGAGTAGTAAACTCTAGACATTACGGTTGATGGGTTTAATGTATCATTAACTTGTTTTCTAATGGCATCGTTACCTAAACCTAACAGGGGCTCATTACCAAATACACCTTCAGAGCCTTAACAGTTCTAATCATGTACTGATGTCACGGCGGTTGCCCTCCTATCTTGGATAGCTTGCGTTTTTTCTTTTGTTTTGTTTCTTTTTGCTCTTTCCTTTTTTTAAAAAAAATTATTTATTTTTTCTTCAATTCAGAACTCAGTAGCCGATCGAGAAAACCCACTGCAAAGTCCACACCGTGACTAAGACTGTAATTAAGCTGTGATACTAAATTGCCAGGGTAATTAACCCATGCTCCACACGCCCTCTGTTCCCATAAACACTGACCAAGCTCTATCGTGTAGGCTGCTCTCTTTCCATTTACTAACCGTTCTAAATTGGCTAGCCTTTAACTGCGGCCAGATATCATGAAGAACCACATAGAAACACACATATGCCTCATTTCTTGCGACCTCTGACTGTGTGTCCTCATTTGTCTGGCTGCTCTGTGGACGTCCTCAGCTGCTCTGCCACCGAGGCCTCAGCCTGGGAAGTCTTGGCTGAGCTCTCCTGCGTTTCCACTCCACACGTGCGTTCTCATCCTCCACTGCGCTGGCCAGGCCTTTCCCTTCCAGGAAACAAAATCCAGTCATTGAACCCCTTCTTGAAAGCCATCTTCATGACTCATCTCTGCATCCTCCTGTTGGTCAGGGCCTGCCAAGGGCCTGACAACATTCAAGGGGCAGAGATGTCAATTTTATTGTCCCTGTGTTGTGAGGGATAGAAAAGGGCAGTGGCCATTCTTTTGAGCCTACTACACCTATAAGCCCTGAGTTCACACTATGCCACTCTTGTGTAGTTTTGTTTCTTTGGAAACTGACAGGGTAGGCAAACCTCTTTCTGATGGGTTGATGAAGGGCCAAAAACATCCAGGTAACATTTCAAACATGGTTTCCCTGTGATACAGACCATGGCAGGCAAACCTCTTTCTGATGGGTTGATGAAGGGCCAAAAACATCCACGTAACATTTCAAACATGCTTTCCCTGTGATACAGACCATGGCATACACAAGTATCACAAATCTCTTCCTACACCACTGTGGATGACACACACACACACTCTCTCTCTCTTTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCACACACACACACACACACATGTTTTAATTTTTAGTTTAGCTAACTGTGGCTTTTGTGAGATATTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTTTCTCTCTCTCTCTTTCTCTCTCTCCCTTCACGTTTGGATTGCCTTGTAAGTAGCTCATCTGAAATTCATGCACTGTAAGGTCCTATTCTGTTCTCTGGGTTACTCTGTAGAAGAGTTCTATGGGCTCACCAGGTACTAGATGTAGGAACAGAAAGCACACTCGGGAGAAGGCATGTTGCAGAAACGAGAGAAACATGCTGAGACTCCTAATGTGCATCTCCCCAGTCGAGACAACACAATTTGACTGGACAGTGTGTGCATCAAGGCTAAAGAGCGCTCAGGGAATATAGAGGGAGCCTCTTCCCCCTCCAGTCACCGTGACAGCATGCTACTTCGTGTGTTGGCATGCACAAAATTGGCAGAACGCCTCAAGTGTGGAGAATTCACCATTATAACAAGATTATAGTAACCAAAAAATCACTCCACATCACGTAGAAGAGGGAGTTGGCAAAGGCGGCTGGTTTAAAGCAGCTCTTTGCAATCTTCTCTAGAGGGTCTTATCTGAAACCAAACAAAAAACAACAGGAACAGCTTGAATGTTAGCAGTTATCCTGGCAGGCAGCACTCCAACCCAGCCCACCCCACCCAGCCCCCAGCACAGGTGTGTAACCCTTTAGTAGCCTACTTAATATGGCTGAAGAGATAGATGGCTTAACTAGTAAGAGTGCTTACTGCTCTTGCAGAGCACTCAGCCTGGTTCCTAACTCCCACATGATCACTGACAACCTCCTGTCACGCTGGTTCCAGGGGATCTGGCACTCCCCTCCTTGCCTCTGCCAGTACCCTTACATTTGTGGTGCACAGTCATGCTTGCAGGCAAAACACTCAAGCCACATAAAATAAAAATTAATAAAACCTTGAAAAAAAGATCCTAGCTAGCAGTTAATATCATGAGTAGACTAGCTCCAGCCAGAACTTTTGAGAGGCTTGAAGCAAAGATGTTTTTAAATGAATAATACTTCTGTCAAGAGGAAAATCACATCACCCATTACGCTAGTACAAGGGCCATAAGCTGTGCAGTTAGAGAGGCCAGCTCTAGTCTGTCAGCCTGAGCAAATGACTCATTCTCTCTGAAGCTTGGCTCTTCAGCTGGACTCTACTTTCTGGGCTCAGCATAGCAAGAGGGCAGCATACGTAAGCATTACCTCCGGTTCCTTAGTTATGTGGAAGCAGTCTGTCAAGCTTAGCTTTCCCCATACAAAGGAGAGCACTTGTCCTGAGGCCAGAGCACTCACTGGCTTCTCCTCCTCAGCGTAACTGGCACCAGGGATTAGGTAAATTGTCCCTGGGTTAATCCTGACCCTTCCAGGATCTTTGGATCACTTCTAGAAGATGCTAGGACCAGCCATCCAGTCCTGTGAGCCCAGAATACTTCAGAGAATAACTTCTAAACTCCCCCTCAGGGAAAAATACAAGTTATAGGGTAATGGCATGCAACCACTTCAGACTCAAATATGTTAGACTGTCAGTAGCTATTGGCAGAAAATTTATCTGTCTTTGCTACAGTTCTATTGCTGTGAAGAGACATCATGACCAAGGCAACTCTTCTAAAAGAAAGCCTTTAAATGGGCCTGGCGTACAATTGTAGACGTTTAGTCCATTATCATGATGGCAGAGAGCAGAGGACACAGGCAGGCACAGAATCAGGAGCTGAGAGTTCTGCATCATGGTCTGTAGGCAGAGAAAGACAGACTCTGGACTTGGGATGGGCTTTTGAAACCTCAGTGCTCCTCCTCAGTGACAGACTTCCTCTAACAAGGCCACACTTCGTAATCCTTTTAATCCTTTCAAATAGTGTCACTCCCTGGTGACTAAGCACACAAATATATGAGCCTGTGTCTTTCTCAGGACAACGAAAAGTTTATCTTGCATCTTTCTTCCTATAATTTATCATGAGTGAGCTATTAGACTGTCTGGTGAGTTAACATATGTTCTGTATCTCCCACTCACTAATAAGCTTCGCATGGATTAGCTAGCTGAGTGTTTCCCATGGGTCTGCCAGCCCATTAGCCTGACACTCCATCATGAATGGGTTTCTTCGTCAGCTCTCAGATTTGCATTTGCAGTCCGTGCATGTATTGTTCTAGGTCATTGTCACGATGCTCCTGGTGAAATAATATTGAAAATAAAAGAAGTGGGAAACCAGGTTCTGTAAATCTCAGTGTGCTAGCATGCACAGAAACATTGATTTATTTTTAAAAGAAAGCTTTTAGAAATCAGCATTACTGAAAAAAAAAAAGTCCATTGCCAGCCTTTATCATTAGTGTGACATACTCTCAGACAGGAGGACACACAGAAAGGGGGACGCTTCTGAAGAGCAGTCAGGAATAATTAGGAGTGTTGACGAATTCATACTTCATATTTTATTTAACACTCTCAGGGCATTTTAGGTTCAATCATTTAAATTTAGATTCAGCCCCCTTTTTATTCTAATACATGTCTAATGTGTATTAGATAAATTTCCATGTCACTGTACAAATCTCCCCATTGTTATAGCAATTCCATAATATTTAACTTACAGTTGTAGAACAACAATGCAAACAGTTAGATCACAGCACATCACAAACTCCTGAAAATCGACTTGCAGAATTTACGCCCTCTGAATATTTTACATGGTATACACTTTATGTGGCCATAGCCCTTACATTATGTTTTCTTCAAAAAATTCTCTATGGAAAAGAAACTTTAACATTTTATAATTTAATCTTTAGCAATTTATTGTGCGTGCAAGATACAAAACAAAAAATGTTGTGAAAAGTCTCTTTTCCCAGTATCTTTGCCCCATTGCTAACAATAACAGTACATTAAATGACACCTAAGTGACACCTGTTATGGTTACTAGAATTTTAAACCACCCTGCCACCCCACCCCCTCCCTGATTTCCAAGTGCACCTTCTAGCTGGTGTCTGACCGCCTACTTTTCATAGTGCGCATTGTGGTTCTCTTTGGATTATGGTATTTTAATGGGTTTGGAAATTTAGACACCCTTTTCCCCCAAAGAAATCGAACAGAACAGAAACAGTTGTTGGTGTTGGTCGTGTTGTTGTTGGTGGTGCTTACAGTGAGTCAGCCCTCGGCTGCCTATATCTCTGAACCTAGATGCTATATAGTTACTGACAGGAATTCTCCTGACTTTGTCCTTGATGGCATACAGCCATGCCTTTAGAATTTCTCCACTCAGTCCAGCTGCTTCACCAAGATGCCCCTGTGTCAGATTGAGTTACTAGGAAGATTGCCACAGCAATGCAGGAAACAGTTCGTTCAGCATTCATAGAATATGTCACATACTCAGGACTTGGCTGGTTTTGTTACATTGTGCTTTGTATGAAAACCACAACTCCCCGGATATTTGCTGAGACCTAGCTACATTTTCTGCGTCTCCTTATGTCGTGAGAAGATCCCTAAAGATTCCTGGTTGGGGTAGACAAATCCATAAATGAGACCCAGGCTTGTGTCTCCCTTTGTGTCTCAAGGTCCTTCCTCAAAAGCGCAAAAGGAAAGTCGCGAAAAGGCTGAGAAAGCAGGGGTACATAAGGGACTTTCCCACTCCTTTCTCATCCCCAGCTCCAAAGCTTAGTCGATATTTCAACATTTTAGGTATAAACTTGCTTTTGCAATCAATGCAAATATTACTCAGTGATTCATCCTTTCCAAGTGACTCTCGGTTTCTTTCTTTTGACATTTAATTTAAAATTAGAAATTAGCATTTATATCATGCTAGAGCTGCACTTACCTTTCAACGCCTCAGTAATCGCCAAGGCTTTATGCGTCAAQATTCTAAGGCACCCGAGTCTTCCTTGAGCTTCTGTAGTACCTGACGGAGTTAGTTTTTAGCCACATATAAATCTAGAAACCGTAGGAGACGGTGCCATGATGACAAGGTGCCCAGTATGGTCGTTTGTCAGACATTTAAAGTGGAGCCGTCTTCATTAGGCCCTCATGTAGGGAATGGACCAGGAGGATACCCTTACGTCTGTGAAGTGCGGTTGGAGTTCAATCTTCCAAGTTGGAGTGAGACTTCTTTATGTTAAATTCCCCCACTCAAACTTCTACAAATCATCCAATTTTAAAGAATGATTTTTAAGATGATAATATATTATATCATTTCCCCTTCCCCTGCCTCCAAGTTCTTTCATCTACCTCTCTCTCAAAACTTCATGACCTCTTTTTCTTTAATTGATGTATCTTTTTCTAAGTACAAAAAAAAAAAAATCAATCTGCTCCATCCATCTAATGTTACTTGTATGAATGTTTCCATTGGCATTGAGTAACCAATCAGTGTACATTTTTGGGAAACACAATTTCTCATGCTCTCAGCTTTCCCTATGTGCCTGTAGTTCTTAGTCTAGGGTTGAGACCTCCTGAGCAATCTCCCTTTCACATTGCCTGTCTGTTGGTCCCATCCTTGTTCAGGTACACACAGAATCAATGACATAAAGGTACTAAGTGGGTTTGGACAGTTTAATAAGGCAATAATGTCACCTCCACCTTAGAAGATTGTCTTTGGATTGTTAGGAAAGAATATCATCACCCAGGTTAATGGAAAACCTAGAGTCATAAGGATAGTGTAAAACATTGTTTGTGGAAATTAATTACTATCCAAAGTCACATACCAGACAGTGCCAGAACCCTGCTATTTTCAATGATGTCATACCCCTTTACTGCATCAAGTCAAAATTCCCCTGTTTTAACTTTTTTGTCTGAATAAATATGTTTAQTTGCAGCTGCTTAGACACTTTTGTTTTGTTTGTTTCATTTTGTTTTAAGACAAGAATCTTACTGTGTAGCCCTCGAACTCACCATGTAGACCAGGCTAACCTCTACCACAAAGACATCTACTTGCCTCTCCCTCCCAATGCTGAGATTAAGGCGTGTGCCACTACACCCAGCTCGTCTTTTCTTTTTAAGTATGTATCAATAAATTGTGTGTTTGTGTGTGCCTGCATAAGTTTATGTATACTTTATGTGTGCAGGTACCCTCACAGCCCAGAAGAGGCTGTCAGAGCCCTTGTAACTGGAGTTTGACGGTCGTGAGCTGCGCATGTAAGTACTGGGAACTGAATCAGGGCCTTCTGCACGCTTAACTGTTGAGCCAGCTCTCCAGCTTGTGTTTAAACATTTTCAAGTGTTTCTTGTTTTAAACAACCCCACTTCCTTGCACACACCTTTGTGAAGTTGTCCCAAAGGACTTAGACCTCCTACTTTTCCTTTAGTTGCTCCTCGCCCTCCTCCATCTGCCCCTGGCAGTTCTCCAGAGCCTCCCGTCCATCCCATTAGTCACGTCCTGTTATAGCACACACCCTTTCACTGGAAATGAAGCCTCAAGTTATGCCAATGTCCCGAGATGTTTTTATTAGTGTAACATAGCCTTTTGATGGAGGCTACACAGTACATTGGATTGAAAACTAACTAGCCTCCATTCTTCCATCAGCCTATCTTCAAGCTCCAAGGTGGCCACAACAGCCCCATCCTTTGATACACAGTCTGTTCCCTCATGTCCTAGAAGCCACGCCTTTTCTACATTTGGGTTTTATTCAGCATCCAACGCAGTTTTTTAAAAAAAGATTTATTTATTTATTTAATGTATGTGAGTACACTGTAGCTGTACAGATGCTTGTGAGCCTTCATGTAGTTGTTGGCAATTGAATTTTTACGACCTCTCCTCACTCTGGTCGGCCCTGCTCACTCCAGCCCAAAGATTTACTATTATACATAAGTACACTGTAGCTCACTTCAGACGCATCAGAACACCCCATCACATCTCATTACAGGTGCGTGTCACCCACCATGTGGTTGCTCCCATTTCAACTCAGGGCCTTCAGAAGAGCAGTCAGTGCTCTTACGCGATGAGCCATCTCACCAGCCCAGAATGTGATTTTCACGTGCACATACATGGTTCTATCTGTTTATCACGGTCTCTGGCTGCCTGAAGGCCGCTCAGGCTGCTTATATTAATAGCTTGCTAACTTCAGTAAGTTTGAGACTTTCAGGTTTGATGTTTTCACTGGTTATTTTTTTAGTGCACTCTTTAGAGTTACAGAATTTTCATTGCACTTTGACAAAGGCAGAATCACTCTCACCAGTCCTCACAAGAGGGCAGGGGGTGTCGTTCTATGCCCACTCAAGTCTTATGTAAAATGGTATCAGCACTTCCTCAGCCTCTCAACCGAGTCTAGACAGTCCTAGGACCATCTCAGAGTTCATGACAAAAAAAATGCACAAAGTAGAAGTGGCCACAGGGTTCCATCTGGACCTGATTTTTACCCAGAGGTACCACCAGCTGTATCAAACCGAGGACCCTGAGCTTAGCCAAAGGGTTTAGATCCCGTGCTCTCCCTACAATCAGAGGTACATGCCAAGGACGTACAGCACGCATGATGCCCTCCTACACACCTCTTTTTTGCACACATTTGTGGTCCCTGTAGAAATACAGCCTAGCCCTGCATATGTGCCAGAGTTGTAGGATCTTTAAGATTCACTCCAGTGCTACAGCTTTCATTTCTTGTTCTCTTTTCTACAGCTTCACCATGGCAGACGATGATCCCTACCGAACTGCGCAACTAAGTCCTCAGCTCACTACCAACTTTGTTTCAACGCGTTCTTATCCCAAACACACAGAGGCAACGCTAGTAACTCACTATCAAGCAAACCCTAAATTAGTAAACACTACTCTTAATTTATTTTCAGTTTTTCTGTTCTTCCAGAGTTCGAGAGGGCCCTTTCTTATGTATTTTTGCATAAAACCGTATATACTACATGCCAGAAAGTAGCCACTGAGTCAGTTGTGGTGTTGAAGGTCTGACCCCAGTATTTCATATGGTGACTGGTATATTAAAAAAATTGCTATTCAGTGAGATTTCTAGGGCTGCTATTAACATCGCTACAAACCTGGTGACTTGACACAATAGAAGTGTATCCTTTCATAGGTCTGGAGGCAAGAACTCTCAATTTGGGGCTGCCACAATAGTTCCCACCTCCTACCACTGCTGGGTGTGTTTAGAGATCCTTGGCATCACACCAGCCACACTCTGTTGTTGTGTGGCTTTCCTCCACGTCTTCACACATACCATCTCCTCTGTCTTAAAAACACATCACTTTTTGGATGTAGGATCCATCTCTGTCTAGTGTGAATTCATCTTAACATATATAAAGCCAAAGGCTGCCCTGTCCAAATAAGTCACATGAAGGAGCAGCACTTATGAATTCTGAATATATTTTTTTTCAAAGGTACTGTAGTTAAGCCCACTGCAGTCTGTGGGACTCAGTGTGCTTTGACAGCGGAGCAGTGTTTATCATCACGTCATTGTCGCTGTCATCATAGGTGTGACAGCAGCCATGACACAGACTGACACGAGGATATCTGTATCTTCACTTTCCTTCTACTTTTTTCTCTTAAAAAATCTAAACCCATAGAAGTGTTAGACAGTCTGATGATACTTCCATTTCTTTCTCTTCTCCCCATAGAGAATATAGCCACCATAGAACTGATTCTTGAAAGCAGTTTCTAGCTGCTAGCATGATTACAGTGGCAATATTAAAAGTGGACTCTAATGGTCTATTAAATTATTTAAAATACTGGTATCTCTTTGCTCCTCAGCTATCTACTGAGACTTTATAGAAGACTTTATGCCCACAACATTAGCATCCTAGAGACGAAGGCACAGGTGATATGCTCACTGGGCTCAGGACTGCATCCCGGCTGCAGTAACGGAACCACACTTTACACAGTCTGTGGATGTTGCCATGGTTCACTGAGAGACAGAAGCAGTTGGAGGGATTGCTGTGTGTTCCTTTAGGGAAAGAGCAGGTTAAGGATGACTTTGCAAAGGAGGACTAAGCTGAGCTTTGAAAGCTACAACCAGTGCAGGGGCACTATTTACCAAGGTAGCCCTGCCACAACATTCATTACTACTTCACATTTAAATTTTGGTGGTAAACACCCGAGACTACCATTTCCCAAATTTATGCTCGCAAAGAGTCAGCCAAAAATAAAACTGAAAATGAAATATTTGGGGGAGACCTGGTGTTTCTATAGTCACACAGCCCCACACCCCCAGTCAGAGCTGCCATGGCCTGCACCGTAGTGACAGCTGCAGTGGCCTCAGACCTGCAGTCAGAGCCGCAGTGGCCCTCTTCTTCTCACCCAGCGCGCGGAGTGAGCATGCACCATCCCCTCCTGACCATGTTATAAAGATGGTGGTACTGGGTAAACCTAAGGATGTTTTCTTTTATGGCAGCATAAAAGACACCTGGCAACCATACGCTCAAACCCCTTGTTTAACCTTTCACTTTTAATGGGCCTCCTCTAACACAGGCCAGCCCTCACCACCATGAGAGCTGTCTGCTTCGTTTCAAACCATGCTTTTCTGTCTGTACACAGGAAATCTTAGCAACCAGAGATGGTCTTTTATGCCACAAAAGACTAAGACCTGCCAAGGACAGTCATTTTGAAACTGTCTCATGTGGGCAGCAGTTCTGAGCTCATTAGCAGGGTGGCCATGTTCTGATAGTTCAGTTGTGGGGGAAGGGGAGGCCCTTGGAGGCTTTTAACTTTTTGTCTTTGGGTTGGTTTTTTCTTCCTGTCTTAAGCTTTAAGTCTATCTCTTCTAAAGTTTGCGATTTTTGACGCACGTGTCCTCCGTGTTTTAGCCACACTGGAGTTTGTTCTCCACCTGTCACCAAGCAAACACCACATGCCGCCTTCAACAGGACGTCTGTCTTAGTGGGCTTCTCCCCCAGCCAGATCACTGCAGACAGAGGCGGAACCACAGCAAAGGACTTCTTTGTGAGGTCGTTCTCTTTGCTCAGAGATGCAGGCCTGGAGCTTATTATAAAACCTAGTTTCCCATTCAGTGTGTCTTTCATGGTTAATAGCGAATGGCACAGATGCGCTTTCCTTTTAACGATTGAAATATAACACACTCTTTGCTCCTCAGTTGAAAATTTGCATCCCTCAAAAGTGGATTTGAAGTGACTCGCATTTAAACATCACATTTTAGGGGCCACTAAGATTTTTCAGACAGCAAAGTGCTTACTAAGTTAGCTTGACTTTGACTTCCTCCACTACCCACACATAAGCACACTCATCTTACACACACACACATATCCATCTCATGTTAAACACACATACTACACATACATATGCACTCTTACACTATGCACACATACACACCTTACACAAACATATATCTCCATACACTCAAACACACACACTCACATACTCCCACTACACATACATACACTTTCACACTATACACACATACATGCACACACACTCACACTACATATACATACATACTTTCATACTACACATGCATACACACATACTACGCATACATATACACTCTCATACCACACACACATACACTCACACTACACACACACATACACATTCTCACACTACACACACAAATGTAATAAACATGCAAGCATTACTCTTCTTATTCTTGATTTAACTAGACATAGTAGGATTTGAGGTACCCAAGAATATCTAGTGATTTACTAATAAGGACAAAAAATCCCAAAAACCAAAAACCAAAAAAAAAAAGAAACAAAGAAAAAAACCGTCTAGCTTGCAAGCTCACCAGAGAAAGTAAAAGAAATAATTTGGTTTCTATGTTGTCCATAAACATTTCAACAAGTCACTTCTGGTGAGTGAGACAGATAGTAAGCTCACACATACAAATGTGATTTTCTAAATGAGCTAACTCGGAAAATTCCTTTTGGAGTAATTATTAGTCATAACTTACCAAGGTAGAGCTTAATTCTATCAAAACGTTATATGTTCACTTTTTCAGTTTTCTTAGTTGTGTGTTGTTTCTGTAACAAGTTACCATAGTATTTGAAACAACACAAATATCTTCTAAAGATTAGAATAAAAATGTCAGAGTCGAGGCATCAACAGGGCTACACTCCTAGCAGCGTTTATTTCTTGTCTTCCAAGCTCTAGGGGCTGCCTGTAAGTCCTGCTATCATCCCCCAGTCCTGCCTCTGTAGGCCTGGGTGAGTCCTGCTACCATCCCTCACTCCTCCTTCTGTAGGCACACTGCACTTTGATTTCTCACTCTCCTAAGTAGCTCACTTGGATATTCCAGGATAATCCTGTCATTTAATTGTCCTACATTGATGGCACATGCAATATATCTTTTGCCACAGAAAGCATAGGTTCTCGGGAATAGGAAGGTTCTGTGGAGTAGCATGTAGACATCTTTAGAGCCATTGTTCAGTGTGCCTTCATCTACTAGATTCAGGTATTTATATTGTAATAGAAAATAGAGCTGGGCAGTGGTGGCACATGCCTTTAATCTCAGCACTTGGGAGGTAGAGGCAGGTGGATTTCTGAGTTCGAGGCCAGCCTGGTCTACAAAGTGAGTTCCAGGACAGCCAGGGCTACACAGAGAGACCCTGTCTCGATAAAAAAAAAAGAAAGAAACAAACAAACAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAGACGACGACCACGACGACCACGACGACGAAAAGAAAAAGAAAATAGAGGCGGGAGAAAGTGAGCCCTCTGCTCCATCATGTTCTCAGTTGTATTGCCAGTCATTTTGTAAGTTGTGTAACTCCTGCCTGTAATTCTTTCAAGGCCTTGAAGTTCTGTAGCTCAGTAAGTAATCTATTTATCATCAGAACAGAAGCATACATATCTAAGATCATGTCCACGTATGTCCTGTCTGTCTGTACGTGTACATTCACAAGTGTGTGGAGGCTCAAGGTGGCTCCCCATCTTTGATTTTGAGAAACGGTGTCTAACCTAACCTACAGCTCCTGGATTCAGCTAAGACCTCCAGCCAGCAAATCTTCATGTCTCCACCTTCCTGTAGCTGGGACTGCAGACAACTGCCGCCAGCCCAGCTTTTCACTGGGGTACTGGGGCTCTGGACTCAGGTTCTTGTGCTCTACAGCAAGCACCTTATCAACTCGGCCATCTCCCCACCCTCTGCGATGTAATGAACTCAACTTCCTAAGAGCGTGCGAGATTCACATCACTTACTCTACACATTTTTCTGAAGGGTCCAGCATGCCTGAAGCTCTCTTGGCTCCCAAGATGCACAGCTTGCGGGATCCACCAGGCCCTTGTCTTTAGGGACCCCATAGCCATTATTCTCCTCAAATTTCTTTGTTACATAACTTACACACACAGCCCCCTAAGAACGTCCCAGAAAGGCACGTTAAAATTTTGATTTCACGAATCCTATTTTTGCGTTTTTATTTCTAGTTTTCAATCATCTAATTAGTTTTCTGGCTTTGTGTATTACTCCAAGAAGAGAAATTAAAATATTTGTATTTTCTTCTTTACAGATCTTTCATTTGAACACTGCTTTGACTCACTCAATATTTAATGCAGAATTATATTCACCACAAATACCACTGTCAACACGTAAGAAAAACACCCCCTTTTCCTGTTGTTTTGCTTTCCCTTAAAAATATTTGGGCTCAGCACTCACGGAGATGTGGATCAACCAAACTAAGTATATATGAAATTACTATAAGGAAATCTGTTGCTTTGTCGCTCCTTGGGACCTACCCCAGCCCCTCTGCAACAGCCACAAGCACTTTTAACCACAGAACCATCTCTTTAGCCACAACAGTCTCTTTTAAAATTCAACAATATTCATACGAAGGAAGTCGTGATCCGTCTTTTAAAACCACCCTTTCAGTATGCTTTCTGCAAATCTGTCTCACAAAAATGCTCCCGCGTGCGCGCACACACATCCTTTTAGCAAGTGTGGTTTCTGGTCTCTGTTAGAATACCCTGAAGCCCTGTCTTCACCCCCTGTAACCACTTTCCTCTTCTCCGTATCTCATTACCCATTACTGCTCCTTTTTCCTTTACCGCAGCTCACAGAGAGCCAGTCTTAGCCCCTCAGTTCTGTATCTGAGGGCCAGTCTTGTCAGCCAGGACACGAGGCTCTGGCGAAACAGTAGGAAAGTAACCTTTATATTCTGACCAGACCAAGCGTACAGAACTAATGCTCCTGACATGACTCCTAATTAACGAACCCACAAACTGTTTAACCTCCCTTTATGCTATAGCGCACGGCCTTCCTTTAGACTCATTATTCACTCGCATGTGTGTACCCTTGGCCTCATGGCTCTTTTGCTGCTTTGATCACCTGTTCCAGCTAACCCGTCTTCAGCAGCCACTTGTTAGTTGGTGGACATGCGTATGGAAGTGATTGTCCATTACTGAGGTGCACAGCACGTCCTTTGTCTGCTCCGGATTTCTGTGTCTCCTGATGTAGTTTTTATCATTCTCATTTAAAATCACTATGGTTTTGCCAGCGCCTGCCTTACGGAAAGTTTTCTACAGACGTGGGAGGAAGGAGAGTTACTATGTCACCCTCCTCACTGGTGCCCAGAAGTTACATCACCCAGCCCTGTCTGTCCTTACCCCAAATAACCACCACAGTTTATCTGTAATCTTAAGCTGTCCAACACGCTCTAGGTCCCCTTCTTGTCACCAAGTAAATGCAGGGGAGGCAACCGTGTTTCCTCTCAACTTCTAAACTCTGAGACCCCAACAGCTTCCTTTAGCATTTCTGCTTTATTGAAAATGTTGCAGACTCGGTTCTGCCCTCAGGGAAAGCACAGGTTTCTAGAAAATGCCTCTAATTAGTTAGAATACTAAACAGCATCCTGCAGGCAGATGATATTCTAATGTGTTCTCCTTTTCCTTTGGTTTATGCACTTACAAATAAAGTTATCCAAAGAATCATCTCAGAAAGTCGTTGGTGTTCATATCATTGCGCTTCGGGAATCTTCTTTTCCATACTGTTAGAGAATCCTTCAGAATTCCATGCAACATCCATTCTTTTCCTGTTGTAATCGCTCCTTGCTTCCACTACCTCTCCGGCTCTGTTTCAGTGCGTTGTCCTGTTTTTATAGTCCAAGATGGATGGGACATTTTGTTCAGATTTTAAAGGACTAGAAAGGCTATCTGTCACAGTGTTTGCTTGTAATTTTCATGTGGATTTTTTTTCAATCTTCTCAACTTCTTAAAATCTCAACGTATTACTATTTCTAACCCTGTGTTGGGAACTCTCTAACAAGGGACAGCTGATAGGTCTGTGTCATTTTGCTGTGATTTAATTTTCTTTTTACAATGCAACATCATTTTTTTTCTGGCACAGAAATGTAGCCAACAGAATATTAGCCTTAAAACAAGTATCTGTGTATCAGCTCCAGTGTTCTACTTCTCTTACCCTTGGGTGTGCTCTTCTAAGGGTAATGATTGCCCCCTCTCCGCATGGAACTTCACATATGTAACGAAAACCTAAAACCAATCCTGTGAGTGTTTCAGACGGGCTGTTAAGAAGGAACAGACTTGGAGCCTAACACGAGGATGTCTCCTCTGCCTCCATATTTCAGCAGCATCTTATCCAAATGCTACCACCTTCCTGGCCTGGCTTCTCAGTAGGCTCTTTTGGATGCCTAGAGGAAATGTATATTTTTAATATTGTTATACAAGCTGTCTGATATGCCTAGCATGAAATCTTTTTCTAATCAGTTTTATTTCCTCATAAAAQTTAAATTCGAGCAATTTTCTTTTTCAAATTTAAAGTTAACAGTTACCTTTCTAAAAGTTTAAAGTGTCAAGAGATGAATCCCATGAGACAGAAGAAGGTAATTTGCTACATTACTGACCCCAGTAACCACCCATCTGTCTTTCTTATTTGGCTTCAAATTAGGTTTCCAATTGCTTTCCTGGTACAGTGTTTACGCTTCCGTGTTATCTGATCAGTCATAATATTGAGAAGGTAAAATCTATTCTCTTTGAAGTTACAGTTTATTAAAAATTACAACCTGAACTTTTATCTCACCTCAAATTTACATATGCAAAATAAGGCTTAAGCTTCAGCCGAGAAAGTGAATTTTCAAATGACCACAGAAGTGTTCTTCTAGACTGTCTTCAGCTTCAAGTCTTAATTTTCACTCAAACAACTATAAAATGTCGAATATGTTTGTGTATTACACAGCTATTGGTTATCATACTGGGACATAGAAGCCATCTGACCCCCTTATGGAATTTTTTATCATAACATTTATATTTATTTATTTTGAAATTTCAAGTCACATATCATTGGTATATAAATTGAGCCTTTAGGTCCTTTTCATAGTAATTAATTGGCATGCATTTATCTTCAATTACATTATTTTTGGTATTTTATCATAACTCTGGGCTGTTTTAGAACAGAGTTCTTATGAGCACACACTGTTAGATACTTTATTATATCTGCATCAAAAGCTGTGAGTAAGATGCCAGGGTAGTGGTCCATGCTTTTAATCCCAGCACTTGCCAACAAAATCTCTCTCAGTTTGAGGCCAACTTTGTCTACATAGTGAGCTCCAGGCGAGCCAAGGATACATGGTGAGTCTCTGTCTAACAAAACAAAACAAGCCATGGAGAAGCAAGAAAAGTTCTTCAGGTCTCACAGAGGGCAAGGAAGAAGCCAGTTAGGCAACAGTGGCTGTCCCTTGGCTTGAAGTAAGGGAAAGACTACATTTCAGGAGCAGTGTTAGGAGAGGCAGGTGGCCCAGGATCTCCCTTCTGTGGGTTTCTAGCTTCAGTTCTTCATTTACTCCTGGGCAGTTCTCTTTGAGGCAGGAAAGTAGTCTGCAGGTGAAGGCCACCTGACACCACAGCACTCAGAGGTGCTCCCTGCACTCAGCTGTATTGTGCCCTAAATGTTTGTTGACACATGAGTCTGAGGACGGCTCCCATCACAATCTCTGTCAGCATTCAGACCTTTTGTTCAGTGCCAGTGGTGTACCATTACCATTCAGAAAAAGCCACTTATTTACCGTTAGTCACTTAAACTATAAAACTANNNNNNNNNNNNNNNNNNNNATCAGACACTCTCATCTGGCTTCCTTGCCCACTAAGCAAAGCACTTATGAGCAAAAAATAAATATTTTTTAAAACATTTATTTAATATTTCAAATGATAACACAGATCAGTAGAACACACTTCACCTATAAAAATTGATTTCAAATCTCTCTTTAAAGCATAACTTCAGCATTTGTCTTGCTTTGTATTTCATACAAGATTCCAGAAGTCTCACAGTTTTCTTTTGGTTTTCTTGTGTTTTCCTTGTTTTTAACAGATGGCCCATACCTTCAAATATTAGAGCAACCAAAACACCTAACCCTAAAGGGGTCGGGTGTTTGGTAATATTACATCTCATGGTAAGGCTCGGTCTCTGAGTAATAGTTAAATCTGATGACACAGGTAAGGGTTTTATCTGAATAATCGGCAGCCTGCCGTGTTATGCAATAACTTCCTGTGTCTACATTTTTCTTACAAATCCCTTTGAAACATCAGTTAATTATAAATCCTTGGTAGTCTGTCCTTTTTCCAGCTTAGCTCATCAGCTGCTTCCAGGGAAAGCACTAAAGAGTCTCATTCATGAAGAAATACTCACACACACACAGCTTCACACCCACTCTGACCCTCTATTGCTCATGGCCATGCCCACAGCGTACCCCTCCTGCCTTCATAAGCTCTGGCCTTTTCTGTGCATAGAATGTGTAGCTTAAGGCAGTAAACGCACTGGGAGACATTAGAGTGGACTGGGAGATCTCCCCTCCACCCCTCTGCCTTTAATCCCAGCCTTTTTGAAGCAAGGAGAGGATTTTTTTGTTTCGTTGTTGTTGTTGTTTTTGTTTGTCTTTTTGTCTGGCTCTTTCGCTTTCTACTAAATATTGTGTTCACCAGCTGAAGATTAAAATAGCCTCAAAACTGCAAATATGCTCATTACAAGTTGCATGGCTCTAGTACTGTAAGAGAGAAGAGAATCTTCAATATCTGCCGACAGAACATTTCAGTCATTATGGGATGGAAGTTATGGTATAGCCTCCCACAGAGTGAGAACCAAGTCACTAGATCTCTGCGTGGATATGCTCATCACAGCCGTGGCGCTGAAGGACTGTATACCTCGCCTACCGAGTTGTGTCACCCAATGTCTTTTCTAGGCTGTTCCTTCTTGTAACTCAGGAGAGTGGGTTAACACATTGTGTTGTATGACACTCAATGCTAAGAAGTGAATGCTGACAGCATTCGGTGCTGTGCTGTAGAATTCTCATGTGGTCACCTGTTAAATAGGAGAAACATCTTAGGGATGTCCATGCTACTTTGTAAAGCTGAAATCAGATGGAAATGTTAATTATAAAGACAGCAATGTCACATCGAACTTTGCGGCATTGTTTCGTTCCTTATAGGCGGCCTCTTAACACACACACACACACACACACACACACACACACACACACACACGCACACACACATACTTATACACATGTACACCCTCCCTGGCCTGCAGATAACACCTGCCCTTGCTTTATCTCCACGTCCATCTTTGTAAAGATGATTTCTCACATAAAGTCGCTGTTCTCGGAGCTCTTCAGTAGAGTTGTGTTCTGTGAAATTCTGCCCAGTAATCTGGAATCCTGGAAAATGTCCTAGCCTGGAAGATTTGCTCAATTCATAAAACTGATGAGTCCAAAATGTACCTACACATCAAATAGATTTTTCAGATCCTTTAGAAAATTTTAAATAATTTATTTAATTTTATTTTGTGCGCATTGGTGTGATGGCGTCACACCCCTTGCAACTGCAATTACAGACAGTTCTGAGCTATGACGTGGGTGCTGCGAATTGACCGCAGGTTCCTTGGGAGAGCGGACAGTGCTCTGCTGAAACATTTCTCTAGCTCCCCTTTTTAACAATATTAAAATTGCATTGATTTATTTTTTAATGTGTTGCTCTCTTTGCCCCCACCCCGTGTGTGTGTGTGTGTGTGTGTGTGTGTTATTATGAACCCCAAAGTCATAGGTATTTATGATGTGTTTGAACAGCTAGTATAGTTCCAGAATTTAAAATTTAATTCATTTTCTGTGAATATATAAAATCATATATGTATAAAACATCATGTTTGATTGCCAGTCCGATTTTATTTTGGTATCTGGCTTTAGTGAAAGTAAGAAGGTTGTATGTAAGCCAGGCTTTTTCACTCCATGTATGGAGTCTCTCTGAGGTTAATGACTCATTTGAAGTAAATGGCGTTCCTGAGATGAACAGCGATAGATGGTGAACGTTTAATTTCAGAATACTAGAATTAGAAATGTGTCCAGAGCGTGCATTTTAAGACTTCCTAATTTTAGGTTGTTATTTAATTTAAAACATTAGTTTATTTCTGAGTCAAAAAATGTCTGTAGTCATTGCTGGCTTCAAACTGGTGCCAGTTTTCCTACCTCCCCTCTCCAACTGATAACATGACAGCTCTGACCCACCATGCCCAGCTCAAAGGCATCGATGCTCCAGCCGAACAGCGCAATACACATTACAACCTTCAGAATAAATGCTGCCTTGGATAGGACGTTCAATATTCTTATTCGACCGACAATAATACACACTCTCACACCCTGTCCAATAAATCATGCTGGCTACAGGCTTAAACGTCACTCCCCATAAGGTATGAGAGGTACAGGATACAGATTTTTCCAATGCCACAAAGAAATTTTGTAATTAAAGATAAGGAACACTATGTTAAGTTTTTGAQTTAGAAATCTTCTTTTTCTTCGAGGCCTTTTCGGCACAGATGATCAAAATCAACCAAACCACAGACTACATGTCTTTAGACTGTCCAGTTCCGTGGCATGTTTCTCACTGTTAACTGTTTATTCATGTTGTGTTGTGTTGTGTTGTGCTGTGTGAGTTTTCTACTGCTTTCTTTGGAGGCAGGGTCTCAGCAGTGTAGCCTTGGCTCGCCCCAAACTCACACAGCTCCATTTACGTGCCTCTGCCTCACAAGCACTGGGGTAAGATGTGTGGCAGTTATAATCTGAAGGTGTGTTTGAATTTTCTCAGTTAAGTGGATCCCCATCCTAACGGCAGCCCATTTGGGGCTCTTCGTGTTATACATGCTATTATTGTATAGTTTCGGGGTGATTGAGTTCAAGCGTTATCCAGACTCCATCCCAGTAATATTAATTTTTACAAACTTTATGATCTTATTCCTTGAAGTGCTCACAAGACTGCTAGACTCACACTCTCGTAGCATACAGCATGTCTGTAACACAGATAACACTTAATCCTCCAGAGACTTGAGAAGAAGCACCNAAGAGAAGGGGGATGTGGGGGGGGAGCACCCTCTCAGTCGAGGAGGAGGAGGAATGGCCTCACGAACTTCCCGGGGTGATGTAAATAAATAAAATAATTCTTAAAAAGACACCTTTATGGTCTGTCATCACAGCAGATAACGAACTCCTTTAAGTAATTAGCATAACTTTTACTCATGCCACAGCGGAGAGCTTAAGCACCAGCCATTGGTAACGAGAGGCTCCAGTTGAATAAAGTGCTAACGTATATCCAAAGGCTTAAACTCTTCATCACTCCTGTGTTGAAGGTGGGTGCCTGGCTTCTCCGCCACTGCTCACTGCATCATTTTCATAGTGGCTGTTAGAAACCATTTCTCCGTCTGCAGAGTTCTCTTCCACAGTTTTGCATGTTTAGAGACGTGTGTGTACATCTGTCATTCTTCCGTTCAGTAAATACCCCTCTGTTCACCTCTGCAGAGGGGATTTCGATTCCGCTATGTGTGTGAAGCCCCATCACACGGAGGGCTTCCGGGAGCCTCTAGTGAGAAGAACAAGAAATCCTACCCACAGGTCAAAGTAAGTTTGAAACCTCTGCTCTCACTCCCCACGAGCAAAGCCAAAACGTTCAAGTGAATGTGACTGGGATGTTCCTTTGCCCCTCAGCGGGAGTGTTTACATGGTTCTTAGAATTTTTAAATAGAAATTCACCTCATGAAAATGACGAATCGTCAAAACACCATTAACATCTCCATTTAAGTGAGATGGTTCCAACATCAACTAAGAAAAACTTAACTACCTCTCCAGTGATCTTAAAGCTGTCTTTTCATCTTAAAGTATTTTTAAATATTCTCTGATGTTTTAGTAAAACTTGGAGCCAGGTGTCATAGTCCATACCTGTAGTCACTGGACTTAAGAGGCTAGCAACAGCACTGTTAGATATCCCAAGCTAGCCTGAGCTACATAGCATGCTTGAGCTCAGCCTGGGCTAGGTGAGACCCTTATCTCGTAAGAAAACGAAGAAAATAAAAAATGTCTTTGAGGCAAATTTCAAATACTCCCTTTATACAGATTTCATGACAAGACCCTTCACACAATATATCGGCTATGGAGTATATTAATTATTTAAGATCATAAGTTCAGACCCAAGTGATGGAATAAACAGGTTGTAAGCAGGCTTATCTCACTGACCAAACATATAAATACACAAATACCACTAGCATCTACTTCACAACGTGTTTTAGAGTTTCAATGAGGAAATATGCTTAAGTTCTCTGTAGAGACCCTGAGAGAAACCGTGTGCAGCTACCATGAATGAGTTCTGTAGCATGGGGGGCAGAGGGGTGGGGGAAGCTTCACTGTCTTTACCTTGGGGTGTCGGGTGTACCTTCGCTGCTCTTCGCTTTTTACGTTGTTGATCTAGTTGAGACTACCTTCCTCTAGTTCAGAGTTTCTACTTTCCTAATCCAGTGTTGTGTTTCAGAGACTGACAGTGATTTTCCAAGGAAACAGTTAAAAACTTTCGACTGGTTTAAAACGTTTTATTTATTTGGTAATCTGGGCTTACACTAAATGTTACCAGCAGTAAACGTTATGGCACTCCAGCCTCTGTCTTTCTGCTGGCTTGAGATCTCAGACGCTCTTGCCCTCAGCTGAGCTGACACTGGGGAAGTTATCTTCAGTTTTCCCTCCTAGGTTGCTTGTCCCCCTTTTAATGTTGTACTTCCAGGCTCAGGCCTTCCAGGTTCTTGCCCTCTGTCTAAGACAAAAGAGCCATACCATCCTTTATCTTTCCAGTGAAAAAAATGTGAAAAAGCCATACCATCCTTTATCTTTCCAGTGAAACTCAGCTCCTGGCTTGGGTCCTGAGAGTCACATTTTCATTTTAAGCCTCCCAGCTCTAGTTGTGGAATGAGCCGTTTTTTTTTTCTCAGTAAAGGTAACTGAACGTGGAAGTGCAGTGGCTTTAGTCCACAGAACGCCACAGTTATATTAGACAGTGTTTTTCAGAGAAGTCGAACCAGGTCGGTGAAGACAGGGAGATAGTTAGATGGTTGACTGAGCGATAGCGGAGGAGATGAGAGTAATCGGCCTCAGCTGTGACGATTATGAACCACACCAAGACCCACTCTGCAGCGTCTGTAAAATGTGCGCAGGGACACTGCTAGGATTCCAGCACAGAAGCCTGGGCGCCCTGTAACCAAGGGGACTCTTCACTAAATCTGGGCGTGGCTATGCTTTTCCTCTAAAGGCAGGAGAGGTTGGACTGCTGATGCCCTGGAGGGGCAAGAAATGAAGAGTGTCCTCCCTCCCATTCAGGTGGGGCAGTAGCCGGAGGGAGGGAAGGAGAGGATTCTCTGGTGTTTTGGTCCAGCAGGTCTTCTAGCTGAAGGGAAGGTCTTCCATCAGTCCAGCAAACTTTCCAGTGTCCTCTGGAAACGTGCACACAGCTAGGAACCAAATCCTTTATCAGCTTTCAGCATCTGCCCAGTGTAGTCGACTGCACACCGGAAACTTCCCTCAGGACAGTCTGTGGCTTCCAGTCCTGCAGAGGCCAGGCAAGGAATGCAGAGCAGAGCACCGGCCAAGAAAACGGTTATTCCACACCCCTGGTGGTCCTCGTGTCTCCCATCTGTTCCCTCCTGTAGCCTTATTAACACTGAGGAGCTCAGGCTGAGGTTAACTGGCCCTCTTCAAAGGTGCTGGGCTTCTTTCTCCTGCAGCTCACTCGCCCTCCCATGTGAGCGTGTGCAGCTGAGGGGCCAGGGGCCAGGGGCTGAAGAACAAGTCAAGAAGGACTGATAAATCAAGTCAGGGAGGATGAGCATTCTCAACAGCAAAGAAGAAATGGGGGCAGAAGTCATCAGGGGTCAGATCTAGAATTTCCTACCTGTGTGTGTCCTGTACAAATATTGTGTGCAATTATGTGTCCTTATCTGCACCAGGGTCACTGAACATCCCTTGTCAGCACTGATACTGATCATAACTACTTAAGAACCGATGTTAGGAGAAAAAAGTAGGGTTTTTTTCTCTATTGGCCTTCTACCAAAAAAAAAAGAAAGAAAATGTACATTGTGTTCTATTTATGAACTCTTTCCTTCTGAGGCACTAGAATTCTGTGCTCTCCCATGCATGAAACATCGCAGTCTCTCTACAAACAGGCTTCCAGGGGTATCATGGCTTACTGCATACCCACCCATAATTCATCGTAGAGGTGGGTCCATGTACTTCCTGAGGGAGCGACTCTTCCGTAGCCTTGCACATGCAAGGCTGTCACTTGCATGAAGTATATGTCTTCAGACTCACCTTTTCTTCACCCCCACTGACAATCTCTGTCTCCCTGGACTCAGGCCCTCTTTCCTGCCCTGCCTCTTCAAGCACCCCTCCCTGCTGTCCTTACGGAGCCCCCCTGCAAGGTTAGTGGTTCATCTGATGTGAAGATTGCAGTGAAGATCTGAAGGCTCTTCAAAGCTTTGGGAACTGGTCATGACTTAAGGCTGCAGAAACCAAGCTTTGCTTTATGGAGCTTGTAAACTTACATCTTGTTTGCTCGTCTACTTCTTGACTGTTTGAAGCATCAGGTTGACTTGCAAGCTAACTCTAGGAATCTCCCAAAACCAGCACTTCCTATTAGAAGTATTTCCACGCTGTGGTAGATGCTGGGATGCAAGCTCAGTCGTCACCCCCTCCCCCCACTGAGGTACCACCTTTTCTAGAACTCAGGCGGCTGTACCATGTGTATGTTCCTCTCGTGTAGTTGAGAAGAAAGAACCTCTTTGGCTCTCTAGGATCTTGTTGTACAAGTCTTCACGTTCTTATTTCCTCTCTCTCTTTTGATTAATTTCTCTGGGATTACTGGTTCCTATGTCCTCACAGGTATCATGAATGGTTTCTTCAGATTGAAGCATTCCTTCCACTGCCTTCAGGAGCTCGGGGTGGGTGAATAGTCTCTTTTAAACCAGCTACTTCATATTTCAAAATATTTTAAGCATACAAGTTGTAAAGTTCTATATAACAAATACCATGTACCAAAATTAATAAATTTAATAGATGGTAATATTTTGCCTATTTGCTATCTGTCTATCTGTTCTCTCTCTCTCTCTCTCTCTCTCTCTGATTCTCTCTGAAGTACAACATAGTTACAGTGGGAGCCCCTACTCAGCCACTGCTCTGTCCTCTTATCCTCTTTCTTTGCCCAAAGGAAAACCACTGTTCTGAACATTCTTTATCTGAGATGCATTCATATCATATACTAAAATCACTTTCAAGAAAGTTACTTTTTACTATCTTTAATCCAAAGTTTTTTATTATATATGGTGGCTCTTTTTCAAACTATATCCAGGTTAAAACTGGGCCCCTGAAGGCTTAAACATTGATTGCTTTAATCCAGTCTCTTCCTCTTTATTGTTTGACTAAAAATGTCTTCAGTCACAGTGTGGAATTTATGCTGACCCTTAAACCAAAAAATCATATTCATGAGGAAGCTAGGGAAAATAAATATCCAGAATTTAAGAAACTTTTCCACTTTTAAAAAATGGAGTAATCCACTGTCTAGCCTGTAAGCTCTCCCTCCAGTGTTTGCTTGGTTCTGACTTTATCTGCCCCTCCTGGGAGAACAGGAGAGACAGCAGAGCTCCTCTGCGCCAAGCCTGTCGCTACCTGTTCTTGACTCAGCAAGGAGTGCCAGGGAAGGCTCACTGCCCTCCTTTTCCCGAAAGTGCTCCACAAAAATTTTAAATCAAACTGTCTTCCTTGAGCAAATGGAACAGCGCCAAGAGGAGAAGCCACACGTGGCTTTAGGAATGCGCCTGCAGCCCGTCCTCACTTGCTTGAGTCCTTCTGTGCTGGGCACCTTGTGAACATTGCACTTGGACATCAGTGACTTTCATTTCTAAAAGACAGTTTGTTTGTAATCATCCAATGCCAGGAGGTTGGAACACAGTGATGCTAATATGACGATTCTGATCAGCTTTGCTGGCAGCTGCCCTGCCTGCCACTCTCCTCCGGTTTGATCCTTAAACAACCGGTTTATTGGAATGTTTCTGTGAACAACAGCTTTGGCTCCGTTCTCCCACCTCCTGTAGTGTGCACTCTTACGTGCCTCTCACTGAACAGTCCTTAATGTTACGTTTCCGTCAAGGTTAATAAAGCCCGGCTGATCTGCTGTACGCTTGAGGATATCACATATCTTTGCAAAAGCGCCCTTTCCCTTGCACAGGCTTGTCTGCATCCGGAGACTTGCCATCCTAAAGATCTACTTGCAATACTAATTTTGAATAATTTAGCCTGATCCAGTTACCTAACATGCCAGGGGGGAAAGATCACCACAACAGATTGGGCATTCAGAACCTACCTAGTTCATAGCATTTATTAGAATGTCCTTTGACACTTCCAAGTGTTTACTGTGCTCAAATAAAAGAAAAGAGCTATCTTCCCTACCAATACTATAGTCTGTGCTTTGTAACACACACACACACACACACACACACAAACACAGAGTTTATTAAAACAAGGGCTTTGTAACCCAAGGTTCATGGATCCTTTTGTGGTTTCAGAAAGGTTTGCAACCTCTGACTCTACACATAGAGTTTTATGCATATTTGTATGCATTTTTAAAGACTCCAACATGTGTAAAAGTAATGCTGAAGGGCATTGGCTTTTTTACCACAGCTGATTAAATCCATCTCTACAATTTTGGAGGGATGGGGGCGGGGGCGGCGCGAGGCCGACTGGCTCTCACTGTGTAGCTTACCCTGGCCTTGAACTCATCTTCCTACCTCTGCCTCCAGAGTATTGACAAATTCCAGGGATGCAACTGTCTTGAATGTTTTTCTTCTTTCTTTTTTCATTTCAAAAATTTACATTTACACTTTTTAGTTTTACCCATTTTAGGCAAGTTGAACCGCTTTGTGTTTCTCAGCATGTAATTCAAGCTAGTTGCTCTTTAGTATTCCATTGACTGGAAAAGATGTGAGATTTAGCGCCTCCTCACACACACACACACACCACACCCCACCCCCGCCTTTCTGTTCTCTCCTTCCTCCCCTCTCCTCCCTCTCTCCCACTCCCACCGACTCTCTTGCCACTGACTAAATACGATGGTTCAAAACCAAAAAGAAAACAGAATCATTTCCCTGATATTCACTCACCACGGTGGCAAGTCCTGCACTACAAGGAGGTAACATCCTCTCCGTGCCCATAATAATCTAGACTTCTGCATAACTTTTCTTCTACGTATCCCAGGCGTTTTGCGATTGCCTCCATGAGTAAAATACTGACTTGTTAAAAAACAAACAAACAAACAAAAAAACCACCCCTTTATTTCACTGTTAGCATTAGAACTTAGAGAAAGCTGCTTACTGAAGGAAACTGTTGAGCAGTGAGAATTGATCCTGAGAGTTAGCAGAGCCAAGCTCCTGAGGGTTGCAGGTTGTCTGACTTTCCAGGCTTGGTATGGTGGCCTGCCTCGCCTAACATTTCCTCTTCCCCTCTCCTGTTTCTCTGCATACTCATTGCTCTTGGGATGCTTGTTCCTAGTGCCAGTGTTCAGTCTGAAATCATCTCTGATCAAAGTGGTCTCTGTTTGAAGAGGATCATTACATTCAGGCCGCCAATCCCGGTTTCGTAAAGCCACATCTGAAGATTGGTTTTGATGAGGCAGAGTCAGTAACCAGAGCCTATCATCCTCATGTCCCCAGCCACCTTCTCCATAGTCAGCGTCTAGGGTCTTTGGTGGGTCTAGGGATCTTCTCCTCGCTCTCCTGCAGTCCCCATCTTCCCCCTCCCACTCTAAGTCGATTTTAGGTCAGTCTTCCAAACAACTTTCACTTTCTTGAGGTCTAATGGAGGTGAGTGGGAGGATATCTGGGCAGACATGTGAAACAATCCAGTCTGAAGACCAGGGGAATGCAGAGTAAGTCCCCAGCATCTTCAGATAACCGAGTTATCTATCCATTGCTTCATAGATAAGTACAAAACAGGTTTGCTTGTATTAGAGAAGACTTGGAATTGAAAACAAGCCACAAGAAGCTAAGGCCAAACACACATTTTTCAAATCACATATCATTGAAATGGTCTAGACATTCGAAAAACAATCATCAGGTCGCACAGTCGATAATGAGGTTTCTCGGGGTGGAACAGAGAACCGTGGAGGCTGGGAGAAAGGGAGAGCTGAAAGCAGAGCACAGGGTGTCTAGCTGAAGTCCTGGGAGAAACTAACATGGCTGCATGTGTGTCTCTCTCCTTCTCTACGCACAGCTCTCAGATTGGCATGCAGTACTCAGCTTGTGGGCAACATATTCACGGTGTTAAGCACCAGCTGTGAACTGATGGCCAGCGTGGGGTGTGACATTACTTCCTAGATTCTCATTGGCTAAGCTTTGTCAACTGATGGCCAGCGTGGGGTGTGACGTCACTTCCTAGATTCTCATTGGCTAACCTTTGTGAACTGATGGCCAGTGTGGAGAGTCTCACTGGCTAAGCTGCAGCTTCTTCATCTGTAAAGCTGACGTAGAGAACCAACTCAATGCAACATGTGCCTACATTCAGTTGCTCAATGCCGGCACACAGTCAGCCTGGAAACACAATTACACCCGTTTTCATATAAAATTTCAGGAAATTGGGTACTACTCCAAAAGCTTGTGTTTAGAGGTAACACATGATGTCATACGAAACTCACACAAAACAACAGCATAGAAACAAGTGTTAGGTTTTGTTAGGTCCCTTCACTGTGTCCTGGTAGGCCCTATGTGTCTAATTTGCACAACGCTGTATTCATTCCTAGGTTGCCATAACAAATAACTGCAACCTGGGTCATATTAAACAACACAGTTTATTGTTCCAAAGTTCTGGAGGCCCAGAGTCCACAGTCAAGTTGCCAGTGTGGTCTTGCTTCCCACAGAGCCTTCAGGAAAGAGTCAATCCTGGCCTCTTCCAGTTTCGGGTACTTGTTGGCAGTCCTCAGCAAGCTCTAGCTGCAGCCACTTCTCTGATCTCTGCTTCTGTCTTCACAGGGCTCTTCTCCCTGACTTTGTATCTGAATCTCTCCCTCCTTTCCCTCGTAAAGACACCAGTCAGCGTGGTTAGGGACCACCACGCTGTGTAGCAGGACCTCTTCTTGACCAATCGCATGTGTAGGAACCCTGTCTGTACATGAAATCATGTTCTTAGCTCCTGCATAGGCCCGAGTCCTGGGAGATGCTCTTCTCACTTACTACAGGCACGATGTGCAGTGGTTACAGAGTGTTCCCGAGTGTGTGCATTTAAGGCCATGTCGTTCCGTGCTCTGCTCAGAAAGAAGCCTGTGTGCACCACGTGCTCCCCTGTGTACCTTTGTTACATTCAGGTAGTGCAAGAAAATCTCTCAGGTCTGAGGAAATTGCTGTACTAGGGTTTTGAACATTTATTCTAGTAGATGGAAGGTGTGCTAGAAAGTGTCTGCCATCAGACTCTTGGATGGCACTCTGAATTGTAGCATCTGCCAGTTTCCTTCCCATAGTAAATTTCAGGCTGCTAACATGAAGTCAACTGGCTTGCAATAAATAAATAAATAGATAAATAAATAAATATTTTAAAAAACAGTGAAAATTTAACTATTCTGAAATTAACTCCATGAACTAGTCAACCGGTTTCTAACCTACTAGGTGTTAAGCCAGCAAAGTTAGAGCGAGAGAAGGTGATACATTGTTTCCTGTAGGAGCTACTTTCTATGCACATGTTACATAATATAAAGATCTGCAGGCTATGACGGAACCCCATAGGTGTTACAGCTGGGACTTCATTGTGTGATAGTTAAAGAGAGCTGCGGTTGAGTGGGATTACTGCTGTTTAGAAGCAAGGCTAGACCTCGGTCCCATTCTGCCACTCGCTCGCAGGTGGGGTGTTCTTCAGAAAGTTGCTAAAGATCTTCAAACTTGGTTTTGTTTATGAGATGAAAGTAGAAACAACTCCTTCACAGGAACCATGCGTGCTTACGTAAAAAACTGACCTCTTAGAAAGGCAGCTGCCATACTCCTGGCACATCTGCCTCATTAAGTGCTCATTCGGACACGTGTGTAGAAAGAGCCATGGAGATGACTGTTTTTTTCCTGAGAGCAGAAGCTTGCAGGTACTTTGTCAACAGCACCTAGAAGGATGCCCATGTATAGCACACACGCAGCAGTTACTTGTACAGTGAGCAGGTGGTCAGTGCTCAGAAGCTGGAAGGATCATCTAAGGAGGCACTTGTCCTCCCATGGTGGCGCTAAGCAAGTCACTGGAGTGGCCACCAGGTCTCCACCTGTCACTGCTGCTCACTCCCCACCAGCCTGCTCCTCTTTCCTTCTCCAGCCTGGCATGACTGCCAGCCAGGACAGCCACATCCCAGACCTGGCTGTACACTGTAGTGTAGCTCTTAGACATAGCACCAATCTATTCTGGGTTGAAACTGGCTTTTCTGCCTTACTTTCTAAACCTATTTTAACTGTCCAATTGCAAAATAACACTTAAAGAAACTAAAAAGGTTTAAGCAAAATAGACATTTATTTATTTTAAAAACTGAAAATTCTAAGGGAAGAAGTAGAAAAAAGAAACCCAAACAAACAAACAAATTTGCCAAATCCGTAGAAAAACTCCCATTGGGCTTTTTAGCATCTCGACTTCTACCTTAGAGGCCACTCAGCAGCAGCAGGCTCACTGTGAGAAGACCTGCATTCCCAAAGCTGACATCAAAGCTTATGAGACACCCAACTGGCAGTTCCTAGGCCTTTGGTACTCTGAGTTGTTCCACTGCCTGCCCCTGCAGCAGTGAGACAGGGGATAGGGTTGAGCCCTGTGTCCGTCAGTCGCATACTCTGCCGCTGGTTCTACAAGTGGGATTAGTCACTGACTAGCAACATGGGGAATGAACTGAGCTTAGGATTCACTGAGCAAAGAGCTATGCGCTAGTGACACGCGGATGCTCCAAGATCACAAGGATTAGCTCATTCGTCCATCCCGTGACCAGCCTACAGTTTCTGAACTCTCATTCCTAACAGTTGGTAAACCCGGGTTCCTCTCTTCAGAATGACTGTTCCATGCTACTCCTAATATATGAAACTTTTGTTTTTAAAATAAACCAAAAAGTTTTTTGTTTATTTACAGATATCACTTGCATTTAATAAAATTTCAAGAAACACAAACTTATAGCTAGTAAGTCCCCTTCTCTCCAAGATTCCTTTGTTCCCTGGAGAGGAGAGCTGTTAGGGGCTTCTCAAGTGCACTCCCAACCGTGCCTGCCGTGTGTTTACCATGTGTGTTTATACCTGCTGGCACACTTCCACTCACGCTTCCTCCTGTAAGTAAGCATTAGTGTACCGCTTGTGAGCACCGATGTAGTCTACTAATCTATCAACCATCTGCTGCTTACTTTTTTCACTTACTGAGTCTGAAATTTGCTCAGATTAACAGCAAACTCCAGAGCTGGCAAATCCAGATTCAAGTCCAGCTCTGTCCCCTGACTAACTGTGTAACCTTGAGCTAACTGACCACCTTCTCTGTGCCCCTATCCAACTAGCATAAGAACAACTCCATGTCTCATAGTGTTGTTGGGAGTACTAATTGAATTAGTGTTGAAAGAGCAATGTCTGCTCCAGGGAACAGTTCTGATGTTCAATTTCCTACCCATCTACTCTGTAAAGGCTGTGTGCTTTCCATGGCTGCTTGGGGCATGCTGTCTTCTCTAAGCTCCATCTGTCTTCTATCACAGGCCAACCTTAGTAACCCTGCATGATAGTAACTTCTCCCTTATCCTCGGGTCTTTGTCACTTTGGGATGTTTTGTTATTGAGATAGCTTTTTAAAAATACTTATTCATTTTTATTTTATGTGTCTGAGTGTTTTTGCATACATGTATGTATCTGCACCATATGTATGCAGTCCCCACGCGGGCCACAAGACGGCGTTGGAATCCCTGAAACTGGCGTTGCAGTTGGTTTTGAGCAGCCATGGGGATATGCTAGAAGAGCAGAAAGTGTTTTTAACCACAGAGCCATTTCTCCAGCCCAGAGATACCATTTTAAAATTATAATCTGTGACTGTTTTGTTTTGTTTTGTTTTGTTCAAACTAGGTTTTACCATCAAGCCCCCTAGCTGGCCAGGAACCCACTGTATAGACAAGTCTGGAATGGGACTCACAGAGGTTGGCCTGCCTCTGCCTCCCAAGTGCTGAGATTAAATGCATGTGCCACTGTGTCTAACCCTTTCTTAATGTAGTGTGTTTATTCTTTGAAGAGTCATAAACTAGATTTTCACCATATTCACTTCCCACTGTTCTTTTTAGCTCTTCTGAGGTCTACCTCCTACCTCCTCTCAGTTTCTTCCTTCCTTCCTCCCTCCCTTCCTTCCTTCCTCCCTTCCTTCCTTCCTTCCTTAATTCATTCATTCCTTTCTTTCTGCCTATGTACTAATGGATATGAGACTATCCACTGACCATCGTCATTCCTATAAACATTTTCCTTTCATAAATGTTACTCTATGCATGTGGAGGTCAGACGCAGCTTTCTAAGGTCAGTTCTCACTTTCTGCCTCTCTCTCTTGTTCCCCACTGTGATCCATCCTCCAGACTTGATGGCCCTGGAGCTCCCAGCTGGTTCTCCTGTCTCTGCCTCCCATCTCTCTATGGGGTGTTGGGATTATAGATGTGCATCACCTAATAGGCCTTTTTACCTGGGTCCCAGGGTCTCAAACTCAAGTTGCTGTGATACGCATATATAACAATGCTTTTACTCATGACCCTCCCTGGATGCTGAATTTTTTTTTATCATAGCTTTATTTTCACTCTTTATTGTGCCATTTGCTTCTTATATGTTTAATGATGTGTTTTTCAATGTGATGACCCTTTCAGAGAGTCTGCCCTCAGTTGTTCCCAGGCCTCCCCCACTTCAGTGTCTTCTGGGGATGCCTTCCTAATGAGCCCCATGCGGACTCTGATGGCTGCCGTACTATGTCTTACTCAGATGTGCCCCTCCTCATTTCTAGACCTTATTTCATGTGCATAACAACTGTGTCTTTTTACATTCCCTAACACTGTGCTCAGTTAAATTCCTTTTCATTCTTGGGTACTAGGTGATTACCCCAGTTAGCAATAGAAATATGCAATTAGTATTACACATAAGAGGAAACATCTCTCTCCCGTTCATCTCTTACTGAGCTCTTGCTGTGTCTCACAGCCAATCATATTCAGCTCCACCAGGGAGGCGTTGGTATCCTAGTTTTCAATTGGGTTTGATGAACACTTGGCCAAAAACAGCTTGTCTGTCTACCTTTCTTATGTACATGCACACACACATATCTCCTAATTACTTTCCCCAGCCTAGACTTCTCCAGAAAACCACCCTTCACATCTGCCTACTTCCTCCACTTTACCATTTGGATACCTCGTAGCCTTGCTGAGCTCAAAGTTGAATGCTTGATTCCCTACTTGAAGTTGTCCACTCTTAGAAAATGGTAACCCATCCCCCAGTTTCTCAGACCAAGCGGTCTTCAAGTTATTCTTCACGCTCCTCTTCTTGATCACCACTTATAATCTACCCTACTGGCTATTTCTTCAAACTAATTAGAATCTACTTGCTTGTTGCCACCTCCACCCCATCACCCCTGGTATAAACCATCCCCCTCCTAATCCCTCCCATTTGCATCGGTGATGCCTGTCTCAAGCAGGTATTGCTAACTGATTACAAATTTAGGGTTTGCTCTATCATTTTTTTTGTTAGATAGCATTTATCTTTTTGTACTTTTCAAAGTAGTTTTCTCTTCTTCACACTCACTGGGGGGTATTTCAGACTAGTTTAAATGTTTCTAATCTAAAAACACAAAGTCAAAAAATGCTCTGAAAGAACCAGGGGAAAATGAATGGGGGTGGGGGGGGGGGTAAAGTACTTGTCATACAAGCATGAAGAGCTTGAGTCCCCAGAACCCACACCACAGCTCAATGCAGTATAGTAGTCCAACCCTCTATAATCTCATTGCTCCTGTACAGAAATGGGACGTAGGCACTGCAGACTCCCTGGAAATTTACCTGTGGTCCTGAGCGTGTCAGCTGACTCCACTTCTGGATCCTCTTCTCATCCCCGAGCCACGCATCACTCCTGCCATGATTTACTGTGATATTTGAACGCTGCTTGTCACCAACCAGCAGAAGTGTTGCATGCCAGCTCTCGTGTCCGCTACACCTCGCTCCCCCACTCCTAACTGACTGGGCTCATCCTCCATCTCCTCCTCTGTCCTGAAATCCCTCATCTGTCCAAGGGACCTGATTCCTTAGCAGAGTCGCTTTTCCTACGTTTTCCTGAGGCTCCATCATTGATCTTTTTTGTTGTTGTTGTTTTTAAGTCTTGAGTTCAGAGCCTATTTCACACATCTCATTGTTGCCATCATCACAGACTCTCCTTCCCTCCCCATCCTAGCTTTGTATCTCCTTTTCCCAATAAAATGCAAACCCTCATTCCCAATAACACTAGAAGTGCCTACTCAGTTGATTGGTCCTACAATACTTCCAAACACATGGGGAGATAGTATGGTTTCAGGATGACGACGCCAGTATCAGCCCTACCAACTTAACAAAGAGTTCCCTTTTCTTTTTATTTCTTTAACCAAAATTCAGCAGCCAATAATCAACCAGAATACCGTTTTCATGGGTTACATTCTTTTCCTTCTAGGAAACTCCCTTACCATTGAACTATAGGCTTAGAATACTTTGTTTATGATGAATCTTAAGAGTTTTCCTATTCCTGCTGATTTTGTTTTATTTTTGAATGGTGGCATGTATCGCCCTCAATTACCTTCCATTTGTGTCAGATAAACTGGACGATTTGGGAACTATCATAAAGTCCGTTTGCTTTATTACCTTTTAATCACAGAGAGGAACAAAGAGTTCTGGGATGGTTATTCTCGAATGTGAACCCAGTAAGCTCACGTTGTCACATGGGGTGTTCCATTTCTATATTTGGAGCCCTCTTAGTCTTCCTCACAGTCACAGAGTACACACATATATGGTTCTCGCACATAGGCTTGGTGCTGGCTCTGCGGTCACAGACACGAATGAGTTTATTCCTCTGCCCCCAGGTTACAGAGAGTAGCCAAGCAGCAGACACGTATGAGATGATACTGGGGTGTTTCCTTGGAATTTGGGGAGGATGCTCTGCAGTGGGGTGCATATGTGTATGTGTGTGTATGTTCCTGAAGTGGGTGCCCTTCCCTGAATGCATTCCTACTGTGTAGTCATTCCAAACTTCTGATGGTGGAATGCCAGGATCACAGAGCACTTTTCATACTGGATGTCAGAGGCATGGCCCCTTCACAACACACGTGCTTCACTGTCAGAGCGGTGGGCCTGTCACACTGCGTCTGCCTCAGAGATAACATAATCTTCCAAGCTGGTGATGTCATCCTGGAGACACACAGCCAACGATGAGCCCCAGGGGATTGTTCCTAACCATTTTAACAAGTCTCACCCCTAAAGTCTTTATGGTTCTTATCAAGTTTTTTGACAAGAAGTGGTAGATAACAAATACTTTAAATTCAAATTAATCTTGAAAACTGGAGCGAAGTGCCAAACTCTTCAGCCTTGATGTTGAACAGAGACACACACATCCAGAAAAAAAACAATGAATCCACAAAAGTACACAGCAGAGGGCTGAGTCACCAGCAGTACATGCGGAGAGAGTAGAGTTGACGTGCCTAGCAAGAGCTAGCAAGGCCTGCAGCTGCCAAAGAAGTCGCTCCTCACTAGGCAACAGTAATGGAAATATGATGTATAAGAGCCAAGAGGTGATAGTCTCATGGCCACCCTCCAGGAAGATCACACTAGATGCGTGCAGCCTGCTGGGCAGAGCACAGTAGTCGGCTGTGCCCGGGGCGGGGCCAGATCAGGATGGTTGTGTGACCACACTGGAATGGCTTACAGCATGCTCCTGGCTGTCCTCGGTGTTTGAATAGCTATTATAAGAAAATGGAAATCGACCCCACCATCACAACACAGGGGAAAGAGGGAGCGGTGAGCTGAAGTCCCACAAGACACCACCTTCGTGGGAATCACAGCCACCACAGGACGGGGTAACTTTGTCGTCACTGCTCTGAACTAACCTGAAAGACGGTAGAGGAAGAAAGGGAGGCTGCGTGGCCTTCAGCTTCACAGCCTCGGAGTCTCTGGCTCTCCATCCCTGTTTTATATGGCATTACACACAGTTTTGCTTAGTAAATCATACCTTTGTAACAAGGGCTGATCAAGATTTGCGTACAAGGAAGTTATAATTTCATAATTTCATGATAGATAAGAAAATATAACAATAGATGCTAGTGACTTGCTGGCCATTTTCTCCATGGGTCAAAGTGCATGACTTATTTTTTTACACTAGTATGTCAGTTTATTAACACAGGCCGAACAGTTTAGTCACACCTTGAAAGGGTTTGGTTTGGTTTGGTCCTGAAAGACCAGGTACAGAGTGATACCAGATTTTTCCAACAACTTGCTGGCATTATCCTAGAAATCAGTAGAACTTTTGGTGTTTACCCCTCCATGCCTTGGTCTACATCATGCTATGCAGATGGCACACTGCTTTCGTTAACCTCAGTCTGACACGCAGATCGTGAGTTCTCTTCTGCCATGCTCCTGTCTGGCGGCGTGATGTGACCGATGAAGTGTCACCAAGAAATAAGACAAAATTTCCCAGGTCTACTCACTGGCAATTCTCTTTATTTAGTAGGGGTTTTCCACAGGAAATTGCAGGAGAAGAGTTGAAGTGCTCTTTGTCTTGTGTACTTTCCTCTGACTTTTCTCCTTCCCAGAGTGGCCCACATTGCCTTGTAAAGGAGCTGTGTTGAGCATGATACTGATCAAAGTCAGAGTGCGTTCTGCCAGTCAGCTAAAGCCTCATTGCTCCTCTGCAGTGGACTTCTGTAGTTAAACTCTGTTTTCCAAACATGAAAACACATAAACAAGCACTGGAGATATGGCTCAGCAGCTAAGATCACATACTTCTTCTGCAGAAGACCCACGTTCCGTTCTAAGCACCCACATCGGGCAACTCACAACTGCCTATAACTCCAGCTCCAGGGGACCCAACACACTCCTCTGGCCTCTATGTGCACCTGCACTCATGGGCACATATTCACACATATATACATAATTTAAAATAAAAATCTTTTAAAAATTAAGGAACATATACCCACAGAGTAAGTATTTGTCTCTAAGAAGAAATAAATCGGTGATATTAATCTGAAACAAATTTGGACATCACAGAATCAAAAATATTTCTGATTATCCTAAATTAACATCAAAATCATTTTAACCGAATTCTGGAGAGGTGGCTCATTGGCTAAGCTCTTCTCTCCTCTTGCAAAAGACCCAGGTTTAGCACCCAGGACCCACATGGCAGCTTCCCAACTCACACCCATCTGTTGTCCCAGTGCCAGGAGACCTCACACCCTCTTCTGGCCTCTGCAAGCACCTGCACACACATGGTGCACGTATTTCAGGGAAAACAATTATAGACATAAAATTCAAATTAATTTTAAAATGTCATTGTAAGATCATGCTAGATAAATTTTCTATAAATCATGTCTGTTTTCAGACAGGGATTCTGTACAAATCTAACATGCATTTTAGACGACTTAGTTTTGAAGTTTACACAAACTTTTTTTAAAACTTTGCTTAAAATAGCTAATTATGACTTCATTTGCCTGTTTTGGCCCTGCCCCCCATGGCCAAAGCCTGCTGACATCCCCAGGACCAATAGTCCCTTATTCTCAGTACTATAATAAGTACTGAGCTCCCAGCGCACAGCCTGCACTGCAGTCACTGAAAAGCACTGTGTTGAGTACCCAGACCCAGCCTGGATGGGAAAAGTTAATATCATTGCCTAACATGAAGGTTTTCTTTGTCTCTAAATTTTGATTTTTCCATGCTATCAGAGGCCCCCTTGCAACAGGTAATCTGAGTGTTGTCTGTTTTCTCCGTCCGTCATCGTGGTTAAGTGTATTTTAGATGCTCACAATTCTAAAGCTAAATTGACTTGACAAGGTTCTTTCCGACCCAAATTCTGTGATGTCCGACTCTTTTTTTCTTCTTTTATTTTGGATTTGTGATTGTTGACCATTGTCCTGTATGTCTTACATATATACTTTAGGGAACCATAAGCATTTTAGAGCTGGAAGCCATGCTAGCTGTGGGCTAGGACTAGACATTTTGCAAAGAAAGCATTAGGAGACCAAAGTGGTTAGTGATTCAAACAAATTCATAGCAGTAGCTAAAGACTAAAATTCTGACCATCTTCAGAGGACTAAAAATAATCAAAGTGTTATCTGAAAATTTGTAACTCCAAGCCAGGTATATATATATATATATATATATATATATATATATATATGTTATGTATATATATTTTACCCCAAACAAATTAAAGCTTCCTATAATTCTGTACTCATATATGTATATGGGGTGTGTGTGTGTGGAGAGAGAGAGAGCAGGGAAAGAGAAGGGGAATTAAATATTTTTGATAACGTAAGCTTTGATAAGATCTGCCTGACACAAAATACAAAATGCATTTGGTATAAACAGCATCATTCTCCCTTTATACCAAAAACGGAAATTTCTTCGCATTCTATACATTTGAGAATGACACGTCGGGNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNUNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNCCGTGTTTGCTGCTCTGTACTGGCTATAACCTGCACAAGTAATGGCCTCAATACAACTCTTTTCTAATAAAAGCATGCCTGATGTTATACCTCTAAAGTAAGATTCGTTTATCTAGGTCTGCCATTGAGAGTGGTTATGGGAGGATTCCTGTCCAGCATTGGGACTGTATCTAAAAACAGCAGTCTAGCTAGAAAAAAACAGCACCTGTACAAAAAAACAAAAACAAAAACAAAAAAACCAGCAGACTCAAAATAGGAATCTCACAGGTCTAATCGGAATCCTCACTACTTCTCCTGCAGAAAACTATCCTTAAGAGACCCCAGGTCAAATAGTGTTCCAAAGAAAAACAGCCACATGTTGTGCAAAAAAGATAGACTATTGCTTTGTTTGTAAGGAGATGCGTCAGCCGTACGCGTTTTAATAGAGTGGTAATGAGCATCACTAATCCCTGAGCTTCAGACCACAGACTCGGCGTCTGTCTGCAAAGGGCCCTGAGTTGGAGCACTCTTGTGATTCATTCCTCTTCAGTTACACTTACACTTCAACCTAACATGGATAGGCAAGGCACTGAGATCAGAGGAAACGCCTGAQCACCGGGGGAGGGGCAGGGGACGACGACCCAAGTCCCCTGGCTCTCAAATTTGGCAGTTAAGTCCACATAAGAGGCAGCGCACTCCCACACACTACCACGCTTTTGGTACAGTCGCTCTGTTCAACAGGAGGCAACGTTAGCTTTAAGAAAAAAGGTAAGCTCGGCGTGGTGGTCCACGCCTTTAATCCTACCACTCGCGAAGCAGACCCAGGCCCATTTCTGAGTTCAAGACCAGCCTGGTCTTCAGACTGAGTTCCAGGACAGCCAGGGCTACACAGAGAAACCCTGTCTCGAAAAACCAAAAAAAAACAAAACAAAAAAAAAGAAGCAAGGTAATTAGTTAGGCTTCCGCACATCCACTGATAAACTGCTGTCAACAGAAGGCCTTCCTGCTAAGGGCTAGAAATCTCACACATGCTTATCTGAGAGATGAAAACACTGGGTTATTGGAGCGGGCTGTGAGAGCGACCGACCACACCCCGCCCATCTCTTTGACCACAGGACCCTAAGCAGACCCAGACGTATCAGGTCACAGTGGTGCTGGGGCTGCAGGCGGTTGTGAGCCTCTCCAAACAACCCCCCCATGAACAACCAAATTCACATCCACTCCAAGAGCAGCACCCTCTTAACCAACAAGCATCTGTCCAGCCTGTACACTCTAACTTAGTATCATATCGAGTAGATGACACAACTCCATCTTGTGGATGGATATCAGATAATGTGATGACTTCCAGAAAGAGACTAAGAGTCGTGGACCGGCGCTTGTGAGCTCTTTCAGAAGGGGAATGTAGCCAACCAGCTGGTGATGGCCGAGAAGCGACCTCACACCGACCACGTTTCACGGATTGTCATAGGTCAAACCATAAGTGACTCATGGGTTTCCAAACTTAACGCAGTCACAACCGTTAACCAACCTTTATTTCAAGACTAGTAGAAGTACTTAACTTTCAGAACACTTCCATCTGAGAAGCTGTTTCTCCCTGGTGACTAGAGTTGTTCTTGAACGCTTGGGTGTAGAGAAAGGAATTCAAGCAAGAGTGGGTAGACTCTTTTAAGAACCTTTCTCACAGACTTAGAAGAAGAAAAAAAAAAAAAAAACGTCAAATGAAACAAACAACCCCCCACCCCAAGCCAGCCCTGTTTTCTTGGAGTGGCACCTGCCGCCATGTGTTTGAATAAATGATAGCCTTTACCATCATCAACAAAGGGCTGCTATTTTTAGAATAAGAAAGCAAAGGAACTATGTGGATAGCTAAGGGCAAGGGTCATTTAGATGCTTTCTAGCGGTCGACAGTAATTAGGCGATCTAGAATAAATATTGTGGGTAAAACAAGATGGCTTTTCCTQGAAAAGGGAAGAGACACAGTTCTCTGAATTAGTGACAAGAACAGGTCCTGAGCTTCAGTAACAGAAAGGAGACACATTTGTCCAGGACCATTGTGGAGGCTTCTCGTTAGATCTCAGGAAATCCCAGCAGCAGATGTCTGTGAGGGCAAGAAGAGATAAAGGAGAATTATTTTGCATCAAGAACTGTTCTAAGCAATTTAAATTATCTCTTCTTAATCCTTGTGAAAACTCACAGACTATGACATTGAAAGTTAAACAACTTTCCCAGAGCCTGATATCAGCTTGTTATGGAGGGTCTAGGATTCAGAGCTATTCTGTCTGACTCCAACGCCTGTGTTCTTATGGTGAGAGGACTCACTAGTTTCAGGTCTTGGAAGTTCAGCCCTATATCATAGCAGGATGAGAACTTTGAGGGAGGTCCATCTGTCCATCAGAGAAGGATGCTCTAATATATTGGTTCTCAACCTACCTAATGCTGTGACTCTTTAATACAGTTCCTCATGTTGTGGTGACCCCCAACTATAAACTTATCTTTGTTGCTACTTCATTGCTGTAATTCTGCTACTGTTATGAATCATAATGTAAATATCTGATAGCAGGATGATCTTGGGTAACCCCTGTAAAAGGGTGGTTCAGCCCCCCAAAGAGTCTCTACCACCGGTTCAAAACTCCTGCTCTCCTCAGAAATTCTGAGGCTGAGAAATTGGGGTGGAACAAAACTGTAGACCCTGTAAGTCTGACAGAAGTTAAGATAAATGGACAGAAGACAATGTGAGGCAGATGCACGACACAAGACGCCTCAGGTCACCACCCAACTGGAAACAGGAGGGAAGGCAAAGGAGGGTTCTGACTTCATGGGGACAGCTGTTGGCTTGACTTGACTTTCTGGTGGTGATCACTGAAGAGTCTATTTCCACAGCTGCTGTGATTTCTTTGGAGGTTTCGGTACCAATTCTGGTCTACAGACAAGACCAGGGTCCTAGACACACAGTTAAGCTTAGGTTGTTCTCTGGTATTTAATAAACAAGCTGTAACTCAAATAGCTTGTTGAGAGGCTGTGTTGGGATCCACCTATCTTTAAACGCAAAACAAAAACCATATATCACTTTAATTTCTTCCTACCTAATATAACTGTTTACACTTTAGTAGTTTGCCTTCGATAAAGAACATTTAGTGCTATCTCAATTGTTAGTCACGCCCACGTTAACAAGGTAAAGTTACAGGAAGTACTGTGAGCACAAGGAATAGGAAGGACGGGTGAAAGCAACGCTTCTGTTCTTATAGTCCTTCCATTCTCACATAGAAGATAGGACATTATTGATACAGGGGACATGTTACATACTTAACAGTTATTAACATACAGAGAAAAGATGAAGCAGGGCAGAGAGCAGAAGATGGGGTGGTCGGAGCTTAGGTGGAGGAAGATTCGAAAAACACTTGTCTGAGAAGAGAGCTGTGCACAGACTGGAGCTGGACAGAAGACAGCAGACATCCTCGAACAATGTCCCACCTAAGCACGCAAGTCCAAAAGCTCTCTGGTGGGAGCCCTCTTGGCAAGTTCTGGAACAGCAGGGTCTACTATAGATGCATTGGAAATACAACAATCAAGGTTGAATCAGGACCCCACTCCCCCAAAACCCCCGAGGCTCCCTCACCCGCTGTCGACGCTTTTTAAGAATAGAGACATTAAAATGTTTTATTTACTTCTGTTCTTTAACATGGGAAATTGTAACCATGTATTCCCAGATCTGTGTGTTGACGCCCTTGTGCTAATCACTCAATTAACATGGGAAATTGTCATGTATTCACACAACTGTGTGTTGAGCCCCTGTGCTAATCACCCAGTTCCAAGTGTTTTCATTTTTGGAATTTTGAACTGAGGAATGATGACTTACCATGTCCTGACTTGAACAAAACTCACTCAGAACAGGTTCTGAGGAGGCACGCAGGGAGCCAGGGACTAGCCTGAGAAGTGGTTATTTGGGGCTTCGTTTGAAGATCTGGCTTGATTTTATTTATTTTCTAATTTTTTTCAAAAGAAGAACTGAAAAGGCAAATAGAACAGTGAAAAGAGAAAGCTAATAAACACGACCCAGCCCAGGCAGCACCCCTTCACACTTCACCTTCTACCTAGACGTGTACCTGCCTGGCAAAGGGCTGGCAGAGGGAATATTTCTAACACCATCCTATAAATGACAAGCCACATTCCTATGCTCTTATGCAATCATGGACTATTAAGCCCCCACACAAAGGTGAGGATTTGTCACATGTCACCAAAGCATTGAGACCCAATTGTACCTGAGGTACCTAGGGGCGCTTGACCTCTAGATATTTATGATGCATGTGATAAGTTTGAAAATTAAAAGGAAACCAAAAAGAAAACAAGGAAGCCCTGCATCAAGGCTGATGAGGTGAAACTTTCAGAACACGCGTACATGCAGGTAGACGTGTTTCTCTCTTCTCTTCTCTTCTCTTCTCTTCTCTTCTCTTCTCTTCTCTTCTCTTCTTTTTTCTCTTCTCTCTTCTCTTCTCTTCTCTTCTCTTCTCTTCCTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTATAGACTAGAGTTTATTCAGGGCCTGGGGAGGGGAGTTAAGAGGGTAGTGGAGTCACAGAAACCCAGACAGAGCGACAGAGTACAGAAGTAGTTCCTGGCCATGACCATGTCGAGAGAGAGGAGAACGGAATGGGGACAGAAGGGGAGCAAGAGGGAGAGGCAAGAGAGCAAGGCAAGACTGAGGTGTTACCCTCTTTCAGAGCAGGATGTCTGCAGGTAGAGGTATTACCTTCTTTCAGAGCAGAGGTGTCGGCAGTTAGAGGTGTTACCCTCTTTCAGGGCAGGGGTGTAGCCAGATAGAGGTTTTACTTGCCTGCTCTATATGAAACCCTCCTATCTGAGTGGTGGTTTGCCATTGTACTTCCAGCCTGACTCTTGAGATGTTGATCACACTACTAGGGAGTGTCAGGAACAGTGCAAATCCATGAACCCTGGTGAAGGTCCAAGTGTGCCAGCAATAGTGGTGAATCAAAGAGGTTTTCATGTATCCTGTCCCTCCTTTGCATTCCCACACCAATATTCAGAGGGCTAAGAGTGAACTCCACAGTCTTCTGCATCTTGGCTGTCTCTCCAAAGCTTACATCACTTGCTCAGGCTGTCTAAACTTGCCTTCTTATCTGCAAGTTAGGGTACTACTAGTGCCAACCCTGCCTATCTCAGGGTCATCAGAAAGCCCAGATGTTCTCCATAGATAAGAGGGAAGGACAAANNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNCAAGACGAGACCAGTGTCATGAGTCCTTCCTATGCCATTAGCTATAATCCCGTTTAGCAGGCTTGATCTGTGCTTCCTGGTTGCACAAATAAATAATAAAGAACAGTAAACTGACTCCCTGTCATCCTTGAGAGGACATACATTATTAAACCAATATACTATTTCGTCTCTCTCCCTCCCTCCCTCCTTTCCTTCTTTATAATTTGACTTGACTCAAGAAGAGTAACCAAGTAGCCTTTTTTTTTTTTTTTCTTTAAATGGAAAAGACTTTCAGGATGACAAGGGGACTCTTGCTCCTCCTTTTCACACCTAGCATGAGGCCTTTCTCACAATATGCCTCACCAGTGCCAACAAACAAGCAGCACTCTCTGTAGCTGTACCTGTGCTCAGATCGGTGATTACAGCCATGGCGCATTAAAGCCAGTTAGAGAGAGAAAAATAACCGAGCCGAGTGTTGACATCGTGCCGTGGAAATGTGAATACACTTTGGGGACGCAATGGCAGACCCCGAGTTCAGGGCACCACCACCTTACCCCAAACCATTGGAACCAGGTGGTGCATGTTACTTGAGCTTGCAAAGGGCTGGTTCTTTCCCCGGTCATATCCGGTGCCACTACTCACCCCACATGGCTATTGTGGCGATTTCTCCCTCCTCGGCTGTAGAGACAGAATATGCACATAGACTTAGATGAGCACGTGCTCTGGGAAATGAACAAGCATGCGAAGTAAGGCGTTATTTAACTCTTACTACCCAGTCACATATCACTTTCCTACCCTATGTCCTCCAGTCATTCTCGAAAAGGGCACAGTCGTGGACCCATGATGGGCTGACATTGTGAGGAAGGTGGGAAACACAAGAGACACGGGCTATTGGTGCAGCTGCTTGAAGGAACTCCTCCTGTCCGCTGTTAATGACCAGCATCAGGGCTCGAGAGCACTCACCACCCTGCGAGCATGACTCCCCTCCACCTGCTGAGAATGCCTTTCGAGCATGCGCTCTACCCGCCCGCAGAGAACGCCTGCCAACCTGCCTCATCCTCCACTTGCTCCTTGCTTACTCAGCTCAACTCTGCCTTCAAATCTCAGTCCGCATGAGTTAAACACACGGAAGCTTTCTCTCACTTCCCAACCGTGCCAGACACTGTTATTAGACATTCTGTTTGATGAGTTCTCCAGTTAGGTTTTACCTGTATTGTTGAAGTTATCCAGTTAGCGTCAGTCCCACTGTTTAATTCCGTGAGAGAAAGAAATTGGGCTTGTTCTCAACGACGTCTACCCCCCACTCTCTGACCTTCTACAGTGTGCCGCTCTTAGAAAGGGGCGTAACAAACTAAACTGGTAAACTTTAGTACTCAGTGAAATAATGGGCTAGATAAGAAACAATTTTCTGAGATTGTTGATATCATCAGGAACCAAGTGTTGTCTTAACTCCTTTAATCTTAAAACAGTCCGGTGATACTTCGTCATTAATTTGATTTTTGAAGGTGGAGAAGCTGACACACGTCACTCCACGACAGCTGGGGGATTTGACCCTGCCTTTGACAGATCTTAACCTAACCATGACCTGCTGTGGTAAACAGCAAGGTTGGGTTCACAACCACAGCCAGGCCCTGTTAGAACCCTGAGGATGTTCGAAAGAAAAAATCAGCAGAAAAGAATGATTTTAGGTATGATGTCTTACATTTATGCTCCTTCTCCTTTCTGTCAGAGTACGTTAGCCGAATTCACCCAGAGAGCAGCCTGGCTTTTGAAACTGTGATTCTGAGGAAGTTCTAGGCCACTCATCTCTTGTTACCCCTTTGAAGAAACAGCAAATCCTTTTCCACAGTACGTCAGGGCTATCTGACCTTAAAAAAAAAAAAAACTACGTGGCTGACTAAGAGCCCTATACCTGAGCCCATGACTTGTAGTTTTTATTCTTAAAGGACCTCTCACCCATGCACCCAGAATTCTAGAAGACTTTTCCTTCATCACGCAACCCCAAGGAAGTCTGATTGTCCCCAACAAGGGCAGCTGACACTAGAAATAACATAGTATTTTGTAGAAAAATAAACATAGCAAAAGAAAGAAAATAAATGTATTTGTAGAAAACTAACAAAACACTGCAATGTAGGAAAAAAGAAAAACCTTCCCCTTGGAATTGATGTGCCCCAAGTATCTTCCAGCCACTTCCTTCAAATGGACCTATTAGACATCCTCTAAGTGAGGCACCATCTGACACTCTGAGATAGCCCCTGAGGGTTGTCCTCTCCTCTGCTGACTACTCTTGTGAAGTGTTTCTGTACTTGAATGTATATATTCCTCATTAAACAGCCCCTTGACATTACTCAACAGGTGAAGAGACCAAGCAAGGTCACACAGACTGGAACTGCCTCTCCCCCCCAGCCAGCCTACCCTGTCTCTGAGGTCCACACTCTTCCCATTCCGAGCAGCTGACTATCCAGGATGCCTCCTTTGGCTTCTTACCTGTQCTTGA3T3CTTACAATTAAGAGTCTCTGTTCAGATTCTACTCTCAGAAAGACCTTCCTAGTAGACAGTTCCCCTCTATAAACTTTATCTTCAAGAGACGTAATACTTCCATTCCCTTCCCACAATAAGTTTCTACATTGGTGTTGAATACCTCTTGGCCACTATGGCATGATAAATGATGCTTCCAACAAATCGTTGTCAAGGTTTGCCTGTGCCGCACAGCTGTCCCCACAAGTAAGGCTTTCTTTCTCTCAGATGGCATCTTGGAAAGTACAGAAAGCCCAGGGCCCTCCCTGTTTTCATTCTGTGGTCTGTGTAAAAACCAAATGCTACCATCCCGACTACACTCTTTCAGATGGATCAAACAGCACATTGGTCACTGGCAGATCTTTCAGGTCCCTCACCTCAGAGTCCTCCCAGTTCCTCATTCTTGCCGCCCTTCAACCATGAAGTTAGTCGTAAAAGAAACACTAAGTGCTTCTTGAATGCACCTCCCACCTCTTTCCATCAGCGCCAGTGACTAACTAGCCTGTCAGCGCAGCTTCAGAAGGCTCGGATTCCAAACTCTCAGGCCTTCTCCCATGAGGCCTTTCTGCTTAAGTGGAAAGCCTGCCTGATTTCACCCAAGTGAAGCGCTTCCTTCAGCCTTCCTGTGCTGTGTTCCTGTGCACACTGTCAGTTAAAAGTGGGATCACCTCACTCGCTGCCTCTGCCCATCATTAGCAGACCGATGTGATCAGCCATCCAGAGCTGGAATCAGCCATCCAGGGACTTTGTAGGAAGAGCATCATCAGCCTTGGAGCAAAACCACAACTTGGTATTCATTGTCCTACACTTAAATGGGGAAGTATTTGGCCTGTGAAGAAACACGACTTGCTAAATTCACTTCATTTTAATATCAGAGACAGTTTTAAGTTCTGTGCCTAAGAAAGCAACTCATGCTTTGGGACAGTCAAGGTTAAAGTTAGTACAAAACCTTTCTCTGAATTAGGTCACTCTGTAACTATGGGAAGGCAGTCCTGCTGATCGCCTCCCCGCTCTGGAAGAAGTATGCCCTGGTCTGTTTTATGTTGTGTTAATTGACAAGCAAATTACACAGGATTAAAGTTTGCTTGGGCTGGGCTTTGAAGCCTGGGAGGGTTCAGGTTGTTGGTCAGCCATATCTGACAGGAACTTTGCACCCCAGGACAAGACAGGAAATTACATAACAAGAGAGGCCATCTTGGCTGAAGTATCTCTTCCTCTTTGTATAGCTCACAGCTCCGTAGATGACGGCTGGCTCTTATGGTGTATTCGATTTTACCTCCTAAAGATCAACTTCCAGACACCATCACTGGATTACATTTCTAGCAACTCAACGTCTCATGAGTTTCGGGGTGGGTTCAGAAGCAACTCATTATAATGTTGTATCAGGGCTCAGGCACCCAGCCCTCCTTGGGGAGTCTAGAGAGCTGGCTCGCTGGCCAGAAGGGAGACCGTTCGTTGTTCAGGGCAATGGTATCTTTTCTCCATACTCTCTGGGGAGTTACGCGAGCAGTGATCAGCTTCCCGGCTCTGACCATCAAAGGTTACACTGGAGAAAATCCATATTGAGAGCAAACTCTGTAGAGCCCTGCCTCCGTGGAGTCTGGACCCCGCTGATAGTAGTGATATTATAAGTGAGCAGGCTGAGGAAGGCTGTGTGTCTTTACAGGAACCTCCTTTAGCAGATGCAGGCTCTTCACGTTCACCTTGACATTTATCCAGAGAGCCGACGTACCTCATGCATTTCTAACAATAGGTGGGATTTATGGCAGGTTCTGACTTAATCGAATTCAGAGGGGAGTAATGCCTCCGAGCTACTCATGGTGTGACTCTCATGCTGTGATTTCCACGGTGTGATTCTCATGGTGTGGTTCTCATGTTGCCCCATCTTGACGAAAGTTCTACACTGTAGAGGTCGGGATGGTCAACTAGACAAGAAAAGACTTGGTCATCTCCTCTCTCCTGTCCTGTCCATTGCTGTTCTTACCACGTTACAAATACACAAGTGAAATGATCGCCTCACATGGAAAACTTAACTTTGTAAAACAAGAGCTAAACAACCAAATGTGAAACCTACAAATTTTTAGTCAGAAAGTTTGCTTTTTTTATTTAAGAAACTCACAGACTCCTGAACATATACAGTATAATGTCAGAACCCATGCCTGGGGAAACTACTGAAGAGTAGTGGGTGTCCTGTTAGGTGATGTGCACCAAGCAATGGGCTTATGTCATTAAAAACAGCCTCCAGAGCCAAGCCCCTGAACAACACTACCTTTCTGGTAATCACATGACAAGGAGTTAGGACTCAGTCTTTGTTTGTCTCTCTTACTTCATCAGTCACCCATTCCCTTCTCGTGCATGGTTTGCCCAGTTTTCATCACTGAAAATCGTGACAAGGTTTCAGAGAAGAAACAGTGTTGGTTAGTAAGGACCCTTGTGACAGTCCTACCTAATGAGGCATACTCTGTTTTCAGTGACTTGTTTCCTGGACATATAAACAACCCCCACTACCATTTTCATTTATTTCCATCCTGTCATGTCTTCATTGTATATTTTTTAAGTTGAGCTATAGTCAAATATGTATATATCTGCAAAATGTTGTATTTATGCTGATTGGTTCCATGTTACAGTCAGGTCAGATGTACTAACTGTTGAAAATGTCCTTCTCATATAGATTTGCAACTATGTGGGGCCTGCAAAGGTTATCGTTCAGTTGGTCACAAATGGAAAAAACATCCACCTGCACGCCCACAGCCTGGTGGGCAAGCACTGTGAGGACGGCGTATGCACCGTAACAGCAGGACCCAAGGACATGGTGGTTGCCTAAGTGGGCTGTGTGGTATGGAGGGAGCGGGAACACGCGGGTGTGAAATCCATAGGCCCCTTTCCTTGTGGACCTGTGCAAAGCCTGAGAGGGTCTCACACACGCGCAAGCAGATAAAGCCACGGGAATGTGTGTCCTCTCCTTTGAACTGCTAAGGAAATAGAGGTGACCAGATATCTGTCCTGCCTGAGACAATCCTTGCATCTGTAGTCTTGCCCTCTCAAGGATGGGTTTGGACAATGTTATAATTATAAGCCCTTGACCTAAGAGGCATTTGTGCCACTTTCAATTATATTTTTCTTCTCCTGGAATTAAAGATGAAGAAAACAATGAAACAACTACCTTAACTATATAGAAATGATTACCATGGAGATGCTTTTTGCTTCCTTCAAACAGCATCTCCACTATAGTTTAAGCTTACCTTGAACTCACATAGATCCTGTTGTCTCTACCTCCCAAGTGTTTGGGTGCTGGGATTAGAGATGTGTACCCCCCCACACACACACAGAGCTCTGATTTTTGCCTATTTGGGATTTTCTTAATAGAGTTCTAGTGGGAACATTTGAGACATCAAGCAGATAAGTAAATATTGTTTCAACTCTGCGCTACTTATAAAATGTGTGCTTTTTAAGTCAACAAGACATGCAAATTGGTTTCCGCACTCATTTGATCTGGAACATAAGTAGAAATTAGTGTATTCTTTCAAAGTCAGTCAAATACAACAATTTTTAGTGAATGAAATTTTATAGAAGTAATCTTACTTCAAAAGAATCACAAAATATTTAATAAGACATAATTATGGGCTGAGAGAGGATGAGTTTAGTTTGCAAGTATGATGGCCCAAGTTCAAACCCCTGGCCTCTCATAGCAGCGCTTTTCACAGCACAGGCATTTATCCTCCCAGCTCCTGCAGGGGAGCAAGAGGCAAAGACAGGAGAATCTGGAATCTCATGCAGTAGCTGGCCTGGTGTGGTGGACAGACACCAAACAGATCCCATGTCAAACCTGAAGTTCTCCTCACACCTCCATATGCACAGCACATCACATAGTCAGCTGCGTTCGCACACATAAAATAAGGGCACTCACTATGCTAAGGTTTTATATTTCATTATCCTGAAACACTAAAATAGCAGACAATGTAGTAACTTAAACAGCAAAAAATGATGTAAGCATTCAGTCATCTCAAATACAGATAACTCCTATTTTCCAGACTCTTAAAAAGCAAAGGGGATGATTCAGTGGGTAAGTGCACTTTCCACCAAATCTGAGACCCTGAGTCCAACTCCTGTAAGCCACATGGCAGGAGAGAACCAACTTCCACAAATTATTCTCCAACCTCCACATGCAACAAAGGTATAAGTGCACACACACACCATGTAATATAATTTTTAAATAAAAAAAAGTTAACTAAAATATTTTTAAAGCCAGAAGGTAAGAACTGGGGAGACAGGTCAGTGGGTAAACTATTTGCAATGCAACTTCAGGGCCTGAGTTCTGAGCTCCACCGCCCACATGAAAAATCCACGTGTTAAAAAAACCAAACTGATAAATAAAATAAAACCGGGAAAGGGCAGAGCACAGCGGTGCATGCCTTTAATCCTAGCACTCACGAGGCAGAGTCTAAGGCCAGCCTGGTCTACAGAGTGAGTTCCAGGACCGCCAGGGCTACACAGAGAGAGTCTGTCTCACTGCCCCCCAAAGCCACGTGTAGTGATGCACCTGGAACCCCAATGTCTCGCCACAGGGATGGAGCAGATCCGCGGGGCTCACAAGCCAGTCAGAAAACACCCCCCAGTCCATGACCCTGTCTCAAAAACCCGAGAAGTGACTGAGGAAAATTCCCTCCCTGTCTTCTCTGTGGTGCATGCAGATACATTGTTGTTAATTTTATTTAATTGTGTACATCATCATTCAGAGTTCTCCAGTCTTAGATCAAGTAGTGTCTGGGAACCCCAGTGAATGTCTCAACTTTTTTTAGGAGATTGCTTAGCCAGCCTTGATGAAGTCTGACTCTGTTGCCCTGCAATCTTGGGAGGTTCAGCTTTCAAAGTCCCAGGCATCATTTCTTCATTTGACGACCAAGATGCTCAAGTGTGAGAAGCTCCCAGAGAGAGGCCCCTTCCCTTTAAGTCATTCATCTCTGGTGCTTTTTGACGTTAGGGAGAAAACTATCCCAATTGGAGGAAGCTCAAGTTAGTTCTCGTGGACTTCAGCTTGTCTCGGCATCTCCTCGCTGCCCTGCTTCTCAATCTGCCGAAACTGACATGCAGGGTGACTGTCAGTTTTAGACAACTCATCGGTTAGTGTATTCCCTGATTGATTGCCCACATCATACCCAATCGTTTTGAACCATTTCCCTTCTTTTCGTCTTCCTTAATCTGTCTTACAATCATATGTTCTTAAGCAAATCACAGGTCAACTTTTCTATCAGTATTTCTGTCAGTAATATTTATTATTATAAAACTTCCAGAGTCTTGCTTCTCTGTTGGGTTTAAATAATCTTTCATGATTTAGAAGAAACTATGGTGGCTGTGTCTGCTGCTCTGAGGTAGACACAAGGCCTTGGGTTGCTCTCCCCTGCAGCACTACCGCCACTAAAAACACTAATGGCTGTTTATGCTGCACCCTAGGTTGCAGCGATGGACGTAAATTCAGTACCTGTAACCACAGCCGAGACCTCCCTCGGTGTCTTTTAGTGTAGTGGGGCACGCGCCTCTAGAGTTCCCACTCTCCATTACTCATGATTTAGCAAACATTTTCGACATCCGATTCCTGACTACCCTCCCTGTGGTTTGATCTACTCATAGCTGGGTGGGATTTTCTAAGGTGAGGAAACTTTCTCCCACACATGCAGTCCAGGAGATGCCGCCTCAGTGATAGGGGGTAACCACACTAGCTTTTCCCACCCAACAATCTCTCACTGTAGAATGTCTGCAGTCGCTTTCCCCCTTGCCATTTAGCTGACAGAATTCTGCTCATGGTATTTTCCCCAGACACCATTTTCTTCGTGATTCCCTTGTCTCTGTGTCTCTCAGTTTCTAACACGCTCCTACACCTTTTGCCTTTTCTTCTCTTTCTCTTGGATGGAAAAGCAGCGTGCTAGCAGCCGGGAAGTCAGAGCTCCTGTATGCTTCTGTCACTCTGCACGGCAGAAGGGATGGAGGCCAAGTTGCATCACTTTCTAAAGACTTGAATTCCTTTCCTTACAAAATCACAAACACACAGGCTCTGTCTATCTCCAGGCACTCAGTGTTTAACCCTCTAGACCAAGCCCACATTAGCTAATGTTATAAAACAGCAGGAGGAAACTTGCCACTATCTCCTCATGGTATGACATCGGTTATTTTATTTAGTTCTGACTTGTAGGCCAGAAGTTTAGGAAGGCAGCCAAAGCTCTTTCTTACACTTGTCAATACTAGAAATAGAACCAAGATAACATTTTCCAATACTACAGATTAGACTGAATATAGATTCACAAACAAGGCACCAGTCCAAACTATCAACATATGTAAAAATGACCCCAAGAAGACCAAGCTTTGAACACATCAAAACCAAACCGACCCCCTTTGTTTACAGTGTCTTTCACACTTTCTTCTCTGTTTGAATTCTTAATAACTTTAGTTTCTATTTTTCCAAATTATTTTATCAGTATTAGAACTATCATCTCTTGGGGTTTGATTATGGATTTGATTGTTTTAATATAGGGTCATTAACTTCAGTTAGCTTTCATTAGACCTCTTGTCTCTTATGCACTTAGTTAGACTTCACTGCCTTTCTTAATAAAAAAAAGAAGAAGAATCCTGTTTAGTATTCTATTTTGACCAGAATGTTAATATTTTTACCAACACTCTAGTTCTCTCAAATTTTTTGTTCAGTGGAAAATGTCTGTGCATTTCTACTTTGCTGTCCGCCACGTCCACCAAAAGTCACCACACCCTGTTTGCTTACTGGCAACCTGGCTTCAAAGAGATGTACAGTTCTTTTTATTTCCCCCTCCCAACTAATTTATGTACCTTATTGCAGTTGGTAAGCAGGAGAGCAGAGATTCTCAACCTGTCGGTTGCAACCCCTTTGCCCCTCAAATGGTCTTTTCACAGAGCATGCCTATGGAGATTTATATTAACCTTTATAACAGTGGCAAAATTACAGTTATGAAGCAGCAATGGAATAATTTTATGGTTGGAGGTCACCACAGCATGAGGAACTGTTAAAGTGTTGAAGCATGAGGAAGGCTCAGAGCCACTGCCCTGGATGATAGTAGATATGAGAACACACAGGAGAGCCTTTCGCCTCCCTCAGGAGAACTGCTACCTTAAATTACTGCTGGACAGATCCAGTGTAATTGTGTAGCTAAACACTAGCCCACAGGAGAGGCACTGCCTAGAGAAGGTTGGACAAATATGGACTTAGGTTCAAGGTGTGCCGTACCAAGTTGGTGTATGCACTGTGAGACGAGAGCTGCTTTTGAACACTGAAATCAAGGTCTGAAACAACAAAGGCCAAAGAGGGGCCACTGTGAGCCCCAACCCAGTGTTAGACACATCAAAATTTGAGCAACAGCTTCCAAATGATGATGAACATGAAACATCTGACCTACTTCAGCATGTTTATTGATGGCTACAGGTTTGACTCAGCCTGGGTCACTTCATAGAAAACTGATGCCAGCCTCCATCCCATAGAGTGGGATTTCACAGAGCAGTGAAAAGCCAGGCCCTCCAGCCTCAGCATTCCTCTTGAGTTAATGGAAAGGTTTGTTTGAAAAGTCCTGATTCCGTAGGGTTGGATGGAGCCCCAGATTTTTAGTAAATTCTAAAACAACACTGATGTTGCTAGTTAAAGACTCCCATGTTGTGAATATGAGAGGAAGAACCAAGGTTGTGGTTTCAGCCCTTTTATTAGTGGTTGTAGCCTTTCTGTTTTTAAAATGTCATTGCTGCAACACTCCTCCTCTCCAGTGTTCATTTCTGTGAATTTTGATAATCATGTGGCTACTCCTGATCTGAGGCTGATGAGTTCTCTTTGGTTTTATGTCTGAAAGTCGTCCCTTCATCTTCTCTGTTCAAAGGTGTTTTTTGAAGAGCAGAGGATTCTAAGTTGACAATATGTACTTTCATGTGCTGGTTTTATGTTGATTCACCGTCTCAGGTCTTGACCTGTTTCCAGCAAGAGCTCTCTGTACCTCTGCCTCGGCTCTACTGTTCCCAGAGTGTGATTGTTTCTCTAGCAGCGTCTTCACTTCTCTTTAGCACTCCTAAGCAGTGTGAGTTTTGATGGGTTTGAGGGTAGCTTTCTTTTTAAGCTTGAGCTTCTTAGTCGTCATAGATCCTTGGATTTACATTTCTTATTAAATCTTAAAGCTTTTCAACTGTTAAGTTTTCTGTCACTGTCACTGCCCCTGCTCCCCATTCCTGTTCTCTGTCACTTTCTCTCTTCCAGACTAGGGTTGAGTTGGCACAGTGACTAAGAGAATACCTTCTGAATAGTCAATCTGATGCCTCATCTATTCCGAGGCTTCCTGTTTATGAGAATAGTAGCTCTTTCCCTTAGCCTAACAGGGCTTTCTCACAAATGTTTCCTTTGGATTTTTGAAAATCTGTGATGCTCTGGATATAAATCCTAATCTTCTTAACCTCAAGTCTTTGCAACTGCAGAGCCCTAGCTCGCTCCCTGGGTTCTCCTTCCCATCCTGCAACCTAAGCATTAAGCCAGGTAATTGTAAGAGTACCTTTCTATTTTTTTTTCTCGGATGACTGTTGTGTGTCACCTATCTCCAGAGCATGACAATCGTTTTCTCGTGTGTTTTGGCTATTTATTCTAGAGGAACCGTCTAGGTCTATATTACTCCACCATGGCCTGTGGTGGAACACTGGTGTGTTGTTTACTAGGCTAAACCCTTCCTTCATGATTCATATAATAAATAAGCATGATGCCTTTCTCCAGATGTGAACCTGGGTTACGTGTAAGAAGTGCAGCCGAGGTGATGGTCACTGATGTTCCCACGACATGAGCCTGGCCTCCTAGCGGGGGAGCAGTCTGCACAAGAGTGAGACCCAAAAGGGCAGACACAAGATCTGTTAGACACAAGGACCTCCAAGCACATTAGCACGTTGGCTGCATAATGTTTGTGATGCTCCCTCCGTTCAAGCTTTCCTGTGGTCAGCACGCACCTGCTGAGGACCCACATGTCAGCCTGCATTCTAAGACCTGGGGATCTCTCTCCTCAAGGAGCTGTGGAAACACAGCATGTTGACTTCTCTGTGTCCCTGTAACTCACTCCACATCTGGCCTTCTGTGTGTGTCTGTTTCCTTCTGCCTTCACCTCTTCTCCTCCCTTTCTCCAGTTTATATGACCTTTGCACAGTAGCTTGTTCTCATGTGTGCAGGCAACTTCTCAGATCTCTTTTATTGTCATTTTATATTACATTTACCGTGTGTGTGTGTGTGTGTCTGTGTGTGTGTGTGTGTATGTGTATTTCTGCTTGTCGGGGGAGCCTATCTGTTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTGTGTGTGTGTGTGTGTGTGTGTGTGTCTGTGTGTGTGTGTGTGTGTCAGTGTCAAAGCCCAGAACAACTTGTCCAAGCCGCTTCTCTTCCCCTCCTATGTGGGTTCTAGGGATTGAACTCATCTCACCAAGCTTGGCAGCTAGTGTTCTTACTGACTTAGCCATCTCACTGACCTGTATCATTTTCTTCCTTCTACTAATATTTATTTTACTTTTAGAGTAAAAGTCCTTACAAACATCTATATGGCTCTGAGAGACCCAGGCCCTGCACTTTTCTCTTTGAGTTCATCTGTCCCCTCTGACTCTGCTCCTTACCCTCAGCCCATGTGCCACCTTTCTGCCACTGTCAAAAACAGCAGAGTGCCCCTGCCATGCGGTCTTCACATTCACCAGAGTCGTCCTGCCATGAGGTCCTCACACTCACCTGTCTGCAGCTCTGATACTTAGAATCCACTTCTTCTGACCTCCCTCAGGACTGGCTCAGCTGTGATCTCAGGGTCCTGTCTCGGTTCTCCCTGTCTGGCTCTCCTACCCTCTCACCCCTCCCAGGCCTGTCTTCTTTTTCTTGTTTACATGTATTTCTCTTTTAAGTTACACTGTAAAATCTATCATCGTGTACCCTAGCATGTGCATTGTGTGAGAGCACAGTGAAGCCACACAAGCCTTCCCTAGTAAAGCATACGTACAAGGGCACCCGTACTCTGTGACTCCTGAGTTGACATCTAATATCTTCTGAGACGTAAGGTGATTCAAGTTTTCCTCCAACTCTTTTAGTAACCCACTTTAACCTGGTCTGACAAATCCACTTCTGTGATGAGTCTGGTTACAGGCCTCTCTGCACAAATGTCAATGAGCTGAGTCCATGGTCCACCCCAGCCCTGCCAACAGTGTCTAGTGACGTACACCATATGCCATATATCACCCTCATAAAGTCCCAAATTCTGATGTTCATCTGACTTTGGTCTGTGTAAGATGCTGAGTGCTTGTGTACTTTTTTCGGTGTGCTGTCTGCTGACCTGAAGCCCGCCCCCCGGCCATCACCTGCCTGACTTCTCCTCTCACTGTTTTTCTCCAGCTTTGCAAACCTGGGAATACTTCATCTGACTAAGAAAAAGGTATTTGAAACACTGGAAGCACGGATGACAGAGGCGTGTATTAGGGGCTATAATCCTGGACTTCTGGTGCATTCTGACCTTGCCTATCTACAAGCAGAAGGCGGAGGAGACCGGCAACTCACAGGTGAGCCAGCTGACCCAGCCTTAATTAAGGCTTCTATGTTCCAGGATGACTGCAGCCATCAGCGTGCCAGGCTATCAGAGGGAAGGGGATCAGTGCAGCCCGGTCTTTCCTTTCTGTCCTGGTTCACCGTGGAGAAGCCGAGCCCACACACAAGACTCTGCATGCTTGTTCTCACCTATCTCTCCCCACCCGGCGGTGCAGAGACGTGCATTTCCCTGTACTCCTCGCATTCTATQTCTGCCTTAACTCTTACCAACCGTAGGAGAGTAGATGGGTGAGCATCGCACAAGACAATATTTACAATACTCCAGACAAAACGCAGCTTACCTTTGATGGGTTTTTACCCAATTTAATAACACCATTGTGTAAAATTTTACTAACAGTTTAAAGAATTTCAGGCCAAAGTAAACCAAGAAAAAAAGAAGACTCAGTTATTAAAATTAAAGGTGAAAATCAGGGAAACATTACCAGAGGTAATGGTCAAATCCAAAGAATCATTAGGGCTTTGAAAATATGTATTACAGCAAATTAGAATATCTCACAGAAATGGGTAAGTTCACAGGTACATCTGACCTGCCAGTGTTAAACTAAGAAGATAGAAACAACTTACACAGACCTAAGACAAGCAATAAAATATCTCCCAACTGAAAAATACCCGGTCCTAAATGGAATCATGGCTGAATTCTGTCAGATATTTGAAGAGATAACGTAAATCCTCCTTAAACTGTTCCATAAAGTAGAAAGGGGAAGAATATCAACAAACTTATTTTCCAAAGCCAGCATTACTTTTATACCCAAACCAGGTAAAAGAAGAAAAGAAAAGAAAAGAAAAGAAAAGAAAGAAAGAAAGAAAAGAAAAGAAAAGGAAAGGAAGGAAAGGATAAGCCGATTCATACATTCCCAATAAAATAATAGATGAAATCATGATATACAAAACCGCAAACGGAAACACATCAAGAGCCCTATCCACAGACAATATTCTCCCACACACAACACCCCACGGCTGCACTCCAGAGGCTTAGCTCTGATTCACCATCAGCCCTCCCTCATCACCACACAGACCCCCTCGTTTTCCTATATCGATACTCACTCTCTCCACAAACAACTCACCAAACCCCACCCCCGACCACAGTCACACCCATCCCCCAGTAGATTGAATGCAATCCACAATGCCAATACCGTTCCTCCTAGAAAATAAAGTTCATTGGGACGACAAAAGGTCTCAAGGTAGCCAAAGAAACACATCTCAATCAATCATCCAAACCCCTCCCATGTTCCTCCGAGTTAACACAGTTACTACCACAAAAATATCCCCAACTCTCCTCTCTACATTCAATGCAAATCCACAXTCCCAATACCGTTCCTCCTACATAAAACTTCACTTGCCACCACTAAACGTCTCAGGTAGCCAAAACCTATACCATACTAACAATATTTCACACGTATCACACCTGCTCATATCAGAGGTATCATAGCTCCTCATTCCACCTCACACTACAGACCCATCCTAACAAAAAAAGCATGCAACTCCCCTCACACACCTCTATCACCACAACAGCAGACTCACAAAACCAAACACAAAAATCTACCCACCTCATACCCCAGAAACATGCCAAAATCTCCATTAGACAAAACACCCCCTCCACAACAACTCATCCCGCTCGGGAACCCCCTAGCACATATAACGAAGCCAACCAGATCCCACCCTCCTACCCTACCAACCAATTCAACACCCAGCACAGATCTTAAATGGACCTAAAATCCTCTCAAACAGCTAAAGGAAAACATGCACAGAAAAGCTTCCTCATCTACCCAACCCCTTTCCGAACCCCTCCAGCAACTCAGGTAATAAAAATCCACAACTAGCAACTCACATTCAAACCCCTCACAGCAGAGGAAACAGTTTCCTGAGTTGCAGAGACCACACCCTTCACTCCCCCAAAGAATTCTTGCTAGCTATGTAGCTGACAGATTAGTATCTAGGTTCTATAAAAACTCAAAAAAAATTAAATTCTGGAAACAAACAACCCAGTAAATAAATCCCCTCACAACAAACACACCCTTCTCCAACAACAGTCCAAACACCCAACAAATCTGATAACCATCCTTCACACCCTTACTCTTTAAAGTTCCTCTGAGGTCCCACCTCACCCTCCTCACAAGTCATTAACAAAACAACTCCACCACCCTGCCAACTACCTCACCTCCTACACTACTTACCTCTTCTCTAACAACTCCTCCCTTTCATTCCCACCACTCCCTACAAACCCCTCCACTCCCACATCACTTCAACGTCCTCCCCACATCTCTGTACCACATCTCTTACCACCTAACCCATACAAAGCCTGCTGCCCTGAATTCAGTCTCCACCACCCACATCCTACAACCACACAACCCCTCCCCTCACCTCCTCCTCTACCCTACACACCTGTCTTATCACCAACAATCCAACAATCTTATAAAAACAAAATCAAAAATGCACATTTACAATAACATCAACTAAAACTCCATACACACAGCTATCCACTCCTGCGCATATTTACAAAACTCTAACTCCACCTACTATAACATACATATTTCCCTCCACATATGTGTTTATTTCACCCATATTCAACACCTACATCAAACAACCACCCTACCTCTCCATTACCAGATCATCCATTAAGAAAGCATGATATACATCAGTAATGGAGTTTTTTTTTCAGCCATTAAAAAAAAAAAAACAAAAAACAAAGAACCCCTCCACAGATCCCTCAGCAGTTAACACCACTCACTCCTCTTCCACACCTCCTCACTTCAAATCCCACCAACCACATGCTCCCTCACAACCATCTCTCATCCAACTCCATACCCTCTTCTCTTCTGTCTGAACACACCTATACTCTACTCACATACATATAAAAATAAAATCTTTATTTTTAAAAAAAAGAAGGCAACAAAAACAAAACAAACATTTCCACCCCAGTGTATCCAACTGGAGATCTCTCTATCAACACAAATAACCCACAACAAACAACATCAACATCACCTACCGTCTCTCTCGGTTCTACATCCTACCTTTTATATACATCTACATAACATATTTTGCATATGCGTCCATACCATATGAAACTAACACCAACCTACTCCCTTCCTAGCCAGGGGACGAGTCCATATCACCACCGGACAACCCCCCTTAGCTACCCTCACAGTCCTTCTTCTAGCATGAAAATGTTTTCACCCACTTATCCCGATCACCACTCACTATATCCCAACAAAGACTTTAAGCAACTCTTTCTACACCAAAACAATTGCTCTTTCACCCCATTTCCTGTCAAATCTTCACACTCTCACCTCCCTCCCCATCACCACACTGTTCTCTCTGACCCTAGACACAGAGAACGACATCATCCCCCACCCACCCGTCCACCAGACCAACCAGATGGACCTGAGCGTCCTCCCCCTCATGTTCACACCCTTCCTCCCTGACAGCACTGGCAGCTTCACTCCCACACTCCACCCTCTCGTGTCACACCCCATCTATGATAGCAGTGAGTACTCCTTCCCAACATGGCACACTTTCATCTACCTCCATCCACGGCAGCGCCACCATGTCACTTACTCCCCACACCTCACCCCTCCAGACTCCCACCTACTCACATAGAGCCTCTAGTTTATTCTCTACAAACTTAATACTCCAGTCTACGGTAAAGGGTCAATATCCACTTAACCCTCTTAACAACATCTCTGCCAACCTAACACGTCTTCCTCAGAGAGTGCATTATATTCCTTACATGTAACACCAGTTTCTTACTATGAACACATGACTGTAACGATACATTGCTGGTGCTCTAAAAAAAATTACCTTAATTTTTGCACCTGGCAGCACGGAAGAAAAATTGATAGAAGACAAGTATCCCTCTTGTCTCTCTTTATCCCCAGTTTGAAATACATTTATTAAGACAGGAACGTCAAGGTAACTAAATAAATGAATAGTATGTCAAAATCATCTTTCAGCCTCCACATAAAAACAATGTGCAGGGTTTCCACTACCTTCTACAATTTACTCTGTCCCTCTATTCTTCGATATGCATTGGGCTTACAAACAGTTCTTTCACCAACCCTCCAACCCTCACTCAATCCTCATAGAATACGATGCACAACCAAATCCCATCTTCTCCATCCACCCACCCATCCCTCTCTCTGATTTAAACAACTCTCAACCCAACTCAAAACTTTATTCAATCGAAAAGAGTCTTACTCAACACACATCACCTACACCTCTTCCACTTTTTAAACCCCCAACCTTTGCCCCACTCACCACTATCCCCACCTTTCCCCCAACCACACACAATCCTAAATTTACGTTGCGGGAAAAAAAACCACAACATCTTCACTTTTCTTTCAACAATATCTGTGTGTGTGTCTCTCTCTCTAAATCTCTCTCTATATATATATATATATATATATATATATATATATATATATTAGCTTAAAATGTCATTTTCTTAAAATTTTTAAGAATTTTACAAATGCATAAGTTAGCATGAAACAACCCATTCCTCCACAAACATCACACACCTCTCTCCTTCCTCATCACCCTCTCTCTTACACACCCATATCCCACCAATCCCTCCCTCACCTGCTCCTTTCTGGGGAACCATCACTCCCCCACACCCAACAACTCCTCCTACTACCTTGCAAGTCTTTCTTCCTCTATTTCTCTCTTGTTAAAGGCAGTAAGAGTGAGCACCATCATGGAATCTTTGTGAGGCTAATGCTAAGCCAGGGTATGCATTCTCTTCTCCCTTTGAACAGAACCCCCGAATCCATCCAACCTCAAAATCCTGACAATGGACACAACAGCACGATGTGTGACCCCACCCCACCACATTTACCTTCTCTCTGACAACGTTCACAAAGGTACGTACACACCTCCTCTCTACATCTACCCTCTCCCTCTCACACTTCTCTCGAAACAGCGCACCACCCCTCTTCTCCTTTTCCTCTCCCACTCTCAAAAACACAGCGTTCTTCAACACCATTACACCCATTCCAATCACATCCTTCAATACCCCCCTTTCCACATCACATCCAGATTCCCTTTTATCAACACCAACAAAATCCCCCACTTTCCCAACCATTTGGGGACTTTTCCCCCACCCATCTTCATACACACCTACGTCCGTTATTATTGCGCGTTTTATTTTAATCCACTTCTCCCTTCCTCAAATTCACTCCTCACTTTCAACATATTAACAAACAAACCGTCATAACTCTCTTTCACATCCATACAGCAATGCTATGTTTATGGCTCTTCCACTACTCTCACATACACCCTCACAAGTCTAAAGGGCTCAACCTGATCCTGTCCTCATCACCTCCTCTCTCTCCCTCATTCCTTACATCACCACCGTCTCCCAGCTGATCACATCACCCACCACAGTAATAGTCACTCTTTGACAGTGACTGAGAAATGGTGTTTCAAATAATTGGCAACAACCCAAATGTTAGCCAGTAAATCACTAATTAGATAGTGGTGTATCTATGTAATGGAACATCATACAGTTACTAGAAAAGAAGGCTCTGTGAATGAACAAAGACCTCAAAATAGAATGCTAGATAGTGGTGTATCTATGTAATGGAACATCATACAGTTACTGAAAAGAAGGCTCTGTGAATGAACAAAGACCTCAAAATAGAAATGCGAGACAATAACAACATCACCTCCCTCTACCATCTCAAGTTAGTGCATGACTCCCAACCCGCCACCCACCCACAACTCTCACCATATCCTACCTATTGCTCATCCTATATTTGATGACATCTTCATCCTTATAAACATAGAAACACCCAAACTAAGTCTCTCCACTTCCTTATTATCCCACCACTCCCCACCACTACCATCTCACACCTCCTCCCCACCCTCACTTACCATCACTCTCTCCCCCCTCTCACCGGCAGCCCTCCTTCTCTCTCCTTCCACATCCACTCCTTCTCTTCCTCCTCCCACTGATCCTGGATGTTTTCAACCCTATCTCAAAACACAAATCCCTCACTCCCCTCATCCCCCATCATCCTCTTCTCTTTTACTTTCACCCCCCCACTATAACTCTCCCTATAACGTACTAACTCCCAACTTTCTCCACCTCCTCCCTTTCCACACACTTTATTTAAGTTCACAGTATACATACACCTCTATACAATCTCCCTCATCCTCACCCACACTACAAAACAAATCTCCTACACTAATGTTTGGGTCTTTTCCACCCTGCAGTTTGCCATTCTCTTCAAAACCCCAAACTATAACCATCTCAACATTACAAACCCAGCTTCCGTGTTTGTTCAGCTTCGGAGGAAATCAGACCTGGAAACTAGTGAACCGAAACCCTTTCTCTACTACCCTGAAATCAAAGGTACCTCCCTCCTTTACACTCTTCTCCTTCCTCTCAAACACCACTCCCCCCCTCCTCTACTCACCCTCCCAGAACCTGCTCCCTCCATCCCTCGATGCACCCTCCATACTCTTACCCCCAACCAACCTCATATGCCAACGTCATCCAATTACCCCCACCAATTTATCTTACTATATTCCTCCCAAACTTATATGAGACTTACACATTTCCCTATTCTTCCCTATTACAAATCTACTATCGACCCAGCAAACATCCCTAAACACTTCCTCTCACCCCTCACCTCACCCTCACTCCCAAACCTGTCTGCTCAAACCACACACCTACCTCCCACAACATCTCCCTCGTCCTCCACCACCACCCGGCTGGGCGGGGAAGAAAGGGAAAGTAAAAAAAAAAAAAAAAAAACTAACCATTTTTTCACCTACTCACAACCCCTTAACAATTAACCAGAAGGCTTAGCCACTGTCCAGCCCAGAACTATTCAAAACATCCTCACTATACTTTCCTCACCACACCTCACCAAAAAAAACCTCCACTATACTTAAAATCCACATTACCATTCTTTTTCACCTCCTAGACATCATATTCTCTCCCCCTTCTACACACTACCCACCTCCTCTACCATTCAGCTGTAACCCTGCTTCTCAAATGATAAGTACCCTGGGAAAAGCATCCACAAACTGTATCAAATAGTTCAGCAGACACTCCTGGATTCCTTGGTCTAAAGAATCAGCCAAAGAATTTCTCTTCAGTGGGAAGCCACTTACCACATTATGAAGGTGAATGGAAGTCAAGGCTCTGTTTATGAAGACAGATGTTCAGAGGCAGAGGTCTGGCAGCTCGTGTTTGTCCTGGCAGAAATCATTACTGTGAATCTCTCTGGACTCAGGGAAGGTTGATTTAGGCGAGGGAGGCCAGGTCCACGCACTGAACCGTTTCTCTCGTAGCTGGAGGTTTTTGCTTTGACTCTGATGGCTAGCCCTGCCTGCTCACTAATCTCCAATGATGTGGTCACAATGTTGCTAGAATTCATGGTGCCTCAGCAGAGTTACAAAGGGTTCTAGCAGCCACAAGTTAGCATCCAGCAGATACTTCTATGTTGGTCCTCTGGAGACCTGGACCTTGCGTCAGAGAAAGGAAGAGAGACTCAAACAGTCTCAGATTGTTCTAGGGTTTCCAGAACTAGAAGTGTATGTATGGAGTGGTTAAGTGCATAAGAGGAACAAAGAGAAGAGTCTGAGAATGAAAGAGAGCTTAGTGTAACATATTTCAGTTGGGGTCAAGTGCAGGAAGGGGGCCAGTCAAAGGCATGACTCAAAAGTGGGTGGGGGCTCAGCACTGAAGAGATCCCGGCCCCACAGAGTTTAAAGTGTAGGGACGCACAGTGCTGCCGTCAACCTCTCTGTACCTCTGTTTCGTAAGTTTTGTCTTGACGGCCATGGTTCTGAGAAGAGATCCATGAACTTGGAGGCTACACAAGGCCTGGGATCTGATTAAATCAGAAATGTCTGGCTCAGAGAGAATGGGGCTGGAGAGGATGTCACCAGGTACAGGGTCCTAGGTCCAGGGCCACCAAGGCCCCCAGGTATCGGTCCCTTGAAGGCAAAGCGTGATGGTGGCCAGGAGTTTCTGGGAGGCCATGTCTCTTTTTGAGGTATGGCCTCCCCATTCCTGGGTCAGGCTTATGGTGAGCTCTGTGGCTGGCCTACTTCCTTCCTCACCAGCTTGAGGTCTTCTAGATCCTTCTGTCCAGACGCAAACATGATAAATTACTGCTTTACCTGAAGCCTCTGCCCTCTGAAAACAGGAAAAAAAGATTATTTTTCTAAGAAAAAAAAAAAAAAAAAAACAGTGTATCTCCTGAAATGTGCCTTTAAAAGAGCGTTGTCATTGCTGATGCAGAATCATGAGAAAAAGAAAATGAACTGAGGTTCCCTGTGCAGGATGTGAGCCTTGAAACGCTGAGAGTTTGGTTGCCAGGCAACCTCTCCTGCTAGTGTCTGCATCTGAAGAGTACAGTAGACAAGGCCCAGCTTCCTGGGCACTCCACGCCAGCAGAGTGGGAGTTTTCTAATGCCTGGATTAGAGGATTGGGGTTCCCTGAAGTCCTGGTTACCTCACATCTTCTAGGTCATCATGAATACAAATGGTATACTTGAAATACAAATGAGGCTCCACCTACACACAGGATGGCTGAGGTACCTGTTGTGTTCCGTGTTTCTACACTGGAAACATTTTCTCTGTGAGATCCACAGTTCATCCACTGACTAAAATGAATATAGCTATTGGTTTTGGTATAACTGGTGGGAAACTTTATAAATATTTCTCCGAGCCATCAGTTAGAAAGTAGACAGTCTCTTCACCTCAGCCTCACTCCTTTCTGGCCGAAAGCCGTTTTCTTCCTAATCATCCTGGTGTGCCCAGGGTTGGTTTCCCAGGGACTGGCAAAGTCCACCATGCTCTCCTGCTTTCCCCATCAGCTGCAGTAGACAGTCCAACATAGTCCAAAGTCCTTGTGCCACACCGTGGGGTGATGGAACACCCACAGAAAACTAGAGAAGTAGGCATCTTTCTGAACATAGACCATGATGAAAGCCAGCATTAATCAGTCAGACACAGGACGATTGTTCAGTATTGGCCTATTTCCTGGATAGAAGCACCATGTTGAACTATTTAATGTAAACACAAAACCACCTTCACTTCTCAGCCCCAAAGACAAAGAAAACAAACAAACAAATATCTGCTAGGATACTCCCAGACCACAAAGGAACAGGAGCACCATGTCAGATCTCCCACACAGTAACAGGACTGAGAACATGGTGGCTGAAGATCACACGGGCCATGACAGAACTGAGGGCACATGGCTGTCGATCACATTGCAGTAACAGAATTAGGGGGGCTGTCTGGGTTAGTAAGGAACACAGACAGTGAAAGACAAGAGGAACACAGAACTCTGTGAAGAGCACCAAGATAAGTCTCGGAGCACCTGGACCTGGGCAGGCCACTGTCCCAGAGGTCACTCACTGTCCCAGAGGCCATCTTTATTTTGGAGTCCGAGATCTCAGGAGCCAAAACATCTCTGTACACCCTCTCTGTGTTTCTAGGATCGACATTATATCTCTTACCACAATAACCAGTAAGGACTCGGTCTCCATTGCCTCATGCCTGCACTGTCTTCCTTAGAGTTTGACTCTAGATGTCCTGTATACAGTGATAGATGTAGCTCCTAAAATGCTGTCCTCTATGTCATTCTCTGAGACATTCAGCAAGTCCCTCACATTCCTATCCCTGAGGCTCCTCAGCATGGGTGACCCCAGTCCTCCTTTAACCTTTATTATCAAAAGCACCCACCCATGTTATCCCTCTGAGAAGCCCTGTGTCTTCCCAGAATATCATGTTCTTCGGCCATAGTTGTTAGCCTTTATAGAGGCTTGTCATGCTGTAAATCTGTTTTCACGTGATTTCACATGATGGTATGATGCATACCACCATAATCCATCCCACTAAATCCCTCTTTGCCTTGAAATTGACGGTCCTTGACAGCAGAGATGTGTGTTATGTTTCTGTCCATCCCAGCACCTTGCTCAGTGTATGTACGGAATAAATGTAAGCTGGTTATTATAGTTGTCTTAGGTGAACAAGGACAACTGTTCTGAACGTTAGCTGGGTGTGGTGGTGCACACCTCTAATCCTAGTGTTCACGAGGCAGGCAAATTTTGAGTCTTGTTCAAAAACCAAGCTAGTCTACATAGTGAGTTCCAGGCAGCTAGAGTTACATGGTGAGACCCTATCTCAAATAAGAAGTTAAAGTGCTTTAAGAAAGAAAAAAAATATGTGTATCTTTGGGTTATCTGAATCTTGAGAAGCAATGAGATCTCTCACCATCTTGTTAGCACTGGGAACTTAGGAGGGGGCGCTCAGGAGAGTTGGGTGTGTGCCGCACTGTGGTCTCTGAGGCGTGCTCTTGGTCTTCTCGTCCATTGGAATATAAACCATGCTTCCTCCTCAAGTGCCTGTTATTTCCCTTTAATGCATTTAAAAATATCATGAGAATCAATCGTCTCTCTGCGGCTGCTGGTGGAACCCGATCAGTCTTTCCCCCCTGGTTTCCCTTCCTGTAAAATACAGACAAAGAGGAAGTGCAGGAAACGCCAGAAGCTTATGCCGAAACTTCTCGGACAGCTTCGGCGGCGGCAGTGGAGCGGGAGCCGGTGGTGGAGGCATGTTCGGTAGTGGCGGTGGCGGAGGGAGTACCGGAAGCCCTGGCCCAGGTACGAGAAACATCTCTTCTATCTAAAGCCTTTCATGAAGAGGAGGGGGTAGTTTTCTTTCCCAGGTTGCCAACAATGTCTGCCCATGGAGTGATGGTGTCATTACTAATTATTAGATTTCAATTAATGGAAAATTTCCTACAGATGTAAAAAATTTTTTGTTCTCAAAGAAATGTATGTCCAACTCAAGGCACAGCCACTCCCCACCCACCCACCCATCAAGTTTCACTTTCTGTGGTTTCAGTTACACGCGGTCAGCTTGAGTCTAAAAATATTACCATTGTGTTGACAGAGAGAGACCACACACACAAAACTGTCTTCACAGTCTGCTGTTGTGACTGCCCTATTACTCTGTGTTCTTGGTCTCCTTCTGTCTTTTTACGTTGTGAACTTTACCCAGGTCTGTATGCATCTGCAGTTTTAGGGATACACTGGGGGTCTCGGACGTTCTCTTTCAGGATAATATGTGTCTAGTCCCGAAAAGTGTAAGAAAAAAAGTCAACTGAAGGGTTTCTGGAAGAAAACCTTTCTCAATCATTTTTGAGTGTTTCCCTCCTCCCCCTCCCCTTTGCTTTTGGAGAGCAGTTAGTCTATTATTCTGAGATATTAAAAAAAACAACTATCATACCCACCGCATGGTAGATGGGTATAATATGCCTACACAGCATACTGTGGGCTGGAGACACTGTACTGTAACAACTGAGTCAACAGAAAAATCATGCCAGGGAAGCACTTCAATGGTGTGTAAACTACTGCTCCTAACTGCCACGCATACGGCACAGTCAGTATTTATGTGTTCCTCTCGGGTCCGGCTATGATCCCCGTGCGTGGATTTCCAGCCATCTAGTTACACTCAGTTTTTAAGCATCGTTGCATCATGCTTGTGGATGCTGAGTACGCTGCTTTTGCCTCAGATCTAGCTAGCTTAAGCATTTCAATGGAAATACAGTTCTTATAGCAGCATAAGTGTGCTGTTTTAATGACTCACACCTGTAGCGTAAGTGACTTGAATGCTGTTTCCTGTCTCCTGTGTAAAATAACTGTGCTGAGCATGGCCTTTCTTTATTCCAGATAACATGTAAATGCTTTAAATGTCAGAGAGTGTAGTGCTAAGTGCTGGCTGCCCCTCTAAATTTATCATTCATTTCTCCACTAAAGTATCATTATATTACGTATTGGGTTCTTCTCACCAGGGGTCTTCATATTTAACTATTTTTTTCTGTAGGTCTAAGTCTTGGTGTGAGTACTTACCGTTAGCTTTTCCCTTCACCTGGAAGAAAGGGACCTGCTCAGCCTTAAGTCCTCCAAGCTGCTAGTCTGGGCACTGCCTGTTTGTTCAGCTGTCTGTTTCCCACAGTGATTCTGCTAACTCTCGGGCAGAGCCAGCCTGTGTAGGCTTGTGCCTCCCCATGCCACAGCCTGCCTCCCTGAGTGGGTCCCCATACTGTTAACAATCTCCCTGATGTTCCCTTTGTCTCATTGCTGGTTCAGGGTATGGCTACTCGAACTACGGATTTCCTCCCTACGGTGGGATTACATTCCATCCCGGAGTCACGAAATCCAACGCAGGGGTCACCCATGGTTTGTCGGATCGGAATACCCAGAGCACTGCTCGGGCAACAGGATCATCTCTAAAAGCTTTGGAAAATTACTTTCCAATAAATTAATATTCTCAGGTTATTCTAGGACAGCATAAGGGACACCCCTGACACGTATTTGCTCATCACATTGTGTGGAAGCAGGACAGAGGCTCTAGACAAAAGATGAGACTTGACTACGCAAACACACAAATACCACCTTCACATCTGTCCCTTTACCCCAAGTCCTATCCTTCTGAAATCAGTTTTCATTTTGTAGGGTTGGCCTTTTCCCACTCTTGGGCATCCTCTGAGTAGCTGTGGCTACAGGCTGCTCGTGGTTTATATAAAGCTGCATTCTTCTGTACCATGGAAATTATTCTATAAAGTCTTTCCATATATAATGCCAATTCATGCCAGATGCGTACATCACTGTAATCTTTTTTAAAGATTTTTAACTGGCATTGTCGTTTATCCTATAATCGGGTAACCATTCATCCCATAAATAGAACTATTCTTTCCATTACCTATAACCTCATGACCCCTGTGCAAGGCCAAGTGCTAGGCTTGGCACCTTCTGGACAGAGGTGAGGTTCAGAAACTTGACTTTCAGAAGACACTGTAGCAGGATTGGGTTTTGCTCCAGGTTTGCCCAGGAGTCTTACTGTCACTCTGTCACATAACGAGGTTCCTACAGCAACCACAGTCAGTCTAGTGATGGTGCCCTAGAGCCCTCCTGGCCACACAGAATGGAAATGAGCTCTGCTCGGCTCCCTTTCCCTTGCCACTCAGGATTAGGAAAAGAAATAACTGCTTTCGAGAACTTTCCAACTGGCTATCAGCGCACAGAACTTTAATCTCATTTTTCTTCTTCACAGATAACAAAATGAGATCCATGCCTTGTTTCTGTTTGGTTTTGTTTGAGAGAGAGAGAGAGAGAGAGAATATCACTGTGTAACCTTGACCTTCTGGGACATTGTGGGTGGAGCTCACTACAGCTGGCTACAGAATGAGTTTTGGGAAGGCAGGCTTTTAAATTGTTTCTGAATATTTAAAGTATTTCCGAAACATCCCAGGTTTTTTTGGTACACACCTTTAATCTCCACAACATATTATTTGTGTTATAAACATTTATAGTTTTCCATTTCCTCCACATAAGCCTTCTTCCTATTTTCCTTTTTTCTCCCATGTCCAGAACATATTATTTGTGTTATAAACATTTATAGTTTTCCATTTCCTGCAGATAAGCCTTCTTCCTATTTTCCTTTTTTCTGCCAGATTGTGCCAAGAGTCATGACGAGGACAGTCTGACTCTCCCTCACAAGGAAACTGAACGTGAAGGGCCCACCCTGCCCATGCCCTGCACCAAGACGGAACCCATCGCCTTGGCATCCACCATGGAAGACAAGGACAGCAGGATGGGATTTCAGCCTAGGTGACCTTGCCCACGAGGGCTTCCAGGGACAGCTGGGGTGGGTTTCACGCTACGTGACCAAAGCCCACAAGGGCTTCCAGGCACACCTGGGTACGGGCAATTCTAGGTACAGGAAGCTGTCTCCAGAAGACAGGTTTCCTTCCTGTTAATCTAAAGCTGATGAGTCAGCATCTCCTCTGAGTGCTCTGCACCGTGCCCTGTGCCCTGCAACACAAACGCCTCCTGTGGATCCAGTCATCTTTGCAGCCTCAGCTCTGATTATAAGTGCAGAACTTGCATGTACATTCCCTAGTCTGTGCAGTTCTGGGTATGAAAAGAGCCAACTCACTTTGTCCCTGGCCCAGGTAACAAGTCTCCATGTCCTTCCCGCACCTCCCTCCCACCACCCGGCTCAGCTCCCACACTGAAGACGTTTGCCTAAAGAATCGCACTTTTCCTTTATTCTCTTGTCCTCCTTCAAAAGTAGAATTGAAAGGGAACGTTCCATCTCACCAGGCCTCATTCGCATATGAGTCATGATTCTCGATCAGACGCCATCTGTAAAGAGATAGTAACTATTTACACATACTGGCCGTACACATGGTTACTATCACATATTTTTTTCCCTTTTTCTGTTTTTAAAAATACTTCTTCTGAGATGCACACTATATGTGTACAGAGCCATATGGACAGGGTAGATTTGCCCATTTGGGTTGAGCTTAGTCTGCTGTCCCTTGACCTTAAAAGATAATAAAATTTCCAAAACCCCTGGGGTTTCTGAGACTCCCTGCCACCCAAGGGTGTGTTTCCTCACTTTGACTCACACAGGATTCCAGAACAGACTTTCTTTGTAAAGTGATTCGCTATTTAAAATTATGGCAAAAGCCAAGTACCCTGAGATTGGTTGCTCCCCTTCAATCATAGACACTGATTGTTCTTCTCAAAATAGCAGATTTTCTAGATTGTTCCTCACAGACACTTTAAATCAACCTCTTAACTAATATTAATCTGTCAGTCAGACAATGCCCGAAATCCCCGATTGTGCTTGTTCTAGTCAAACACAAATCCAGAGGCAGCAAAAGGAGCATTTTCAGCTAATGCTGTGCCATGCCGCACACGCGGGGCGAGCAAATGACACTCAGCTGTGCTTGTGGGCATTACCTTCCAGATAACCTCTTTCTCGAGAAGGCTCTGCAGCTCGCCAGGCGACACGCCAACGCCCTTTTCGACTACGCACTCACGGGGGATGTGAAGATGTTGCTGGCCGTGCTACGCCATCTCACCGCCGTGCAGGATGAGAATCGGCACAGGTGAGTTGAGTGGGGACTGTTGCACAGCAAGCTCTGTTTCAGGACAAGGAAAGGCAAGGATACTCCCCCCACAACTGCCTTTGAAGGCAAAGCTGCCCTCATCTGACAAGACCTCGAGTATGCTGTCTCCCTAGGCAAGAAGGCTCAGATGTGTGTAATCATGCTAATTTTACACCCCTGCTTTGTGTACTAAAATAGTAAATTGAGAAAATTATTGACAGCCCTGCAAGTCCCTGAAGTGTTATTGTCATAGTGTACCCAAGAAACCCAGGTAAGAACAACATTAGTAGAGTAACTAAGAGGAAATGCCATTCTCTCCTAGCTACTAGCTGCTTCTCTGTGGCCTCTGTTAAGGGTCACGAGGATGTGAGTGGGTCAGGCTCTGCCTCAGCTCCAGGCCAGGCTGTGTGGGAGTCTCACATTCCAGATGCCATGCCTGCTCTCTCTTCCTGAGGTTCTGTGCACATAGCTACCTGGCTCCTTCCTAAATGGTTCTCTTAGTCCTTCCATTGAGACTTCTGAAATGATCTAAAAGCCTATAAATATAGCCAGAGACAGCAGTCTTGAGATTCAAGTGCTTTATCTAAGTGATCCTAAAATAGCGTTAACACTGAAAGAAGCCCTTTGCTGTGGAAGCATTCTGGAGTGCTGTCTGCTGAGTCTCAGTTTAAAAAAACAAGCGCTTTAGGAGAATGCCAACCTCAGGGGTTTCGTACAAGGACCTTTGTCCTCGTCACTTGCAGTGTAACTAAGGATGTGGTATAACCGCTGGTCTTATCCTACACAGTACAAGAGGAACCCAGACGACCTTCTGTGAAAAAAGCTCTGAATAACAGAAGGCGCCTTTAGAAGGAAATCATCCAGTTAGCATTCAATAGCAAATAACCACAAACAGAGCAGATAACCAGAGCAGGACACCGGTGCTCCAAAAACGGTCATCTTTAGGACTGGCGAATTCATGAGTAGTGAGGGCGAGTGGATTAAAGCAATTAGCAAGTGAGATGCTGCTGTCTGAAGGAGAGGCTGTGGAAGGGATCCCAGGCACATGCAGTCCACCAAGTGTGTGCAGAGGAATGCAGGAACATGTGTGTAAGGACCTGGGTGTTCATGGGGCAGCTGAGACACTGGCCTTCATTCCCAAGTGGGTACAATACCCAGACCCTCGTCAAGCCAAGACTTAAACAAGCAGGCTCCGTGTAAGGTTAGGGGTATCAGACCTGGGAGACACAGAGGACCCACTCAGGAGTATACATAAGGGACTATTCTGGTTTCTCTTCTTTATTCATCTTGTCATATTTGGCTTATAATCTGGACCCTGTCACCATTAGTCATCATAGAAATACAATAAAGAGAAACTATAGAACCCTCTGCTATCGGGGAACTTCCCCCAGGGGTATGAAGATCTGAAGGGGAGGAAGACGTGCTTCTGTGAAGTGCTGAGCTGCACATGGAATGTTGAAGTAGCTTTTCAAGCCCTTTTACTCGACGTGTGTCTGTCCGCATCACCTCTCACAAGCCTCCTGTCAGGGTCCCATCAGGACCACCACAGGAGCCTGAGGTGTGGCTGCGGTGCTTCTCGTCAAAGCGTGCGTGCTTCACTTGCAGTTAACACAGGCCTGGGGTCATCTAACAACGCCACCATGATCTTCCCTGAGAAGTATTGCTAAGTGAAATATCTCAGGGATATAAACAAGACCTTCTTTAGAAAATAGAAGTCACTTCTCATTGTTACGGAGAATAAGACCTCGGCAGCTGAGTTTTCCCAAGCTGCTCCTAAGCCTAGGCATTACCTTTCTTCATGGTCTTGTATGTCAGGGACAGACCAGGGAGAGCTGCCAGGGACAGAGGCATGGAGACAGAGCTGGCTTCGAGCTTAATGCCATTTGGTTTCCGACCCGGCAGGTGCCTTTGCACTTCATGTGTCTGGTCAGATGTTAACACTCCGGGGGCAGGTGGGCACGATCAGTGTGTAGTAGCCTGCGATAGGCAGTGGAGAGGAAGTTCTCCAGAGAAATAATGTCACCTCTGATCAGTACATTCAGTACATGGTAGGGCCAAGGAAAGCTACACATAGTAGCTAGTCTTCAGCTCCAGTCATTTCTTGACATGTTTTTGTTTCTGTCGCTTGCTACATCCCCAGTTAATTATTGCCACTGTGTGTCATTCCAGTGTCTTACACTTAGCCATCATCCACCTCCACGCTCACCTTGTGAGGGATCTGCTGGAAAGTCACATCTGGTTTGATCTCTGATGACATCATCAACATGAGAATGACCTGTATCAGGTAAGCAGCCACCACAAGGCCGTCCACAAGAGAAAGCTTGCCTTAGTAAACACGTGCGTGAGCTGTTCTCACTGATGCGAACAGGAAAAACAGCATCTTCTCAGAAGTGGCATCTTAAAAGCATCCTTAGTTGGCAATGTCATTTTACAGAGAGATGGGTTGGGATCATGGGTTTCATGCCAATCACACTCCATCCAAATTCACCATCTTCTAGAAAAAAGGCAGACTTTAAGACCTAGAAGTCACAGTTGATAAGTTTTGAGGGCAACCTCAGAGGGGAAAAAGTCACAGCTGTCACGAGAGACATGTTAAAAAGAAAATCCAAGTTTCAAAAGCCAGAGTTACACAGACAAGTTTGGAGCTGAGATCAAAGGATGGACCATCCAGAGACTGTCCCACCCGGGGATCCATCCCATAATCAGCCACAAAACGCAGACACTATTGCATATGCCTGCAAGATTTTGCGGAAAGGACCCTGATATAGCTGTTTCTTGTGAGGCTATGCTGGGGCCTAGCAAACACACAAGTGGATGCTCACATTCAGCTATTGGATGGATCACAGGGCTCCAAATGGAGGACCTAGAGAAAACACCCAAGGAGCTGAAGGGGTCTGCAACCCTATAGGTGGAACAACAATATQAACTAACCAATACCCCCAGAGCTCATGTCTCTAGCTGCATATGTAGCAGAAAATGGCATAGTCGACCATCACTGGAAAGAGAGGCCCCTTGGTCTTACACTTTATATGCCCCAGTACAGGGGAACGCCAGGGCCAAAGAAGCAQGAGTGGGTAGGTAGGGGAAAAAGGGCGGGAGGAGGGTATAGGGGACTTTCGGGATAGCATTTGAAATGCAAATGAAGAAAATACCTAATAAAAAATTGGAAAAAAAGAATATTTTCAAATTAAAAAAAAAAAAAAAGAATTTTGAGGTCTGCGGAAGGAAGGGTATTCGCACAGCAACTGGATCAAGTCTATGTCAAGAAGGCTCTGAGGTCAGCTCCTGGAGAGGTGAAAGGCTGTAAGAACAGGAAGAGGCACCTCAGAGTCCCATCCAGCTCACCTGTGAGAAGGTAAGGGAGCCCCGAAAACTCCAGAGGAACCACCTGGAGATGGCACAGTGACCTCAGGACAGAGGCAGATGGTAGGGGAAGCAAAAACCAGAAACTCCACTGGCAGACACACTCTGGGAGCTGTGGCCTGGCCCAGGATGGTGACCTGCTCTACGGCTCCTTCCTCTCTCACCTCTATTTCTCTCCAACCCTTTTGTGCCCCTACCCCTCTCTCTGGCCCTGTTGGTCTTATCCTCTTGTTGGCTTCTAAGTTCCTCTGCACTCTCTTGCCCAGAGTGTCATTCTGATCCCCACAGCCAGGCCCATGCTGACACCTCTGCTTCCAGGTCATATTGCTTTCATTGAACTGTAAAACCAAACAACCGTGAATAATTTGTTATTTAGAAGACATGAGATGAGAACTAGTGGAATTCTTACTTGTTTGTTTGTTTGTTTGTGATGTTTTTTGTTGTTGTTGTTGGTTTTTTTGGTTTGGTTTGGTGCTTGGGACTGTACCCAAAAGCTGAGCACCCCTTCCACCAAAATCTACAACCATGTTACTCCATTTTTAAAACAAGTTATTCAAGTTGTTATCTCTTCTTATCCATGCTTCTCTCTGTCTCCCTCTGTGTCTCTCTCTGTCTCTCTCTTCTCTGTCTGTCTGTCTCTGTGTCTGTGTGTATCCCTCTCTATCAAAATCTCTCTCTCTCTCTCTGTCTCTCTTTCTCTCCCTGTGTCTGTGTATCTCTCTCTATCAATCTCTCTCTGTCTCTCTGTCTCTCTCTTTCTCTCCCTGTGTCTGTGTATCTCTCTCTATCAATCTCTCTCTCTCATTCTGTCTCCGTCTCTCCCCCCCCCCCAATGTGTGTGTATCTCTCTCTGTTGATCTCTCTCTAGCGTACCCAGGCTAACACTGAGCCATCAGTGTCCTACCTCAGCCTCCCATCATAGGCTTGACAAGCATGTGCCTGGCATGTTATCTCATTTTTAAAAATTTAAAAAAAATCATTATTTTAGAAGAAATTAAAAAGAAACAAAGAGATGACTCAGTGGACGAAGTATCTGCTGTACAAGTGTGAAGACCATGTTCAGATCCCCAGACCATCAACCAGCCAGATTTAGTACCACACCCCCCCACACCCCGCCCCCCCCCCCCCCTCCCCAGTCACGGCAGCAGAACGCATCTTGCATATGCGGGGGAACGGGCGCGGACAAAAGACCCTGCCTTATAACCTTCCACAGGCAGGGGGCAGTACACACGTTCCCCTCTATACAATATTTTAAAGTTACTTTGAAAATATGAATTGGAGGCTCAACAAGTGGCTCACATCCTTACCCTTGAGTTCGTTCCCTCCCCACACCAAACAAAAGCTGAAAACTCTTACTTCCTTGGCCTCTACCTCTCAGACTTTTCCGTTTTCAGAGGAACACAGCTGCTTTCTGCACAGCACTCTCCACTTCTCTGTCTGCAGTGATTCCTATCCACCGGAGATGACTAGGCTACGTGTTATTTTAGATAATGTTCTTCAAGATCTGTCTTCCTCGCCCTTCCATGCCATCTTCGGATACTATTGGTATTTGGAAAGTCATTGGGCCCCGATTGAAAATTCTCCAAAACTTTTAGGCAGATGGCACTTTTTAAAAACTTTGTATTGATTCTCTGTGAGTTTTGCATCCTTTTTTTTTTTTTTTTTTTTTTTTTTTTTGGTTTTTCGAGACAGGGTTTCTCTGTGTAGCCCTGGCTGTCCTGGCACTCACTTTGTACACTACGCATCATCCACCCCAGTCCCACTCATCTCCCTGTCCCCTCATATCTGCCCTCTGCCCTTGCAGCCTCCCTCCCACAAAATAAACACTCAAGTAACAGGAAAGACAAAAACAAAAAAAGCATAGAGAACATCTCGATGTGGGAGCGATAGTGTGTCACCGGCCATCCCACAGTGTATCCCTCTGTCCACACATCTTCACTTCCAATGAGTCTTTGGTTCTCTGTGACACGGTAATTCTGAGTTCCCCAAAGTATAAGCTTTTATGTTATTTCAAGATTATGCTTATACTGAATTTACAATAATAACAAACATGTGGCAAAAGTGACAGCCTGAGAACTAAAACGACATACCCCGTGTCACATGCCGGAGAAAATCCGGAACAGAACGCACTTTAAACACTCACACTTGGGCTAGTCTAGAGAGTGGCTGGGTTCCAACACCAAGATCTGATAGTGACAGATGGTCACAGATGTACTATGGTTAGTGGAACATCTTTGCCGACAAATGTTTGAGATAATTTACAATAATCCAATACTTAGAGAACTCTATACTTTTCTGCCAAGAAAATAGTTATTATGTCATGCATGATGGTGCATATCTATAATTCCAGCCCAGAGGAGTCTGAGGCAGGAGGATTGTTGTGAGTTTTGGCCCATTCTGGCCTATACAGTGGGTTCCAATTTTGTCTGTATTATATTATAGGGTCTTGTTTAAACAACAAGAACAACAACAACACAAAACCAAACAAGCAAAGAAAAAAAACCCTCCAAATTAAAAAGAAACTAGTTCCCAAGCTGGGTGTGGGGCACACATTTGTAGTTCTAACACCCAAGAAGACACAGGAGGACTGACAGCTTCATGTCAATCTGGGCTACACAGCAAGTTCTCGCCCAGCCTCAAACACAGGAAGACCCTCTCTCAAACAAAACAAAGCAAAACAACTCCACAAAGCCAAACAAAGAAACCCAAAAGTTATGAGAATCACAAACGCTGCCTCTCTATGTCCTTGAGGCTAAGAAGCTGGTATGGCAGGGAATGTTTGTGCCCATTAACTGAGTCAAGCCAAAGGTGGGAAAAACTGGGGAGAAGGTCTGAGGGCTCCAAATCAGAGCAGCTTTGCCTTGAGCTCAGGGGAGAGGTTCCATCCACAAAGAGCTGGGTCGCACACAATAGAGCCTGCTTCCGCACATCCTATCACCAACAGCCAGCAGGGCTTCCTGAATCCAACCTCCAGCAGCCGAGGGAAGCAGGTTTTGCAAGAGGATTGGGAAAGTAGCAACTTCCTCTTCTTCAGTTTATTCTTATACTTGTGATGGTTAAAAATGCATTCTGCCACTTCTCTGCTATGAGGTAGCCTGGGTGCAGGGGTGATGCCTTCCTCCACCTCGCCTCTCACTACCTGTACACGCAGTCAGGAGAGCTGGCCTGGGGTCATGCAAGGGGGTGACCTACCCCTGTCCTTCACAGGCTTTCGAGAGCAGGCCTTGCATCTAGCCTGTGCTGCAGAGTAGAGAGGACCCTCGTGGAGGGAGCACAGTGAGCAGCCCTGAGGGTGTGAGAGCAGCACAACTGGCCCTGCCCCTCACTCACAGGCTGTAGTGTATGGGAGAGTGGCTCCTGCCCTTTGGGCAGCACAGTGGAGCCAGCTCTGGAGGCATAGGGAGATCCGACAGCTCCCTATTTCCAGATGTGACTGTTGCATGTATACAGGAAGAGTGCTCTTCCAGTGTTGGCTACAGACACCTGCTCTGGGAAGACATGTATTCTTTAGTGTGCTCACATGCACTCCACACGGTTTTATACATACATTTCCTATCCCACATCAGCCTTTCCCTTTAAGTTTCAATTTAAAATACTTTCTCAATTCATAATTTTTGCAAAATTCAACTGAGAGGACCTGTATATTTCCTGAGATTCAACCAGACGCTTACCTCCTAAGTTCCCCCAGCACTTACATCCTACTTAACACAATAATACAATTAGGAATTGCAACAGATTCTAGTCAGATCTCAATATTTGTATGTACTCATATGCATGGATAGCTCTGTAAGATTTTTTTTTCCTAAGCTGAACATGGTGGTATTGTGTTTTAGTTCCTGTTATTCAGGTAGCTAACGCAGGAAGAGTCCTTGAATATAGATGTTCCGATGTAGCCTGGAACAGAAGCAACACTGTTTCTAAGCAGAGTGAATGAATGAATGAATGAATGGTCAATCCATGTGCTTGTCCATGTGTATGTAGCATTCTACTGTGTCCCTGTCTTGGGTCTTCACGCTGTTTATCCTTTAGTTTCATAGACAGCTGGTTTGTTCTCATTGCTCCTGAAGAGAATGCTGTCATGTCCCCTAACTAGCTGCTCACTGTCCACAGGCTGTGCACTGCAGTGAGCACCTCCACTGTACCCATGGGTGCCACAAGTGGGTTTCAAGAACAGTGTGAGCCCTGAGCTCCACAGATGGATTCTAGGGATTCCTTGAGGCACGCATTTTATGCCTGTGTAAAATGTAACCCTTGGCTGTTGGTGGCCCACCAGCCACTGCTTCCCAGCAGGAAACTCCCTGAATGCGAGGTCGGGCAAGTCCTCACTACACACTAACCTGGGCTTCAGTCTAAGCGCCTACAACACAGACTGGCTGGCATTGACAGTTGGTGCTACTCTCTACCAGTGATCTCAGCTTTTTGACAGACACTTTTGTGATTGGGTTAGCCCCACTTGTTTCTCAAAACAGTTTTCCAATGCGTCCTACTTACAACCATCGAAGCACAGCTTTCAGGTCAGGGTAGTCAGAAGACCTCCCAGAGCCTATTATGCACAGTGCCTGGGATTGTTTTCTGCCTGAACTTTCTTAGGGAGAGTGCTGTATTGGCTAACTATCCCCTGAGGATCTGGTAGCACCTGTGATAGTATTACAGTGGAGCTTGTATCTGTGCGTCTCTTGAAGCCAGCCTGCAGCAGTGTGTTCTGGTTTAGCCTATGTACTTCCAGACCATTGTGGAAGGATGACATCTTTCTTGATTGCTTTCTTTTAATAGTCTATTTATGTTTTGTTGTTAAAAACACAGCATTGGTTCGATTTGCAAATGTATAGAATTACCAGCTATAGATAGATACCTATCAGAAATTCAGAGAAATTAAATTTTCTTCTACAAGAGTTAAAAAAATCATGTAGCAAAACGTATCCCATAACCCCGACTGTTGAATGCTGGTTCCCTCCGTGGGCCTTTGAGCCTGGCATGCAGAACAGGAAGCTCCTTGAGTGACAATGTCCCTACAGTATGACTCCATAACGTAGCCTGAAGCCAGGGGCTACAGACATCCCTAAAACAATCGCTCTCCCTCTCCTTCTCTGTGTAGACACCTCTGCACTTGCCCGTGATCACCAAGCAGGAAGATGTAGTAGAGGATTTGCTGAGGGTTGGGGCTGACCTGAGCCTTCTCGACCGCTGGGGCAACTCTGTCCTGCACCTAGCTGCCAAAGAAGGACACGACAGAATCCTCAGCATCCTGCTCAAGAGCAGAAAGCAGCGCCCCTTATCGACCACCCCAAGGGGGGAAGGTAAGAGCAGTCGCCTTGCTGGCTAACCGTCCCCTCTCGGCTGCAGCATAAGGGCTTGGCATTTGACAAATGCGTCTGACATGACTTTCACCATCAATACTCTCCTCGGCCAGCTGGAGTTTGTCATATCTTGTGGTTATTTCTGCTGTTTATTACAGCAAACGCCCTTAAAGAGTATTTGTGAGTATTGCTTAGTAAGTGGAAAAGCAAGCCCCAGCAAACATTAGTCTTTATAAAGCATCGTGTGTGTGTGTGTGTGTCTGTGTGTGTGTGTGTGTGTGTGTGGAGAACGTTTACATAGTAGCTCAGTGTCTCCCGAGAACACAGTGGGAGCTTGTGGCTTCTGAAAAGTAGAACAGTGGACCGTCTGAGGCTTTGAACACGCCCTGAACAGAAACCGGAAGTGCTGCGACCTGGTGGTGTCCCTCCTCCCCGCAGCCCAGCTCTGTCAGTCTCACCCACATCTCTGCCTTTGTTCGGCCTTAGGTCTAATCCCATCCACATAGCTGTGATGAGCAATAGCCTGCCATGTCTGCTGCTGCTGGTGCCTGCCGGGGCACAAAGTCAATGCTCAGGAGCAGAAGTCTGGGCGCACAGCCCTCCACCTGGCCGTGGAGTACGACAACATCTCCTTGGCTGGCTGCCTGCTTCTGCAGGTAAAGGCGTACTTGTGATCTTGACCTAAATCCCCCTGGAAGTTTTAGGGAAGTCTTTTCAAAGAATGACTCTAGGGCCAGCTCGCTGTCAGTATTCCACTGTCTGCTTTCTGCATCCCCAGCTCCAGCCCAGCTCTCAACCTGGGGATGCCAGTGACACAGCCAGCCCAGTATAGCAGTTGGGTGAATGATGTAACCTGAGGTGCAACGGAGATGTCGAGCTAGACAGTGGAGGAGAGAGCCCCTGCTAACTCTTTCTTTGTGGGCGCATTTAGCGTGATGCCCACGTGGACAGTACCACCTATGATGGGACTACACCTCTGCATATAGCGGCCGGAAGAGGGTCCACCAGACTGGCACCTCTTCTCAAAGCACCACGTAAGACGCTGTGGTCACTGATACCAGCAAAGCAACTGCCTGCAGTTCAAAAAACTGCCTGCGGAAGCTGCGGTTCTGCCCTGGGAAAGTGCCGGTAAACCACACCTGCACCCGGGCCACTCTGCAGCGGCTGCACTGGAGGCTCTGCTTGGCCTCGGGTTTACCTTGATCCTCACGCTAGTTCCCACTCTCTGGTTATCTACGTTGCCTTTCGGTTGTTGAGGTTTACTCGGTACCTATAAAATCTTGAGCTGTGTCACCTTCTCGTCATATTACAAGTCTCCCAGAAGGATATCTAAAGACTTCCTTTTGCAAAAAAAAAAAAAAAAAAAAAAGTCTCTTAGAAGCTGAAAGCATGGGAAAAGCAAATGAGCCCTGTATTTGTGTTACTGTGCACGAGGCACTAAGACTTGCTGGCCTCCACTGCCTTTCCTCGGCTCCAGGCACCATGCTGGCATCCCATATTCACAGTCTCCTTTACCACATCTACTCCTCAGTAACTCTCTGAGATAAGAACTGTTGCTATTAATCCCATCTGAGCACCAAGAAGGCAGACTACAAAGATGATC1AAGCCCCACTCCCACTCTCCCGGAAGCTGAGTCACAGCACCGCAGCCTGACTGCAGACTCTTATTCTTCACGCTGTCTTTCTTTCTGCTCTGCCTGGGGTTCTAGTCCTTCCTGTAAACCACTCAGAAACATTCCAGCTCATCTCCTGTCTCCGGCGCTTTGTGTGTTCAGTGTTAACACATGCTTGATGAGGTTGGCTGGCCTTCCGGGCCTGCCCAGACACACCTGATTTACTTCACAGGTTGATAAGGGAGGATTTGTGAACGACACATTCCTTATAGATTCACCCTAACAGCCCTTGGTTCTAATGTGTTGAGTCATTTTGGAAAGTCACTGATTATACTGGGGGAAAAAAAAAGGTTGTCTCTTACTCAGACACCTGAAATCTCAACATTCAGAAGGCTGACGCACGAGAATGCCCACAAGCTTAGGCTACCTTGGTCCACATAGTTCTAGCCAGAACAAACATACATAGTGAGATACTCTCTCGACAGTAAATATATAAATGTAAACACTTTTACTTGAATTCACCATGAAAAGGTAGCAAATAATATCTTGTGTGACATAAAGAAAACCAGACAAAAAGCCTAGCCCTGACCTCCTCGCAGTCACAAAGGTCACTTCAGCCACATCTCTACCCCTCGCGTCTTCAAACTCATTTCCCAGTCATGTTCCTGGCCATGTTTTGCTCACGTTATAAAACAGCAAGTGAGGCACCACAGACTCGCAACGCAGCACTCTTCCCCCAACTCAGAGGTTCTCTCGGCAGAACTGAAGCAAACACTTCATTCCAAAACGCTGTGCTGAGCCTGCCTGCCTGCCTGCCACTGTTGGCCAACCCGGAGCCGGACACCCATAGGTAGAATACCCAGGAAGCCATCACAGGTAACTCCACTAACATTAGGGTTACGTTTTATGTTCTCTTGCTGGGAGCTGAACAACAGCCAATATCCCCAAGATTTGTTACCACATTTTTTCCCCATAACAACACATCCTGCCTAGCATAGCGGCCTTGTGGTGTCCATTTCTCTGTTCCTTACGAACTAGAACTAGGGCCCCAACAGTACAGCACTCAAGGACACAGCTGACCAACCAAATCTGCTCCACACAAGTAAGCGAGAGTGTGACAAGTGTGTATTCGTACATCTAAATGTGAAGGTTCAGGACTTTACCCCTGTGGGTGCATAAATTCCCACCTACTAGTCCTTACCTTAAATGTATCCTTTGTACSTATAATAATAATAAGAATAATAATCCTGCAGAGTTACAAATCCCAGGAGTACTTGAAGTCTTTCATGTATTTACTTTACATCCTGATCACGTCCTCCCCTCCTCCCAGTGCCCTCCACATGGCTCCTCCTCCCCACCCCCTCCCTCTCTCTTCACAGGGTCCTTGGCTACCTACTTCCATAGAAGTGAATTAAAATTTTTTAAAAAGTTGTTTTAAATTTCAAATAAAATCAAAAGTTATCCTGTAATTGCCTTAATGACCTACACGTAACCTGTCCCTCGACATGGGAATCCTGTGTGTCATTGGAGGCGCACAAGCTTTTTCTTTTACACAACACTGTATTTCCCTGACTCCATAGGAGCAGACCCCCTGCTGCACAACTTTGAGCCTCTCTATGACCTGCACCACTCTTCCGAGAAGGCTGGAGAACATCACGGAGTGGTGCCAGGTACCACACCCCTGGACATCGCTGCCAACTGGCAGGTCAGCTCTGGCCAGCCCATCTCATGGGTATTTACGGCCCAGCCAGTGCCTCAGGAATATACAGATGGTCTTCTTGGCATGCTCCTCCCTAAAAAAGAACATGCCTTTGTTTTTATCAGGTCTTGTTACCGAGAGGGTCTTAATCTTGAAAGATGGTCTTCATCCATGAAAGATGAAGGTCCGGTGAGCCAGAGTGTAAACCTGTTTGCGTAACTGGATTAGAGTTCAGATATGAGAGGTTAGAAAAGCACAAAATGCACAGAACAGTTACCCTGTCACCACACCACCAGAGTTCTTGCCATTTCTGTCAGAAGCTAGCTTGCTCAGAGCTTAAGTAAGACGTTTCTGAACATAAAAATAAACTAGAAATTCTCTTGTGGATTTCCATAAACATATTAAAAACCTTCCTTAAAACACAATAGGGCTTACACTTAAACCACAAAACGCTAGGTCTTTGGACCAAGAGAAAAGAGCCAGAAGGCAAAGTAGGCAGTGTACGCCTCCAACACAGTCGCGTTTGTAGGAATCTAGACTCTCTGTGCACGTCTACGAGGCTGTTTGCTCGCTGGGTTCCTACAGGGAACACAGAAGACTGACCCCTGACCTGATTCCTACCCTGTGTACCATCAGCAAATTCACCTCAGAGAACACCAGGACTTTTAAAAATCATTTCTGTGAATATTTTCTCATGTTTTTCTATCCGACAGGTATTTGACATACTAAATCGGAAACCCTATGAGCCTGTGTTCACATCTGATGATATACTACCACAACGTCAGGTCTCGCAGGACAGATTCTCTCAGCCAGTGTTGCCCCATGCTGTGGTTTACAGGAGGAGAGGAGACGCCAGCCTGGGCGAGGGTGTACTGCAAACCGTCTAGATCTTATCTCAGAAAATCAGATCCCTGGAGGTGTGGCCCTGAGCTGCTAGAAGCACCTACTGCTCCTGCTGAGCAGGGCCTCTGGACTTGGCAGAAGCTTGGTGGCCTCCATCACAAGTTGGACAATGACCTGTCCTCTCAGATTGATTGTCCCTGGAAGGTTAAGCAGTCATGTTTCTTCCTTAGGGGACATGAAGCAAGCTGACAGAAGACACGAGGCTACAACTCTGCAAACTGCTGGAAAATTCCTGATCCAGACAAAACTGGGCCACTCTGGCACAGAAGTTGGGTCTGGGGATATTGAACAATGCCTTCCGGCTGAGTCCTGCTCCTTCTAAAACTCTCATGCACAACTATGAGCTAACGCGCCGCCGTACCATTTAGAGTTGTCTGTGTAACTATTGGTAGTTGACCGTGTCAGCTCCACTGAGCAGCACAGCCTACCCCCTTACATAGTAACTTTATGGAAGGAAACCAGTCATTGCCTGGAAGGCAAAGGGAGCCAGGCCAGGATGGTGCCTTTTTCTTGACAAGACTGGTTACCCGTCTCTCGGCATTCCCTGTTTTCAAATTCTCAGAGCCTTCCTGTGAAAATACTACTGCCCACAGGATGGGGACCCCTCCAAGCTGTGATCGGTGTGTGCATCCCTGTTTGCAAAGAGGGAGCCCCCCAGGGCCATGGCTTCATTGTTCTGTCGGGTGACTCCTATTAGAGCAATTCAACTAAAAAAATAGACAAACATGGGCGAGCTACTCCGAATGAGGCTGTCATTGCTAGCTGCTGTCTTCCCTGGATTTCTGTGCGTAGACATCACCGTAGGCAGTCTCCTCTCTCCTGTCTCCATGAACTCACAGGCTTCTTTCCCTTCCTTCCCCTCTTTTTTCTTATCTCTCTCCCCNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNCTACACAGAGGCCATTGAAGTGATCCAGGCAGCCTTCCGCACCCCGGCAACCACAGCCTCCAGCCCCGTGACCACTGCTCAGGTCCACTGTCTCCCTCTCTCCTCTTCCTCCACGAGGCAGCACATAGGTAAAGAGGCTGAGAGAGTTCCTTTCCTCGCTGGCAAGGTCTTTGTGCTCTGGGACGTGGCACTACACTCCCTTTCCCTAGTCTTTTTCCTGACATGTGTTCCTCTGTCGCATGCCACCCGCTCCCTCCCCACAGTGCTCCTCTCCGCACACAGGAACAGGCAGTTCCCACAGACACTCACATTGGCATATAGGTCACTTAGAATCCCAGTAGACACTGGACATGGCGGGGACCGTTAAAGAAACACTACTTCTCATATTTGTTAAATTTGGAGAAAGATTCTAAGAAACCTGCACAGCCCTGGCCCACAGGACAAGAAGTAGGACCCAGGAAAAATGCATACTGTATCACCCTTCCTTTCATGCCACCACCCTTCAGGTCCCCCACCTCCTCCCTCCCTCGGCACTCCCCGTCCTTCAGCTCCCACCCTGCTCATGGTCCTGCCTTTGTCTTCCCACACTAACATCCACCTGTCACCCCCAACACATGCATTTGTACGAATGGATCTCCGTACAGGCTTCAATTATGTCATTGTTCCCGGCCCGTGCTTTCTCTAACCTCTGCACCCTTTCTTCTTGTTCATTTTCTACCCTAGCCACAAACTCCACTGAGACCAGGAACAACTAGCATTCTCCCATCTTTGTATTATGCCAGCACCCCGGTGGCAGGCCTTCCATCTGCGCTCAGTAGGTTATGTCTGCCTTCCACCTGCGGCAGTCCTCCCCTGGGACCCTCCCTGTCACCTTCAGCAGGTCCTGGACACCTGATTCTTGCCTCTTTGTCCTGTACTGTCCTTCCTTCCCCACCTGCTGTGGAGAACCTCTTGCTAGGATGTAACTTCTCATCTTTAAACACTGCCCCGCCTGGCCACAGGCTGCTTAGCCCCGCTTTGATTAATCTTACATCTCAATGAATGGCTTTCTCCATTGATAGCGCTTTGGTTAGCTCATGTTTTCACGTTTGTATGATACATCCTGTTATTTTTGTTCGCATTTCTCATATGGGGGAATCTACAGGTAAACACAGCCTCCAAGTTCAGTAGAAAAATGTCATCATTAAGAGTATTATATCCAATAAACAGTAAACAGATTTTTTAAAAGAGAAAGAAATTTAGAGAAAAACGAGACATCACTTCCTTGTTACACCCTTTAGTTGAGTTCAAACTTCTCAGAACAATATGATAACTGCTGGTCAGCTCACCACCTCTGTCTGCCATCTGCTTCTGTCCCCTCCTCTCCTANNNNNNNNNNNNNNNNNNNNTCCCATTTTCACATGTGTTCCCTACCCTTTCCATCCCTTTAAAGCCTGTTTTCCGCCCCCTGGAGGCCTTTGCTAGTTTTCTGGCCTCTGCTCACGCTCACTTCCACATGAATATACATACGTGACTGTTGGAAGCTAGGATCCACACGTGAGAGAGAACGAATGGTATTTATGTCTCTGGGCTGCCTTGATTAGTATTCTCCATTAACCTCCAACTTTCATCTCTCTTTACGGCCGAAATAACTTTTATCATCTTCACACAACTCTTGGCTCTTGCACAAAACTCATACTGGCCATGACTGTCAAGTATAGCCACGCTGTAACAAAAATCTAAGAGTGGCAATCAATACTTTCTGCCATTCACGTCCTCATGCTTAACCCTGAAAGGGCATCTCTTCTTGGCAGATGCCAAGTTCCGCCCATCCTCACTGCTTGCCTGAACTCCAACAGTGGCTCCTAGTCAGCCTCTTTGACTCTTTGCTTGCCCCTCCATCAGTTCTCTGCACCACAGTGATGTGACATGATAGGGCTCCAGTCACAATTAAAAACTAAATACTTAGCAGCTAGGAACACGCCAAGTGTCCCCTCCTCTACCTTTGGGAAAGCCAGGTAGGCTGACAAATATGTACAACCCGATACCCCACTCATAGAGGAAAGGACACCGAGAGAGGTGGATCCACGGGACTCACTCGCCAGTCTCTAAAAACAAGATGGAGAAGGAACAAGGAAGTCACACAATGTTGACCTCCCCACACCCCACACCTGCACATGAGCACACATCCCACAAACACAAAGCAAATACTTAAATACTGTATTAAATTTCCATCATTCTGACCAACTTAGGAGAGATTTGGTTGGGCACACAGTTTTTATAGGTCCCATGGTCCACTCCCTTCGGGGTATAGCAAAACCCTTCATCACGGAGGAAGCACATGGTAGAGGAATCCTACTCACTTCAAGGTGTTTGGAAGTACACAGAGATGGGGAGGAGCCCCAGTACAGATCTCTTTCAAAGCCACGCCCTCCATGACCTAACTTCCTTCTGTGAGGCCCCATAGTCAAAGAGTTCTATCACCTCCAGATAATGTCACAGGCTAGAAACCAAGCCTTTACTTAGCACACAGCCTTTGTGGGACATTTTAAGATCCGAACCATAATACACAGTAAGCCTTTCAAATGCTGCCCAGTCCCTGTTACACAACAGACAGTTGACTGGATCAGGTAACACCAGGACACCGCTCTGGCATGGTCATTGAGTCTCAGTGTTCTGACGTTAAGATTCAATGATGAGAGTCAAACATTTGCTTAGTAAGTGTTATCCTTCTGTTTCTTTAGTCACTCTGTACAGAAATAATCTGCTCTGGTTCCCAGGAATGCTTTTCAGCTGATAGAATTTAACTTAACCTTTTGGTATAGACACATTTAAAAAAAAAAAAAAAAAGCCTCATTTTCTTCCACCAAAAGAAAATTTTCTAGGCAATGTGTATTCTTTAAAACCTCATACAGCTCAGAGAAACGTGCCATTTTTAGTTCCTCCTTCTGTTATGACTTTATTTTGCCTTGTATTCAGCACTTTGCCCAGCCGTTAAAAAAAAAAAAAAAAAAAAAAAACACAAAAGCTAAATCATAGACCAGTTAGAAAAATATCCCTCACTTTACAAAGGAAAAACATGTTTATCCTGAACCAAGAGAATTCACAACAGATTCTGTTCAACAGAAAGACTGATCTACCCTCTAGCACTCTCTAATGTCATTTGATACCCTGCCATTCACACAGCCAAGCAGCACCGCTTGGCATGATGGGGAGGTGGGATGCCGTGCTCCGCAGGAGCTACCAACCACAACCCTCCATACCATAGTCCACACGGAGCCTCGCAGGGAGCCCACTCCTGTGGATCGTGCTCTACGGCACTCTCACAAACCTCTCTGGGTTTATGTCAGAAGGAATTCAGGGCACCAACCCAAACACTTTGAATCTGAAACTCCTGAGCACCCCGGCTTCCTGCCTCATGGGCTCATCCTCCGCTAGCTTTCTTTTCCTTTTTTTGTTTTGTTTTTTTTTTTTTTTTTTTCCAGACAGGGTTTCTCTACATAGCCTGAGCTGTCCTGGAGCTCACTTTGTAGACCAGGCTGGCCTCCAACTCAGAAATCCGCCTGCCTCTGCCTCCCGAGTGCTGCCATTATAGGCGTCCCCCACCATGCCCGTCTTCCGCTAGCTTTCTTACACAGCCCTGGACTCCCTCTCAGGGAGTGGTGCTGTCTACAGAGGATAGGCCCTCCTCCCGATCAGTTAACTGTCAGGACACGCCCACAGACCAGTCTCATCTGGCTGGCCCTCCCTCATCTCAACACTCCCTCCTCAAGTGATTCTAGACGTGTGAAGTTGACAGTTGAACAAGTCACAGCCACAGCACGCAGAACAGCCCTTCCCATGGCCTAACTCAGCCCCTCATCAGTCTGTGCTTTCTCCGCAGATGAACTCCGGGATAGTGACAGCGTCTGTGACAGTGCTGTGGACACATCCTTCCGCAAACTCAGCTTTACAGAGTCTCTTACTGGAGACAGCCCACTGCTATCTCTGAACAAAATGCCCCACGCTTATGGGCAGGAAGGACCTATTGAAGGCAAAATTTAGCCTCCTGGCCGTTCCCCCACACTGTGTAAACCAAAGCCCTGACAGTCCATTGCATCGTCCCAAAGGAGGAAGGCAAAGCGAATCCAAAGGTGCTGGAGAATCCCCCGCCTGCAGGGTCACTCGATTTCATTCAAGGCCTTCCGAATTTGGCGTCCTTTCTTGGTTCTGAAATGAAATGTAGTTGCCACGCACAGACGGTGTCTAGCAATCATGCCGCTCGCTCGCTCAGCTGCACTCTATGGCTCAGGTGCAGTGTCTTGAACTTTCTCTGCTGCTACTGGATCACATTTGCTTTGTGTTGTTACTGCTGTCCCTCCGCTGGGTTCCTGCTGTCATTAAAAGGTGTCGCTGTCCCCACCCCGTGTCCTTTCTAGCCATCTACTGTAAGTTGTGCATTCAAATTAAGATTAAGGAAAAACATATTTTTAAAATGAGTACCTTCATGCGCAATAAAAAAAGACATTTCTTTTTTTAATGTGGTTTATCTGTGATTTAAAAATAAAAAACACATGAACTTACAATATTTAAACATGCTACAATTCAGTGCTGAAAATAGTATTTTCCCCGTTTTATGCATTTTACTATTGTAAATATGTTTTCTAAATCAATACTTTAAAAGAAGAAATGTTGAAATTTATAAATGCTATTTACTTTTTTATTTTACTTTTATAATAAAAGTACAAGCACATTGTTGACCTAATCTTGTCTGATCTCTGCAAATGCTTTCTCAGAGGAGTCCCTGTGACTGTGGGAACAGCCCCACAGCCCGTTTGTCACATCCACATTCTCCTTTAGACACATTTCTTTGAAGCTAGAAATGTTCAAACTGTGGAAATAAAAGTGTTCTAACCCAAGACTGAGGTTCTGACCCAGGCAACATCATCTGGACGCCTAGCATCAACATTCCAATCTCTACACCGTTCCTCTCCAGCGCATGCTGTCTGTGTCTATCAAGGATAACAGACCCCAGCTTCAGCACTTCATCTTCTGGATACCATGTGGCCGTTGCGTTCATAGCTAACTACACAAAACCTGTACAAGATGTGGTCCTTCATCATGTATACAAGAGGGACTGATCAATACACACACACACACACACACACACACAGACACCACAGCAACTGGCTGTTAATAGTTGCTAGGGGAATGGGAGTCCTTTCTTCAAATGGTATAGCACATACTCCACTAACTATTCCCTCCCCATGTTCATGCAGGCAGCCCTAAATTAACTCACTCATACACACAAGCACAGAAGCAGGAAAGTAGGAGGCGGAAACGAGAACCCAGCGGGGTTTGTGGATATGATCTCAGTACATCCTATACATGTTTAAGATCATGAGAAAATATACATTTTAATTAAAAACTAAATTCCAACATATGTAAAAGATTTTCCAGTATCCAGTTTAGTAAGTCTGCATGGCTGAAAAGTAGAAGAGGGAAGATTAATCGCTTGAAGAGGTCTTAGTTTGGACTCTGGTGTGTGACCAAAGGTCATTTAGTGTGTAGTGTGATCAAAAAATCCAAAACCTTCTGGTGAAGTGGCTTGGCAGTTAAGAGCACTGATCTTCCAGAGGACCAGTCAGTAGGTTTAATTCCTAGAACCCCTCACAGCTCACAACCACCTGTAACTTCGGTCCCAGGGAATATGATGCCCTCTTCAGGCTTCTGTGGGCACCAGGCATATAAATGGTGCACAGATATACATGCAGGCAAAACATCCATACACACAGAAAGAAAAAACCAAAAACCTAAGGCCTTGTCATGCCACACAAGTGATCTACTACTCATCCCACGGAAGGGCCTGGAAACCCACCAGCTATTACCTTTGGGAACTGCCTTCACTACAAAGAGCTCTCACCCCCATTTCCATGGTAGTCATATGAATGCCTTTCCCATTGCTGGGACCTTCAGATCCTGGGAGACAGGCTAAAGTGATCTGGGCTATCTCCCTCACACAGCTCAAGGTACCCCAAATAGACATCTTGTATGTCAGTGTCCATATGACAAAATATTCCAAACTTACAATGAAGAAAATGGAGGTCCAGAGACCGCAACTCAGTTGTGGCTAAGGTGCATCTGTGTTTATATCCAGATACTTAGCGCCTAGGCTTGTGAGTTAGAGAATGATTTTATTGGGACAAAAAAGATGATAATGACTGAATCTATTAGTAGGGATTTGGTATAAGATTAAGTAAAAATATCATTAATGAAGAAATGATTAATTATTTAATATATAATACAAGCTACTTAATAATACTTAAATTATTTAATAAATATTCTAAGTGCCTAATCATCAATTAATCGGAATCCCTTTCTACCAAAAATTCCATATGTATGAAAATTTAAACCATACGAATTTTAGACATACCACCAATCTTAGACAAACACCCTTGACATCGAGAAGGCCCTTATCGAGACTTCATTCTGTGATCTAAAAGCAGAGCAGATTCTACCTCTTAGAATGCATCACAATGAAAAACAGAACTGGTTAACAGCAAATTCTGTTTTCCATTACAGTACCCTCTCTCCACCCTAACACACCCTTATTCTGCGTTGGAAACTTTAAGACAAAACTGTCTTGCTTTGGTGTTTCCTAATACTTCCTGGGACACCCATGCCACCATGCCCCAGCCAGCACTTTCTATGGCTGTTACCTCTCCGTCTTAAAACATGGTGCTAAAGCCCTTCCCACAGAGAGACACCATTCTTTCCTCGCTTTAGGCTCCTGAGTCCAGGCCACCTGTGGCAAGGCAGGAACGATGCTGAGTGACTTCCGAAACTAGGTCCGAATTTCTGCCAACCTTCCCGAAACTACCTTCTCCTGGAACTCAGTCACCCTGTTCAGAGGGTGCCAAGCAGCCATGAAGAGAAGGCCAGTACAGGTGTTCAGCCAACAGCCTTAACCGAGGTCCTAGCCAAAGCTTGCCAAGCCGACGGCTGCCAGGTGACCCTGCCTAGCCTTTAGGCTGTCTCAGCAGATGCTCACCACAATAAACATGGGCTGTTTTGCTGTTCTCAAAGGACAGATTTCAAAGCAAATTAAATACTAGTGGGGGTTTTAAGCCCTGGGTGTAGAGTGGACACCACCATTCTCCAGGCATTTGAAAAGACAGCTTGCCTACCATAAGTTCAGCAGAAAACAAATACTGACTGGAGACACGC MOUSE SEQUENCE - mRNA (SEQ ID NO:26)AGCGGCCGCCGCGGGCGCGCTCTAGCAGCGCAGGCCGCACCTCAGGGCCCCGCGCGCCCGGCCCGCCCCGCGCTTCTCCGCCCGCGCCGCAGCCATCGCCCGCCGCTGAGCCGCCCGCCCGCCCGCCCGCGCCCCGACCCGGCTCGGCTCCCGCCGCTCCGCGCCGCTCCGCAGCGGAGCCCGCAGGCGAGGAGAGGCCCCCCGCATCTCCAGGGTACCCTCAGAGGCCAGAAGAGGGTGTCAGAGCCCTTGTAACTGGAGTTTGACGGTCGTGAGCTGCGCATCTTCACCATGGCAGACGATGATCCCTACGGAACTCCCCAAATGTTTCATTTGAACACTGCTTTGACTCACTCAATATTTAATGCACAATTATATTCACCAGAAATACCACTGTCAACAGATGGCCCATACCTTCAAATATTAGACCAACCAAAACAGAGGGGATTTCGATTCCGCTATGTGTGTGAACGCCCATCACACGCACGCCTTCCGGGAGCCTCTAGTGAGAAGAACAAGAAATCCTACCCACAGGTCAAAATTTGCAACTATGTGGGGCCTGCAAAGGTTATCGTTCAGTTGGTCACAAAATGSAAAAACATCCACCTGCACGCCCACAGCCTGGTGGGCAAGCACTGTGACGACGGGGTATGCACCGTAACAGCAGGACCCAAGGACATGGTGGTTGGCTTTGCAAACCTCGGAATACTTCATGTGACTAAGAAAAAGGTATTTGAAACACTGGAAGCACGGATGACAGAGCCGTGTATTAGGGGCTATAATCCTCGACTTCTGGTGCATTCTCACCTTGCCTATCTACAAGCAGAAGGCGGAGGAGACCGGCAACTCACAGACAGAGACAACCAGATCATCCCCCAGCCAGCCGTGCAGCAGACCAAGGAGATGGACCTGAGCGTGGTGCGCCTCATGTTCACAGCCTTCCTCCCTGACAGCACTCGCAGCTTCACTCCGAGACTGGAGCCTGTGGTGTCAGACGCCATCTATGATAGCAAAGCCCCGAATGCATCCAACCTGAAAATCGTGAGAATGGACAGAACAGCAGGATGTGTGACGGGAGGGGAGGAGATTTACCTTCTCTGTGACAAGGTTCAAAGAGATGACATCCAGATTCGGTTTTATGAAGAGGAAGAAAATGGCSGAGTTTGGGAAGGATTTCGGGACTTTTCCCCCACGGATGTTCATAGACAGTTTGCCATTGTCTTCACGCCAAAAGTATAAAGGATAATCAACATTACAAAGCCAGCTTCCGTGTTTGTTCACCTTCGGAGGAAATCAGACCTGGAAACTAGTGAACCGAAACCCTTTCTCTACTACCCTGAAATCAAAGACAAACAGGAAGTGCAAAGGAAACGCCAGAAGCTTATGCCCAACTTCTCGCACAGCTTCCCCGGCCGCAGTGGAGCGAGCCGGTGGTCCAGCCATGTTCGGTAGTCGCGCTGGCGGAGGGAGTACCGGAAGCCCTGGCCCAGGGTATGCCTACTCGAAAACTACGCATTTCCTCCCTACGGTGGGATTACATTCCATCCCGGAGTCACGATCCAACCCAGGGGTCACCCATGGCACCATAACACCAAAAAATTTAAAAATCCCCCTAAAGATTGTCCCAAGACTGATGACGAGGAGAGTCTGACTCTCCCTGAGAAAGGAACTGAACGTCAAGCGCCCACCCTGCCCATGGCCTGCACCAAGACCGAAACCCATCGCCTTCGCATCCACCATCCAAGACAACCAGCAGGACATGGGATTTCAGGATACCTCTTTCTCGAGAAGGCTCTGCAGCTCGCCAGGCGACACGCCAACGCCCTTTTCGACTACGCACTGACGGGGGATGTGAAGATGTTCCTGGCGGTGCAACGCCATCTCACCGCCGTGCAGGATGAGAAATCCCCACAGTCTCTTACACTTAGCCATCATCCACCTCCACGCTCAGCTCAAGAGGATCTCCTGGAAGTCACATCTCCTTTGATCTCTGATGACATCATCAACATGAGAAATCACCTCTATCAGACACCTCTGCACTTCCCCGTGATCACCAAGCAGGAAGATGTATAGACAAATTTGCTGAGGGTTGGGGCTGACCTGACCCTTCTGCACCGCTGGGGCAACTCTCTCCTGCACCTACCTGCCAAAGAAGGACACGACAGAATCCTCAGCATCCTGCTCAAGAGCAGAAAACCACCGCCCCTTATCGACCACCCCAATGGGGAAGCTCTAAATCCCATCCACATAGCTGTGATGAGCAATAGCCTGCCATGTCTGCTGCTCCTGGTGGCTGCCCGCCCAGAAGTCAATGCTCACGAGCAGAAGTCTGGGCGCACGCCGCTGCACCTCGCCGTCGACTACCACAACATCTCCTTGCCTGGCTGCCTGCTTCTGGACGGTCATGCCCACGTGCACACTACCACCTATGATGGGACTACACCTCTGCATATAGCGGCCGCAAGAGGGTCCACCAGACTCCCAGCTCTTCTCAAGCAGCAGGAGCACACCCCCTCCTGCACAACTTTGACCCTCTCTATGACCTGGACGACTCTTGGCAGAAGGCTGGAGAAAAATCACGCAGTGGTCCCAGGTACCACACCCCTGGACATGGCTGCCAACTGCCACGTATTTCACATACTAAATCCCAAACCGTATCAGCCTGTGTTCACATCTGATCATATACTACCACAAGGGGACATGAAGCAGCTGACAGAAGACACGAGGCTACAACTCTGCAATCTGCTCGAAATTCCTGATCCAGACAAAAACTGGGCCACTCTCGCACACAAGTTGGGTCTGGGGATATTGAACAATGCCTTCCGGCTGAGTCCTGCTCCTTCTAAAACTCTCATGGACAACTATGAGCTCTCTGGGGGTACCATCAGAGCTGATGGAGGCCCTGCAACAGATGSCAACTACACAGAGCCCATTGAAGTGATCCAGGCAGCCTTCCCCACCCCCGCAACCACAGCCTCCAGCCCCGTGACCACTGCTCAGGTCCACTGTCTGCCTCTCTCGTCTTCCTCCACGAGGCAGCACATAGATGAACTCCGGGATAGTGACAGCGTCTGTGACACTCGTGTCGACACATCCTTCCGCTAACTCAGCTTTACAGAGTCTCTTACTGGAGACAGCCCACTGCTATCTCTGAACAAAATGCCCCACGGTTATGGGCAGGAAGGACCTATTCAAGGCAAAATTTAGCCTGCTGGCCGTTCCCCCACACTGTGTAAACCAAACCCCTGACAGTCCATTCCATCGTCCCAAAGGAGGAAGGCAAAGCGAATCCAAAGGTGCTGGAGAATCGCCGGCCTGCAGGGTCACTCGATTTCATTCAAGGCCTTCCGAATTTGGCGTCCTTCTTGGTTCTGAAATGAAATGTAGTTGCCACGCACAGACGGTGTCTAGCAATCATGGCGCTCGCTCGCTCAGCTGCACTCTATGGCTCAGGTGCAGTGTCTTGAGCTTTCTCTGCTGCTACTGGATCACATTTGCTTTGTGTTGTTACTGCTGTCCCTCCGCTCGGTTCCTGCTGTCATTAAAAGGTGTCGCTGTCCCCACCCGGTGTCCTTTCTAGCCATCTACTGTAAGTTGTGCATTCAAATTAAGATTAAGGAAAAACATATTTTTAAATGAGTACCTTGATGCGCAATAAAAAAAAAGACATTTCTTTTTTTAATGTGGTTTATCTGTGATTTAAAAATAAAAAACACATGAACTTATCAATATTTAAAACATGCTACAATCAGTGNTGAAAATAGTATTTTCCCCGTTTTATGCATTTTACATTTGTAAATATGTTTTCTAATCAATACTTTAAAAGAAGAATGTTGAATTTATAAAATGCTATTTACTTTTTTATTTATAATAAAGTACAGCACATGTGACT MOUSESEQUENCE - CODING (SEQ ID NO: 27)ATGGCAGACGATGATCCCTACGGAACTGGGCAAATGTTTCATTTGAACACTGCTTTGACTCACTCAATATTTAATGCAGAATTATATTCACCAGAAATACCACTGTCAACAGATGGCCCATACCTTCAAATATTAGAGCAACCAAAACAGAGGGGATTTCGATTCCGCTATGTGTGTGAAGGCCCATCACACGGAGGGCTTCCGGGAGCCTCTAGTGAGAAGAACAAGAAATCCTACCCACAGGTCAAAATTTGCAACTATGTGGGGCCTGCAAAGGTTATCGTTCAGTTGGTCACAAATGGAAAAAACATCCACCTGCACGCCCACAGCCTGGTGGGCAAGCACTGTGAGGACGGGGTATGCACCGTAACAGCACGACCCAAGGACATGGTGGTTGGCTTTGCAAACCTGGGAATACTTCATGTGACTAAGAAAAAGGTATTTGAAACACTGGAAGCACGGATGACAGAGGCGTGTATTAGGGGCTATAATCCTGGACTTCTCGTGCATTCTGACCTTGCCTATCTACAAGCAGAAGGCGGAGGAGACCGGCAACTCACAGACAGAGAGAAGGAGATCATCCGCCAGGCAGCCGTGCAGCAGACCAAGGAGATGGACCTGAGCGTGGTGCGCCTCATGTTCACAGCCTTCCTCCCTGACAGCACTGGCAGCTTCACTCGGAGACTGGAGCCTGTGGTGTCAGACGCCATCTATGATAGCAAAGCCCCGAATGCATCCAACCTGAAAATCGTGAGAATGGACAGAACAGCAGGATGTGTGACGGGAGGGGAGGAGATTTACCTTCTCTGTGACAAGGTTCAGAAAGATGACATCCAGATTCGGTTTTATGAAGAGGAAGAAAATGGCGGAGTTTGGGAAGGATTTGGGGACTTTTCCCCCACGGATGTTCATAGACAGTTTGCCATTGTCTTCAAAACGCCAAAGTATAAGGATGTCAACATTACAAAGCCAGCTTCCGTGTTTGTTCAGCTTCGGAGGAAATCAGACCTGGAAACTAGTGAACCGAAAACCCTTTCTCTACTACCCTGAATCAAAGACAAAGAGGAAGTGCAAAGGAAACGCCAGAAGCTTATGCCGAACTTCTCGGACAGCTTCGGCGGCGGCAGTGGAGCGGGAGCCGGTGGTGGAGGCATGTTCGGTAGTGGCGGTGGCGGAGGGAGTACCGGAAGCCCTGGCCCAGGGTATGGCTACTCGAACTACGGATTTCCTCCCTACGGTGGGATTACATTCCATCCCGGAGTCACGAAATCCAACGCAGGGGTCACCCATGGCACCATAAACACCAAATTTAAAAATGGCCCTAAAGATTGTGCCAAGAGTGATGACGAGGAGAGTCTGACTCTCCCTGAGAAGGAAACTGAAGGTGAAGGGCCCAGCCTGCCCATGGCCTGCACCAAGACGGAACCCATCGCCTTGGCATCCACCATGGAAGACAAGGAGCAGGACATGGGATTTCAGGATAACCTCTTTCTCGAGAAGGCTCTGCAGCTCGCCAGGCGACACGCCAACGCCCTTTTCGACTACGCAGTGACGGGGGATGTGAAGATGTTGCTGGCCGTGCAACGCCATCTCACCGCCGTGCAGGATGAGAATGGGGACAGTGTCTTACACTTAGCCATCATCCACCTCCACGCTCAGCTCGTGAGGGATCTGCTGGAAGTCACATCTGGTTTGATCTCTGATGACATCATCAACATGAGAAATGACCTGTATCAGACACCTCTGCACTTGGCCGTGATCACCAAGCAGGAAGATGTAGTAGAGGATTTGCTGAGGGTTGGGGCTGACCTGAGCCTTCTGGACCGCTGGGGCAACTCTGTCCTGCACCTAGCTGCCAAAGAAGGACACGACAGAATCCTCAGCATCCTGCTCAAGAGCAGAAAAGCAGCGCCCCTTATCGACCACCCCAATGGGGAAGGTCTAAATGCCATCCACATAGCTGTGATGAGCAATAGCCTGCCATGTCTGCTGCTGCTGGTGGCTGCCGGGGCAGAAGTCAATGCTCAGGAGCAGAAGTCTGGGCGCACGCCGCTGCACCTGGCCGTGGAGTACGACAACATCTCCTTGGCTGGCTGCCTGCTTCTGGAGGGTGATGCCCACGTGGACAGTACCACCTATGATGGGACTACACCTCTGCATATAGCGGCCGGAAGAGGGTCCACCAGACTGGCAGCTCTTCTCAAAGCAGCAGGAGCAGACCCCCTGGTGGAGAACTTTGAGCCTCTCTATGACCTGGACGACTCTTGGGAGAAGGCTGGAGAAGATGAGGGAGTGGTGCCAGGTACCACACCCCTGGACATGGCTGCCAACTGGCAGGTATTTGACATACTAAATGGGAAACCGTATGAGCCTGTGTTCACATCTGATGATATACTACCACAAGGGGACATCAAGCAGCTGACAGAAGACACGAGGCTACAACTCTGCAAAACTGCTGGAAATTCCTGATCCAGACAAAACTGGGCCACTCTCGCACAGAAGTTGGGTCTGGGGATATTGAACAATGCCTTCCCGCTCAGTCCTGCTCCTTCTAAAACTCTCATGGACAACTATGAGGTCTCTGGGGGTACCATCAAAGAGCTGATGGAGGCCCTGCAACAGATGGGCTACACAGAGGCCATTGAAGTGATCCAGGCAGCCTTCCGCACCCCGGCAACCACAGCCTCCAGCCCCGTGACCACTGCTCAGGTCCACTGTCTGCCTCTCTCGTCTTCCTCCACGAGGCAGCACATAGATGAACTCCGGGATAGTGACAGCGTCTGTGACAGTGGTGTGGAGACATCCTTCCGCAAACTCAGCTTTACAGAGTCTCTTACTGGAGACAGCCCACTGCTATCTCTGAACAAAATGCCCCACGGTTATGGGCAGGAAGGACCTATTGAAGGCAAAATTTAGHUMAN SEQUENCE - GENOMIC (SEQ ID NO: 28)TTGACAAGCTGGTTCTAATGAATTCAGATGCAGGACCTAGAATAGCCTAAAACTAAAAACCTTGAAAAAGTGAACAGAAGTTGGAGGACTAACACTTCCTGATTTCAAGACTTATTGTAAAGCTATAAGTAATCAAAAAGGTGTGGTATTATCATATAGATAGAGAAAAAGATCAATGGAACAAAATAGAGTCCAGACATACAGATACAACTGATTTTTAACAATTTGCAAAGGCAATTTAGTGAAGAAAGGATAGTTTTTTTTTTCAACAAATGCTGCAGAATCAGTTGGAAATCAATAATCTAAAAAGAAAAAACTTCAATCCATATCTTGTACCACTATATGCAAAACTTAACTCAAAATGTATCATAGACCTGAATTTAAGTCCTCAAACTACAAAAGTTCTAGAAGAAAATAGAGGAGAAAATCTTAGTGAGTTTGAGTCAGGCAAAGAGTATGTGGATACAACACTGAAACCACAATGCAGTAAAAAACTGACAAATTATACTTCATCAAATTTAAAATCTTCTCTGCAAAAGAGGATGAAAAGACAAGTCACAGGCTAAAAATATGTATTTGCAAATCATATATCTGGTTAAAATACTTTTATCCAGAATATAAAATGAACTCTCAAAATTCAATAATAAGAAAAAAAATACACCAAAAGTAAACAAAACATTTGAACATGCATTTCACCAAATGGCAAATAAGCACATAAACAGATGCCCATCATCATTAGTCATTAGGGTAAAGCAAATAAAAGCACAATGAGATACCACTAAACATATCAATTGAGACGATTAAAATAAAAAAGACTGACCATACCAAGGATTGCAAAATATATGAAGGAGCTAGAACTCTCATTTCCTGTAGTGGGAATATAAATAATATACTCTTTGGGAGAACAGTCTGCAGTTTCTTAAAAAGTTACATGTATGCTAACTATACGCTCTAGCCATTTCACTTGTAGGTATTTCCCATGACAAAAGAAACTATATGTCTATATAAACAGTTAAATAGTTACACACAAATCTTTTAGTGGTTTTATTAATATATCCCAAAACTGGAAACAACCTAAATGTCTATGAACAGGAAAATGGATAAATAAATTGTGACTATCTATACAATGGAATGCTACTCAACAATAAAAAGGAATTAACTACTCATACAACAACGTCGATGAATTTTAAGATAATCATGCTCAATGAAAGAAGTCAGATAAAAAATAGTACCTACTGTATGATTCCATTTATATGAAACTCTAGAAAATGCAAACTAATCTATGACAGAAAGCAAATCAGTGGTTGCTTAGGAATGTGGAGGAGTGAGGAATGGAAATCACCAACTGCAGACGGCCATGAGAAAACTTTTCAGCTGATGCACATCCTCACTCTCTTTATTATGCTCATGGTCTCATGGGTATATATATATATCAAAAACAACTCTCTCTCTCTCTCTCTCTCCAATCCCCCAACCCCATCTCTTACAACAACAATCTATCTCCCTAGTATATCTGGAAGCCATCTTTTGACCAAGAGAAAAGCCAGCATGAGGAAACTGTTAACACAGGGACAGAAGAAAAGAAAATGTCTCTGAAGGGAAGAGAGCCAGAATTCTCATTACATTAAACCTAAAGATTTTCAACCATGTGACCTGATGAAATTCCATAAATGCTTACTCATTTTGAGTCATAATTTTACATCTTTTCACCTTAGGTGAAAAGCATCCTAACCAAGATAAGTATATGCTCAGCATTATATTGATAATTTATAATACGCCATTGGAAAAAAACTCTCTTCCTGGCATTTAATTATATTACTTATTTCAAAGAAAATGCAGTAAAAAACTGATCTGTATATCTACTGATATGTCTATCAGTAAAACAGATAAGTATATCTATGTATACCTACTATGCATAAGCCTTACAGGTCCTACATACACGTGATATCTCTTGTTTATACTCTTTGTCTTCCCTTCTTCCTTTTTTTGATAACAGTGCCCCAATTTACGCTTAGCTAACCATAATCTAGCATTACTAATTCATGTCTTCCAGATGACATAGACCCTCCTTGTCACTAAAAGTAGACATGTGACTCACAGCATTCTAACAAGATAGTAATGGAACACAGGTCCCCAAATTTACCCTCCCAATCTCTTCTCAATTACTTTCCCCAACAAGAAAAAATGCTACTGCAGGTAAGCAGGGGCATCTAAACCAGGGTCACTTGAGGTCACAGGCTCCAGGGTCTCTAAAAGGAAATGAGATACTCTCACTCTTCTCTGTTTTAGCTACTCTCGAGGGCCTTGTTATAGAAGACTTAAAACAAAGGTCTCAATTTTATGGCTTCCACTGAAAGTTAGCCTGAGGAAACCTATGAATGCCTTCACCAAACCATTACATGGGCTTATTTGTGTGTGTTCTTGGGAAGGTCAGACTAATCTGGGTAGTGACAGGTCATATGGAGGAACGCTGCACTCATGGAAGAGTTGCTTGTAGCCCCTGAGGTTAGGCAAGCATTCTCCCTTGCACCCAGGGAGCTCTGGGAGAAGAAAGACTTTTTTTAAACCTTCAGCTGGCTGTGGACAGATTGCCAGTTGGTTTACTGCCAGCCCACAAAAGCAGAAACCTTTCCCCTGGCAGGTTTGCCACTGCATAAAAGACCCTAACTACTTGTCCTGTAATTATAGGTCAGTGTATACAGAGCCTGAGGTCTGAACAGGAAATGGAAAATAATAACTTGCCCTAGTACTACTAGCAAGCCAGAGAGGAAAACTAAGATAAACACTTCAAACAGGTCTTTTGTTGAAATAGAACTGTTAGAAGAGCCAGGTGAAAAACTTTTCTAAAAGTAATAAATTCACTCAAGAAGATATAATTAAAGATTAGGAGTTAAAATATATCATAGATGCTAGAATGATAAAATATACATATTTTAAAATAGGTAATGACTCCATCTGTTTCTGACAGTATACCCTTCCTGGTTGAAAATAACTAAAATGATAACTAATGCATAAAAAACTGAATGCTACATAACATATTTTTAAAAATTAATACTGCTTAGCCAGCATGAAATTCAGGAATCTAATATTTCCAAAACTGAAAAAACTGGAGGGAATAGCTGAGAAATTGACTTAGTCTGTTTTGTGTTGCTATCACAGAAAACCACAGACTGGGTAATTTATAATGAAAAGAAATTTGTATCTCACAGTTCTGGAGGCTGGGAAGTCCAATATCAAGGTGCCAGCATCTTGTGAAAGCTTTCTTGCTACATCATCCCATAGTGAAAGCAAGAAGAGCAAAAGAGCAGACACTCAAGAGAGAAAGTAACCTACTCCTACAATAATGCCATTCATCCATTTATGdGGGTAGAGACCTCATGACCCAATCAGCTCTCAAACGTCTCACCTCTCAACACTGTTGAATGGGGAGTTAAGTCCCAACACAGGAACTTTGGGGGACATGTTCAAACGATAACACTGCCTATCTAGTCCTTGTCACTGGACAGAAAAACAACAAATTCTCACCTGTGAATTCATAACCACTTACACTATATGTGATGATCAAAAGCACACAAGTAAAAAATTTTATTTAAGGTTTTTCCAAGTTAATAGTATACCAGATAACAGGCAAAAAGAAAGCACAATATTCCTTACTCAATTTTAACCTAAGCTTCAAATAATTTCCAGAGATTCTTTCAAGAAACGTAAGCAATTTATTATTTATAATTCAGTTGACATATTAAACAGCATATGAAATATAGCTGAAAAGAGAATTGATAAACTAGAAGGCAAATATAAAGAAATTATCCAGAATGAAATCCAAAGAGATAAGAGATATTAAAAGACACAGAGATTAGATTGAGAAGATCTAACATATACCTAATTTAAATTCCAGAAAACAAGTCTAGGGAAAATGAAAGAGAGGAAATGTTACAAAAGATAATGGACTAGGAATGTAACTGTTGAAACATCAAATCTTGAGACCCAGGGAGCCATATAACATGCTTCCAAAATCCAACCTTATTATATTAATATACAAAAACATTAATATTAATATTATATATTAATGTTATTGTTAATATAATCATTATATTATTAAACATATAATTTATACATAACAATATATTATATATAAAAATGTATATGATATATAATATACAATAGTTATAATTTATATTAATTATATATTGACTTCTATATAATATAGAATTATATAACTTATAAATTATATATAGCTTTATATATAAATCAATAATTATATATTGATGTGTACAATTATTATTTTATATTATTATTAATAATTATATAATTGGTATTATATAAATATTAATTTTATATTGCAATAGTTATAAAATAATAAACATATAACATTATTAATATAATAAATATAGTATATTAATATTAATAACTTGTATTTATTACAATATATTAATAAAATGACATAATTTCACATTTCTTTCAGATTTCTGTAAAAGCTTATCAGGAGTTATATATATGCAAAACCATATTTATCTTATTAAAGAGGCATGTATAAGTGTCAGACCATCACTTATGAATAGATTTGACACCCAGATATACAACCTTTCAGAAACAGAAGCAAACCTCCTCCATAAACAAGTTTAAATTGCCACCTGTCTCAATGATGTCCAGTAACTAGCCTTATTTCACTCAGAACAGTTTTGTCGGCTTCATATAGCATGACCAATCACCCTGGTTTACTAGAGCCTGAGGGTTTCCTGCGCAAGGGACTCTCTGTGCTAAAAGCAACATAGTCCTGCATCAACCGGGATGAGTTAAGTCTCTATTTCCATGCCTTCATAGAAATCATTAAAAGATATCTCTCTGTTATGGGCTGAATAATGTCACCCACCCTGAAATTCCTATGTTGAAGTCCTAACCCCCAGTACCTCAGAATGTAACTGGATTTTGACATAGGGTTTTTAAAGACGTATATAAGTTAAAATGAGGACAGTGGGATGGCCCCTAATCTAATATGACTCATGTCCTTATAAGACGAAATGATTTGGACGTGGACACACAGCGACAACCACATGAGGACAGCGAGAAGATGGCGTTTAGTGTATTTCAGCTGATGATTATAGCCTAATCCTCCCCCTCTTCTTGGGGCCTCTCTTCTCTGTACTCTTCCTCCTCATATCTCATATTTCTCTTCTTTAAGCCACCCAGTCTGAGATATTTTGTTTTCGCAGCCCTAAACAAACACATTCTCTACGCTTTATTCTCATTTTTGGTTTAGTGTATTTCAGCTCATGATTATAGCCTAATCCTCCCCCTCTTCTTGGGGCCTCTCTTCTCTGTACTCTTCCTCCTCATATCTCACACAGGCAGATTTCTTCCTGCCTCCTCACCTACATTACGAGCTCCGCACAGTCTCCTTTCTTCTGGCTCCGGCTCCCTCATTAATCTTTCTGTTATTAACGCTATTAACTCGTTAAACTATCTCTCCACCTTTCCAAACTTCCATTAACTCTCGCACTCCATAAGTGTTAGTCAAATAAATGAAGAATCACACTAACTCCTCTTTCCTTCCCTCTCACTCCAAACTCTTGGTGAGATTCTTTTGCACTTATGCCCTCGTTTCCCCATTCTAATCACTCAGACTAGAACACTCAGAGCTATCTATGAGTCTTCCTCTCACTCAAACTGCATATATAATCTATAAACAGGTCCTGTTGCGTATCAGTGCTATTTGAGAGTTAATAAAGTTCCCTTTTCCTCCAAGGACAGCGAGCAGAGTGAACAGAAGAAGACTGCTTTCTCCCCTTGGCTGCACAGCCATGCCCCGAGGCCGGGCTTAGGATTTTATAATTCACAAAGTCAACTGTCTCTTCCCCTCTCCATCCTTTAGGAACTGTCTGCAGTATCTCACACTGTTGAGAGCTCTCATACCCTTTAAACTCTCTCTTCTCTGCCTTTCTGACCTTTCCTCCCACTTTTGATGGCACTGCAGGAGTTTTTAAGCATCTCTCTCTCATACCAACCCCAGAAATAAAGTCATTCCTCGAATTCCTGTACTTACCCCCTTGTCTCCTAACTCTTTGACCACTAATGTTTTAGAAACACTCTCCTGACAACTATCGCATCTTTGCAGTTGTTTCCATTTCCAACGCCATGTCTCTCTGAGCAGCAGCCTTGAGTTTTCAATTCCATATTTATTAGTCATTTCCATATGGACATCTCACTAAATCTGTCATACTAAACATGTCTAAAATATGTATGTTTACATGTTACATGTATGTTTGGTATGTGGCAATGCATTACATTCCCACAGATTTTTTCCCAGTTACACTCTTACTATTCTAATCACTCAGACTAGAACACTCAGAGCTATCTATGAGTCTTCCTCTCACTCAACTGCATATATAATCTATAAAACAGGTCCTGTTGACCTCATCTTCTAAAAATCTCTTACATCCTCCTTTTTATATCATTGGATAATAGTTTAGTCTCGTGGTTAATATCATCCACACTGGAGCCAAATCTGTTAGGTTCAAATCCTCACTCTCCTTCTATTTACTAATTATGAAACCTTAGGAAAATTATTCAACTTTTCATCTGTAAATATGGGGATTATAATGGTGATCCACTTTATATGACTGACAACCAAATAAGTGAATACGTGTATAGCAGGTATTAACCATATGCTTAGCCGACCTATTTCAACCTCCTAACCAACCAGAAGAACTGTAGTTCCCTGCTCTCTTGCATCTAAGTGGGGCCATGGAATGTGGGCAGAAGTGTTGTGTCACCTTTACTCAGAGGCAATTAAAAAGAAGACATACTTTTCCTATGTTCTCATTGCCAATGAACACACTACACAGATCTCAACCTCAGAATTCTCTCCACACTGGTATTTCCAAAATAGCTTCATGAGAAGGGAAATTTGTGTAGTTTCAATGATTTAGTGATGCTATGGTTTGGCTATTTGTCTCCTCTAAACCTCATGTTGAAATGTGACCCCAATTTTGGAGGTGGGGCCTTATGGGAGATCTTTCGGTCATGGAGGTCCATCCCTCACAAATAGATTGATGCTATTCCCTGCAAGCAGGAGAGCATGAGTCACTTCTCACTGCATTAGTTCCTATGAGAGCTGGTTGCTAAAAAGTTTGGCATCTCTCCCCTCTCTCTCGCCATACGATCTCTCTCCACACACCACCCGCCTTTGCCTTCCATTCAGTGCAACCACCCTGACGCCCTCACCAGACGCATATCCTGCTGCCATGCTTCTTGTACACTCTCAAGACTGTGAGCCTAATAAACCTCTTTTCATTATAAGCTACCTAGTCTTGTGTATTCTGCCATAGCAACACAAATGAACTAAGACAAGTGACAAACACAAAATAACTTGTCTTTTAGACAATATTGATGTCTGAAATTCCACATTGAGGCATTTTTTTCCTCTTCGTAGCCTGATAATGGCAAATACCTTCTGACACCTTAGGATGGATGAATTTGTAAGAGATATTCCTGGAAGCAGGTTTGTACAGTGTAGAGAAAATGTTGGGTAACAAAGCAGGAATGGAGGAGGGTTAATCAGCAAGCCAAAAAGCTTTTATAGTTTTGCCTGCTGTGCTGCATGGAATTACATCCCCCCAAAACATATGTTCAAGTCCTAACCACAGGTACCTGTGAACATGAGTTTATTTGGAACTAGGATCTTTGCAAATGTTATCAAGTTAAGATGAGGTAATACTGGATTGGGGTGGGCTCTAAATCCAATGACTGGTGTCTTCATAAAAGAAAGGTGAGGGGAGAGTTGAATATAGCGACACAAAGGAAACACGGGGAGGAGACCATGTGACAATGTAGGCACAGAATGGACTGTTGCAGCCAAGCCAGAATGGCAAGGATTCCTGCACCTACCAGAACCTACGAGGACGCAAAAAATTCTTCCCTAAAAGCCTTCAGAGGGATCATGGCCTTAATGGCACCTTGAGTTCAGAATTTTAGGCTCCAGGACTGTGACAGAATAAATTCCCGTTGTAAGCTGTTCAGTCGGTGGTAAATTTTTACAGCAGCCCCAGGAAAATATGCCTGCTCAACAGGGTACCCTGAATTTTAAGTTCATTTTATGGAATCATTTTGAGTTTGGAGTTTCATTTAATCCTTTTCACTAAAATTAACGCTCTTCATTTTTTACTCCCAAATGTCACACTGGCTCTACTCTTATAACAATTGTATTTATCTATCTTTTGGTAATGGGGCTGCCACCCCTTGCAGAATGAAAAGTAGAGTGTGTATGCTCACACCTCCCTCCCTCCCTCCCTCTCTCCCTCCCTCTCTCTTTCTTTCTTTCTCAGAGTATCAACTCTGTCTCCCCCAGGCTGCAGTGCAGTGGCCCATCTTGGCTCACTGCAACCTCTGCCTCCAGGGTTCAACCGATTCTCCTGCCTCAGCCTCTCGACTACCTGGGATTACAGGCGCCCGCCACCACGCCCGGCTAATTTTTTTGTATTGTTAGTAGAGATGGGGTTTCACCATATTGGTCAGGCTGGTCTCAAACTCCTGACCTCAGGGATCCATCCCGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCGCACCCGGCTCACAGAATTTCTTTAAAAAGTCATTGTGTTCAGCTTTATGGATCCTCTAAATTCCAGCTGCTCAGCCTCCCGGAGCTAAAATGAGATCACTTAAAGTCGACTCTTGGGGCCTCCAAGGTCGCCTCGGAGACTCACCTCATAGGCAATCAATGGATCGCTGGGTTTTTCTGTGTGTGGGTTTTTTTTGTTTATTTTTTTTTTCCACTAAAAACACTCCACCAAGAAGGTTTTTATAACCTACTGCAGGAGGAGGATGGAGAGTGGGCACGAAAGACTAGGATGAACATGCCATAAGCAAATCTAAATGCCACTGCAATATTGCCTGGTGAGGACCTGATTACTGATGTTTTAAAGCTAAGCTTTCAGTTGTCACTCCACCCAGTAGTGAAACAATGAGCTCTAAAATATATATTTCGGCTCAAGCTTTCTTATGTGGGGAGGTAATCCACCCGAAGGTATCCCCAGCCTGTACCTAATACAGTGCCCAGCACTAAAGCAGCTCAGATGCCAGTGAATCGTGGCCACTCGGAGGCCTGTCAGTGGGTGCCAGTACCGGTCTCTTCAGAGAAAAAGAAAACTCCCCTCTGCCACATCAGTATTTTATGAGCTGTGAACCAAAACCATTGCTACCACCATCACTATAATTCTATCCACAGTAATTATCATAAAGGCCTAACAATGCCTTGTAGATGAACATTCTGAGTAACTGCTCTATAACCAGGAGATTTAAGACCGCACCAAAAACCAGTAGAGGGTTATACTTTACTGGGCACAAGTCGTTTATGAGAACGAAATTGTAGTTTAATCTGTGAAGAGATGTGAATGTAACTGAGACACGCTTAAATGGAATATACAGATGAGCTTTATTTTTATATCTGGCATGCTTGGATCCATGCCCACCCTCCAGCTGCTCGGGCCTGCCCTTAGGGGCTATGGACCGCATGACTCTATCAGCCGCACTGCCACCGCCGCCGCCTCCGTGCTGCCTGCGTTCCCCGACCATTGATTGGGCCCCGCAGGCGCTTCCTGGGCTTCCCTACCGGCTCCAGCCCTTGGGATTCGGGAGCGCCCTGCTAGGAAAAGCCAGAGCCCCGCAGGGGCCGCCGCGTCCAGGCCGCCTAACGCGCGCCCCTCGCCCGGCGCCCCGAAGCGGCCCCGAGGGGCGGGAGCCCAGGCGAGCGGCAAGGCCGGGCCGGGGGCGCACAGCCCCCCTAGAAGTGCGGGCTTCCCCCACCCCCCCCAGCGACCCTACCTCCCGCCCCCGCTGCGTGCGCCCGTCTGTCCGTCTGTCTGTATGCTCTCTCGACGTCAGTGGGAATTTCCAGCCAGGAAGTGAGAGAGTGAGCGAGACAGAAAGAGAGAGAAGTGCACCAGCGAGCCGGGGCAGGAAGAGGAGGTTTCGCCACCGCAGCGGCCCGGCGACGCGCTGACAGCTTCCCCTGCCCTTCCCGTCGGTCGGGCCGCCAGCCGCCGCAGCCCTCGGCCTGCACGCAGCCACCGGCCCCGCTCCCGGAGCCCAGCGCCGCCGAGGCCGCAGCCGCCCGGCCACTAAGGCGGCGCCGCCGCCCGGCCACCGCGCGCCCTGCGCTTCCCTCCGCCCGCGCTGCGGCCATGGCGCGGCGCTGACTGGCCTGGCCCGGCCCCGCCGCGCTCCCGCTCGCCCCGACCCGCACTCCGCCCCGCCCGCGCTCCGGCCTGCCGCCGCCTCTTCCTTCTCCAGCCGGCAGGCCCGCGCCGCTTAGGAGGGAGACCCCACCCGCGCCAGGAGGCCGAACGCGGACTCGCCACCCGGGTAAAGCCAACTCGGGCGAGTGGGGCCCCGGCAGGGGACGCGTGGCCCAAGTCCTCCCGCCCAGCCCTCCGCACCCCCTCCAGCCCCACTCGGACTTCCTCATTCCTGCGCTAACCGCTGGGCTAGACCGTGGGAGGAGGTTGACAGTAGCTGAGAGGCACATGGGATTAGCGACAGCGGGGAAAGACACATCCGGACCTCGCAGGGGCTAGTCGGCCAAGGGCCGCGGCCGCCCGGCGGTCATTTCTCTTCACGTCCCTCCGCCCGGCAAGGAACGCGAACCGGAGGGGAACTCTTACAAACTTTTAAAATCCCCAACCCCAGCCCCACCTGGGGGATGGTGAGAAGGTTGGAGTGCGCTGCGGCGCGGAGGAGACAGGGAAGGTGGTTGGTGCACTGCAGAACCAGATTTCACCTAGGGCGTTCCATGAAATGAAAGCAGAAGTGCTTAATCAGTCCTCTTGGCTGGGAAAGCCCTCCCCAGCTCCCCAGAATTGAATAGGAGAGTCTATTCATCCCTCTCCTACTTCTAAAAGAAACCTGGCTCGCTCTCTGTCTCTCTCTCTCTCCCCCCTCCCCCCCTCCGTGCGCCCCCCCGCGCGCAAACACACACACACACACACACACACACACACGATATAGTCACCTGCTATAGGACTTGATTCTGATCCTCCGGGGCCTGGCATTTGAGAGAGAAAAATAATTACCTACCTGGATACTTAGAGCACTTTTTACCTGCTATAGGACTTGATTCTGATCCTCCGGGGCCTGGCATTTGAGAGAGAAAATAAATTACCTACCTGGATACTTAGAGCACTTTTTTAAATGCAAGTTTTTCTATCCTCCTTAAAAACAGACACCAGGGAATGTTTGCCCTGACTTGCTGGTTTATCCTGAAACTCAAATCGGACTTAATGATACAGGATTTAATTATCAAGATTGACATGTTCATGGACTTTGTTAAGTAGAGGTTTTCAGCATTACAGTTTATGAAATAACCATATTTAACTCAAAGATTTTTTTATAAAGCTCATAATCTGAAAAAATGCTTATGGTATTACTAAAACATTTAATAGCTCTGGCATCAAAATATTCTACATACTGGTGATCTTTTAGTAAATAGTAAAGGTTAGGGTCAAGATATTCAATAATTTTTTTCTAGCAGAATCCCACAACTGAATATTGTCAAGCAGTTTAAACTGCATTCGTGTTTGTTAAAACTTTAAAAGGGAAACTTAAAACTAAGTATGTTGTTTTTCTGATTTTTAATATTGTGCTTTCTAGAGATGAATCCTTTTACTGTTTGAGGCACTATACGAATTATGTATTTTAAAGTATGTATTTAAATTTGAAGCAATGTACTTTTTTGAGTTTATAAACTTGGGAAGACAGGAAATAAAAAGATTTGTTTCCTGTAGAATTTTACATTCATGATTTAATTGAATTGCTAAAATGCACAACATGTACGATTAAATGGAGACTTGGAATCTGAGATTATTCATCCATATTGATACACCTGCAAATTCCTAAATGCCCTCCCCTGCTTGTTTAGATAAAATGTCTTCCTGGGCTGCAGCCTACTGGACAAACTTGAACACAAAGGAACACACGTTATATGTACATTTAATACTGGAACCGAAAAGCTGCTTGCAGTGAAAAGCAAACCACTTCTAAACTCTTTGAGACTTTTTAAAGAAGGTAGTATAATCCTTTTAGGGGTTGGTGGTCATGTGAAAATCTATTATCTTTTTGCTGAAAATTCATTCTTATGTTAGGCATTGGCACTCACTTGTGCTCAGTAAATGCCCGTGTTTTTCAAACCCAGATAGTAAAATACTGCGGGTATACATACAAAATAGTCCTTCCCCTTTGTAAGCATTGCTTTGATCTTTGCACTTCCTTTTTACTCTACCTCTTAAACAAGATCTGTGTTGATTGAGTTGATTAAAGCACAATTAATCTGAAATAGGCAGAATTTTAGATTTAGTGATTATATTCCTTACATTTCTGTTGTTACTGTTCCTGGAAACAAATTGAAGTAGTTTGAGAAACTAATATTTATGCAGGTTCTTTTAACTACACTTTTAGACTTGCAGATAATTCATTAAGTAAGTTACTACCTTGACTTTCAGCGATTCCTCATTGTGGTAGATACGAGGTCTAGATAGGGAATTGGCAGCTACATGAATGTTGGACTATCATTCCATCAGCAAGACCTTATTTTTACCTAATTTATGACAGGTATTTCTCTGTTCAGAAGAGAGGTGAAAGTTCTGGCTTCTGGGGGGAAGTGGTTACTTCATAACCTTCAATTGGTTTGAACTTGAGAAGTAAGAAAAGTAGTCGATATTTTCAAACAGTAAAATAATTGTATCTGAGTTGCTGTATGGATTTTTGATGAAGTACTCAAAATGTCATCTTTTGCATCTTCGCGTCTTAGTAGATGTGCTATTCTGAGTATACAATTGACTGCAGTAGGAAGTAATATCTGGAATCCACAGTACTGTTGTATAACCAATAGAGTAAATTCTCAGATTATGCTCTTCTGGTCCACAGATTGATCAGAAATCACATTAACAGGAATGGATCTCTATGCAAAATTTCTCATTAATTTTCTTACTTTTAGTACGAAGTTTGTTTTATTCGGTTGGTCTGTTGGTTTTCTGTTTACAAGGTGAATTGTCTACAGTACTCTCTTTGAATTTTGTCACTACTTTGGAGACAGACAGTTTGGAAGAACTGAAGGTACTCAGCCTCAGGGAGAAAGGTTTGAACGTTTTTTTGTGTCTAATCAGCATTAATTGATGACTACGTCTTGGTAAACAGTAGACCATACTGGAGCAATTTACTCTGCTTTTTGCCAATTAGTTCTCATTTGCACTCTTGCACCTCCCATAAATACTGAACTCACTTGTAGTGTTCTTAGAGGTCAGCAATAAACCATCAAGAGCATATGATCTCTCTTTGAATTTTGTCACTACTTTGGAGACAGACAGTTTGGAAGAACTGAAGGTACTCAGCCTCAGGGAGAAAGCTTTGAACGTTTTGGCATAGTCCTGCAAGTCAGTTTGGCTCCTTGACTGTGAATTTTTTTAATCAAAAAAGATTAATATTTGAAACCACATAATTTGGACAGTTAATAGTTCTGGTAACATAACCAAGCCTTTTATCTTTGTAGTATTTCATTAATTAGTACCAGTGCCTCACTTTTAGAAGAAAAAAAAGACAAAAAAGTAGTAACATTCTTTTAATCATQATCAAATTGCTTCATACCTTTGGTCTCTGCTGTATTAGGGGTTGTTCCTCGGTCCAAATTAATATACTGTCTTTTACATTTCCGGAGGTTGTTGAACCTGGCCTTGAAGATCACCCAACACTTTAGAAAATAAGTTGTGCAAATGCATTGCTACACCTCAAATAATTTAAAGCCTCACAGTTCTGTACACAATAACACTCACATACATCTGATTTGTTAAAAACATTATACAATCTCAGAAGATAGATTATGGATGAAAATATTTGTTTAATTTAGAGTACTAATAATAAAAATAGTGCATTTTACATTTTAAAAAGAAAACAATTTTTATTCTCTCATATTTTCTGTAGTAACAAACACAATTAATTATCAGTAATACAAATTTCATCTCCTTTAATTTATTCCCTGTTTTTGAAATTAGAATAATGATATATTTGGTTTAATTATCCATTACAAATTGCCTTATTATTTTTCATTCATCTTTCACCATTAATCCAGAAACCTTAAAATAGCTTTTATTTTGACCCATGCCTTCAGTAGATATCAACACACTTGAGTTCATCTATGGATCCTATTACTTTAAACTGTGACAAATTTTGACTGCTTAAGCTTTAGAAAAGAATTTATTCTTTAAAATAGCCAAAATTATAAAAAATGAAATAAAGAAAAAGCTGTTTGAGAGAATCAAATACTCTAGTTTAACTAAAAATAAATAATATCTAATCAAACTGACGAAAGAAAATATCTCATGCTTAGCATTGTACTTGTTGGTACATAGTAAGCAATCATTAACTGTTAAATGAATGAATGATATGAAGTTGTTGCAAAATTTTTTTTTAAATGGACAGCCATCTTCTATAAGGAACAAAAATTACATTATTTTGCTTTGCCTTCTGGAAAGAAAGGAGCACAAAAATAGTCCTTGTGTCTTAGATATTATGCAATCTTATCTAAAGACCACTTGAAGTTTACTAGAACAAATAATTTATTAAAAAGTATCTGGCGCCTTCCAAAAGGGGAACATTTCATTCTGAAAGAGGCATTTATGAACTAGAAAAAAAATGCCTTTTAGTTTCAAAGTTTTAGAGGCACCAGAGCAAGATTATAAAGTAATTGGAATGATAAAAGGTGCTTGTAAAATTGAAAAATCTAATTTTTTGCTGAAGTTAGAATTTCTGTACACTCCATTGAAAACTGTAATATCAATCTTTGTTGCTCCAAAAAAGAAACAATGCTACAAGCACTGCTTGGTAATCTAAGAATTGTTAACACTTATCTAAATTAATCAACCAAAAAGTTAAAACAAAATATGTTATTTTGTTATGTTACCTCTAGAATTAAACACCTATCACCCATAAATCTGTGACTGTTAAAAGTTACTAGATGGCAAACCTCAGGAACAAGCAGGCAGTTAGCAGGGTTTACTGTACTTTCCACTTTCATACTTTAATGATTTTTCCAACACTATAGAAGCTGGGGCCTCATCCTAGCACAGTTTGTTCATTATTTTTCAGTTGTAGCATTTTTTAAAAGTTCGCCTTGAATTTCTGAATTGAACCATTTATTTTTTTGTGGACACAGTTTTTTAAATGAAATATACCATTTAGACTAGAAAAGAGCAAAATGCCAATACTCCCTGTCCTAGTGTCATTGTGCCCCCTGCGAACCCTAATGCAGTCCTGTGGGAAAACAACCATTTTATTGACCGCTGCTCACTTCAGTTCATTCTGCTTTGCTGCCACTTAGTTCTGGTTCTGACCCTGATCTCCCCTCACATCACTCACAACAAACATTCAAGTTTAAAAAATTAAGTTAAAAGTTAGTTACATATATATGTACTAATGTGTATATTAAATATACTGATATATATTAGTTACATATACAGATATGGCAACAACAAAAAAGGTTATATATATACATATTTGTAACTAATATGTATATTAAATATAATGATATATGTATAATACATATTTGTAACTAATATAATTATATTTAATATATATTAGTTACAAATATTGTATATATAATATTTTTGTTGTTGCCAGCAAAATGAGAAAGAAATTAAATGTTAACATCTATAACAATTGCACTGTAAAAGCCGTCATTGTTCAAAACTACTCCGAAGATTAATAGCGGCAGTGTTTGTTAAAATAATAAAATAATCCAGGCACTCTGCCTGTGACTTCCCCATGAGATGGCTTCCAGAAAAAGATAAATTTTTGTGTGTTCCCTTACGAGTTCAGTCTGCAGCTTCTGGGCATGAAGAGAAGCATAAACAAAACAAACAAGGCTCTAACTTTGTTATAATCCTTACGCTACTAGTAGAAATGTATGGACAATTCATGCATTTCATATTGGAAAATAAAGCTATTAGATTTTTCTTTCAGATGAACCTTTTTTTTGTAATTTATTTTTTATTTTTTATTTTTTTTCAGTAGAGATGGGATTTTGCTCTGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAAGTGATCCACCCGCCTCAGCCTCCCAAAGTGCCGGGATTACAGGCGTGACCCACCTAGCTTGGCCAAGGTGAACCTTTTTGATAAATGATTCTCACTAATATTTCTAGGATTTACTTTTCACTAACTTGAACTAAAGAAAGTATAAGACCTGCATAAAGTTGAGCATACCTCTATAATCTCCCATTTTAAAAAGCAATTTGTTTTTAATGACTTTTATTTGTTAAAAGCAGTTATTTCAAAAAATTATTTTTATTATTTATCATGTCATTTGGACTCAAAATACTATACCATATTTCAGTGTTAGGGCACACCTATCCCTCTTTATCCCAGACGTCAATTCTACCATATAACAAGTATGTAAAAAAGAAAACATAAAAGTGATGACAGACTCCCTAATCAACCTATTTATTGGTTCTAAGCCCAAGCCTGCAGTTCATTTAAATAGTGAAAATAGATTACTTAATTGTCTTAGAAAATATGTCTTCCATGACAAGAATTTTAGGAATGACAAAATAACTATTTTTGGATGTTTTAACACAAATTCCCAAATCATGTTTTATTGATATTTGAAGAACCTCTTTGTCTACCAGTTCTTAAGTATAGGCTTATTTTCTAAGGCTTAAACATGTATTGGTGTTTGACTGTTAAGACTTGATCTATAACCTTCAGTGTCTTTTTCTTTTAAATGCCGTATGGACTTGGTAATGAGGCCACACCAGAATACCTTACAATTTATAGCATCTGCATATAATACAAGAACCTTCATGATTTATAAAATTAAAATGATGATGATGTGGAATGATGGAAGAAGCATGTGTGGGTGGCTATTTATGTAGAGGAAATTAGAAGTTGAAAGCAATGTAGACGTCAATTCTACCATATAACAAGTATGTAAAAAAGAAAACATAAAAGTGATGACAGACTCCCTAATCAACCTATTTATTGGTTCTAAGCCCAAGCCTGCAGTTCATTTAAATAGTGAAAATAGATTACTTAATTGTCTTAGAAAATATGTCTTCCATGACAAGAATTTTGGAAATGGGAACTACTTTTCAGAGGAGATGGCTTAAAATGAACCAAAAATATAGCCATTTCTCTACCCTATTCATTTAATGCATTCATTTATTATACTGCTAATACATGATAAGGTGAATAGGTTAAGCATCGTTTGTATATGTGTATGTGATTTTAAACCTGAGTCTTTTGAAAGATTGGTCAAAGCAAAGGATAATGAAAGCATAAAGATTTAGGGGGAAGAGTCCTCTATAAAACTAAGACTTAAACTTTGTTATCTACTTGAATGTGAAGATAGAATAATCTAGAAAGTGAATGAGAATTATAAATAAAAGGACAAATCATATATCTCATGCTTGACGAATACAATGAGATTAATTGTATATCTCATCTCATGGAGGGTCATAATGAAAGAAGTAAGAGAGATTGCCCTTGGATAGAACCTTTCGGCAGACATTTCATAATGGATTATCATATTTTTGCTAAACTGGTAAGAATGGACTTTTCACCACATTATGAAAAAACACTTTAGAAGTCAGTTGCGATCAAGCAAATATAAGTACCTGGGAAATTAAAATCAGCACAGCAGTCCAACAATAGTCAAATGCATTTACTCACTCTCATACCATATCATACAAAATTAATTTAAAGATAATGTCTTTATGGTGTCTCTTTATATATTTACTCGATTTCCCATTTAAGACATTTAACCAAATTTAAAAAGCAATCCTTAGAAACTTTAAAAATATTTCCTATTTTAAACCATTACATAATCATTTACCCTGCAGTTACAATTCTTTTTTTGTGATGGGTGGGGAAGTATCCCATTTCTCTTAGAAAGTCTTCTGTAATAGCCAAATAGGAGTCAATCCAAGTTGCTTAGAGAGGTAGTTCAATCCTGTGTTGAAATAGATGACTTTTCGACTAATTGTGCTATATTTACTGAGTATCTGTTGAACTGTACCAGTCCAGTCATTCAAGGCAAGCTAACAAGAAAATTTTATTGCTGAGGCACTTAAGTATCTTCACATCTATATGCCAATATTAAATTTCTCATCATCCTTGATCCCCACCCCTTTGCACAGATTGGTATCCCCAGCACATTAGGGAATGCGGTTGTTAGCCTGTTAGGGTCCATTCAGTAGATTTCTCATGCCAGAAATCTAGAAGCCCTTCTTATACATTCAGCTTTCTTCTTCAGTCAGTCACCAAGTTCTATCAAGGCAGCCTCCTCATCTCCACAAATCCATCCCTTCCTCGTTGATTTCTAGATTTTATTTTTGCATTGTCTCCTGCTTCTAACCCATCGTTCATTTCGCATAATGGTCAGCTTTCTTAAAGTGTAATCGGATCATGTCTCTGCAGTGAATCCCAGTTGTCTTCACAAGCTGATTCTCGCACACCTCACCCCCTTACTCCCTCCGGTGTTCCCCAACCATCCCCTAATCTCAAATCCTCCACACCGACTTTCAGTTTCCTATCCACAGTTTCTGACTTTGAATGCCTTTCCTTATGCCCTCCCTGTATGAGAAGTGCCTTTTCTTTCCTAGCCATCCTGCTAACTTCTAAACCCTTAGGCCTGGTTTGAGCATCACCATTTCTCTCACTTGCCTTTCTGTTTTCTCCCTAATTAACTGTGTGGCTCTGAGCAAGTTAATTAACTTCTCTGAGTCTTATTTTTGTTCTGTAAAAAAAATGAGGTTTGACAAAATGAGCATTCATCTTATTTACTTTTTATTTGCACAGCACCTGGTCTGTTTGCTGAATAACTAAATACCCAACAAGATATCAACAGACAGTGCTGCCAATTAACTGTGTGGCTCTGAGCAAGTTAATTAACTTCTCTGAGTCTTATTTTTGTTCTGTAAAAAAAATGAGGTTTGACAAAATGAGCATCTCTCTCTAAAATTATGTGTTTCTTTGATGTAATTGTATTAATTGGAAGACTTCAGATTTTCTTGCCATATCAAGATAGGTCAACTTAAGAAAAATGCATQTGAGTAAGTACCAAGCCAATTCTTGATTATCAGTATGATAATATGAGGAACTGCCCATTTTGTCGATAATTAGTTATAATTTTTGGTCTCAGTGTAGGTTCTTTCTCAAATCCAGATGTTTCTCGTGTTGCATTTTTTCATTATTATTCAGTCTCTCGCATTCATATTTCTCCAAAGAAATTTATGGAAAACTTGAGACAAAAATTGAATGTAAAGTTTAATATTTAAATGCTAGATTGATTCAAGGTCTCACTAATTATAACTATATTTGGAGGGAGAAGAAGGGGAGGTGGTGGTAGTATGAGCTGAATCCTCCTCTGTTCCTTCCTAGAAGGAACACAACGTCCTACATCAAGAAAAAAGACAGAAGCATATCTTGGAGATATGAAAAGAACCACCAGGTAAACTAAAAAGAAAAAGAGTGTTAAAAAGTCAGCCTTTAAAAAGCACGATTGGAGATGAGGAGGGGTGGAGTAGGGGAACCATTCCTTGTTTATACAAGCTCTTCCATCTTCGTATAGTGTGATTTTTATTTTTTTATTATTTTTTCVCTTCCTTTTTTTTGACCTCCAGCTTTAGTATAGTACAGTTGACAGAATTATATATGTTTATGGTACACAAGATGATGTTTTGATATACATATGCATTGTGAAATGATTAAATCAAGCTGATTAACATAAGTAGGGTTTTATTTCTTTAACAGTGATTTATTTGAATATATGTTGAGTCCTTTCTATGTGCCAGACACAGTTCTAAGGACAAGGCACACAGTGCCAAACAAGACAGAAATCCAGAAATTCATGGAGCTTAAATCATGTACTCTTTTCAGTTTTTAAAATTTTCTTCCTGGGCGTAGTCGCTCATATCTGTAATCCCAGTACTTCACCACCCCGAGAACCCACCATTGCTTAAACCCAGGAATTTCACACCAGCATCGACAAATAGCGAGACCCCAAGTCTCTACAAAAAATTTAAAAATTAGCTCCCCATGGTGCCACATGCCTGTGGTCCCACCTCTTCACCAGGCCGAGGTAGGAGGTTCACTTCAGCCTCCGAGGTTGAGGCTTCAGTGAGCAGCGATTGTGCCACTGCAGTCCAGTCTAGGCAACAAAGCAAGACTGTCTCAAAAAAGGAAAAAAAAAATTAGTGATTTATCTCAAGGTCAACACCTTTAACCTAGTGGGTGGTCAAGAAATAGAACACTGGCAGCACTGCAAAAGCATCCTATCTGCCCTTTCTTACTTAGGACCCCTTCCCTCCACTGTCATTTAAAAACATTTCACAAACAACTTTTGGATTATATGTATGTCATTCTGTCACTCATATATATCCACATAGACAATGGAGCGTTGACTGAATGAATTCATTATTCCAACGTCCTAAATAATGACCTTCACACCAGCGCGACTCTGCTGTGTCAGTTGGGCTCTAAGCTCAGTTCATTTCAGATATTCCTCACTAAACAAAATACTGTTTTTCCTCAGTTGTTAGTAAAAAATAGAAAACAGATTACATTCTCATTTACTTATTACTTATCAATGTAAAACTAATTATTTTGCTTAATACCAAGTAGCCACGCTCACTCACAGAGACATGGGACAAACAACTATTCACATCTCATGTTATCAGACATAGAAGAGAGAGGTATACTTCACCTATTTCTCCCCACTCAGTTTATACATTCACATCTGTATGTGTGTTGTTTTGTTTTGTTTTGTTTGTTTCTTTTGAGATGTGGTGTCGCTCGTCACACACGCTGCAAATCCAGTGGCCCAATCATGGCTCACTGCAGCCTCGACTTCCTGGTCCCAACCTATCCTCCCACCTCAGCCACCCAAGTAGGTGGGACTACACGCATGCACCACCACACCTGGCAAAATTTTAATTTTATTTTACTTTTTAAAATTTTTGTAGAGATGGGGTCTCCCTATGTTGCCAAGGCTTGTCCCCAAATACCTCGACCTCCCAAAGTGCTGGGATTATAGCTCTGAGCCACCACACCCAGCCATGTATATGTTAAAGCCTTTATCTGTATGAGTGGTCAGTGTAGAAACCGCTTCATGGAGCCTGATTTTGATGGCTTGCAAATTATTATATTTCTCTATGTCTAATCGGAAGGCCTTCCCCGTGATTATTTCTTCAAAGGAACCCTTTCTCCCTCCAGGGTGATTGTACCCATGTTCATAGGACCAAACATTCCTCGTTCACATAATGACTCTTTTTCTTTTAAAACATAAAGCACATATTTTTATGGATTTTTGAGGATTAATAGAATAAAAATCTAAAGTCATATTCAGATTCAAGAGAACTGGATCAGTTTCTCTGTATTTCAACAAAAGAATACTAATCTCTAATTCATAATGCATGAGGTCTACTTCTTCCTCAGTCTGAAAATATGAATATTCCAAAATGGTACTCAAGGCAGAGGCTATATATCAAAATTAAAATTCTGTGATACTATGTTTTTAGGGAAGAAGAAAACTGTAGCATTAGAAATGTAGACGCAAAAGGTCAGAACAAAAGTCCAGTATGTCAAGTCCCTTTATAATGCCATCTGAATGAAGACCTCACACCATGAACAGAGGTATTGAAGCAGTTTTTATGTGGAAATGGTAGGCAGCAATATCTCAGGAGTGACTTTAAATTATACATTTAAGGTTTTATCTAACTTATTATAATCCTTAGAGAACTTCTCTAGCTCTACAAGTTATTCTTGGCAGAATTTGTCCTAACATAGTATTAATAAAAATAAATTTTACTTGAGTATGATATAAATTACTCTTAATTACAATATAATTTTAAAATGCCCAAAACATCTTTTGATCTTATGAATTTCAGTCAGCTATGATTAAGAAGACAACCATAGGCAAAAATTTCTTTCTTATGGAACACGTTGGAATGCATTCTAATCACTTCTCTAAGAAAATCCCTGTCCCCCATGATTATAGTCAATATGATACACCAATAATTTAGATGCTTCTTTCAGGGGGGTGACGTTATGTATTCTACAGTCTATTCATTCTAAGAGGCACTTTTTTCTCCCCCAATTTAACAGTTTTCTTTAATTATATACATTTCAGGATTTTTTGGGGATATTTTTCTATCACTGGTTTCTGATTTAATTCCACTGTATTTAGATAACATATTCCGCATGCTTTCAATTCTTTGAAATTTATTGAGACTTACTTTATGGCTCGCGACCTGGTCTATCTTCGTGAATATTCCGTGTGTATTTAAAAATAATGTGGACTCTGGGCCGGGCGCGGTGGCTCACGGCTGTAATCCTAGCACTTTGGGAGTCCGAGGCAGGCAAATCATGAGGTCAGCACATCCACACCATCCTCCCTCACACGGTGAAACCCCATCTCTACTAAAAAAATACAAAAACTTAGCCAGGCGTTCTGGTGGGCGCCTGTAGTCCCAGCTACTCAGGAGGCTGAGCCACCAGAACAGCGTGAACCCAGGAGGCAGAGCTTGCAGTGAGCCGAGATGGCGCCACTGCACTCCACCCTGGGTGACAGAGCGAGACTCCATCTCAAAAAAAAAAAGAAAATAATAATAATAATAATGTGGACTCTAAAATCATTCAGTGGGGTGTTGTAGACACACTAGCTTCTTTTGATTGACAGTTTTGTTCCTAAGCCTTCTATATCTTTCCTACCATCGTTTGAATGTGTCCCCACCAAATTCAGGTGTTGAAACAGGATGACCAATGTGATGGTAGCAAAAGGTACAGCCTGTAAGAAGTGATGGGATTAGGTGCCCTTTTAAACGGCTTGCTGGAGGAAAATTTGTCTCCTCTTGCCTTTCCGCCCTCTGCCAGTTGCGGACACAGCATTCCTCCCCTCTAGAGGATGCATCCCTCACCAGATACCAAATGCTGGTGCCTTGATCTTGGGCTTCCCGTTGCCAGAACTGTGAGAAATAAACCTGGGCTCTTTATAAATTACCCAGTCTCAGCTATTCTGTTATACCAGCATTAACACACTAACACATTTCCTGACACTCTGTTGATTTGCTTTGATCAATTACCGAGAGAGGAATGTTAAAAATCTTAACTGTAATTGTGGATTTGTCATTTTTTCCATTAGTTCTGCCACGTTTTTGCTTCATGTATTTTGAAGCTTTGTTAATAGGTGCGTACACAATAACATCATTGTTTTTCTTTGATCAGTTGGCCCTTTGATTCTTATATGCAATGTTCCTCTTTGTCCCTGGTAATGTTTATTCTCTTGAAGTCTACTTTATCTGATATTTTAGAATGTAGCCTGCTTTTCTTATATTTAGCATTTGCATGATATAACTAGCCCACTQTACCATCTTCATACATTTAAACTGTGTCTTTAATATTAAAGTACAATTCTTATGAAAACCGTATACTTTAATCTTGTTTTTTAAAAATCCAGTCTGATCATCTCTGTCTTCTAGATGAGTTCAGTCCACTTCCATGTAATATTATTATTATTATTATTTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTCGCTCTGTCGCCCAGGCTGGAGTGCAGTGCCGGGATCTCCGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTCCCTCAGCCTCCCAAGTAGCTGGGACTACAGCCGCCCGCCACTACGCCCGGCTAATTTTTTGTATTTTTACTAGAGACCCGGTTTCACCGTTTTAGCCGGGATGGTCTCGATCTCCTCACCTCGTGATCCCCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCCTGAGCCACCGCGCCCGCCCCCATGTAATATTATTACTGGTATGTTCGGTTTAAGTCTCTCATCTTGGTAATTAATTATCTATTTGTGCTATCTCTTCTTTATTCTTTTTTTTCTCCTTTCCTGCCATCCTTTGAATAAATCAAGTTTAGTGTTTTAAATTCCATTTTATCTCCTTCATTGGTTACTTTCTAAAGTGGTTACTTTACCACTTTAGAAAAGTATTTGTTTATTACAATATGCATCTTTGAGTCTCTAATTAATGTGAGAACTTGACAATCTTATACTTCTGTTTGTCCTTCTGTGCTGTTATTGTTATACATTTTACTTCTTTATATGTTATAAACTCCAAATATATTCTCTTGTTTTGCTGTGGAACACTCAATCGTCTGTTTACCAAATTAAGAAAGAAGAAATAAAAGTCTTCTGCTTACTCACATATTTATCATTATTGATGCTTTTTATTCTTTCATACAGGTCCAAGTGTCTATCATTTCCCTTCAGCATGAAGAACTTCTTTTTAGCATGTCTTTTAGCAGGTCTGCTGGTGATGAATACTCTTAGCTCTTGTTTACTTGAAAATGTCAATTTCACCTTTATTTTTAAAAGATTTATTTGCTCAATATTCTGGACCAATCTTTTTTTTTCTTTTATCACTGTAAAGGTGCCTTTACATTGCCTTCTAGCTTCTACTGTATCTAATGATCATCAGACATCATGCTTATCATGCTTATCAAATTGTTCCCCCATAATATAATATGTCCTTTCTTGTCCTTTGCTATTTTGGGATTTTTTTTTTCTCTAGCATTAGTTTTTAACAGTTTGGCTGTAATATAACCTAAAATGGTTTTATTTGTCTTTATCCAGCACAGAGATCTTTGAGATTCTTGGATCTGTGGGTTGATTTTTTAATCAAATTTATAAAAAAAATTCTCAACTGTTATTTTTTTGAATATTTTTTCTGTCTTTTTTCTGTTTCTGGGATTCTATGTTAGLAATACGTAAGACTGCTTAATATTGTCCTGTACGTCACTGAAGCTGTGTTCACTTCTTTCTGCCTTTTTTTCTCTGTAATTCAGTTTGGGTAGTTTTTATTGACCTTTCTTCTAGTTTATTGGTACTTTCTTCTATAATGTTAAATATGCTAAGTCCATCTACTGAAATTTCATTTCAGTTCTAAAATTTCCATTCTTTTTTTTAAAAGAAAGGTATGCATTTCTTTGCTCATATTGCCTATCTGTTCTCTCATTATGTTCATCTTTTCCTTTACATTATTGACCATATGCTATTAGCTATTTTTGTCATTTGTGTCATTTTTTTTCTCAGTCTTATTTTCCTATTTCTTTGCAGGCTTCATTATGTTTTATTGTACATTGTGGAGAGTTTGCGTTTTTTGTCTTCCTTTAAAACGTGTTGAGCTTTGTTGTAACAGGCAGTGAATTTACTGGTGGATCACCTAGTTTTATTAAGATAGGTTTAGAGTAGCCCTTATTTTAGGATGTTTCTAACTCCCATCGTGTGGTCTTTCTGAAATCACAACTGAATGCTCACAATGTTCACTGATGTCTTTCCACCCTGGATTATTACAAATTCAGTGTCTCTCAGCACTATATGATGTCTGGAATTTCCATTTAGCTCTTACATCCCCAGAAACTGTTTTCTATTAGGTTTTGCAGGGTCTTGTCCTACACTATCACAGCTTGGTATTTGCCCAGTGACCAGAGATGACCCCTATCTAGATTTCTGAGGCTCTTGCTTTTTGTGTAAAGCCTTTCTTTGTGATATTCTGCCCATTGGTGTTCTCTCTTTGGCCTCTCCCTGTGTCATGATTTGGAAAGTGTCCTCAGTCAAAAAGTGAGCCCGAATTTAGAATTTACCTAAATCACCTTATAATATATAGCCCTATCAAGTCCAATGTCTTAAATTACATCTTTAGGTATTTTCTATGGTTTCACAGTTGACTATAGCAAGGACCCACGTTCAGATAACTGTTGGTCTGTGATAACTAAAACCAGAATTTGACATTCTGACAAACTTGAAATTGCAGTGCTTCTTAAAATTAATACAGTATTACTTAAAAAACAAAAACAAAAAAACCAGTGTTTTCCAATTTGCCAATACAAAAAAGCAAAACTCCCATCTCTACTTTTTAGGAACTTCTATCCATTTGAGAAGATGATAAATATATAGGTAAAGTTAGATTGCAGTAAAACTATGCTGTCTAGTGTTAAATCACCAGTATATATAAGTTTTATAGATATTATGTGACTACACACCTATAGCTTATAGGAAAAATATACCATTTCTTGGCAGAAATTCCATTTAACTACAGCCTTGAAGAGTGGATGCTATTGAGGTAGAAAAGATGGCATTTCAGGATGCAGGGCATATTGTGAACAAATGTACAAGATGGAAATGAGCAAGTCATTCTGAAATGTTAATCTGTCTATCATAGAGGGTTTGATTAGGACATAGTAGTAGTTGATGCTTATAATATGATTTAATATAATAATGTAAATGTGCTGAGTGGTTGAAGTCTTTGGACTTTATCTTATAAGTAATATGGCAATAATGTGAAAGATTCTTGAAGAGGAAGAAACCCTGCAGTGAGGGAGAACAGTACAGAGCCTATTACTGTCATTCAGAGGTGAAGCAATAAAGGTCTCTCCTAGGATGTTGGAAAGAAGGGGCAGATCCAAGAAACAACATGAACAAAATAATCAGCAGAAATTGGTTATTGACTAGATATGTGAAAATGATATATTGGCAGAAATTGCAAAGGGTCAAAAATGGGGCTCATTGCAGCAGGAATGATGAAATTGCTTTTAGATAGACACGTGAAGGGATTTAAACATTAAAACTTCTTTTAAGCTATCACTGCTTAAAGCTAACAGTCATTTATTAATATTTCCACTCTCAAACTTTTAACAGTTTTAATTTTATGTATACACCACAGTGTTTTCGCTACTATACTTGCCTCTTTTGTTCAGTTGGGAATTGAGTAAACTAATAGAGTAAAAAAATGAGTACAAAGTGGGCTTTGACTAGAACTCTAACAAAGTGTGATCACTGAATTACCAAGATAATTAACCCATACCCCACATATACTCCATTTCCCATCACACATATTATATTGCATTGTTTTTGCCTATTTCCCTTCCTACTTCCTAAACTGTTGAATTAGTTTGCTTTTGTTGCATTAAAAAAAAGGAGAATCACCACAAAGCAAATTAAAAGATACTGATTACTTCTTCCAATTCTGTGCCCTGCCTAGTTCATCTCCCCTGCCCTGCTTTGGCTAATCTCTGAGGTCTTTTCGCTACTTGACTGGTACTGTTTGTAGCTACTCAGCTCCTGCCCTACTGCTGTTTGTCTGAAGTTGTTTTGGCTACTCAGCTGGTGCTACGCAGCCTCAGCTAGGACTGCCTGTCTGTGCTCCACATGGTCTTTGATTTTCCAGTGGCTGGTGCAGGCTTGTTTGCATGGTAACAATGTTCCAAGAAAGCAAGAATGATCATTGCAAGGCCTCTTATAACCTGGGTTTAGAACTTGTACTTCTACCTCTTCCTATTGGTCAGACTATGTCCCTAGGTCTGCCAAGACTCAAAGCACAGAGAAATAGATGTTTCCTCTTGTTGAGTGGCATATAAAAAAAAGTGTGGCCATTGATTTCAATCTGCCACAACCGTAAGCTCTGTGACTACAGGAACTGCATCACTCTTTTCCACTTTGGTGTTGTTGGCATACTACACATAAATATTTTTAGGTCAATAAACTAATTAATGAACGAAGGAAAACATTCAGGTAGTATTTCAATATACTGTAGTTTTAAATTATATATATTATATACATTTGACATAGTTTAATATATAAGTATATACACATATAGTTTTCATATATAAGTATATTATATATTATATAAAATATTTATATGTTATATATAAAGTATATATATAAAATATATAGTTTTAATATGTAACTATATGTATATAATTATATATAATATTATAAGTATATATACTTTTATCATACCATCAGTGAGTATAGACATGGTTCAGGGAGAATCTCTTTATTCTCCTTCTATCTTTTGAGATAGACCAAAGAAAATTTTTTTTTAAAAAAGGAACTATCACTTGAGTTAACATTGTTTGGTATTTTTATCTTCATAGGTGATTGCCTTGTGAATAACTCATTTTGTGTATTGTCAGAATCCTATTCTGCTTTTCAGGCTGTGCTATGGGTAGACTAGCTCTAACCAGAACACTTGGGAGACCTGAAGCAAAGATACTATATTAAAATAAGTAATGTTATATGCCAAAGAGGAAAACCACTTCTGCCTCCTAACACTGAAGAACCAGAGACTGTQGGGTCACATTAGCTAGCATTACTATATGTAAAACCTGAGCAAATGACTTACTCTCTTTCAGCTTCAGTGTCTTATCTAGGACATTGCTTCTCAGGATTGGTGTGAGAATTAAACAGAATATGTGAAGTTCTAGCTACAGTTCTTTACCCATGACGTAGTCAGTAAGTTTACTTCTTTCTCCATGTGAACCAAAGCACTGTCATGATGTGAATGATGTTCATTAGGGTTTCTCATGCTCACCGTTATTGATATTTACCGTTGCATATGCTTTATTGTGAGGGGCCATTCTGTGCAAGTATAGGATGTGTAGCAGCATCTGTAGCCTCTATACACTAGATGCCAGTAGGACCACCTATCCAGCTGTGACAGGCAAAAATGTCTTCAAACGTTGCCAAATGACCCCTCCGGGCAAATGCAAACAGTTTATCTAGCAGTGACACATAGCCAGCCACCTTACAAGGGAATTGTCAAAGCGTACCCATAAGTGTAGAATGGGACALAATACTTGAGTCTTCTCAGAATGTCTAAAACCTTTTGCTGTCTATAATTCCTCTTTTTATAATTTACCAGAAACATATATTGCTTATTATGCCATCTAATAAAATGGCTAACATTTGCTGTGTATTATACTCGGTGTTAATAAGCTTTGTATGAACTCACTAGCTGAATGTTGTATATGTATCTGCCATACCTGTTGGATTGACATTCCACTGTAAACAGGTACCTTATCTTTACCAGCTCCAAGCACAATGTATTTGGTATATCAGGTAGCTATTCTACATGTTAATTGATCACATTGCACCCAAATGAAACATGGATGTGGAAGTGGAAGGAGGAGCTTTAAAACATGGAAAATTAGTTTATACAAATCTAAATGTTGTAGTGCACCAAATTGATTCCTTTTTAAAAACTTTCAGAAAATCAGCTTTAAAAAAAAAAAGTAACTAAGCCATGATCAACTTTTCTTTCATCACCACTAAGCCAATATCAGAAAGTTGTCAATCAACAGCTCTTTTAAAGTTGAAATTTTTCTATTGTATTTCTTATCAAGATTTCAGTAGTGCTTAGAAGTTTTTGGCTCATTTATCATGTTTTATTCACTGTATGTCATTAATTGTTAAAGATGTCAGAGTCAAACCTTAAATTCAGGAGAGATTTAAATTTTTCCTTTTTCCTATTTAAATATATGTTTCTAATTACATAATTCAGTTAGAAAATTACAATATAGAAACATATAGACTTAGTAAAGTTTCCAGTTACTGTATACAGATTATATTGTATACTGTATTATTTTTAACAGTTGCATATTTAACTTATAAATGTGGATAATTATAATTAAACAATCTGTTATCAAAGGACATACAGATTATTTCCAGTTCCTTGCTGCAGTGAATATCCTTGTACTTATTTTTTTACACACTTGCTCAGATAATTTTTAAGTACAAATTCCTGAGGTAGAATTGCAGAATCAAAAGATACTCTCATTTGAGTGTTTCACATTTTATGCAAAGTATTTTGTTTCCTCCAGAAAATTCCTCTGTGGAAGAGGCTTCCTCACATTCTTTATCAGTTTATTAGCCAGCAGAGAAATGATGAAAAGCCACCCCTTTTCTTGTAGTTTCATCCTCATTGCTATCCAAGATGAGGTATTAAAATCACACCTAAGTGGTGTCTGTTGTGGCTGAATATAATCTTGAAAGTAGAGACACTTCTCTCTGATTCCCAACTGTACTCTCTGGATGGCACCTAAAATTTTATTTTTTCAAACTGAAAATCATTTTAATGAGTTCGAAAAGGTTTTATTTTTTTAAAATGAATCCTATAGAAAGAATACATTTTCTTACAGTGGGTCATGGTCALAAGTGTGAATATCTCTGATCCTACTTAGTTTCCCCAGTTACAAGGACAGGCGTGCCCCCAACTCCATCCTTAATGGCTCAATTCTGTGGCTTTCAAGTTAATCCACTCAGTCCTACAGCCTTCACCAAGAAGCTCATGTGCTACACTTTGGTGTTAGTGGGGGCATTGTCACACAGGTTCAGAAAATAACCCATTAGGCATTTTATAGAACTCATCACATGTTCAAACTAAGCTAGTTGTAACATTATGTTTTTCATGTGAAAAAACACAAGCAATTCACTGGCTATTTTATTTGTTGCTAGCTATGCTATACTTTCTATTTCTTTTTCCATGGTGTGATCTTCCTAGAAAACCTCACTACTGGGAAAAGAGATGCAGAGATTAGTCCCATCTAATCTCCCCTGCAGAATCAAAAGATACTCTCATTTGAGTGTTTCACATTTTATGCAAAGTATTTTGTTTCCTCCAGAAAATTCCTCTGTGGAAGAGGCTTACTCTCTGGATGGCACCTAAAATTTTATTTTTTCAAACTGAAAATCATTTTAATGAGTTCGAAAAGGTTTTATTTTTTTAAAATGAATTGCTTTTATAATTAATGCAAATATTACTTAGTGATTCATCCTTTCCAATGATTCTTGGTTTCTTTTGACATTTCATTTTTTAAATTGTGATTAACATTGACATCACCATAGCGTTACTGTTACCTCACCTCTTTACAGTGAACTGTATTGCAAAGCCTATAAAAGTTCAAATTTTTAACTATCACCCACCTGAGCCTTGGACTCCTGTTAGGCTTTTGAACTCTGATCCTTTGGCAAACATTGGTGTATAATCATTTCCCCACCATAGAAACGGTTAATCTTTTCAAGGGAAGTGAAGCAACTCGGAAGGCCATAGGAATCCACATCACCTGAACTGCAGACCAAGCCTTGGAACTTTGTTCTGTGCTCCACATGGTCTTTGATTTTCCAGTGGCTGGTGCAGGCTTGTTTGCATGGTAACAATGTTCCAAGAAAGCAAGAATGAAAAACTGACTTACTCTCTTTCAGCTTCAGTGTCTTATCTAGGACATTGCTTCTCAGGATTGGTGTGAGAATTAAACAGAATATGTGAAGATTTTCACCCACCTGAGCCTTGGACTCCTGTTAGGCTTTTGAACTCTGATCCTTTGGCAAACATTGGTGTATAATCATTTCCCCACCATTGTGGTATTCTAGGATAGCCATTTTGACATTGATTGTTCTAGCTGGTATTCACTACTGTATTTAAAGTGTAATCTTTTTACTAGTATTCTTCTCTGACTTACTCTCTTTCAGCTTCAGTGTCTTATCTAGGACATTGCTTCTCAGGATTGGTGTGAGAATTAAACAGAATATGTGAAGTAATCCTTGCTGCAGTGAATATCCTTGTACTTATTTTTTTACACACTTGCTCAGATAATTTTTAAGTAACAAATTCCTGAGGTAGAATTCCATTCCATCAAAATCTGTCATTTTTACAGATGAAGAACAGCCCACAGTGAGTTTAGTTAATATCCTAAAAGATCACACAGCAAGCATGATAGAACTCTTAAATTTCAAGCGACTTACCCTCTTTACTCTATCAGGTCAAATTTCCCTTTTTTTAACTGCTTGTCTTAATTGAGATTTTTTAATTGTGGCTGTCTCTATATCTTCAATCAATACTTTCTTGTTTTAGACATGTTTCCCTCCAAATCTGCATGGAAACTTCATGTTCTGAAGGACTCAGAGCTGCCCTTTCCTTTTTGTTAAAGTTGTACACTGCTCTGCATCCCCCTAGAATGCTCATCAGCTTTCTCACTCTTCCTCACTCACACAGTGCTCCAGCAGGAGAGGATTTCTTTGAAAATCAGATTCTTTTTTGGAGGGCTTTGTGCTTATTGGAGTGTTATGTGATATATTCATTACGGTGAGGGCTAAACTCTTTGAACAAAGAGACCTGACAGTGCATTTGGGTTAAAGAACAAAGTTTATTTCTTTCTCTCATCACCACCACCATGAGCAGCCTCGATGCTCAGAGCAGATCTGTCTCATGGCATTGTTCACCGATCCTCATTCCTTCCCTCTCATTTATCTGCCATCCCCTACGCTATTAATCATCATGTTTTTCGTACAAAGCCAGGTCTTCTCCATGTCTGAGTTTTTATGGAGG1AAGCATGTCAGGCCTTAAGCCCGTCCTTGCTGCAGTGAATATCCTTGTACTTATTTTTTTACACACTTGCTCAGATAATTTTTAAGTACAAATTCCTGAGAAGTGTAGGGTATACACTAGGTAAGCAGTCACATTTCCAGCTACAATACTAATTCTATGGAACGAGACAAAACATATTTTGATCGCTACCTTTATTTGAATAATAATAACCACATTTCTCAAGGAAGTAAATCTCAGAAGATATCTGATTTTAGATACTATCTTTATCTGACCATGTGGTTCCTTCCTTCTATCACCGAGGGCCTCTCGGTAATAGACATTGCTAGCGCCTCCACTATATTTTGTTTAGCTGGAGTTGATTAGAAATCTGAGACCTATAGCCTTGATAATAAGCACTTTTATTTTTGTATTTTTATTGCACTTTTAATATTACACAGTTTCTCTACCACCTTGACAACACCAGAAACATGGCTTCCTTCTGTGGAACACGCTAGAGCACCAGTCCCCAACCTTTTTGGCATCACCCACCAGTTTCGTGGAACACACCCTTTCCACACACTCGGGGCTGGGGGTGATTTTGTGATCATTCAGGCACATTACATATATTCTGCACTTTATTTCTATTATTATTAACATTGTAATATGTAATTAAATAATTATACAACTCACCATAATGTAGAATCAGTAGGAGACCTGACCTCCTTTTCCCACGACTACACAGTCCCATTCCTTGCTGCAGTGAATATCCTTGTACTTATTTTTTTACACACTTGCTCAGATAATTTTTAAGTACAAATTCCTGAGGTAAATTTAGATCCCTTGCATGCACAGTTCACAATAGGGTTTATGCTCCTATGAGAATCTAATGCCACTGCTGATCTGACAGGACACGGAGCTCAGGCAGTAATGCAAGCGATGGGCAGCACCTGTATATACACATGAAGCTTGGCTGGCTTGCCTACTGCTCACCTCTTTTTGTGCTGCGTTATCCATACCCCAGGGTTTGGGGACGCCTGCACTAGAGGACAGAGCCTGCTACACTATAGCAGTCCTCCCCTTGTGTTATGCACAGTACTGATCAGTCCCTTTTGAGCTTCTCAACCTTGTATAAAACTTTGAGACAGTTCTGGGACCATCACAAGGTTTATGAAGGGTTAGAAAACAATACACTTAAGCAACTAAGACTGTAAATCGTTGAACTTCACAGGGCGATAAAAAGAAATGGCTTCTAAGAATCCCAGTATGTATGATTTTTTATACAAACCATAAAGATGATTTCTACCAAACTCAGGACACTGTGGCGAGCTTAAAACACGAGGGTATTGAATCATACGTATGGTAATTCCTAGATTAGGTCCTTGCTGCAGTGAATATCCTTGTACTTATTTTTTTACACACTTGCTCAGATAATTTTTAAGTACCTGAGGTAGAATTTATTTGGGGGGCTTAGCCATTCCTTGCTGCAGTGAATATCCTTGTACTTATTTTTTTACACACTTGCTCAGATAATTTTTGGATGCCATGTTTTGTTTTGTTTTAATACACACCTTCAGAATCGCAGAAGATGATCCATATTTGGGAAGGCCTCAACAAGTAAGTGTCATAATCTCACTGATAACTTTATTTAAATATATTCATATTTCATATGCAAGGCAACATTAGTAAGTTAGCATTAGGTAAATGTATATTTCTAATTAGTAAATTTTTTTTTTTTTTTTTAATTTCACGTGCGTCCGAGAGTTCCCCCCAAAGATATCCGAGGGATAATATATATTATATATATATGGGGCACATATTGTTGCACAAAAATTGTATATGCTACAGGATAGCTATTGTATTAGCTTTCTAGAGCTACCATAACAGATCACCACAAACCTGATGGCTTAAAACAACAAAATACATTATTTCACAGTTCTGGGGGCTAGAAGTATCAAATCAAGGTCTTCCCAGGGTTGGTTCCTTCTCGAGGCTCTCAGGAAGAATCTGTTCCATGCCTCTCCCTAGCTTCTGGTTGGTTGCTGGGAATCCTTGGCTTGTAGCTTTATCAGCTCCAATCTCTTCCTCCATTGTCACGTGCGCTTCTTCCCGGCGTGTCTCTACTGTGTCTCTAACCTAAATCTCCTCTTTTTTTCTTCCAAAAGGCATCATTGGATTTTAGGGAGTCTATATATCCCATCCAGAGGATATATACGCAGCTGTGCCACGTCAATCCTAATATATAGTATATATATATTACACAGGTACCGGGGATTAGCAGTTAAAGGTGTCTTTTTGGGAGCGAACACAGTTTAACCCACTACAGCCCCTTGACATATTTATTTAATGTGTACACATGGATGTAGAGAGTGGAATGACAGACCATGGAGATTCAGAAAGGTGAGGGATGGGAGGGCAGTGGGATGGGGGTGGATGATAAGAAGTTACTTAATGGGTACAATCTATGTTATTTGAGTGTTGGATACCCTAAAAACCCTGTTTTCACTACTATACAATCTATGCATGTAACAAAAATTGCAGGGTTTATATATGGGTCCCCGGTGTATATACCGGCATGCCCCAAACTTTGCGAGAGTGTCCCCCCCCAAAGAGAGAAAAGATCTTTGAACTCAGAATTTGAAGATCTTTATATAAGTACTGACTACTACAGATCAGCTCCTCAGACTTGAAGAATCACTTAGTCCCCGTAATCCCTCACTTTTTCTCATTTGTAAATAGAAATGCTAGCACCACACTAACAGGGATGAGTCAAAAATATTCAATGAATGTGCTTGTAAGCATAAAACTGTTCCTATCATTATATTAGTAGTTATGAAAGCATACCAGTGTCCTTTTTTCTTTTTCTCCTATATTTTATTTTGAAAAATGTTGGAAAAAATAAATAGAAATGTTGGAATAATCTAACAAATCTACATTGGTTCTTAAAACCGACATTTTCGCTTTTCTCTTTGCTCTCTTTTTCCTGTGTGTGTGTGTGTGTATATATGTATATATGTATATGTATATACATAATCATTTCGAAGCAATTTTCAGACTCTGGAGCAATTATAATGGCAATATTAAATTATTTATGTAATGATTCCAAGAAGTATTTAAAACATGGAGATTTGTTCATTCATCAGCTATTTATTGAGGTATTACTACGTGCCAGAACATTGGCTTAGTCGGGAAAAAATAAGTGATATATACACTCTAATTTCAGGACCCTACTATTTTAATAGGAAGAACAGAGACATTGTTTTTCATATGGTGAATATGTATATCCGATAGGCCCTATGCATATATTTTCCGGGGAAAGAGACAGAGATCACTAGGTGCTACCTTGGAGGAAGAGCAGAGTTACGGAGGACTTTCCCAACCAAACTCTTCGTAACCTGTGTTTTGAAGATCTAGTTTCCTAGACTAGAAAAGGTGAAGGAACACTAGCTCCCAGGATAGCCTGGTCACATTTAAATTTTAGTGGCAATCATTTAAAATAGTGGATTTCTGAAATTACACGTGCAAAGAATCAGCCAGAATAACAGAAGTGGAATATGTTTTAAAGGCTCTGGTATCATTTCTATTAAAAAAAATAAAATGGACATATATAGCATTTATCACTTCGGGTCATATTCTGATTGATTTAGAAAGAATGACTGCATTCCTTTTCACATTAAGATGCTCCTTTCTAATTTTATTTTTAAAATGGTGATTTACGATAAATCTAGGAACATTTTCTTTTATTCCACCCAAAACATTTCACTAATTCTATTATCAAAACCGTTTGTTTTACCTTTCGCTTTTAATGTGCTTTCTCTAACAATTAAGGGCGAACTAACCAGCATGAGGATTGTGTCTGCTTGATTTTAAACCATCCTTTCCTGTCTGTACACAGGAAATCTTATCAACAAGAGATGATTCTTTATGCCACAGAAGAGTAAAACCTGCTGAAAACATTCATTTTGAAAGTTTTTCTTATGTGGGCATCTTTGCCATCATCAGTAACAGGGGTGGGGCATATTCTGACATTTCCATTTTTGAGGCAAGCCGTCTTGAAGTTTTTTTCTTTCTTGGCTTGAGCTTGGTGGTTTATATTTCCTAAAGTTTGCATGTCCTCAGTGTTTTAGTGGACTCTGGAATTTGCTCTCCACCCTGACCTAATAACAATGCAAGCTGCAGCACAACACAACTTCTCTCTTAGTAATGAAGTGAAGAGTATATCTCTCTCCTAAGGTGAGCCCTTTTGCCCACTCGCCAGTCATTTACCCACCACAGGAGAGTTTTCCTGCTAGGTTATAAACAATTTGCTCTGAGACTGTTAAAATCCTGTATCAAATGAGGCCCATTTTTGCAGAACATGGTTTTTCATTCCTGTATTTCCTTTTCAGCAACAATTGAATACCATCAGTGAGCTTTTAACTTATAAGCATTGAAGTGAACCGCATTCTTTGTTCCTCAGTTGAAAATTTCCATCCCTCAAAATCGATCTGAAGTACTGTTTATTTAAACGAGATTTTTCTTACTCTTAATTTACTAGCCATACCAGGATCTTCAGTACCCCAGGAACTTTCAATAATTTACTACTAAGGGCAGGAGACAAACTGTAATACTCGCTACTAAAAGAAACGAAAAGCTAGTTCAGCACACTTACTAGTCTCTCATAAAAAGTAAAAATATGGCTGGTTTCCATGCTGTCCACAGACATTTCAAACATATAACTTCTTTAGGCTAAAATAAATAGCAAGCTCAGAATACAGTTTTAAAGTCCTAAATGAGCCAGCGGTTACAATGTTTTTTGATAAGTAATGAATAGTAATTTATTAAGATAAAAATGTACTTCTTCAAAATATTCTGCATGCCCACTCTGTTGCTGCCCTAACACATTACCACATACTTGGGGCTTAAAACAAAACACAATTATACTTCTCAGTCAGGAGCTCAGAAATCTAGAATCAAGGTGTTGGCAGGGCTGCTTTCCTTCTTGCGGCTCTCATCTCTTTGCCTTTTGAGCTTCTAGTGGCTGCCTGCTTTCCCTGTGCACCCTCTCATCACTCCAGCCTCTTGCTTCCATTGTCATACTTCCTACTATTCAGTGTGATTTCCTGAACCCCTCTCATCACGCCCACCTGGACAATTCAGACACTCTCTTCATCTTATTATCATTACCTTAATGACATACGTAAAATTTCCTTTTGTCATATAAGGTAGCACTCACAGTTTCTCAGGATTAGGATGCAGACATGTTTAGGGGGTCCTTATTCAGCTTAACACACCCACTAAATTCCAGGTATTTTGTGTTATGCTAGGAAACTGAAGGTAAAAGTAATGAGTGAGCTCAGTGCTTAGTTGTCTACTCCTTGTACTCTCAGTTATATTTTCAGTTATTCTGTAAATAGTCCCAGAGGTGCTCTCTAGCATTCTTTCAGGCCTTGACATTGGATAGCTACATGAGCCGTATATTTACCACCATAGAGGAAATACTGATTTCTAGGATTATATTATTTTGTTTATACTTCTAAGAGAGTACAAGCTTCAAATCATTCATTCAACAACTATTTAAGTATCTGTTCTGTGAATACCATGTACTTGGCCCTGAAGATATACCAGTAAGCAAGCTACACCAGGTCCCTGCCTCTGGGGACTTTATACCCAAGTTATGCTTCTCAAATCCCTTTGTTACGTAAACGTTGTCCAACCCTATGTAAAGTTTTGTACACATGAGAACTACCTAGGTCTCATGAAGATCTTTTAAAACCCTGATTTAAAATATTTTCAGATTTTTCTTTTTGGCTTTAGTTTCATTCCTATTATTACATTTTATCCTTCTTTGACTCATACAATATTTAATCCAGAAGTATTTCAACCACAGATGGCACTGCCAACAGGTAAGAAAACTCATCCCTGTTACAGGTGTCCCAACTTCAAATTTTTTCATATAATATAGGAAAAATAATGATTGAAACATTTAAATGTTCTTCTTTACAGATGTTTCATTGGTGATTTCTTTTAAAAACCAATCTTTTAACATACTTTCTTGAATATATTTCCAAAAAATATTTCATCTCAATTACCCCTTCTATCCTCTTTACTGCATTTCATATCTGCTACGACTACTCAGAAGGAATTTCTTTAGTCAACATAACCATTTTCTTTATTATCTCTGTATTCCTTTTAAGTCCTTTCTCCCAGATTCACACGAGGCAGTCTCCACTCTTCATTTCTGTTTCAAACATTTAAGAGGGCCTGTTGTGTACTACCAGTGTGCCAGTCACTGGGGAATCAAAGTGTACAGAAATCATAAAAATCATCTCATTAGAAAAATCATCTTTATAAAAGCTTATAACTTTGCACTATGACAAGTTGGATAAAACTCATAATCCTTCCTTCTACCATGACTGTATTAATTGTGCCGATTGGCAACTGTTTAATTTCGTAAGAGTAATAAAAAAAAAACTCTCTTTCTTAAAAAAACTGATTTATTTGTATCTAAACTTGGTGTCATGCCTCTTTTTATGTTCTGTTTCTCTCCTCACTTCACCCGTCACCAGTGGCACTTAACACATGTTCACCAGTGTGAGTGAATTATGCAAACTTATCTGTAAACAGAGTTTGCTAAAAATCGCTGAAGGAGGCATCACCTCTTTTATTTACCAGGGACTTCCTTCTCTTCATTCCGGGACTTTATCCCATTTGTATTATTCTCATTTAAAATTATCATCCTTACTACAGTACTTACTTTTCTTTTCTTTTAGATCAGAAAACTTTTTCTGCATTTATATCTTTAGTATTTCTAGGAGTTCATGGGACCCAAAAAAGTACATCTACTATACTTTCACCTTCACTAGTAAGGTGTATTTCAGACGTTTTTCTGTCTTTACCCCTACTAAAACATTATTTTTACGCTGCCATGTCTGAGATCTTCTGAGTGCTGTCCAATTTCAGCTCTAGGTCAGCTTCCTGTGAGCAAGTTAAATGTGTTGGTACTGTGTGTGTTTCTTCGGAACTTTTTAAATTCTCGAGTTCAGTATTTTTCTTAGTATTAATGTATTACTCGAAATATTAAGAACTTGGTTCTGTCCACAGGAAATACACACATTTTCACTTAATGTCTTGTGAATACAAAACAGTATCCTGAGGCAGACGTTTTCTTAATTTTATTCCTTCGGATTTATGGGCATCAAATAAGATTATCAAGATAACCATCTCAGTAAAATATTCTGTGGTCACAGCTTTATCTTGTAGAAATTATTTTCCCATAATATTACAAAAACTATTCAAATTACACCTAAGAATCTAATTTGTTAGTTGTTGTTACACCATCATTTTTACCTGTATGTTTTTCCCTCTTCATTCCAGTGTCATAGTACAATTTTTATAGTCCAAAGATATATAGGATGTTGTATTCAAATTTTTAAGAGGTAGAGAGGTTGATTATCTAAACCAATATTAACTTGTAACTCTAAAATGGATTATTTTAGTCTTCTAGATTTTTTGAAATCTAAAACCTTTAGTAGATCTAGTACTTCTTCAAGACTATGGGATGCGACATAACTCTTACTCTAAAGTTAAAATTTCTCTCCACACTCGAATGTCCTTTTCATGGCACAGAAATGTGGCCAAAAGAATGTTGGCCTTAAAACAACAAATACATGCATACAAATCTAATTTTCTAGTTGGATTTAACTTTAATGTGTTGCCTGAAAGAGGAAAAATGGCTCTATTTTACATGAATTTTCACATATTTAAAGGAAATTAAATCCTACAGGAAAAATAATACCAAATTTCCAGTTGTTTTTAGCAGAGTTAATAAGTGAGACACTTCAACTTTAAATCTAAAACATGCTTCCCAACTCCTCTCTATTTTTCATGACATCCAAATATTGCTCTGTTAGAGGACTGTCTTGATATGTTCTTTCACCATTTTAACACGGAATGTTTTTATAAGTGTTACATTGTCATACAGGCTGTATCTTAGTGTCAAAATATTTCTAATTTCTATCAAAATTTTATTTCCATATCCAATTAAATTCTAGCCATTTGGTGGGGGAATTTTTAAATTATGATTATGTTTCTAAAAGTAATTTAAAATGTCCAGGGGTGAATTTCATACAGACAAAAGATGGTAATTTAATACATTGACCAGTGACTCCCCCTTTTTTTTCTTGTGTATGCTTCATTTCAGATGCATTCATTTTTCAAACTCGCTTCCTTGTAATTTCTTGAATAATACAGGAAGTAATTATACCCTTGTTTTCTCCAGTTCTCTAGCCTTATCCTGATTTATCATAATATTGAAGATTAAAAAAATAAATTCTCTCGCCGCGTGAGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGCCAGGTAGATCACGAGCTCAGGAGTTCAAGACCACCCTGGCCAAGATGGTGAAACCCCGTCTCTACTAAAATACAAAAAAATTAGCTGGGCATGGTGGTAGGCCCACTGTAATTCCAGCTCCTCTGCAGGCTGACGCAGAGAATTCCTTGAAACCAGGAAGCAGAGATTGTGGTGACCCGACATTGTGCCATGGCACTCCAGCCTGGGTGACAGAGTGAGACTCTGTCTCAATAAAAAAAAATTTTGACAAAAAAAAAATTCTCTTTTGTGTTATAGTTTATTTTTAATTTCAACCTGAAGGTTTATCTCCTTACAAATTTATTTAAAATAGAGGTCTTGAGCTTCTTTCTGAGAAAAAGAAATGAAGATTAATGGACATACAAGCATTCTCCTAAAATATTTTTAGCACCAAACATCTTAATTTACATTCAAATAAATGAGAACCACCATATGCCTTTATTTATTGCAAAGCTATGGATTATTGTACTATTCACATAAAAATCACCTGGGAAGCTTAAGGACTTTTTCATATTGAACAGTTTGTACTTATGTTGTCAGAGATTCTGATTTTCCTTTGAATTTTCAAGTCAGATACCATTAGGGTATGGATTAAAGCCTCTAGTTTTCTTTGCGTTTTTACAATAACTATTTGCATGTACCTATCTTCAATTAAATTATTTTCAGTATTTTATAAATGCCTGAGATGTTTTAGAAACACACTTTATATGATAGCACAATATTCAAAATTGCTTATAAACATCAAAAGTTATGGATTAATATGAAAATTTTACCATGTCTGATAGACCAGATTACATTGGGAGTGTCGGGGAGGAGAGATAGCCTGAGATCATTATCTGTCTATCAGACGTATACATACAGGTTGCTAGATCAGTATCTTTTAATTTCACATTAAGCAACTCAGAGATAGCCTGAGATCATTATCTGTCTATCAGACGTATACATACACGTTGCTAGATCAGTATCTTTTAATTTCACATTAAGCACACTCTCTTTGAGGAAGGAAAGTCAGTGTCTAATGATGTGAAGGCCAACCATGTCATACTACAACCAGAAAGTGCTTGCTCCTTTTAATTGCTATTTGTCATTTTAAAATGCTTTGTTAGGAGACAAGATTATGAAGGCTGTTGACATCAATTCTTGCCGGCCATATGCCTTTTATTGGGTTAGGAAATGTGCCATCACCTTTCAACAACATATATAAACTTATTGTGGTTCGCTAAAAAATCAGTCTATTGTTAATAAGGGTTAATTTAATATTTCAGACAAGGAAGAGAAATTATATCCTTGTGGAATTTTAACCAAAAATTGATTTGAAATTTCTACATAAAAACATAATTTCAGTTTTTTACTTGCTTTACGTTTTATACCAAATTTGAGAAGCCTCACAGTTTCTTTTGGTTTCTGTTTGTTGTTTTTGTTTTTAGCAGATGGCCGGAAATGTGCCATCACCTTTCAACAAACATTTACTTATTGTGGTTCGCTAAACTCGTAAACTATTGTTAAAATAAGGGTTAAATTTAATATTTCAGACAAGGAAGAGAAATTATATCCTTGTGGAATTTTAACCAAAAATTGATTTGAAATTTCTACATAAAAACATAATTTCAGTTTTCATTCACTTTACATTTCTCTTACTCATTGTTCACACTGTCCTGAGCCTCAGTATGTAGTTCTGTAACTGCAGTTCCAATTACAGTATTAGAATTACAGTTAATTACAGTATTCTGCTGTCTCTACCAGCTTAACTTACCACCCACTCCCAGGAAGCCAGAGCTCAATTTCCATTCATTTTCATTTATAACGAAATACGTATGCATACAGTTCACATGCACTGACCGATATCCATCTATTATCCTTGCACATGTAGTACCTCTTAGCCATACCTTCAAATATTAGAGCAACCTAAACAGGTAAGATTAAAGGGGTGGGACTTTAAATGTTAGATTCCAGTGTCTAATATTGAGATCATGTTAGAATGAACTATTCAATTCTCTTCCCTCTCGTGTCAGCCTCTTTGGAGTCAGCAGAGGAACATTTTTTCAGGTGCTTCCCCTTACCACTAGAGTCTGTAGACAATAGCTCAGAACTGAATGGCCTCCTCACTCTATCCAACTCTCTGGATATTTATAAAACAATTGGATGCCACCCCACAGAATGAGCACAGTCAGTAAATCTTTGGATGGATAAACTAATCACATTTGTGTGTGACTGAGGATATGGATACCTGTCCTCTTGCAGCTGTATTACCCAATACATTTTCTAAGTATTCTTTTCATTAGCTCAGGTGAGTGAAACACTTTTGCATTTTGTAACATTTAACACATGCTAACTACCTCACAAGCTTAAATAAAGCATCCACTGCGTTGTGGTTTCCAGAATCGTGACATTATATATGTGTTATATTTCGTCAGCATTTGATATAAATGTCTTAATGATTGCTGAACAGGCTATCCTTATAAGGTTGAAATTAGATGAAAGTTTTTGCTGTGGGGGCAAGAATAGCCACATGAAACTTTGGGGCATCGTTCTACTTCTTGCAGGTGTCACATCCTGACTCCTCAGGTTGCCAGTGAACCTCCATTGCTCTACCTCCATGTTCAACTCTTTTTAAGCAGTTATTTCTCAGAGAAGGTCATCAATTCCCAGTGAAATTTTATCCCTTAAAGTTCTGTGGCTCTGGCATCCTGGAAAATTTCCCAGCTTTTAAGATCTAGGTAGTCTATGAAACAGAAATCAACTGAAATTTGTCTGCATATGCCAAAGTATTTTTTCCAATATCATTTTCATAAGCATAGCACTACAATAAGAATTTTTAAATGTAATTCCTTATTATGGATCCAACAGTTATAAGGAAAAATTGGCATTTATGATTTACCTGAAGGGTTAATGTAGTTCCAAAATTCAAAATTTAATTCATATAAAAGCTTATGTGAGTAAAACAATGTGTTTACCAAAGTGATGCTATTTTCATATCTCAAATTCAGTGAGTAAGAAGGTTGTATTC1AAGTCAGACTTTCTGACTGAATGGATGTAGCCTTGCCTTTGAGGTTGATGACTCATTTTAAGCAAATGGAGTTACTGAGATGAGTGAATGTGGATTAAAGGCAAAATTTTGAATCTCAGAATTTAGAATCAGAAATGCATCCAGACAATGCATTTGACCACATCTTCCTGAACAGTTCTATTTTCATCCTCAGATTAAAATTTAACTTCTGAGGATTTAGATACTCGTATGTAACCATGAAATATCTATTAAGTATTGTCTATTTGACACCACTCCCAATAAAGAGATATAACACATACGTGTCTATATTTTTCCAACTGTCCCAAACCAATTTTGTGATTAAAGATAATGAATTGTGTGTGTGTGGTTTTCGCGTTTTTTTTGTTTTTTTTTTTTAAGTTAGAAAAAGATTCTTTTTTCTTTGGGACCTCTTAGCCACAGATTTTCCCCAGCTCTGACGGAGATGAGTCATAGCAAGACTACTAATTTTTAGAACATCCAGTTCTGTTGCATATTAATCAGTGTTAATTAACTAATACTGTTTTTTTTCATGGTTTTTAGAAATGGTCTCACTGTGATGAGTTGATCATAAACTTTAGACATTTGTGTGCATTAAGGAAATTTCCCAGACCGGGGAATTTACTTTATGCCTTATTCATTTAATTATTTAAAAAAACCAACAGTGTTTGCTTACAAGGCATACGACTCAACTTCTAAAATTATTTTTAATATCAAATTGTGTGAGAACCAAAACAAAGGAATACCTCTCACTTCATCTCCAGGCTTCCCTTGTCTTTAGATCTGGTTAAAAATCTCCCAAGGAATTGTTTTAGGTCTCACTCTGATGAGTTGATCATAAAACTTTAGACATTTGTGTGCATTAAGGAATTTCCCAGACCGGGGAATTTACTTTATCCCTTACTTATCTGGTAAATGTGTTGAGGACTGATCTTTGGAAATCAGGAAGTTTTTGGATAATATAGGAACAGTTCCAGATGCCTTCCCAGAGATTTAAATCAGTTCAAGGCACCTGGACTGCTCAGAGACTGCAAGACCCTACTTGGCATAATGAAATGTAGTATAGTCTAAGTAGTGCATACGTTTTACATTTGTTCATGAGCTCAAAGCTCTCAAAATCTCCATGTTTGCTGGCGTTCCACAATTTAATCAGTAAGCCAGTGAACCCCCACCAGCAGCTACTCGCTGTGATGAGCTCATGGGCACATGATCTAGTGCTGTATATGCAGAGTTGCTCCCACATAGAAACTAAAAGGTGAGAATGTTCCTTAAAAAATCTTAACGTATTTTCTTTTCACCAAAAAGTGAATCTCTAAAACAAAATCATCTGCTTTACCGAACTATGTGGTTATAAACTACTAACACTACCACAAATTGATTGACATCATTATAAAGTTGAATCAGGAAATACAGCGAAACCTCCCTTAATATGATGATGACCTCATAATTATCCTTGTTTTATTCTTTGTATACATATCAATAACTTACCTTTATAAATCATAAAAAGTTAGAAATCTGGACTAGACCTTAAAGATGGTCTGGTATAATCTTCCCTTTTGTACAAATCAAAAAATATCACACTTCTTAGGTGTTTATCAGCCCACAGTAGTTTATATAGTGAAGGCTTCCAGCTAACTTCATTAATTAACTATATCTATAAAATTTCTGGGTTAGATAGTATTTAAGGGAACTACCTAGTTTTTGAATCATTCTGGTAGGTTAATATTCAATCTTGAGCTTGACCATATTAATAATCATAAAACAAAAATCTTATCCTCTGAAAATGCTGAGACAAGCTTAACAGATGCACGGTCTAGCACAGCGTCTGTTCTACAACGCTGAAACAGTATATCTAAATAAACATCTCTGTAGTCCCTGCTGAACCAGTTGAGGAAGGAAAGTCAGTGTCTAATGATGTGAAGGCCAACCATGTCATACTACAACCAGAAAGTGCTTGCTCCTTTTAATTTAGGCAGCAGCAATTTAAGACAAGGAAGCTTAAGACAAGGAAGCTCTGACTAGAACAAGCCGTAACATGTTAAGTCTAAAGCCTAAACTCTCCACACATCCATAGCATGAGAGGTTCCATGGGCTTAGGTACCTGGCTTTTTAGCCATATCTTAGTGTACAATATCGATTAAATACCATTTTTCGTTTTGGGACCCAGTATATAGTGTTATATAGTGTGTTATATCCCTTGGGGCCCAAAAAAAAAAAAAAAGTGTGTGTGGGGGGTTTGATTTAAAAATTTGTATGTACCTTTGTTGCCCTAATTTTTAATAAGTATTTCTCAAATTAATTGCCTTAAACGTTCACCTTTGCAGAGAGGATTTCGTTTCCGTTATGTATGTGAAGGCCCATCCCATGGTGGACTCCTGGTGCCTCTATGTTTTTCTTCTCTCATTTAGTAGACATAGGTCAAAGTAAGTTTGTGGTAGCTCTCCTTCTATTTGAATTCTGGAAATTTTGATTTCCTACGATTTCCAAGGAATTGCTTTAAATGAGTACGGGTTCCCTTCGCTCCTAAGCTGAAGTGTTCACATGATTATTAATTTTTATAGAAGAATTTCTCTCCTACCAAATACAAACTGACAGATACTAAAACTTTGTTAACATTTCAATTTACTACAATGTCTTCAGCATTACCTAAACAAACTTACTATTTCTTGATCATCTTAAATATTTTTAAAAATTGGATACTTCCTGAACTTTAGTAAGTCTTTGAAAAGAAAATGGTTGATTTTGACTCTTTGGAGATTTAGTGAAAACCAAACAAGTGACTGAGTGTATGGATTATATACTATATTATTTAGATTATGAATTTCGATCCAGACTTTGTTATTAGCTGTGTAAGCTTTCAATAGGTTTAACCAATACTTCTAAACTTCACTCTCTTAATGTATAAAATACAAAAATATAAATAGTATATACTTCATAAGGTCCTTTAGAGATTAAATGACAAAATGTGTACATGTTCCATAGAGAGCCTGAAAGTACCCTAGGGCCTTGGCCTGAGCAGATGTGTGGCCCTCTTGGAATGAACTGCTGTGTATATAGTGCCGCCCCGGTATATAAAAAGGTTTTTCCCCGGTTTAAGATTATATCAGAGAGAGATCCCCGTATATATAGTTAATATGAGACTTTTAATTTCATAATATGCTATGTTTCATAGACTGACTGATGATAAAACATAGACTCATAATCATTTACCACATAACGCAGTCAACAATTGTAATTTAGTTTTTTATAAAAGTTATTATTTAGTCAGTAATTCAAGGCTTGGACAAATTAGTTCTCACTATGTCTGTGTGCCCCTCAGGGTGTAACATACTTTTCGACTCAGTCTTTTTATTGGTTTGTTTTTGTTAAAGTACATGACTCACTACAGCAGGCCCTCAGCAAAGTTGTGATGTAAAGAAATCTGGCCGGGCTCGTTGACTCATCTCTGTAATCCCAGCACTTTGGGAGGCCGAGGCTAGCAGATCACAAGGTCAGGAGTTCGAGACCAGCCTGGCCAATATGGTGAAACCCCATCTCTACTTAAATACAAAAATTAAGCTGGGTGTGGTGGTGTACACCTGTAGTCCCAGCTAGTCAGGAGGCTGAGGCACAGAATCGCTTGAACCTGGGAAGCGGAGGTTGCAGTAGACCCGAGACTGTGCCACTGGACTCCATCCTCGACAACAGAGCGAGACTCTGTCTCAGGGGGAGAGAAAGAGACCCTATATACCCGGGCCCCCCCCCCCCCTAAAGCCTTGCATTTTGTTTCTTCCTTTTCCTCTTATCCATCTTCTAGGCCCAGGCCTGTTAAATTTCTTATCCTTATTCCCAAACAAAGAGCAAAATGTTCTGACGTCCTTCTTTACCTTTCAAGTGAAACTCACCCATTATTTAGTATGGGTACTACTAGTCATAGTTGCATTTTAAGTCTCTTAGCTCCAATTGTGGAATGAAAGATGTTTTTTCTATTAAAAGGTAATTAGGCGGGTATATGATGGCTTAAGTCCACAGAAAGCAGACACGGTCTTATGGCCTCACATCCTTTAGAACCTTGATGAGGAATGAGGAGCAGCAATTCCCCTTATATATACCCGCAGTGAGAGTCAAAAGACTTGCCAACTGGTTTGTATAACATTATCTCTTTTAATCTCTTACAAATCTCAGTAGGTAAAGTGCAATCCCTGTGAACCCCAAAACAGACTCAGAGAATGGAATTATAATAACTGGCCTTTCTCACAAGACTAGTGGCTCTATATCCTGCAGCAGGCTATTGCTCACCGAACCTTCAGAGTATATATATGTTTTGGGGTTTGGGGGGCAGGGTTGGGGCCTTTAAATCAGGTATTTGGGAAAAGGGAGAGATCTTATATACTAATGATAACTCTTGAAAACAACGGAGAGAGAGGCTCACTGGTCAATGGGTACTCAGGTATTGGGGTAAGCCGGCCCACCACTTACCTTTTTAACACATGTGTCTGTGTGTCACATGTATAAATATTGTGCCTTTATGTATGTGTATATTTGTGAGAAGGGGATTGAAAGACACATGTTATCAGCATTGACACTGACTATAATGACTGAACAATTAACTTTAAAGCGAAAAAAACTGGGAGTTTTTTCTATACCTTCCCACAAAAATATAAATTATGGTATTTTGTTTACTTCTATTGCTCTAGTATTTTGTGACTAAGTAACAATTCTTGATACTAACAAACACATGGCATTAACCTTCTTATAAATTTATTGGCTAAGAAAAAACTTTATACATCCATTTATTCCCAGTCTTCATACATCTTTCTCATGTAGAGGTTTCATCTACTCAAAAACATATTGCTGCCTCAGTCACAAAATAATTTACAAATGAAACAACTTAGTGGGCATTAGATGTTCTTGTAGAATGAAAGTTTCTATATCAAGGACTTTAGTACTTACTGGGAAATATACATATGTAAACGACTAATAATAAAGCAGGTTCAACTACAGTCACATTATTTCACCAAATCATTTATTTTTTATTCACTAATTCAGTATCCATTTATTAAGCATTTATCAACTTGTAAAGACCACCACCAACTTAGAGGTTACAGAATATGACTATACAACCTGTCATTGTTCCCTTAGCTTGTCATTGTTCACTCAAAATTGAAATGCTTCTGCTGTTCCTAACACTTATACGAAGTAATTTTATTTATCCAAGAAATTCTTAATTGCAAGGATGGCTAGGAGAGAAAGAAAGAGACAACGCCCACGTATTTTTTTTTTCCGAGCTCTTCTCCAAATATCCCTTTTAATAGTTATTTCTGCTCAGGATGACCTTTAAGTTTACAAAGGAATTTTAAATCCCCTCTTCCCTCTAATGTTTAAGCAGAGGAAAAAATTGTTCTCCATGCATCTTTCTAATCAGGAAGACCTTTAAAATTGTGCATGTCTTTTCTGTGGTACTTTACTAAGCACCTGCTCGGCGAGAGACTGTAAGGGAAACAGTGGGATAGATACATCTAAAGTTTCTCAAACTTGGCATTATTGACATTTGGGGCTTGAAAATTCTGTGTTGTGGGACGCTGTCTGACACGTTATAAAATATTTAGCAGCCTCCCTGACCTTGACTCACTAGATGCTAATAGGATTCCTATAATTGTGACATCCAAAAAGTCTCCACATTGACAAATGTCCCCTGGGGGGCAAAATCACCCCTCTTTGAGAACCACTGATGTGGATGCAACAAAGAATCAACCTTAACCTTACCCATTTGCATACTTTTCTACTATAAGTTGTCTCACATAAATTACCTACAAATTTCCAAGTGTATTATTTTATAAACGTGCCTTTCTTGGTTATTAGTAGATATTTCTTATTTCAAGATGGTGATCATGGTGTCTGTATAATTTTCTGTTAGAATATCAGAGTTAGTGTACCTGGATACTAAGGAGAAAGATAGAAAAGATAAAATATGTATCTTCAACATTTTGTATTCTGTGATGACCCTAAAAGCTAATGTGGGAGTTCTATTGACTGTTATGAAATGCCATGGGCTGTGCTTTTCCTCAGCTACAGCCTCTCTCCCTTGTGTGAACAATGGGAGGGTCTATGGAATGATGCTTTCAGGTGGGCAGAGGCCTCGTGGAGGGTGGCCCCACACTCACCCCCAGAATCCAGAAGCATTCCCACAGGAACTTCAGAGGGAGAGCATTTACATTTACAGGAAAGAAATGATATCTTCTGAGCCTACATTTGCCACATATTCATTAAGTGCATTTCTTCAGGCATTACACTAAAATGCCATGGGCTGTGCTTTTCCTCAGCTACAGCCTCTCTCCCTCCCACCTCACACCCTCTCTTCCTGTCATGCCTTTGTGAGAGCCCCACCACTCTGCCCTGCCTGGACAGGAACCTGGAAACCCTGATACTTCACTGCATACTCCGTCATATGGAGACAGCAGGAAAGAGTCAGGGGCCAACTTGAAAAGATTTGGGGCCTGGCTGTGGTTTGCAGCCTCTAGACACCAACTATACTTTATAGAACATGTCAAAATATAGCCTGTATGGGTTACTCTTTACTGATTGTCTAGATTTGATGCCTTACATTAATCATTTAAAAAAACCAACTCTAGAAGTCTACTCAAATCCTGCATTTTCTAGTGGATAGTGTCCCATGCATAAAACCCTGTTTCGCATAGAGTGTAGGCTAGCTTACAAGACCCTCTTACCATGTTGAGATTATTTCTAGAACTCGGCTACTGAACCATCTGGTGCTCTGCCTGTCTCTTTCACATACCTAAGAAGAAAATTTCCATTTAGCTTTCTGATATCTTGCTGTGCAAGTCTTCATGCTGCCCCCCCAAAAAAATTTTAATTATAAAATTCTTTCAAGCATATAGAAAGTTTAATTGACATAACAGACACTATGTACTACAACACAAATTATTTAATAGCTATTAGCATCTTACCTTATTTGCTTTGATAGCTCTCTCTCTCTCTCTGTCCTCTCTCTCTCAAATAAAATAGTTACAGCTAAAACCCCACTTATCCATCATTTCTGGTTTGCCTCCTTCCTTCTCTTACGTAAGCTGCTACTCTGAACTTTCACTCCCCAAGATCTTTTTATATTTTTACTACATAAAGATGCATCTATAAATACTCGCATTTTCAAGAAAGTTAATTTTTACTAACTTCAACCCAAATTTGCCATTGTATAGGATGGCTCCTTTTCGGGCAAAACATAGGTTCAAACTGGACCCCATTGAAGATTAACTGGTACTCACTTTGATCCTATTGATTCCTCTTTCCTGTCTAGATAGAGATCTATTTCTCACAATGTAGTTTGTACTAACTCTTATAGCAAAAAATAATATTCAGAGAAAAATCTAGGGGAAGTAAGTATGCAGACTAACTCTTATATCTTGTCCTTTCATAACAAA7kATTTCCCATCATTAAACATTTAATAATCTATTATACTGCCTATAAAATTTCCCTTTAACTTTTTTCCATTCTAATTTCATCACGGAGCTCCTAATAGGAGAGGCTGGCAAAAAACACAGAAAACCTTCCTCTAGGCCAACCTTGTCCCTGCCTGCTTTTGACTCAGCAAGGACTGCCAGCCAACGCTCACTTCCCTATTTTTCCCGAAAGCCACGCGTCAACTTTTAAAAATCAAACTGTGTTCCCTTTCACACAGGTCGCTGACAAGAGAACCACCCCCATCCCACTTCAGAAACTCTCACCAATCCTCCTCTAGAGTGACCAGACAATACCCCTTCCTATCCTAACTAATGTGACACGTCCTTCTGTGTGGTCCACTCTATGCAAAACCAGAAATTGACAACAATGACTTTCATTGTAAAGTACAAATAGCTTACCAGTTAGTATTCTTAGTTTCTCTTTACTTATAAATATCAAATCCAACGCACTTGACCCACCTCATAGAAAAGTCTAACTATTTTTAATCAAACATTTTCTGAAAGCTCCTTCTCACATATGTTGTCTTTCCTGAGTGTTTTATGTTGAGTGGAAGACGTGTTGAAATGTTTAGGTCAACAACAGCTTTTTTGTTGTCCCCTTCCACTACTGATTTAAAAAAAAAAAAAAAAGGCTCCACTCTTCCTGCCTTTCCTTAAAATCCTAAATGTTAAGTTTCTGTCGAGGTCGAATAGAGACTACCCGATCTGCTGTCGCATTTGAGCCATCACATATCCTTCAACATAATCTCCCTTTCCTTTGTATAGACTTGTCTGATTCACGTGGTTTGGATCTATTTGGAATACTAATTTAAAATAATTTAACCTGACTCAATTACTTAAAACAACACGCGAGAAAATCACCAATAATCAGCTATGTGTGCGTATAGAACCTAGTTCATATCATTTATTAGGATTTCCATTGAACCCCTAAGCTGTTCACTGCGCAACTATTTAATTACGCAAAATAACCATACCCCTATGTACATTATACTGTGTGTTTTGTAAACCATGAGAAAAGCTGCTTATTGAACAGAAGGGCTTTGTAACCTGGGGTCTATGGATCCCTGTTGGTGGTTTCAGACCCTTTTTAGATTCCTAAATTTATATGCACACTTACACATGTATGTATGTGCATTTTTTCTTGGGAGATGAGTATAACTTTTTATCATATTTTCAAAGGCAAAGATTTAACATGGTTAAGAATCATGCTATAGCTTGTATCACTTTAGCTTTTTCATACCAGCTATCTTTTTAAATGATCTATGTATAGTTTTTTAAGATTTTTTCTTTTTTTATTCTTGCATTTTTAATCAATTTTAAATGAAGTGAAATGCTTTATGTTGCTCAACACATAGCCCAAAAAGCCTCCCTTCAGTTTTCCAGTACCTCGAAAAAACATCAAACTCAATTGATCGCCAAAAGAGTTGAATGGGCTTCACTGCTTTTTCTTTCTTGCTCTTCCATACATTTGCAGATTAAGCATGAAGCTCACCATTAGTGATTGAAGCCAAAAGAGAGAAGGCAATTCATTGAACAAATATTGATTCAGCACTGTGTCTCACGTACTGCTCTAGACAAGCAGACAAAAdTCCCTCCCATATGTAACCACAATTGAGACTTATAGGTAATTTTTGTTGCAAGTAGTTCAGAAGTTTTGTATTTTGTCCTAAAACAAAATATTACTTTGTAAAATATTTTTTTAAATAGCCCTCTAAATCCGCTGTATATATTCAAAGTCACTATTATAAAGTGGAGAAAGCTACTCATTAGACAAAACCTATCACACAGATAATAGCTGGGAAGCTTAACCCTTAGAAATTATTAGGAGAGATATACACTCCTTGAATTTAAGAACTGTCTGAATTTTAAATTTTGTTTTCTCACTTCTGGCTTGGTGACCTTCCTCTATTGGCCATTCCCATTTTTCTGCCCTCCACTCTTCCTTGACACATGATTATTTCTGGGACCACTGTTCAATCCGAAACAAATCTCTGGTGGCTTCTTTTAAACCCAGTGCTCTCAGTCTGAAGGTATAGTGGGGCAACTCTCGGCATTCCATTCTCGAGTCTTGACCTCATAAAGTCACATATTGGCAATTCGCCTTGATAAGGTCAAGTGAACACACAGAAGCACTAAGATCCCCACATGTGTTCCACTGCCTCCTCCACACACAACTTGTTTTTCAACCCATCTGCAGGTCCAGAGGTGAAGCTGGAGCCTACCCTGCAGTCTCAGTCTTTTCTCCCCACCCTCCAGATGGATTCCAAATAAGAAGCCTCCAGACTACCTTCACCTCCCTGGGGTCTCATGGACATGGGCTGCAAAGTCCTTGCAGACTTTCACAGACAATGCTTTTTGCCTTTAGGTCCCCTTCTACCCAACAGAATGATTATAATAATGGCTTGATGTGCTTACTTACATCATCTCATTTAATCATCACAGTAATCCACTGATGCAGGTTCTGTGATCCGCATTTTATAAATGAGGAAATTGAAGCCTAGAGATTAAGAAAAGCTTAACTTGGGTCTCACAGGCTTTTAGAGATGGAGCCCAAGATTTCAGTTCATGCCATATGGTTTAAGGGCCTGCACTCTTAACCATCGTCGAATACCATTCATTATCATAATGTTAACGATCTGTTTCTACTTTGCAGGAATCTTTTAAATCTATGGTTCACAATCATGGGTGGGCTTCAGAATCGTCCAAAAATGTTTCAACCACAGAGACGCCTGGGAACCACTGCACAATTCCTAAATCACAGTGCATCATCTAGCCAATCTTGGATTCTACAATATTCTATGACAGTTTCTAAGATACATGCCATTATATAATGGCAACATATTACAACAGATAATTGAATAGATATATTCAATGTATACCGTGGAATAGAATATTATGCCACTCTGTTTTAAAAAGATAATTAAGAGGATACGGCACAACGTGGAAAACTGCTTATAACATAATATTAAGGATAAACCTCAGCTGGGCATAGTGGCTCACGCCTATAATCCCAACACTTTTGGGAGGCCAAGGCAGGAGGATTGCTTGACCCCACGATTTTGAGGCCAGCATGGGCAACATAGTGAGACCCTGTCTCTATAAAAAAAATTTTTTAAAGAAAAAAACACAGATTTCAAATTATTGCTAATATTTGTAGTGATTACAAATATTAGCTTCTTTTTATAAACCCTCCGTGGAAGCATATAGATGTATCTTTAGCTTTATTTATTCATCCATGACTTAAAGAAGATTGGTTAACACCTGACTCCACCTTGACTAGCAGAACATTGGACTGAACGAAAAAAAAAAATGTGAAGCTGTCTTACTTAGCTACAGTTTCCAGCATGTTTTCTCAGGAGCTCTATGGGAGACAGTGCAGTGTGGCTCTCAAACCTTACTACCCATAAAAATCTGCTTCAAAACCTACTTAAAATATCGATTTTATTCCATTTCCAAACCCTCCTAGAGTAGGTAATTCTCCCACTACAATACACTTAGTAACACTACAAAAAAAATATAACATTTTCTTTAATGCATAGCTGAGTTTATTAGAAAGTATCAAAACTACTGGGGCGCCGTAAGACAAAAGAAAACTTTGCCAAAACACAATAGGATATGGGTGGACTTTGGGGCCACAGCTGCCCTGGAAATATTTGCTGACCTAGATAATCAAGAAGCTTGGTTTTTAACAGCTTCCTAGAGACAAAAGATAAGGCCTTGGGCCTTTCCAATCTGAGGAATTCAAACTCCAATCACCCACTTAATTCAGGACTCTCTCAGGGCTATAGTTTCTGTTCATGGGTGATCCTCAGGCAGAGAGGTGATGAGGAAGTTGCCTGTCTCAGCCTAGGGGGAATCAGAAGATAAAATGCCTCTCTTGAGAATCAATAACTACAAGCCCAATTCTTACAGATTCAGAGTTAAGTGTATGCTCCCTGAATAGAGTAGGAAACCCCAAGTCTAGAAATGAATATGAAGTTGTTCCACATTGGGGATACCCTCAGAGCCTTGCAGAAAAGCATAAAAATGTATCTGGCTCAAAGAATCATCACCTCCTGATCAAAAATTAGAAAATATGTATGCAAATAAGCCACTCTCTTTAAGAACTGGCAGAACAATGAAAAGCAGAATTAAATCCTCAGAATCTTCAGATAATTGAATTACCAATTGTTTGATATATAAATACAAAATAAGTTTCGAATAGAAAACAGACCAGGCACAATGAAAATAAAACCAAGTCGAATTTTTAAAATTAAATGTGCGACACTGAAAATGATTCAACATAGTTAACATGGATAATTTGAAACAAAAATTATGAGCTGGCAGGTACAAAAGAAGGAGTAACAGGTCTCTACTTGAAGTCCTAGAGAAGTATTACAACTGCAGATTTCTCGCTCTACATTTACAGTTTCTAGGTCTGGGGTGAGGTTTAGGTGGTTGTGGACCACACTTTTAGGTTTTAAAGCATTGGCTCTGAAGTCATTTGGTTCAGGCCTGGCCATGATGTTGCTTCCTAGTTTTGCGACTTGCAGTGTTACTTAACTTGGCTAAGCATCAGCTTCCTTATCTATGAAACTGAAAAAATAATACCTATGTCATAGGATATATGTGTAAATCAAGTTATTCAGTACATCCCACACAGTAAGCACTTAAAAATGACAGTTGCTTCTATTTTTATATAACCAAATACACTACTACAAATATTGAGTGGCAGCTTTGCTGGTTCATTTATGGATTCATGGAGCTACACAAAACCTTCACCAGTCTATTAATTTATTTTTAGTACAGTCTCTCTAATCAGTATTGCTTCCACTGTATATTGACCCCATATCCTTTCTTCTGTCTGGGGTTAAGATAGGAGACTGAGATCAGCTGTGTCAAAAGCTTTCTTTTAGATGTAACACATGATTTCTTATGAAAATCTCATACGTAGGATACCAGAAAGGAATTTATTAAATTCTTGTTAGGCTCCTTAGTTGTATTAGTTTTGTAGGGCAGTGTTTTAATTTAGGATACTTATCATAGAGAGCACCCCTTCCATAATCAGCAGAAACACAAGATGGAAATAAAGATTTTATTACTTAGTGGTCCTGGCGACCACACAGCACTCCAGGGAAGGCCACACACCAAGATCAGGGAGCATGTGGAGAAAGAGAGAGAAAGGAACTCACGGGCCATTGCCTTTACTGGCTCCACGACATTATCCAAACAGGTTTCCCACAGGGAGTTTTAATACGTGGGTTTCAAGCAAGCAGGTATGAGTTCCAGGAGGTCACAGTGTGATGAAGAAGAAGTCACTGTGGCATATCTGCACAGTCCATGCGAGGTGTGAGCATCAGTGAAGACCAGTCAGGTAGGCTATATGTAGCTGGCCCATCGGGAGGCGATCACCAGGTGGCAATTGTATAATGCAGATATCTACATTGGCCACATAGAGGAACCGGGAGGAGGTCTACTACTGGAAACTGCGTCGACGGTCACTGAGCCCTGCTTTAGGTATGAGAAAGTCCAGCTTATATTCAGAATGGATGCAAAGGCAGCATAAAATTAAAAGCATTCACTGCCAGCTGCCATAACAGTTACCACAAACTAGGTCGTTTAAAGCAACCGAAATATTATTCTTTCACAGTTCTGGATGCTAGAAGTCCAATATCATGGTCTTCGCAGGGCCGTGCCCCCTTTGAAGGCTCTAGGCAATAATCCTTCCTTCCCTGTTTCTAGCTTCTTGTGGTTGCTGACAATTCATGGCACTTTGTGACTTGCAGCTGCATCATTCCAATTTCTGTCTCCATCTTCACATGAATACTGTCTTCTCTCTGTGTCCCTGTGTCCAATCTCCCTCTTCTTTCTCTTAGAGACCTGTCATTGTCATTTACGGCATCCATAACCCTATGTCACCTCATCTTAACTAATCATAATTGCAACGACCCCATTTCCAGATAATACAATATTCTGAGGCTCTGGGTAGATGTGAATTCTGGGGGTACACCATTCAGCCCACTACAACATATTGTCGCATTGAGAATTATAAGCCAGTAGCCCTACAAGTATAGGATGATGCCCATTTCAGCCTGATAATACACTCCGAAAGAGATCACATGGTAACATTGTTGCCTCAGTTAATCATAGAAATACTCAATTACTATAGAAGTAACAAGAAAAATGCTTTGTTATTCTCATGTCTCATTTATCGAGTTCTTACTATCTATCTGTTATTGTTATCCTTATACACTTCTGCACAAAAGATGGTTTTATCCCAACTTTTAGCTTAGAAACTGACCCTTAATCACTAACTTGACCAAGAATGGCTTCTCTTTCTCCATTTCCTTCCTCTCATGGTGTTGTTTTATATACATAAAATAATATATATTATTCTATTAATATAGATTAATATATCTATTTATATATCTACATTTTATATATCTATAAAACTTATGTTGTAACTTTTATATACATATAATATATATTCTGTTTATATATTGAATTTATATATATATAAAACTTAACACTATTAAGTCTTAACACTATTAAGTTTCATGGTGTTCAGTTATATAGTTCTATTAATTATATATATATCGGCGCACGCGTGTTTCTCCACCCTACACTTCCACTTTGAAATCTAGTCTCCAGCCTCAGCCACTTCTTTCACATTGCCACTTCCATGTCTGGTAGACTTAACATATTCACAACTGAATTTCAAATCTTCCCCACCAATCTGCTCTGCCTCATAGCTTCCCCTTTCCCGAATGTGGTTGCTCCATCCTTCCAGTTCTACAGGCCCCAAATCTTGCAGTTTTCCTTGACTCCTCTCTTCTTCTCAAATCCCACATGTAATCCATCAGGTAGTCTTATTGGCTGTGCCTTCACACTTTTTTCAGAAACTAATTATTCTTCAGCACCTCCAATGCTGCCACCCTCGTATAAGCTACCATCCTCAGCATCTTTCTTCCACTGGATTTTAGCATCCATGAATGATTATTTCCTAAATCAATTATCAATAATTGTTATAAATTTGTCATTTTTCTATTTCTATCCTTCCTGTCACTTTTCCTGGTTTTTTTAAAAGAGCTTTCTTCATTCTTCTTTAAAAAAAATTAAAATTAACATCACTATGAACTCCTGGATTCTTTTGTTATTCATTGTACTATAAGCCATTCCTGTCATTATTCATTTTGATTCTTAAATTGTCCTATTCTTGGCCAGTGGGAGTCTTTCATGCTAGCTCCTATGTCTTTTTCATATGTCCCTATCTTTTTTTTCCTAACACTTTCCTTATTTCTGAAATTATAAGCTATTCTACGTTCACCCTATACCTTCACTACCCCAGTCCACCCATCCTCTCTCTCTCTAAGAAGTCCTAGTTCCTTTTAGCAGGAGAAGTTTTTCTAGACTCTTTCATTAGGCAGAGCTACAAAATTGATTATTTTAAAAATCTCGAGTTCATACACTAATTCATAATTCTAATTCCAATCCAACACTCCAGGCTTCTTCCCTCCCTCCCCTCATCCCATACTTGTATTTGGATTTGAGATATCAAATGTGTATCTCATATCCCATATTTCTTCAGTAACTGAAAACCCTCATCATCAATGATAGCAGCATGCTTACTCATTTTGCTCAGTCCAATAATTCACACACATTTGTAGAAAAATAGAATAGTTTTAGAATGCCTATACCAATATCTGCAACCTTACTATATTCGGTTCAAAATTTCTTTGTAGTTCTTTTGACCAAATGTATTCAACAGAGAGCATTCAGTCAGAGTAATGTGTACAAAAGTTACTTGGATTAAATTTTTTCCTTCTGTGTATTTATGTTTCCATTGAGCTATAGAGTTAAGCTATTTTTTTATTTCTATTCCATTTTAGGGGTTTTCCCATCCCTGTTGATTTAGTAATTTTATTTTTTGAATATCAACATTTCTCAGTTTCACATCTTTCATTTATATGAGATTAACTAGACCCTTTAGAAATCATTATAAAGTCAGGTTGTTCTATTAATTTTTAAAATAGGTGTATAAAAACCAAAGGGATCAATCACAGCCTTGATTTAAAGTACGTTCTGAATTATTTCAGACACCCGAATCCATCTAAACCCAGAACATTTCATTTGTAGATTTCAAACACTTCTTGGCCTTCCTACCTTCCTTACATTTATGTAGCATGTGTTTATCCAAGGCACACCACCTGCCAGGCACAGTGCTGGGCTCTGTGTTGACACACATGAATGTGATCATCTTTCTGTAGCCCCCAGGTTACATGGCACCACAGCCAAGATACACACATGTGTGAGAGAGTAATCAGGGTATTACTCAGGATTTGCTGGAGGAATCCCTCTTCAAAGGATATTCTAAATTGGTGTCTCTGTGTGTGTGTCCGCCCGCGCGCGCATGTGTGTGTGTGTGTGTGTTGAGGTGGACTGGCAGAAAATATACCCTCCTTGAGATCACCTCCTGGCTAGATAGTCTCTCCCTTCTCTGTTTGTGATAGAATGCAAGTGGAATTTGACAGGTGTACTTCTCAAACTAGAAACTAGAGAGCTGCTATCTCAGTCACCGTAAGAAGAACGAATCACACCAAACCTACATCATTGTCTTCTATCACAGGATTTCTACAAGGGTGAGATAGTGAGATGCTGGAGATCCCTGTTTTGGTAGTTCAGGGATTCACAGCATCTCCCATGCTGGTGATGTCAACCTGAAGAGATATTTCTAGTGATAGGTTCCAGGGATCTTTCACCGAACACTTTAATATATTTTATCATTGTCCTGAATACAGCCCTATAAGGTTCTTACTAAATTTGCAGGTGACATGAAGTGATAGACAACAAACAATTTGAATTCAAATTAATTTTQAAACCTGAGACAATGGACCCAATTCTTCAGCAATTATATTTAAAAGATATAAATACATGCAGAAAACAAATTACAAGTACAGAGTGGAAGAGAGATGATTTAGCACCAACGCATGCAAAGAGATCTAGGAGTTTTAGTTAATAACAGACTCAACATGAACCAGCAATGCAATGTGACTACGAAACAAGTAATTCCTCATTAGCCTGCATTAATGGAAACACGATACATAAGACCAAGGAAGTGGTGGTCTCATTTGCACTCTGTGATGAAAGGCCACACCAGGAATACAGTGTAGTACTGCTGGGCACCACATTTGTAGAGAAATAGAAACCAACTTGAGTGTCTTCAGAGCAGAATGGTGAGAGAACTCAAACTTCATTCAAATGAGGAGTAGTTACTGAGCCTCAGAAATTTATAGCCTGGAGGATTTGGTTGTCTTCAAATATATGAATGCCTGTGATGGGGAAAAAAGGATTAAATGTGTCCTGTTGTCACAAGAGGATGAAATAAGGAGCGGTGAATGGAAGCCCCAGGCGATAGAGGTTTCAGTTGCTGCTGACAGTCAGGGCTGTCTGAGGATGGAATGTATTGCCTCAGGACAAAGTGAGTTCATTGTCACTGAATTGGTTCAAAAATGACCAGGAAGACTACAGGGCAGGCAACCTAACTTGTATTACAATAAGTAATTTTTTTCTTTTTTATTTGTATGCCCTTAGAAAGATGTTTACTTAACTTGATAAATCTGTAACAAGGGATAATCAAGATTTGGTTATAGGACAATTACAATTTTCTGACAGATCCCCCAAAATAATAGAAATTAATAGCTTACACACTACTTTATCCAACCTGTAGAATGTATAACTTACTTCATATACTTTGTGTTTACTCAGTTTATACAGGCTGAACAACATAAAGTTAAGACATAAAAGGGTTTTTTTTGCAGGTTTAAAGTACTACCATTTTTCCAAATTACTGGCTGATCCTAGAACTTTGAGAAACTTTGGTGTTTCCCCCCTTCCTACTTTTGTTTACATCATAGTACGTAGATGGTACAATATTTTGGTTAACCTCAGTCTGACACTTAGATTGTGTTCTCTTTTGCCCTATTAATGTCTAGAGTGTAAAAAGACCAGTAAAGTAGCACCAACAAATCAAACAAAATTTCCCACTTCTACTCACTTGTAATTCTCTTAATTTAGTAGGGGCTTTCCACAGGAAATCACAATAGAATAGTTGAAATGCTCTTTATCTTATGTACTTTCCTTCTGAAGAAAGGGACAGTTAATTGGCTTTGTTCCCAACATGGTCCAAATTTTTATACAGGGCAGCTGTATTTACTGTAGTACAAAGGACATTCTACACCCAATGATGTCTCTAAGTATTTTCAATAATTAAGAACCTAATTGCTTCTCTACCCAGTGCGTTTCAGTGAAAGTGATAAAATAGATTTTCTAAGCAAGAAAAATACATAATGAGGGTGGTTGTATACCTTTAACAAAAAAGAAATCAGTGATATTCAATCCCAAGTAAATTTGGATATCACAGAGTCAGAGATATTCTTAATTATTTTAAATTAAATTTGAGTCAAAAACAATGTGTTTAAAGACTTTAAAATCATTTTAAAAGAATGTTAGAAATTTACATTAATAATTTCTATTTTCAATGAATAAATGAGAAACCTAGAATTTTTGTTTTGGACACACTTTGATCATATCTAATGTGTTCTACTTCCTCTAATTATTTTTATCTTATTAGGATTTTTAAAAAACCTCTTAGATTAAAATTTCTCAGTGTATCTTTGTTTGCGTGTCTTTTTTTCTCTCTCCACTTATCTAATTGAAGCATTTCTGACATATCCTCAGAACACACAGATTCTTATCAGGACTTAACTACCCAGGGCAGGGCCCTCCTTGGATTTACTGAAAATAAACACTTTCGGTACTCAGTCTCAGTTTTAATGACAAAAGTTGAAATCTTTGCCTAACATGAAGGTTTTTCTTTGTCTCTAAATTTTGATTTTCCATGCTATCAGAGGTCCCATTGCAACAGGTAATTTGAGTCTTGATTGTATGTTTTCTCAGTTTGTAATTGTGGTGAAATGTATTTAAAATGTTCACAATTTTAAAGTTAAGTTTACCTATAAGGTTCTTTCCAACTCAGAAATTCTGTGATGCTAAACTTTTTTTTTCTAGTTTGAAAATCTCATCTTTGGATGTTGTCTTCTGTGTCCTATGCATATGACTAGGAATCATAGAATTTTAGAGCTGCAAAATGAGTGAGACATTATCTAGTGATTCTGCAAATGAAGAATTAAAACGCCCAAAGAGGTTAGGTGACTCACGCAGTATCATAGCAGTACCTGGTGACTAGAACTCTGGCCACCTACTCCAGCACTAAAAATTAACCCAAATGTTTTTATCTGAAAATTTGCAGACTTCAGGCTACCCCTGTAAATAAATAAATAAGAAGTTAAAACATATTTGAGAAAGCTAAGCTTAATATGCCACATTTGGGAAAACATGTGCCTGACACAAATGTATTTGGTGTAATAGAGAACATTCTTCCATTATACCCAAATGAAAATTTTGAACATTCTCAAAATTCTTGAATTTTQAGACATTTATGTTAAGCACAGTTTATTCAGACTCTCTATAAACTGTGCTGTCATCCCTGTTGTTTTCTCCAAGCGGAATCATACTTAAATTACAACTTTACGCAGTTTAATGTTTCCTATTTTTGCACTCCTGGGATATTTTTCAGTGACTCAGAAGCATAAACTGACACTGTGAAGTTAACGCTGTGTTCCAGTGGGAATGACAGCATGTCTCTAGGACGCTCATGCAGAAAGCCCTCCTCATGCAGCTGTCTTGCGGAGTCTCCCTGCTGGTGGTGAATGTGAGATCACACAGGGCCAGCAGCCAGGGCACTACATCTCTGAGTCTCGCTTCTGGTTTTACCTAGAGCCAACCCTTGGTGATTGTTTCCCTCCTTGGCCAACCCCCCACACAATACGAAAACTCTCTCTCAAGGTCCAATTCTATTAATACCTGAGAGGTGAATTTATAAACATTTAAGATGTTTTAGCATCTCTGCAGCCAGTGTCTCTCTAAATGAAAATTGCTTCTCGAAGTAGAAAAGCATAAGGGAGTACAACTGGCTTCAAAAAAAATCCTTTTAGGAATAAGAATATTGCCAGGGTTAGGTGTTCCTAACTGGTTTCAAGCAGAGGAGTTAGTAAAATTCCAAAACTTAATCAGCTTCATGTACTCAACTTTTGCTAGGACTTTCCAGAAACTCCTCAGGGATCCCTCAGAGTTAGATTACGCAGATCAACCCTGCCAAAGGACAGTAACCATTCAACAGCTGGATAGCCTGTTGGGCCCCACTGTCCTCAGCCTTTCCTAATGTTGCCTGGGAACACCACTTTTCTCCTCCCTCCTTTTTCAGTGTACCCTGCAGACAATTATTTATTTATTCACTACCTCTTTTAACAAATATTCATTAAGTAGGTACTGGTTCTCTTCTAGGGGTTGGAAAAACAGAGAAAATTAAATAGTGCCTTTGTCCTCAGCAAACAATCCATTTAATAGAGAGACGAAGATATGCCCTTAAATACCTGAATCACCAGCATAACCAGCACCTGCGGCTGCCATGTGGGAATTGTTGAACAAGATAATTTTTGAATGAAAGAGTAAATGACCTAATTGCTCTAATGTAAACATAAATTTCTAAGACTCGGCTAGTTGGGATGATTATAGAAGGATTCAACGGAAAGATGTATCAAACCATAGATCTAACCAGAGAAAACAGCACACCAGAAAAAGCAGCAAAGGCTCAAAAGTACAAATCTCTCAGATCCAATCCACAATAQTAAATAATTTGCTGCAATGAAGAGCACGTGGAAGGCAAGGGTGGTAACAACCCTCCACATAGTAGATAACGCCAAATCATGCAAGGATTTAAACTGTATGTTTTTAGAAAATCGGTAAGCTATAGAAATTTTATATACGAATGAGAAATTATCAGCAGCATTGTCCTTTAGGACTACAAATCTGGTAGCAATCTGCTAACTGATATTGGAAGGGAAAGCCCCAGAGACACTACTTGGAAGAATTCCAGTGATTCTTCATGAGCTAAACTAAGACTTCAACCTAAGATAGATAAACTAAGGAATCACAATCCAACAAAGCGACAAACTGAAATTTTTCGGCTGCTACTCAGCTGAAGTTTGGCAACTGGTTAAACATAAAACACAAGACACAGACAGCAATCCAAGATGAAAAGACGATTTTGCTGCACTTTTTTAGAAGCCAGCATTTGTATTTCCATTTCCAGGACGTGGAGTACCTTTGAGAAGAAAGGTGATTAGTTCAGTTTTAAGCACATTGAGCTGTAACGGTATTATGAAACAGGAAGATACCCTACAAACAGCTGGAATTTTGCACATGCTTAAAAGAAAAATGAGAACATGAGATTTCAATTTAGCCATCATCTGCATGGAGTAGACAATTCAATCCAGGAGACTTGATAAGAATGTCAAGGGAGTGATCACCATAAAGGTGAGAAATGGACTCAGCATCGATCTCTGCTCAAACATCTCTTTGAGCAGCAACAAGAGTGCCTTAGCAACCAGCCAGTCAAATCCGGACTTGGGGGAGACTTTCAAGCAAAGGGAATGGTAACATATCCCATTCCCAAAGACCTCAAGTAGGGTTGAGGAATAATAAATGGCTAGTGGGTTTGGAAACATGGAATCTGTCATGACCTTTACACACTTTTTCATTTGATGGATCGGGCGATTACTTACATTTGCAAAGGGCCTCAGATTAAGTGGTAATGGTTCAGCATTAGTAATTAGAGATTTTCTTATGTACTTTGTAGGGAGAAATAGAATGGCATTCAAACAGGTTTAAGTTCCTCTTAAGAACCTTTCTCATTGGATTGTAGAGAAGAGCAAATGAAAGAATCGTTCAGTATTTCTTGGTATCATGCCCAGCCCATAGGTTTCAATTAATGTTAACCTTTACAGTTGTCATCATCATTATCCAGAACGGGCTTTTTTTTAGAATAAGCAACAAAACCACTGCTCATCTGTAGACAAGGGAAAAAATCCTTTGGAAGAGAGAAAGAGAAGGGTAATTCAAGAAGATCAGGAATAAACATTAAGGGTAAAAACAGAATGGTTAGCCCTGGAAAAGGGAACAAACATGTTTCTCTGAATTAGGAGAGGATATGTGAAGTAACAGGGATGTTTTGACCCTCACTAACAGTAAGGACAAGAGAGAGTGAAGGAACTTGCACGCAGTGACTTCTACCTTCTCATTAAAGTCAAGAGAATCTCAACTGTTCAGATATCTGCTTAAGGTAGGAAGAGAGAAATAAGAATTGCTGTCATTTATTTTGTGGTTTTGATATAGCAAAAACTGTACTAGACACTTTACCTCCTTTAATCCTCACAAAACTTACACATTATATATTTGTATTCACATTCTACAAATCACAAAGCAAGTAAAAAAGTTAAGTAACTCTCCCAGAGTCCCCCAGATGGTCATGGGAGCCCAGATTCAGAGCCAGCTATGTCTTACTCCAAAGCCTGTGCTCTTTATTGAAACATACTCCACTAGTTTGAGATCTTGGAGGTGTACCCCTGCACTACTATCACGACTACCCCTCATAAAGTCCTGTGGCGTACTTCTTCCTATCCATCACCACAGTGAATATCAAAGAAGGGCCCTCTCATTTGAGGAATAACAGACAGTGAAATTGAGATGGACCAGAAATGCAAATCCTGGATCCCTGAGGGAAACAACAAAATGAAGCATAGAGGAAATATCTGAGTCTCGTGCCAAGACTCATCAGTACAAGAGAGAATGCCTAATGGGCAATAGCAGTTAGGGTGGCAAAAGAGAAGTACAACGGGGTGTCTTGGAATTTGAGGGAAGAACTGCTGCCTTAGTTTTCGAAGGATGATTATTCGAGAGTTGCCCTCCCTTCACTTTCTCACAGCTGGCAGAATTCCTACCTCTTAGTGGTTAGATTCCTTTTTACCAGATACTGTAGGGCCAGTGCAGCAACCAGAGCCCCCAGCCAGAAACCCTGCCTCCAATTTAGACCAGTGTTCTGCTCTGGTGTGTAATAATCATATTCTAATTTAAATAGCCTATTGAGATGCTACATTGATATCTAGCCTTTTTTTTTTTTTTTTTTACTTTTAAGTTTTATGTGCAGGATGTGCAGGTTTGTTACATAGGTAGACGTGTCATGGGGGTTTGTTGTACTGATTATTTCATCACTCAGGTATTAAGCCTAATATCTGTTAGTTCTTTTTCCTGGTCCTGTCTGTCCTCCCACCCTCCACCCTTTCATACGCCCCAGTGTGTGTTGTTTCCCTCTATGTGGCAATGTGTTCTCATCATTTAGCTCCCACTTATAAGTGAGAATATGCAGTATCTGTAATAATGGGTTTTCTGTTCTCGTGTTAGTTTGCTAAGGATAATGACCTCCAGCTCCATCCATGTCCCTGCAAAGGACATGATCTTGTTCTTTTTCATTTCTGCATAGTATTCAATTGCCCATTTTTTAAAAGACAAAATAACAAAAAAAAGAGTACAGTTATCTCCACTCCTCACCCACTACCTGCCACCTAACCCAACCCTTTATATTTTAGTAATTGCCTTCCATAAATAACATTTTATCCTGTCTTAATTATGCATTCATTAGTGTATTAATTATTGAATGCCCACAATATGACAAGCATTATTTCAAGCACTGAGGATACAGCAGAGAATAAATCAATATCCTCACTGTTTTTATTCCATTTTTTTAAGAGACAGGGTCTCACCCTCTTCCCCACGCTCGAGTGCAGTGGTGCGATCATAGCCCAATGCCACCTTGAACTTCTGGGCTCAAAGGACACTCCTACCTCAGTCTCCCAAGTAGCCGGAACTACAGGTGCACACTACCACACCCAGCTTCCCCACTCTGAGCCTCCATCCTAATGGAGAAGAGAGGCAGTAATCAAAATACATGAAATGTGTAGTTATTAGATGGTTATTAATGTATAGAGAAAAATTAACCAGAGAAACGAGCAACGCATTAGGGGGTCAAAGTTTTGGTAGGGGTAGAGTGGTCAGTGAAGGCCACCTTGAGAGATGGCAATTATGTAAAGCCTGAAAGCAGGTAAGAAATATACAGGTATACAGATGTCCCTGGAAAGAGTGTTCTAGGCAGAAGAAATAGAAAGTGCAAAACCTAAGATTGCTCACCTGGCAAGTTCAAGAACAGTGACAAACTGATGTGGCTGCATAGGACTAAGAAGAAGGACCGAGAGGACATGAGATGGTCAGATAGCCTAGAAAAGCCTTGTAAGCCATTATAACGATTTTGTCTTTTAATATAGAGAAATATTAAAGGTTTTTGTTTTAACTTTTTAACATAGAAAAATGTAATCATATACAAACACACAATAGTATAATGAGCCCCCTTGCACTAATCACTCAGCTTTAACAGCTTTCACTTTGGGAGGATTTTGAGTGAACCAGTGATAACACATGGCATGCCATGACATGCCTTCAACAGGATCACTCAGGAAAATAAGCCATGGGGAGACAGGACAAGCAGAGGAAACACAGGAGCAAAAGCTTAGGAGACAGATGATGGTGGCTGGAAACCAAGGGAGTAGCAGTGAAGGTGGTGAGAAGTGATCAGATAGAGGATATTTTTTTGAAGATTTGAATTAATATTATATATATTATACTTTAAAGAAGAATTTGAAAATCCATGTAGTGTAGTAAAGATGGTAAGAAATACAGAAAAGAGGCCAGGCACAGTGGCTCATGCCAGTAATCCTAGCACTTTAGGAGGCTTAGGTGGGAAGCTCCCTTGAGGCCATGAGTTCAAGGCCAGCCCGGGCAACATAGTGAGACTCTGTCTATATGGAAAAAAAAATTAACCAGGTGTGGTGGCATGCACCTCTAGTCCTAGCTACCTAGGAGGCTGAGGCAGCAACATTCCCTGAGCCAGGAGGTTGAGTCTTCAGTGAGCCATGATCATACCACTGTACTCCAGCCTGAATGGCAGAGCAAGACCCTGTCCCTTTAAAAAAAAAAAAGAAAGAAAAAAGAAAAAGAAATATAAGAAATGGCACTAGAATATCAGTATTATATACATTATTTTCTGTTTAAAAATCCACACAACTGGCAAAAAAAAGTGACATACATGAACATTTATAACACAGTGCATTTATAAATTACAAACTCTCTGCTCCTCCCATATTATTTTGCAGTGATGAATGATTAGGCCATCCAAACGTAAAGATTTATTTGTAATTTGCTAATGATGGAATGACACCTTTTGAGGTACAAGTTCCCAGCAATTCTTGGAATTAGCAATAGTGTGTTACTTCTTTCTCGAAAGAAGCATGATTTGTAAGCACCTATATCTGATGTAGTAAAACTGAAAGTTAAAATAAAAAAGGAAACCGTGGGTCAAAGTATGAGGGAAAAGATAAAACTTTCAGAGCAAAGTTATACATAGAGATTTTATTCATCGTCTCTGTGTAACTCACGAGAACTTCTTAGCTTATTTATTATGTCAAATGGCAGTTTGCTCTTCTAATCCCAGCCTGATATCATGAGCCATATATGCTGTTGGTCATTCAAAAAGGCCACTAAACAACGTGAAAGAATGTCAGTGAATCAATGCAACTCCATGAGTACTACCAGGAAAAGAAAAACAAAAAAACATGCCATTAATAGTGGGTCAAAGAGGATTTTTTTCATGCCATCCCCTACCTTACTGAGAATACCACATTTATATTCAGAAGACTCATAATGAATTCCAGAGTCCTCTGTGTCTTGCCTGTATGACTTTGGGTTATGTCACTTTGTTAATCTGTTTGAACTTCTGTTTTCTTATCTACAAAATACGCGTAATAGAGTCAACTCTCCCTCCCTCACAGGGACTTTCGGAGGCCCAAGGGTCTTTACAAATAATAGAGAAGGAAAGAAACTGGCACTTTAATAGTACCTACCATGTACCAGGGACTGCGTAGTCCCCACGGCAGCCCTCTGAAGTCATGTGATTGGCCCATTGTGTAGATGTAGAGCTTAAGACTCAGAGAGGTTATTTAATCTGTGTAAGGCCACAGAGCTAGGAGGGGGAAAAGCTGGGATTCGATCACTGACTAGATCAACTTGAAATCTCCTGCCTGACAGAGAAAGAAGAGACTAACTTTACTAAGCATCTTTTTATGCCAGAAACTGTGTTGGACATAATTCTGTACTATCTTATTTGGTAAAGGTCATTCTGTCCTTCCTGGTTGCCCTGGTTGCTCAACAAGTAATAAACAATAAAGCCTGACTGTTTTTCATCCCTGAGACAAGAAATATTATTAAAATAGCGTTATTCTCTTTCTTTCTTTCCTTTTTTTTTTTTTTGTGTGTGTGTGTGTGTGCGCCTGATAATCTGACTTCCAACCTCACAGAAAACAATGAATGCATGGTTTCATGTCTGTGGCATGACTCTGTGAAGGAGCCTTGCAAGGGGACAGATACACCTCTACCACTTCTTATAGCCATTCCTGAGACCTCTCTTCTCACAACACATACCAGCAAAGCCAAACAAACAAGGTGTTTAGGAATAACTGTCATCTATCAACACTCTCTAGGCAAAGTAGAACTATGAAACACTGACCACACTCCACACACACACAACAAAAAATCATCATGTCACATGGTAGCACAGAGCAATGGGAAATGTGAATAGTTTGTTGAGGTGGACAGACCCAAGCTCAACGATTGCCTGATCGCTCCATTTATAGGAACCATGGCAACCTACCTTATCTTACTGACCCTCAGTTCCTCCAGCTGTGAATCGGGTACAACCTCTGACCCCACAGGGCTGTTGTGCAACCATTATCTCAGTTAGCATGTTCCATAAACACAGTAAGTTAGAAAGTATAGCTGTATAGAACTCTGGGAGTTTAACAAGCAAGAGAATTTGACAGTAATCATTTAGTTACTGAACCCTGTCTTCATATTCCGCTAGGTTGCATATGGTTTTCCTGCCTGTCCCTTCCAATCACATTTCACAAAAACCAAACCAGTAGTGGACCCTTGTGGGCTAAAGTGGTGAGGAGGGTGTCATGGAACATTCAGGTTCAGGTCTTCCTCTTGAAGAATGGCTGCTTCTCAATAGGGAACTGGAGCAACAACCTGGCAGTTCTCACCTTGAAGAAAATCCTGAGACGTGATAATCCGTAGGTCCAAGCACGTCCTGAGTAGGACTCTGAGCACACACCCTTTCTTTGCATGTGCTGTTTTTCCTGCCAGCAACACCCTCTAAACCCTTTGCCCTCACCCACCCCCTTGCCTGGTTATACTCCTAGCCTTCTTTCAGATCTCCACCCTCACTACTCCCTCAGCAAGCTTTCCCTGACCTCCTGACCCAGTCAAGTGCTTCTTATATATCTCCTTTCTAAGCTCTTCTCAGTTACACTTTTACATTTATTTGTCAGATTATTTGATTAGTCTCAGTCCCACTCTTTAATTCTCCACAAGAACACAGATTGTGTCTGTTCTCCATTCACCATGCATCGCTTCATCCCCTAGTTTACTGCAGTCTCTGGAACATAGGACGGGCTTTAAATACTCGCTCAATAAATAGAGAAATGTTGGTTATTAGTCACGTATTACCTAGGTGGGAGAGAGGATTTATATTTGCGATTCCTAATCCCATTAAGTGCCAAGCACTGCATTAACTCATTTAATCCTAAAAAAAACTCCTATGAAATCAAGTGTATTATTCCTTTTAACTTTAAACACAGACAAACTGAAATCCAGAGATGTTAACCATCTTTCCCCGTTCACACAGCTAAGTGGTAACAGTCGGTCTTGAGCCGGGCAGCCTGGCTTCAGACTTCCTACACTTTACCACATTGTTCTGCTCCTTAGTGCAGTAGAGGACAAAGTGAGGTGCACACGTGAACTCAGGACAGATTTCCGTTTGAAAATTGTGTATTTTCCCCTCCTCTTCTTCATTACCATTCTCATCATCATCATCATCAATCACTTCACAAGCAAAGCTAAGCAGAAAAGAACTACTTCATGTATCACCTCTTACATTCATGTTAACTCTACATTCTGCCAAAGTGATTTGGCTGAATTTACCCAAAGAGCAAAGTGGACATTTCAAATCCTGATTCCTAGAAAATTATACACTACATCCTGTAACCACCTTTGAAGAACCACCATGTACTTTACCCCAACCTGACAAAATTGTTTTAAATAAAAAGAGGTAATTTCACTAAGATTCGTATGATCTGAGACCCATGGTTTCTACATCTTATTCAAAAAGCAGATCCAGCATGTGGTCATCAGTAGGTATTGAGTCATAAAGCTCCTGGAACAAAATCTTAAGTTTCATCAAGAATGCCAAGAAGTCCTGGGTGTCTCCAAGAATGATAGCTGTTACTATAATAACATAATTACTACTGCAAAATTACCAAAGCCCAATAAAATATGGCATGCAAAAAAATATTTACCCTGGAAATACAACTGACCTAAATCAGTCGTTTATTCCAGCCACCTGCTTTTAGATAGTACTTAAAAAAAAAACTTTCAGGATGGTCATATTGTTTAAAGTTCTCTAGGTGGAAGAGTACTTTACAGTAATAAATTAATAAATAAGACAAGTTAATGCTTTTAAACTACTATTATTTGTTGAGCATTGTTGTAAAAGCTTTACATGCATTAATGTATTTAGTCCTCACAACAACCCTTTGAGATACTATTATCATCATCTCCCTTTTACAGATGGGGAAACTGAGCAGTGCCCAAAGTCACACAACCAGGAAATGGGGAACTATCTTCAAGCCCAGCTGGTTTGCGCCTAAAGTCCATGCTCTTACAGTGTCCCTGGCTAGCTGAGTACTCAGTTTTGTCACCTTTGTCTCCTTGACTTTAACTGAAAGCTTAACTCTTTTTTTTTTTTTTTTTTTTTAAACGGAGTCTTGCTCTGTCACCCAGGCTGGAGGGGCAGTGTCTTGATCTTGGCTCACTGCAACCTCCACCTCCTGGGTTCAAGTGATTCTCCTGCCGCCTGCCGAATAGCTGGGATTACAGGTCCACACCACCATGCCCGGCTAATATTTTGTATTTTTAGTAAAGACAGGGCTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCTACCCGTCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCACGCCCGGCCCGAAAGCTTAACTCTTAATAAGAGCCTGCAATGTTCAGACGCTTTGAAAAAAACCTAACACACACACTTGCTCTCTATAAACTTAATTTTCAAAGGAACCACTATTCAAAGAAGTAAAAGGGAGACTGAATAAAAAGAACTAAGTTCTCCGTAGAGCAAATGAATTTCTGAATCGATTGCAAACAGTTCTCCGTCATCATGACATCCTATGAAGTATGGTCTCCCCCATGTTAGAGTGCCAGTGTCTTCATGTACCATATAACTTGCAAATAGTATCACTGTCTTCTCACACTTCAGCTTTCTTCTTTCATCAGTATTTTGGAAGTCCACAAAAACCCAGGGGGCTCCCTGTCTGTTGCCCTGTGGTCTCTGTGAAAACCAGATGATGCGATGCTGACTTGGACTCTTTCAAATGGATCCAACAGCACATGAGTCACTGGCAGCATGTTCAGCTCCTTTACCTCAGGAATTACCCAGTTCCTCATTCTTGCCACCCTTCACCCGTCAAGTAGTAATATGAAAAATACATGAGTACTTTTTGACGATACCTCGGACCTCTTTCCTTCAGTACCAGAGACTAATTGCCTCATAATGGTAACATTGAAGAGCCCAGTTATCTGACGTGATTGGGCTTTAATTATGGATTCCTTCTGGTGTCCTATTAAATTGGAAAGCCTACCTGATTTCACCCAAATGAAGCATTACCTCATGCCTTGCTCTCTTGCATTCCTGTGCTGGTGTCACTTAAAAGTCTAATTACATGGTTTATTTCGTGTTCTTTCACTCTTGATTTATTGCTGAAGAAGCCCCTCTGGGATATATCATCATAACAAAGACTGATTTCAGATGTCAACACCAAGAAACACAACTGGCATCAGCAATCTATAGAGAGTATCTAGGGACAGCAGTCAGCTTTGGAGAAAACCCAGAACTTCTCATTCCCCATCCCACATTTAAGGGCAAAGACTTTCTCCTTGTTAAAGGGAAAGCACTGAGTTCATAATTAGCTTTATACCCAGAGTTTTTTTTTTTTAATAATTATACCTGTTTAAGAAATTTTTTGTGCTTTGAGGTGGTCAAGATCAAATTTAATTAGCAACCCTCTTCGTGATTGGCTTGCTCTGGGGACCCTGCTCTTTGAGAAGGAGGTTAGAAGGTTTAGAAGCAAACCTTTGCAGCAGTTCTAGCCAAGTGCATGCATACAGGCCTTGAGGTGGAGCTGCACACTTGACTGTAGGGGAGTCTGTCCTTTGTTGACGAGTGAAACTTCTCTCCCTGCAAACCCTCTGGGGAATAATGCCAACTCTGATCAGCTTTTCGACTCTTGGATGAAATATTGGGTTGGGAAAAAGTCCCTACTAAGAAAATTGTACCAAAACCCTGCTTCAATAAAATATGAATCCATTTAATGAAGTTTATAGTAGAAGTAGCCTAGTCGAAAAGGATTCTGTCTCTTTCCAAGTATTATTGGCACGTTTAGGGTCTTCCTCAAGTTTATATCATTAGGACTTCCATCAAAGAGTTATCTTTACGTGTGATTCCCATCCTCCCTCCCTCTCTCCCTCCCTCCCTCCGTCCCATCGTTCCTTCCTCCCTTTCCTCCTTCCTTTTCTACCTTTCTTTTTCTCTCTGTCTCTCTTTCTTTCAAGCTGTGGGCTGCTTGTACAGATTTATGCATTTTGAATTACTGCATAGTTCAGAGATTTGGCGCTTAGGTTATTCAGTTCTTCAAAAAGTACAGTATGACCTAAGGAGATAGGGTGACCAACTAATCTAGGTTTTGGCTCCAAAAACCCTGTGTCCCAGAAAACCCCTCAGTCCTAGGCAAACCAGGATAGTAGTTCATCTTGTGAGGAGATTATAGTGCATTTCCAAGTATTTAGCTGAATTTATCACAGGGCTCTGACTTGATAGCATTTAACAGCGTTAAAATAAGGTCTTTTCTGTTATGTTAGTGTGACTTTAGTCTTGGCACTTTCTCAAQGAAGGAATCCAGTCTACTACAGGGGCTAGGTGACTAAGGAGAAGAAAGAGGATATCTAAGTGTTTTTTGCTAAAAATGTCATTATCTCCATGCTATTTCCTTTTTATTCCTATTGTCATCATTTTAAAGACATACCAATAAGAAATAAATTACTTTAAATAGAAAACTCTAATTTTATCAAGCAACAGCAAACAGGGGTGAAATCTAAGCATTTGTACTTAAGGAGTACACTTTTTTGAATTGAAGAAACTTACTATGACCTGAGCATATGTAACTCAATTATCAGAAGTCAGAGAGGGCTACTGAAGGCTCAGGTTTTCTAAGAGATGACTGGAGGCCAAGTCCTCAGGCTTCAGTCTTTATAGCCAAACTTCAGAACCAGGTCCCTGGCAAGATTCTCCTGTCTAATCACATGGCACAGAGTTAGGATGGACTGTTTCTGCTTACCTGCCTTCTTCCTTTGATTTCCATCAACCACCAGTTTCTTTCTCATCAATCATTTACCCAGCTTTTGTGACCAAGAATTTTGATGAGGATGCAGAGGAAGGCATGTTCTTGGTTAATAGGAAAGGAGGCTTCATGACAACACAGCATCCTCTAAGATGTGTTGCTCCAACTTTCACAATACATATTGTGTTTTAAGTGGCCTGCTTCTTGGAGTGTATCTTCCCACTACACAAAACAACCACCATTAACATTTTCATTTACTTCCACCCTGTCATTTGTTCATCACATACTTTTAAAAACAGGGCTGTAATCATGTATATACATATATGAATAACTTTATATTGTACTTTTTATACTTACTGGCTTATCATAAACATGTTTCCATGTTGCTGGAGAGTCACATATGCTAACTTTTGGAATGTGCTTCTTATATAGATCTGCAACTATGTGGGACCAGCAAAGGTTATTGTTCAGTTGGTCACAAATGGAAAAAATATCCACCTGCATGCCCACAGCCTGGTGGGAAAACACTGTGAGGATGGGATCTGCACTGTAACTGCTGGACCCAAGGACATGGTGGTCGCGTAAGTAGGGGTATATGATGCTGTGGAAGCTAGGAACAGATAGAATATAAGGATGCAGGAACTTAGATGAACACGCCCCTTTCATTAGGGACCTTTCTGAGACCCTCACATGACCTCAAAAAACTGTGTAAACTTGTGCTTTCATTTGGACTCCAGGAAGTAAGGTGACCACATGTCTGGATTTGCTTGAGACAGCCCAGTTTGCCCCTGACCTAATTGTTTATAGCACCCTCTTCTACTCTTAAAGGTGGCCCAATTTGGATGATCACTTATATGTGGTCACTTGACCTACAAGGTATTTGTGCCACTATTAATTTTTTTTCTCCTAGAAATAAAAATAAGGACAAATTTAAAGAAACATACTATACAACACAATCATCACTTTATGTATATTTTTACATTCTTGATGATTTCTTCAGTGGATTTATGGTGTGAATATGTAGGGCTTTAAGTGAATGCATAAATATCATTTCAGCTCTCTGCTGCTTAGAAAGTAATGCACAGATAAGAAGCCAAGGAATGCAAATTTATTTTGGCATTCATTACGCTTCAAATGTAAATAAAAAATGACGTATTCATTTAACGGTTGATCAAATAAAACAACCAATTTTTAATGAATCAACTTTTATAGAAGTAATTTCAATCCAAAAGAATTAAGCTTTTAAATAAGACATATTTATTGTGCTAAAAAACTTGTATTTTCATCTTCCTAATACACTAAAATGGCACACAGAATAATAGTGTAGCACACAATACAAACTCATATCTGCAATCAATAATTCTAAAAATTGTTGTTTTAAGTCTTTCTTTGGAAGTCCTTAAATGCAAAAGAACAAATTTTTAATTTTGTTTAATTTTTAAAAACATTTTTCAGGGTTTTCTAATCCTGGTTTAAATAGTTTATGCTGAAATCCCAGTTAATCTGGCTTATTCACTCAAAAGAAAGGAATTGTTTAAATCAACTATAATTAAGCTGATGGTTGCATTTCACGCTTTGAATTCCGATCAAGTTTCAAATTGGTTATTATTTTGGAGGTTCTCCTTTCATGTTCCTAGCTATTTCTTTCTTTGACTGTGAAAATATTTAAGTCTGAAAAACCTAGAGAGAGAGCTTTCTTTTAAGTCACTAAAATCGCATTCTTTTCATGTTAGAAAAAAAAAACACTCTAGATTGAACCAACAACCTTAAATTGATTTCAAAAATTAAAGTGTGCTTTATATGAACTTCTTTCAACATCCTCTTGAAAGACTCCCCTGTCTCCTGTTGTATGTCACAGTTTGTTCATCATGTCTTGTGGAATACCCTTCCAGTTCCTGATTGACCTAGGAGAGCTTTGAAATGCAGGCTAATTATCACAGTTTTACACTCATTGATCACTTAGTGTTTCTCCAGATTTATTCCAGTACGGTTCTGTCAGTTTGAAGTGTTTATTTTCTTTGCTCTTCTTTAATCCCTATTATAATCATATCCTTTAGACCAAATTTTAGATGAACTTTTCTACTACTATTTATTATTATAAAACCTCCAGTATCGTGTCTATAATTTGGTGTTTCTGTGGTTTGCTTTAGTAATCTTTCAGGATTTTAGAAAGAACTAATGGTTATTTAAATTTGAGACCTTAAAGCCGCAATACAACTAAATTGTTTCTAACCAAAGTGACCGATTCTTTCACTCTTGTAGTGCAGTGGGGTGTGGCCTCACTACTTCCGACAACTCATCAGTCATTCACTCATTCAACAAACATTTTGAGCATCTCAGCTCCTGAATTTCATCATTATGATGTCTGGTTGTAGAGCAGTGAGATTTTCTAACCCTATATAATTTCAGTGAGAAATTTAATCAAGATGCCACTTGAGAGTTACAATAGACTCAGTAGTCTTAACGTTTTTAGTGTTTCCTATGAAAAGTCAGTACTCACTTTCTAATTTGATTTTTACCTGAGAAATTTTTGCTTACAATGTTTCCCAAAATACACTATTTCTTTCATAATTCATTTGTTTCTATCTCTCTCTATATATACATTTTTAAGATTTTCAATGTCAAAACTTATTCCATTTATGTACAAACAACATCGTCCTACCATTCTCCAAACCAGTATTTTATTCCCACTACTGTTCCTCTCAACAGACGACTGGGGGCAAGTTACATGACTTCTTGGCCACCTTAATGTCTTCCCTCATAAAATCAGACAGTTTCACTACAGAATCTTATCTTCAGCCTGTTTACATCTCCAGAATTCTGGACTGAACTAACATTACGTAATATTATGAAATAACATGAGCAAACTTGCCACACACATATTTATGGTATGACATTGATTATTAGTATTTAGTTCTGACTTGTAGATAAGAGTATCACATAGAGAAACTTACCAAGATAGCCAAAATTATGTCTTAGACTTGTCAATACTAGAAATGAAGCTAAGATAACTTGTTTTCAATAATACAGATTAGGCAAAGAGTATAGATTCACAAGCAAGACACTAATCCAACATACCAAAAAAGATATCCAAAAAATGGCAATGAGAAGACAAATAACTTTTAAATTGTCAAAACCAAAAGAATTACTTTCTTTGGAGTGTTTATCTTCATCTTTCCCTCAGTATGAATTCTTAATAAACTTAGTTTCTACTTTCAAAAGGATTTTATCTATGTTATAAATATTCATGTTTTAAATAGCCAAGTCTTGATTCTGGTTTGATTGCTGTAATGTAGGGGATTTGTCATTTTAATATTTTTTAAGTTAGCTTTAATTTTGTCTTTTTTAAAATTCATTTATATAATTAGCCTTTACTGCCTTTCTTGGTAAAAAATAATAATAATAATCTTAGTTTCGTCTTTTATTTTAAACCCTGAATATCAACAATTTGTTTCAACATATTTTAGTTCGTTGACATTTTTATTCCATGGAAAATATCTGTGTTCCTTGACTTTGCTTTAGGCCAGTTCACTTACCAGTAATCACCACACTCTCTCTGCTTTCTGGCACTTTACAGACATGGAATTTTTTTCCAATTAATACATATAGCATATACCAACTGGTAAGCACTAGGAGTAGATATATAAATATCAAAATACAGAGGAGAAACAAGGCCTTCTTCAQTGTCTGTTGTTCCCCTTTTTGTCCATGAGTTCTCATCATTTAGCTCCCACTTACAAGTGAGAACATGCAGTATTTGTTTTTCTGTTCCTGCATTAGTTTGCTAAGGACAGTGGCCTCTAGCTCCATCCATGTTCCTGCAAAACATATGATCTTATTCTTTTTTATGGCTGCATAGTATTCCATGGTATATATGTACCACATTTTCTTTATTTATTTATGTTATTGATAGGGAATTTAGGTTGATTCCATGTCTTTGCTATTGTGGATACTGCCGCAGTGAACATTAACATGCATGTGTCTTTATGGTAGAATGATTTATATTCCTTTGGTTGTCTACCCAACAGTGCGATTGCTGCCTCAAATGGTAGTTCTATTTTTAGCTCTTTGAAAAATCACCACACTGCTACAAAATCAATGTGCAAAAATCACAAGCATTCCTATACACCAATAACACACAAACAGAGAGCCAAATCATGAGTGAACTCCCATTCACAATTGCTTCAAAGAGAATAAAATACCTACGAATCCAACTTACAGGGGATCTGAAGGACCTCTTCAAGGAGAACTACAAACCCCTCCTTAATGAAATAAAACAGCACACAAACTAATGCAAGAACATTCCATGCTCATGGATAGGAAGAATCAATATCGTGAAAATGGCCATACTGCCCAAGGTAATTTATAGATTCAATGCCATCCCCATCAAGCTACCAATGACTTTCTTCACAGAATTGGAAAAAACTACTTTCAAGTTCATATGGAACCAAAAAAGAGCCTGCATTGCCAAGACAATCCTAAGCCAAAAGAACAAAGCTGGAGGCCTCACACTACCTGACTTCAAACTATACTACAAGGCTACACTAACCAAAACAGCATGGTACTGGTACCAAAACAGAGATATAGACCAATGGAACAGAACAGAGCCCTCAGAAATAATACCGTACATCTACAACTATCTGATCTTTGACAAACCTGACAAAAACAAGAAATGGCGAAAGCATTCCTATTTAATAAATCCTCCTGGGAAAACTGGCTAGCCATATGTACAAAGCTCAAACTGCATCCCTTCCTTACACCTTATACAAAAATTAATTCAAGATGGATTAAACACTTAAATGTTATATCTAAAACCATAAAAACCCTAGAAGAACACCTAGGCAATACCATTCAGCACATGGGCATGGGCAAAGACTTCATGACTAAAACACCAAAAGCAATGGCAACCAAAGCCAAAATTGACAAATGGGATCTAATTAAACTAAAGACCTTCTCCCCAGCAAAAGAAACTACCATCAGAGTGAACAGGCAACCTACACAATGGGACAAAATTTTTACAATGTATCCATCTGACAAAGGGCTAATATCCAGAATCTATAAAGAACTTAAATAAATTTACAAGAAAAAATCAAACAACCCCATCAAAAAGTGGGCAAAGGATATGAACAGACACTTCTCAAAAGAAGACATTTATGCAGCCAAAAGACACATGAAAAAATGCTCTCATTATCACTGGCCATCAGAGAAATGCCAATCAAAACCACAATGAGATACCATCTCACACCAGTTAGAATGGCAATCATTAAAAAGTCGAAACAACAGGTGCTGGAGAGGTTGTGGAGAAATAGGAACACTTTTACACTGTTGGTGGGACTGTAAACTAGTTCAGCCATTGTGGAAGACAGTGTGGCGATTCCTCAAGGATCTAGAACTACAAATGCCATTTGACCCACCCATCCCATTACTGGGTATATACCCAAAGGTTTATAAATCATGCTGCTATAAAGACACATGCACACTTATGTTTATTGCAGCATTATTCACAATAGCAAAGACTTGGAACCAACCCAAATGTCCATCAGTGATAAACTGGATTAAGAAAATGTGGCATATATACATCATGGAATACTATGCAGCCATAAGAAAGGATGAGCTCATGTCCTTTCTAGGCACGTGGGTGAAGCTGCAAACCATCATTCTGAGCAAACTATCGCAACCACAGAAAACCAAACACTCCATGTTCTCACTCATACGTGGAAATTGAACAATGAGAACACTTGGACACAGGGTGGGGAATATCACACCCCTGGGCCTGTGGTGGGGTGGGGGGAGGGATAGCATTAGGAGATATACCTAATGTAAATGCTGAGTTACTCCGTGCAGCACACCAACATGGCACGTGTATACATATGTAACAAACCTGCACATTGTGCACATGTACCCTAGAACTTAAAGTATAATAAAAAATAAGCAAGTTTACAAGGGCAAAAATAAAACAAAAAAGAAAAAGCACCACACTGCTTCCACAGTGGCTGAACTAATTTGCACTCCCACCAGCAGTATATAAGTGTACCCTCTTCTCCACAGCCGTGCCACCATCTGTTATCTTTTGACTTTTTAATAAAACCCATTCTGACAGGTGTGAGATCATATCTCATTGTGTTTTAATTTGCGTTTCTCTACTCACCTTTTTCCATATGTTTGTTGGTGGCATCTGTGTCTTCTCTTGAAAAGTATCTAAAACAGTCACTTATCTTTTAAAGAAACTTTTTAAATCAGAAAAAAGGTGTTTATATTTAACCACGTATTTATCATTTGCAGTGCTGTTCATTCTGTTTCTTAGGTCAAAATTTCTATCTGGTATCATTTTCTTCTGCCTCAGGCACTTCCTTTTATTATACTGCTGATCTGATGCTGATTAATTCTTTCAGTAGGTGTATGTTTTCATAQCTTTTTATTTTATCTTTGTTTTTCAAAGATATTTTGAAGAGTATAGAATTTTACGTAGACACGCCCGGCGCAGTGGCTCACGCCTGAAATCCCACCACTTTGGAAGGTCGAGGCGCGCAGGTCACCTGAGGTCAGGAGTTCAAGACCAACCTGACCAACATGGAGAAACCCCGTCTCTACTAAAAATACAAAATTAGCCAGGCATGGTGGTCCATCCCTGTAATCCCAGCTACTCGAGAGGCCGAGGCAGGAGAATCACTTGAACCTGGGAGGCAGAGGTTGCGGTGAGCCGAGATCGCACAATTGCACTCCGGCCTGCGCAACAAGAAAGAAACTCCGTCTCAAAAAAAAAGAATTATAGGTTGACACTATTATTCTTTCACATCCTTAAACTATGTTGTTCCACTGTCTTCTGATTTGCCTTGTTTCCAAGAAGTCACCTGTCAATCTAATCTTTCTTCCTCTGTATATAATTTTTTTTTCTCTCTAGCAGCTTTTCAGATTTTCTCTTCCTCACTCGTTTTAAGCAATTTGATTATATGGATATTAGCATAGTTTCCTTCATGTTGCTTGTGCTTGGGGTTCATCGAGATCCTTAGATCTCTGGGTTTATATATTTAGTACGTTTTAAAACTTTTTGGCCATTATTTTTTCAAATATATTTTCTGTCCACTCCTCTTCATCTTCTTCTGGAACCCCAGTTGCACATATATTTGGCTATGTGAAATTTCCTACAGCTCACTCATCACCTCTTTTTTAAAAAATCTTTTTTTTCTCTTTCATTTTGGAAAGTTTTATTACTGTGTCTGCACGTTCACCAATATTTTTGTCTGTAGTGTCTAATATGTTCTTAATTCCATCTAGTGTATTTTTTCCTCTTACACATTCTAATTTGCAATTTCTATAGATTTCTTTGGGGTCTTTTTTTTTCATATCTGCCATGTTACTCCTTAACATACCAATGCTTTCTTCTTTTTCTCATCATATGCAATATATAATACCTATTCAATGTACTTGTCTACAAATTCTGTCTTCTGGATCTATTTTTGTTTAGTTTTTGTCCTAATTATGAATTATATTTTTCTATTTCTTTCCATGCCTGTTAGTTTTTTATTGGATGACAGGTATTTTGAATTTTGTATCGTTAACTCTTGGATTCCTTTTTTTTTTTTTTTTTTTTGATGTGCTTTTAAATACGTTTGAGGATTCGGATGAAGTTAAATTTGGGAACAGTTTGATTTTTTTGATTCTTTCTAAACTTACTTTTAAGCTTTATCAGAGAGACCAGAGAAACCTTTACTCTAGCCTTAATTTGACATCATTGCTAAGGCAGTACCTTTCTGAATTTTCAACCTCATGCTCCATGTATTACAAGATTTCTTGAACTATTCCAGCCCCATATGTGTTACAATAATTTTTCTGCCTCCACCTCTGTGGTGGTTCTTTTCCCAGCTTTGACATATTTCCTCACACACAGCACTCAGCTGAAGACTCCAGTGATCTCTCAGTGTATCTCTGTTTGCGGTTTCTTCCTTTCCGGTACTCTGCTTGTGAGTTTTAGCCTCCTTGGCTTCCTCCAATATTTAACTGTGTCTCCTCAACCTCAGAGATTGCCACGCTCTGTTGGGGTTCCTCCTTCCTGTGCTGCAGCCTGGGACTCTTTAGGCATTAAGCCAGACTAATTACAGGGTTCACCTTATTTATTTCCCTTTTCTTAAAGATTACTGTTCTCTCCTGCCTGTTTTCTACTGTCTAAAAACCATTTCTTCATGTATTTTACATATTTAACGTTCAAACCAGTCTCTTTTACTCTATCCTTACCTCAAGCAGAAGACTGACTTCTGTACTGTTTCATTTGTTAACCAGAGTAAATCCTTCATTATTCACATAATAAATTAATAAGGATGATGTTTTTCTCACACCGACTACATTAGGCAATATACATGAAAACCATATTATTGACAGTAAACTGTAAGATGCTACACAGATGTTTATCATTGCTATTACAAAGGAGATAAACCCCGTTTTCCTGCAGTTAGGGAATTCTATATGGGAGTAAGGCTGAAAGGGCCAAAAGATATAGGTATTGTTTCTGAAAAACTGCCTATGCTTCTATGCATATAAGTATGTCATGTTCCATATTTTTCTGTGCTGTATTAATTCATGCATTCCTTTATCAACAGATACTTATTAAACACTCATATCTCAGCCATTGTTCTACCCACTACACATCTCTGCCTTCAAGGAGCTTATTTTCTAGTGCTATATTTTCTGTTCTATGTCTTAGCTATCCACTTTTTTCATCTGCCTCGACACGTGACTTATTCTGTCTCTGGGCCTCTGGTATGAGTGCTCATTTCATTCTGCCTTATAACTCCTATTTTCTTCCCTACTTTATCTGACCTTCCTACCTTACCTTGTTCATTCTTTCCTTCAATCCACTTCTCATCAAATCTCTTTCTTTCCTCTACTAATTTTTTTTTTCTTTCTTTCTTTCTGAGTAAAAGCCAGAGATCTGGCCCCCTGCTTACCTCTCTGAATTCTTTACTTACTTCTGACAACTTGCTCATTTCACTCCAGCTACATTGACCTCCTTGCCTTTGTTGTGTTTTCAAAACACCGGCGTGCTCCTACCGCAGGAATTTTGTACTTACTGTTCCTTTTGCCACATTCATCATTCATATCTTCATGTCTTCCCCATCGCTTCCTTCAAGTTTTTGCTCAGTTGTCATCTTTTTACTGAGTGTCCTTCCTGACCTCTCCCTACTTTAAAATGTTATGCTTTTTTCTACTACCTCTCCTGTTCCTCATTCCTACCTTATTTTTCTGGATAACACTTATTGCCTTCTAAATTGTATCGTATAATTTACTTCTTTGTTTCTTCTCCGTTGTCACACTAGCATATAAATTCAGTGAAGGTAGAGATTCTTTTACTGCTGACAAAAGCATCTAGGACATTTCCTGGCACTGATAAGGATCTGCATAAATATTTGTTGAGTGAATGAATCTCCTTGGTAAAGTCCTTTTTTGTTTGCCTGTTATATTTATTGAATAGACTTCTTTGTTTCATGTACTTTAATTTCAAAAGTGAATGCCTGCAACATTTTATATATTTTCTTATAAATCATTTTCATTGCTTTTTAAGCTTATCACATATTTTGTTTTATAAATATGTAGCCTTCGTGAGATAAAAGATTCTCCATCCCTGTTTACGTGTATACTTAGATGACAACTCTAATGGTCATAAATAATTCCAACCTTATAGATAACTCAGGACAACATGAGATTATAAGTACACTTTAAATCCCATTCAGAAACCCAAGGACAATTCAAAAGGAAAATAATCATTCCAAATATAATATTCTTCTTATTCTTAAGAAGTTGTTAGTATTTTGAATTTTGAATTTTTAATACAGCTCCCATAGAAAATACTTTAAAATGAACCCCGTAAGACTTCCTCATTAAGACATATAGACACATATGCTCCCACTCCCGTAATCAAATTTCGAACTCAAATAAGCTCTGAAAACCAAAACATTCTTCCAAGTTTATTGCAGACTCATTTGGTAGTAAAAACCAATCTGACCTGATGTGTAGCTGTTTATAGTCTTTATTTTTCCATTTGGTGAGTCCAATTATATATTTCGCTGAGGAAATACTAACATGTTTGACTACATTGTGTGCCCCAGACCTGCTTAGAGTATTATGTAATATGCAGTATAGGCCATATATTGCCTTTTTAACATCAAAAATACCCTAAATTCTGAAATGCATGTAGCCCCAAGAGATTTGTATAAAGCATTGAGGGCCTGTGTATTTTTTTTTAATTTACAAGTGAAGCCAGATTCCCTAGACATTAAGTGCCTAACTTTTGGTTGTTGTTGCTGCTGCTGTTACTGTTTTTTCTCCAGCTTCGCAAACCTGGGTATACTTCATGTGACAAAGAAAAAAGTATTTGAAACACTGGAAGCACGAATGACAGAGGCGTGTATAAGGGGCTATAATCCTGGACTCTTGGTGCACCCTGACCTTGCCTATTTGCAAGCAGAAGGTGGAGGGGACCGGCAGCTGGGAGGTAAGCATCATTTTCCTGGCCTTGATCCTCCAAGGGGTCCAGGCTTTGGTTTTCATCTGTATGAATTATATGTTCATCTGCATCCCTTCCAGTCTCTACCCCACACTCCTGTCACCTTTTCCTTGCTCAGAAACCTTTGATGGCATCCTGCTACTTCTAGGATAAAAACTATAGCTCCATAGCCTGTCATACAAAGCCCTGCTTCTCTGGCCCCAGCAACTTTCAGCCTCATCTCCAGCCCACCTTGCATCCTCCTCTCGCCATCTCTGCTCTCTGAATAACTGAGGCATATTTATACCTTTGTATGTGTCTTCCTTTACCAAAAACACCCCACCGTTTCCATTTCACCCTCTCGAAAACCAATGCAGAAATCAAGACTTTGTCTAAAGAACACCTCTGTTTTACCTTCCCCAACTCACCTTATTATAAGGCATTTTTCTTTCTTTGGGCTCTGCAGACACATTATAAACTATTATCTTTATCATAAAAATTGTATGATTTTCCATTTTCTTGCCTTTTCTCAAATTTTTTTTTCAACCCCATTCCCTGTCCCACCACATGCCCCATTTCTACTTTTGTATTTTGTCCTTTACTCTGGCCGTCCAGTCGTCATCTGATACTCATGTGATTCAAAACCGATTATCAGTTTTCCACTAAATATACTCCATCTTCTGATACCCAGACTCAAAACCTTCCCATCCTCACTGACTCCCCCTCCTCGCCTGTGCTGCGAGGCTGTGGTCCAGCCATTCCGTGCTCTCTGGCATTCCACACTACATTCCATTTTCATTGTTCCACTTATAGTAGTCTTCTCCCTGGTCTCTGTCCCTCCCCACTTCTAATCAAGTTTACATCTTCTAGCCAGATAGATATTACTGAAGTTCTGTATCTTGTTGCTGCTCCGTGTCTCCGTTTTGCCTACAAAATCCAAATTCTGTAAGTTGGCTTTTTGGATCTCCCAAGAGCTGGCCTCAGGCTGCATTTCCAATCTATTTCCCGTTTTGCCCCTTCACGTCAAAGTCTACTACTTGGTAGGAGCACCATCATTTCTCACTTTCCTGCCTTGGCACATTCTTTCTATTTTTGCTCTCTCCTCTTCCTGGAATGCCTTTATCCACTCTCTTATATGAATGTGTTCAAATTCTGCCACCTTTTCAATATTCAGAGCAAATACCTCTTCTGCTCCAAAGCCCTCTGAACTCTCTCCTTCTTTGAAATCCCACATCACTTCATTTGTAGCTCTCTTGTAGTACTTGTCTCTTGAATCACTACCTTTTATGATATTATACCTTAATTATCACTATATCCATCAGCGTGAAAACTCCAGCAGGAGGGAAGGAAACAGATGTCCCTGAGTCATTCAGTTCCTTCAGAAGTTGTTTTTGAGTACCTACTATGTGCCAGGCTGTCTGCTTGGCACTGTGGAATGAGCTCACTCCCTGTGCCCAAGCAGCTCTTCGAATAATTTGCACACTTCTCAATACAGCTCCTGCCTAGTAGCGTTATTCAATTCCATTCCATCACATCCTGTGTGCCTTTAACTCTTACTGTAGAGAGGAAACGGAAAGGTGGGGGAAGGACAGGAGAGGAGGGAGGCGATCTGATACACGGAAGAGAGTTTTTACTGTAATCCGGAGAAAATGCAGGTCTTCTTTGATGCCTTTCATATTGGATGACATAAATGAGACTGTTTTTAACACTTTATTAGCAATATGAAGAGTTTCAAAAGAGGAAAAATGCGTTTTTATTCTAAGTTTACATTATTTGGGCTTTATAAAAGCATGGTCTTTTAAATGTTCACACTTCCCTGGGCATGAATGGACTGTGCTGTATGGCCCTAGATCGGGAAAAAGAGCTAATCCGCCAAGCAGCTCTGCAGCAGACCAAGGAGATGGACCTCAGCGTGGTGCGGCTCATGTTTACAGCTTTTCTTCCGGATAGCACTGGCAGCTTCACAAGGCGCCTGCAACCCCTCGTATCACACGCCATCTATGACAGTAGTGAGTACTTCACTTCCAACAGGGGGCACACCAAGAATAGACTTCCAGCCCTGCCCTGCCATTTACTTGCTAGCTGAGTCCTGGGGAAGGTAACTTAATCACTTTAAGCCTCAGCTTTATCATCTGTAAAATGTGAATAGGAAAATCTACCTTGAAAGGTTGATGTCCAGGTTAAATGAGGTATTTTAAGAGGGGCTCAATACATGTAATTCTTTTTCCTTTGATGTACATTTTTTAGTCTTTTACATGAAATGTCACATCTCATCTTATTTATGAATGTCTTGCTATAAAGATATATGGTTGATACTTTTAGAAGGGAGAATAATCCCAATTTTCTTTGGTGGTGGGGGGACTCTGGAAAGGAGTTTATAAAAGACAACTATTATTCTTACCCATTTTCTTTCCCATATGTTACTACCTTTATCAAGACAGAAACTTGAAGTTAAATGAATGAGTAGCATAGACAGCATGTGACTTCAAAATCCTATTTCAAGCCGGGTTTGGCCTCATGCCCTGTAGTCTCACCTACTTGGGAGGCTGAGGTGGGAGGATATGGAGTTTCAGCCCAGCATCACCAACATAATGAGACCCTATCTCAAAAAAAAAAAATATATATATATATATGTATATATATATTAATTTATAGTTCCTACAACTTTTTAAGAGTTTTACAGTAACCTTCACCATTTACCATGCAACTTTCTTCTTTGATTATCCATAGCATTGATTAGACAGGTATTTTCAAAAAGCCTGCAAGCATAGTACTCAGACTCATTGAAAGTTTATAGAATTTGGCCTGTGTGGAAAACTCTGTGCTCCAAGTACAACAACTAACTGAATTCTCTAATTTAAACAAGTTTGAAGGGAAGTGAAAGGTTATAAAATGATACAGACTCATACCCCAGAATCACCTTAAAATCCACCTGTTGCACAAAAAAAAAAAGGAACCTTTATCCTATTACCACAAGAAAGTTTTGCCTCTTCACCACACAGAATCCTAATTTAGTTTGGGAAAAAGAAACATAACATCCCCATTTTCCTTACCTGTAAAATAAAAGGTAGTAAGTAGTTTAAGAAAACTQTACTTTTCCTAAAGTTTTTAGGACTCTTGTAAATAGAATAATAGCAGAATCATGGAAACAAATTTGGAATTGAAGTCTTGACCTCATTGAAAGCCCAGAAATCAATTAGCTTGGTACTTCCCAATACATCAGAAAACCTCTTTCTCTTTTTGTGTCAGTCTCTCTGTCTTACAGCGAGAAACAAATACCTGTTCCTTTCTACCTCATTTGTTTTGGTGATCATAAATGACCCATGCCCAAGAAGTGTTCCGAGAATTTCAGAAGCCATTCTTGTTTTATTTACTTTGTTAGTGAAAGCATGTATTTAAGCTTTGTTTTGGTCATGTGTGCTAAGGGGAGGGTCCTACCTAAAGGACTGGCTTGTTCACAACTCAGGATTAATCATGTTATTTGTTGTTTTTCCCCTGTGAACACAAGCCCCCAATGCATCCAACTTGAATTGTAAGAATGGACAGGACAGCTGGATGTGTGACTGGAGGGGAGGAAATTTATCTTCTTTGTGACAAAGTTCAGAAAGGTAAATACATTCTGTGATCTCTGATCTCAAGAGGTGTGATCTTCACACACTACAGTTCTGAGTGTGTCTGTGAGTCACATTTCAGCACTGGACAAGAAACATCCCTCTGCTGCCACAGAAAGTCTTAAAAAGCATTTACGTTTTACCTCTTCCAAATGTAAATTGTCTGTGTTATTTTTTCCTAAGTCAACTAAATCACTTTTAGATTTCCCATGGAAGTAAAAACAAATAAGAAAACCCTGATAATTATAATCACTGACTTTCAGTATCTTTATACATTAAAATTAATATCTGTACTTTGTTAAACAAAAATAAATAATACCCCATTCTTGACACACATACAAACACACACACACAATAATGTTTTACATACTATTAAATTGTTTTTATTTCTTTTCCAATGCTTTGATATAACACTCAGAGAACTTCTCTGAACACTTCCACAGATCTGATGTTTAAGAAAAGGAAAGAAAAACAGGGAATACAGCGAAATTCTCAGAGCACATTTCTCTCACAATTTTCCCTTTGAGGAAGGTTCTTGGCGTTTATCTTTCATTAGATATATTACAACATTGATACATTAGTAAAACCTGAGGAAAATGTCTTATTTTCTCAAACTCCATTCTTTTTTTAAATAAAATGATAGTTGCAAAGTCTAGTATAATATCTATTTACTACAGGGTGAGCATTTTCAAAGTAACCAGATACCTAACTGAAAATATAAATAACTAAAATAAATCAATAAAAGACATGTGCCTTTTAAAAAAATTATCATATCAGATTAAATTCTCTGAGGTATATAGTCACAAAAAAATCCCATCAGATTTTAAAGTAAACACATATATACTTTATCCAAAAAAATTTACACCCCACGCATGCTAACTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGTGGCAGGATTCCTTCAACCCAGGACTTTGACCCTCTAGTCAGCTATTATCATGCTGCTGTACTCCAGCCTACATGACAGAGCCACACCCTGTCTCAAAAAAAAGAAGTTTACACTTTCTCTGCCTACACTAGTGTCACCCTTCTTCCAATCCACTCTGTCCAAGTAATACTCATTTCCACATTCCTGGGTGTACATACTGTGAGTAAACACAATCTCAGTACCTTTATTTCTAAATGAGATCCTTACTCATTATCATTACATTGGAATGGCTTAGTAAGAAATGTCTTGTACTTGGCTTAAAGAATCTCAATAACTAGGTCCAGTGTAGTCCTACCTGAAGGCAAAGGAGATTCTAAGATGTTTTATCCATTCCTACTATTTCTAAAATTCTACTTACATACACATAAAAACTTTCAACAAACTCAATAGTGTGGCCCTTTCTATGAAACGGAAAGTGAAGCCAGGAAGATGCCAACCTAAGTTACATTGTCACATTTCTGTAGAAGTGAATAGACTATTTATAAACATGCTGAACATGGAGTATTTATAAACACACTCCATGACTAGAGTGTGCAATTTAAGCATTGCATTTTAATTAGAAGGGACCTGATTATTATACTATTTTGACCAATTACTCAATATGAACTAACAGACTATTATAGTGACACACTTTAATACTCTGTTAACACCCTCCACTCTGAAATTATACTGTCTATGTTAAAATCCTGGTTCCTCCAAGTACTACCTGTTCAGCCTTGGATAAGTACTTAACCTCTTTGGACCCCAGTTTCTCTTTTGCAAAGTGAGGATAATAATAGTACCCATCTACATCACAAGGTTGTGGTGAGGATGAAATCAGTTAATATGTGTATATATGAAGCACTTAGAATAGCATCTGCCATACATTAATAGTAAAACTTATATAAGTTAATTATTTTTATGTACATCTATATATTGAATTGCACTGCCTCGTTCGATTCTAATATTCTTCCACCATCCTTCGTCTTTCTCAGGATTCCCTTAAGGATGGAGAAGCAGTAAGGTCAAAGATTAAAAGAAAATTCAAGTTAACTAGGTAAATCTAGTATTCTGTCATTGTCAATCAAAGTTCCGGCGCATTACTCTGGTAAATAATGAAAAAAGTCAGTGATTTGTGAAGATTTTAAAAGACTGAACCTTTTGATCTTGTTTTTTAAAAGTGTAAATAGATAGTAGGTAGAATATTAAACCAGTTTTATTTTTCAGCATGTTTATAAATACTATTTACACTATGTGAAATTACACACTTCAATGTGATTGTTTGCAGATGACATCCAGATTCCATTTTATGAAGACGAAGAAAATGGTGGAGTCTGGGAAGGATTTGGAGATTTTTCCCCCACAGATGTTCATAGACAAGTAAGTGATTTATTATTATTATTAATCCTTATTATTTTTAGACATGCGATCTCACTCTGACACCCAGGCTGCAGTGCAGTGGTACAATCACAGCTCACTGTATCCCCCAACTGTTGGGCTTGAGGGATCCTCCTGTCTCAACCTACCAAATATCTGGGACTACAGGCATGCTACCATGCCCAGCTAGTTTCTTCAGTTTTATTTTTTTTGTAGAGATGATGTCTTGCCATCTTGCTCAGGCTCGTCTTGAACTCCTGGACTTAAGCGATTATCCCACATTGGCCTCCCAAAATGCTGGCATTATAGGCATGATCCATATTACTATCATCATTTTATACTTTCTGCCTTATTGAAATTTAGTACTTAGCTTCCATCTATAAAAAAGAAAAATCATAAATATTTAACTTCCATAAAACAGTACTATTTTTAAGACTCATGCAGGTCATCCAAAAAAGTTACCTACTGTAGAGTTATGGGCAAGGTTCTGTTAGATCGTTTGCTCTGAGATGTTGGCAAGATATTTAATTGCTGCCTAATCCCCTAACCCATAAGACAGTGCCCCACAGGTCCTTTAATGAAAATGTTTTTAAGTGTTCTACCAAAGTAATTATGATGAGACCTATTTTATGATAGCACCTAATTATGATAACACCTTAAAAGGGTGTTCTAGGAGTCATCTTCTAATTGAAGCTGATGTCATCCTGTTAAATGAAGATTTCCCAATGGCAACTGATTAAATCATCACTTTAATCATTTAATAACATGATAATGCTGACCCCCCACCTTAATTATTATTCTCCTATTTACAAGTAATTGAAGAGTATTCTCCTATTTACAAGTAATTATCTGGATTGGAAACAATCCAGATATTCATCAGTAAGTGGCCAGTTAAATTATGGTCTGTCCTTTTGATGAAATATCATGTAGTTATTCAAAAGAATGAGTACTCTGCGAACTAATATAGAAAGATCTCAGTTATACAGTGTTAAAATATTTTAAAAGATGGGTGTACAACAAAGTGTGTGTAGAAATGATTCTATGTTCATGCATAAAGAAATTCTGGAAGGATACCTAACAAATTAATAACAGTATTTACCACTGGCTGGTACACTGTAGGAACTGCATGGATGGGGAACAAGAATGTCAAAGAGAATACCACTGTATGCTTTTTTATATTTTATAAGATCTTTATCCCTGTGAATATATTACATAGTCAAAAAATCAAACTGAAAAATGCTTAAATCCCTAACATACCACCAAGAACTAATGTGTTATGATGCCAATGTAAGCAATGTTTAGTTTCTTCTCTTCATCACTGGCCTGTACCCATCTCTCTCTTTCCATACCCAGTGTTTCTGATGTTGCTCTAAATAATCTTGGAGGCTTTTAAGGCTGCTTTGGAAGAGAAGAAAGTATATGCAGTGAATTTTATAAGCATGATATTTACAACTAGAAGACATTTGAAATAGACAAATGAAATAATAAAGCTTCGTAGTACATTAGCATAGCATTGTATTTTGATTTTACAGTAGCAATTTCATAAAAATGTATCGGTATAGAATTCTGAGTTTGGAACTTTCTCCAGGACACGGTGTTTTTTAGTACACTGTGTCTAAACATTGGGTATAAACAAAGCATAAGGAATGTGTTTAATGAGTAGCATTACTGCAAAAAAAAAAAAAAATGTAGTCCTACACCAACATGTGGTTCTTCGTATCCTCCAGTTTGCCATTGTCTTCAAAACTCCAAAGTATAAACATATTAATATTACAAAACCAGCCTCTGTCTTTGTCCAGCTTCCGAGGAAATCTGACTTGGAAACTAGTGAACCAAAACCTTTCCTCTACTATCCTGAAATCAAAGGTAAGTCAGTTGTTTAAAATCTTATGCTCATATTTTATTTTATTTTATTTTTGGTTTTTGTTTTGTTTTGTTTTCTTTTGAGACAGAGTCTGACTCTGTTGCCCAGGCTGGAGTGCAATGGTGCAATCATAGCTCACTGCAACTTCGAACTCCTGGCCTCAAACAGTTCTCCTGCCCCAGCATCTCAAATAGCTGGGACTACAGGTCTCCGCCACCATGCCGGGCTAATTTTTTTCTTTTTTTACTTTTAATAGAAATGAGGACTTCCTACATTGTCCAGGCTGGCCTTAAACTCCTCCCCTTAAGCACTCCTCCGGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGCTTGAGCTGCCATCTCTTCCCATTGTGCTTGTTCTGAGAAGAGGACAAGCTAATTAGAAAAGATCAGTTAGTCACCTCCTTTGAACAGCTTTCTAGTAACAGGTCCCTGGATCCATGGTGCTTATTTTTAGAAGAGACAGTAGTATATTATTTTGAGGTCATGGAATTAGTCTAGCTTTTTAAAATAATGTTATTTCCACCAAGCTTATATGAGATTTAGACATTCAGAATTTGTCTTTGAATTTGAGAATCTAACATTTATTGACTAACTCAGAGTTCAACCAGCTGAGATGAAAAAATCAGGCTTGCTGTTTAGGAGAATCAGCCAGTTAGTCAACCAGCCTCAGGCGGTGGAACAGAAAACTTGGCCAACATGCACTGTGAAACTATGAAAATGAGTAAGGCATCATTCTTTCTCTCACAAAACATGCTTTAACAAAGCGCACTCATAGCTTTCTTAAATACTTATAATGTAAATTATGATTTTAATAAGTACCGAAAGTGAAGCATCCATAAAAATATAAGAGAATGTTGAAGAQAGAGCCCTTGGTCCCTTTATTCTAAAGCAGCCTCCAAAAAGAAGGCTTCGTCAAGCAGATATCATTTGGCCCTCAGCATTTGGGGTATATTTCAGCAGTTGGGTGTTAAACAGAGAAGGAGAGGGTTCTCTAGGTTTAAGTTACTTCAGCAGCTTAAACAGACAGCTAAACACACCGTTTATGCACAGGGAAAAAAGTCTTCTGACCGCTCGGATGGACATGAAGGCCAATGTGGGTAAGGAAGGCCAGGGCCAGGCTAAAGAGGGCTGTGAATGGCAGCTTAAGAATTTTGCATTAATTCTGGAGAGGGATAGCCGGGCCTGCCTAGGTTTGGAATGATGCCTCTGACTTCTTTATGTCACCACTGAGGGTACCATTTACGAGCCAGATGATGAGTCAGAAGAGTAATGCAAGAATCCAAGTGAGAAACAGTGCAGTTACTAAAGGTCCTAGTGCCAGGAATGAAACGAGATGGTGGACTTAAGAGAGAGTGCAGTGATACTGTGATACAGTGATACTGTCAAGAGGGCCTAGAGGTCGGAGGTGTAGGAGAGACCGGGAGTCATAGATGGGTCTAAGACTCCCTGACCAGGAACCTTGTGATCTGGTTGACTTGATGAAAGCAACAAGGGAGCAAAACTAGATTTCGGTGGCAAAAGAAGCACCTCAGAGTAAAACATGTTATATTTTAGGTCCCTCTCGGAAAATCAACTGTAAGTTCTTACTAGGCAGATCAAAACGCAGAACTGGAACTCAAGAGAGGACAGGGTGAGAAATTTAGCATTAGAATCATCTCAAAACGAGATATAACAGGCACCAACTGAGTCATCATTCAAAGGTATTTCTTAACCTAGAGTCCACTGACCCCCAAAGAGTCTGTGGATAGAAATGTACTTTGATATCATCAGCTTCTTTTATAATCCTGTTTTGTATTTTACATACTGAAAACCATGATTCTGACAACACATCCATAGACTTCACCAGACTGCAGAAGGGGCTGTGGCACAAACAAAATTAGAAACCCCTCAGTTGGAGGGAAGTGAGACTGGGAAGGGAGGTCAGTAAAATGATTGCCACGGGGCACCCAGATCCTTGCTGACGTTGGAAACCGCAAACGTGCAGCAGCAACAAGCCACATGGGTGCGTGTTCTCTCCTGTGAGAGCAAGATCTGATAGGTAATCTTTGAAGAGGGCTTTCCTTTCCTAGAATTCGTGCTGCCACAGGAGTGTTTAGAAAACGGTTCTACAAGTTCTTGTTTCTTTTCTGAGGTTGTGGCCTCTCCATTGTTTGGTCAGATTTGTAGTCCACTCTATATCCTCCTCCTTTCAAAACATTGTCACCACAATAACTTTTCTTTCTTCACATGAGATTTCATACAAAATCCCAGTGTATGCACATGCTAGGCTTTGATTAAAATAGCGGTGAAGGGCCCTCCCAGCTCGGCCTTCCGAGACCCTGTCCCACCTCTCCTTACTTCCCTATCACAAGAGCTCCTaGAGGTCTTTTGAATGCTTCTCCCTACACAAAATCATGTGAATCACTGCTTTAATTTAAACACCCTTCTTTAAAACTAGACACAGAAGAAAAATATGCATAATTTTTTTAGACTTTCTGAGGAAAAAAATAAATTTCTTCTCCAGAAATATGTCTTCAAATAATCCCACTTTTTGCTAACACAGACAATCATGAAGAAACAAAACCCAGGTTACCTGTATGTGTATGAACCTAGAAACATTCAAAGCTCACCTTGGTATCTAGGCTAACCTGTCTCCCTTTCCCAGTGGTATCTATCCCTCAGAAAGTATGTTATAGTGGGGGTATATTCAGGTGATTACTTTAATGCCTCGTTATCATAGTACGAACTATCCAATGCAGGGATTAGAAATAAGGSTCACCTGAAACTTCAATATTGCACCTCTATGCTTCATGCACCTACCTTCCAGCCTCTCATTGATGAAAAGCTTCATACAATACAAAGTTTAACAACTGTCTGGAGAAATACTTACCCATTGAGCTCTSAAGSAAAGAATGGACAACATATATATATATGAGGACAACAAATTACTTCATTCTATAGAAACCTTCTCGATTATAAAAACTCAAGATAATASGACCAAGCAGAAATAATCTGACCAGGCAATATAACTGGTCAGAAAAGTAGTAGGCCATTTAGCATTAGACTAACTACATAGAAATCCATCCAAACTGTACAACCCACGCAAACATTGCATACATTTCTCAGAAGTCATTGAACACACTTTTCCTTACCCCCAGTCTCTGT HUMAN SEQUENCE - mRNA (SEQ ID NO: 29)GGCCACCGCACCGGCCCGGCCACGATCGCTGACAGCTTCCCCTGCCCTTCCCGTCGGTCGACCCCCCAGCCGCCGCAGCCCTCGGCCTGCACGCAGCCACCGGCCCCGCTCCCGGAGCCCACCGCCGCCGACGCCCCACCCGCCCGGCCAGTAACGCGGCGCCGCCCGCGGCCACCGCGGGCCCTGCCGTTCCCTCCGCCGCGCTGCGCCATGGCGCGGCGCTGACTGGCCTGGCCCGGCCCCGCCGCGCTCCCGCTCGCCCCGACCCCCACTCGGGCCCGCCCGGCCTCCGGCCTGCCCCCGCCTCTTCCTTCTCCACCCGSCAGGCCCCGCCGCTTAGGACGCAGAGCCCACCCCCGCCAGGAGGCCGAACGCGGACTCGCCACCCGGCTTCASAATGGCAGAAGATGATCCATATTTGGGAAGGCCTGAACAAATGTTTCATTTGGATCCTTCTTTGACTCATACAATATTTAATCCAGAAGTATTTCAACCACACATGGCACTGCCAACAGATGGCCCATACCTTCAAATATTAGAGCAACCTAAACAGAGAGGATTTCGTTTCCGTTATGTATGTGAAGGCCCATCCCATGGTGGACTACCTCGTGCCTCTAGTGAAAAGAACAAGAAGTCTTACCCTCACGTCAAAATCTCCAACTATGTGGCACCAGCAAAGGTTATTGTTCAGTTGGTCACAAATGGAAAAAATATCCACCTGCATGCCCACAGCCTGGTGGGAAAACACTGTCACCATGGGATCTGCACTCTAACTGCTGGACCCAAGGACATGGTGGTCGGCTTCGCAAACCTGGGTATACTTCATGTGACAAAGAAAAAAGTATTTGAAACACTGGAAGCACGAATGACAGAGGCGTGTATAAGGGGCTATAATCCTGGACTCTTGGTGCACCCTGACCTTGCCTATTTGCAAGCAGAAGGTGGAGGGGACCGGCAGCTGGGAGATCGGGAAAAAGAGCTAATCCGCCAAGCAGCTCTGCAGCAGACCAAGGAGATGGACCTCAGCGTGGTGCGGCTCATGTTTACAGCTTTTCTTCCGGATAGCACTGGCAGCTTCACAAGGCCCCTGGAACCCGTCGTATCAGACGCCATCTATGACAGTAAAGCCCCCAATGCATCCAACTTGAAAATTGTAAGAATGGACAGSACAGCTCGATGTGTGACTGGAGGGGAGGAAATTTATCTTCTTTGTGACAAAGTTCAGAAAGATGACATCCAGATTCGATTTTATCAAGAGGAAGAAAATGGTGGAGTCTGGGAAGGATTTGGAGATTTTTCCCCCACAGATGTTCATAGACAATTTGCCATTGTCTTCAAAACTCCAAAGTATAAAGATATTAATATTACAAAACCAGCCTCTGTGTTTGTCCAGCTTCGGAGGAAATCTGACTTGGAAACTAGTGAACCAAAACCTTTCCTCTACTATCCTGAAATCAAAGATAAAGAAGAAGTGCAGAGGAAACGTCAGAAGCTCATGCCCAATTTTTCGGATAGTTTCGGCGGTGGTAGTGGTGCCGGAGCTGGAGGCCGAGGCATGTTTGGTAGTGCCGGTGGAGGAGGGGGCACTGGAAGTACAGGTCCAGGGTATAGCTTCCCACACTATGGATTTCCTACTTATGGTGGGATTACTTTCCATCCTGGAACTACTAAATCTAATCCTGGGATGAAGCATGGAACCATGGACACTGAATCTAAAAAGGACCCTGAAGGTTGTGACAAAAGTGATGACAAAAACACTGTAAACCTCTTTGGGAAAGTTATTGAAACCACAGAGCAAGATCAGGAGCCCAGCGACGCCACCGTTGGGAATGGTGAGGTCACTCTAACGTATGCAACAGGAACAAAAGAAGAGAGTGCTGGAGTTCAGGATAACCTCTTTCTAGAGAAGGCTATGCAGCTTGCAAAGAGGCATGCCAATGCCCTTTTCGACTACGCGGTGACAGGAGACGTGAAGATGCTGCTGGCCGTCCAGCGCCATCTCACTGCTGTGCAGGATGAGAATGGGGACAGTGTCTTACACTTAGCAATCATCCACCTTCATTCTCAACTTGTGAGGGATCTACTAGAAGTCACATCTGGTTTGATTTCTGATGACATTATCAACATGAGAAATGATCTGTACCAGACGCCCTTGCACTTGGCAGTGATCACTAAGCASGAAGATGTGGTGGAGGATTTGCTGAGGGCTGGGGCCGACCTGAGCCTTCTGGACCCCTTGGGTAACTCTGTTTTGCACCTAGCTGCCAAAGAAGGACATGATAAAGTTCTCAGTATCTTACTCAAGCACAAAAAGGCAGCACTACTTCTTGACCACCCCAACGGGGACGGTCTGAATGCCATTCATCTAGCCATGATGAGCAATAGCCTGCCATGTTTGCTGCTGCTGGTGGCCGCTGGGGCTGACGTCAATGCTCAGGAGCAGAAGTCCGGGCGCACAGCACTGCACCTGGCTGTGGAGCACGACAACATCTCATTGGCAGGCTGCCTGCTCCTGGAGGGTGATGCCCATGTGGACAGTACTACCTACGATGGAACCACACCCCTGCATATAGCAGCTGGGAGASGGTCCACCAGGCTGGCAGCTCTTCTCAAAGCAGCAGGAGCAGATCCCCTGGTGGAGAACTTTGAGCCTCTCTATGACCTGCATGACTCTTGGGAAAATGCAGGAGAGGATGAAGGAGTTGTGCCTGGAACCACGCCTCTAGATATGGCCACCAGCTGGCAGGTATTTGACATATTAAATGGGAAACCATATGAGCCAGAGTTTACATCTGATGATTTACTAGCACAAGGAGACATGAAACAGCTGGCTGAAGATGTGAAGCTGCAGCTGTATAAGTTACTAGAAATTCCTGATCCAGACAAAAACTGGGCTACTCTGGCGCAGAAATTAGGTCTGGGGATACTTAATAATGCCTTCCGGCTGAGTCCTGCTCCTTCCAAAACACTTATGGACAACTATGAGGTCTCTGGGGGTACAGTCAGAGAGCTGGTGGAGGCCCTGAGACAAATGGGCTACACCGAAGCAATTGAAGTGATCCAGGCAGCCTCCAGCCCAGTGAAGACCACCTCTCAGGCCCACTCGCTGCCTCTCTCGCCTGCCTCCACAAGGCAGCAAATAGACGAGCTCCGAGACAGTGACAGTGTCTGCGACACGGGCGTGGAGACATCCTTCCGCAAACTCAGCTTTACCGAGTCTCTGACCAGTGGTGCCTCACTGCTAACTCTCAACAAAATGCCCCATGATTATGGGCAGGAAGGACCTCTAGAAGGCAAAATTTAGCCTGCTGACAATTTCCCACACCGTGTAAACCAAAGCCCTAAAATTCCACTGCGTTGTCCACAAGACAGAAGCTGAAGTGCATCCAAAGGTGCTCAGAGAGCCGGCCCGCCTGAATCATTCTCGATTTAACTCGAGACCTTTTCAACTTGGCTTCCTTTCTTGGTTCATAAATGAATTTTAGTTTGGTTCACTTACAGATAGTATCTAGCAATCACAACACTGGCTGAGCGGATGCATCTGGGGATGAGGTTGCTTACTAAGCTTTGCCAGCTGCTGCTGGATCACAGCTGCTTTCTGTTGTCATTGCTGTTGTCCCTCTGC HUMANSEQUENCE - CODING (SEQ ID NO: 30)ATGGCAGAAGATGATCCATATTTGGGAAGGCCTGAACAAATGTTTCATTTGGATCCTTCTTTGACTCATACAATATTTAATCCAGAAGTATTTCAACCACACATGGCACTGCCAACAGATGGCCCATACCTTCAAATATTAGAGCAACCTAAACAGAGAGCATTTCGTTTCCGTTATGTATGTGAAGGCCCATCCCATGGTGGACTACCTGGTGCCTCTAGTGAAAAGAACAAGAAGTCTTACCCTCAGGTCAAAATCTGCAACTATGTGGGACCAGCAAAGGTTATTGTTCAGTTGGTCACAAATGGAAAAAATATCCACCTGCATGCCCACAGCCTGGTGGGAAAACACTGTGAGGATGGGATCTGCACTGTAACTGCTGGACCCAAGGACATGGTGGTCGGCTTCGCAAACCTGGGTATACTTCATGTGACAAAAAAAAAAGTATTTGAAACACTGGAAGCACGAATGACAGAGGCGTGTATAAGGGGCTATAATCCTGCACTCTTGGTGCACCCTGACCTTGCCTATTTGCAAGCAGAAGGTGGAGGGGACCGCCAGCTGGGAGATCGGGAAAAAGAGCTAATCCGCCAAGCAGCTCTGCAGCAGACCAAGGAGATGGACCTCAGCGTGSTGCGGCTCATGTTTACACCTTTTCTTCCGGATAGCACTGGCAGCTTCACAAGGCGCCTGGAACCCGTGGTATCAGACGCCATCTATGACAGTAAAGCCCCCAATGCATCCAACTTGAAAATTGTAAGAATGGACAGGACAGCTGGATGTGTGACTGGAGGGGAGGAAATTTATCTTCTTTGTGACAAAGTTCAGAAAGATGACATCCAGATTCGATTTTATGAAGAGGAAGAAAATGGTGGAGTCTGGGAAGGATTTGGAGATTTTTCCCCCACAGATGTTCATAGACAATTTGCCATTGTCTTCAAAACTCCAAAGTATAAACATATTAATATTACAAAACCAGCCTCTGTGTTTGTCCAGCTTCGGAGGAAATCTGACTTGGAAACTAGTGAACCAAAACCTTTCCTCTACTATCCTGAAATCAAAGATAAAGAAGAASTGCAGAGGAAACGTCAGAAGCTCATGCCCAATTTTTCGGATAGTTTCGGCGGTGGTAGTGGTGCCGGAGCTGGAGGCGGAGGCATGTTTGGTAGTGGCGGTGGAGGAGGGGGCACTGGAAGTACAGGTCCAGGGTATAGCTTCCCACACTATGGATTTCCTACTTATGGTGGGATTACTTTCCATCCTGGAACTACTAAATCTAATGCTGGGATGAAGCATGGAACCATGGACACTGAATCTAAAAAGGACCCTGAAGGTTGTGACAAAAGTGATGACAAAAACACTGTAAACCTCTTTGGGAAAGTTATTGAAACCACAGAGCAAGATCAGGAGCCCAGCGAGGCCACCGTTGGCAATGCTCAGGTCACTCTAACGTATGCAACACCAACAAAAGAACACAGTGCTGCACTTCACCATAACCTCTTTCTAGAGAAGCCTATGCACCTTCCAAAGAGGCATGCCAATGCCCTTTTCCACTACCCCGTGACAGGAGACGTGAAGATGCTGCTGGCCCTCCAGCCCCATCTCACTGCTCTCCAGGATGAGAATGGGGACAGTGTCTTACACTTACCAATCATCCACCTTCATTCTCAACTTGTCACCGATCTACTAGAACTCACATCTGGTTTCATTTCTGATCACATTATCAACATCAGAAATGATCTCTACCAGACCCCCTTGCACTTCCCAGTGATCACTAACCACGAAGATCTGCTGGAGGATTTGCTGAGGGCTGGGGCCGACCTGACCCTTCTGGACCGCTTGGGTAACTCTCTTTTGCACCTAGCTCCCAAAGAACGACATGATAAAGTTCTCACTATCTTACTCAAGCACAAAAACCCACCACTACTTCTTGACCACCCCAACGGGGACGGTCTGAATGCCATTCATCTAGCCATCATGAGCAATACCCTCCCATGTTTGCTGCTCCTCCTCCCCCCTCCCCCTGACGTCAATCCTCAGGACCACAAGTCCGGGCGCACAGCACTGCACCTGGCTGTGGAGCACGACAACATCTCATTGGCAGGCTGCCTGCTCCTGGAGGGTGATCCCCATGTGGACACTACTACCTACCATCCAACCACACCCCTGCATATAGCAGCTCGCAGAGGGTCCACCAGGCTGGCACCACTTCTCAAAGCAGCAGGAGCAGATCCCCTGGTGGAGAACTTTGAGCCTCTCTATGACCTCGATGACTCTTGGGAAAATGCAGGAGAGGATGAACGAGTTGTGCCTCGAACCACGCCTCTAGATATGGCCACCAGCTGGCAGGTATTTGACATATTAAATGGGAAACCATATGAGCCAGAGTTTACATCTGATGATTTACTACCACAAGGAGACATGAAACAGCTGGCTCAACATGTGAACCTGCACCTCTATAAGTTACTACAAATTCCTGATCCAGACAAAAACTGGGCTACTCTGGCGCAGAAATTAGGTCTGGGGATACTTAATAATGCCTTCCGGCTGAGTCCTGCTCCTTCCAAAACACTTATGGACAACTATGAGGTCTCTGGCCGTACAGTCAGAGAGCTGGTGGAGGCCCTGAGACAAATGCGCTACACCGAACCAATTGAAGTGATCCACCCAGCCTCCAGCCCAGTCAAGACCACCTCTCACCCCCACTCGCTGCCTCTCTCGCCTGCCTCCACAAGGCAGCAAATAGACGACCTCCCAGACAGTGACAGTGTCTGCGACACGGGCGTGGAGACATCCTTCCGCAAACTCACCTTTACCGAGTCTCTCACCAGTGGTGCCTCACTGCTAACTCTCAACAAAATGCCCCATCATTATGGCCAGGAAGGACCTCTAGAACCCAAAATTTAG

[0335] TABLE 6 (human PVT1) Human transcript (SEQ ID NO: 31) Humangenomic (SEQ ID NO: 32) Human protein (SEQ ID NO: 33) Human PVT1 Genomic(SEQ ID NO: 32)GAGTTGTCAGCAACCTAGAGCCCTGAATGACTGCCTGGAAGAGCTGCCTCACCACCTGAGCATCTGTGTTAGACCAGCGGGACATTCGCTAAAGCAATTAAAACATATTTTATTCAATACTACTCACAGTCAGGGAAAGACCTGAGCTCCATTCTAATTTGTGCCCAGGTATCTGGGCATTTTAAAGGGAGAAGGAGGGATGGGGGATGGCAGGGCTTGAAATGAGTTAGGGAAGTGAAAAATTACAAAGAGCAGGAAGGGAAAAGGGCTTGGCCCATGTGACTGAGACTAGCACAGGACCCTATCTTCAGGTGTTGGCTGGAACAAACAGTAAGTTCTTTGAATTTTGTAGGCAGGCACTTTCAGGGTGGGCTCAAATCGTGCTGGGGAGGCATCCTCGTGCTGTTAGAACCATGTTAGTGTGTGTCCAAGGCTTTTTTTTTTTCTTTTTTTCAGAGACAGGGTCTCACTCTGTTGCCCAGGCTGGAGTGCAGTGGTGCAATCACAGCTCACTACACCCTTGAATTCTTAAGCTTAAGTGATCCTCCCACCTCAACCTCCTGAGTACCTGACACCACAAGTGCACACCACCATGTCTGACTAGTTTTTTTAAAAATATTTTTGTGAGATCGGGTCTCCCTCTGTTTCTTGGGCTGGTCTTGAACTGCTGGGCTCAAGTAATCCTACTTCCTCGGCCTTCCAAAGTGCTGGGATTACAGGCGTGCACCACCATGCCCAGCCTGTCCAAGTCTTTTTAGGCTGAGGTTAAGACCTGGTAAGAGATTGGTCAAGAAGAGAATCTTTGCTATCACCCTATTGGGCTTATTCCATTAGTTTACAAATGAAGCCCAGGAAATACTAATGTAGATGGGTCCCAGCAAGAATTTAAGTACTGGTAATTCTTAACAAATGTTTATGAAGAGTTTATTATGTACCAAACTCCCTACCACACCTACATCCACAATCTTCACACCTACATCCACAATCTTCACACCTACATCCACAATACCACATCTACATCCACAATCTTCATTTGCTCCTCTATTTGCAAGATCTTGTCTTTACAAAAAAAATTTTAAAAATCATTAGCCAGGTATGGTGGTGTGTTCCTGTGGTCCCAGCTACTCAGGAGGTTGAGGTGGGAGCATCGCTTGAGCCCAGGAGTTTGAGGCTGCAGTGAGCTAGGATTGCACTATGCACTCCAGTCCGGGTGACAGACTGAGACCCTGTCTCAAAATATAATAATAAATTAAACAAACAAACAAACAAACAAACAAACAAATAAGTAATCTGGCCGACGCAGATACTGAACGTTCGTTAACACAATCCCAATTCCTAATCCCTTTCCTCCTTGACTGCTTTTGCTACAGAGGTTGGAAAACTCCAACACTTGCTATCCCAGCTTTACTTGCAGCTAGCAGAGGCCATATGAGAGCTCTAGCCAATGAGGCTGAATGTTTTACCACGGGTTGGTTGGAAGGTTTTTGCTTTTTCTGGCAAACAGGACATACTTGGTTTAGGCTGCTTCTTTTACTTATTCCTGCTTTAACCATGGATTTGATGCCCAAGACCAAGAATATGCTGCTCTGACAATACTAAGCTCAAACAACAAAGAGTATTGTTTTTTACATAAGAAGAGGAAAAATGATCTCTTCTTTTATCTCTCACTTACAATTGTCTAAGTTTTCCCAGAAGCTCCCCAATAGCTTTCCTTTCACATGCCATTGGCCAGAATTGGATCAGCTGAGCCCATTCCTGAATTGATCACTAAGAAAGGAAGTAGAATCACATGCTAGGCTTAGACTGATCACTGGGTAGAATGGATACTGGAGCATCAATCAAAGCATGCCCTATAGCAGGTAAATGTGATCACAAGACAAATAATGACTTTCTGAATATAAAAACCATAGGAATAAATAACAAATTAAATGACTGGTGAATATGAGCTTATTGACATTAAAGCAAATTTATAAAACCACTCATAAACAAAAGGAAAAGGCAAATAAGACATCAGGGATATATTTTTGCAATTTACATGGCAAATAAAGTGTTAATATCTCATAAGTCACTTCTAAAAATTCACCTTAAGGAAATCATTAAGGTCATATGCAATGATTTAGTCACAAAGATGTTTGTAACAGAACTGTGTTTAATAACGGAAGTTTGCAAGCAAGATGAATTCCTAGCAATAAGGTACTGGTTAGGTAAAATATGATACAAACCTACAATGGAATGCAACAGGACTATTGAAAAACAACGTTGCAGAAATATATGTACCGTTATCAAAAGATGATTGTGATGTGTTATTAAGTGGCAAAATCAGAATACAAATAATGCACATGGTTTGTTTCTATATACCTGAAGAAAAATGTAGGAGTATGTGTGTGTGTATTTGTGTGTAATTATGTAGAAGGATGTGTATTCCAGAGTTAACAATGGCCATTTCTGATGGATTTGTTGACTTTTCTTTTTCTTTCTTTCTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCGCTCTGTCACCCAGGCTGGAGTGCAATGGCACAATCTCGGCTCATTGCAACCTCCGCCTCCCAGGTTCAAGCGATTCTCCTGCCCTCAGTCTCTCAAGTAGCTAGGATTATAGGCACCCACCACCACGCCCAGCTAATTTTTGTATTTTTAGTAGAGATAGGGTTTCACCAAGTTAGTCAGGCTGATCTTGAACTCCTGACCTCAGGCGATCCACCCACCTCAGCCTCCCAAAGTGCTGGGATTACAAGCACCGCTCCCGGATATATTTGTTGATTTTTTAAACTAGTCAGCATTCAGGTTGCATTTGTAATAAAATAAACAAGTAAAGGAACTTAATTTAGGGAACATGTATCAAAAAGTAAATGAGCATCTCAACAGCAAAGTGGTCAATGGGCCTAAGGAAAATATGTTCATAAAATAAAGTACAATGAGCCAATGATCAGGTGTGTAAGAATTTATTCTTGGTAATAAATCAGTATGTAATTAAAACAAGAATGTAATGTCTCTCTTTTTATTCCCAATCCATTCAACTGGAATGCTTTCCCCGCATGAAAAGAATAGAGCCTGGTTGGGAGTACAGGGAAATGTACAAGTTCACAGGTAAAACTGTGCTGAAGAACAATTTGTCAATAGGTAGACATTCAAAAATGCCAATTTTCTTTTGTCTGAGTTATTATTATTATTATTATTATTTTTATTTTTGAGATGGAGTCTCACTCTGCTGCCCAGGCTAGAATGCAGGGGTGCCGTCTCGGCTCACTGCAACCTCTGCCTCCCAGGTTCATGCAGTTCTCCTGCCTCACCTCCTGAGTAGCTGGGATTACAGGCACAGGCCACCACACCAAGCTAATTTTTTTTTCTTTTTTTTTTTTTTTTTAGTAGAGATGGGATTTCACCATGTTGTCCAGGCTGGTCTCAAACTTCTGACCTCAGGTGATCAGACTGCCTCGGCCTCCCAAAGCGCTGGGATTATAGGTGTGAGCCACTGCACCTGGCCCTGGTCTAGGCAATTATTTTTAAATTATTTTTATTTTTATTTTTTGAGACAGGATCTCACTCTGTCACCCAGGCTGTAGTGCAGTAGTGTGATCATAGCTCACTGCAGCCTTGACCTCCTTGGGCTCAGGTGATCCTCCTACTCAGACTCCCCAGTAGCTGGGACTACAGGCTTGCACCAGCATCCCTGGCTAATTTTTGTACTTTTTGTAGAGATCGGGTTTTGCCATGTTGCCCAGTCTGGTTTCAAAATCCTGGCTCAGGTGATCTTCCCGCCTCACCTTCTCAAAGTCCTGGGATTACAACCATGACCCATCATGCCTGGTCTGATTTTTTTTTTTTTTTTTTTTTTTTTTTCAGACTGAGTCTCTATCTGTTGCCCAGGCTAAAGTCCACTCGTGCGATATCAGCTCACTGCAACCTTCACCTCCCGGGTTCAAGCGATTCTCCTGCCTCAGCCTCATGAGTAGCTGGGATTACAGGCTTCCACCACCAAGCCCAGATGGTTTTTTCTGTTTTTAGTGGAGACGCGGTTGCACCATGTTAGCCAGCCTGGTCTTACACTCCTAACCTCAGGAGATCCACCTGCCTCAATCTTACGAAGTGTTGGGATGGTGGGAGAATAAAAATGATCAATGTGGTTCCAGGAAGCGCTGATTCATTAGGAGCTGGCTTTCTTTGTCTCTCTTGCTTGAAATAAAACTAGTCTTGGCTTCCTGTCACCTCAGGGGCAGCTCTGCTGTAGAAGACACAGGTGACTTGTTCCTGGTTCTGCCACTTGCTGATTTCCTTAGACAAGACTTCTTTGGGCCTCGGCTTGCCTGTCTGACTTCACAAGTCAGAATTATAACAATGTCCCTGCCCGGGAGCTGTTCAGAGGCTGAAGAGGAACACCAGACTCAGTAAAGCCTCCAGCCTGCCAGGTAGCGCTGGGCCCACCATGACCTGAGTCCTACCACGACAAGAAGAGGCACCCTAGAGTCTTCTGTGAAGTGCACATAGAAGAGAGACTGGGCCCAAGCCACAAAAGATAGAATGCACAGCTCGGCCCTAAACAACCATTTTCTAAGAGAAAACAAAAAGCCAATGACACAGCACACCTACATACTGTGTGGTTAGAGTGAGACAACAAAAATCTGCATCTTCATAAGATAAATCCGGAGAGACTATTGAGAGTCTATTAGTGGCAGAGAATTGAATTCAGAGGGGCCAGTTCTCCTGCTGCACAATCCAGAAAAAAAAAGACAGAAGCCGACAAGGCACAGTGGCTCACACCTGTAATACCAGAACTTTGGGACGCCCAGGTGGGAGGATTGCTTGAGCCCAGGAGTTTGAGGCTGCAGTGAGCCACAGTTGCACCACTGCACTCCAGCCTAGGGTGACACAGTGAGACTCTGTCCCGAAGAGAGAGAGAGAGAGATTGATTGAAGAGATGGAAGCTTATTCCACAGCAATGACCGTGAGCATGAAGAAAGGTGCGTCCCTCAATCTATAGGACTAATCAGTAGACAGACATTGGGAAGAGGAGAACTCAGGTTCATGGCCTCAGCAAGTGGTGCTACCTGTCATAACCACTCTTGAAGCCTTGAAGCCTGTTATGTCAGGCAGAAAGTAGGGGACAAACTTTCAAATCATACATCTACAAAGAACATTCGTCATGCACTCCAGCCATCCTCAATTGCTAGCAGTACATCAACCTATGCACATACACACTCTTCCCTTTCCTAAAATGCTCCCCATTCTCTTGGACAAATGGCAAACTCCAACCTATTTTTTGAGTTTCAGCTCTGGCCCCACCTCCCTGGGGCAGTCTTTTCAGCCTTTGCCAAATACATACCTCTCTGTGCTTCCACCACACCTGGGGTTACCCCCTCTCATTCTGTTCTCACAACATCTAGGATCTCTATCCCTTCGTTCACTCATTGGTTCTATATGGAGCTACTGATATGTGATTCCTGACCCAATAGAAAATGATGAGGGTGGCTGTTTGTCTGACTCAAGCCTTTGTGAAATGACTGATGGTTCTCTAGGCCTTTTTCTGCTGTTCTCTCTGCCTGGAACACTCTAACACTCTATCTGGTTTTTATGGCTGGCTCCTTCTTTTGTTTTTTTTTTTTTTTTTTTCCTTTCACATCGACCCTCTACCTGTCACCCGGTGGAGTGCAGTGGTATGATCTCACCTTACTCCAACCTCCACCTTCCAGGCTCAAGTGATTCTCCAACCTCTGCCTCCCAAGTAGCTGGGACTACAAGGTGCGTTGCCACCACACTCGCCTAATTTTTGTATTTTTTGTAGACATGGGGTTTGGCTACGTTGGCCAGGCTGGTCTCGAACTCCTGGCCTCAACTGATCTCCCTGCCTTGGCCTTCCAAAGTGCTGGGATTATAGGCATGAGCCACCACACCTGGACGGCTGGCTTCTTCTTGTTGGTCAAATTATCTAGTATCAATTACCTTCTTGCCCCATTTTCTCTTTAGCTCTCTGCCGAGATTTACTGTCTCAATAGCATTGACCATTGTTGAAATTACCTTGCTTATTGGCTTGTCTCCTTCTTCTGACTAGAATCTCAACCTCACAAAAGCAGGGACTTGGGCTGTCTTATTGCACTCATAGTCCTGAGGACTACCACAGTGCCTGGCACATAAGAGGAATTTGATAATGTTTGATAAAGGAATGAATGGGTTTTGTAGATAAGGATGCAGATATAGGGCCAGGCATGGTGGTTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGATGGGCAGATTACTTGAGGTCACGAGTTCAAGACCAGCCTGGTCAACATAGTGAAACCCCTGTCTACTGAAAATACAAAAAGTAGCTGGGTGTGGTGGCAGGTGCCTGTAATCCCCACTCAGGAGGCTGAGGCAAGAGAATCGCTTGAAGCCAGGAGGCGGAGATTGCAGTGAGCCCAGATCGTGCCTGGGTGACAGAGCTAGACTCCATCTCAAAAAAAAAAAAAAAAAAAAAAAAAAGAGCATGCAGATATAGAGAAGGTAAACACTGGTACTGAGCCTAAAATTATTTAATTATAGAACCAATACTAAACAACCATGAGAACTGCATTTACAGAATGGAAGTGGTAATCGAAAGACAATAGCACAACTAGGCTAGCGCAGTGGCTCATGCCTGTAATCTCAACACTTTGGGAGGCCGAGGCGGGTCAATCACTTGAGCCCGGGAGTAAGCCAGGCATGGTGGCACATACCTACTCAGGAGGCTGAGGTGGGACCACTGCTTGAGCCTGAGAGCTGGAGGCTGCTGTCAGTCGAGTTTGCACCACTGCTCTTCAGTCTGGATGACAGAGTGAGATCCTGTCTCAAAACAAAAACAAAAACAAAAACAGAAAACAACGAACAAATACAGGTGAGGTAAAGGGAGATGTGAGAAAATGTGTGAATGTAATAGCAAAAAGTTGCCTCGACTTTACAATGATGAGGCCTACAAGTAAAACATCATCATGCCACTCTTTCCTTGCTTTTCATTATCTTTTCTGAACCTTTGTAGCCTTATTTAGAAAGCAATGCTTCTCATGTGGTAAATAAATATTTAAAACACAACAATTCCTTTAGTTTTATGTTAGCTTCCTTTTCTTCTACTAAAAAAATTAGATTTCTTAAAAATTGCAACTATGAGACATTAACATTGTAAAATATTTTTCCTATCTATTTGTCAATCCTGCATCCATCTATATATCTATATCAAGATCTATGCCTATATGTATCCATCTGTGCCCAAAAAGCCCTCATCTGATATTCACAAAAATTATTTCTGGCTGATAAAATTTGTTTTTCTTCTCTATTTTTTTTTCTGCAGAGTTTTAATGTTTTACAACCTGTATGTATCTGTGTGTGTGTATATATATATATAATATCACTTTTGCAAGAAGAAAAGTGACTTTTAAAAAATGAAAGCAGGCCTGGGCACGGTGGCTCACGCCTGTAATCCCAGCACTTTGCCAAGCTCAACCGGGTGGATCACGAGGTTACGAGATCGAGACCATCCTGGCCAACATGGTGAAACCCCGTCTCTATTAAAATACAAAAAATTAGCAGGGCGTGGTGGCGCACGCCTGTAGTCCCAGCTACATGGGAGGCTGAGGCAGGGGAATCGCTTAAACCCAGGAGGTGGACGTTGCAGTGAGCCGAGATTGAGCTGCTGCATTCAAGCCCGGTAACACAGCAAGACTCCATTTAAAAACAAACAAACAAACAAACAAACAAACAAAACAAAACAAAAGCAGATATACCAAAATGTTTATTTTGGATGGTAGGAATATTAAAATATTATTTTTTCTTTGTATTTTTACTGAAAAAATCTTTTAATTCTAAAAAAGAAATTAATAAAAAGGAAAATGTGAATCTAAGATTAGTGCATGAGAGCTGGAGACCCAGACAGCGCAAACACCATCAAGCTCAAAGTTGAGTCAGTCCTGGGTGAAAGTGTCTTTTCAGCCACGGGACATTTTCCATGCAGAAGGGACTGGGCATCAACTGTCAGGACATGGACAGAGACGTCTGCCATTAGAAGCTGGTCCTCTCATAGCCCACCAGCATCCCCCAGGAGGACACTGGCTTCCTCAAGGTCACAGCCTTTGGTTTCTGGAAAAAATGATTAAGCAGTGAAAGGATTAAGGTCTCACAGCTCCTATCGCATGATGTATAGATGCAGAGGTTTCTCATCATCTTCTTTTTATATTTTAAAAGATGGATGACAACTAGATGCCAACTGCAGCTCAGGCACCTGCCCAGTCCCTCTCAGAGCCGGGCACAAAACAGACACCTGTCTAGCCCCTCACAGAGAGCCAGGCACAAAACAGACACCTGTCCAGCCCCTCACAGAGAGCCAGGCACAAAGCGGAGACTTGTCCAGCTCCTGGCAAGGAGCCAGGCACAAAAGAGATGCCCATGAGTGTAAATGAATCTGTGAAACAGGCAGAACAGGAGCATCAACTGAGTAATTGTTTTTTCTTTTTCAAATAAGAACATTTGCGTTGAGAAGCCGCCACGGGAAGAGATGTGATGAAACACTACACAGAAAGAGGGAGGAGCCTCCGGGTAGGTTCGAGTCAGTAGGATGTAGGGTACCCGGCAGGGCAGAAGAGGGGCAACCTTCTGTTCCATAATATTGATACCACCCATTTGTGTGTCCAATTTTTGCTGGTTTGTGACGTCCTTCTAGGGTCCATGAGTAACCCCCACCCCATTCCCTAGCTGGGTGCCTGACTCCCCTTAAGTGCTCAGTAGACGTTGAACTGGACGGGCGCTGGCGTGGTGGCTCACGCCTGTAATCCCAGCAATTTGGGAGGCCGAAGCGAGTGGATCATCTCAGCTTCGGAGTTCGAGACCAGCCTGGCCAACATGCTGAAACCTTGTCTCTGCTAAAATTACAAAAATTAGCTGGGCGTGGTGGCGCGCGCCTGTGATCCCAGCTACTCCGGAGGCTGACGCAGGAGAATCGCTTGAACCAGGCAGGCGGAGGTTGCAGTGAGCCATGATCGGGCCACTGCACTCCAGCCTGGGTGACAGAGTGAAACTTCATCTCTAAATAAATAAATAAATAAATAAATAAAATAAACTTTGAACTGAACAGGGCCACCTCTTACATCTGTCCAGTCTCGGGTTTATGCAGATAGAACAAGATAACCACATCCCACATGGGAGGCCAGTGTCCACTTGCTCCTTTGGAGGAACTACTGGGCATTTAAGGGACTCGTTGAACACACTCTGTAGGTCAACTCTGCCCGGAGTGGAGGGAGCTGCGCAGACCGCTGGCCCTCTGCACGGGTTTGCAACTCGGCTTCTGGAAACAGCGGCAGACGTCGAACGAGGCGAGAAGGTGCGCGCGCCCTTCTCACCAGGCCGGCGGATGCTGGCTGGTACCCAAAGAGGCGCTCAGATCACTGGAGCTGGAGCTCAGTCGGCGGTCTTCTGCGGGAACTGCACCTATCCCGGAGCATCTCTGGCCCTCCTATTTCACTGAACTCGCCTTCCTCAGCAGGAAAGTGGGAAGACCGCTTGCTTCCAGGACGGTGTGGGGAGGGTAAGAGGGCTCAGGGAAAGACCGTGGAAAGCTCGGCGCACAAGCGAGCTGGCATCACCGGGGATTCCCTCCGGCCCGGTGGGACTCCGGCGCGCTTGTAGCGAGGACCCCCAGCCCAGGGCAGAGCCTACCCTCCGCTCCCCCAGTCTGGGCCCTTGGCCGCCCCAGTCGCCCAAGCCCGCCCCGCCTCCGCGCGCGGCCCTCTCCGGCTCAGTGCCCTGCGCTGCCGGGAAGCAGGCTGAGGGGCGCACCGGGCGGCGGGCGGGGACCTGGGGAAGGCCGGGAGCGCCGGGACCGAGGACGCACGCGGCGGGCCCCGCCGCGCCCGCCTCCCCCCTCCCCCGAGGCCCGAGCGCGACCCGCCGTGACGTCACGGGCAACCCGCCAGCCCCGCGCTCCTCCGGGCAGAGCGCGTGTGGCGGCCGACCACATGGGCCCGCGGGCCGGGCGGGCTCGGGGCGGCCGGGACGAGGAGGGGCGACGACGACCTGCGAGCAAAGATCTGCCCCCGGACCCCCGCCACCTTCCACTCGATTTCCTTCCCCAAACGATGTTGGCGGTCCCTCTGACCTGTGGAGACACGGCCAGATCTGCCCTCCAGTAAGTTCCAATTTTGTCCCCTGCGTTTCTGGAAACTCTCGAGACTTGGCCCTGAGTAGGGATGCGCTGTGAGTAGTCGGACGGAGGAAAGGGGCTTTCGGAATCCAATATGTGTGTGCTAGGCGTGCACTGTCCTCATCACCAGCCTCAAGACTGGTGGCGAGTTTGGGCGTTTGGGGAGGCGGAGGGGAGGCGCATGACACCGAATGGCCGGTCCATAGACCCAATTCTGGATTTATGAACTTCATCAAACGCATATTAACTAATTTCTAAAAATACACCCCTCTGCAGTCAGAACAGATTTGGAGCCATCATGTGCTTTGGACGCCCCTCTGGCCAAACTAGAGGTCTGTGAATGTGTGATCCTCCCTCCATCCTTTGACCATCACTCCCCGCTTCCTCTCACACCCCCTCAGGGCTGGGCGAAGGTGATTTCCAAAAACTCAGTAACTCCGTGTTTTGAGACTTTCTCAGTTTTTGCATCGCATGTGAGGGTTTGTTGGGTGCTCCTAAACCCTCATCATGGTCATTCTTCTTGGCTGGGCTGTTGATTTAATTAGGTTTGCCTTCTCTTGCTAACGTGCTCTTATTTATGCCAGTGTTTCTGGTTCTGCGTCTAGACTTTCACGAAGCACACCCATGAAGCTGCATGCGTCTGTGTCTGGATCCCTCATCCCTTTTCCTGGTGGTTTGCAGGCATGCAAGATTCTTCTGTTCATCTAACCTCCTCACTTTAGGCCCTTCTAGAACATTAGAGACGACAAGAAATCACGTGCAAGGATTTAGGGACAACAGGATGAGGTTTTGGTGTTTCCTTTCTGGTATTAGGTTTTCCAGACACACGCTGTTAGCCTGTCTCTCGCCCACTCCACCACTGTGAATCCTCGCTACTGGGGCTAGTTCCTTGCTAGGAAAAAAAAACTCTAGACAAATGTGTTTGTGTGTGCTGGGTGGGCGGGGGCCCTGAGGATGCAGGGACTGTGTCTGCTGTGTTGTCTGTTATAAGATGTTTCAGACCTATTTTGCATACTGGCAGCGACAAGTTGAGACTTGTTCAACTTGACACAGTCCTCTGGTCATAGCGAATCTTTCTAAACCTCTGATCAGTCAAGAAGGGGGTTGTATCAATCCTCAGAACCCTGAGTGGAACTTTCTACAGGATTTATTAGGAGAAAAACCTTCCCGGAAGCTGCAGAAGGACAAATACAGAATCCGTGTCTCGCAGAAACCTCGTGGCCTGGTCTCCATTATTTGAGATGAGTTACATCTTGGAGGTGAGGACGTGCCTCGTGGTCTAAAGCTTCGGCACAAGGGCCCAACTGGAATTCCACTTACGGGTATCACTGTGCGGTATATGCTGTACCCATTGAATTCCCACAGGCATTTGTTAAGTGCTTGTGTTGCTGTTTTGCCTGGTTAAGAGTGGCTTATTCTTGTTGCCTCATCTATCTTGAGTGCAGAATTTTTGCATAAACGGCTTCTCTTGAAAAATACAAGTCCGTTTTTGTTTTGTTTTGTTTTTTTTCTGATTAACTTTCCTTTTCCTCTGTCTTAAACACCTTCCCCCGCCCCTCGCCACCTCCATGCTGTGTTTCTGTGGCTGCAGCTTTTCTGCACTGGAAAGGAGGAGTTCTCCCCTCTGTTCTGACATATCTGATCCCCACTAGTTTATATGATTGCTGGTCTGAAAACCTGGTGAATTCTCACTGCCCACATCAAATCAATTCCCTGTTCTTTAGTTGTTTTTTTTTTCCGCCTCCTGAGCGGTAGGCAGGCACTCTGGCTGGATTCTGGAGCCTGTGTTTGCCATGCCTGGGCCTTCTGCCTGCCCAAGATGGACACGTTTCTCTGGCAGCTTCGTCAAGAGATCTCCTGGACTATAAGACACCCTGTTCTTTCCTCCTGTTTGTGTGAGTGGCCCTGCATTTGGGCAGAGTATTGGCAGAATATCTCGGGGAACTGGAAGACTTTGCATAGTTCCCGGTCCAGCTCCTCTGGAGAGGCAGTGGCAGGCCTCCTGATGGCTGCCCCTTTGCTATTTGTTTTATATCAGGTGGCCCTTCTGGATGTCTGGCCTTTTTATTTTGCATTTCCTTTCATAGTTGGCTGCACACATAAGATTCTTCTTTTTCTCTTGTTTTGCTTTTTTTTTTTTTTTTTTGAGACAGAGTTTCACTCTTGTTGCCCAGGCTGGAGTAAAATGGCTGGATTTCAGCTCACTGCAACTTCCGCCTCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTAGCTAGGATTACAGGCATGCATCACCACACCCAGCTAATTTTGTATTTTTAGTAGAGACGGAGTTTCTCCAGATTGGTCAGGCTGGTCTTGAACTCCCAGCCTCAGGTGATCCGCCCCCCTTGGCCTCCCAAAATGCTGGGAGGCCTCCCAAGTTGCTGGGATTACAGGCATCCACCACCATGCCTGGCTAATTTTGTATTTTTAGTAGAGACGGAGTTTCTCCAGATTGGTCAAGCTGGTCTCGAACATCTGACCTCAGGTGATCTGCCCTCCTCGGCCTCCCAAAGTACTGCGATTACAGGAGCCACAGTACCCGGCCTTGTTTTGCTTTTTATTGTTTCCTCATGCAGGTTTGTGATCTCTTTGAGGGATCAGGACCACACCCCCCACCCCAATTTATATTCCCAGTGTCCATGGTGGGACCCTGACTGAGGATGGGAACAGAGCAACAATCTGCAATCATTTGGACCATTGAGTCCTGTGGACAGTCACTTCAATATCATCCCTAGAGAGTCTCAGAAATTCAAGGCCTTTTGGAATGCTGCCAAAATGGGTCCTTTGGCAGGAGCCCCCTTTGTCTCTTCTGTTTTCTGACCTCAAATAATCTAAGGAACTAATAACGGTAATAAATAACAATTAATAATAAGAACAATAATAGTGCATGTATAACATCGACATTGTTTATCACGCAAAGCATGTTCTTCACCTTCTACTCCCTACAACTCCATGAGGCATTTATAATGAAATGTCTAGCAATGGTAGACTTCTTGTTGTGGGGCAGGGTTGGTTCTAACACTTCAAATTATATGATCTCATTTAACTTTCCTATAAAATAGGATGATTATTGTTGTGGTTTTGCAGATGAGGAACCCACAGCCCAGAGAGGTTAAAAATATCCTCCCAGGTCACACAGCTTGGGAGAGGCAGAGCTGTAGAGATTTGGACCACAGTCTTCGACTTCTTAGTGTGACTCTCAGAAGTTAGAGGATAATGACGTTAAGAACAAGCAAAGGGCCGGGCGCGGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGTGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCGGTCTCTACTACAAATACAAAAAATTAGCCCGGCATCGTGCCCCACACTTGTAATTCCAGCTACTTGGGAGTCTGAGGCAGGAGAATTGCTTGAACCCGGGAGGCGGAGGTTGCCGGGAGCCGAGATCGCACCATTGTATTCCACCCTCGGCAACAAGAGCAAAACTCAGTCTCAAAAAAAAAACAACAAGAAAAGGGTATACCCCTTGGCCTTCAGCAGGAGAACACAGTGTGTCCCCCACCCTCACCGTGCACCTTACGCACAAACACAAAGCTGAACATCTTGCATGAAGATACCTCATGCTCTGCCTGCCGACCTTTTCTGCAGCCACGGAGCAGTCAGAGACAAAGGGGCCAAGAGGCCTTAGGTGAGGGCTGCCATGCTGGAAAGTTTGGGCTGTGGGTGTGGGCAGGAGTCATGCCTAGAGCTCAGAACCCTTAGTCTTGGCTGGGTGCAGTAGCTCACACCCGTAATCCCAGCACTTTGGGACGCTGAGGCCGGTAGATTACCTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAGCATGGTGAAACCCTGTCTCTACTAAAAATCCAAAAAAAAAAAAAAAAAAAAAAAATTAGCCCGGCGTGGTGGCACACCCCTGTAGTCCTAGCTACTCGGGAGGCTGAGGTAGGAAGATCTCTTGAACCCGGGAGACGGAGTTTGCAGTGAGCTGAGATTGCCAGTGCACTCCTGCCTGGGAGATAGAGTAAGACTTTGTCTCAAAAAACAAACAACCGCCTCGGTCTTTGTGCAAAATCTATAATCATTTGCAAGAGGCTGCAATCAGGTATAGCACTGGATTTTGTGACCAAAACTAGGTTTCAGGATTTAATTAAAAACAAAAACAATGTCAGGTCATAAAACACAAGACATATACATGATGTGGAAATGGTCTTATTCATTTTTTAATTGCGAAATTCCGAACTATCTGTTTTTTTTTTCCTTTATCTTTTCCTTTTTGTGTGTGTGTGGAGTTAGGTGGGGGGGGAGGTATGGCATATTGTTTTGTTTATCTGCCTCTTTATTATCACTGACTGTGAAATTCTTGAGAACAGCGGCCTCTAAGTGCCCAACACAGCCCTGGTACTTTGTTGAATCAGGTGGCTGTCAAGAGCTGCTGCTTCAGCCCGGCATGGTGGCTTATGCCTATAATTTTTGCACTTTGAGAGGCTGAGGCAGGAGGATTGCTTGAGCTGAGAAGTTTGAGACCAGCCTGGGCAGCAGAGTGAGACTCTGTCTCTGTAAAAAATAATAAAATAAAAATTAAAAAATAAAGAAAGAACTCCTTTGTCTTCAAGGAAACAAGATACACAGTCAACACTCATTATCTTTTTAGATATCAGACAGCTTGACATGGTGTGGAAGTGGGGGGCTTGCCTGTAGGGAAAGTATGCTGATGAAAAAGAAGGAAAACAGACAGTAGCAGGAGGCAGTGGGGATGTGTCAGGGAGCTCAGGAGTGTAGATCTGGTTACTTTTGCGCAAGTTACTTCTCTAAGCTTCAGTTTCCTCATCTATAAAATGGTTTGCTGTGATGACGPAAGAGATCATGAACACAATGTGTCTGGCAGAGGACCTGGGCTCATAAGTGAGCACACAGTAAAAGGTAGCTAATATCATTACTGTTCCAATTATTGAGCTTTATTACTTCCTGTGGCTGCATGAAGTAGTGGTTTCTGAATAGAAAGGCAACATTCTAGTTGCCTAGATCTTAAGATGCCAGTGACTTCACTGTAGTTCTCTGCAAGCATCAGAAACAAGCCCTGGCTTATGTAAGTTAGAAACAGATGAGAAAGTAAATAAAGCTGCAGAAGTGGGTCTCACGAAGCACAGCAATCAAAGGGCTGTCCCTCGGATGTCAGACTGCCTTTCCAACTTACTTCAGGTCACTGTGCCTCCATTTCCTCACCTGCTGAGCAGGGGAGGAGAATCACTTCTCCCTCCCTGGGATGGTGCAGAGCACTTAGCAGAGCACTTAGCACAGAGGAATAAGCCCTTCAGTAAAACATTTGAGTAAAGCAATTATTATTTATTATTCTTCAGGGCTCTTTTTTTTTCTGGTGCATTAGCCCTAACATTCACTACTTCGTTCAAGAGTGATGGATGCATTCATTTCCTGAGCAGTTGCTGTATGCCTGGCACCGTTTTAGCTGCTGGCGATCCAGCAGGGAGCAGAAGAGACAAAAATCCCTGCCCTCCTGAAGCTTCTGTCCTAGTGGATGTCACACAGTAGTGGGGCAGGCTGGTCCCCAGAGACAGCTGGGGGACAGATGGAGGCACTGCAGGCAAAAGCTAACTCCTGTGCAAAGTCTCCCCGCCCCCACTGTGTTAACAGTAAAGTGCTTAGCAGAGGCTCCCACACATAGTAGTTACTATGTAGTGCTAGTTGCTATGTTTATTATTATTATATTATTCTCCTCCCTCATAAAATGCCAGCCTCCCTTTCTTCCATTCCCCTTCCTGAGTTATTTTTTCTCGATAGGGCTTATCTTCCTAGTATACCATATGTCTCTCTTCTCCCACTAAATTGTAACCCATTCATTTTTCCAGGATATATTTGTTGGGTGTCTACTCTGTGCCTGGCATTGCTGTAGATGTTGGGGATGCAGAAAGGAAGAAAAAGGACAGATTTCCATGCTAGAGCTTAGGTTACAGCTGCCTTAGACACATAACGAACAGCACACATAATAAAGAAGGACATGAATTGTGTATTCAACATTATCAAGTGCTGTGCCAACAGGCCTAGCAGGGTCACTCTCTCGAGGGCTGGGGCGTGGTGCTGTGTCGTTAAGTTGTCCCCTCACAGTCAGGCCAGCCTCCATGGAGGAGCTGACCTTAACCTCCACCTCAAGTACGCGAACGACAGGCGTTTCAGGCTCTCGGAAGAGCTAGGACAGACGTGGACGCAGAAGTCAGCCTGTGGGGGTGAGCAGCACCCAGGAGAAGCGTGAGATCAGAATGGCGTGAGCAAGGGACGTACGAGAACCCGAGCAGCATCCACTCTGCACCCTCACAGAGAGCCTGCACGCCATTCCAAACATTCTGTCTTTTACTCTGTAAAATGGCCACCCCTTGCCGTCTTTTTTGTTTTTGTTTTTTGTTTGTTATGAGGCAGAGTCTTGCTCTGTTGCCCACGCTGGAGTGCAGTGCGGAGATCTTGGTTCACTGCAACCTCTGCCTCCTGGGTTTAAGCAATCCTTACACCTCAGCCTCCTGAGTAGCTGGGATTACAGGTCCCTCCCACCACGCCTCCCTAATCTTTTTATTTTTCTAGAGATGGGGTTTCACCATGTTGGCCAGGCAGGTCTCAAACTCCTGAACTCAAGTGATCCACCCACCTCAGCCTCCCAAAGTGTTGGGATTACAGGTGTGAACCACTGTGACTGGCTTCCTTGCAGTGTTCTAAAAAGGAAAGTAATTTGATCTGACTTGGCTTTTGAAACGGTCAGTCTGGCTGCTCTCTTGACAAGAAACTAAATCACGGTCAGGAGCTAGAGCACCAGGACAAACATGCACACAGCGTTAACTGCCACGTCCACCCTCGCAGTGGTGGATGGGGCCACAGGAATGGACTTCTAGGCTGTTCACTGTTGTATCCCCAGCATCTTAAACTGTGCTCTCCATATGGTAGCTGTGAGCCCTATGTCGGTATTGAGCACTTGAAAGGAAATTGATATCTACTCTGTGTTAAACGCACATTGGATTTCAGAGACTTAGTCAGAAGAGTAAGATATCTCATTATTTATTTATTTATTTATTTATTTATTTATTTACTGAGACACAGTCTCACCTGTTCCCCAGCCTGGAGTGCAGTGGCATGATCTCGGCTCATTGCAACTTCCGCCTCCCGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGTCCCCACCACCACACCTGGCTAATTTTGTATTTTTAGTAGATATGGGGTTTCACTATGTTGGCCAGCCTGGTCTTGAACTTCTGACCTCAGCTGATCCATCCCACTCAGCTTTCCAAAGTGCTGGAATTACAGGTGTGAGCCACTGCACCAGGCCTATTTGTTTATTTATATGAGACACGGTCTCACTCTGTCACCCAGGCTGCAATGCAGTGATGTGTTCATACATCATTATAGCCTCGACCTCCCACGCTCAGCTGATCCTCCCACCTCAGCCTCCTGGGCAGCTGCGACCACAGGTCTGTCTCACCACGCCCAGCTAATTTTTTTGTATTTTTGGTAAAGCTGGGGTCTCCCTGTGTTGCCCAGGCTGGTCTTGAGCTCCTGGGCTCCAGCAATCTGCCTTCCTCAGCCTCCTATAGTTCTAGGGTTACAGGCGTGAGCCACTCCACCCTGCCAAGTTATCTCATGAACCAATTCTTTGATCTTAATTACATATTCAACTGATAATGTTTTGGATATATTGGGTTAAATTATTAAAATTAATTTCATCTGTTTTTTCTAACTTTATGGCTACTAGAAAATCTAAAATTACATGTGGGTTGAATCATATTTTCGCTGGATGGAACAATGCCTTGCACGAGGTCAGCATTTAGTGAATCAAATGTCTGGGTGAGGCACAGGTCTTCTCCCGTCAATCACAAACCGTTCCCATCTTCGGGAAGCTTCCAGTGTGGGAGGGAGGCACACTGCAGATGTAACTGCTAGGAGAGAAAGAAGGCAGGTTGAAATGGGACCACAGCCAACCAGGCCTGCTGTAGCCCAGAAGCTGCAACAGACTCGCCCAGGAGGGAAGGAAGACACTCGGGTGTTGGGTCTCAGTCTGGGTCTTGGTGACAGCAGTGGCCTGGCAGTGCACAGGTTCAAGCCCTTGGACTGCAAGTCCACTAAGGTGGCTGGTGGTGTGGGTGGAGGTGGAAAAGGCAGGTGGGGCGAGGGTGAGGGGCAGGACATCCTGGAGAGCCTGAATAACCAGGTATAAGTGATTTCTTTTTCTTTCTTTCTTTCTTTTTTTTTTTTTTTTTTTTTTTTAAGACGGACTCTCCTTCTGTCGCCCACGCTCGAGTCCAGTGGCGAGATCTCCGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCACCCGCCCACCACGCCCGGCTAAGTTTTTGTATTTTTAGTAGAGACGAGGTTTCACCATGTTAGCCAGGATGGTTTCGATCTCCTGACCTCGTGATCCGCCCGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGACCCGCCGCGCCCAGCCCCAGGCGGAAATTATTTCAACTGGGTCCTGAGAACTGGGCACTTTTCAAGGATTGTCAGCAAGGAGCAACTTCCCAAATATACATCTAAAAAGATGACAAACTCATGTGGAATGTGGATTTAAGGAGGAAGGTACTTGACTTAAGAATTCCACGATTTTGGTGGAAGAAGCAAATATGGCCCAGGCACTGTGGCTTATGCCTGTAATCCCATCACTTTGGGAGATAGAGGTGCCAGGATTAGTTGAGCCCATCTGAGACCAGCCTGGGCAACATAGTGAGATCCTGTCTCTACAGTTTTTTTTTTTTTTTGAGACGGAATCTTGCTCTGTCATCAAGGCTGGAGTGCAGTGGTGAGATCTCAGCTCACTGCAACCTCCGCCTCCTGGGTTCAAGCGATTCTCCTGCCTCAGCCTTCCGAGTAGCTGGAGTTACAGCCTTCTGCCACCATCCTTCGCTAATTTTTGTATTTTTACCAGAGACCGCCTTTCACCATGTTGGTCAGGCTGATCTCGAACTCCTGACCTTGTGATCTGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCACCTGGCCTCAAAAATTCTTATTTTTAATTAACTGGGCTTGGTGGCATGTACCTGTAGTTCCATCTTTGCTGGCACGCACCTGTATTCCCATCTACTTGGGAGGCTGACGCACCAAGCTTGCTCGAACCCAGAACTTTCAGCCTCCAGTCAGTTATGATTACACCACTGTACTCCAGTCTGGGTGACAGAATGAGACCCTGTCTCTAAAATAAATAAATAAATTTTTAAAAGCTGGGAGGTGGGGTTGGTAAATTCATAAAAAATAATATTTCTTGAGTTGAATACAAACAATACAATCACTGTTTTTTCTTTGCCTTGTTTTATTTTTACTTATTTATTTATTTTTGCAGACATTGGGCCTCACTCCTACCCTGGTCTTTAACTCCCGGCTTCAAGTGACCCTCCCACTTTGGCCTCCCAAAGTGTTGAGATTACAGGTGTGAGCCACTGTGCCCAGGCTGTGGTTTTTTATTTTTTAATTTTTTATTTTTTTGTATTATAATCATAGTGTATATGTTGCATCCTGATTTTTTTTTTTTTTTTTTTTGACACAGCATCTCATTCTGTTATCCAGGCTGCAGTGCAGTGGCACAATCTCAGCTCACTCCAACCTCTACCTCCCACGTTCAAGCGATTCTTCTGCCTTGGCCTCCGAGTAGCTGGGATGCCACCGTGCCCGGCTAAATTTTTTTTCTTTCTTTCTTTTTCTTTTTTTTTTTGTATTTTTAGTTCAGACAGGGTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAAGTGATCCCACCTCGGCTTCCCAAAGTGCTCGCATTACAGCCTGAGCCACCACATCTGGACACATCCTGATTTTTTTCTTAGTTGCTATTAGGACACACGCATTTTTGAATATTATATGCACTTTGTCCATGTCTTTTTTTTTTTTTTTTTTTTGAGACGGAGTTTCACTCTTGTTGCCCAGGCTGGAGGGCAATGGCGCGATCTCGGCTCACTGCAACCTCTGCCTCCCGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCTGGGTAGCTCGCATTACAGCCGCTCACCACCACGCCCGGCTAATTTTGTGTTTTTAGTAGAGACGGGGTTTCTCCACGTTGGTCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCCACCCGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGAGTGAGCCACTGTGCCCAGCCGTCCATGTCATTTTTATTGGGTAGATATTTCTGTTCAGTGACTGTTTCCTTGCTTACTTTATCATTCCTTTGATTTGGATGCTTAGCTTCATAACAGCCTGTTTATATAGATTATGTTTTCTATTTTTCAGTTAATTAAAAAAAAAACAAATTCTCAGTCCTAGGATTATTGTGCATAATGTCTGAATTTTTTAGAATTTCAGGTAAATATTGTGGTTCATGAGATTTGCACAGAAGCTGAATTTGCTGCTTTCTCGTGAGGCACGTGATGTTTTTTGCTGTCCGTGATGCACTAACATGTCATTAACATGTATGTACAGTGTTATATGCTCGCACATGTTTATGTGCAGCCTATGCACCTGTATTGGATTTTTCTTCACTCTCATTTATTGGCAGGTATTTGTGGAATGCCTGTCCTCTGCCAAGTTCTCCTTGAGGCCTTGGGTATTCAGTAGTGATCAAAGTAGATCAACTAGTACCAGTTCTTAAGAGGCTTATTGTTAAGTGCGGCAAACAAGCAAATAGACAAAGAAAAAATAACATTATTGTAAGGAATATGAAATAATATGTACTAGAATAATATGAAGGGATGGTTATTGTGAGGTAAGGGGGTTCATACTGAAATACTGTCTGAGGAATCAGGATTTGAGTGAGACACGAAGACTCAGTAGAAGTTAACCAGAAGAACAAACTGTTAGCAGAAAAGACAAGATTGATCAATATGACTACATATTAAAGAAAAAGGCACATCTAAGCAACAAAAACTGCAATGGTATTAAAAGCCAAATACAAGACTTAGAAGATATTTGCAATATTTATAACACATTACAAAACACTAATATCTAGAATGTATGCAGAATTCCCAAAAGTCAACAACAAAAAGACAAACAGCCTTATAGCAAAGTGGGTGAAAGATAGGACCATGCAGTGCTCATACAAAGCAAAGTAGATGGCTGGGCACCGTGGCTCATGCCTATAATCCCACCACTTTCGAAGGCTGAGGCGGGCGCATCACAAGGTCAGGCGTTCGAGACCATCCTGGCCAACATGGTAAAACCTCATTTCTACTAAAAATACAAAAATTAGCTGGGTGTGGTGGCGTGTGCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCGCTTGAACCTGGGAGGCATAGGTTGCAGTGAACCCAGATCTTGCCACTGCATGCCAGCCTGGACACAGAGAACGACTCCGTCTAAAAAATTAAAAAAAAAAGCAAAGTGGATGATAAATGTGAAAAGATTCTGAATTTTGCTAACAAAGTCAGCTTTTGGAGATCTAATTTCTAGTCAGTAAAATTCATCCTTTCTACCATACAATGCTAACACTTTTGATAAATGCATAGAACTGTGTTACACTGTTGTGTAATTACCACAATCATGGCTTAGAACATTTCCATCGTTCACCCAGATTCCCTCCTGTCCCTTCACAGCCAGTCTCCTTCTCCACCCCCAGCTTTAACCAACCCCTGAGTTGTTTGCTGACCTTACAGTGTTGCCTTTTTCAGAGTGTCCTATAAATGCATTCATACAGTGTGTAGTCTCTCGGATTTGTCTTCTTTCACCTGGCATAATGCATTCGGGACCCTTCCATGTTGTTCTATGCATCAGGGGTTTGGTAGTTTTTATTGCTGACTGGGACTCTCTTCTATGGATATACCACTGTTTGTTTATCTGTTCTCCATTTGAAGAGCATCTGGGTCTTTCCACAAGATACATGTTTCATGCTTTACAACGTGCCAGAAATAGGATGTCTGACTCAAGTGTTGACAAGGCACAGGGTGTTCAGCAGCTCCGCTAGTGAGTGTGTGAGGTCACTTTAGAGACCACCTTGCCAGCAGGTAGTGAAATTGGAAACATGTGCAGCCCCCTTCCTAGGTAACATTGAGAATTCACAGTTCGTCCTGTATGTTACTTAAGCATATTTAGAGATGAAACTGAAGGTTTAAAAAATGGGCTGGAAAGATCTATATCAAACTCACTGTCATCATCTGGCGACACAACGGCAGTGGCCTCATTGTGAACCTCAAAGCCTACTTTAACTTTGCCTTTATTCCTTTTTTTAAATTCAATTAATTAATTTACTTGTGGCGACAGAATCTCACTCTGTCAACGTTGCTGGAGTGTGAGTGGTGTGATCGTGCCTCACTGCAGCCTCTACTTTCCAGGCTCAAGTCATTCTCCTGCCTCACCCTCCCGAGTAGCTGCGACTACACGTGTCAGCCACCATGCCTGTATTTTTTCTAGAGATGAGATCTCACTATATTCCCCAGGCTGGTCTTGAACTCCTGCCCTCAAGCCATCCTCCTGCCCAGTTCTCCCAAACTGCTCGGATTACAGGGAGGACCCAGTGTCTGGCCTATCTTTAATGCTTTTTTTGAAAAGAACCTCCATACCTACACATATCACTTACACACTTTCAAAATATGTAGAAAAGAAAAAAAGTTTCAAAATACATATGACAACNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNCGTGGTGGCTCATGCCTGTAATCCCAGCACTTTGGCAGGCTGAGGCGGGCAGATCACTTGAGGTCAGGAGTTCAGCACCAGCCTCGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCCAGGAGTGCTGGCAGGTGCCTGTAATCCGAGCTACTTGGGAAGCTGAGGCAGGAAAATAGCTTGAACCCGGGAGGCGGAGGTTGCAGTGAGCTGAGATTGAGCCATTGTATTCCAGCCTGGGCAACAAAGTGAGATTCCATCTCAAAAAAAAAAAAAAAAAAAAAAAAAACAAAGAAAGAAAAGAAAAAGAAAAGGACTTCTTGGAGGGCAAAGTTTGAGGGAAGAGTTAGCTAGCTAGAGACCTTCCAAACTGTGCTCAGGCATTTCGATTTTACCCTGTGGGTGATAGGGAACTATTGAAAGTTTTCATTTTTTTCTTTTTGGAGACAGAGTCTTGCTCTGTTGCTTCAGGCAGGAGTGCAGTGAGCCATAGTGGCTCATTGCAGCCTGGACCCCCTGTGCTCAAGCAATCCTCCCACCTCAGCCTCCAGAGTAGCTGGGACTACAGGTCCATGGCACCACCCCCAGCTAATGTTTTGTTTTTAATTTTTTATAAAGATAGGGTCTCACTTTGTTGTCCAGGCTTAAAACTCCTGGCTTTAAGCGATCCTCCCATCTTGACCTCCCAAAGTGTTGGAATTACAGGAATGAGCCATCATGCTCGGCTCTATGGAAGGTTTTGAGGTGGCGCAGGGATGACATTACAGTCATGTCCCTTTCCCAGAGAGATTTGTCCAGAGGAAGGGTGACCAGCCTGGAGTCTCTTTGGAATGTTCTAGGTAATGTAGCAGAGATTGTGTCAGTTACCCTCTGGTGGGATGCTTGGCTTTTCCCATTTTTTCAAAAGGAAATGGGAAAAGGAAAAGGTCCTCTGTATGGAAAGTCCCCAGGAATTTATAGGAGAGTGGCTAACGAAGACAGAGTTCCCTTCCGCCATTTATTCTGACTGACTTTCTTCCATACTTTTAGTCCCACTTAGGTCATGATTCATCCCACTGGGCCAGCAGCAGCATTGGGATCACGTCAGCCAATCTTCGCACTTAGAGATTTTGAAGAGAGATATCTCCTATCCATGTGGTACATTGCTTTTCACAAAACAAAAGAGTTCATTTTCTCGGTGAAAAGCCCTGGCCAGACCCAGCCGGTGGAGACCAGTAGCTTCCTCTGGCAGGATGGGCTTCCTATGGTCATTGCAGTCCCTCCCCATTTATAAGCCTGCCTTCCCTGACAACACATGGGACAGATGCCCCCCAGAAGCATGCCCTCTGGAAAGGGAGAGGAGCAGGAGGGGGCTTCAGGCATGCTGGGCCTGGGGGGCCACCCCCCTGGCCTTTGATAAGTTCCTGGCTGGTATGAGCCATCTTCTTTCCTCTCCCCAGGCCTTGCAAAGGCCATATCTCTTCCTTTTCATGACTCTGGAAATTCCATACATACTTTCTGCATTAGGAAGACATTCTCTGCATGCTGATCTCGTTAAAAAGGAAAAGCCAAGGAGCATCCTGCACCTCCCTCCTGTAAGCGAGCTTTGCAAATGGTAAACTAGATCCTGAAAGGCAACCACTTAAAAGCTTTTAATGGCTTCCCATTATTAGCTTGAGTGCCTGGTGCGTCAGACGCTCTCAGTGACCGTGTATTGAATTGCTGAATGCATCGTCGCCCTGGGCGAGGAATCTGGCCCTCACTGTCCCAACCCTGAGTGCCTTTGCCCTGTGGAGGAAAGCACTGCCTTGGGGTCAGAAATAAGGATTGGCAGGATTGCCTGGGGTTAGAAATAGTGATCATGGGATCAGAGGCAGCAGGTGAATGTGGGGTGTGAATATTTTTGAAGGCTTGGAATGAAATGATTCTTCCAGACTTTACAGGATTTGTGTCTGCAGATTCTTCTCTAACGTTTCTGTCTCACATAGTGAGAGAATCAGCCAGCCAGGGAAATGGGACAGGATTTTGTCTCTTTCCCCATTTCCTCTTCTAATGAACTCCTACCTATGCTTTATGACTGCATTAAGGGGTCACCTCCTCCAGGAAGCATTCCCTCATCTCCTTACGCTGGTTCTGAGTGTGTCGTTCCTGCTTGATCCCCTCCCAGCACCATGTGTGTGAGTTCTCACAGCTCACACCCCATAGTATTACTATGTTGTTTCTACAGTGGGTTCCTGTCAGGGGTTCCAAACTTAGCTGTTTAGGAGGATGAGTAGATTGTACAACCACACCAGGCGGGCCTGATCAAATACAGTAAGAAGTGTCCGGATTGGCAAACCAGCGGGTCCCTCTTCTAGATGTTATCAGAGAGATACTGTTAGAGAGAGGTTGCTAGATGTTAATAGAGGCTGCTGTTACATTCCAGCTCCCTCCTCCCCTCGTCCCTTTTCTCTCCTCATCCCAAAAGATAGACCCAGTGTTGCCAGAGCTTCCACTTTTAAAAGAGAAGCCTTTTAAAATATAAACTCTCCTGATTTTTAAATGTTTTCAGTTAAGTTTTTAAAGGAACATTCATAGGCCAAACCAAATACCTGTGGGCCGTATGTGGCCCCCGGGGCCAGCAGTTTGCAGCTCCTTGGTTATAGGTCCCTCTAACCCATTCCACAAGCTCCCTCAGGCATTTCATGTCTTTCCTTTCCATTCCCCCTGGGCCTAGCAGGGAGCTGGCATGTCACAGTGGGTGCTCCCTAATTATTGGTTATTGACTTGAATGCTAGACTGAGCAAGCACCTCCCTGCTCACAGGGTGTTAACATTTTTCCCTCAGAACTGTTTGTATGTAATGCTATTCTGAATTGCTTCAGTTCCTTACATACTTTAGTGATAGTCTGTATCTGCCTGGAAAAGTCATCATTCCTTAGATTCTAGACAACTCTGTTCTTCTGTTCTTTTCCTTTTTCCTTTCTCTCTCCGTCCCCTCAACATATGTTTTTGTTTTTTGTTTTTTGCCAGTTCTTTTGTATCTGGCCGGTTAACACACGGCTTCATAACATCGGGTCCGCTGTTATTAACCAACAGTGGTTTCCGCTAGCTCACTGACTTTGCCCTCTCTGCTGGTAACCCATTCCTGATTTCCATCAGCGTAACAAGCATCATTTTCAGATTTACCTTCATTTGCAGTGAACAATTATAGCAAAATTGCTTAAAGAAATGAACCTTCAGGTGTGGCGGCTCGTGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGAGGATCACTTCACCCCACGAGGTCTCTAGGCTGCAGTAAGCTCTAGTTGCACCACTGCACTCCAGCCTGCGTGACAGGGTGAGACATCGTCTCAAAAGAAAAGAAAGGAAAAGAAAAGAAAAGAAAAGGAGGGGAGGAGAGGGGAGGGGAGGGGAAGAGGGAGAGAGGCAGGGAGGGAGGGACGGAGGAAGGAGGAAAGGCAGGAAGGCAGGAAGGCAGGAAGGAAGGAAGGCAGGAAGGCAGGAAGGCAGGAAGGCAGGAAGGAAGGAAGGAAGGAAGAGAATGAAAGGCTGGGCGTGGTAGCTCTTGCCTGTTGTAGTCCTGGCACTTTGGGAGGCTGAGATGGGAGGAATTGGAAACCAGCCTGCGCAACATAATGAGACTTCATCTCTACAAAACAAATTTTTTTTTAATTAGCCACTCCCATGCACCTGTGGTCCCAGGAGGCCAAACCTGGAGGATTGCTTGAGGATGGGAAGTTGAGGCTGCAGTGACCTATGTTCCCACCACTGTACTCCAGCCAGAGTCACAGAACAAGACCTTGTCAAAAAAAGAAAAGAAAGAAAAGGAGAGAGCGACGGAACGAAGGAACAAAAAAAAGAAGGAAACGGACACAGGAAGGAAGGAAGGAAGGGAAGGGAAGGGAAGGAACGCAGCGAAGCGACGAAGGTAGGAAAATGCAACGAACGGAGGGAAGGAGGGAAGAAAAGAAAGAAGGAAGGAAAAAACCGGTCGGCTATCTTGACGAAAAAAGTCTCAGTCCACTCCATTTTGTGCAGCATTTCCCGTCTTGTTATCTTTCTGGAAAAACTCAGTAAGTCTCTGCCTGGGAATTATAGAAGCTTAATATGCACTTGTAACTGTGTCAGGCTCTCACAGGGAACAAACAAGAGGAACTATAGATTTTTATACTCTCCAAGAGCCCACTCCATGCATTTACGAGGCACAGAGTCAGAGAAAGAGCATTGACAATGATAATATAGCATTAATATAGGTACAATCTGGAGTAATGTTATCTAGTACTACTAATACCGATATTAAAATGCCATTATATACATATTAAGCCCTCACTTCGTGCCGGTTTGAACTTTTCCTGTATTAATTCATGTGAATCAATTTTCACACTCTCTCTCAAAAAAAATATATCTATATAATATATACAAATATATATAATATATACAAATATATATAATATACAAATATATATATATAATATATACAAATATATAATATACAAATATATATAATATATACAAATATATATATATAATATATAGATGTCATCCTCATCGGAAGACTCCGGCAGGAGACGAGCAGTTTAATCCCAGGATCCCATCCACAGCAAACTTCTAGGTCTCTTACCCAGTGTCTTCTCCTGCTCTCTCGCTCTCATTTCTGAACTAACAAAAGTCTGCAAACATCATCTGCTCTCCTGGTTGTATTTGTAAATGCCTCCCCTAGACCCAGCTCTACTTTAGGCCACGTCAGTGACAGTGACCACATCACTCAGGCATTCTCCTACTGTCCCTGACCCATCTCCGCTTTTCTCTCCTCCCACTCTAATAACACACCGTCTCCCTTCAACCTCAGCCCTGCTGCCAAGTACCTGTCTCAGCTTCAGAGCCTGGTGCCTCAGTTCCCTCATCTGTAAAATGGGAATACAAATGGTCCCTGTCTGTTTGGCTATTCAACAAAATTAACTCAGTTCCTGCACACCTCACCTCTCGCTCCTTCAACAAAAACATGGTCACCCTCAAACCAAACGTGAACACCAGCCTCCTCACGCAAACCACATCCAAACGAGAGGCAGACCCAGCCTCCACTGCAATTGCACGATCTCGGCTCACTGCACCCTCTGCCTTCCAGGTTCAAGCAATTCTTCTGCCTCAGCCTTCTGAGTAGCTGGGATTACAGGCACCTGCTGCCAAGTCTGGCTAATTTTTCTATTTTTAATAGAGACGGGGTTTCGCTATCTTGGCCAGGCTGGTCTCGAACTCCTGATCTCACGTGATCCACCCGCCTTGACCTCCCAAAGTGCTGGGATTACAGGCATGAACCACCGCCCCCGGCCGCAGATGGGAAATTATTTTTGCACTTTCAGTTGTCCTAAATCTAGACTTTTCCTTTATCCACACAGCTGGTGAAAGTCGACGTGAGAATAGACAGATTTCCTGGTGGGCAAGACCTCCATCCTCCTTCTCCACCCCCTTCCTCATTATTCCCAAGAAAAGAGCTTCTGGGTTTCTGGGAGAGGCTGAGCAGGTGGAGACACCTGGGCCATATCTGGGTCTCTCCAGAATCCAGGAGCCTGCCTGACGCGTCAGCCGGGGAGGGTTTCTGTGTGAAGTCGGCTTGAGTGAGCCAGCCTTTCATGCATCCTTGTCTTTATTTCTTCCCCAGCTCAGGAGGGGCTGAGTTGTGTCTTAATGAGCAGTTCCAGCTGCATGCTGGGCATCTCCTAATTTACTCTCATTTATTTAGCTCCTGCTGCATGCTGGGCAATGCTCTAAGTGCTCTGCAGGTTTTGGCTAATTTAATCTCCCTAGCAAACCCTTTGAGGGGACTGACAGGATGACCATCCTCATTTTACAGATGTCGGGATTGAGGCACAGACAGTTTATTTTTAATTTTTATGTGTAAAATGTTTTTACTGTGGTAAAATTTACATAATAAAATTTGCCATTGTAACCATTTCTAACTGTACAATTCACTCCCATTAAGGCCATTGGTATTGTTGTCTAACCATCACCGCTAATCTAACCATCTCCGGAACATTTTTCATCATTCCAAACTGAAACTCTGCACTCATTAAACACTTACTCTCCTCTCCCCCTCCCCTCATCCCCTGGTATCCACAGTTTCTATGAATCTAACTACCCTAAGCATCCGTATAGGTGGAATCATAGTATTCATCCTTTTGTGACTGGCTCATTACACTTGGTGTAAACTTTTTTTTATTTTTTATTTTTTTTTGAGACAGAATCTTGTTCTGTTGCCCAGGCTGGAGTGCAGTGGCACAATTTCAGCTCACCACAACCTCTCCCTCCCAATTCAAGAGATTCTCCTGCCTCAGCCTCCCTAGTAGCTGGGATTATAGTCGTGCACCACCACGCGTGGCTAATTTTTGTATTTTTTAGTAGAGACGGGGCTTCGCCATGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCCACCCTCCTCGGCCTCCCTAACTGCTGGCATTACACGCATGAGCCACCGTCCCCCACCTTACTGTAATCTTTCAAAGGTATATCTCCGTTGTAGCCTGTGTCACAATTTTATGCCCTTTTAAGACTGAATGAGTTTTTAAATTCATTCCCATTTAACTCTTTGTTTTGTTGCCTGTGCTTTTGGTGTGAGGCACAGACATTTTAAGAAACTTAGCCAAGGCCATTCAACCAGAAGTGGCAGAGCCTGGATCTTGACCACATGGCTTTGCTGCTCCCAGAGTCTTGACCCTGTGCTGGGGCTGACTTCTGCTTTTACATGAGTTCTTGTCAGTGCTTTCGGCAGCTTGATCAGGTAGATGCTGCTTTTCCACTTTGCAAATATGGAAGGGAGCACCCAGCTCTCTTGGGCATGGCAGAAATTCATCAGGGGCGGAGGAGGCACAGCGTACCCACCCAAAAAATCCCAACATATTGAATCACCTTCCAATAATCTATACCATCATTTATGTTATGCTGCCCACAACATAAATGGCTAGCAAATAATTTGGATGCGACAGAATTGGTGAATGAATTTAATCTAGCTTCAACCTCAACACCATTATACACTATTAATACCTACAAAATTATAGATGTAAGGCTGGGTGTGGTGGCTCATGCCTGTAATTCCAGCACTTTGGGAGGCCAAGGTGGGCAGATAATGAGTTCAGGAGTTCGAGACCAGCCTCGCCAACATAGTGAAACCCCGTCTCTACTAAAAATACAAAAATTACCTGGGCTTGGTGGCACATGCCTGTAGTCCCAGCTACTCAGCAGGCTGAGGGAGGAGAATCTCTTGAACCCGGGAGGCGGAGGTTATGGTGAGCTGAGATCACGCCACTGCACTCCAGCCTAGGCAACAGAGTGAGACTCCGTCTCAACACAAACAAAATTATAGATGTCACCTACAGGCCAGTTGGGAGGCATATTGGTAAGTAAATACCCATGACCTCTCCACCCTGCCTACGATCCAAACTATGAACACTGATGGTTCACTCTAACTCCATATTCTTTTCACTTTTCTCCCATGCCTACCCCCTGCCCCCGAGCATTCTCCCTCATTGGTGGCCCTGATTTTCTTTTTGTTGAGATAGGATCTCACTATGTTGCCCAGGCTGGTCCCAAACTCCTGGGCTCGAGAGATCCTCTTATCTCGGCCTCTCAAAGTGTTGAGATTACAGGCGTGAGCCGCTATGCCAGGCCAACTCTTATCTTGAATGTTGATGTTTATCATGTCATCCATGAAAAAAAAAAAACCCATGCGTATTCTTTTTTTTTTCTTTTTTTTTTGAGATGGTGTTTCGCTCTTGTCACCCAGGATGGGGATGGAGTGCAATAGCATGATCTCGGCTAACTGTAACCTCCACCTCCTGGGTTCAAGCGATTCTCCTGCCTCAGTCTCCTGAGTAGCTGGGATTACGGGCACTCGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGATGAGGTTTCACCATGTTGGCCAGGCTGGTCTTGAACACCTGACCTCAGGTGATCCACCCGCCTCGGCCTCCCGTTTGTATTCTTAAATAGTGTATTGTTTCCTTTACTTCCTTTAGAGCTTTACAGAAATTCCATGCTGCCTTCAGCTTCCTTTGCCGCTCTGCATCATGTTGGTAAGTCTCTGCTGATGCCTGCTGCTGTAGCTTATTTTTCACTGTGATAATCTGTTCCATTGTGTGAACTGACCACAGTTGATTGATCTGTTCTCCAAGGACATGTGAGTTGTTCGCAGGTGTCCCCCCACCCCCTCCCGATACAAACAGTGCTGCTGTGGACATTTCATACATCTGGTTGCCTATGTCAGAATTTCCAGGGTATACAGCTAGGACGCAGTACTGCTGTTGGATTTTCCTGGGATTGTAGACTCTCAAATTTCGAATGGACTTCTATGGCCAAGTAGTTCACCTTCAGCAATCATCTCAAAACAAATGCTCTTGGTGTCATGCTTGACAGCGCTGTTCTGCAATAGGAGAGACACAGACCTGCTGGGCCTTTGCCTCATTTTATTACTTAGTTCATTATGCAATGAACTTAACATCTGTCTACCTCAGTAGTTTCCCTGTCTGTGAATTGAGTCTGTTACATATATATATATCTATTTAAATATATATATCTATTTAATATATATTAAATAATATATATTTAAATAGATATATATATATTACAGACTCAATTTAACCCTTAGGACCCCAGGAGCGGATGAATCGTAACCCAGTTCNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNCTTCCAGGCTTCCCATTTTAGACTTGAAATGTAGGCCTGTTGGGGCCTCCTCCAGTAGATGTGTGCCCTTGAGCTTGGATACCCCCCTGCCAAGATACGCCTTTCAAAAACAGCATAAACTTATCGCAACTGAATAGAAGGCGCTCCCAAGCGGTCCCACCCTGCTCCGGAAGTCTCAGTGAGGAATCAATAGCTGTTAATTCCTGTGCTGCCCCCTGCCTGACATTCCATCCACACTTGAGGCCCAGATTGTAAGAAGGGAGAGCAGGCAGGTCTCTCTTCCAGGAGAGGGACCCGGTTCATCAGCAGGATTTATTCATTCATGTATTACGTCAGGCTCAGCGCCTGGGCTTTTTATAAATGAGGGCTCTGCTGGCGTTCTGTGTTATTCAGATATTCGGTGAGAGACCACCAGAACCCACAAAAAATTGCTGACATCTGTTGGAAGGCAATCATGCATAATGGATAAGGGTGCACTCTGCAGTTCCAGCAGCATTGATTTGAATTCCCCCTCTGCCGCTTCAAAACTCTGACATCTCAGCGAGTTGCTTACCCTCTACAGCCTCCACGTCCTCATCTATAAAACTAGAAAATAAGTGGTACTCACTAGATCCTTACCTTGTTGTGAGAGTAGAATGACGTGCATGTAGAGCTTTCCCAGAGCTGCCATGTGGTACGTCCTCAATAAACGCTGGTTATTCTCTCTCTCTCTCTCACTCTGTTGCCTAGGCTGGAGTGCAGTGGCGTGATCATAGCTCACAACAGCCTCTGTCTGCCAGGCTCAAGGGATACTCCTGCCTCAGCCTCCTGAGTAGCTGCGACTTGCAGGCAAGTGCTACCCCTCCTAGCTAATTTGTTTTATTCTTAGTACAGATGGGGTCTTGCTATGTGGTCCCTGCTGGAGTGCTGGTTGCTCTCTAACTGGCTGCGAGCCCCGGGCTAGGCACACTGGTACTGGGGCTATAGCAAAATCCGTGCTCGGTAAATCATCATTGAAGGAGCAAGGGTGCTTTACAGTTGTAGAATCTCATAGTACACGTTACTTTGGTTTTTCTCTTCCCAGCTCTGGAGTCCTGGGATCCAAGTGTGAGCCCCATGTCTGCAAAATGAGGCTAGTCACTTGAATCCTCTTGGATCTTGCTTTCCTCATCTCTTAGTGAGCTTGTAGATAGCTCTGACTGTCACCAGGCTTTGCTCTGAGCACTCTGCATCTGTATTCAACCTGTATACTTAATCTTCACAACAGTTGACCTCGTTGATCCATAGTAATTTCTCGTTGTACAAACGGAGAAACTCAGGCAGAGAGATAAGTGTCTTCCCAAGCTTAACAGCTAACCAGTAGCAGGGCACGCTGGGATTTGAAAGACTCTCTATGTGTCCTAACTGGTATCCTCTCCTGTCTAGAGGTGATCTCTTCCTCCAGGGTTCCAGGTAGATTGGTTGAGATGTGCAATGCGGAAGAGCCTCGGGATAAGTCGGCTAATGACACCCTCAGGCTACCCAGCCCTCGGGAGCTCACAGCAGAGCAGTTGGGGATGCCTTGCAAGGTTACCTGTGCCAGAGTTCCTCGGGTACATATTAAATAGGTAGGACCCAATACTACTTTGCATTTTCCTCCAATCCTAGACTCTTAACATTGGAAAGGATTTCTTTGCCAAGTAATTCGCCCTCATCATTAACCTCTAAGAAATGCAGAGGTGGAATTAGAAGGTGCGTGTCTCTTTCTTTTGCACCACAGATTCTATCGAGTCTCATCTGGCAGCTTCAAGGATCATCCGCATTCTTTCATCTTCATGGAATGTCACTAGATTGAGATGATTCTAAGGGTGAGGTCAAGCATTTGGAGTTTGCAACTCTCCCTTTTGTAGAGATGCTCCCGTGGGACTTGCCCTGCACCCAGTTCAGCTTGCTTGCCATCCATCTGCTGAGCCTGGAAGAGAAGTATGGGTTCAAGGCCAGCGGTCCAGCACTCCCACAGACCTGATCTGTAATAGCGAACCGTTGCCTCTGTGTGGGTTGGGAGTTTAATCAGCAAGAGTGGATTAGCAGCAGGCTCATTCTGTTTACTCCAGTAGGTCACGGGGCCAAGGGCAAACATACACCCCTCCCAGCCCAGAAACTGATAGCTGCAAAGTTGCACACCCTTCTCCCCAAATTGACAAATATCGTTTTCATTGTTGGAGTAATAAATTATGCTTTTTAACGATAAAAATGTTGCCCAGCTGTTGAGTGGTTTAAACTTCCAGATGTTCCTCTGCTCAGTAATCAGAGCAGGATGCATGATGGGATCTCTTTAAAAGTTGATCAACAGAATGGTTCATTAAATTTCAACAATGTGCCTCGAATGCCAACGCCACGTCTACCATCTCCCTCCACCCAAGGAGGTACACATTTCCTAGCCTGCTTGCGTCAAGAATTAGCAAGCAGTAACTGAAGACCAGTTACTGGTCAGGCAGGGAAGCCCAAGTTCTGGCCCCTGCTGACTGTGTGACTTTGGGCTGAGCAGTTGGCCTCTCTGAGTCTTAGGTTTTGTTTTTTTTTTTTCTTTTGTGTTTTTGAGATAGAGTCTCGCTTTGTCGCCCAGGCTGGAATGCAGTGGCGCGATCTTGGCTCACTGCAACCTCTGCCTCCCAGGTTCAAGTGGTTCTCATGCTTCAGCCTCCCGAGTAGCTGGATTACAGACATGCACCACCATGCCTAACTAATTTTTGTATTTTTAGTAGAGTTGGGGTTTTACCATGTTGGCCACGCTCCTCTTAAAGTCCTGGCCTCAAGTGATCCGCCCGCCTTCGTCTCCCAAAGTGTTGGGATTACAGACATGAGCCACTGCCCCGAGCCTGAGCCTCAGTTTCTCATACTTGCAACTCGGAGCATGTTTTGAGAGCTAGAGAAAGTATTGTTGTCTTGTGTAACATGAAAAAAGCTGTGCGGATACTAGCTAAGATCAATGAAAGGTTATCAAACTCAATCTGATGGTGAAAGAAGATACAGAGATCAAGCCCGTCCGCATTTTTAACGTGGGGACACTGAGCCCCAGGAAACTTGGGCCTTCTTCAAGTAGTACCTACGCCTCTGCTCTCCCATATGGTACCCGCTAGCCACTAGCCGCATGTGGCTATTGAGCAGTCGAAATGTGCGAAAATTCAAATTAAAATATGTTGTATATGTAAATTGCACAATGGATTATAAGACTCAGTTTAAAAAAAAGAAAAAATTCATAACAACTTTTGAAATATTGATTACATGTTGAGATGATAAGATTTCGATATACTAAGTTAAATAAAACATTAAAAATGAATTTCACCTTTGGTTTCTGCTTAGTATTTTTTAATGTAGCAACTAGAAAATTAAAAATTACTGCCGGGTGCGGTGGCTCACGCCTCTAATCCCACCACTTTGGGAGGCTGAGGTGGGCTGATCACGAGGTCAGAAGATCGAGACCATCCTGGCTAACACGGTGAAACCTCATCTCTACTAAAAATACACAAAAAATTAGCTGGGCATGGTGGTCGGCGCCTGTAGTCCCAGCTACTGCCGACGCTGAGGCAGGAGAATGGCGTGAATCCGGGAGGCGGAGCTTGCAGTGAGCTGAGATCGCACCACTGAACTCCAGCCTGGGCGACAGAGGGTCTCTGTCTCAAAAAAAAAAAGAAAGAAAATTAACAATTACATGTGTAGTTTGCATTATATTTCCACTGGGCAGTGCTATGCTAAACTGTGACACAAACGGTGGACTTTAGAGTTGTGCAGGGTACAATCTGCACGGCCATATGTGGCAGGCCTACCAGGTGTGGATGAGGCTGTCTGGGTTCGAATCCTGGCTCTACCAGTAATCAGTTGTGTGGTATTGACTAAATTGTTTAAACTCTCAGAGCTTCAGTTGTTCTATCTGTAAAATGAGTATTGCAATAGTGCATGCTTCATAGAGCTGTTGTAAGGATTAAATGAATTAGTGCATATAAAGTGCCTAGAATAGTGTCTGGCCCGTTTTAAGAGCTCAGTGAGTCTTGGTTGTTGTAGTTGTTACTTTAGTGGTTGTTTTTTAGAACCTGAGGACACAAGGATGGAAAGACTCAGTCTGTCTGTGGCAAACCACGAAACGAAAGATTAAACAATTCAATGCAGGCTCGCTCCAGTGCGTCACACTTGTAATCCCACCACTTTGGGAGGCCAAGACGAGCGGATAGTTGAGATCAGAAGTTCTTGACCAGCCTGGCCACCATGGTGAAATCCCATATCTACTAAAAATACAAAAATTAGCCAGACGTAGTGGCGAGTGCCTGTAGTCCCAGCTACTCGGGAGACTGAGGCACAAGAATTGCTTGAACCTGGGAGGTGGAGGTTGCAGTGAGCTGACATCACCCTACTGCACTCCACCCTGGCCGACAGAGCACGACTCTGTCTCAGAAAACAAAGAAAGAAAAAATAAATTCAATGCAGTCATTATTAGAGGGGTAAGTCCATCGGGACAAATCAGGGGGCATTCCCACTGAGGCAGGACTTGAGATGAATCTCGGAAGCAGAAATGCTGAGCTTGTTGGGCTGGCCAGAGATAAGAAGGACATTGTGGGCGGGAGAAACAGCACCTACAGGGCTGAGATGGATGAAAGCTCAGTTCAGTCTGGGAACTGCAGAAACTCAGTTTGCCTGAGCAAACTGCAATGTGGCAAGTGGGAAATGAACCCAAGCTAAAAGAGGACAGCACCTGGGTGTAAATTTTGTCCTGTAACCCATGGAGAGCCAAGAAGGATTTTGAGCCAGGGAGTGACATGATTGGATTTCATGATCAGATCATTCTAACTGCTTTGAGGAGGTTGTCTTGGAACGAAAGCAAGAGTCTTTGGCAAGAAGATCAAGAGAAGAAAGATTGCTATTTCCAAAGCTCAAGTAGTGTATTTTTCATTGTTGTTGTTAAAGTTCAAAAGTCTTTATATTGAAAGTGGCACGTATGCTATGATCTCACACCTGTAATCCCTTCCCAGTTTATCTGCATGAGAAAAGCGCTTGGAATGGTGCATATCTAAAGGTGGTTTCTGCTCAATGGGGATGTGGATTCTTGTGTCAGGTTGTTGGGGAGGCTTTAGGCTCTGGCTGCCAGCCCATCCCACTGACACCCAACTTCATATGGATGCAGAGCTTTTTAACCATATCAAAGAGAAGGATACGAGCTTAAAATATGAAACTCCTGCTTTTGATATGCTTAAATTCTGGGTCTGATATCTTTTTGAAAGAATTAGGTTTTTAATTGAAATAGCACATGCATATATTTAACATCAAATGGGTAAGGCTTTTATGCAAAATCCAGATTCCCCTGCCCTTTTTCTGCCTGTCCTTAGCCCTGTTTCCCAGAGTGAATCAGGGACAGGTCAGTACCTCTAAAGAATAAGCTCATGTTGCTCCTTGTCTGTTGACTTAGACTTCTGGACCCTCAGCAATGTCCCGGGACTCACACTGGGGGAGGCAGGGAGACCAGCATGCCCCCTCTTGCCACTTGTACTTCCCATTTTCCCCCTGCCAAGGTGTGCAACATTTATACTCCCACGCCCACACTTAACACTCCTGTCCTTTATCTGCAAGGTTAATTCCAACAATTGATAAATGGATGAACAGTGTTTACATTAAGAGGCTTGTCAATGGCCTTCACTGCCCGTCGAAGCAGTCGGCTTTGATCACATGTCCTTTGTGTTCAGCTCTCTCTTTGCCCTCAGCTTTCTAATCGCCCTTTAAGGGGCTATCTGACGCTGGGTGAGGTGGCTCACGCCTGTAATCCCAGCAGTTCAGGAGGCTGAGGCGGGAGGATCTCTTGAGCCCAGCAGTTCAACACTAACCTGGGCAACAAAGCGAGAGCCTGTCTCTACAAAACATTAAAAAATTAGCCATACATGGTGGAGTGCGCCTGTGGTCCTAGCTGAGGTGAGAGGATTGCTCGAGCCCAGGAGTTTGAGGCTGCAGTGAGCTGTAATTCCACCACTCCATTCCACCCTGCGTGACAGAGTGAGACCCTATCTCAAAAAAAAGGAACTATCTGGCTTCATCCTAAGAGTAGTTGCATTTTAAACTCTCAGTCAGCTTCTTTTACTGTAAAATGGGAATAATAATTAACAGTCTAAATTCCTAAAGTGATTATGAAGGCTGAACAGGTGATGCCTGTTCCTCAGGCCCCTCCCTTGGGGCCCCTTCAGCCCCATGTGTCCCAGGCTAATCTCAAACTCCTGGCCTCAAGTGATCTGCCTACTTTGGCCTCCCCAAGTGTTGGGATTACAGACACGAGCCACCACTCCCAGCCAGCTTGCTATTAAATTTTACCTTTTTATCCAGGAGCGTGGGTCATCATTTCTTTCAAATAATGCTTCTATTTATGAGATTTTTCTTTGTAGAAAATGTGGGAAATGTTAAGAGTATAAGGAACAAAATAAGTCGTGTTAACGCAATTGCTGCATTTTTCTTTTTTTCTTTGCATATTTCTTTTAAACTTGAGATCATGTAATGTCAACAAGTTTATTGGATTTTTCTCCTAATGTAGTATTAGTATTTCCATGTGTTGTAAAGAGCAAGCTTTTAGGTATCATTTTTAATGCAATATAATGTTGTAACATCCTATTGCAATGACAGCTTGTCTTTCTCCCAATTTTATCTGCACTATTAGGTATTAAGAATATTTAATGTGGCCGGGCATGAAGGCTCCTGCCTGTAATCCCACCACTTTGGGACGCCCAGGTGGGTGGAACACTTGAGGTCAGGAGTTCGAGACCAGCTTGGGCAACATGGTGAAACCGCATCTCCACTCAAAATACAAAAATTAGCTGGGTGTGGTGATGCATGCCTCTAATCCCAGCTACTCGGAAGGCTAAGGCTGGAAAATCATTTGAACCCAGGAGGTGGAGGTTGCAGTGAGTCGAGATCATGCACTGCACTTCAGCCTGGGTAACAGAGCCAAACACTAGCTAAAAAAAAAAAAAAAAAAAAAAAGAACATTGTGTATTTTCCTCTTTTAAATAATGTTGAGATGAGTGTTTTGGTGTATATGTCTGTGCATGTGTGCACATATGTGTGCAGAAACCTATAGGATAGATTTCTGCAAGAATTATCAAGTCAAAGGTTCTAGACATTTTTAAGGCTCTCAATGCATGTTGTTCAGTTGTTTCCCCATTTGGTTACACCAAGTTACAGTCACAAAATTACACCAAATATTTTTTCCTCCATGGAGTTGCTTTCTCATGAAATTGGGTTTCTGACCCCACGAAGACTTCCGTCTTGTTGAGGTGAAGGGGATAATTCTTCAGCATTTGTCACTATTTTTCACTATCATTTTGAGTTTGATTTAAATAGCACAGTTTGCTGCGTGGAAAATGAGAGTAGCTTTGAAGGGGCACAGCTTTGAAGGGCACACAGTACATGATCACATCTACTTCAGAACTCTGGCTGCTACGTCGGGTACGACCATGTTCCATTTTCAGCATGCTTTACTGCAAATCAAAAGCATGGGATCCCAATCCAAAACCAAAGGGCTTAGGTTCTGCATCTGACATATCTGGCTAGCTGTATGTTCCTTGCCGCCTCACTCAACCTTGCTCAGTACATACCTTCTTCATATGGCGTGCATCTCTTCCTCAGCTATATGGGTGTCCTCGAAAATGCTGAGCATAAGAAAACTCCATTTCTATCCTCTTTATTTATTTATTATTTATTTATTTTTTGAGATGGGGTCTTACTCTGTTGCCCAACCTGGAGTGCACTCCCACAATCATGGTTCATTGCAGCCTCAAATTCCTGGGCTCAATGGATTCTCTTGTCTTAGCCTCCTCACTTGCTGGGACTACACCAGTGTGCCACCATGCCCAGCTTTTTTTTTTTTTTTTTTTTTTTTCATACTAGAGATCAGGTCTTCTTATCTTGCCCAGGCCACTTTCGAACTCCTTGGCTCAAACAATTCCCCCTCCTCTGCCTCCCAAACTGCTGGGATTATACGCATGAGCTACCGCTACACCCAGCCTATCCTGTTTACCTACAACTTGCCAGTAACCTTCCCCAAATTGCTTCGCCTCAGGATCTTCCTTTTGTTTTCTCTAAAATGGGAATAATAATAATAATAATAGTCCCTAATTCCTAACGGGATTCCCAAGGTTCAACAAAGTGCTTCCGCTAGATTGCTTGACCTGGTGCCTAATCCTGGTGATTTCTCGTAAAAATCAGTTGTTCCCACTAGTGGAGTCCACCAGACCTGATCATTCCCCAGCCTTCAGTTCACCCAACCTCCACTTTAGTTCTTCAGGCTGGTTGTATATGGCTCCCTAGATTCATCGTTTGGAATCTTCACAGTCAGAAGGCACCCATCCAAGTTTGCCACTCAATGGATGACAAAGTAAGGNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN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AACCTACAGAATCGGAGAAAATTTTTGCAATCTATCCATCTGACCAATGGCTAATATTCAGAATCTACAAAGAACTTAAATTTACAGGGGAAAAAACAAACAAACAAACAAACAAAAACCCCATCAAAAAGTGGGCAAAGGATGTGAACAGACACTTCTCAAAAGAAGACATTTATATGGCCAACAAACAAATGAAAAACAGAAAACAAAAAACAACTCATCATTACTGCTCATTACACAAATGCAATCAAAACCACAATGAGATACCATCTCATGCCACTTAGAATGGTGATCATTAAAAAGTCAGGGAACAACAGATGCTGGAGAGGATGTGGAGAAATAGGGACGCTTTTACACTGTTGGTGGGAATGTAAATTAGTTCAACCATTGTGGAAGACAGTCGGGTGATTCCTCAACGATCTAGAACCAGAAATACCATTTGACCCAGCAATCCAATTACTGGGTATATACCCAAAAGATTATAAATCATTCTACTATAAACACACATGCACATATATGTTTATAGCAGCACTTTTTACAATAACAAAGACCTGGAACCAACCCAAATGCCCATCACTGATAGACTGGATAAAGAAAATGTGGCACATATACACCATGGAATACTATGCAGCCATAAAAAAGAATGCATTCATGTCCTTTGCAGGGACTTGGATGAAGCTGCAAACCATCATTCTCAGCAAATTAACACAGGAACGAAAAACCAAACACAGCATGTTCTCATTCAGAAGTGGGAGTTGAACAATGAGAACATATGGACACAGGGAGGGGAACATCACACACTGGGGCCTGTTGGGGGATGGGGGGCAAGGGGAGCGATGGCATTAGGAGAAATACCCAGTGCATGCGGGGCTTAAAACCTAGAAGATGGGTTGATGGGTGCAGCAAACCACCATGCCACACGCATATCTATGTAACAAACCTGCGTCTTCTGTACATGTATCCCACAACTTAAAGTACAAACAAACAAACAAAAAACCTCCACAAAAACCCTATCTCCAGGCTTCCCATTGTATCTCCTGACTTTTTTGAAATCCTGAGCAGCCTGTTCCTGTTGATCGAGTGAATGAGCATTCTCTGAAATTGCAGTGAGTGACTTCTCCATCACTAGAGGTAGTCAAGAAGAGGTTGCAATCACACACAATTGGATGAGGTAAATAGAATTCATTTGTTAGATAGACTATGCAGGCCTAAGATTGTTTAGTATTCACGGAGTTATTTTGTGAACACTAGTGTCTTCCAGCCTCATCAAGTGGTCCCTCCCTCTGTAGCCCCACATCCTGGTCTTTGATCAGTTCCCTGACACCCTTCCCTGGGCACCACAGGACCTTTGCACTTGCTGGTCCCACATCCTAGAATGCTTTTTCCCCACCTTGTTGAAAAGCTGATTCTCATCCTAACTTCAATATCACCTCCTCAGACCACCCCTTCTAATAGACTCATTCCCTAACCTCCATTTCTCATCACTGGATGCTGCTGAATTTCACTGTGGCACCAGTCATAGTCTGTAAAAAAAATTTATTAAATTATTTGGCTCTTTGATTTTGGTGTGACTCCTCCCCTAGAGAAAAGAAACTGACTTTGTCCTTGAACTCTGTCTTGTCTGACACTCAGTGGGTGGTTCATACATATTCTTTTTTTAAAATTAATTTTAATTTTTATTTTACATTCCGAGGTACATGTGCAGGATGTGCAGATTTGTTGCATAGGTAAACGTGTGCCATGGTGGTTTGCTGCACCTATCAACCCATCACCTAGTTATTAAGCCCAGCATGCATTAGCTATTTTTTCTATGAAAGGTGAGCAAATGCTTGTATACAGCCTGCACAGGGTTACGTCAAGGCTGAACCATGTACTCTAAATTTTGGACTGACTGCAGTGAAGCCCCTCCATGGTGGAAGAAAATGGAATGTCCTTGTTGGAGCTGGCCAGAACTGGGCAGATCCAGAGGCTGGAGGTAATCCCAATAACTCTGACTGCTAATAATAAAATAAGAACGTAAAACACTGCTTACAGTGTGTTACAGGCACTGCTTTAAGTGCATTACCTCATTTAGTTTCCACAGTTGTCTCCATGTTACAGAGGAGAGGACTGAGGCACAGAGTATTACAATAAGAAACTTGGCCCACAGTCAGCGAGCAAGAAAGCCTAGATTCATACCTGGGCATATGGCTTCAGAGTCCACACGCTTGGCGCCTGCACTGCACCGAGAGGGGCTGCTGGGCCGGGAGTCCCCCACCTGCTCTCTGTTTTCAAACTCCCCATTTCACACCCATGCCAGGTGTGATGAAATCCTCTAGGTGATGGGCAGTGGACATGAGTGGTTCTGGTTACAGTTGGACTTCACTGGCCTGTCCCACACCTGAGGATATGGATTCTAGCCCATGGGACCATAAGCCAGGCCCCCTGAGGGTCTGTTATTTGTCTGGGAAGTGGCAGCGCTCTTTGGAATCTTGTTCATGACTGACAAACACCCCCACGCCCCTTCAGCCATAATTATCACCTAGTCCCCACAGAAGCGCCATGCGTCCGCTGACTGTAGAGATAGACGCTTGCGTCTCTGGCTGGGAACACCACATGCAAGAGAAGAGGCCATGGGCTCGCCTTCCATCCAGCTGAAGTCTTTCTGGCCGGGCTGCAGGCTTCATGCAACACCTTTCAACCTGTAAAAGGAAAAAAGAAGGCCGGGGGTGGGCCTCAGCTGCTGCCACTGGCATTGTATCACTGAAGCGTTTTTTGTTGTTGTTTTTTTTTTTTTGAATACCGGAAATTAAGGGGAAATTCGGAAACCTCATAATGCCTTCATGAACCATTGCACTTGGAAAATGTACTTTTGAAAAATTCCCTTGATTTATTGTTTTTCGGAGGCTGTAGATAACATTAGAGTATATTATTCCTATATAATTTCCTGAGTTTTCTATGTCAATTACTTTGTTTTATTAAAGAGAAAAAAGGAACTAATATTGATTGAGGCCCTCCTGTGTGCCAGGCTAAANNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNTTGCAAGCCTATCGACACATACTGGTAATCGAACCTGTGCTCACAATTGTTGGGAATCTCTAGTTTAAAGCTTTGTCATTTGGAGGAATATCAAGTAAACCCTATGGGGTCAAAAACAAGGTCTAGCCAGGTGCGGTGGTTCATGCCTGTAATTCCAGCATTTTGGGAGGCTGAGGCGAGTGGATTACCTGACGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCCGTTTCTACTAAAAATACAAAACTTAGCTGCCTCTGCTGGCAGGCACCTCTAATCCCAGCTACTCACCAACCTCAAACAGGAGAATCACTTCAACTCGGGAGGTGGAAGTTTCAGTCAGTCGAGATGGTGCCACTGGACTCCAACCTGGTCAACAGAGTGAGCCTGACTCTGATGATAGTAATAAATAATAATGGTAGCTTCTATTTATTGTTTACTACTATCTCCCAGACACTATTCTAGCTGCTTTTCATCAATTAGCTCATTTCATCTTCCTTATAACCCTATGTTCTAAGTACAGTCATGTACCACATAATGATGTGTGGATCAGCAATGGACCGTATATACAACCGTGCCCCTATGACATTATAATACAGTATTTTTACTGTACTTCTTCTATGTTTAGATATGATTAGATACACAAATGCTCACCATTGTATTAAGTTGACTCCGATGTTCAGTACAGTAACATCCCATTCAGGACTGCACCCTAGAACCACTACGCTGTACCATATACTCCACATGTGTAGTGAGTACCCTGTCATCTAGTTTTGTACAAACTCCCTCTGTAATGTTCGCACAACGAAATTGCCTAACGCCGCATTTCTCAGAATGTATCTCTACCCTTAAGCAACGTGTGACTGTCCTATTATCATCACCCCATTTTACAGATGAAGGAGCTCTGCCAAGAAATTGACTAACTTCCCCCAACGTCACCCATATAATAAAACGCGCGCTGCGTGCAGTGGCTCGTGCCTCTAATTCCAGCACTTTCGGAGTCCAAGCGGAATAGGATCACTTCACCAGACCACTTTGACACCACCCTGGGCAACAGAGGCAGACCCTACCTCTACCAAAATTATAAAAAAATTAGCCGGGCATGGTGGCATAGACTTGTGGTCCCAGCTGCCCAGAAGGCTGAAGTGGAAGGATGGCTTGAGCCTGGGAGGTCAAGCCTGCAGTGAGCCGTGATTGTGCCACTGCACTCCAGCCTGGGTGAGAGAGTGAGATCCTATCTCAAAAAAAAAAAATAAAAAAAAAATGAAAAAAAAAATAAAAAAAAATAAATAAAATAATTAAAAAAAGAGCTGGGACTTCAAGCCAGATAATAAGCCAGGCAGAGGGCATACGAAACACCCAGATGGGTCATGAGCCCCTGCATCAGTCAGGGTCTAATCGCTCAGCTGAGGAAGGGAGGTTTAAGGAAGAGACTGTGGACAGAGGTGTTAGGGAAGGTGTCAGAGAAGGTTAAGGAGCCAACATGGATCATCGGGGTGCTACACTCTTCCCAGGGCTGGGGAGGATTGGCTGCAGTGTGGGGTACCCAGCCGCTGCCATGTGGAGAGGGACCTGTCACTCCTGCTGTGAACTCTCCCTTCTTCTCCCCTCTGACCTCCTGCTGGTGCCTCCCATTGGCTAAACACAGTTGATCGCCAGTCCACTGGGCAGCTGTTCTTGGAGCCCACACGCATCTGCTTCTTGGCACAGAGCAGACAATGGATTGAGTCGGGAGGGAGGGGAACTAGAGAATACCCAAGTCCCAATGGCTGGAGAGGAGTCACCAGCTAAACGGCCTAGAAGGTCAAGTCAGAGACGCCGCCGTCCACACTACACAGGGCCTTTGGCTTTCTTCGGAAGGAGCAGGAAGCCAGTGGAGGGTTTGAGCAGATGTGTGCATCACGGCCACTGCCATCAGGAGAACGTCTTTCTCTATGCTAGGTGTGAACAGTCACCCCTTCCTCTCCCTTTCTCAGGATGAGTGCTGAGGAGGAAAAGGCCCTTTCCTCCAATGTCTTCAGAGGAGACGTCTGCCCAGTCCAGACTACGTGCCTCATGCCAGCCAGCCTGTAAATGACAGGAAAGAGAAAGGAGCAGTGTCTCAAAAGAGGATATTCTCGAACGTTTGATAATCAGAGCCCATTGTAAAGTCATGTTTTGAGTTACAGCATTTAAATCTTTGTTCCAGTGGAAAACTTTTACAGGCCGTCCTGGGCAAGGCTTGAATCCTGTTTGGATCTCCAAAGGCCTTAAAATACTCTGGCATGCCGGGAGACTGGCTCCAAAAGGGAGGAGACCTGTGCTGGCAGCCCTGGCCACACCTTGGTGGGACCGGCTCCTGGCCTTGGGGACCCTGCCACTCTCCTAGCTGTGCTTCCGCAGAGCTGGACACACAAAAGCTTTCTTGTCTGGATTTGTTCCCCTAAGAGGGTGGCACCCAACTCGTCCTGCCCATGCAGGAAGCTGGTCCTGTCCAACCAGGGAATGAAAAGTTGGCCAGTATCTTCTCAGGCCACGCTACAGCCAAGTCTCTTTTAATGAGCTGGTTCTCTTAGGATGCCCAGGGCAGGCAGAACACACTTGAGTGGGATGGCGAATGAAGAAGGAAGCGGCTGTTCAGACAGCTTCCAGTTCTGTCAGGTTCTGCTGCTGTGACCAAGGCACCAAGTCATCTGGAAACCCACTGCAGGCAGCAACCTCTTTTTCACCTTTGTGTGCCCCAAAGCTTGCTCCGGGAATCGATGGTTTGGGAAACAATGCTTGCTGTCTTTGAGTCCTCAGTCCTGTAAAATGGGGAAAGTATACATCAGAGGGCATTTGAGAGTAAGGCAAGAAGCGCTTGGCATGTGCCTGGCACATAGTACCTGTTCAGCAGATTCCCTTTCAGCTCAGGGTTAGATCTTCATCCACCTCTTGTTGGCCTGAAGGAAGGGGAGGTAGCTACTATTAGCCCCATTTATTTTATTTTATTTTTTTATTTTTCTTGAGACAGTCTTGCTCTATCACCCAGGCTGGAGTGCAGTAGTGCCATCTTGGCTCACTGCAACCTTCACCTCCCAGGTTCAAGTGATCTTCCCGCCTCAGCCTCTCAAGTAGCTGGGATTACAGGCATGCACCACCACGCTTGGCTAATTTTTGTATTTTTAGTAGACAGGGGGTTTTGCCATGTTGGCCAGTCTGGTCTTGAACTCCTGACCTCAAGTGATCTGCCCACTTCAGCGAGATTATAGCCGTGAGCCACCACATGTGCCTTATTAGCTCCATTTTATACCAGGTGAAATTAGACAGCAAGAGGCTAAATGCCATGGCTGAGGTAAGATCTGTGGTAGCATCCAAGTCTTGACCCCAGACTTGGTGTACTTCTCATCACAGATGCAATTTTGTGCCTCATCATCTGACCCACGAGCTACACATCTGCTTTTTTTTTTCTTCTTTCTGAGACAGTCTCACTCTGTCACCCACGCTGGAGTGCAGTGGCACAATCTTGGCTCACTGCAACCTCTGCCTCCCAGGTTCAAGTGATTCTCATGCCTCAGCCTCCCAAGTAGCTGCGACCACACGTGTGCGCCACTACCCCCAGCTAATTTTTGTCTTTTTAGTAGAGACGGGGTTTCACCGTGTTGGCCAGGCTGGTCTTGAACTCCTGACCTTGTGATCCACCCTCCTCGGCCTCCCAAAGTCCTTGGATTACAGGCGTGAGCCACTGCGCCTGGCTAAAGTTGTTATTTTAAAATTATTATTTATTTATATTTGTTATTATATTTTTTATTTATATATATTTTGTTATCTTATTTTTAAAAGTTGTATGGCCCATTTAAACTTTTGCAGAAATAGTTTTTTGAATCCATGGATTTAATGCTTTCCTCTTTAAATTTTTTTTAAGTCAATTTAGAGTTTTTAACACAAAAACTGGAAAACGGCTTTGCTCTTTTGTGGAACTGCTCTGGATTTTTTTTTTTTTTTAAGAAAGAATTTTGCTCCATCACCCAGCCTGGAGTCCACAACTACAATCATATCTCACTGCAGCTTTCAACTCCTGGGATCCAGTGATCCTCTTGCCTCAGCTTCCTGAATAGCTGGGAATACAGGTGTGCGCTACCCCACCAGGCTATTTTTTTTTTAATTTAAATTTTTTTTGTAGAGATAGGGTCTCTCTTTGTTGCTCAGGCTGGTCTTGAACTCCTGGCTTCAAGCAATCCTACCACCTCAGCCTCCCAGCGAGTTGAGATTAAAGGTGTGAGCCACTGTGCATGGCCTGTGTTGAATTTTTTGTCTCCCCATTCCCAAGTAGCAACTCTGGACTCCACAGAAAGGCCGAGTCTCTCCAAGACCCAGCCGTCTTGGAGGGTCATCTGTCCACTCCTCCAAAGAGGGTGAGACAGGGCCAATAATGAAGTGATCACTGTGCACCAACCCTCCCTCTTGCTTCACAAGACACCTTTTCATCCCTGAGCCAATTAATCAATTTCAAGAGATAGCATCTGAGTGAGATGGGTCACCAAGTCACAGAGGCCCTCAGCTCCTGTGCCGGCTCTCAAACGGGCTTCAATGAGGTGGCCTTAACACATTGCCTAGTACCCAACTTCCTAGAGTTCGTATAGTAGAGAGCAAGTAGCATAGGGCTAGAAGGCCAGGTCACAATACCCTCTCTGGAGTCTTCTGAATGTATGACCAATAGGCAAGAGCCCCAGTTTCCTGGTCTACAGAAGTGACAGATGGGACCCTACCTACCACACAGGTTCTCAGGATAAAAATAGTGATATGGGCTGGGCACGGTGGCTCGTGCCTGTAATCTCAGCACTTTGGGAGGCTCAGGCGGGTGGATCACTTGAGGTCAGGAGTTCGAGACCAACCTCGCCAACATGGCAAAACCCCATTTCTACTAAAAATACAAAAATTAGCTGAGTGTGATGGTGCATGCCTGTAATCCCAGCTACTCAGGAGGGAACTGCTTGAACCCGGGAGGTGCAGGTTGCGGTGAGCTGGCATCATGCCACTGCACTCCAGCTTGCGCAACAGAGCGAGACTCTGTCTCAAAAAACAAACAAACAACAAAACAGGTAATATGGTTGGAAGAGGTTTATCCTTGCCAAGTTTTTGTAAATCAAACAGCTCTTGAGAGATGCCTGTTTGCCTGTTTTTATTTTTTTAGAGATGGAGTCTTGCTCAGTTGCCCAGGCTGGAGTGCAGTGGCGCGGTCTCGGCTCACTGTAAGCTCCGCTTCCCGGGTTCACGCCATTCTCCTCCCTCAGCCTCTTGAGTAGCTGGGACTACAGGCGCCCGCCACCACGACCGGCTAATTTTTTTTTGTATTTTTAGTGGAGACGCGGTTTCACCATGTTAGCCAGGAGGGTCTCGATCTCCTGACCTTGTGATCCACCCTCTCCCGCCTCCCAAAGTGCTCGCATTACACGCCTGACCCACCACGCCTGGCCTGTTTGGCTGTTTTTTTAATAGGAGGTGGGAATCCCTTGTCTTCCTGGGCAGACTAGATGTGATGTGTTCACAGGGAGCTTTGTACAGATTGCTTGAGAGAAGCACCTTTCTTTCCAGAGTGGCTCCTTGGACGATGCCTTCCAAAGCTGCTAAGTCCTGTGGCAGGGGATTGTTGATATTCTTCATGGTTTCTCTGCGGAGCCTCCTACCCTCTGAATTATTGATGCATGTCTACATTATTATTATTTTTTTTTTGAGACGGAGTCTTGCTCTGTCACCCAGGCTGTAGTGCAGTCGCGCAATCTCGGCTCACTGCAAGCTCTGCCTCCCGGGTTCATGCCGTTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGCCCCCACCACCATGCCCGGCTAATTTTTTTTGTATTTTTAGTAGAGTTGGGGTTTCACCGTGTTAGCCAGGATGGTCTTGATCTCCTGGCATGTCTACATTATTAAAAGGGTCTCTTTGCATGAGTTAGCAGAATGTAGTGCCCTCTCGTGAATGAGAAAAGCCGCCCAGTCCTGATTGCAGCCTCATAATGGGTCTGAAATGACAAGTGTGAAGCAGTGGGCAGAGCCAAGACCACCTTTATTTGTGCATCCGTGCTCTTGGGTGGGTATGTTTCACACAGTTTGTTGTCCTTCTCTCCCTTGCCCATGAGGCCTTACAAACTCAGCTTGTCTCCACCCATTCCTCTACAACCCACACAACAACTTGTAACCTTTTAATCTTCTTTGCTTCCTAAAGATGCAACTCATGCCACCTCCCCCAGGAAGTTCTCCCTGACTTCCAATCTTTACAATAGGCTGCCAGACATCCCTGTGTTAACTGTCAACAGAGCCCTTTTCATCCTCTTGCATCACAATTCCTGTCTCATCCACTCGACTGAACTTCTTGGGTAGGAATGCAGCTCTGTTTTTTTTTTGTTTTCTTTTTGTTTTTTTGTTTGTTTTTAAGATGGACTCTCACTCTGTTGCCCAGGCTGGAGTGCAGTGGCACGATCTCGCCTCACTGCAACCTCCGCCTCCTGCGTTCATGCCATTCTCCTCCCTCACCCTCCCCACTAGCTGGAACTACAGGCGCCCACCACCACGCCTGGTTAATTTTCTGTATTTTTAGTACAGACGGCGTTTCACTGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCACCTGCCTCCCCCTCCCAAAGTGCTCGGATTACAGGCGTGAGCTACCACCCCCGCCCGCAGGTGTGTTTTACATGCATCTCACTCCCTCCGACACCCCCTGGAACCTACCACCTGTTTTATCTCTGGGGGCTGTTGGTTGTAGTACTGCGGAAAGGTTTCTTAAATGAGGTGTGTTTAGAATTTAGCCCTTTGCAGGGTATAAAATCTGAGAAATAAGGTGTGTGTTGTGACGAGGGATGGCACTGGGGGCCTGCCTAAACCACTGGCTTCATTGTGGGCGCTGAGGTGCCTTGTTTCCTTGGAGCTAATGGTCAGAGTGAGGAGCTGGCGACTGAGCTTGGATCTAGATTATTCTTGCATCAATCGCCTAAATCAACACTGTTTTCTCAACTCCCTATAGAAGAGGGAGATCCTCATGGCTTTCAAGGAGTCATGCCCAAGATACAGGAATGGCTCTCTGGTGGACTGGCTCGGACAGAGGGGAGAGGGTGAAAGTGGGGAGGACGAGGAAGTTTAACAGTATTTGAAGCATTTGAAAGCCTAGACCCATCGTACGCTGAAACAGAGAAGAATGGCTAGCCAAAAATACTCTGTCAGTCTAGCAACTTAAGAATGCTAGTCCTTGACCCCAAACATACTTATATAGCAGACTCAACATTATTGTCTTCCACCTACCGGATGGGATTATGCAAGTGATATGACCCAGAGCATTCTGGAAGCCGCCAGGGGCATAAATAATACATTAGATATGCAGATGAACTCCCCAGGGTGTCTCTGGTCTTGGGAACAATTCTTAGTAGACCTGACATAATTGCAGAACAGAGTGTCCTGTTTTCCCATCCACAGCCTCCAGGCCTGGCGAGGATTTTGTGTTCAAAAGAGATTTCCAAGGTGGACATCTCTCTGACACTGGCGATTTTTCTCTCTCACTTGAACAAAACTCGGTGGAAAGGTCACTCCTATTTGTCTTAGCTTCTCTGTCACATCCCACCCACACTTTCAAAGGTCTGTTCTTAGCGGGGTCCCAGGAACGCTGTGCTCGCCCTGTCACCCCTGAGCTGGGTGGTAGTCCTTTATCAGAGATACCCATGAGAATCACTCACCCTGGAGNNNNNNNNNNNNNNNNNNNNGTGACTGGAGCTTTAAGAGCTACTGAACTAACTGGTAATAAAAGTGAACAAAGTAACCAGTCTGGAAATGTCAGTAGAATGGAAAGAAAGAACAGCTGGGAGACTTCTCCATTTTTTCACGGTAAGACCCGGTTACTTGGCTTTTGTTGAGTCCCTGGTGGGTGTCCATGGTGTCTTTGGCCTTATCTCCCTACTAAACAGGATTACCTGTGTGGGGCACCTTTCCTGGTCTCCTCTCTCTCCAAGGAGCAGGTAGTACTTCGAGGCCGTGGTTAATCACATTTCCTAAGTGAGCTTTTCCTTTCTACAATAATCCTTGCTCTTACCCTTGCATTCCTACTGCATGTTCCCTCAGGCTGAAGCCTTCCTTTACATGTGAGCATTCTCCTGGATCAACTCCCTGATGACTGGAGCCTGTGCCGTGTGTTTCCAAGTTGCACCCACCACCCACGGAGACTAGCTCATGGCCGAGTGGCAGCTGGTGTAGCTGATAGCTGTCTGGGAAATGGGTCTGCACAATATAAAGACAGCTCACAGCAAAGCGCCCCCAAATGGTACTCTCTTTTTTTTTGAGATGTTGCCCAGGCTGGAGTGCAGTGGCGCAATCTCGGCTCACTGCAACCTCTGCCTTCCGGATTCAAGCGATTCTCCTGCCTCACCCTCCCAAGTAGCTGGGATTACAGGTGCCTGCCACCACACCCAGCAAATTTTTTTTTTTTTTGTATTTTTGGTAGAGATGGCGTTTCGCCATTTGGGACAGGCTGGTCTTGAACTCCTGTCCTCAGGTGATCCGCCCACCTCGGCCTCCCAAAGTGCTGGGATTACAAGCGTGAGCCATTGCACATGGCCTTTTTTTTTTTTTTTTTTTTTTTTGTTGTTGTTGTTGTTGAGAAGGAGTATTGCTTTGTTGCCCAGGCTGGAGTGCAGTGGTGAGATCTCAGCTCACTGCAACCTCCGCTTCCCAGGTTCAAGCAATTCTCCTGCCTCAGCCTCTGGAGTGGCTAGGATTATAGGCGCCCACCACCACACCTGGCTAATTTTTGTACTTTTAGTAGAGACAGGGTTTCACCATGTTGGCCAGGATAGTCGAACTCTTGGCCACCGCGCCTGGCCCCAAATGACACTTTGATAAGTTGCTCTACCCAATCCTAAAAAAGGAAATACAGATAAAAAATACCAACGTTGTATAATACACATGTTGTTGATGCGCTCTGTTGTTGCCAAAAGCTCTGTTGCTGGACGGAATGCAAGTGGATGTGGCCCTTTGGGAAGAATTATGGCCTTTTGGCATTCTCTATCCAAACTACAAAAGCATGTGCCCTTTGACCTGGCCATCTCATGTTGGGACATTGGGATATTTCCCCTACAGAGATAACCTATAGATATTTCTAGGAAAAGAACAGTGCCCAAGGTTATTCATGGAACATTTTTATAAAAGCAAAAGACTGGGAGTAACTCAAACATCTGTGAGTTGAAGACTGGCAAATGATGACACATTGTGCTAGGCAAGATGCGGAAAGGAATAAGGAAGTGCTGTGTGCACAAACACGGGGAGATCTCAGGATGTATTGTTGACACAAAAAGCACAATGTGGAGCGGGGAGTATGGCATGCCATCTTTTCTGTAAAAAAAAAGCATGGGTGTAGAGGGGATGTAAAAATGTGTCTTTGCACAAACTCTGTTAGGATGCACAGGAAACCAACACAAGTGGTGGCCTGTGCGTGGTGGGAGGAGGGAGATGCAGGGAGGCGAGACTGGGTTAGGGAGGAAGATGCATGAAGAAGATTTTTTTTTTCTTTTCAGAGATAAGGTTTCACTCTGTGGCCCAGGCTGGAGTGCAGTGGTGTGATCATAGCTTGCTCCAACCTCAGACTATGAAGGAGACTCTTGATTGCGTATCTTTGGGTATCATTTGAATTTTGAAGCATGAATATATTGAAATCGGCAGCAGCTCAAACATTGAGTATATTATCTATCATACATTTAATTTAAAAAGTTTATAACCTTGTCATGATTAGGCTGGGGTTATGCATTTTTAGGAGGGAGACCCCAGAGGTAAAACGTCAGTTCTTATCACATGTCAAGGTTATGTTCTATTCACGCGACTGATATAAATCCCGGTTGCATATCCCTATAATACACCTGACCAAAGCCAGGTGTGGTGCCATCTGCCTCTAGTCTCAGCTACTGGGGAGGCTGAGGCAGGGGGTTGCTTGAGCCCAGGAATTCGAGGCCAGCCTGGGCAACATAGCAAGACCTCATCTCTCCAAAACCACAAATTTGGCTGGGCGCAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGTGGGCGGATCACCTGAGGTCGGGAGTTCAAGACCAGCCTGACCAACATGGAGAAACCCCATCCCTACTAAAAATACAAAATTAGCCGGGCGTGGTGGCACATGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCGGGAGGCAGAGGTTGCAGTGAGCTGAGATCGCGCCATTGCACTCCAGCCTGGGCAACAAGACCGAAACTCCGTCTCAGATAAAAAACAAACAAACAAACAAAAAAGGCCAACAAATTTGACCAATACTCCTCAAAACTGGAAAAGCTGGTGACCACCACCCCTAGTGCTCCAATAAAGGGCTGTGGGAACAGTTGTGCTCAGGGTGGTACTGGTACAGCCTGGCAGAGGACATGATGCTTGCATAGTGTGGAAAGGCCCTCTGAGATATTGCTGGGCCTTAGGGGAGGAGGTCCAGGCCTAGAGAGGACTGAAGCCCTCCCCAGGGCATGGTGTGGACCACGCTCAACCGAGGTCGGGTTGGAGACACAGCTGGGAGTCAGATCCCAGGGGCTCTCCTGTGTGATGCTGAATTGCTGGGAAGGGGATGCCAGCTAGTCTCTTTCTCTGTGCCAACCCTGATTGGTTGGGTGGCTGCTGAGAGCCTTATGGTGCCCTGGCTCAGTAGGAAGAGTGTGTGTTCATTTAGTGAGTTTGCCAAAGACAAGGGAAGGGCGTTAGACAGTACCTCGCAGATAATGCCGGCCTGGGGATCCTGGAGGTTTTAGGCTGGCAGACCCTGGCTGAGGCTGTTTTCTGTTCTTTTCCTTAGCCCTTGGGAGACCTTTACCTTTTCAGTGCCTCTAAGACAGGGTCAGAGCAGTTTGGTGACAAAGTGGAAGTAAACCATGGGTGAAAAACAGCTCTCGGGACCCTCATACCCTTCCACTTATTGAGGATTAGGCAGAACTTGCAGCTTGCCCCACCTTTCGAAACAAGGTGTTCCCAGGAGGTGGAAAGACTGGTTTTCAATCAGATAAAGGTAGGATCCTATGAAAAACTCCTAGGGCCTTGCCGTTCCTATGAAGTGGTAGCTATCATTCACACTCCTAGTTATGCCATCGAGGTAAAAAGAGGTGGAATAAGAATCAGGGACACTTGAAAATAAGAAAAGAGAAACACTGCGTGCATGTGCATGGGTGCACAGCCTGTACATATCTGTCTCTGTCCCCCTGCGTGCACGTGCATGGGTGCACAGCCTGTACATATGTGTGTGTGTGCCCCTGCGTGCACGTGCGTGGGTGCACAGCCTGTACATATGTGTGTGTGTGCCCCTGCGTGCACGTGCGTGGGTGCACAGCCTGTACATATGTGTGTGTGTGCCCCTGCGTGCACGTGCGTGGGTGCACAGCCTGTACATATGTGTGTGTGTGCTCCTGCGTGCACGTGCGTGGGTGCACAGCCTGTACATATGTGTATTTGTGCTCCTGTGTGCACGTGCATCGCTGCACAGCCTGTACATATGTGTATGTGTGCTCCTCCTTGCATATGCATGGGTACACAGCCTGTAACTACATGTGTGTGAGCCTGTGGGTATGTGAGGGGAGTGAGGGACCCTGAGGGACTAGAAACTTCCTTAAAGGCCATTTGAGAGAGTGCTGCTTTCTATACCACCCACCCTAGGGCAGTTAGGCAAAGGTGTGCCTCCCTTTAAGAGGACCTAGCGGTCGGTCTGGTTTACAACATAGGTTATCAGGGAGTAGTACTTTCCCCTCGAAAACCAACCTTTATTTTGGAAAAGATTTCTAATCTCTGTGGCTTGTTTGATACACATTGGAAACCTGACTGGAAACTCAGGCCACCAGCATCTGTTGGGGGCACATGTTTGCACTTTTGGTTATGATGCCACGGCCCTGGTTCAGGTATCCTAAAGAAGATAATTAATGATCAAAATGATTGGTGTAGATTTCATACCACAGAGCACTGTGGTTTGTATAGTAAGACACAGTGATGGTGTCGACCCATGCACACCCAGCTTTCCACATCTTAACAATACCGACTTTGCCTGACATAATTGGTGTCTGCACATGGGATTAAACAAGTAAGATTGATGTGAATTTTATTCTTTCATTTTTTATGTAGACTCACTGATTGGGTAACTGTGGAAATAATGTCACAGTGCCTTTTTAAGTTAAGAACATGTAGTTGTGATCAGGAGCGGTGGCTCACGCCTGTAATCCCAGCACTTTCGGAGGCTCAAGTGCCTCGATCACCTCACCTCACCAGTTCAAGACCAGCCTGGCCAACATGGCAAAACCCCGCCTCTACTAAAAATACAAAAAGTAGGTGGGCGCCTGTAATTCCAGCTACTGGGGAGGCTGAGGCAGGAGAATCACTTCAACCCAGCAGCTGGAGATTGCAATCACCCAAGATCGTGCCATAGCACTCCACTTTGGGTCATAGACCGAGACTCTGTCTCAAAAAAAAAAATTAAAAAAAAATAAAAAAAGATAAAATCTAGTTATCAAAACATTTCTAAGCATTTTTAAGCATTTTATATTAAAACAGGAATTCAGAACAAATCAAAACGAAACAATAAAACTGGGGATGAAGGAAACTCAATTTTAAATATAAACTTTGGCAGGTGGGTGGTCAATCCGGGTGTTCTCAGTCATTTGCTGGCTTGTTTGTCACATGGCCTGCTCTATAAGTGTCACCCTAATTGATCTATTCGTTTGGAGTGGGTGCTCTTCTGAGGTTTTTGTTTCCCCCTTTCTTTGGGCTGCACTGTCTGTCCATGGTAAGAACAAGGGGCCATGCAATTAGAGAATCTTGAGTTTCTAATCCAAATTCAGTTCCAACCAGTGTCACCTGGTTCTTTAACTCCTTTGAGCCACCCCCGCCCATGGCCCTCATCTGTACCCTGAGGATAATAGTGTGGGCTTTGCAGGCTTTTCGTCACCAAGTGACATGATGTAGCAAAACACCCAGCCCAGAGCCTAGCACCAATTGGTCTCTAATCCATGCTGCACGGACACAGCCATTCTCTGGATCTCGCCTCTTCTGCCTCCACTGTGAGCTCAGAGACTCACTCACTCCACGACTAACCTCTCCTTGGCAAGCAGCGGGAGTCATTTCATCCCAGCCTTTCAGGAGGGTGAATCTCCACCTCGGGTCCAGAGTCTCAGAGATGAGACGTGAGCCAGGCGCTGATTCATCATGATGCAGGCTGTGCAGACTCTACCCATGGTTTCTCCATGCAGGAGTCAGGTTGGGATAAGGGGTCTTTCTCGGGCCTCTGTGCTCTCTCGCCCCTGCTGCTCCGGACTCGTTCATTGGACAAACCTCTCACATTCTCTAGACCGGTTGCCACGCCATGCTCACAGTCTCTGTTCTTGCCTTCCTAGGTGGGAAGTGAGTGATGACCCTGAAGTGAGGACTCATCTCTAGATCTCCAAGGGCTGCACCTCAGCCACCACTTTACAAGCGTGATCTCCAGCCAAACTCCCCTCTTGGCTGACCATAGGTGACTCTGGGTAGCCCATACCCAGGCTCAGCAGCAGTTGGGGAGCTGCCTCGATTTCTGGTTACAGAATTCCTGGAACTGAGTCACTGCAGTAATTCCTGTGATGAATTGTGTTTACTTTGTGTGGGATTCCAAACTGTAGCACCAGTGACTACAGCTGGAAGACAGCATCATCAGCAGCTTCCAAGCCAGAGCCTGCCGTCAGAAAGCTCCATTGCCCTAATGCTCAAGCCTGTGCGAGCCTGTTGGAGAGACACTTGGATGTTTAGCGAGCTGGTGACTCTCCTTGTCATGAGTAAGCTTAGGACCTTGGGCAAGTCATCCAAACTCTTCTGCGCAAGTCATTCTCCTGCTTGGATGCCTTGAGGCAGAGAGGCAGTCAGGTGAAGTGGTCAGTGCGTCGACTCTGCCTCTACCCTCCTCGCCTTTGAATCCACCTGTGTGATGTTGTATGATATTGACCTTTCTGGCTCTCAGCATCCTCTTGTGTGAAATAGGAGATTTTAACAGTATCTATTTCGTAGGGTTGGTGTTTGAATGAGTTAACATATGTAAAGTGAATGGTACAGTGCCTGGCTTCCTGGCAAGATTGCTATCAGGATTAAGGCAGCTTAAGCCCTTGGCACACACTAAGACCTCAATAAATGTCAGCTGATGTTATTGGTCCTTTATTACTATTCAAGAAGCCTGCCCAGCCCTCCTCCCTCTCCATCCACACAGCAGCCTGGTACCCGCTGTTCTCTAGGTTCTGGACACACGTTATGACATGTTCTGATGATCTGGCTTAGACAGTGGGGCCCTCGAGGTAGGCCCAGAGGACTTGGTCCTCACTGCCTCTGTGGCGCCTTGCACTGGGTCCAGCTGACGTGGAGAGAGACTCAGGAAACAGTGGCTGAGTGTGACTTTGGCTGGCATAGTGGTTGCTGAGAGAACAGACAAGGTTCTCTCTCACGACATACAGATTTCAGATCAGGGAAAGTCCCAGCTGGCATAAGTTTATCGAGCATCTCCCATGGACAAGATCAGCTGTGGGTGGAGCCTTGAAGTACATGGTAGAAGGACACCGAGTCTTCCCACGCCACCGCTTCAAGTGAGGAGACAAGATATAGCCTCCCAGAGAATTCCTATAATGCAATCGTGAAAGAACCATACCCAGCAGGAGGCCGGGGAAAGTGACTCCTGCAACTCTAGGAAGGCTTCCTGGAAGAGGTGGAACGTGAGCAGCATAGGATTTTGACAGAAGAAATGGAATGGGCTGAGGGAGATTCTGCTGCTGCAGCTTCAGGTTGACCTAAGGGCTGGCAGCAGTGGAGGCCCCCCACGAGTGAGTTTGAGGGGCCTCTTTAGCTCAGTCCAGTTGAGGCAGCAGAGCCTTTCCATAGGGGTGTGGTGTGACCTGAATGTTGGGCACGTGGTCGTAACTGAGCTTTAAAAGTGAATGAGAGGAGCCATGCCTGATGGCTCGAGCCTGTAATCCCAGCACTTTCGGACATCAAAGCTGGGGGATCACCTGAGGTCAGGACTTCGAGACCAACCTGGGCAACATGGTGAAACCCTGTCTGTACTAAAAATACAAAAATCAGTTGGGTGTGGTGGTGGGTGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTCCAACCTGGGAGGCAGAGACTGTAATGAGCCAAGATTGTGCTGCTCTACTCTAGCCTGTCTCAAAACAAAAAACAAGAAACAAAAACAAAACAAAACAAAAAAACACTGTCTCAAAAAAAAAAAGTGAATAAAGAGAGAAGAAAGGCGGGGCACGATGCTTTTTAAGTCTACGAGCATCTTATAGCATTGTTTACATCCCAGCTTTTCACTGACCCTTCCTTTACCCCCGCCCCCATCCCGTGGCCCTTGCTCTGTCCTGCCCTTTCTGTACGGCGTTTTCTCTTCCCGGCTCCTCTGCCCCCAGCCCCACGTGCCAACTTGTTTCAGCCTGGCAACGAGGCCTGCTGGTATCCCAGCCATTTCCTGCCCCAAGGCCGCCCACCCTCCTCCGATCTAGCATGGCCTTGCCCTCCGTAGGCAGGCCTCACCCCTGCGGCAGCCGGGAAGCAGGGCTCCTGTTTTGCCTGTTTACCCTGGCGCAGGGACAGGTAGATCATGTAGCACTGCTGGGATGCCAGCTGCCTAAGTCTCCGGCAGTGGGCACAGGCGGACGCCACGCCCCATTCCTCTGGGCTGACTCGAGCCCGGCCTGCCTGGCACAAGACCCCCTGCTCCTGGAGGCAGCTCAGGGGCTTGCTCATGGCTGCCCTGGCTCTCCGCTGGGCCGCTGAGTCATCGCTCAGCAGTGAGGCCTCTGAGTCACAGTGCAGCCCTGGACTGGACAGTGAGTGCCTTGTGGGACCCTCCTGGGCTTTCCTCTCCCTCAGAGCATTTAAAGGGGTCCCAAATTGTCATGTGACCCTCTCTGATGCCAGACAGACACTCTAGGTCTTTCGCGCCCTGGTCATTTTACAGAACTGTGGCTGGATGCCAGGCATTCAGAGATACATTCCTCAATCTCGGTCCGCCTTACAGGATCCAGCATCGAAGAGTTCAGTTCAAGTCAGCAGCCGAGTTACAGGAAAGCAGCCAGGGCAATGATTCAGCAAGTCCAGGCAGCAGTGAACCAGGCAAGATTTCGGGAGCAGAGGCCTGGGTCGCGTGTCCTGGCAGCGCCACAGGAAGAGCATACACATCTCCTGCGTCTTCGTATTTTGTGAGTGTCTTGAAATGACCTTGAGAATCTACGCAATACCATGAAGAAGCACGAGCAGGAATACCATTTATCCATTGGCACAGGGTAGCATGCTCAGTGTGCACTGAGGTTGTGAATTCTTGTCCTGACCCAAAGATGCTGATGCTGTCCTTATACCCATTTCACGCTTCAACAAACTGAAGCTGTAGTAGGAGAAGATACTGACTCAGAGCCACAGAGTTAGAAAGCAGCATGTCTGGGATTTGACCCCAGACCTGTCTGACTCAGTTTACTATTTTAAACTACCCGATTCAAGTTAAGTTTCTCTCCTCTCTCTCTGTCTCTCTTTCTCCCACGTGGCTGCTGGAATCTTCCCTAAGGACCATACCTGTCTGCAGTGCAGGAAGCCAACTATTAAGGGGAAACAAAACTGTTCTTAGGAGTCCTGCTGTCACTGTGGATTGAGCCGGTGAAGCCCTGAGGGATTTCATCGCTGAGGTGGATGGAGAAGCAGCTGGGGGCCTTGGCTGTAAGGACCCCTAAGGGTTAGTGTCTGGAGCTTGGGGGATGGGAATCGGTCCCGGTGTGCGGAAATTGGATGGCTCGCTGACCCCAAGGGGAAACCCTTGTTGACGCTGTAAAGTGTCTTCTGGCCTTAGAGAAACCCTCTAGGGTTCAGGTTCCAGCTTCACCCTCCTTTAGTCAGGTGGCTTTGGGGGGGACATTTCTGCTGGCCCTGGCAGACACTGGACTAGAGCAGTGTTTCTAAAGTGTAGCCCCTTCTCTCTCCCGGGAAGGGAGACAAGTGCGTGAGGGGATTGGAATCTGCATTCATAACACACTCCCCAGGAGAGACTGGAGAGCACCTTTCCCCCTGAACTCCCGTCATCTCAGGCCTCAGCAGACTGAGCGGGAACCCCCACCAGCGAGGTTGCTCAGGACAGCGTTTCTCTTGGGCCTGTGTTTGGAACAAGTATCCTTTGAACTAATCACTAACCTGTGAAAATGGATACACCTCGTGTGAAAATGAAAATGTCTGGCTTCCCTTCTGAGGAGCGGAGGCATGAAAGGTGTGGCCGGTAGCGGTGGGGCCCCCACACCTGTGCAGCCGCCCTGGCCAGAGCCCACAAGCAGCGTCCCCTGGTCATGCCCCACTCCCTTCTCCATAATCTCGCCCCTCCCTGACCAGGCCACCTGACCTTGCCATTTATATTCAAGTTCATTCCGTTGTTATTCTTTTAGAAAAGAGAGATGAGAAATATTTCTTGTGCCTACATCTTTATCAAAAGTAGAGCAAGAAACTTGAGGACTCTGTTTCTAGAAAAATGAGAGTCGGCATCCCTCTTCTCTGAAAGGAAGAATTTCCATACCTGCCCTCTACCCAATGTCTAGACGAAAGGATGAGTGTCCTTTTGGTGTGTGGAGAGCTTTGATGGGGCATGTGATGTGTAGGGCTTAGGGGGTATCCTGCCGTGGCTGGGAAAGGTGGTTGGGTGTCCTGGGAAGGCTTTTATACACACTCCGTGGCAGGCCTAGGACTCTAAGTGCTTCCAGCCAGCTGTACATACGTATATATTTTTTTTTCTTTTTTTTTTTTGAGACGGAGTCTTCCTCTCGAGTCCAATGCCATGAACTTGGCTCACTGTAACCTCCCCCTCCCACGTTCAAGTGATTCTCCTGTCTCAGCCTCCCAAGTAGCTGGGATTACAGGCACCTGCCACCACGCCCACCTAATTTTGTATTTTTGATAGAGACGGGGTTTCTCCATGTTGGTCAGGCTGGTCTCGAACTCCCGACCTCAGGTGATCCTCCTGCCTCGGCCTTCCAAAGTGCTGGGATTACAGGCGTGAGCTACCACGCCCAGCCCCAGCCATCTATATTAACTCAATGCAATTCTTGTTGAGGACTAAAATGGAGTTTTTGTTCAACACTAAATAAGTAAATGACAGTGGAGTATTGTCATTATCCCCATTCAATAGATAAGGAAATTAAGGTTTAGACACTCACAGTAACTGGTCCTGGCTACACAGCCAGTCAGGAGCAAGGCTAACATTTAGGCCTAGAGTGCTCTCCTAACCGCTATGCCTGGGGTGACCACCCAAACCTTCCATCCTTGTGTCATCCCATTTGATATATTAGTTACTCAACCTGAAGCTAAAATAATCCGAGGCCTGGGCGAGGTGGCTCATGCCTGTAATTCCAGCACTTTGGGAGGCCGAGGCAGGTGCATTGCTTGAGGTCAGAAGTTCGAGACCAGCCTGGCCAACATGGCGAAACCCTGTCTCTGCTAAAAATCCAAAAATTAGCTGAGCGTCGTGGCAGGCACCTGTAATCCCAGCTACTCGAGATGCTGAGCCAGGAGAATTGCTTGAACATGGGAGGAAGAAGTTGCAGTGAGCCAACATTGTGCCACTGTACTCCACCCTGGGATACGGACCACGACTCTGCCTAAAAAATAATAATAATAGTAATATAATAATAATCCGAGAGTGCTTACCATCTGCCTACATTGTTCTGCGATACTGAGATGAATAAGACCTCTTTTGGGCTCTTGATCACTTGGTTATAAGAAGACGCAGCTCGGTTCCCCCAGGGACTCTCAACAGTTAGCGACAGGCTGGGGCATCGTGGCTCCTGCCTGTAATCCCAGCACTTTTAGAGGCTGAGGCAGGAGGATGGAGTATGTCCAGGAGTTTGAGACTAGCCTGCACACCATAGTGAGGTCCCATCTCTACAAAAAATAAAAAATTAGCTGGGCATGGTGGTGTGTGCCTATACTCCCAGCTACTCAGTAGGTCAAAGACGAGGAGATGGGAGAATTGGTTCACCTCTCCACTTGGAACCTCCAGTCTGCAGTCATCACACCACTGCACTCAGTCTACGCCACAGAGTGAGACTGCCTCAAAAAACAAAACAAAACAAAGCAAAAACAATTACGTACACAAAGGCAGGAGCATCCACATTTTCTGACATTGTTTATTGCTTTTTTACCCTCATGTTCTCCCCTCTCCTCGCATTGCCTGGCACTTGGGAGAACTTTCATAAATATTGGTCGAATGAATCAATGGATATTAAATCATTTGTGTTTTCTTTTGTGAGTTGAAACCGTCTTCAAATGAGTCTTCAAAGTGCTCTGATTCGTATGGTGGAGTGTGATGAAGTTAAACTCTGGGTTGAGAAGAGACGAAATGTGAGTTAAGGAAATAAAGAGAATGGAGTTGAATGTTCAGAATCTTTGGAGTGCTCTCAGGGATCCATCATTCTCAATTCAGTTATCATCTTTGCTGTGAGAAATCCCCAAAGATTCAAACTTCTCACCACAAAGGTGGTCTTACCCTGGGTGTGGTGGCTCATGCCTATAATCACGGCACTTTGGGAGGCCAAGGCGGCTGGATCATTTGAGGTCAGGAGTTTAAGACCAGCCGGTCCAACATGGTGAAATACAACATGGTGTATTTTGTGTCTCTATTGGAAATACAAAAATTAGCCGGGCATGGTGGCGGGTGCCTGTAATCCCACCTACCACGGACCCTCAGCCAGGAGAATCACTTCAACCTGGGACGCGCAGCTTGCACTGAGCGCATATTGTGCCATTGCACTCCAGCCTCGGTGACAGAGTGAGACTCTGTCTCAAAATAAATAAATAAATAAATAAATAAATAAATAAATAAATAAATAAAAGATCGTCTTCAGGTTTCCGTTTGGGCATAGGTTACCTTCTGCAGAATGCATGTCAGTGATATGGAGACAAGTTTTAACATGGGCACTTTTTCAAAACAGACATCTTAAATATTCGCCAAAACCCCAGATCTCAAAGTGGACTTTCTATTTTTGATGGAAAATTTCAAGCCTGTTTTCTGTAAAGCAATGATTATTGTACAAGGATTTCTGGAACTGCAACTGGCCCATAGATGGTGGCCATTATAGTAGTTTCCTATGAAATCTACTAATGTACAGCAAGCACTTCTGTGACTTTCACTCACCACTTGGTTTCTTTTTTTTTCTTTTTCTCTTGTGGACTACACTTGAACAATCCTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTGAGACAGGGTCTTGCTTAGGCCGGAGAGCAGTGGTGCTATCATAGCTCATTGTAACCTTGAGCTTCTGGGTTCAAATGATTCTCCTGCCTCAGCCTCCTGAATACCTGGGACTTTCGGTGTGTGCCACCACGCTTGACTAATTTGTTTACTTTTTGTAGAGACAGGGTCTTGCTATGTTGCCCAGGCTGGTCTTCAACTCCAGAGCTCGAGTGATTCTCCCGTCTTAGCTTCCCAAAGTGCTGGGATTACCAGCATAAGCCACCACACCTGGCCTGAAGGCTCGTTTGTAATCGCACTCTTAAGTGAGATAAATTGACTATTTTCTTCCTCACAACCTTCTTATGCTTGTCTGTAGTTGGCTGTCTCATTTTGGACAATTTTGATTGTCGGCTTGGCTCTTCAACTGCCTGTGTTGTTGTATTCTTACAACACACAGAACAACCAGGTCTGGGCTTCTTATCTTGCGAGGCAGGTGAAGAAAGACTAGGAACAATGTATTTGGGTGCCCACCTCATACCGCCCATGACCTTCTATTGAGGAACAGCAGGTAGATGAAGCAGCTTTCTCATATTACGCCGTGGCTGACTCCAAACTTGAACTCTGGTCTCTGTTTTTGGAGCTTGCTTCCTTCCTACGACCCTAGACTGCTCCTCCTAAATAATTAAGTGGCAAACATGGCACAGACAGTAACCTCACATAAGAAGCTATGAGGTTAGGACAGAAATATCCACTGCTGGCCTGCGAACTATTCACACAGGTCTGACTCCCCGCCAGACTCCTGGCTGCCCTGGTCCTGTGGAATCCCGTCATGGCTTCTGTCTAAACGGAGCAGGCTCAGGGCCATGCTGAACTTGGAGAAATCTGTGCAGGAGTCAGATTTGGGCTTTAGAGTCACCTGGGGTTGAATCTCGGGCCTGCTATTTATTGAACCTGTCCTAGCCTCAATCGCCTTATCTGTACCATGGCCATCATACCATCTACGTCGAACGTAGTTGCAGCAGATTCTCATGCACGCAGGCCCTTCCCCGTCATTTCTTTCTTTGTCTCTACAAGCAGAGAGGCTGAGTCATACAGATCCTGAGGGGAGATCACTTTCTCTTCCCTCCTTTCGTGTGTCATCTCCACCTGGGTGTGGTGAGCCCCAGGAATAATGCTGTGACATCAAGCCCCGTGAACACCTCCTTTCACACGGACCCCGTGACTGGCTGCGGCTGCCAGCGGTGATGAGAACTGATGACACTCCAGGGCTACCAGGAACGGTGTGTGTGCCTCTGGGCAGGGCCACTTCCTAGAACCATGGCGCTGCTCTCTGAAGACAACCGGCTCCCAGTGAGCTCCAGGAGACGAGGAGCAGGTCCTGGTGGCGGAGGTGCTGGCGCAGGAGGCCGGCTCCTGGCAGAATCGGCTTCCAGCTCTGGGCACTGGGGTGCGGTGTCGGACCAGCAACAGGCTGCTCCTCTGCCAGGAACCGCCAGAACCAAAGTCTTCTCGAAGCCATCTTCAGAAGGCAAGCACAGGGCTGAGCACTCCGGAGAGGAGCCTTTGGGGGAAAACTTTTTCTCGGAGCTTCGGAGCTCAGGGAGTACTATGGGGGAGATTCACTAGGTTGATGCTTTGCTGATAGGCAGCCCTGTAGAGAAGACAAGGCAGCTGGGCATGGTGGCTCAGGCCTGTAATCCCACCACTTCGGGAGGCCAAGGTGGCCGGATCACAAGGTCAGGAGTTCAAGACTAGCCTGGTCAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAAAATTAGCTGGGCGTGGTGGCACGCGCCTGTAATCCCAGCTACTCGGAAGGCTGAGGCAGAAGAATTGCTTGAACCCAGGAGGTGGAGGTTGTACTAAGTCGAGATCACGCCACTGCACTCCAGCCTGGGTGACAGAGCAAGACCCAATCTCAAAAAAAAAAAAAAAAAAAAGGCAGAAGACAAGGCGACAACTGAGCTTTCTGTCTCCTGTGCAGTTTACCACTTGGTCAGGTGGCCATTTCTCTCCCTCCTACTCGGTGACCTTCTCAAGGGCAAGGGGCTCCTTGAAGAGTGTCTTTCACATTGAAACATGCACAGAATGGTGGCTTATGACCCATGGTAGACGCGTGAACTTGGGATGCCACTGTGGACGTGTCCCCAGCCTCCCTCCTCATTGGTGTACTGATATCGTGTTGCCTTGGACCTATTACCTCACCTCTTCCTGGTGATTTCACCTCAATATCCCCTTTCTCCTATGCTTCTGTTTTTCCTTCTACCCTTCCATGTTTTTTTCTCCCAACCATTCTTCTGTATTTTATTCCACCCAGCCACCCTTTCATCTAACCAGCCTTCCACCTAGCTAGGCTTCCAACTAACTATCCTTTTTTATTGAGACACAGTTTCAACTGGCACAGTTGGGCCACTTGTTTCTCATCGGAGCCACTTCTCAAACAGGTCGATCACTAGGACTTTGGACAAAAGCATGCGTGCAGGCTGGGCGCCGTGCCTCACACCTGTAATCCCAGCACTTTGCGAGGCCAAGGCGGGTGGATCACCTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACATGGCAAAACCCTGCCTCTACTAAAAATTGATCAAATATAGATCACCCGTAATTATCACCCATCATTCTGACACTTAGCAATAGTCACCCTTAACATCTTGTTGTCTTGCTTTCAGATGGTTTTGTTTTTGACATGTTTTTTTTTTAACTTATATTATGACCATCTCCTCTATGTCTTTTAAAGTTTTAAAAACTTGTTTTGAATATCTTTTCCATATTTCATTATGCACCTGTACAGGAAAGGTACTCCATAACTACGTTTTTCTTCTCTGTAAAATCGGGAAAATAAGAACCCCTTCTACATGGGGTTCTTCCGAGGATGAGGTGAAGAAAGTTGTCAAAGCCCCTCGCTAGTACCAGGCACAGAGCAGGTACTGGGCGCATGTTGCCTGCTACTGGTATTATTGTCATTGTCATTGCTAATCATCAGCCAAGTCAGTCCTGCGGGGCTTTCAGATTTCCTCTGCTTTTACCTGTTGCAAGGTATAAACCTTTTCATGTGTCTCTGATTGTTTTCTTGGCAGAGCCACCCACACCCCAGGAATTTAATAGGGTCTTGATGCATTCCCAGCTTGCTGTTGACGAGTATTTAACCAGTCACCACTCCACAGGCAATATTAGGGGTTGCTGAGGCAGCCTCCAATAGTGTGAGCATTCTAATTACTGCAGCAAACTCTTTTAAAAAAATTTTAACTTTTCTGGCTGGGCGCGTTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGTCGAGGTGGGTGGATCACTTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCCGGGCATAGTGGCACATGCCTGCAATCCCAGCTACTTGGGAGTCTGAGGGAGTAGAATCGCTTGAGCCCGGGAGGCCTAGGTTGCAGTGAGCCAAGATCACGCCACTGCACCCCAGCCTGGGTGACAGAGTGAGACTCCATCTCAAAAGCAAAACAAAACAAACAAACAAAAAACAAACCACCCTGCAGTACTACTCAGCAACAAGAAGGAATGAACTACTGATAACACTCAGTGACTCGGAGGAATCTCTAAAGGATCATGCTGAGGGAAAAACCCAGTCCCACAAGTTTACCTGCTCTATGATTCCAGTTACGTATAACATCGTTGAAATGAGAAAATTTCAGAATTGGAGGGCAGATTAGTGGGAGAAACAGGCAGAGTCTACAAGGGATCCCTCCGTTATTTCTTACAACTGCATGTCAATCTATAATGATCTCAAGAAATAAAAATTCAATTTGAGAAACCTGCAGTTCCAAGTCTGCATTGCAGCTGGAGGTAGTCANNNNNNNNNNNNNNNNNNNNGGCGCGTTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGTCGAGGTGGGTGGATCACTTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCCATCTTTATTAAATATACAAAGATTAGCCAGGCGTCGTGCCAGCTGCCTATAATCCCAGCTATTCACCAGCCTCAGACAGGAGAATTGCTTGAACCCAGGAGGCAGAGGTTGCAGTAAGCTGAGATCATACCACTGCACTCCAGCCTGAAACACAGAGTGAGACTCCATCTCAAAAAAAAAAAATTAACTTTTAATTTTTATTTTTTAGAGACACGGTCTCGCTTTTTCACCCAGGCTGGATTGCAATCATACGTTCATAGCTCAGTTCATAGTTCATAGCTTAGACCTCCCAAGCTCAAGAGATTCTTCCACCTCACCCTCCCACAGCTGCACACCACTATGCCCAGCTAATTTTAAAATATTTTTTCTACACATCAGGTCTCACTATGTTACCAGGCTGGTCTCAAACTCCTGGCCTCGGGCAATCCTGGACTCCCCAGATGCTGGAATTATGGGTTGAGCCATACCCTGCACCAAACTCTTAAAACATGAGGCGAACTATCTTGTTATAAAGTTGCTTTTCTTTGACTACTGGTGTGGTTGGCCAGCTTTTCATGTTTATGGCTTATTTGTGTTTGTTAACTGGTCATTTCCTTTGGGGTGTTAGCAATTTTTTTCTCATTGATTTGTAAGATCTGTCTTGATTAACTTGTGAATTTTGCACATGGTGGAACCGGGGTGCCCCACAGTAACTCCCCTTGGTTAGCCATCCTGTCCCTGCATTCCACACCTCCATTTCTATGGGGGACATTTCTTTACAAATCTGCATCTGATTGTGATACCAAACCATGCTTTGCAAGTCAATACAAGGATCTACCCCATTAATCTGCCCAGTTCCTAGTTTTATTTATTTATTTATTTATTTATTTATTTATTTATTTATTTATTTATTTTTCCCACACCCTCTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGCATGATCTCCGCTCACTCCAACCTCCCCCTCTTGGGTTCAACCAATTATCCTGCTTCAGCCTCCCGAGTTGCTGGGATTACAGGTGTCCGCCACTGCGCCAGCTAATTTTTTGCATTTTTAGTAGAGATGGGGTTTCACTATGTTGGCCAGGCTGGTCTCGAACTCCTCATCTCATGATCTTTCTGCCTCAGCCTCCCAAAATGCTGGGATGACAGGCATGAGCCACCGTGCCTGGCCAGTTGCCAGTTTTTAATGTTCTCAGGTGAGTGGCATTTGCCAAGGAACTTCTCTCTTCCCTTCTGTCTTCATAAACAAAAAATCCTACTAACTTCAGGTGTCAGTTTAAAAGTCATCTCTTCTGGGAGCCCCACCTTAAACCCCTAAATCAGCTGTTGGCGTCGCGGCTGGACTTCTCCTTTGTTGCACCAATTGCAATTTCTTACTTAGGTGTGTGCTTGTGGGAACATTTTTCTAATATCACCTTCTCTGCTAAGGACAGCGATCATGTCTCTTTTATCATTTGGTATGTGTTGCTGCACCACTTACCACAGTCCTTAGCTTGGAACCCAAACCCCACAGCGGTACAATCACTTGCTTGAGGCCCCTCAGCTTGCACCTGGCACATCTGGGACCCGGTGTCTGGGCCCACCTTCAACCTGCATCCCTCAGGACCCTGTGTACCTCTGGCCAGGGCTTTGCTTTGCTCCCTGGATGAGAGTGGTAAGAGTTGCTGAGGTGCCAGGCCTTTGCCCCCATCCCCGCTGGCATCACTGATTCCAGGTTATTTTGGCTCAGCGCGGATGGAGCGAGATGTAGGGGAAAGGTTGGGACCGGCTTCCAGGTGATTGGCACATCCCTGCCCTAAACCCTCCATGGCTTTCCTGGGCCTGCCATCCAAGGGGAAAGAACCCTCTTTCCTCACAAGCTGAAGCTTGAAACCAATCAAGCTCCAGGCCAGAGAAGCTGCAGGTGGGGTGTGCTTTGCAGTCGGCGTGGGGCAGGAAAGAAAGGTTACGTGGGCTGAACGGGTCAGGTCAATTCAGTGTGGGTTGGAATGCTGGGGTCCTGGGTGGGCAGGGATGAAGGACACCTGGGGAGGGGAGAGAGCCTGCCGCCTGGAACTGGGGCCCTGCCAGTCCCCCGCTGCATGAGTCTGGGCATGCTTCCAATCTCTGGGAGCCTCAGCCTCCTGTCTCTAAAATGGAGCTAATGAGGCCTGCCGTCACGCTTTGTGGGCAAGATTCAGTAACTGGATGCCTCCTCCTGGCCCTTGGCAACCATTCAATAAATGTTCATTTCTCTCCCACCCCTCGCTCCTTCTCTTATTCTTTTCCTGTTGCTTTTCACACGGACATGTGTTGAATGTGGCAGGATATTTCTTTCTTTTTTTTTTGAGACAGAGTCTTGCTCTGTCACCCACGCTGGAGTGCAGTGGCGCGATCTCGGCTCACTCCCAGCTCCGCCTCCCCCCTTCACCCCATTCTCCTGCCTCAGCCCCCTGAGTAGCTGGGACTACAGGCGCCCACCACCACGCCCGGCTATTTTTTTTGTATTTTTAGTACATATGGGGTTTCACCATGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCGCCCGCCTCAGCCTCCCAAAGTGCTGGGATTCCAGGCATGAGTCACTGCGCCCAGCCACGATATTTCTAACACAGAGAAATTCTCAGTGGAGGCCGCGGGAACTAGAGATAGAGGTCCTCTTGCCTACCAAAGCACCAGATGGAGCTGACAGAGGCCATCTTGTCCTAGAGGGACCTGGCTAAGAGGATCTAAGACCAGAACTACTCTGAGTGCTTGGGATTCATATGGGGCTGTACACGCCAGGCCTGCTTGAACACCAGTGTTCCAATCCCACATCTCATTCTTAGAGCTCTGTGGCCCTGGGCGAGTCTCTTCCCACTATTTCTTCATCCTGAAGTGGGCACCACATTACTGCACCTCAATTTGGACGAGGATTCTCAGGATGGGGAGGTGGTTGAAATCATCCAGGGGTCACTGGAATCAGGATGGTCCTGGCTTTTTCAGAAGCACAAGGTCGTAGGTGCCAATCTGGGGGCTTTGCAGATATTGAACCGCAGCCTGAGGATCGGGATAAACCTGGGTGTGGCAGACAGAATTATGCTTCCCCCAAAGAGGTTCACATCCTGATCTCTGGAACATGGGGATGTCATATGCCATACAGAGAAGGGAAATTAAAGTCACAGGTGGAATTAAAGCTGACCTTAAAAGAGGGAGATCCTTTTAGATTATCCAGAGCGCCCAGTCTCATCACAGAGTCCTTACAACTGCGCCACAGACGCAGAAGAAGGGTTCAGAAACATGTGAGGTGACAAGTAACATTCCTGCCTTTGAGGATGGAGGAAGGAGCCATGAGACAAGGAATAACCGTCCCTAGAAGTTGGAAAAGGCAAGGAAATAGGAACTCCCCCAGAGCCTCCAGGAAGGAACACAGTCCTGCTAACACTCAGTGAGACCCACTTTGAACTTTGTATCTTCACAACTCTATCATAATAAATGTGGGTGGATTTAAGCCTCTGAGTTTGTACTAGTTTCTTCCGGCAGCCCTAGGAAGTGAATGCAATGGGCGCAGCATTTGATGGCCAGCCTGGCATCCAGCCTGTGGGGAGTGGGAGCTGAGGGCAGTCCAAGGGAAATGTCCTTTGAGTGTGGCACCGGCAGGCAAACCCTTGTTTGGGTGTGATCATCAGTGAGTTGGGCCACTGAAGCTGCCTGGTGACCTGGCAGGGATGGCTTAAGTACCCACCGTTTCCAGATCAGCGAGATAAAGGCGCTTGCATAAATTCACATGCCCATGGCTTCTCCCTCTGACAGCGCAGCCCTGCCTCCGGCTGCCTGGCCAGGATGGCGTGTTGGTGCATTAGGGACCCCTTCCTCTCCTGCCCTGCTGTTTAAATTGTTGGTCTGTTGGCGTTCTCAGGAGCCCTTTACCAGTACCCTTAGGCCCCAGACGACCTACTCCTCAAGCTGATCATATCTGCTGCCTGTCTCCCTGCTCTGGGCCCAGCACCCTCATGGTTTTCCATAACACGTATCCCAACTCCTCCTGATGGGACCCTCGTGAGCTGTCTGTGTAGGGAGCATGGCTGCCCCTGGGTCTGCTTTCCTGCCCCTGACCCACAGGAATAGGATGTGGCAGAGTGGGGGCCAGATGACAGAGATGCTGGTGCTCTCTCAGCTGAGGCCCACTGCTGACCTGCTGGTGGCTTGTCCTGCTCTTGGATCATAGGCACTGGGACATCCTGCCTTCCTTCACTGTCCCCTCCCACTCCCTCTCCTTCAGCATCAGAGGAATGAAGGAGGCCTGGAGGAGTAGCCCCTATCTAATAGAGACAGGAGTGGGCTGGGTGAGCATGGGGTGGTCGCAGGGGGAAGGGGATAGGAGATGGAGAGAGGAACCTGCTATCTGGTGGGTTCCAGGATGGTGACAGACAGTGGCAGAAGCAGTGCAGAGACCTTAGTTTGTGCTGCACGTTCAGTTAATCACTCGTCAACGCAGACATCACTGCAGGAGACCAGACTGTTATGTATTGTCTGTGCATTCATATTAGTACACAGGGAAGATCTTGGGCTCCGAGACCTAGGCAGATCTTGCCTCCCATCTGCCGACCCTCCGCAGATGCTACACATTATGCCAGGTAAACACATTATCAAGGAGCCTTGGGCCGTGTTAGAGGAAGGCTCCTTGTGCCTGTGACCAGTTTGCACTAATCCTATGTGTGTTTGTGTGTAAGGCTTGCATTCACTGATTCACTGTAGAGGATGACTTGAAACCCAAGTCATCAGCTGGGCAGTGCATGGGCTGCTCGCCTGAATGGTGAAGCTCTACCAAGTGGTTTCCACCTAGGGCCTGGCTTAGCTGGCCTCAGATGCCCTTCTCAGTTCTGCTCAAGACCTGCCTGCGCCCTTCCTCGGGCTTGCTTGCCCAGAATCCTAGCAATGCCCACGGATACTGCCTGGGCATGTGTTTGGCCTCAGCCAAGGTCAGCCTGTCAGGAAGGAAGAAGGGGGAGGGCCACACTTGCCTGGGAGGGTGGAGGAGGAGGGGTCCAAGCCGCCACAGCCTGGCAGTCCTTTTTTGTGCAAAGCAGACCCATCAGCTCCTCTGCCTGGAACACCCCCATTTACTCCTCCGCAGTTAGAGCCGTGCGACGTGAGGAATTTTGTGAGGGGAATTATCTCTGATCTTCATGTGCACATTCCTCGGCAGTATCCCGGGCTTGGCCAGCTTGCTGACACCTGGCTGGAATAACAATGAGCGATGCTTCTGGAGGATGCTCCGCTGGGGAGGGCTCTGCTCAACCAGCACTTACTCCCTGCTTTTCGATCCTCACTCTGCCTTCCTCTCTGACAAAGCCCCGGCTGTTGGGATGGTAATGCCCTCTGGCCTCGCCTTGATTGAAGGTAAAAAATGAACTTCGAGGATAGCCCCTGTGGCTGTGCAGTCTCATTTTTTATGCAGATATGTTGGGGGATGCAGAGACATGGTGGCGGGTGGGGTGGGGAGAAGCCCACTGGGAAATCTGAGACCTGAAGCTAAGATCTGAGATGTCATCCTTTATGGAGCATCTCCGGATGAAAATGTCCCAGACGCCCTACCTCACTCACCCTCTGCCCCCTAATAAAATCACTGTTGCTGCCTCCTGCTGAATCTGAAGTATGCCTTCACTGAGGGCAGGACGTCCATCTCAACTATTATCAAAGGAAAACATAACAAGAGGCAACAGCACAGCCCCCGGGGCATGAGGCTCCTTCCTCTGTGATCCCTCTGTCCTTGTCTGCCAGTCTTTTTTTCCTTGACTTTTAAAATAATCTTTTTCTTATTATGAAATACATATTTATTTTCCTTAACAAAGAATTCTGTAGTCCTTCTAGAAGCTAGGTAACTCTTCTAAGTCCTTTGCAAATATTAAGTCATTTAATTTAATCCTAGAGCAGTTCTGCGAGGTGGTGGGAAGACCTAGAGAGGTTAGGGTCCACCTTAGCACTAGCTCTCTGAGCTATAAGGCCTCAGGGTCTGTGGCATTCCCTACTCACTGAAAAGAAGGGAATTTAAAACATGAGTTCCACCACCCAGAAATGAAACAGTGTTCATTTCCAGAATCCAGGCATATGGTTGATTTTACCAATTTCCTATCACTTGAATCACAGTTTTTTTTGTTTGTTTGTTTTTCTTTGAGATGGAGTCTCACTCTATTGCCCAGGTTGGAGTACAATGGTATGATCTTGGCTCACTACAACCCCGACCTCCTGGGTTCAAGCAATTTTCGTGCCTCAGCTTCCAGAGTAGCTGGGGTTACGGGTGCATGCCACCACACCCAGCTAATTTTTTTGTATTTTTACTAGAGATGGGTTTTCGCCATGTTGGCCAGGCTGGTCTCCAACTCCTGACCTCACGTTATCCACCCTCACATTATCCACCCTCCTACACCTCCCACACTGCTGCGATTACACCTGTGAGTCACTGCACCTGGCCCACAGGTTTTTTTTAATAGTCCTGTGTGTATAATTTTGCATCCTATTATTTCTCCTTCCTTTTAACATATATATATATATATATATACGTATATATATATGTATATACATATATATAATATATGTATATACATATATATATACATATATATGTATACATATATATACATATATATATATATATATGTATGTATTATCTCTTTACTTTTTAAAAGTTTCTCAGACTTTAAGAATTACTTAAAATTTCCCAAAACAAACCCACAGGCACTGCTCTGATCTTCAGGCACACTTTGGTATTCAGGAGTTGCTTCTGCTGGACCAAAGTCAATAACAAGTAGCTTAAGAAGCTGTAGATGGCAGACATAATATTGACTGGAGGCTTACGCCTCTGGTTCAGGGTGGACTCAACAATTTTGCAAGTTCTATATTGTTAAAATTACAATGAATTATTTATAAGCAGTTGTTAGTAAATCATGAAGTTGGCATTATTATTCTTTATTTATTTATTTATTTTGAGATGGAGTCTCGCTCTGTTGCCCAGCCTCAAGCGCAATGGCATGATTTCGCCTCACTGCAACCTCCACCTCCCAGGTTCCAGTGATTCTCCTGCCTCACCCTCCTGAGTAGCTGGGATTACAGGCATGCACCACCACACCCGCCTAATTTTTCTATTTTTAGTAGAGATGGAGTTTCATCATGTTGCCCAGGCTGCTCTCGAACTCCTCACCTCAGGTGATGCACCCACCTCCTCCTCTCAAAGTCCTGGGATTACAGGTGTGAGCCACCACGCTTGCCCTATTTTTTATTATTAAAAAACAAAATGATCCTGATCCTTTCAAATATGTATTGCAGTCTTATTACTTAGTATTGAGCTTTGCAGTGTTGGACTAATATCACAAGTCGAAGGGACAAAGAAGATGGTAGACAATACCAACTGTTTCCCATTAGGCTCTTTCCCTCCTCTTGTTTTTCTGAGACCTTAAGGGCCTGGTTGTTTCTACTGTTCCCTGCTACTTCATAACCTGCAACCTTGAGAATCTTTGTCATTTACAAATTTTACCTTATAGTAGAAGAACATACTAAATAATTGTACCAGATTGAGTAGTGTCCCCCCAAAATTCATGCCTGTATGAACTTCAGAACATGGCATTATTTGGACATAGGGTTTTTGTTTTTGTTTTTGTTTTGAGATGGAGTCTCGCTCTGTCACTCAGGAAGGAGTGCAGTCCCGTGATCTCGGCTTACTGCAACCTCTGCCTCCTGGGTTCAAGCTATTCTCCTGCCTCAGCCGTCCGAGTAGCTCAGATTACACGCACCCGCCACCACGCTTGGCTATTTTTTGTACTTTTAGTAGAGACAGGGTGTCACCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTTCAGTGATCCTCCTGTCTCGGCTTCCCAAAGTGTTGGGGTTACACGCACGAGCCACTGTGCCTGGTGGACATTGGGTCTTTTTAGATGTCATTACTTAAGATGATATCATATTGGATTAGGGTGGGGGCTAAACCCAATCACCCATGTCCTCAGAGGAGAAGAGAGCCACATAGGAAAGAAGGATTTGTAGAGATACAGGGAGAAGGCCATGTGACCACAGAGGCAGAGATTAGAGTGACACAGCTACAAGCCAAGGAGCTCCAAGGATTGCAGGAAGCCACCAGATGCCAGAAAGAGGCAAGGAAGGATCTTTCATGGAGCCTTCAGAGGGAGCACAGTCCCGCTCACACCTTCATCTTGGACATCTAGTCCCCAGAACTCTCAGACACTCCATCTGCTGATGTAAGCCACCCAGTTTGTAGCAATTTGTTATGGCTGCCCTCAGAAACTAAGACAGTAGCCAACACAGAACCAAATACCCTTTGGGGATTGAGGGAAGTGGAGCGGGAGAATGAGCGGCACTCCCTCCCTTTACATAGGACTACTTGGTAAATATTTACTGAATGAAGCAAACCTGAAGTATCTGTACAACTGGCCATTTCATTCTGCATTTAGACCTCTGGGAGCTCTTGAAATGTCTAGACAAACATCCTCTTCAGCTAGAGGAAGCTCCTTCTCCCACTTACTAGCTATGAGATCTTGGGCAGATGGCTTAACATTTCTGGGCCTCAGTGACCTTACTTGCAAAGTTGTCTGGGTCAAGGCAATGATTAAATGCGATGATGCATGTAAAGCCCCAGCATGCAGCCTGAAAATGTCAGCCCTTATTATTTATACTGTTTGCCAAAGTGGTGAGTAGTGTTGCTGAATATGCCGTGTGTCCTATTAACTCTGTGACGGCCACAGTCACGTCTCCTTTCTGCCTCCTCCTCCTCCTCCTCTCTGTCCAGTGACTAGGGACCGCACCAAGTTCAGAGGGTGAAATGCTCAATTAATTCCTCTCCTCCTGCTCTATATTCCAGATCACCCTCTGGGTGGGTTCAAAACCATGCCCTGTCTACCTCCTCTGCAAGGAAAAAATAAAGACAGAGAGCAAATCTAAAACACGCAATGCAGAGGAATGGTTACTGCCTGCTGTGTGCCTCTCCAGGGAGCACCAGGAGGGGCTGTCTGGCACAGGGACACTGCGTATAAGTGACACTCCTCCACATTTTGGCCTGGACTTAGCACATACAACTGCCTTTTTGCTGACGCGATGCCCAGGAGCCCTCTCAGGGGATGGCAAATCTCAGAATAAATGTGTTTTTTACTCATGGAATGCACGGGAATGGATATGAAAACTTTTGTATCAAATAGACATTAGCCAGCAGAGGGATGCTTCACATCCTAGGTTTGTGTGATGTCCGCACAGCTGATCAGGTCTTTCCAAATTTTGCTCCTGAGGAAGGGATGCCCTGGACTCCCAGTGTCCAGGGGCCCTCTGCTTGTCTGTCCTTAGGCAGAGTCCACCAGAATCGGGTAAAGTATGTGACTGCCTCTTAGTGTAGGGCATGACGTCAACTGTGAGGAGAAGAGATCAAGATACAGCTCTTTGGTGGTGTTTTTTGACCCATATCCAGGAACTGTTCCCACACCCAGAGAGGAATATCTGCAAGTTCTGGTGCCAGATGTTGATTCAAAAACAAAACCCAGCGAAGCATCTGTACTTTTTTTTCTGATTGTATTAGAAGTACAGTCCACAATAATATATTGTACATTTAAAAATAACTGGCTGAGCGCAGTGGCTCACGCCTGTAATCCCAGCATTTTGGGAGGCCAAGGCAGGCGGATCCCCTGAGGTCAGGAGTTGGAGACCAACCTGGCCAACATGGCAAAACCCCGTCTCCACTAAAAATACAAAAAAAATTAGCCAGACGTGGTGATGGGCACCTGTAATCCCAGCTATTCTGGAGGCTGAGGCAGGAGAATCACTTGAAGCCGGGAGGCGGAGGTTGCAGTGAGCTGAGATCATGCCATTGCACTCCAGCCTGGGGGACAAGAGTGAGACTCCGTCTCAAAAAAACAAAAACAAAAGAACCCTCAAAAAACTAAAAGAGCCCCCGTGTGGTGGCTCATGCCTGTAATCCCAGCACTTGGAGAGGCCGAGGCAGGCAGATCACTGACGTCAGGAGTTCAAGACCAGCCTGGGTAACATGGTGAAACCTTATCTCCACTAAAAATACAAAAATAGCCGGGCTTGGTGGTGGGTGCCTGTGACCCAAGCTACTCTGGAGGCTGAGGTGGGAGAATCGCTTGAACCCAGGAGGTGGAGATTGCAGTGAGCTGAGATTGCGCCACTGCACTCCAGCCTGGGTGGCAGACACAGTATCCGTCTCAAATAAATAAATAAGTAAATAAGAGTTTAATTGGATTGTTCGTAACACAAAGAAAGGGTAAATCTTTCAGGTGATGGATGCCCCATTTACCCTGAAGGGATTATTATGCATTGTGTGCCTCTATCAAAATATCTCATGTACCCTATAAATATATATGCCTGTGTACCCACAAAAATTAAAAATTAAATAAAAACTTCATTAAAAATAACTTCAAACACTACAGAAATGTTAAAAGTAGAAGTGACCTTTCCGTAGAATGTCATCCCTGTACTTTGGCAGAGAATTTCAATGGAAGCATCCAGAAAACCCTGGCTCGGAATCTGAGCTTGATTATTTCAGTGTTTCAGGTCTCACATGGGGGACAGTCTTGCCACTGTCAAAGGCCATCATGAGAGTTACAGCAGACTTTTGATGAAATTATGTCCACAGTGGTCCCTGGTCCTTTGTGGTTTGAGATATATTCTTTGTCCCCACCCCTGCCCCTTGCTTCACATCTTCTAGGAATCCAGATACATTAAAGCAAAGTGACGGCACAGCCCTGTCCATTTCCTGATCTGTTGCTGACTGTACCACTGAGCTGCTCTCTCCTACTGAGCCCCGCATGGTTCCTCCTGTTTTCCTGCCCTCTCACTTGCTGGTGTTGGCCTGCTCTGGCTGTTCTGCTTGGGGTTAGGTGAGGATATGGGGCAGAAGGCTTCCAGCCTGGAGCGCCTATGGTGTCCCAAGACAAGGGCCTGCCTCTGGCCTCTGGGTGTGTCCTCCTGCGAGTTTTAGAGAAATCTGGGCAGGCTCAGACTGAATGCCTGCTTCTCCTTGCAGCCTTCTGAAGATTCCCATGACACACACCTGATTTACCTTCAGCTCTTTTACTTGCTGGGTAAGCACAGCCCTGGATTACTTGGCATCTGGAATTAACTGAAGGGTAACACTTTCTTAACCTTATTTGCAAAATGAATAGGAAGGAGACCCCTTCTAACTTCTGGAAGCACAAAAGTGTGTTTATCCTTCAGGAGCATTCTTGGCTGCTGAAAAATCATCATGGCTAGCTTTCACTTTCACGTATTGAGCTAGTAGGTGGTATCAATAGTAGCTAATATCTATTTCATGTTTTTTTGTGTAGGAGGGACCCGGCGTGCAATTTGCATGCATTGTCTCATTTTATCCTCCCAGCAGGTAAAAGAGCTGGGAGGCAGTAAAGGGAGTTGTTAATTTCTCACAAGGAAGGTGAAACTTAGGAATGTTAAATACCCCTCTTGGTGTACACAGTATGCAATGGAGGCAGGGTGCAAATGTGCTATGGAGATTTCAGAGCCTGGGCTTCCCAGAGGACGCCTTTGCCCCACAGAATCTTTGCTCCATTTCTCCACTTTGCTGCCTCTATGAATCAATGATTCTGTGTTGTCCATTTTTCCTTTGCAATCTTTTGCCATCTCTTCATTAAAAATGGTCTCCATCATTCTGGCCAAGCACAGTGACTAACATACAATAGGTGTGCAGTAAATGTCTAGTGGATGAATACCCAGTGTCAACATTAATTGAGCACCACTAGCTGCCAAGCAGCCAAGCACCCTATATCTGGGAGATGTAGAATTTAAGGCTCTCTACTCACTGTCCTCAAGCTGCTCACAGCTTTGTGTAAGACACTCAAGGGAACATGCAAAGCTCAGGGCAGCTCAATTTGGGGCGAGGGTTATGGAGAAAATACAGTCTGCATCCTTTTAGTACATGCAGTTCTGCATCTTGGGGTGCAGTGCTAGAGTGAATGACACAGTAGAGGTGACAGGCTTAGCATTTAAATTTGATAATCTCATGATGCCATGGGAGCACTGGAGAAGGGGCACCAGTGGATTCAGCTGACACTCGCAACGCGTTAATGAGAAGATTGGGAAAGGCTGCACAGAGGAGGAGAAGGGCTTTGTAGGATGAGTAGAGGTTCACCAAGGGTGGGTAACAGTTAGAGGAACAGCAGGTACAGAAGCCCACACGAGAATCAGTGAATGACACATCCACCATGTCCAGAGATCAGGGATGGTTGCAGCTGAAGCTAAAAGTGTAAGAGCTTGGACTGTGGATCTTCAATCCCACTTCATCTTATTCCCACCCATATCGCTGGTCCTATCCTTTTCTCACCTGTAACACAACTATGAGACTGGTACCTTCCTAGGAGGGGTGTTGAGAGTCTGAGCCACACTCAAATTCTTGGTGTGCAGTGTCTCTGATCTGAAATGTGCACCGTCAATGTTAGCAGTGGGTATTACCTTTGGCCTGATTGTGAAGCGGGTTTGAGACAGAAGTGAAGCAGTTCAATTTGTTGTGTGATCTTCTTCTTCCCCAAAAGAAGGTTTTCATCCTCCTTAAGGCTTTTGCCCACCCTTCCCTTCCTTCACATCCCTGGTGGGTACCCTTCCCACCTGCAGGAAGCCTACTCATCTTTGAGTTTTGGCCTGCCACCTGCCCCTTCCCTCGCTCTGCAGTCTTGGTTGGCCTCCAGGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGGGTGTGTGGCCCTGGGCTGCACTGTGCCTGCTGGAGCAGGTGCAGTTGCCCTTTCACCATGCGTCCTTCTTTGGATCTGACCCCTTCGGTCCCTCTGTATTTAGAGTCGAGGAACGTCCTCCACTATAATCATCAGAAGTGTCATTGCTAGTTGCACTCAGTTTTCTATGGTGTTTGGGGGAGAAATTGGGGTGCTGGATTTTGGTTTTAACTCTTTCCCACCTTAACCAGTGACTGTGGAAAGTTGCACATCCTCCCCTTCCTCACAGCTGCGGTCTGTTCTTCCTCCGGGTGTTACGGTTTGTGAGAGCCACGAGCCTACACAGAGCTGGCCTGATTTCTGGAGCCATAGCAAGAAGGGAGAGGTGTGTGTCCTCTCTGTCTCTGTCTCTGTCTCTGTCTCTGACTCTGTCTGTCTCTGTCTCTGTCTCTCTCTCTCTCTCTCTCTTCTTTCTCCCTCTCCCTTTTTCACATGTTGTTTTCTGATTATAAGAGGAATACTTCATCATTAGACATATTTCGAGCCTCCGTTCCTCATCTATGAAATAAGCATAGTAAAGGACTGAAGGATTTAAAGGGATGTGGCCAAGTGTGCAAAGTCATATCTGCTCAATAATTTATTTTCCTTGTTTTCTTTTCCATTTCCTTCTTCTCCTCTAAGCCCCTCCACATCTCCGTGATATAGCCTGTACTCCTTTCCTCATTTTCTTTTCTCTGACACAAACCGAAGTTCCTACTTCTGCTATTTCCTAGTTCAGTCACCTTGGACAAGGCACCCTGGGGAGCCTTACCTGCTCATATGCACAAGCTTCTACCAACTGCTTCCAAGGGAAGCGTGGGCAGGAAGGGAGACCCTGAGTGTTTGGACCCCGCCTGTGCTCAGCACAGAATGCAGCTCAGTAACGGCAGGTCGTCCGCTCCTTCTTCTCCCTTTCAGCAACCATCACTCGTATTCTTTTTTATCTCCAAGGCCTCATGCTGGAAACAGATTCATTGCTCTCTGAGCAGTAAGTCCTCTGAAACAGGGTTTCTCTGCGGAGTTCTGTGGCACCCCTGCCTTACCTGGGGGACCTGCCAAAGAGGCACCCTCCACCCCCCCTCACCCTCAGCCAGGTTTACTGAACAGAGTTACGGGGGTGGGCCTCCGGATCTGCATTGGAGCAAGTCCACAGGTGCTGCTTAGGCACACTCACCTTTGAGAGCCACTCACCTAGACGGGAAGACTGGGAGAAGCCTTTTAACACACCACTACTGTGACTTGCACCATGGAGACACCTGGAAAACATACAGTGATTCACACACACGCCCCAAACAGCAGTGTGTGTGTGTGTGTGTGTCTGTGTATGTGTGGTTTCACACTTGGTTTGCTATGAATGCTCTAATGCCACCCAGTTCCCACAGAGCTCTGGCGACTCAGCTTCCCCAAGTCAGGGTTCTTTTCTGGAGTCCTATTCTGACAGGTTTTTATTTTTATTTTTTTAATTATTTTATTTTATTTTTATTTTATTAGTATTATTATATCTGACACGTTTTTAATACAGTGAATTTGTATGTCTCCTGTGTATTTATTTTAGCTGCTCCCTTCTTTCCCCTTCTCTCCCTTTCCTCTCATCTCCTCCCGCTTTCGTCCTTTACCTTTCCCTCCATGATATTACCATTACCCGTACACTCTTCCCATCTCCTGGCCCCTCCAGTTCTGAAGGCATCGGCACTAAGTGGGATCTGTCCTCTAAGCAGGCGGAGGAGGGAACCATGTCAGCTCCTAGGTGCCCCCAGAGCACCTGCTGCCAGTTTTCCACAACTCCTGTCCTCCGTGGCGCTTGGGTGACAGCAGAGCAGAGCCGATGTGCCTGCTCCTGGTCATGGGCTGTTCGTGCTGTCATCGCTTTCATTTGCCCCATCCCCCCAATTTGGACTTACCCAGAATCCTTGGGCAACCTACATCGCTGCCAAAGTTTACTTAGCGAGATGTGCCTGCGTGACTTGAGTAGAGACCTGCTTCTGAGAAAGTCAGAAGTGCATTCCAAAGTCAGGAGCGTGACCTCCCCGGAAGCCCAGCTAATCCAGGTTTTAAAGAGGAGTTGCAACAAAGGTGGTGCTTATGGGATGTATGGAGCTGTGaGATCTGCCACAGGACAGGTTTAGCAGAGTGGCGTGGTGGAAAGTTTCCTCTCGCCGAGGAGGACAACTCCCCAGCGCCTGAGACAGCGGGAGCTCAGAGCGCCTAGAATGTGCCCAGATTCTAAAGTGAAGCAGGCTGTGGTGTGATGATGGCCCCCGACGGCACTTGCAGTCTTATGGACCTGGGTTCAACCCCACCCTCTTCAGCCACACAAACTGGGCAAGGGGCCCGCCCTTTTCACGCTGCTGTTTCTGTAACTTTCAGATATGAGACCTGTCTGTGGGGTTGTGAGGATACATGGGGATTAAGTGGGAAATTAAAAGGGTTTTCTTTGTGACTGGTGACTGATAAATGCCATTTCCTTTCATCCTCCTTATTTTGACATTAGCCCCAACCTCTACCCCGAGGGTCTCTCTCTCTCTCTTCCCAACTTAGATTCCTCTCAGCGCACACATAGACAACCCAGAAAAGCAGCTCTGATCTCTCGTGGAGCTTCCCTGAACTCCACACCGCACATCTACTACTGTTTAGGATAACATTTTGACTTAGTCCTTAAACGGACTATTTCTCATAGTCCTGTTTTGTAAATCACATTTTAACCTCTTTGCAGACAGGGACCAGTATAAACTCTTGAGTCTCTGTCAAACTTAGTGAACTTTCTTTCCAGCCTGGGCAACATGATGAAAACCTCTCTCTACAAAAAAAATACAAAAATTAGCAGGGCATGGTGGCTCGCACCCGTAGTCCCAGCTACTCTGGAGGCTGAGGTCGGAGAATTGCTTGAGCCTGGGAGTTTGAGGCTGCAGTGAGCCATGATCACGCCACTGCACTCCACCCTGGGTGACAGAACCGGACTCTGTCTCAAAAAAACAACAACCCCCCTCCCCCACAAAAAACCTTACTGAACTTTCTTGGAGAACATGCACACTGTAGAACCTTCTGTATTTGGAATATTCAAGTGCAGGTCCTGCTGTTCTGTAAAGAACTGTCACCTTGAGTCATTGTTTGACGGCTCAGGTCCTTGGCACTTTACCCCTTTGTTCATGATTGATTGACATTTGGACCTTTGCTGACCTTTCCCTGACGCATTTTCTGGGCATAGTCAAACAAAAGGAAATTGAAAAAAAAAACCCCACAAATTTTGAAGGTCTGTCACTTGGAGAAGAACAGTGTTCATGACTCTTCTTCGTCATTTCAGCATCTTAATCATCTTGAGCCTAAAGATGAACCAGAGTGGAGGTGAGCCTGATTAAATGGGAGCTTTTCCTATATTGAGGATCTACTACGTGCAACGACCTCACTTGGGTTATCTCTAGCCTTCCCCCAACTCTGCAAGGCATTTCACAGATATGGATGCAGGTTCAAAGAACTGAAGCTTAAAGCTTCGCAGATTTGGAAGCCTCAGAGCTAGAATTCTCCCCCTAGCCTGTTTGTCTCTGAAGCGTTGGTTATTGCTTGACATTGCATCCCTCCCTCTTTTTTCCCTCTCTTCCTCTTTCCCTTCCCTGCCACTGTCTGCCTGTCTTCCTGTCTCCCTCTCTTTCTGTCTTAAAATTACTGTTGCTATTCCTTACTGGTCTGGTCTGGTCTAGTTAATTAAAAAGAAGGCTATCGTGAGGTAACCCTGGGATCCTTATTGGCACAGTCATATTCCCATAACTTTTAGGTGCCTGAGTCCTAATGGATCTGTAAGACAGTGCCCATCAGCGAGAAATACCCACAGCCTCCCTGGATGCTGCCCACAGGCATCTTGCAGATGAGGGTGTTTGCCTTCTCACCTGCAAGGGGGTGGGGAGAAGTGGCCAGCCGTCGCCTGTTCTGGGGACGCCTGCCTCCCCACTCCCTGAGCCTAGGGGGAATGATATTATGGCTTCAGGCCACAACTAGACACATTATCTACTCTGACAGGGAGCCAGTCTGGAGAAGGATGTCATGGATGACGTGAAGAAATTACTGAGGGAAAAAGAGCAAGGCGTGAGCCCTATTGGGGCTGTTTTGGTCAACTCCTGGCACTAGATGATATTGATGCTTTGGAAATCTCTATTTTCCTTCCATTTCCCAGCAAAGTGCCATTCCCATCTCTTTCTTTTAGAAGCTTCTTATCCTATGGCTCTGCCTCCAGTCTTTCTCATCACATAATTCTTCAAAGGCAAGGCAGACTAGTGGTTAAGAACAAAGACCCAGGGCTGGGCGTGGTGGCTCCTGCCTGTAATCCCAGCACTTCGGCAGGCCAAGGCCGGGGTATCAGTTGAGCTCAGCACTTGGAGCCCAGCTTTGCCAACATGGTGAAACCCTGTCTCTGCTAAAAATACAAAAATTAGCCGGGCGTGGTGGCAGGTGCCTGTAATCCTAGCTACTTGGGAGGCTGAGGCAGGAGAATCACTTGAACCCAGGAGGTGGAGGTTGTAGTGAGCTGAGATCACGCCACTGCACTCCAGCCTGGGTGACAGAGCAAGACTCTATCTCAATTAAACAAAACAAAACAAAACAAACAAACAAAAAAGAACAAAGTCTCCCGAGGCAGTGCCTGGGCTCGTATCCTAGCTCTGTCTCTTGCTGACTCCTGCATGGCTTGGGCATACTTGGGCTTTGCTGTGCACCAGTGTTCTCGTTTCTTAGTGACTTCGTATCTCACAGCATTGTTGGAGATTACAGGAACACAACCAATGCTCTCAGAACCACCACTCAGGAAGTGTGGTAATTACATGCTCTTCTGGGCTTCTGGTCATGCCACCTTCGACGGACAATCCGCCAGCACCCACCACTTTAAGGACCAGTTCCTCCTCTAGGCATTGTGCCCAGCGCACCCTTCTCATGGAGATTTGCTTCTCACTCTGCATCTGCAGGTCTTCGCTGGGTGATCTTGGGCAAGTCACTTTACTTCTCCAGGCCTTACTTCTCAGCTCTTCAGTGAGGACATTGAACGAGATTATTTCCAAGGTTTCTTGTGTCCTGACGTACTGCGGCCTCTCACATTCTATGTGGTCCAACCTTTCCTCCTGTTCCTCAGCTTCTGCCAGCCCGCCACGGCAACCTGGTTATCAACAAATGTCCTCGCTTATGGACATGTCCTGCTTCTCTGGAAATCTTACTACACCCTGAAAGCTCCATGAAGTCAGGATTGTGTCTTTCATGTTTGATATGATTTCTGGCTTCTAGCACTGTGCTAGGAGCTAGCACGTGAACACTGTCTGTGTAGCTGGAATTAATCACCCACTATTCCAGTCAACAATTCCTTTTTTTTTTGAGACGGAGTCTTGCTCTGTCCCCCAGGCTGGAGTGCAGTGGCATGATCTTGGCTCACTGCAACCTCCACTTCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCTCACTAGCTGGGACTACAGGCGCTCGCCACCACGCCCGGCTAATTTTTTTTTTTTTGTATTTTTAGTAGAGGTGGGGTTTCACTGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTCATGATCCGCCTGTCTCGGTCTCCCAAAGTGCTGGGATTATAGGCATGAGCCATCGCCCCCGGCCCTTTTTTTTTTTTTTTTTTTCCGAGATGGAGTCTCACTCTGTCTCCCAGGCTGGAGTGCAGTGGCATGATCACTGCTCATTGCAACTTCCGCCTGCTGGGTTCAACCAATTATCCTCCCTTACCCTCCCGACTACCTGCGACTATAGGCGTGCACCACCATGACTGGCTAATTTTTTGTACTTTAGTAGAGACGGGGTTTTGCCATGCTGGCCAGGCTGGTCTTGAACTCCTGACCTCGTGATCCACACGCCTCAGCCTCCCAACGTGCTGGGATTACAGGCGTGAGCCACTGCGCTCAGCTTTCCAGTCATTTCTTAAGCGATGTTCAGTTCCCAAGCACTGTGCCCGACACGCATGGGTTGCTGGACGCTGGCAGAACCCGAATGTCAGTATTCCTGAAGAATGGCTCTAAGCAATGTACCTTGCAGAGCTCAAGCAGGGCTCTGCTGCATCATGCCCATGAAGGTGCCTGCTGGTAGAAGGCTGGTTCTATACTGGCTGCTTGCCTCCTCCTTGTGGAGACCCACATTGTGTCTCCCAAAGTGCAGAAGGAAATCAAGCCCTTAATAACATTAGGGAACTGGACTGGGTTCGGTTTGCATCTCCCGAGTCTGACTCGTCGGAGTAACCACCATAATAGCAGCGCTGTGCTGTTGAGGGTGACTTTGACTATCTGCTTCTCTTGTGAGCCCACTGTGTGCCGGAGCACTCTCTATACATTCAGTCTTGTCCGCAGATGAACTCCAGTGGACACATGTTTCTATTCCTTATTATTATTATTATCATTTGTTTTTCTGAGATAATAATAATAATATTATTATTAATATTATTGTTATTATATTATTATTATTATTATTATTATTATTATTTAGATGCAGTTTCACTCTTGTCGCCCAGGTTGGACTGCAGTCGCACAATCACAATCTCAGCTCACTGCAACCTCCGCCTTCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGAGATTACAGGTGCCCGCCACCACACTCAGCTAATTTTTGTATTTTTGGTAGCGATGGAGTTTCAACATGTTAGTTACCCCGGTCTCGAACTTCTGACCTTAGGTGATCCACTTGCCTTGGCCTCCCAAAGTCCTGCCATCACAGGTGTGAGCCACCACACCCGGCCTATTATTATTATTTTTTGAGACAGGGTCTTACTTTGTCACCTAGGCTGTTGCCTCACTGCAACCTCCACTGACTTCCTGGACTCAAGGAATCCTCTTACCTCAGCCTCCTGAGTAGCTGGGACTACACGTCCGCCACCACTGCCACCTAATTTTTGTATTTTTTGTAGAGATATGCTTTCACCATGTTGTCCACGCTCGTCTCAAACTCCTGGCTTCAAGTGATCTCCCCGCCTCCACCTTCCAAAGTCCTACGATTACACGCATGAGCCGCTGTGCCCGCCTTATTCTTTGTTTTATTGAACAGATGAGGAAACACTTTCAATGAGCTTAAGGGATGTGCCCAAGGCCACACGGTTGTGACCACAGCATGAGGATTCACACCTTGGTTCCTGTGGCTCCCATCCCCCCTCCCCTGAATCAGCAATCGCGTGAGTGTGACGGGAGCAGGCACTCCAACCCTTGGGAATTCCAAAGCAGCTGATCCATGTCATCCCAGCACACGTTAGCGACGAACTGAAACCAAGCAAAAATAGAGCCTGTCAGCGCGGGGACAGCTGCCGCTTTCTCTGGGAACAGATCTCCCCCATTTATCTTCCAGGTTAGGAAACCCCCAGCTCCTGGCGTACCACAGAGAAATAATGTGAGCACAGCCAGAGAAATTGCCACCTCTCCCTTCCTCAGAAGAAGATAAAGGAGACATCGTCTTTTTGGCATCAGTTTTGAAGAAATCTTTTTTTTTTTTTGAGATCCAGTCTCCCTCCTGTTGCCCAGCCTGGACTCCAATCGCACAATCTCCGCTCACTGCAACCTCCCCCTCCCAGGTTCAAGCGATTCTCCTGACTCAGCCTCCCACGTAGCTGGGATTACAGGTGCCCGCCACCACGCCCAGCTAATTTTTGTATTTTTAGTACAGAGGGGCTTTCGCCATGTTGCCCAGTCTCCTCTCGAACTCATGACCTCAGGTCATCCACCTCCTCGGCCTCCCAAAGTGCTCCCATTACACCCGTGAGCCACCACACCCAGCCACTTTTGAACAAATCTTACTTCACAATCCTCACAGAAAGAGAAATTGAGGCACACTTAGCATGTGAGACTGATTTCTCACTTCTGCTGCTACAACTGCTGCCCCATTGACCGGGTCTCAGAGGTGTTATAATTAACATCCTCTGACTCTTGCTGGTACTAAAATTAACAACATGACTGGTCCCTTCTGCAAGACAGGGAAAGAGATACACACATGTGCACATACACGCACACACATGCCTGCACACACACACTTGCACGCACACATGCATGCACACACATCACACACACACACACACACACACACACAGACACATGCACAGTCCAGAACGCTCACAGACAGAGAGAGAGAGACGAACGCACAGCCACACACACACTCCCAGACACTTATTATGGCTCCCCCTGCAAACGGTGCTCCCCTCAAAGCTTTAGGACCAGGGACGCCTTCCCTCACTTTCTGTGTTCTGTACCTCATACCCCATTTACCAGCCTGTCCCAACCCTGTATACTTTAAGTCTTCAGTTACCAAAGCATCCATCTGCCCGTCCTATATTGAGGGGGAGTGGATGCGCAGAGGTGGTCTGTTGGTGTTGCGTACGCAATAGACGCACCCTGTTTTTCGTTTTTCTTCCAAATGTCTTCGGCAGGGCCTCACCTAGTGCAAATACCTGGTGGGGAGGGTCAAGAAGGAAATGACAGTGGGGGGAATGGGGAGGGATAGCATTACGAGATATACCTAATGTTAAATGACGAGTTAATGGGTGTAGCACACAAGCATGGCACATGTATACATATGTAACAAACCTGCACGTTGTGCACATGTACCCTAAAACTTAAAGTATAATAAAAAAAAATAAAATTAAAAAAATAAAATAAAAAAAGAATTCCTATTTTAACTTTGGAAAAAAAGAAAAAAAGAAGGAAATGACAGATTTGGTCCTGACAGCCTGGGACGCAGAGAGGAGAGAGATGGAGCCAAGAGAATGCGGCTGGGGCCACGTTTTCTTGTGGCGCAATTCCGTGTCACTGGGCCAGAGCATGCTTATTGTGAAGACTTCCCCTCAGTGTCCTCTGGGCAAGGCTCACCTGTGAGGCAGTCGCCCGTCAGAATACCATCAAACACGGAAACCTGGAAGCTGCCGATTCCCAGGCCTTGAAGGGGTGTTCTGATGTCTTTGACATTCCAGCAAACATATTTTCACAGGAAAACTCAAAAAATATAAACTCCCTTTTTATAGAAATAATGTGCATGGAGAAAAGTGCACATGTCATATGTGTATCGATAGCTTGACGAATGTTCTCAAACTCAACCTGAGTGTGGAGCCAGCACCTGGATCAATAGAACATTTCCAGCATTTTGGAAGCCCCCTCCCAGTCAGTCACTCAGGAGAACTTTGTCCTGACTTCTAACCACACAGATTAGTTTAACCTGTTTATGTACTTAATCTAAATAACATCATCACACACTCCCCTGTGTCTTGCTTCTTTCACTCAAAATTATGTTTGTCGGATATATTCATGTGCTACCTGCATTTTCAGATCATTCTCACTGGTCGCTAGATTGTGTGCATATTTTAAAAAATCCATTCTACTGTTGATGGGCATTTGAGTAGTTTCCAGTGTTTGGCTGTTATGAATAGAGCTGCTGTGATATCCTTAGACTTGTCTTCTGGTGAACATATGCACACATATCTGTGCATTGATACCACGGAGTGGAGCTGCAGGGTCATAGGGTTTGGGTATATTCAGCATTAGTAAATAGTGCAGAACAGTTTCCCAAAGTGGTTGTTTATCCTTTTTCAGAGTGTCTGTTCACCAGCACGTATGAATTCCAGTTCCACATCAAAGCCAATTATTGGCATTGTGTGGTTTTTAAATTTTAGCCAACCCATTACAGAAAGAGCAAATGAAAGGAATCTAACAGCAAGTAATCAGGAGAGAAAAGAAAATGCTCCCTGAGAAAGCATTATGATTTCATGATACGCCAAATCCCGGTGTACAATGCCACACATTGTGTACTTTTGCAGGCGGAGGGCGAGGTGCAGCCACCTTCTTGTGAGCATCAGGGCAGTCCTTGCCATTGGTCAGGGACCACCACTTGACTGCAGTAATACCCAACAGACCATGTCATAATTCTTCCTCAGGTGACAGAGCTTTAATGGATCCGACCCCAACAGAACAAACTTGGCTTCAGACTTGCCTGTGGGCCTCAGTAAATATTCAACAGACTGTGTCCCCCTGTTCACTCCCCTGTCATTAGCTGACGCTGCTACCATAAATCACAGCTCCCCTTCCTGTTGTAAGTGGCCCCTCTCAGCTGACGGTACTCCAGTCCTGACATTCAGGAGCAGTGCCTCTCCTGGGCTGCTTCCCAGGGCTGGCAGGTCTTGGTGGTCACTTGTAGGAGCCGAGGACTGAGTCTGTGCAGTCCTGGAGTCACTGCTGTGGGGTGACTTCCAGGAGCCTCTTCCATTTGATGTGAGAATGATAGATCCGTCAAGCTCTTAATATGTGCCCAGCAACATGCTAAGTCCTTTATGTTGTTTATTGCAACCTGTCACAGTCCATTCAGGCTGGTATAACAAACCACCTTAGACTGGTAGCTTGTAAACAACAGAACTTTATTTGTCATGGTTCTGGACGTGGGCAAGTCCAACATTAAGGCTCACACATATTTGGTGTCTGGTGAGGGCCTGTTTCCTGGTTTAGCAATGATGCCTTCTTGTTGGGTCTTTATATGGTGAAAGGATCAAATAAGGTATTTTATACCTCTTTTATAAGGGCACTAAGCCCTCCAGCCTCATGACCGAATCACTTTTCAAAGGCCTCCCCTTTTGAGATCATCACCTTGGCAGTTAAGAGTTCAACGTATGAATTTAGGGGTCGGGGGTGTAGGTAACAAACATTCAAAACATCATACAACCTCACACTACTTCTATGAAATGAGTAGATGTTCTTTACCACCATTTTCAGATGAGGAAATTAAGCGTTAAAAACATTTCCCCAGAGTAAGAAACGTAGTAAATTTGGGAGTCTAACTTCAAACTGTAATTTTTAATTACTGTACTTCCTTCTTCTTTTCTCTTAGGCGCTGTTTAGATACTTGAGCTTCCTTTTGAAGCCATCTTCCTCTTCGGTCTAAAAGCTTTCAGGTAGATTTAAATGGGACAACAAGGCCAGATGCAGTGGCTAACACCTCTAATCCCACCTATTTGGGAGGCTGAGGCAGGAGAATCACTTGAACCTGGGAGGTGGAAGTTGCAGTGAGCTGAGATGGCACCCTTCCACTCCAGCCTCCGCAACAGAGCAAGACTCTGTCTCAAGGAAAAAATAAATAAAATAAATAAATAAATAAATGGGACAAGAGGAAGTCACCTCCAGACCACATATTCCGTTCACATGTAATTATCTGCTTTTTCAATGATTTTAACAAATTAGAACCACTGTTTTTCTCTGGCTCTTTTCATGACTTTTTTCAAATGTTGGTTTTCAGCAGTTCAACTATTATATACTTAGGTGTGATTTAAAAAAATATATATCCTGCATGGGATTTGCTGATATTCTTATATCTATAAATTAATGTCTTTCACTGAATTTAGAACACTTTCATCCCTTCCCACCCCCGATATTGATCTTGCTCCATTCTCTTCTCTCCTTTTGGGACTAAAATTACATGTCTGTTAGGCTTTTTGATATTGTCCTACAGGTCTCTCAGGCTCTCTTCAATTTTTCAAATTTTTTTCTGTTATTCAGATTAAATAATTTCTATTGGCCTCTCCTCAAATTGTACTGACTCTTGGTTCCTCTTCAGTCTGCCGTTAAATGGATCCAATTGATTGTTTCAGATTTTTTTTTTAATTGTAGAATTTCCATTTGGCTCTTTCTTTGCTAAGCTTTCTTATCTTTTTATTTACTAAGAATACATTTTCCTTTGAGTCTTTGAGCATAGTTATAATAGCTGCTTAAAAAACCCTTGTCTCCTAATTCCAGAAACTGGGTCATCTCAGGATCATGGGGACGCTCCCCATAACTATCTTTTTTCTTAAGAATGGATTACATTTCCTGTTTTTGTTTTCTTTTTAGTTGTTTGTTATATTGAGCTATTATAAATTATATCACACACATTGTGAGTGATACTTCGTAAGGACTGATTCTGTTTTGTTCCTCCAAAGAGTAGTGCTTTTTTGTTTCAGTAGGTAGTTAATTCAGTAATCTAAGACTTCAAATTCTGACTCCCTAGTATTCGCCAGCAATATAAATTGCTGTTTAGTTCTTTTCGCTTTAACTCGGCTACTCCATACAAACTTGGCTCAGGAGTCACTTAGTGACTTAGGGAACATTTGTACACAGAATTTGAACTCCCCTTTTTGGAAACTCTCTTTTTACCAGGATTTCTTCTTTCACTTTCACCTATTGTGTTGCCTTGATCTCTGTCCTGATGTTTCAGTGCAGCAACACCATCTGAGTGTTAGCCACTCACATGTTGCAGAACCGGGCCTACTCTCAGACTAAAATTGACCAAAAGCACCAACTCACTCGCTTGCTGAATGTCCAGGTCTTGATCACACTCCAGAATGTCCTACTTTTGGTCATCAGGTGCCTAGATTTTTTAGAAATCTTTGTTCTAATTTTTACAAATATTTGTTCAGAGTTTATAGTTGCTATCTACCAGGGAACTGCTTCAATAGGAACTACTCAACCATTGCCAGAACCTTCTTGAACTTTCTAGAAACACTGTCTTATTTATTTTATTTTATTTTTTAGACAAAATCTCACTCTGTGCTCTGCCACCCAGGCTGGCGTGCAATGGTGTAATCTTGGTTCACTGCAACCTCCACCTCCCGAGTTCAAGTGATTCTCGTTCCTCAGCCTCCCAGGTAGCTGGGATTACAGGCACCTGCCACCACACCTGGCTAATTGTTTGTATTTTTAGTAGAGACGGGGTTTCACCACGTTGCCCAGTCTCGTCTCAAACTCCTGACTTCAGGCGATCCACCCATCTCAGCCTCCCAAAGTGCTGGGATTTACAGGCATGAGCCACCACGCTTGGCCTAGAAACACTGTCTTATTTAAATAAGAAAGAGTCTCTCTCAGAATGGAAAGAAAACACCTTTCGAGTCAAACCCAACTTGGATGCAGAATCTCACTCTATCTTGGTTTTTTTTTTTTTTTTTTTTTTTTTTTGAGACTCAATCTCACTCTGTCACCTAGGCTAGAGTGCAGTGGCATGATCTTGGCTCACTACAACCTCGGCCTCCTGGGTTCAAGCCATTCTTCTGCCTTAGCCTCCTGAGTAGCTGTGATTACAGGTGTGTGCCACCACGCCTGGCTGATTTTTTGTAATTTTAGTAGAGACGGGGTTTCACCGTGTTAGCCAGGATGATCTCGATCTCCTGACCTCGTGATCCACCCGCCTCCCCCTCCCAAACTCCTGGGATTACACGCCTGAGCCACCGCACTCCGCTGCATATGTTTTTTAAGAAGAAAACGTACCTTACTGTTTCCTTCCTGATTTCTTCACTAGCCGCTGCAAGTGTGTGTGGCTCTGTGCATTGTCCGCAGGGTCACGTACCTACCTTGATTTCCATTTTGGCAATGAGTGGTGCCTCCTCATGCAAGACTTCTTAAAACAGCAGATCGGTGCCCTCTCTTATTCTTGTATCGCAGCCAGAATAACCTCCCCCTAAATGTCCACATCCGAATCCCTAGAACCTGCGAATATGTTGCATGTCAAAAGGGACTTTGCAGATGCTAGTAACGCTAAGCACCCTCACGTGCACCCATCATTTTGGATCATCTCCGTGAGCCCAATATAATCACATGCGTCCTTAGGACTCGAACAGGGAGGCAGAGAGTTATTCAGAGACAGAGATATGGCCACAGAAGCAGACTCACACATGCCTTGGTGTTGTATTTGAAGATGGAGGAAGAAGCCACAGCCAAGGCCTATGAAGCAGCCTTTAGAAGCTTCCAAAACCAACCAAACACATTCCCTCTCAGCCACCAGAAAGAAATGCAGCCCTCCCAACAGCCTGATTTTAGCTCAGTGAGACCCATGTCAGACTTCCAGAAATGTAAGATCATAAGTGTGTGCTCTTTTATTTTTTATTTCTTTTTCTGTTTTAAACCACTACGTTTGTAAACATTTCTTTGGCAGTAATCGTTGCTTTTGATGGAAGTTGGAGCAGTGGTCAACCTCGTCCCCTTTGGAGCCAGTCTCCCACTCCGCCTTCTTTCAAACCCCTTTTCCTTTCTCTCTTTCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCCTCCTTCCTTCCCTCTCTCTCTTTCTTTCTTTCTTCTTTTTTTTTTTGAGATAGAGTCTCATTCTGTGGCCCAGGCTCGAATGCAGTGGTGTGATCTTGGCTCACTGCAACCTCCGTCTCCTTGGTTTAAGCCATTCTCATTCCTCGCCCTCCCAAATACCTGGAATTACACGCATGCACCACCACACCCAGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGGCCAGGCTGGTCTTGAATTCCTGGCCTCAAGGGATCCACCAGCCTCGGCATCACAAAGTCCTAGGATTACAGGCGTGAGCCACCGCCCCCAGCCTCAAACCCTTTTCCTGTGATTTTTTTTTTTTTTTTTAAAGCTGTGTGACCTTGTGCAAGTTGCTTCACTTCTCTGGCCCTCAAATTTCTCATCTCTAAAGTCGGTTAACAATAATCTACAACTCATAGTTTTTTGTGAGGATGAAATGAGGGTTTCATACATGCAGAAAGCCTGGAAGTAAGTTTTAGCTGTGGCCATTCTGGGCAGGAATCCCTCACTACGTAACTTAGAGCGGCGGATCAGGGCACAGACTTGGGACACAGACTCTCTAGCTTCAGATTTAGGCTTCTTACTAGTCTGAAGTAGAATGGTTGTCTGTTCCTCCACTGCTTCATCTGGAAAACAGGGGCAGGCATCCCAGGGTGTTTGAGAGATCATATCAGATGGAGAGGCCAGAGTTTTTAGCCGATACATCATAGACATTCCCCAAAGGACAGTTATTGTTATCATTCGGTGGATGGGGAATATTGAGCCTCCAGCCCTAGGCATTGTGGATCAATTTGTTCTTCAGTTATCTTTGGAATAATTTAAATACACTGGATTGGGAAGACAAAGCTATCACCCTCCTGATGGGAGAGTGCTGGGTACCTAGCAGGTGCTCAGTAGTTAGTGAATGAATGAGTAAGAACACAACACGTCCTAGGCCCTGCCCTGAACAGGCTCACAGTCCACCACAAGGCCTGGAGTCAGGCCAGGGTTTTGTGGTTGTCTTTAAAAAGAAACAAAACAAAGAACTACTTCCTACCAGCTGACCCTAAACCCCTCAGCTCCCTGCAGGGACCTCTCAGCCCTGCAGGGGAGCCCAGGCTATGTGCCAGGCCTGGCCTTCCTGTCAGCTTTCTAAGCCAGTCACAAACATTCTCCTCTCAACTTTATAATGGATGCCCCCCACCCTCCTCTCCCCTCTCAGGGTGCTCCTGAGGCTATGAGCAGCTGGCAGTTCCCTGTCTGAGAGGTCCTTCGTACCGCAGGAGAGGCAGCTCTCACCTGAAGGCCTCCCTGGACACCGGTCTCAACTTTGTGTGTTACCAGTTATGGAGAATTATTTTTAGTGAGTTACACTCTGTTAGGGCCAAACACAACGAGCAAAGAGTCACTGAATACTGCTCTGACTCAGTGACTGTGACAAGACTGTTTTTTTCTTCTTCCCTGTTGCAGGCCTGATCTTTTGGCCAGAAGGAGATTAAAAAGATGCCCCTCAAGATGGCTGTGCCTGTCAGCTGCATGGAGCTTCGTTCAAGTATTTTCTGAGCCTGATGGATTTACAGTGATCTTCAGTCGTCTGGCGAATAACGCTGGTGGAACCATGCACTGGAATGACACACGCCCGGCACATTTCAGGATACTAAAAGTGGTTTTAAGGGAGGCTGTGGCTGAATGCCTCATGGATTCTTACAGCTTGGATGTCCATGGGGGACGAAGGACTGCAGCTGGCTGAGAGGGTTGAGATCTCTGTTTACTTAGATCTCTGCCAACTTCCTTTGGGTCTCCCTATGGAATGTAAGACCCCGACTCTTCCTGCTGAAGCATCTGATGCACGTTCCATCCGGCGCTCAGCTGGGCTTGACCTGAGGCTGTCCTCCCTGCTCACGGAGGGTTCACTGGGATGTGGCTGGTGTTCTCAACGAGGTGGCATTTAATGAGCACCCTCTGTGTGGTTGGCGTGATGCTGGGTGCCTGGGGGAGACAGATGGAACTAAAGAGGTCCTTCCTGGAAGCCGTTACTGTTCCCTGCCCTGACGTGTGTTATTGTACCTGTCACCATTTTCTGATGTTCCCAGTTTACGTATCTGTCACCATCTACCTCCCTATAAAGTCCCTCTCCTGTTGGTTCTGTGTCCTTAAGACATTGTGTGGCATTTGGCACAGTCTCTCATGCTGCAGAAAGGGThAATTAAGACAGGATTGTTAATGAATGAAGACATGGGAGATTCAATGGAAAGATATGCATGGGGGGATAATTTCTTGGCTCTGTGCTCAGAGCTAGGAACAACATAAGCCCATATGCCTGGTGCTGTGAGGGTTGTATGTGGGCAGATCCATGTCGACCCAGACAGGCCTCGGTATCACTCTTTAACACATACACACTCCATGCCTCCAGGCAGACTGATGGATTCCTTTCCCTGCAGTGAAGGGTTAAGTATTATCACACGTCACAGGACTGGAATTGAAGATCGCCAAGTAGACATTGAAATGCTGACCACATGACAGACACTCAGCATGTGGTGGGTGATGTTGGCTGCGGGTAGCTTTTGGGGATGGTGGACATTTCTTGGCCCTGATCTTTCTGAGCAGAGCCAGGGAGGCAGTGCTGCACTCTGACCTGGGCACAGCTGGTTGGCGTGGACAGTTGATTAAAGGTCACAGTTTCCCTGCAGCCCATGGGAAGGCAGAGTGACAAGTCAGTGGCAGATGAGGAAATGGAGTCTCATGCCAGCTGGAGGGAGGGAGCAGCTGGGTTGGCCACAAAGGCCTGTTGCAGTTCTGCAGCTGACAAGTCGAAGCACTGGCCTCTCAGGTCCAGGCCTGCTGCCCTGCGACCCTCCTAGCTCTGAGCGATGAGTGGTGCCAAGGTGCCTGAAGGAGAGTTGCAGCTCAAACAGCAAGTGGTCCAGCTCTCAGACCACTTGAGGCCACCTGGCATGTGGCGGCCAAGACCACAGTTGGGGCGGGGCCTTGAGTCTGATTTTGATTGGATTCCTAGTTCGGCTCATGCCTGACAGCACTTTCTCAGACAGGCTTCCCTGACCTCCTAAGGTAAATAATGTCCCTCTGGGTGTTACATGCTGTTCTCACCCATAGCTCTTAGATGTGTTCTAATTGTATATTCATATGTGCAATTTACTGGGTTTCCTCTCTTTCTCTCACACTAGAAAGTAATCTTTCTGAGTTGAGGAAATGCATTTGCCTTGCACACAGGCTAGACACATACATAGTAGGCATTTTATTTGTTGCATCACAGTTGCCTTCATCAAATATGGTGACTCTCCCTGGTTTTCTCTTGGTTTCTTTGAAAAGGTCAGACAGAAGGGAAACACTCTTTTCTTGAGTATATATATGACTTAGCCCAGCAATCCCACTAGGAGAGCAATGGTTTATCCATTATACAGTTGAGCGCCTGGAGGCTCTGAGGGGCCATGTACCTTCCCCAAGGTTATTTATCCAGGAGAAGACACACCCAGAACCTCACAACTGCCTCGTGTTTTATACCAAACAAGGCCCCTTCAGCTGAAGACTTTTCCTTGCGGTCTTGGGAAGGGTGTGTGTGACGGTGAGCTGCAGCAGGTGCTGGGCTGTGCTTGACTGTGGTCACGTAGGGGCAGGCAGAGGAGCCATTTCGGGGGGCTGCTGAGGGTCTGGAGAGAGGCTCACAGTGGTGAGCAAAGACCTTCTGGGATGGGAGGGGATCAGTTGGCAAAGACAGAGGCAGATACTCCCCACTCCTTTGTGCCTTCCCAGTCCTCTCTCACCCCTTCCTGCCCTCTCCCCACACCCTATCGTGGTGGCAGCTGTGCCTCACTTATCACATGGTCCATAGCTCTGTTTTTTCCCCTTTTATCAGTTACTGCCTAGAACAACCCAATTGTGGTGGTCTGGGTTATCTCCCACTCTTCACAGTAGGGCCAGAGTGGGCTCAGACACCAAACGACACAGAATGGTTATGGCAATGAATAAGATTCCTTCTCTGTGTCAGCAAGGATGCTGATGTAGTAATAATCTCCATTTATTAAGCCATGCTGTCTACAGGGCACATAGCACATGTTTTTCCATTCAAACCTCAAAACAGAGCTATGAGATGCGCACCATTATGATGATTATCTGTTTTACTGTTTTTTGTTTTGTTTTGTTTTTGTTGTTTTTTTTGAGACTGAGTCTTACTCTATCATCCAGCCTGCACTGCAGTCGCCCAATCTCGGCTCACTGCAACCTCCACCTCCTTGGTTCAAGTGATTCTTCTGCGTCAGCCTCCCAAGTAGCTGGGACTACAGGCGTGCCCCACCATGCCTGGCTAATTTTTGTTGGCCAGGCTGGTCTTGAACTCCTGACTTCAAGTGATCTGCCTGCCTCGGCCTCCTAAAGAGCTGCGATTACAAGCGTGACCCACCTTGCCCGGTCTGTTTTACTGTTGAAGTAACTGGAGCACCCAGAGGGAAATCAAGTGTCCCTAGAGAATACAAGCACCATTTGGACAGCCCTGTCTGACTCCAAAGCCACTGCACAACATTGCCTGGAGCTGAGAGATGCACATTCTCCCTTCTTGGCCACTGGTGACTGTGACCTTGGGCAAACTACCTCTGCTTTTTGGGCCTTAGTACATTCATTCATAGAGAAGCTGGCTAATTTCTCTTCTCAGCCTGGAGACTTGAGAGTGAAACGGGCACTGTATCACTTACTCTGGGATGACAGGTGTATACGAGGATGTAGCTGGGCAAGCCACGCCTACTGGCTCGCACACTCATCAGTTAGATCCTCGGTCCTGGTGCTGCTCGTCCATCATCCATACAAGGCTGGCTCTCCCAGTTTTCCCTGGACTTTTGCCTGAACAGTTTGCATTTCTACTCGTGGTGCAGGAGCTTGCTGTTCTGATTTCATGTCACAAGCCTGCTTTCAGCCACTTAGAAGAGCCCTGTTATCCCTGACTGCCGCTACAGCAGTCCCAACCTGTCTTGTTTTCACTTGATGGGCTCCTGCAATTATTGACACCACACTCTCTACTCCTACGGGCTGCCCTGCCACCTACACTGACATCCTGGCCAGGTTCCTGGAGATGGCCTGGCATCTTGGACCTGTTCCCCACGGGGTGCCTGGAGCCTCTGATGGTCTACCCAGGGTGGCAATGAGGGAAAGGCTGTGACTTGATCATCTCCAGGGGTTCTTCGGTGAACAGCCCAAGGTTGCTTAACAGCTGGTGTGTATGAATACCTGGAATGTGCCAGTTCACCTTCTAATCTGGCAAGGAGAATGTGTCTCCTCCTTATGCATATGAACAAACTGAGGTTCAGTGAGATCCAGAAAGCTGCCACGGTTACTGATGGAGAGAGCAGAGAAGCTGGTGTTTGCAGTCCCATCTCTCAGCCTTCACACCCCTACTCCTGTCCAGCCAGTGTTTCTCAAACCCTCCTGATCAGCAATGCAAGATGATTTCATGTTATAGATAAGAATAAAAAAATTGTTTTCTGTTTAACTCAAATTACAAAAAGGCAACAATTGGTATGTGCGACCTGTGGTTTTGCAGATGATACTGCTTACGATCTTGGTACTTAACAAAAGGTCAACTTTTCAAAAATACTATTAGTGACATGTGGACCTAGTCCTCCTGAACAGGACTACATTGGGGCACCGGTAATTGTTTCTATTTGCGGTACTCTCCCTGTGTCCCTCTGGCCACCCCACTCGACGCAGTGTCTGAGCCTGTCACTTGAGTAGTACCTCTGTGTCATGTCTGCTGATTCTCCCCAAATCCTGAAGATTCATGATGAAGTGACTCGCCGGCTTGGTCTGAAGCTAGATTGAAAACAATAAGGATCCCAGAACGATACCACTTTACAATCCTATAATTTGCCTCAAATTGCCTGCAGTTACTATCTCAGCCCTGCCTGTTATGTTCATTGAGCACCCAAAGTTTTTCAGTCAATTCCTGAGTTAATTATTCTCTGCCATTCAATTATGAAATAGTAAATATTTCCACTATGCAATCAATTGGTGACTTATTCATGTATTCATTTCATTCATTTAGTCTCAATAAATTGAAGATAAGGGCTGAGCACAGTGGCTCACACATGTAATCCCAGCACTTTGCGAGCCCCACCTGGGCAGATCACCTGAGGTCAGGAGTTCAAGACCAGCCTAACCAACATACCGAAACCCCATCACTACTAAAAATAGAAAAATTAGCTGGGTGTGGTGGCATGCGCCTGTAATCCCAGCTACTCAGGAGGCTGACGCAGGACAATCATTTGAATCTCGGAGGCGGAGGTTGCAGTGAGCCGAGATTGCACCACTGCACTCCAGCCTGCGTGACAAACTGACACTCCATCTCCCAAATAAATAAATAAATAAATAAAACATAATATTACCTACCCCATGACTTTATTATCACAATTAAATAAGAGAACATATTAAAAGGTTTCATTCAGTGCCAGGCATATAATATGTACTCAGGGAATACTAGTTTTTTTTAAATAAAATTTTAAAATGGGATTAGAAGGTCAAAGCATATACGCATAAAGGTATAAAAAATATTGAAGATCAGTCAGTTACTAAAATTTAACATTACGTTTAGCTCTGAGCTTCCTAATTAGCACAACATGCTAACTAGGTTATATTTCTATCTAAACTAAAGATTGGCAAACTTTTTATATCAAGGGTTAGGTGACAAATGTTTTCAGCTTTCCAGGCCACACACCTCTGTACTGCTTGTCAGTTCTGCCTTTGTATCTGGAAAGTAGCCATACATAATATGTAAATGAGTGGGTGTCGCTGTGTGCCAATAAAACTTTATTTACAAGAACTGGCAATAGGCCTTTAGGCTGTACTTTCTCCTTGGCCTAAATAAAGCAAACATGTTTGTCTTTCAAAGGCAGAAACTCCTCCTGGATCATAAACATTGAAAAAAAAATTGTTACAAGATGCAATATTTCTGTGAGACTTGTTAAGCAGTATATGCGCAGTGCTTTCATTAGGATTTTACAGAAAACTTAGAAGATGGCCTTCACATGGCTAGTTTCCTTACTGTTCATTCACCAGACATTTACTGAGGGCTTACTATGTCCTAGGCTCTGATATCCATACATGGTAAAACGTAAAGGCATGTGCATTTTGGCAGGGGGTGCTGCATTGACAAGGAGTGGTCTCGGTGACAGTTTTGGGAAGTCAGTTTAGAACAGTATTGGACACACTGTTCCATCCCTGAATTACACACAGGCCTCAATCCTAACTTGAGTGGGCTTTTGGTCCAGCAGGCCTGGGCTCCAGGGGCAGTCACTCAGCGTCCTGCCTCAAGAGTGGTTGTGTCATGAAATCTTGGCCCTCTTTGACTGATAGCTACAATTATTTGAAGAGTGTGGTTTTTAGAACAAAACTAAATCTGTTTTGAAGCTCTGCTGTTTTATACCTGCTGTGTGATCTTGCTCAAGTTTTTATTTTTATTTTTTTCTGTATAAGGGATTTTATTTTATTTTTATTTATTATCTATGTATTTATTTTATTTTAAGTTCTGGGGTACATGTGCAGGATGTGCAGGTTTGTTACATGGTAGACGTGTGCCATGTGATTTGCTGCATCTATCACCCCATCACCTAGATATTAAGCCCAGCATGCATTAGCTATTTTTCCTGATGCCTTTCCTCCCCCCCCCCGCCCCCGACCCACAGGCCCCAATGTGCTCAAGTGTTTTAATCTCTCTGAGCCTCACTTTCTTCATCTGCAAACCATAACACCTCTGAATCTATTTGTTACTCTAATGCTAGCTATCTAGTGTTTGCTCTCTAAATGTTAGTTCCTCCACCTGGGGGCTGGGCGGGCGGTGGCTGACCTCACCCCATCAAGCTGTCTCCTGGCTTTCCCAGCTACAGCCTGTCCGTATGAACATTCCAGCCCCCTCCTCCTGCGGCAGTATTCAGTGTAACAAGCCTTGAGAAAACACTGGCCTGTGGAATTCCAAAGTTAATGAAGGGAACAGATTCCAAGAGGGTCTCTGTTTGACCTTCCACTCTTTCCCCAACCCCGTTACCCCTGAGCGAGTTTGGGGGCAAGCATAGGTTTGTAGGCACTGCAAAGAAGAACTCTCACGCTGTGGTGCAGGACCGTCGCCTTGGCCTCTGGATATCTGGGCCAGGTGGGTCCATTTGGGCCTCTTCCCTACAGCGCCTGGTCAGACTGCAAGAGACATAGGAAGCAGCCAGGGCAGGCTATCTTAAGAGGAGGGAGCATATTTGATAAAGTTAGAAAATGATTCTCAGCTGTCCATAGGAAGAGCAGAGTAAGGGGCTATGTGAGAAGTTTGGAAGATGGCCCAGTTCCAAAAATGAAGAAAGAAAGTAAGAAAGAAAGAGAGAAAGAGAGAAAGAAAGCAACCAAGGAACGAAGGAAGGAAAGAAAGAGGAAAGAAAGAAAGAGGAAAGAAAGAAGGAAAGAAAGAACGAAGGAAAGAAAGAAAGAAGAGAGGGAGAGGAAGGAAGGAAGAAAGGAAAGAAAGAAAGAAAGACAGACAAAGAAAGAAAGACAGGAAGGAAGGAAGAAAGGAAAGAAAGAAAGAAAAAGGAAGGAAGGAAAGAAGGAAGGAGGGGAAGAAGCAAGAAACAAGGAAAGAAACATTCATTATTCTGTCCTCTGAACCTGAGTGAAGAAAAATACCCTGTCCTTTGTACCTGCGTGAAGAGAGAAAAGAAAAGAAAAGAAAAGAAAGAAAGAAAGAAAGAAAAGAAAGACAGGAAGGAAGAAAGGAAAGAAAGAAAGAAAGAAAGAAAGAAAAAAAGACAGACAGGAAGGAAGAAAGGAAAGAAAGAAAGAAAAGCGAAGGAAGGAAGGAAAGAAGGAAGGAAGGAAGAAAGAACGAAAGAAAGAACATTCATTATTCTCTCCTCTGAACCTCAGTGAACAAATATACTCTGTCCTTTGTACCTGCGTGAAGAAAGAAAAGAAAAGAAAGAAAAGGGAAGGAAGGAAGGAAAGAAGGAAGGAAGGAAGAAAGAAGGAAAGAAAGAAGATTCATTATTCTGTCCTCTGAACCTGAGTGAACAAATATACTCTGTCCTTTGTACCTGCGTGAAGAAAGAAGAGAAAAGAAAGAAAAGAAAGAAAGAAAGAAAGAAACGAAGGAAGGAAGAAAGAAAGAGTGTAAAGAAATAAAAGGCTCTAAAGAAATAAAATAATGTAAAGAAAGAAAATAATGTAAAGAAAGAAAAGAAAGGAAAGAAAGATTCATTACTATCCTTTGGACCTGAGTGGTGTTTTCAGTTAAAATGAGTGGAGTAGAACCCAGAGATCAGGCTTTTGACCACGGTAAACCCTCAAGATACATTCTGTTTCTGCCTCAGCGAACCTTCACGGAAAAGGCTTTGGAGACCAAGCTACGCAGGGAAGCGCCTTTGCTTATCATGCTGGAGACCAGACTGAGGCAGTGAAGTCACCATAATTGATGGGCCACACTAGACTGGAGCCAACCATGGCCCATTGCTGAGACTCTGGGCCTCAGGGTGGCCTTGGCTGGAACCTGTATTCCAGTGGCCCTGGTGGCTCTCTTCCCTCTCACCTTCCCAGGAGGCAGATTATTTCCCTGTGGTGGGGGTGAGGCGGTGGCGTGGGGGCTTCTTCCCTCTCTCTCTGTCTTGTAGCCTTGTTAAAATAGTGGCCACACGCTGATAGCTGGATTTCCAGTGCAGTTGCTGGGGATGGGGGTCTTTCCCTCTCATCTGTCTGTCACCCTTTATCACTCCACAAGGGGTGCGCGTACTGCACACAAACACTGTGTCCCACCTGATTACTGGGAAGTGCAATGGACACCCCCACCCCCCGTTCACTTATCTGGCTCCAACCGAAGAACAGCTGTTGGTGGTCAGGTCTCTGAGTCACTCAGTAGCTTGGGACTGGGTTCAGTGGGAGATGATGGCATAAACAAATAAACACTGGCTGGCCCCCAGCTCTCAGCTTTCTGCTCACTGGGGGGCCCCAGAAGCTTCCTGTTGCGTCTGCAGGGAAAATAAGCATACCCATAATGAAAATAGTTTTCCTGATGGAGAAATGCTCTGGGGAGGTTGTTGAGGCATGTTACAAAATCCCTGAGGCTTTCTGGCTCTGTGAGCTAAGGGAGGACACTTGGCCTCTCTGGGCTTTCGCTTGCTCCTTTGGCAAGCCTGTTATTGTGAAAGTGAGATGATCTGGGAGGTAAAACTGGCCAGTTGTCCATCTCCCCTCTCTGAACATCATGCATAGTAACCCCTGAATCTCATTTAAATTTGGAAGTCAGACTGACTTTGTGACTGTCCTAGTTTCCGGCTGTTGAGTCAGCTCAGGCAGTTCTTGGGACTTCTGTGAGTCTCTGGCTCCCCGTCTCTCAATGGGGTGACAGTCCTCGTCTTGTGCCCCTCACGCGCTTGTTGAGATCACAGATGAGTCACCTCTGGGAAACTGCCTGAGAGCTGGATGACACCACTCTGTGGGATTCCATTTCATCCACAGAGACATCTGGAAAAGGAGGCAGAGCAGAGCCTGACTTTTGATTATTTGGGGAGGGAGCCTGGAGCTCGTGGAAGTGAGGGCATAGAGCACATTCCTTTCAGGCCAGGCAGTGCTTGGCTGCTGAGGCACCGGTGGAGACCTCATGATCTGGTGGTCCGCCTCCCTCTTGTGCTGTGTGTGCCTGGAGCTCTCTGGCTTCCTTGGCTTTCCACTGTCTTTCCCAAAGCCTCCATGTATTCTAGAATCTGCTATGCAGTTTCACGGGGATCTCTGTATAGTGTGAATATCTAGCTCTGAAACACAAAAGAGAAAGCTACAAAGCCCAACGTAACAAAAGCCGTATTCCCACCCAAGGATTAGCACATGCTCATGAGGTGGCATGCTTTGCTTTGGATCATTGTCTTTATTTTATTTTATTTTGTTTATTTATTTATTTATTATTTATTTTTTGAGATGCAGTCTCGCTCTGTTCCCCAGGCTGGAATGCAGTGGTGCAATCTCAGCTCACTCCACCCTCTGCCTCCCAGGTTCAAGCCATTCTCCTGCCTCAGCCTCCTGAGTAGCTGCGACTGCAGCCGCGTACCACCACACCTGGCTAATTTTTTATATATTTAGTAGAGATGGGGTTTCACTGTGTTAGCCACGATGGTCTTGATCTTCTGACCTCATGATCCCCCCACCTCGGCCTCCCAAAGTGCTGCCATTACACCCATGAGCCACCACACCCAGCCTGGATCATTGTCTTTAAAGAAATTTAAAAAAAAAAATAGATAAATGCGAACTCTATGACCCTTGTCTCCCATTCCCCATCCTTCTCTTCATACAAGTACCTCTCCTGAACTTCCGGTATAACACGTCATGCTCTTACAATTTCATTACAAATCTATTTGAAGATCACTGGTAGCACCATTTTCTGTGTTTTTAAATTCTTAGGTAGCTGACATAACGTATAAGATGTCTGCACTTTCCTCTTTTCTCCCGGCGCTATGCTGGCCAGATGATGCTACTATGCTTGTTCATTCATTCCCTGGGCCACAGAGTCTTGGGTTGTTTCCAGAATTTTGCTTTTGTAAACAATCCTGTCATGAGCATCCTAGCACAGGGCTGCAGGTGCATGTCTGGGTGTGTCCCAGCCACTACAGGGCACACAGCATGCACATTTGCAGCCTGACTGGAGGTTGCCACATCACTCTCCAGTTGGCACTATTTCCTAGGTTCCTTCCCTCACAGCCTGCCAACTTCTGCAAGCCAGCAGTGGGTGGTCTTCACCACTATATACCTCTGCCAGTCAGCATCCCCCACACCATGTACCAGCTCATGACACGCCTGAATGGGGTGAATTCTCGAAGCGGACAAGGCAAGTGCCAGCCCAGCTCCAGACTCTGGGTGTGGAACGACCAACATAATGCGCCCCCCTTGCAGAACCAGCAGAAAGAACAAAGAAATAGGCGCCTGGAGTGGGGGTGTGAATGAAGACATTGCTGTTGAGAAGATACTTGTGAACAACCCAACACCGTTGTCTGCCCCTGGCTCCATATCATCAGGCTGCACATCGAGGTCCCAGGCACCATTGCTGTGGGCTTTTGGGCAGTTGGATGCACAGTGGAGACCTGAGGAGGAAGTTCCCCTTGCTGCACACGCCTGCTGGAGGGGCTGGCTGGAGTCTGGCTCTGGCCCTCACTCACTGAGGGTTATCCAAGTGACCCATTGCAGGAAGAGGGGTGGGGGACCCAGAGTTACTGTAACCACTTTATGAGTCTGTCTCAGCCACCATCTGCGCCTTCTACCAAACCCCACACCACAGGCACATTTTACCAAACCCAAGATTGACATGCCCTCGCTGGCCCAGAAGGACACTTCAGGGCAGCAGGGCTGTAAAGGTCAGGAGGGGGAAACTTCTGGAAGCAACTTCAATCTTGTGGGAAAAAGCTGACATAAATGAACAAGGAATGATTTTTTTCTTTTCTTTTTTTTATTTTTCTTTTTAGAGAGACAGTCTTGATATGTTGCCTAGGCTGGTCTCAAACTTTTGAACTTGAGTGATCCTCCCACCTTGGCCTCCCAAAGTGCTGGAATTATAGGCATGAACCACCATTGTACAGCCACAAGGGAAGATTAAACATAGACAGTTTGAGAAGAGTTTTTTTTTTTTTAAATTTCTAATTTTATATTTAATAGAGATGCAGTCTCACTATGTTGCTCAGGCTAGTCTTAAAGTCCTGACCTCAACCGATCCTCCTGCCTTGTTCTCCCAAAGTGCTGGGATTACAGGCTTGACCCACTGCACCTGGCCAAGGGTACTTTTTTTTTTTTTAAGAAAAATATCGTTAGAAATAGAAAATTTGCATTTGGTAATGGATACTGGATAGTATGAAATAACCTTTTTACTTCTTCAACACTTCCCATGATAATAACACTAATACAAGATCTTTGGTGAAAACTTAGAATGCGTACAAATGTGTTGGTGGTTGAAAGAGAGCCCCATAACCCTCCACTGAGGAGTAACCTCTGTTTGACCTTAGAAATAATACCTGTGAACAGAATGGCCAACTTGTCCTGGTTTGCCAGAGACTTTCCTGGTTTTGGCACGGAAAGTCCAACACTCTGGGAACCTCCTCAGTCCTGTGCAAACTGGGATGGTCGTTCACCCTACCTGTCAATTGAATGATACCACTGAGCATCAAGCACTTTGACAGTTCACAAGTCATTTCTAGTGCTGTCATTGTGTATACTTGGTTCCCCCTGTGTCCAAGGCATTGTGCGAGGCTGCATGTTCTGGAGCTACACCAGAGCTCCAGAGCTCAAGTTCTATTTTCTTTTTTTTTTTTTTTCACTTTTTATTTTAGAATCAAGAGATGCATATGCAGGTTTGTTACAGAGGTATATGGGATGCGGTTGAAGTTTGGAGTATGATTGAACTCATCACGCAGGTACTGAGCATAGTATCCAGTAGTTTTTCAATCCTTGTCCCCCTCTTTTCCTCCCCTTTCTAGTAGCCCTCAGCATCTATTGTTCCCATCTTTATGCCCATGTGTACCCAATGTTTAGTTCCCACTTATAAGTGAGAACATGCGGTATTTTGTTTTCTGTTTCAGCATTAGTTTGCTTATGATAATGGCCTCCAGCTGCATCCATGTTGCTGCACACAGCGTGATTCCATTCTTTTATATGGTTGCATAGTATTTCTTGGTGTATATCTCCCACATTTTCTTTATCCAGTCCACCACTGACGGGCATTTATGTTAATTCCATGTCTTTGCTATTGTGAATAGTGCTGCCATCAACACATGCGTGCGTGTGTACTTTTCGTAGAACAATTTATTTTCCTTTGAGTATACACCCAGGTATGAGATTGGTCGGTTAAATGGTAGTTCAACTTGGAGTTTTCTGAGAAATCTCTAAACTGCTCCTCACAGTGCCTCGACTAATTTACATTCCCACCAACACTGTGTCAGTGTCTCCTTTTCTACACACGCCCACCAACATCTGTTATTTTTTGACTTTTTAATGAAAACCATTCTGATTGGCATGAAATGTATCTCATTGTGGTTTTGATTTGAATTTTTCCAATGACTAGTGATGTTGTGCATTTTTTCATGTTTGGTGGCTGCATGAATGTCTTCTTTTGAGCAGTGTCCGTCCTTGTGCTTTGCCCACTTTTTAATGGGATTATTTGCTTCTTTGCTTTTTGATTTAAGTTCCTTATCGATTCTGGATATTGGAACTTTGTCAAATGCATACTTTGTGAATATTTTCTCCCATTCTGTAGCTTGTCTGTGTACTCCCTTGATAGTTTCTTTTGCTCTGCAGAAACTCTTTAGTTTAATTAGGCCCCAATTGTCAATTTTTGTTTTTGTTGCAGTTGTTTTTGAGGACTTAGCCATAAATTCCTGTCAAGGCCTATATTGACACGGGTATTTCCTCGGTTTTCTTCTAGGATTTTTATAGTTTGAAGTCTTAAGTCTTTAAGCCATGTTGAGTTATTTTTTGTGTGGTGATAAATAGGGATTCTGTTTCATTTTCTTCTGCATATGGATAGCCATTTATCCCAGCACCATTTATTGAATAGGAAGTCTTTTCCCCATTGCCTCTTTTTGTCAAGTTTGTTGAAGATCAGATGGTTGTAGATAAGTGGCTTTATTTCTCGATTCTCTATTCTGTTCCGTTGCTCTGTGTATTTGTTTTTGCACCAGTACCATGCTGTTTGGGTTACTGTAGCCTTGTAGTATAATTTCAAGTCAGGTAATGTGAGGTCTCTAGCTTTGTTCTTATTTCTTAGAATTGCTTTGGTCATTCAGCCTCTTTTTTGGTTCCATGTGAATTTTAGAATAGTTTTTTCTACTTCTGTGAAAAATGATGTTGATAGTTTGAAAGAAATAACATTGAATCTATAAATTGCTTTGGACAGTATGGCCATTTTAATGATTTTGATTCTTCCAATCAATGAGCATGAAATGTTTTTCCATTTATTTGTGTCATGTCTGATTTCTTTCAACAATGTTTTGTAGTCCTTGTAGAGATCTTTCACCTCCTTGGTTAGAAAGTATTACTAGATATTTTATTTATGTGTCTATGAAGCCCTGTTTTCTATCCTTAAGGAGCTTACAACTTCTCTTTGGTATGCAGTAGCCGCATTTCACTTGTGAGAGTGGGGGTCTTACTGTAGCCTGGGCAATACCCTCTTTTATTATTGGGTACTAAGGATTTAAGGATATTTTTGTTCTGGTGGGTTATCCAGTTTTGCAGGTTGGTACCAGGAGAGAGGATGCATGTTGGTACCAATGCTGAATTTGACTGCCCCTGGCCCTGCTGTGCAGCACTTTCAGACCCCTAAATGATCTCACCCATTCTGGCGCCAGCTCAGTGTTTTACAGTCATGAACATGATGTTGATGATCATGATGATGATGTCAACATCCATCATTCTGAGGTGTGTGTCTATCTCTGGCCTCGTTATACCTGCAGAACATTCATGTGGTAGCCAATACCTGGGAAAATAATCCCACTTCCCAGGCAGCAAACCGTGGCCCTCCGTTAGGCGGATGGCATCTCACACTCATCAAGTCTTGAGTGTATGGGTCCCTGGCCAGCTTTGGCAACTGTGAGGCAGGCATTATCCTTCCATTTTACCACTCACAGACTGAGGCCGGTGATGGGGAGCACCTGCGCCTCTTGGCTTGTCTGTGGTAGCCCACGCTGGCTACATAATATGTGGGGCTCAGTGCAAAATCAAATATGGGCTCTCTTGTGTAAAAATTAGGAAGAATTTCTAGATGCTGACACCACAGCTTTAAACCAAGCTCGGGCCCCTCTGAGCCAGGAGCCCTGTGTGCCTGCACAGGCTGTATGTCCAAGGAGCTGGTCCTAGGGCAGGACTAAGGTTCAGGCTTCGTATTGACTTCCATGACCAAGCATCCTGGGTCCAGGCTGTGTTTTGTGTGTCTCCACAGCTCTCCTCTATCTGCTCATAAGTCCCTCTCGTGCTCAAAGGTACCTCGCTTCCTTGCAGAAAAGTTTCTCTCTCCCCTGCCCTTCCCCAGCCTCAAAATACACAAATGCTCAGATGAATACTTAACAATCCAACTGCACCAGCTTCTGTCTGTGACTTCATCACTTAATGTGATTTTGGGGGATGCAACATTGGGGGTGATGCTTTAGCATGCCTTCTCTCTCCCACTCAGGAACATGGGCAAATGCCATGGGCTCGCAGCTCTCACCTGCTCTTTTCTGCTGAGCTTCACTATCTCTTCTGGGCACAGATTGGTTACAGGGATATAGACCACCTGTGTCGTGCCCTGGGGGTTATGTCCACGGGGAGCCTCACATGAAGAAGAGAATTTCCTTTGGGATGTGTATTTCTTGTGGTCTTAGCATGCTGGCAATTCTTATTTTTCGCATCATTTAATCCTTACAACAACTTTGTAAGGTTTTCACATCCATTCGTCATTTCTCAGTTGAGCACCTCAACTCAGGTGAATGTGTTTGTATGAATGTTTGTTGAGCACCTACTATGTGCAGGGCAGTGTAGTAAAAAATTGAGGACCTGTGCCTTTTTTTTTGAGTATATATAATTCTGTTCTTCTGTCATTTTACATGACTTTCACCTCATTTCATTGCTGTAGCAACACTGTGAGGTTGTTGCTGTCACCCCCATTTCTCAGGCGAGGAAATAGAGGTTGAGTCAATCTCCCATCTTGGATTTACCTGACATCACAGTCTGAGTCTTTTGTGGCATGTGCAAGAGTGCACTGGCTTTCGGGGCCTGAGCTGGCTGGCCTGGATTGAATCCTGGCTTTGCCATTTCCAGCTGTGGTCTGAGGCAAGTTATTTAACTTCTCTTGACCTCGGTTTCCCCATCTCTAAAATGGGGCTATACTAGTTGCTCTGTGTAGGAAGGGTCTGAGGTTTCAGTAAGATACATTTTGCACAAACCCCACACACACCAAGTATCCATCAACCCTGGTTATCCTTATAACCTCACAGCGGTTTGGAGAGGGTTACGAACTTGCAGATGGTCACATAATCGGTGTATGGCAGATCTTGGGCAGAGCTGGACTGGTCTTCCTAATCAGAGCTCCTTTCCCCACTCTGCTTTCATGGACAGACCCTAATGACCACCTGGGTTATGTTTTTGTCCCTGTCAATTCCTTTGTCCTTGCTGATAACCTAAGGGAACCTTGAGAGCCAGAACGAGACAGGAAGAAAATGCCTGGCTGCTCCTTGCGGGGTTAATTAAACCATTCCTGGGGTTTCATTTGCTCTCTAGTTAGCACCAAAATAAATCCTCCAAATGCCTTTGAGCCTTCCAGTTCACATTGCATTTTGAATTCTCACAGCACCAGCATTTTACATCTTCCTGAGCATGATAAATGTTTACATACCACCGAAGATAATGGTAAAAGGAGAAACTGGGGGTAGTTCAGGCTGTGGCTGAGCAGATTGTAACTCTTTGGTGTGACCAATCGCTGACAAGTTGCTTAAAGGACACATCTGATGTCCCCTGCTCCTAGCCCTTCAGAGGGGGATGGCGGGTCGACTCTGTTTTGCCATCCGGAGAATCCATTGCCTTCCCGATGCTTCTGGGGTCTCATGCTTGAGTCTTGTTTCCATGCGTTCTGTCAGATGTTAAGGTCTTGTGCATAATGGTTGAGGTGTCAATGTCCAGGCGTTAATGTCACCATTCTTATCTAATTGTTACCCTTTATTGAGTGCCTACTATGTGCCAGGATTTAAATATTTCTCTCAGCAACCCAAACATGTAGATGTCATATCACCTTCATTTTACAGATGTGAAAACAGGCTCGGACACGCTGAGACACCCACCCATTAAGGACTCAGCTGGGATTCCCAGCCTTCCCTGGCACTCTCTCTTTTTTTTTTTTTTTTTTCTGTTTTGAGACACAGTCTTGCTCTGTCACCCACGCTGGAGTGCAGTGGCACAATATCAGCTCACTTCAACCTCCCTCTCCCGGCCTCAACCAATTCTCCTGTCTCAGCCTCCCGAGTAGCTGGATTTGCAGGCATGTGCCACCGCACCCGGCTAATTTTTATTTTTAATTTTTTTTGGTAGAGACGGGGTTTCACCATGTTGGCCACGCTACTCTTGAACTCCTCACCTCAGGTAATCTGCCAGCCTCGGCCTCCCAAAGTGCTGGGATTACACCTCTGACCCACCATCCCCGCCCTTCCCTGCCACTCTTCAGCATGTTTCCAGACCGCCTGCTTCCTACCCCAGACATGTCAAAATGCGGTGCTGTAAATGACAGGGCTCTGGTCCCAGATGGACACCCCCGGCCCTTTGAAGACACTCTGGCCTTCAGGAGTCTGGATCTTTATCCCTCATCGAACTGACACCGGCCTCCTATGTTTACAGTGCCTGTTCTCCTGCAGCCTCTCCGGAAGTCATCAGCCGTGCTGGCCAGCACTCCGGAGGATGACAGGAAATTCTGCTGCAGCTCTGTGGGCTGGCTGGGGTGCATGCTGGACAGGGACCCCCCCCACAGGGCTGGTAGGGACGAAAACACCACTGAAATAGTTCAGACCGTATTGTCACTGAATTCCTCCATTAGTATGCAGTGCTGCCAATGATCAGATTTGCCTCACGAAGCCCAGATGGCACAAAGATTCTGTTAAATCTTTATATTTTTCCACCAAATCCTCACCGTTTCAGACCCTGTTTTCTAAGCTATCACCCTAATAATTGTGGATTTTGGATTTCCAACCCACGTTTTATAGTGGTTGTAAGGAGGGGATGGTTGGGTTGGGGATTGGGATGGGAGGGGGGTAGCTGAAGAAATAAGAAAGTGCTGCAGAAAGGAGCACATTCCACACCCACCTTCTTCCTGATTGTGTTTCCCTCCAAGCAGCGAACAAGACCCTGATTCAACTGGCTCAGTGGCCTCCCTCCCTGGAGTTGGGTTCCTATGCCTTCCACTCACTAAGGAGGAAATTCCATTTCAGTTAATCTGTGGCCGCGCATCACCCATGCCATTCTCTATCTTAATTTTATGGCTGCCTCATCTTTTTGGAATTCGCCTTCTTTTTGTGTGTTGGGTGATAAGTCAAGGACACATATGGCACAGCTCCACAAAATACAACCACATTTTAGTATTCCGTACACAGTCCTTTCTGGGCATCCCACCCTTTGTATTTTCACCTTGGTCGGCCGTGAGCACCGTGGATCTTCATTATCTGTGCATGCATGTGCATCCCTTCATCCCTTCCTCTTCACTTTCTTTTCTTTTTTTTTCTTTTTTCTTTCTTTCTTTTTTTTTTTGAGATGGAATCTTCCTCTGTCACCCAGGCTGGAGTACAGTGGCCTGATATTGACTCGCTGCAACCTCCGCCTCCTGGGTTCAAGCGATTCTCCTCCCTCAGCCTCCTGAGTAGCTGCGATTACAGGGTTGTGCCACCACGCCCGCCTAATTTTTGTATTTTTAGTAAAGACGCGGTTTCACCATATTGACCAGGCTGGTCTCAAACTCCTGACCTTGTGATCCGCCCACCTCAGCCTCCCAAAGTGTTGGGATTACAGGCGTGAGCCACCACATCCAGCCTCCTGTTCAGTTTCTTAACCCTTGATGGGACTCCCGGCTAAACACCCCCATTGTCTGCCACCTTGAGATTACATGCAGTAGCACTGCTGGTTTCATGGTGGACTTTGAGTCGGATGGAGGAACTCCTTGGAGTGCGGGAGGAAGGGCTGCGGAAGGTGTCTGAACTATCGTAGCAGTACGGTCCCTGCCACAGGGAGGTGAGGCAGCCATCATCACCACTCCTAAGAGGTACGGTCACCCTCCGCCTCTGTCTCCCTCTCCAGTCCCCATCCAATTTCACCTTTGAACCCAGCTGCCGGGTCTTCAAAGCCTGTTCTGACTTACCCAGCACAGTTGCTTGCTCTCTCCTCTTAGCTTATAGACGCTGCCCGTTTTTTCCCCACGTGGCCCCTGCCATTTAGGTCCATGTCTCTCGTGATCCTGTGTGTATTTCCAGTGGAAGGACAAGGTTTGGCCCACTGTATATTTGAAGGCCCTCAATATGGCGTTAGTTCGTATTTACTGATGGATGAAGAACTCTGAGGAGATCTGGTTGAAAGAGACTTTTAAAAATTAAACGGAAATGGGTCACGCAGGCCGCGTTTTTGTCCTTGCCTATTGGCTACTTTTCCTATTCAGATCATCTGTGAATGTAAGTGACTGTCTGCTGTGTTCGCAGTGTGGTTACTGGGAAAACAGAGCTCTCTCTCCCCAAATCAGGTGAAACTACAGGAAAACAGTAGGCAAGAGTCTTCAAAGTGATGCATCTCGAGAGAGAGAGGGCCTGGGTCTGAATCATGGCTTTGTGCCTTACCAGCCTGTGATTCTAGTCACTTTACCTTCTGAGCCTTGTTTTTCCCAGCTGCAAAATGAGTGTGATAATAGCGCTCGCTTCAGGGGATTGTTTCAAGGATCAGTTCAAATAGTGCACACCGAATGTTTGGCATATGTGCGGAGCTCTTTGGGCGTGACTCATGGGCAACTGTTTTTCATTTAAGAACTGAGTGGATTGGACCTTTAAGAACTCCTTTGGTCCCACTGTCATGGGAGGTTAGTGCTGTCTGGAGCAGGCATGGGGATGTCGTGGTACAGGGTAGGGTGTAGGGGTCCCCAGAATTGGGGGCCTCCCTCTTCGAAAGGGACAGTGGGCAGAGTCCATGCAGGCGCTCTGGGGCTGACAGGGACCTGGGACTTCTTTCTGAGAGGCAGTGACCAGCCAACTGGAGTGGAGGGTTGTGGGGAAAATGTTTGGCCAAAGGATTTAGGAACCAGAGAGAAGCAGGCACATGATGCTCCTTTTCTTGGTGGGGTGTTCATCAGGCCTGTAGCTGCCACAGTCATCACTGTGGCTGAGATTCATACCTGTAGCACCAGAGTGGGAGGCAATTTTTCCAACATGGGGCAGAGGCTGGGTGTGTGGGGATTGGTTGCAAGGTGCTGGGAGTGGGGTGCAGGGAAGCGCCTCTGCACACCACGTCCGTCCTCATCCTGCTATGAGGTCAGCTCTGTACATGTGCTGCAAGAGCAATTAGCGGGGTGCCTAAGCAGTGTCCATCATGGACGTGGGTCTCTGCTGGCCACGCAAGGGGAACATGGGACTGGTGGGAAGATTGGGGAGATGGAAGCGGGGGCAGTTGTGTGCGAAAGGTACAGGGTCGTGGAAACATGCACAAGAAAGTGACATTTTAGAAGGTGGTTTTTGTTCCATAATAAATTTATTAGCTTTGGAATCTGACTCTATTGCCTTGGCTTCTCCAAACTTTGGTGTCCTCATCTGCAAACTGGGGATCACAATCTCAGTTTTGCAGGGAATGTGAAATCCTGACCTGAAATGATCACATGTGTAGGAAGCTGACAAAGAATGCTAATTTTCTTCCTTCTTTTCTTTATGGCCTTTCCTTGCTAAATCTCTGTGTGATTGATAACTCATGAAGAACCTACCAGTCAAATCAGTTAAATTAAATGACTTCCTAATGATAATAATTAGATTAGTAACTAATAATCATAGCTGACATTTATCTAGTGCTTATTAACTTCTGGGCAGTGCGAATTTGGTCTCATCTGTTAAATAATTTAATTCCTGTAATAATCCTAGGAGGATGGTGCTATAATTAGCCCCATTTTACAAACAAGAAAACTGGAGGATCAGAGAGGCTAAGTATAATGTCTAATCTCACACTGCTGAAAGTGGCTTGCTGGTGTTCCAGCCCCAACAGTCTGGCTCCAGAGTTTGTGCTATTAACCATTATATCAGTCTGCTGTGTGTCTGTGTGTTTGTCTCTCTGTGTGTGTGTGAGAGAGAGACAGAGAGAGATTGTGCATTGTACGGTGAAGAGCAATACAAATCATTATAAGGCATTCCTGTGCTACAGTCTTGGTGGGTCAGGCTTACTTATAGAAGCTCTGAGAAGGATGGGGCTATGGGCTTTAACTCAGTTCTGACAATCTGTCACTCCCAGAACCTCAGGCAGGCTGGACCTATAGACTTCCACCTCCTCTTCCTCCTGCCCTCAACCGTCCAGGGACTCAGAGGAGGTCAGACAGGTGGGACTCCCACAATAGTGACCTCCTCTCCCACTTGCAGCCTATGTCGGGCTCCTCTTATAGAGCCACCCCCTTGCTTATGCTGTAGTGTTCCTTTGTTCTGGCCATAGTTTTCCTGGGCCTGTGTCAGTTCAGTGCGTCCAGATGCAGCTGGGTTGAGACTCAAAGCCCTGAAGATACCGCAAGGGGAGTCCTCCTGTGTCCACTTGCTCTGACCTGCACAGCAGGTCGGAGTGCCCGCCGCTCCCCGGCTGCCAGCTGTTTACCTGGCCGGCCTTGCAAAGGCTCTTCAGCGCCAGGCCCCACCCGGTGAATCACTGAAACTGATCCCCGTGGCCACTGTGAAGTACGGGACTGGAGGTCTCCGGAGGAGATGGCAGCTCTAATAAAAACAGGCTGCCAAACCGCAGAAACTGTATAAGCCTCTGTTTCTCATCCTCGCTACCACCCCTCCGTAGTCCCTGTTTTACAGTTGAGGAAACCGTGGCCCAGGGAAGGTCGGGAACTTGTCCAAAGGCACAGTCATAGAACTAGGGCTTACACCAGCTGTGTCTAATAGCATGCGTGCCCCCTCTGCTCTGCTTTTATTTGCTTCTTGGAGTGCTGTTTAGAGAAATTGATGGTTCTTTTGTTGTGACTAGGGGTCCGCACTATGGGTGACCTCCCTGCTCCCTTTGGCCTCAGGCCCTTATCTTAGGCGATGGCCAAAAGAACAGCTTTACATTCAGTAAACTGTTTTAACTGAACCTCACCACAGGTTTACGGCTGGTGCTCGTTTCATAATGGATAAACAATGGGTGTGGCTCAGTGTGGGGAAGTTGGTGGATGGGGAGAGGGCAGCAGAGTAACCAGCTTTTAGTGGAGACCTGGATTTGAGTGCCCTGAGTTAGGTGAGCCTTTGTACCTCTTTCTTCACTTCTTGGAGCAGAACATTAGTTTCTCCAGATCCCACATGTCATAAAGTTCTGTGATCCTGCAGTTTGAACATCCTGGCATTCAGCTCAGCCCACTCTGCAGAAATCTATACTAAACATGTAGACAGTTTAGGAAGAGGGATTGTTTATTGTGTTGAATGTTATAGAATAATAGCTACTTAAATTTTGGAGCACTTGCCATTCATCTTCCAAGTGATTTCTACGTGTTGACTCATGTAACACAGGCAACCACCCTATAATAAGTACTATGTTTACACACCCACTCTACAGATGAGGAAACTGAGGCTCAGAGGAATTAAGTAATCTGCCAAAGATCCCTTGGCAAGTAAGTGGCTAAGGGGGGATTGGAACCCAGGGAGAGAGCATAATCCTAGGAGGAGATTCTGCCAAGGTACAGCCCTCCACCATGGAAGGGCAGCAGCCTCCTGTGAGCTGACTCACTTGAGTTATTCCACACCATCCCAGTGGAGAAGTTGGATTATCCCTATTGTGATAGAGGAAGAAAGGTGAAGGAATTTGCCAGAAATTATAAATGGTGACATTCGCATTGAACACATGTCCACTGACCCCAAATACTGGGTCATTTTATATCTTTCCCTCCCTTCTTTTTTTTTTTTTTAGACTAGTCTCACTCTGTCACCCAGGCTGGAGTGCCATGGCACGATCTTGCCTCACTGCAACCTCCACCTCCCGGGTTCAAGCAATTCTTCTGCCTCAGCCTTCCAAGTAGCTGGGATTACAGACACCTGCCACCAGGCCACACGAATTTTTTGGATTTTTAGTAGAAATGGGGTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTCACCTCACGTAATCCACCTGCCTTCACCTCCCAAAGTGTTGGGATTACAGCCGTGAGCCACGCCCACCCACCCCCTTCACACCCCACCTTGTTTTTTTCTTTTTAGTAGAGATGGGGTTTTACCGTGTTGGCCAGGCTGGTCTTCAACTCCTGATCTCAAGTGATCCCCTTGCCTCGGCCTCCCAAAGTGCTGGGATTACTCGTGTGAGCCACCACGCTTGGCCTCTTCCCTCCCTTCTTGCTAACTTTGAAGCTCAGCTCCTTGTCCAAGAGCCTTTCTGTCCAGGTGTTTTCATGGTGCCTGTGCCTTCTGCTGGTTTGGAGTGAGCGGTTTCCACAGCATCCTCCCATCAGCCATGCATTCCTCAGGGTCACGCCCAACATGCTCTTCATATCTGCTCCCTGCCACTTGCCCTTCAAACCAGGAATTCACTGCACCTAGCCTGATCCATTGACCTGGGCCCAGTATAGGCCCTCCCATGTTGGGAGGCCATGGGGTGTTAAGGTTAATGCTGCGCCACACATGACTGTGATGAGTCCCTTTCTCTCTCCTGAAGAACGTGTTTCCATCCGCGACAGGGGCAGTTAAGCCTGGCTTCTGTTGGGCGCTGCTGCTTGGGTGGGTCCAGTCTGCCCCATGTGGGGTCTGCATTCTATGCCAAGTGTTGCCACCTTCTGCCAGGTACACCTCTTCAGTATGGAAGCACTTCCCTGTGCTCAGCCTCTCCCCGACTGTGCACATTTCCTTCTCTTCTGCTGGGGAAATGGAAAACAGCTGACCACTGATTCCTTGAAATCACCTACTCAGACACTCCAGGGTCTGTGTGGGATTAAGTCGTCCGCAGTCTTTCCCTCCCTTAATCTCTTCTAACCTTCCTCCAAACTCCCCTTTCCCACCCCATTTTAATCATCCCCTTTGCTCTCGCCTGGACATCTCCACGGCCTCCAGTGCCTCTCTAAGTGAAGCGTTTGGGGCCACACACATGGCTGTCTCTTCTCTCCACGCCCACATGCAGAATCCAGCAGCCCCCTGCCCTCACACCTGCTTTTCAGTAGTGGCTGGGACTGCCAGATGAATAGGCTTGAGGCAGCATACGAGTTTGCTATACACTTGCTCAAAACATTAGTGGACTCAAAACCAAAAAGACAACCCAGTTTCAGAATCGGCAGAAGACTTCAACACACATTTCTCCAGAGAAGTTATATAAATGGCCAATAAACACATGAAAAGATCCTCAGTAGCCATGGTTGTTACCGAGATGCAAATTAAAACCATGAGATACCCCTTCATACCTACTAGGATGGCTGTAATTAAACACCACCACCACCAACAGCAAAAAAAAAAAAAAAAAAAAAAAGGCAGAAAATAGCAAGTGTTGGTGAGGATGTAGAGAAATTGGAACCCTTGTACATTGCTGGTAGGAATGTAAGATCATACAGTCTCTGTGCAAGACAGTTTGGTGGTTCCTCAAAAAGTCAAGTATAGAATTACATATCACCCAGCAATTCCACTCCTAGGTGTATATCCAAGAGAGTTGAAGGCGTATGTCCACAAAAAGCTTTTACAGGCATGTGCACTACTCACAACAGCCAGAACGTGGCAACAACCCACATGTCCAATGTCTGTCCGCGGAAGAATAGCAAACAGTATTCAACTGTAAAATGGAATGAGACATTGATACATGTTACAACATGGATGAACCTCAAAAATGCTGTTCTAGGTGACAGAAGCTAGGCACAAAAAGTCACATATTGTCTGATTCCATTTTTATCAATTTTCAAGAATAAGCAAAATTATATAGACAGAAAGCAGATTAATCCTTGCTCGGGGCCATGGGGAGTAGCTGCTTAATGGGTACAAAGTTGTTGTTGGTTTTTTTTTTTTTTTTTTTGAGACCGAGTTTCCCTCTTGTTTCCCAGGCTCGACTGCTGGAGTGCACTGGTGCAATCTCAGCTCACTGCAACCTCCACCTCCTGTGTTCAAGTGATTCTCCTGCCTCAGCCTCCTGAGCGGTTAGGGTTACAGTCATGTGCCATCACACCCGGCTAATTTTCTATTTTTGGTAGACATGGGGTTTCACCATGTTGGCCAGGCTGGTCTGAAACTCCTGACTTCAGGTGATCCACCCACCTCGGCCTCCCAAAGTGTTGGGATTACAGCTGTGAGCCACCACACCTGGCCAATGAGTACAAAGTTTTATTTGAGGGTGATGAAAATGTTTTGCAACCAGATACACATGGTGATTATACCACATTGTGAATGTACTAGACAAACGTCACTGATTTTGTACACTTTAAAATGGTTAATATTACTTTATGCAGATTTTACCTCCATTAAAACAGNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNCCTGTAATCCCAGCACTTTGGGTAGGCCGAGGCGGGCGGCAGTATCACCTGAAGTCGGGAGTTTGAGACCAGCCTGACCAACATGGTAGAAATCCTTTCCCTACTAAAAATACGAAATTAGCCAGGCGTGGTGGCACGTGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATTGCTTGAATCTGGGAGGCAGAGGTTGTGGTGAGCCGAGATTGCATCATTGCATTTCAGCCTGGGCAACAAGAGCGAAACTCCATCTCAAAAAAAAAAAAAAAAAAAAAAAAGAGGATATGTGGACACTATGTCTGGCACTTAAACTGGTGGATTCTATAGAGATGGGATGGGTTCATTAGCCCCATTCTACAGATGAGAAAGTAGAGGCTCCATTACAGCACACAGTGTAGAAGTGGAACCAGGATTGGTCTGACTCTAGAATGCTGCTTTTGATCACTTTTCTATGTTCCTCTTCCTCTACAGTCGACAGGTTTTGTTTTGTTTCGCTTTGCTTCAGATTCTTGGCTCATGCCAAGTGCTGTGTGCCATGGGTACATCACCTGACCCTGAAGAGCCCAGATCTATGTCTTTTCATGCAACCTTGCCCTGTGCTTTCCACATATTCACATCCTTCACAGTCAATCCCACCCTGGCCACTAGGCCAATAGGGACTCCCCACATCCCACTTACAGGGGGGCAAATATTTATAGCCAAAAGAAAACAGAAGATGTGGGTTTGAGTCACAGTTCCACTATGTGGTCATGGATGAGTGCCTTCAACCCTCAGTACCTCAGTTTCCCTAAATGTGCAGTGGGAGAGCATGAGAACACTTATCTGATGTCTTCCCTGGGGTTTTGTGAGGATTAAACACACCATGTAGGGGCAAGTGCTTTGAGAATGGAAAAGCACTGTGCAGACATGAGTGATGTGCATGATGGTTATTGTTAGATGTTCTCTCCTGGAATCAAGTTCAAGCTTCTTGCATACTCAGCAGAGAACAGACCCAAACTCCCGAATCTAGTGCTGTGGCATGTGGTTGGTGCTCAATAATGATTTGTTGTGTGAACAACTGCATGAATGAGTAGTAGGTCAATGACCTCAATGTCGGCCTGGTCAGGATTTAGATTTCTTGTCTTTGTGTGTGCTCAGCCCAGGACTGAATGCACAGCAGGCTGTCAGGAAGTAGTCATGGATTGATGTGTCCGTATTCGCCATAACCAAGCAGGAGATAGATGATTTCGTTCTGGTCTCTGGATTTTGGCTGCATTTTCTCTCATAGTAGGAATTATTCCCGGAAGATCCAAATGCTCAGCTTTGTCCTCCTCTCATCCTCGTGAGGCGTGTGATCCAGGTGAGAAGCAGGGAGAACTGCCCTTCCTGGTGGGAAGTTGTGGGCCATCACCTTAAGCTTGGCTTGTAGTGGTGGGAGACCTGTGTTCCTTCCTTCCTGAGCCCCACTTCCTCTTGATTTTATTGTATTTTTAGCAGCACTGACCTGAAGCTTTCTGGGTTGCATGTTAGAGGCAGCACTTCTTGCACAACCTAGGGGAGCGTGAGTATCGTTTCGGTTCTGATAGCAGGATGGATTGTTATGTATCCTTTCTGATCCAGGCTACCAAAACCTTTAGATGTTAGGATGGATTATCTCACCTTGCACAAGACAGTGAGTGCTAGAGTTTAAGTTTTCTCCTCTGCAAAATAAGGAGTGGCAGTGACACTTACAGCATCTCTCAAGCCCACTTTGGCCCAAAACTTCCATGACTGTGGCAGTCTACAGTAAATGTGTTTGATAGCCCCTAGTTACAACTCTCTTCTGTCTCTTCCCCTTTCTGCCTGCGCTACCATCTAATCCATCCACGCAACCACCCATCCACCCACCCACATTTCCTAGCCAGCTCTCTGGACCAGGCCTTGTGTTAAGTCCTGAAGACACACAAAAGGCTAAAACAGCCCCTGGTCTTAAGGACTCACAGATCATGAGGACGCGATAGATACTGGAATAGAAGGCAAAAGTCAAATGTCATGAGTGCTGGGATTCAGAAAGCTGCAGGCTGCTCTGGTAGCAATAAAGGAAACCAGCTCTCCCTTGACATCCCTTTCATGAGGGTTATAGCCTGGATCCTGTGATGACCCAGGACAGACTGGTCTTGATCCAGGGCAACCATATCAGTGACCTCAAGAGGCCCCTTTTAGCCACAGTAATCTATGATGTGGAGTTCTCAATTGCTGGCTTTCCTGGAGAAAGAGAGAAGGAAGAAATAGAGGGGCCGGTCAGCCCTCCTGTACATTTAGTTTGCGGTCTCAAACCTCTGTTTCCTGGAGCTGCAGGCTGTATGTGTGGGAGGTGCACAGCAGTGGCTTCGCCCCCCCAACGCGCCTGCAGCCCGCTCTGGGGACAGCCGTCTTTTGGCAGAGTCTGCCTCTGCAGTGGTCGCAGCTGGCCCAGGCAGACCTCCTCTCTGTCCCGTTAGTCAGCGTCTGGTGGCCAAGGCCAGAGTGGAGCCTGTGTTTCCGACAGGCCAGCTGCCCCTCAGACTCAGGCAGCGCCGTGATTCTGAGGGTGATGCTGGCGTTCGCCCCTCAACCCTGTCCCCCACAAGCAGATTACGCACAAGGCAGCATTTCTAATAAGCAGCCTCTGCTTGCCCCGTAGCAGATGAAACACTGCGTGTAAGAGTGGGTAATTTTGGGTTTTCCTGATGAAAGTAGTTGACATTTGTGCTGAGACCTCATGCGCTCTGCAGCGCTGCCTTTCATCTCTGCTCTCAAAGCCCTGCTCATCTCTGCCATGACTCGGGGGCCGCCTGCGCCACCGGAATTCAGTTCGGCCAGTGGTGAAATATAGAGGAAATGGTGGAATGACCCCTGAAGGCACTGGATGGGGGAGTGGAGACAAGTCCTGACTTTCCTGGTGGAGGGGATGTTCCTGGGGGTGTGGAACTGTGTATCGGCCCATGCAGCACAGCCAGGGAAAGAGTCTGCATCTTGGAGCTTGGTATGGCTGCCTAGATTGGAAAGGCAGCTCCTCCACGGACTTGCTCCGTGAATGCAGGGCATCCTTTCTCTTCCCTGATCTGTGTCCTCATTTGTCAGTGGGAATAATAGAATAACATTACCACCAACGACGATGGCTTTCACAACTGGAACCACTAGGCCCTCAGGAATGTTTACTGGCTTCTAGTCTCATTGATAAACTGAAGCCATTCTGCCATAGCTCTAGAGAACTGGCACTAGGGGCTTGCATGATTCATCTGAGTTCCCCAGACAATGCTGGCACATAGTAGGCCCTCCATAAAGTAAGAAGGGACACTTTGCTCCTGACATCCATACAGCTCCTCTAGCTTTGCAGACAAACCCCTAGAGAGAAAGAATGTGAAGGAACAAAGGGTCAGGTTAGGTTGTGCAACCTTTCTGATATGCATTTGTAATGCAGTGAGCAAATGCACAAGCCTTGAGTCGCTGCATTCTTTTCTAACCACCCAAGAGATAAGTTGAACCCCCACTCGTAGCAACCTGGCCACTTGTCTGTTTAGTCAGCCCTGGAATACCTCCACTGACGGGGCACTCACTACCACTGAAAGATGGTGTGCAGAATTCTAATGTTCTTCCTCTCGCGGGGTCGTGGGGGCTTTCTTCCAGTTCTCTGGGTTCTGATCGTTGGGGCTGTCCTGACACCCTTCTTCAGATGACCGCTGTCAGGTTGGTGAAGGCAGTGCGCGTTGGGCCTTCCCTCCCTAGAGATGTGATTCCACGTCGGGTACCAGGAGCCTGGCCACCCCTCAGCTTCTGCTAACCAGGGAGCAGTGAACCCCGCTTTACTTTTGTTGGCTTGTTTATTTTCTAATGTCACCTGCCTCTGCACTTTAAGTAGTATTTGGGCTGCTATGGAGTGTGCACATTCTAACACAGCACCTTGTCAGCTGGCTGAGAAGCTGAAAATTCTCGGCATTCCTCCTTGATGTCAATTACTTCAAGGAGCAGGAAGGTGACTTCTTTTAACAAGTGGAAAGGATTCAGGTAACAAAGCCATTTCCTCTTCTTAACCCTCTACTGTCCAAAGTTATTGACTTAGCGACACAGTCTGTTTATCTGGGCTTCACGAGCACGGCTTTCGACACTGAAGGCTTCTCCCCACTTTTGTGCAATGTTATATATTTTTTCTCACTCTTCATCCAGTCTGAGTCCCGTCTGCCCCCTCCCCTGAGCAGTCACCATCCTGCTACCCACTCCCCCTCTATTGGCCACTGTGGCATAGGGTGGTGGAAAGGACGCTGGACTGAGAGCCCAGAGATCAGATGTCTGACCTTCCCTCTGCCTGGAAGAGCTGCCTGGCCTCTGATCACGGTCCCTACCTTCGTTTTCTGGCCTCACTCACTGTGGCCCACCATCCACCAGTCCAGGTGTCCTGGGCACTCGGGGAACGTCAGAACTCGAAGGAAACCCTCCAAGCCCTCCCATGCAGGCCCACCATTCCACTGTCAGGTTTTCTTCCCTTTCCTTCTCCTCTACATTTTGTGCCAGCAGTTTGGGGGTCTCCTGAATCTTATCCCTTCGCAGCGGTAGGCAGGTCCAATTTCTGCCCAGTCACTGAACATGAAGAAGCATCTATACCCCGAGTTAAATCCAAAACACTTGGCCTGACACACCTGCCCTTCAACTCTCCCCCAGCCTCTCCTCTTGTCCCCAACAGTGGTTCATCTTCTAGCCACACAGAAATTGAGGGGGTCCTGTGTTATCTGTGTTCCTGCAGACAGAGCTTCCCTAGGACAGCAAAAGTCATCCTAACATAAAAATATGCATGAATAAACTCACTGCCAACATTCAGCCCACCCACATCCAATCATAATCAGTCATTTACTGATCCCCAGACGTTGTAAACATCTGTCAGTCCACTGCAAGAACAGCAGAAACTCCTAGCTGACCTCCATTTGGCCTACTCACTCAATTAAGTCATCTTACTCATTCGCTTTGTAAAAGCAAACTGAGTGAGGCCCCAGGCTCATTGAAGACTCTGTGCCTTACCCAGAACCCCAACTTTCCAGATTCAATATTTTTTCTATTTCTTAGCTGTGTTACCTTCCCCAACTTAATTAACCTCTCTCTCCCTCCATGTTCCATCTGTAAATGAGACTAATACTAGTACCCACCTTCTAAACTCATTATGAGCATTAAATGAATTAGTACGTTTAAAGGCTTAGAACAGTGTTTTATGATACGATAAACACTCAATAAATGTTAGCTATTGATATTGGTGTGCCCAGAAGGCTTGTTACTACTAGTTGATTTATGTCCTTCCCAAAAGTTGTTGTGTTGGTAATTAAGTACGACATAAACTAATCAAAATTGACTTTATAAAGAGTTGTTTTATGAAAAGTTTAGTACTTTGGATAGAATGGATAATATTGATTTGCTAAAAAAAAATTGTCACCAAATAACTTAAAGCCAAAACAGCTGTAAAAAATTGTAAAACCATAGTTTGTATTCCATATGCTTTACAGGTGATTAACTTTGCCACTGCTTTAAAGAAACTGAAACCAGCAATTGTAGATGTTGACTTCTGAGTGTGTATTTTGCATCGAAGATCATTTGCATCTCTAGTCACCGTGCCAAAAAAAGATCCTACCCTTTGATTGGTTAATAAATATCCAACTATAATAAAATATTTAAGTGTTGGTCCTTAATGATTGCCTACATTTTCAATGAAATGACAGTGGCACAACTGAGGAACAGGCGTTTTTCTCTCCAAGGCAGATCAGCTGCCACAAATTGCACGTTTTGTACCAGCTGCAGGGTTTCCTGGAATCAGCAAACGCCTGTGAGAGGCTGCATGAACCACACACGCTTACTGACACCTCCTGTGTGCCGAGCGCTGAGTAGTGCTGAGGATATAGCAATTGGGGAGCACTACCACAATCAGCGTTGTTAACCGTCGAGAAGAGAAAGGAAAGATGATGTCTCTCTATGCAAATCAAGGGAAAGTGATTTAAAAATGTTAAAAAAAAAAACTTAACAGAGCTCTTCGAAAGGTGTTTTGCAAAATGATTCCTTGGATTAATGATGAAGGAGTGGAGTGAAGGAAGTTTATATTTTGTGAGAAAACGTGTGCTAAGGAACCCCTCGACATTAGATTCATTCTGTACACAACTCAGCAAATTAGATCATAGTTTAAAATGATAATTTCAGGGGCCGGGCACAGTGGCTCCTGCCTCTAATCCCAACACTTTGGGAGGCCGAGGAGGGAGGATCATTTGAGGCCAGGAGTTTGAGACCAGTCTGGCCAACATATCGAAACCCCATCTCTATTAAAAAATACAGAAAATTAGCTGGGCTTTGTGGTGCATGCCTATCTTCCTCTCTACTTGGGAGGCTGTGCATGAGAATCANNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNACTGCAACCTCTGCCTCCTGGGTTCAAGCAATTTACCTGCCTCTGCCTCCCGAGTAGCTAGGACTACAAGCATGTGCCACCACGCCCGGTTAATTTTTGTATTTTTAGTAGAGACGGTGTTTCACCATATTGGTCAGACTGGTCTTGAACTCTTGACCTCGTGATCTGCCCGCCTTGGCCTCCCAAAATGCAGGGATTACAGGTCTGAGCCACTGCACCTGGCCAGTTCAGGTTTCAAAGTATAACATCAATCTTATTTTATGTATAGTTTATGTGTAATTATAAATTGTATACTAATAAAGTCATTTTTATAATTCTTTATTTCTTTTTCCAAGATACCCACCCCCCCCCCACCAAGGAGGGCTAGGACAAGTGACAAAAGTCACCCCAGATCACAGCCAAATGGGTAGAGCTAGGAATCCGAAGTAGGTGATGAAGCTTGATTTTTCAAGATGCTGCAACCCCTCTCCCCCATATGCTACATTAAATATCTGCACCTATTTTAAGTGCGTTCTTTTCTGGGGTAATGAGGTTCTCTTCTGCCTCAGTTTTCCATGGCTGCAGAGCTCCTGCTGTTCCTTCTGCCTAGTTCACTCTTCTTTGCCTTGACTGCACCTCTCTGAGCTACCTTCCTACCTCCATCCTTGCATTCATTAGCGGTTTCTTTATGTGTCCAGCTCACTGTGGGACCCAGGACTCCTTGAAGAGGGAGATCTTGCTCATCCATCTGTGTCCCCCACTCTACTGCCAACACAGTGGTAGGAAGGGAAGGCGGCAGGCTTAGGCGAGGTCCTGCAGGCTGGACAGGATCTGTCACCATTACTTAGCCCAGGCCCATCTCTTTACTTCCAGACCAACTGGTGTCACCATAATGCCTTCTGGCAATTTGAAGATTCTGGCAACCTCTTACCGGATCCAGCTGGCAGCATAATCCCTGTGCATTAGCCACTTTCAGAGGTATCTCCGCCCCCAAAAGAGTCACGGGAGTCCCAGACATGAAGGAGCATTAGTGGCCATCTCCCCACCTTGCTGTATCAGCAAAACCGCTAAGCCCTGACCCATATTTTGGGCAGTGCTCACCCTATCTCATTTTATCTTACTGTATATCTCGTTTGTATCATTTTATTAGGTATCTTATTTTATCTCATTATATGCTAATCTCATTTGCTGGGTAGACCAGTCACCAGGGCTGGCACAAGTGACTGGAATTGCCCAAGGTCACAGACAAGTGACCTTTACAGATAGGACTCCGAAGCAGGTGGCGGAGTCACCGTTGAGTTCATCATAGCGATGCTGGCTGCCTCAAAGTACTGTTTTAGTTAATGCTCACAAGCAACTCTGCGAAGCAGACGGGCCATTCATTTGTGCTTCACAGTGTGGGAAACTGAGTCACAGCAGGTTCATGTCACACAGCTGATAAATGACAAAGCCAGATGTGAAGCCTGTGACTTCCATTCCAACATTCATCTTTGATGAAGCGTTCAGGTTGGGGCCTGGTGTGGGACATGCTCAGAGGAGGACGAGGAGGATGATTTGGGGGAGGCCTCAGAAGGCGTTCCTGGTCTGAGTGTGCTGCTCTCACTGCCTTGGTTTGGGTCCCCGCTTCTGAGCAGGATCTTCTATTGGCAGACGGTTCAATCCAGTGGGTGCCATGAAGGAAGATGTCTCCCCAACAGCATCACACTCTCACGGACTGTTCACATCACATTAAAAGCGCTGAGACTCTGGCTTTTGGTGAAAACGGCTATTTTGTCTTGTTCCACGGGAGCTGGGAAGAGGAGACTAAACACAGGAGCCTCCCCCTAACCCACGGGCACATCGAGAAGGAGGAAGGCAGCCCATGCTGGGCAGCAAAAGGGAGAGAAGGCGAGGGCCAGAGCCCTGGGAAGTGTCAGATCCTGGTGTGCCGCGCTTCTCCCAGGTTGTATAATCAGCTGTCACTTCAGCATTTCCCTGCATCAGCCTTCCCAAGTACAGATTGAACATTAAACAAACAGTGACGGCTTTATAAATATTTAACTCCCACTGTTTAGGAATTGCTCGGGGCAGGAGACAAAATAAGAGTTCCTGGCTGTCTGCTCCATGCCCCCTCTGGCATGGTGTTGGAGGCCGCCGCTCAGAGATTTGCCGAGTCGTGGGCAGCAGCTATTCTCTTCTTCCTTTCCAGGGGGATGTGTTTGGGGACACATGTCTGTGTGTTCATGGAGCTGTTAGGGCCTCTTCTAGAAGCCACCAGTTTGCGTTTTCATACAGTGGCTGGGATCCATCATTCCTGGTGTTATTCCTTCACATCAGAGCAAACTTCTTCCTTTCTTTTTTATATATAGCACCTTTATTGAGATATAATTCACATATAATTCACCTGAAACTCACCCATTTAAGGTATACAACACAATTTTTTTTGTTTGTTTGTTTCTTTGAGACAGAGTCTTGCTCTGTGACCCAGGCTGGAGTGCAGTGGTGCCATCTTGGCTCACTGCAACCTCCGCCTCCCCGGTTCAGCCTATTCTGCTTCAGCCTCCCCAGTAGCTGAGACTACAGGCACACACCACCATGTCTGGCTAACTTTTGTATTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCACTCTGTTGCCCAGGCTGGAGTGCAGTGGCTCGATGTCGGCTCACTGTAAGCTCCGCCTCCCGTGTTCATGCCATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGCGCCCACCACCACGCCCGACTAATTTTTTGTATTTTTAGTCGAGATGGGCTTTCGCCGTGTTAGCCAGGATGGTCTTGATCTCCTGACCTCGTGATCCGCCCACCTCGCCCTCCCAAACTCCTGGGATTACAGGTGTGAACCACCGCACCAGACCCCAACTTTTGTATTTTTAGTAGAGATGGGGTTTTGCCACGTTCCCCAGACTGGTCTTGAACTCCTGGCCTTAAGCGATCCACCCACCTCGGCCTCCCTTAGTGCTCGCATTATAGGCAGGAGCCACGGTGCTCGGCCAACACAATTGTTCTTAATATATTCATGGAGTTGTGCAACCATCACCACAATCAATTTGAGAGCATTTTGATCACCCCAAAAAGAAATCGTTTTTATTACCACTCACCTCTTTATTCCCACAATTCTCTGCGTGCTAAGAAATTGTTGAGCTACTTGTACTACAAATATACCTATCCTGGAATGGTCTTTTGTGCCTGGCTTCTTTCACTTGGTGTAATGTTTTCAAGGTTTATCTGTGTTGTAGCATAGATCAGCATGTCATTTCTCCTTAGGGCTGAATACTGTTCCCTAGCACAAGTATATTGCATTTTTAAAAATCTACTCATCTCTTGATGAACATTTCGGGACAGCAAAGCTCTAGTTCAAAAATCAAGATCAAAAATCAAAAAAATATAGTTGAAAAAATCAAAAAAATCTAGTTGAAAAATCCAGCATCATGTGATTAAGGCCAAACTCAACTTCACAAAAGAGAGCCTCTACTATTTTGGGAAAGATCTAGAAGGTTATCTCTAACCATATGGTGGATGTTACAATGTCTTCAGTGGACACGCCATTCAGCTTTTATTCACCACTTACCATATGCTCGCCACTATGGTAGCATTCATTAATTAATTTATTGAAAATAATTATTCACATTATATAGTCTTGTGAAAAGATTTATCAGAGGCTGTTCTGTGAATTTTAGAGGTTTTTTGTTTTTGTTTTTTTTTGAAATGGAGTTTTACTTTTGTTGCCCACGCTGGAGTGCAGTCGTGCCATCTCGGCTCACCGCAACCTCTGCCTCCTGGGTTCAACCCATTCTCCTGCCTCACCCTCCCAACTACCTGCCACTATAGGCATACACCACCATGCCTGGCTAATTTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCGGGCTGCTCTCGAACTCCTGACCTCAGGTGAGCCACCCACCTCGCCCTCCCAAAGTCCTCGGATTACAGGCATGAGCCACCGTGCCCACGTGAGTTTTAGACTTTTTTCGCCTCTAAGAATGCGACCATGAGTTTGTGTTCTCAGCTCGTTTCATTTGATTTCAGATGTCAGCTCTCTTTAGGAGAGAGGCGTGGAGAAAAGGTGGGACTCTCTGCAGTCCTGTTCTTGTTCTGCCCACTTCCCTCCAGTCATGGTCTCTGGCCGGCTCTCTTCTCCCCAGAGTGGTTCTTTTCCTGCCCCTGGTGTCCCTCTAAGACCCAGATGTTTCCAGCACCCATTTGAGAGGCTGATTCAGCCCAGGCAGTGTCTGGCCTAGGGAAGGTGACTGCAGGAAATGTTAAAAAATGGGGGCTGTTATCATGCCTGAGCATCGCACAGTCCCTCCGTTGTGACTAATTGTAGTGGTTGTTGTTGAAGGGCTGCCCCAGGTCCCCCTCCCTGGACCGGTACACTCACCCCAGCTGCCGAGACGGCGGCTGCTAATGTCCACTGCTGCTAATGTCCACAGCACCACTTCTCTGGACATTAGCCTTCCTCCAACTGGAGCTGCTTCATCCGGGAACTTCCTCACCCTGCACCACCCCTCGCTGACTCAGCGGTGCAAAGGGCTCCTCCTCCTTGTTTCCATGTGGGGTAAACTCCATGGTGCGGTTCATGTTCCACCCCATCCTGTGGATGGCCTGAGTTGGTCCCCAGCCGAGACCACCTCCTTCCCTTGCCTGGCTCTGCCACCTTCCCTTCCTTTCTCCTGAGGTTGCTCCCTGTTAAATCACACAGACAGACATTCCCTCCTCAGGATCTGTCCCCGGGTGCCCACCCTCAGACACTATCCGGCAACACGTTCCCTTTCCTGAGTCCCCTCTGATGATGTATCTGACTTGGAGATCCTTGGCCTGCTCCCTCTCTTTTCAGTTCTCTTCTGGAGAATAGAAGCTTCCTGGGCTGGCCTGTTGAGTGTTTTGTTTGGTTGGTTTTGATTTCCAAGTCTTTTCAGGCTAATCGGACACGAGGAAAGGTCTGCATTGAATCACAGCCTTCCCACTGTTCCCCCCTTCCTTCCCTCCTCCGTTCATTCCCCCGAACATCCTTTTCTCTGCCGACAATCACCTCACCAGAAAGGGGAAAAGGACGTGGGAAGGCTGCATGGGAAACTCATGGAACTTGGTACCAAACAGCTCTGGGTTCAAGTCCGCGCCCTGTTGCTCAGGAGCCAGGCACTCAGTTGTGCTGGCTTCTCTAACCCCCAACTTCTTCTATGAAAATGGGACTATTCGTCTCTACTCCTTGCATTATTCTCGGGATCGGAAATAATCTGGCTCAATCATGTGGTGCAGTGACTAGCATCGACGCGACACCCTCTCCACACAGGCTGGAAAGACATCCAGAAGGAGTCCTGGGCTCCCTCACCACGCAGGGGCTCAGCCTCCCCAGATAGTTGTCATCACCCATCCAGGCCCGTTTCTGGTCTCATTGCTTTTGTTCATGTACTTTCCTCCTCGGTTGCTCTTCCTTTTCTCTCTGACCTGTCAAAAAGCCCCATTGTAAGCAACATTTAAATCCTACCTCTTCCATGAAGCCCTTTTGGATGCCTCTTAGGGGGATGAGTTCTTTCCATCCTAGCACTGCTTGCTGCATGGTCCAGGATCTGTGGGGCCTGTCTTCTTTACCACTTTGCTCACTTCATGAATGTGGGGGTGTATGAAGAGTGTGATGAAATTAGAGGCTATGTTCTGGAGTCAGACTGATCAGTACTGGGATTCTGGCCATACCCCCTCCTTAGCTGGGTGACTTCAGGCAACTGACTGTACCATCCTGAAAGTCATCTGTAAGCCGTGCTGACCCCCCAACCACAGGACACTTGTGCCCGCTGCACGTGCTCTGTCAGCAGTGACTTCTCACTACCTGGCATCCTCTGAATTCACGAGCAGTTTGAAGAATGACCAAATACTGAGCAAAGCTCATAGGATTAAATACACACAGACCTCTGTAAGTTAACACCAAGCTAAGGGTTAAATACTTTACAAAAATTCTCAGTGCGGTTGGTGGGTGAGAACGGCTGTCGTCCCCTCTGGCTGCCTTGCCAAGCTGGTAGAGGGGCCATCTCCCACTACCTACTGACAAAGATTCTTTGCTTGACCCAATTACCCAATTTAATCAGACACTTAAGTCTTTTCCTAGCCCCATCTGTGTACTTCCTGTAAAATCTAGTTTTAGCAAAAAACTCTGCTGAGTCAGTTTGGTAAGGACCACCGGCCGTCAATATCTTCCATATCTGATAGATAGGGTTCCTCATCTTCTACCACCCTCCAGATGATCTCTGGTCACCCTGGCCTGCCTTTAGCAAGAATCTTGATAGGTTGATTTAACCAGAATCCCCCTTACTCCTGATGTTGCCTGTTAGTAATTTTCTATCCTCTGACCCCCCACCCTCCTTCTTGGCTGTGAATTTCCACTTGCTCAGGCTGTATTGAGTTGAGCCCTATCTTTCTCCTACACTGCAAATTCCCATTGCCGTGGTCCCTATACCTATCAGGATGGTCCTGAATTGTCTTCTTTATCATCTGCTCTGCTCTCCCAGAGCTTAAGCCCAGGCAGCTGAGTTAAAAGTGTGACCAAATGGACCATCTTGTCCCTCAAAATTGGGACCTAAGCTCGATTCCGAGATTTAATCATGGCAGAGGAGTTTACTCTGCTAACCACCATCACCCCACCCTATCCCCCAGAGGGGTGCGGTGAGTAAGGGGGTGGCAACTGCTTGTTTCCAATCTCCCATCTCTCTCTGGCCCTCCTCTGTCTCTGGCCTCCCTTCTCCCTTTGAAAGGGACACAGTGCTGCTCACAGCCTGTCCTGCTGCGGTGGCTGCAGAGAGGGGCTGACAATAAGCCTGTGTCCGAGGCAGCCCTCCAAATACAGCAGGGCTGGGTTGACCTTTAAATAGATGGGCTCTGGGCCACTCAGTTCCTGGAAGTTTGAAGAAAGTCAGCCTTTCAAGTGATCCCACTTCCAACCTCAGGAAAGATCGCTGTGTTTGTAAAGGGTATAATTTACTGTTGCTTTTGCACTTCATGATATGCGCCTGCACAGCCAGTGGGAGCCAGCATGCCACAATTAGGAGGGGAAAATCCTCAAGTATTTTAATATACCCCTACTTAGAAGCAAGATAAACATATGTATTGTACTTTGGGACAGAAGCAAGGGGGGTTTAGCGGGTGGGAAAGGGAGAGTCCTGGCATTGCATGAAAGGTCTTTTTAAGCTGAACTCTGAGGGTTTTCAGTTTTTCATTTTTCTGTTTTTTTTTTTTTTTTATTTGTAAGCAAAGCTGGCATGAGCAAATGATGCCAGGATCTACTTGGCTGTGTAAAAGCTGTAGTCCCTCCTCAGACAGGCAGACTCCTAGAACCCTCCCTAAGCCATAAACTAGTACACCGTTTTGCCTCGCCCAATTAAAAATGATTCGGTGTGGCTTGTCATCACAGTTGACTTAGATGATTTACTTTCTTCCAGGAAATCTTCCTCCCAACTCTTGCTTTGCAATTAGGCAAAAGAAAAATAAATGTTAATATGTTCTGTGCTCCCAGGGAAAATTTTTTTAAAAACAAAATAAAACACTTTGGGAGGCCGAGGCAGGCGGATCACGAGGTCAGGAGATCGAGACCATCCTGGCTAACACGGTGAAACCCCGTCTCTACTGAAAATACAAAAAAAATTAGCCGGGCATGGTGGCGGGCGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAGGCGGAGCTTGCAGTGAGCCGAGATCGCACCACTGGACTCCAGCCTGGGTGACAGAGCGAGACTCCGTCTCAAAAAAAAAAAAGAAGTGTCAAGGTCATGAGTGTCAGGGAAAGACTGAGAAATGGTTCCAGACTGAAAGACACTAAAGAGATGTGAGAATTAAATGCAAAGCTTGATTCTGGACAATTGTCAAACCTTGGATCGCTCGCAGCCTTAGATGTTAGTTACGTATCTGTGTCAGCTTCCTGATCTTCCTATACAACATGGTCCTAAGGGAGAATGTCTTTGCTTTAGAAAAATACACATGGAAGTACTCTGTAGTGATACGGCTTCAGGTCCACTACTCCCTCTCACATGCTGTAGGGGAAAAGGATTTGCTGTGTGTTCCCAACACGTTTGTGATTATTTCACAAATAACAATAATTAAAAAAAACCAACCTCTGGTGGGGCGGTGCGGAATTATTATTATTTTTTTTTGGGACAGAGTCTCACTCTGTTGCTCAGGTTGGAGGCCACTGGCATGATCTTACCTCACTACAACCCTCAACTCCTGAGTTCAAGCGATTCTTGTGCCTCAGCCTCCCAATTAGCTGGGATTACAGGCATGCGCCACCAGGTCTGGCTAATTTTTTTGCATTTTTAGTAGAGACGAACTTTTGCCATGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAGGTCATCCAACCACCTCGGCCTCCCAAAGTGCTGAGATTAGAGGCGTGAGTCATCATGCCTGGCAGTAATCTTTTCAGTGGAGAATAAAATAAACCCGGGTTTGAATTCTGACCCTTTAAATTTACTCAGGGTTTCACTTCAGCCAGGGAACATAACCTTTCTGTGCCTCAGTTTCCTCATTTTTCAAAACAAACATGGTGTGTGTGTGCATCTCCATCTATGAGTTGTTGTGAATAGGAATGTAGGGGCCCCAGCAGGGTGTGTAAAGGTACCAGTTCCTGGGGCGTCAAAGGTTTTTCTTTCCCTTTGTACCCCCTCACTGACATGCCCACGTCTGTCTGTGTACAGCAGTGGGTGGATTTACAGACTCCGCTGAGAACCCCCTTATAGCATATTTTCAGGTTCGTGATGATATCATGGGCTGTGACCCTGGGAGTTTAATTGGAATGAATTTCAAGGTTTTGTTAAACTTGGCTAGAATCTTCCTATATCTCCAGCAAGATATTGATGGGGTTTTTGTTGTTGCTGTTGTTTTTGAGACAGGGTCTTGCTCTGTCACCCAGGCTGGAGTTCAGTGGTGCCGTCACTGCAGCCTCAACCTCCCAGGCTCAAGGGATCCTCCCCTTCAGCGTCCCTAGTAGCTGGGACTACAGGTGCGCTCCACCACACCCAGCTAGTTTTTGAATTTTTTTGTACTGATGGGGTTTCACTATGTTGCCCACGCTGGTCTCAAACTCCTGGGCTCAAGCCATCTGCCTACCTTAGCCTCATAAAGTGCTGGAATTCCACCTGTGAGCCACTGCACCTGGCCAAGAACTTGGTGTTTCTTATTTCCAAGCTTATCTCCTCTGTTATTTGCTCCCAGGGAGACCCCTTTTCCATTTATGTTTCCAGGGTGCTGGGGGGAAGTGATTGCCCTCATCTCTTTTGCCCAGCCACCAAACCCAGTGCAGACTCTGCTGAATGCAGGCCCCATCTCTGTATTTTACTTATTCCATTTCCTGTCTTGAAGGTGGGGGCACTATGTTTATCTCTAGGACCCTGACTGGCTCATCATTGAAAGCTTATTTTGTGCAAAGCATTGTTCTGAGCACTGTGTGTGTATGATTCTACTTCATCCTCTGTAACCCTAGCAGTCCGGTCAAATAGTATCATTTTATAGACAAGGCAACTGAGGCACAGAGCAGCTCAGCAGCTTGCCCAGATCACACAGCTGGAAAGTGGTAGAGCTGGAATCTGGATGGGTGCTCGCAGCCTGGCCTCAGAGTCGGTGCTAACCACTGAGCGGCACTGCCACCCAACGGATGGGAGCCTGCAGGATGAGGCCATGGGAATTGATTTCACTCAGCGCGAGCCAAGCAGAACTCCCGTCCAGACCTCTGTCCACCACCCTAATAAAGCCAGTGTTTACACAGGCTGGAGGTGCTCATCAGATGTTTTTGCCAATCCCCAAATACGGCCACGGCCAGAAAGTGAGAGGGGTGCCTATTATGTAACGCCCTGCGGCTGGTCCCCAGACAATGCCACTTCCTCGCTTGGCGCTGTGTGACTGCATAACAACGGCTTACTCATTTCCTCTGCAAAACTTCACAGGGCCTCTTTGCCCCATTTCCTCCTCCCACCCCATCCTCAGGCTTCCTCTGTTGAATTTTCTCCAGATTCCTGGGAACACCACCATGGAGGGCCTGGCCTTTGGCGGTGGACAGTCTGTGGCTGGGTGGGAACGTCAGGAGTGGGGCCTGCCTCTTTGCTGGGAATGCCGTGCACTCCCAGCCCACTTGCCCCATGCCAGCACTCGAGGCAGGTGAGGCCCAGCCATGGGTATAAGGTGCTCCCAGGCCGGCATTAGCCTCAAGGAGGCAGCGGTTCCATGTTTCTGCTCCTCTCCCATTACTAACGGGTGTCTGCTTTAGGTTTGATCTCCCTCCCTTCTGCCCCTCTCCTGGTAAAGGGATGAATAATGAAGGCCTTCCTTGGGAAGTCTGAGATGGATTACCCCAAGGAGGCTCGAACATGGGAGGACATGCGAGAACTATTGTCACATGAGTTTTCTTTCTATCCTGTCTGCAGGACTTCGCAGGTGAGCAGTAACGGAAATCAGCCCCGTTTATTCCTCCCAGCACCTGCCTTATCCAACTCCCCACGCTGTGGCTGAGTCCCAGCCTGCTATGGAAGCATCACTGGACTCCCATTGAACTCTGTGCAGATTCGCTGTTCGTAGACATGGTACCTGATGGACACCAAGCTACGTACAGCTTCAAGGCCCCTTCTTTCTTTCCTAATAAAAAATAAAAAATAAAAACATAATACACGTTATATTTCTATCTTATAATACACATTTCTTATTTTTATCTCAATAAGCTGATAGATATATACTAGATATACACATCTCTCACTGTACATACATACACAAACACACACACACGTACATGCATGTATATGCGTATCTATCTCCAATGCATGTGGAGTGTTGTGCCACGTCATCCTCACATTTAATTTTTCTGTTCTATTTATCATTCTTAAGGATTGTCAGGCATTAGGGATTTATCTATAGCAATTTGGATCTTAGCAGTTCTTTTCATGGGTTATCTTATTTTTTCCTTCCAACAACCTTGGAGGCTATAAAAGGGCATATTATTGCCCTTTTATAGATGGGAATTAATTTATTAGCAAACTCAGTTTCATGATTTTTTTTTTCTTTTGAGATGGAGTTTCGCTCTTGTTGCCCAAGCTGGAGTGCAATGGCACGATCTCGGCTCACTGCAACCTCTGCCTCCCGGGTTCAAGCGATTCTCCTGCCTCAGCCACTGGAGTAGCTCGGATTACAGGCATGCCCCACCATATCTGGCTAATTTTATATGTTTACTAGAGATGGGGTTTCTCCATGTTGGTCAGGCTGGTCTCGAACTCCCAACCTCAGGTGATCCACCTGCCTTGGCCTCCCAAAGTGCTGGGGTTACAGGCGCGAGCCATTGTGCCTGGCCAGTATCATGGATATTTTTAAAGTGCTTGTTGTGTGTTGGGCACTACTATGTCCTGCATTTAGAAATAGAACTCATTCCTATTCTCTGCTTTCCCATGGAGAGAGGCACAAACCTGCGGGTATAGGTGGGTATAGTTTCTTAATGTGCACACCATCGTAAAGTGGAGACCCTGTGCGTGAGATGTGTGCTGTGTACAGGGTGGGCAGGAGAGAGACTGGTGAGGGGATGATGCCCTTATGCTGGAAGGGGCAAGATGAAGCCTCTCTGGGTTTGGTGGGACCTTGGAGACATCTGCCTAGTGTGTGGTCACCCAGAGGCCAAGGATGTGCTGTTTCTACTTGCTTGCTGCTTTCTCTGGGAGTGGCCATTTCTTCCAAGGCAGTGTAAGAGCCTGGGCATAGGAGCCAGGCAGAACTGTGTGGGGATGTTGCCTCCATAGCTTTCTAGATGAGCAACCTTAGGAAAGTTTGAACAGTTTCTCTACATCCTGGGTTCTTCATCCATGAAATGGGAATTATTGTTTGAGCCTCTAAAGTGAGACAGTCAAATGAGATGGGCATTTGAAGCCTTCAGCAGGGTTCCAGCCTCACAGCTAACTCTCAACTAGCTGTGATGGTTACAGAGCTGTAGGTTGCTCATAAGTCAACATTGTAGTTGCTGGAGCCATCAACTCAGCTATAGGATACAACACTGAGCCCTTTTCACTATCCTTTGATGGGTCTCCTTTTCCCTAGTATGGGCCATCGGCTAAGGTGATTGAAAAAGGGCCTTTCATGTTTTCAAAGGGGCAAAGAAACTTCAGTAGTTGGTTGGGCATTTTATTCAGTAGAGGTGACTCCATGCAGTTCTTTTTGGGGGAAGGATGCTGCACATTCCAGGGTTTAACAAAAATTTATTGAATGCTTACTTTGCCCCAGATACCTGTCTTGGTAAAGGTGATAAATAAGACAGCCTCATCCTCATCTTCATCAAGCCACCAGTCTGGTGGTGGTGACTGGGGTGGGGACTGCTGAGGCATTGGGCCCCTTGAAGCCTTCCCTCTGGGTGTCTTCCTCCCCAGGATGGTCTGGGCTCTCTCGGGATGGGAGGAAGTTGGTCTGAAAGTGCCTCAGTGATCGCTGAAATAGGTTTGCCAAAGATAGAGGGGAAAGAGATGGCCAGCCTTTGTTTAGGGACTCCCAGAATGGTCTTAGGTCAGGAAAGAGCGAATGGGTACATTTCTCCCAATTTCTGGGCTGGAGATTCCAAACTGACTCCTTCATGGCAGGCTTCCTTATCTCTGCAACATTTGTTTACATGTTCCCTTCATAGATTTCTAACAGGATGAAGACTTTGTTCCTTGGGGTAAGGGTCTACCTCCAGGTGTGTGGGGAAAAGTTGAGAAGCTGCTAAATTCTTGGCTTTGACTTATCAATGGTTTTTCGGAGGGCCTGGAGCTGGGCTGGGACTGATCAAATTTGGTAATTGCTTAGGCAGCCTCCACTTTTGTTGCTCCTGGGGCCAGATGGCGTTGGGCTAGAAACAATATCGGGGAGTTCTGTTTGGTTTTAACTGCTGTACCTGGGTGCTCTGTTATCCAACCAGGCCCTCTCCTAAGTTCTCTTCTTTTTTTTTGAGACAGAGTTTCACTCTTGTTGCCCAGGCTGGAGTGTAATGGCGCTATCTCACAGCAACCTCTGCCTCCCAGGTTCAAGCCATTCTCCTGCCTCAGCCGCCGTAGTAGCTGGGATTACAGGCATGCACCACCACACCCAGCTAATTTTGTATTTTTAGTAGAGACGGGGTTTCTCCATGTTCGTCAGGCTGGTCTCGAGCTCCGGACCTCAGGTGATCTGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCCTGTAATCCCGGTGCCCAGCCAGTTCTCTTCTTTTTTTAAGCCTCTTCCTTTAGAAGGAAGAAAACATAATCTATATGCTGGCTGGCTCTACACAGCAGCAGGCATCACAAGGGGTTTTTGTCTGCTTTTGCTTCTGAAGGTGAACCCACTATCTATTTAGAGAGGCCACGTCAGGGTGTGTGTGTGTGTATGTGTCTTTTTCCCTAGGGTGGGTATTTTCATTCANNNNNNNNNNNNNNNNNNNNTGTTGTTATGATCCCCTGTTGTAGAAGAAGCAGTGAAGTTTTAGAGAGATGAAGTGCTTTGTCTCATGTCACACAACTGATAGATGACAGAATCACATATGTATTCAGGGGTCTGGTCCAAACCCTAGAAGAAGGTGAGCCATGCATGGCCCGATGGCACAGAGCATGAGCTCTGGTTGCACAATCGTGGGAGGTTACTTAATCTTGAGAAACCTCAGTTTTCTTATCTGTAAAATGGGACAGTATGTATCCCAAAGGGCCATTTTGACCATTTATCAAAGTCAGTTTCTCCTCCGTATGGAGCGGAGAACAGTGTCCAGCATGCAGTACGTGCTCTGATGATCTTGGCTGTAATGACCATCCTGGTTAGCGTGCATTTGGCCAAAAGCTGGAGTAACTGGTAGCTTCCTGATCTGAGAGGTGTCAGTGGGTGGTGTGGCCCAAAGATTGAGAATCTTGTCAGGGGTGGCCACGTGAGGGTGGAAGTGGTTTGAGTGAGGAATGGTCTTGAGGTAAGAGTTGGACAAACAGTGTCTTCTCTCTCTCTCTCTTTTTTTTTTTTTTTTTTTTTTTTACTTTTTTTTCAGATGGAGTTTTGCTCTTTTTGCCCAGGCCAGAGTGCAATGGCCCGATCTTGGCTCACCACAACCTCCGCGTCCCAGGTTCAACTGATTCTCTTGCCTCAGCCTCCCGAGTAGCTCCGATTACAGACATGCACCACCCACGCCCGGCTAATTTTGTATTTTTAGGAGAGATGGGGTTTCTCCATGTTGGTCGGGCTGCTCTCCAACTCCCGACCTCAGGTGTTCTGCCTGCCTTGGCCTCCCAAAGTCCTGGGATTATAGCCGTGAGCCACCCCACCTGCTCGACAGTGTCTTCTCTAAGCAGAACTGTACCCCTGAAGCGCCCAGGCTAGAACTCTCTATTGAATGAGGATCACTCCATTGTGCCAGCTGCTCTCATATTGCTTTGATGGCCTTTCTCAGAAAGGAGAAAGGTGGTGCTGGGTGTGGCTTTGGCTTCCTATGGCCGCCCCAATGCTGGTCTGACACTTTCTGAATCTGGTTTGTGGTTGGATCTGTGCATCCTACCGCTCCACTCCATGTCCTGGCCTTGGAGAAATCATTTCCCTCCCGCCGTGATTGTTCACCTTCAAAGGTCAACAAAGGCAGTAGGCACTGCTGAGCTCTTGCAGCCTTCAGGGCTCAGCTGCTTCCTCTCCTGCTTCCAGTGAGGGGTTGCTTGAGGGTGCCTTTAGGAACGAACCTCACCCCTAATGTAACTTGAGCAGGTCTTTGCTCTAAACTCTTCGCTGGGAACATACCCTCCCGTGGGACTTGGCATGGCACCCACCTCTGCAGAGCCACCTGTGCCACAGAATAACCTCTTCTCCCTAGACACACTGTGTGTCCTTGGTTGGATTCTCTAGATGGGAGGGACCCCCTGAAGCATAACTGTGTATGTTCACATATGTGCCTTGGAAGAGTTTTATGCAGGAAAGGATTTGTAAATCAGAAAAATGAATGCTGGTATCTAATTTCCTGTCCCCGTTTTAAGTCCAGACCAAGTCACCTAACCCCTCGGGCTTGCAGCCCGCATCATCCACTGGGTGATTACCTTGAGTTATCTGGTTCAGTCCCTTTGCTGTGGGCACCCTCTTTACCTCTACAAGTAAACTGCAATTAATCTGACAGCAGGGCCAAGGCAACTGACGAGTCTTGCGTGCAAATCTTGAGATCCTTTGGCACATTATCTAATTCATTGTTTTTCTTTTCTTTTTTCTTTTCTTTTCTTTTTTTTTTAGACAGGCTGGAGTGCAGTCGCACGATCTTGGCTCACTGCAACCTCTGCCTCCTGGGTTCAAGTGATTTTTGTGCCTCTACCCTCCTGAGTAGCTGGGATTCCAGGTGTGTGCCATCACCCCCAGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTTGCCATGTAGGTCAGGCTAGTCTACAAGTCTGGCCTTAAGTGATCCACCCTCCTTGGGCAGGGTGCCACCTGCCTGAAAGAAAATGCCCACCCTAGGGAAAAAGACACACACACACACACACACACACACACACACAGAGAGAGAGAGAGAGAGAGAGAGACAGAGACCAACGTGGCCTCTCTAAATAGGTAGTGGGTTAACCTTCAGAAGCAAAGGCAGACAAAAACCACTTGTGATACCTGCTGCTGCGTAGAGCCAGCCAGCATATAGATTATGCTTTCTTCCTTCTGAAGGAAGACTCTAGGATTACAGGAGTGAGCCTGGCCCCAATTCAATTCAATCTTTATGGGCATCGAACAAGGCCATTATTTATTACCCATGCTTTACAGAAGTCAAACCCAAGTCTCAGAGAGGGAAGACATTTTTTAGTCTCACTGCGAAAGTGACAGAGCTAGAATTTAGTCTCTGTCACGCTAAATCCTGCTACATGCTCCGTCTAGTTCAGAGCCTGTCTGCAGGTCGACACTGGAGTCCCTCAGTTTTCCTCATCAGGCTCCTGGTCTGATTCTTCCAAGATCACTCTCTTTCCCTCAGCGGAAGCCAGCTGGGAATCACTGGCCTTGTAACCTCTTCAGGCGACCTCCTTGGGATGTTCACAAGGAGCATAGACATCTGGAGAATGATACTGTTTTTTCCTAGGGCTGGGATGGGGGTGGTATCCCTCACATCATTCCAGAAACAGCGCCAGCCCTGCTTTTATCAGCGGGGGCCACAAAGAGGCGACAAGCCCTGATCAAATGTGAGCGAGATTGACAATCTCAGCACTTTCCAGGGAAAGCATCCCGTCCCACATGGCTTCACGCCTCCAAGGAAGCCCCATCCTGAGACAGAGAGACCCCAAATCACAGTGTGTTTCCTTTTGGCCAGAGATGAGGCTTACTCATCTCAGACAGCTGTGTCCACGGCATGTTCCTCAAGGACAGCTGCTCCAGATGAAAAGAAGAGATGCTCCCAGAGCCTTGAGGGGCTGCTGATAGGAACCCAAGGCCTCACCCTGGGGCTGTATCCTGTGGCTTCAAAAATATATGTATTTGAAAGCTTCTAGCAAAACAGATTACACAAGAACGCAAATGTAAGATCCCTTTGGGATTCTAACTTTTTTTCTTAAGGTGTTTAAAGAAAAATGACACCCTTAAAAAGAAATGCCATTTGTTTTCAAAGCTGCAGCACCAGAGGACATGGAAGAGAAAGGCTGAAGTGTCCCTGAAAATGAGTGAAGATTCCAGTCTGTTTTTACTAATGTCCAAAATCTTAGGTTTATTGCCTTTGCGTTCCTCTGCCCCAGGGTCTCTGTGTGGCAGGCGACTGGCTCTCCTTCCATGGTGCAGTCATCGTCTGGCGGAATGCATGCTCACACACGGAAGTTGGTTGAGCCTCTCCTTTGAGCAGTCCTTCCTCTGGTGACGTGCACAGGCGCCCATCATGCCCATTTCATAGATGAGGAAACTGAGGCTGAGAGGGATGCTGCAATTTAGGACTTCTGGGTGATATCACAGAAGCCTCATTCTCTTTTGTGGCATGTACCTTCTCTATTTGGGAAGTTAAATTGGACTATGGGGATTGGACCAAGGGGTCTTCTTGCTTCCGCTTTCTCTAGGCCAAGGCTTTGCAGTTATGGAGGAAGAAAGAGCTGGGGTCTGTCTTGGCAACCCTGTGACTCTTCTCCCCTATCCTCACCTGCCTTCTCACTTGACCAACATATTTTAAGGGCTCCATGTACAAAGGTAGGGCTGTGCCCCTTTCCCAACCAGCACCTTGCCCCTGTACCCTGATATGGGATGGTTAAGGCACACAGGCTTCATGGATGGGCCCCTACGACCCCACATGGAGCAGACCTGGACAGGGTATGGTCCCCCAGGTGGAGGTGCTGGAGAAAAGCCGCGTTAGGCAGCACGGGAGCCAGGTGCGGGGTCTCTCAAAGCCTCGAGTCCCTCCCAGTGCTGTGCTCTGTGAGGACTGCTTTTGACTGCAGGGCACTGACACTCATACCTTTTGCTTCTGCAGCTCACCATACTCCCTCGAGCCTTCTCCCGACCTGCGCGGGTCACCTTCGCACATACAGCCATCATGATGGTACTTTAAGTGGAGGCTGAATCATCTCCCCTTTGAGCTGCTTGGCACGTGGCTCCCTTGGTGTTCCCCTTTTACTGCCAGGACACTGAGATTTCGAGACGTAAGTGGCTTACCTGAGGCCATGTCCTAACAGAGAAGATGAAGAGATGATTGAAACAGGCCTAAGACCAGACCTAAGGGTCTGTACATTTTCCACATACTTTCCATATCTTTAGAGGCCTGACCAAAGCAGATCTTTTCCTTTCTTCTAGGTAAGTCCAAAGGCACCTGCCTGCTGGGCCCACTGTTTTCTAACTTTCCTAACTTTCTGATCCCTTGGAGGTGATAATCAAATATTCTAGTCTGAGGCATTGGGATACATCGTGCTAGGTTCTGACACTCTGCGTCAGGCCTCAACCCTGCATTTTGTGGAGGTGGGTGGGAGAATGTTCCCCTGGGGAACATGCCTAGACACGGGGGACAACAGTTGCCCTCATGCGGAGGTACCTGTTTACTCGCTCTTATGCGACCGCTTTCACAAAACCACTGCAGGTGAGTGAGTTCCTGCTGAATATCAGCCCTGGTGTCTCTAGACTCATTATTTCCCCCACCCAACCCCTATGTTAGTTCATCTCCAGCCACATTTTTATTGCCATAATCCAGGCCTGGACAGCCCAACATCTTTTAACAATTTTAATTACTGAAAATAATAACTGCATTTTTTTTAAAGCCCAACTTTTGGTAGAGTCAGCCCAAAATACAGTCTTTGTGTTCCCATCTGGGAACTGGATTTGGAATTGTTCTTCCATGAGACTGCAGAGCAGAACCGCAGGGCCAGAGGTCCCACGAGCTGGTCACACCCGGTTCTGCTCCTTGCTGGCTGAGTGACCTTGGGCATTGTGATTCATATTCTCATCTCCCTTCAAGTGTGGTTACGAATGCTTTTTATCCTGCTTATCAATTTCTATGATTGCCATAAAATATTAACACAAATTTAGCATTTATATAACATAATATATTAATGCATAGTTTTTTTGTGGGGGGGGGCGGTGGAGGGGCAGTGTTCAGACAGAGTCTTCCTCTGTCACCCAGGCTGGAGTCCATGCTGTGATCCTGGCCCACTGAACCTTGACCTCCAGGGCTCAAGGGGTCCTCCCACCTCAGCCTCCAGAGTAGCTGGGACTTCAGGCATGAGCTATCACACCTGGCTAATTTTTTGTATTTTTTGTACAGACGAGGTCTCACTATCTTGCCCAGGCAGGCCTGGAACTCCTCGACTCAAGCGATCCTCCCACCTCGGCCTTCTAAAGTGCTGTGATTACAGGTCTGAGCCACTATGTCCGCCTCACGTCCAGTTATCTAGGGCACAGGTCAGACATGGATCTCTCCAGGCTAACATCAAGGAACCTGTAGGCTGCCTTCCATTCTGGAGACTGCAGCGGAGAGTCTGTTCCTTGCTCATTCTGGATGTTGGCAGAATTTGTTTCCTTGAGGTTCTAGGGCTGAGATCCCGTTTTCTTGCTGGCTGTCCAGATCCATTGAGCTTCTGGAAGCCTCCTCGCTACGCTTGTGGCCTCCTCTCTCCATTTTCAAGTCCAGCAATGGTGGGTCCAGTTCCTTTTAGGATTTAAATCTTTTCTCCCTCTTTCTTTTCACCTCTGTGATCTCAGCTAGAAAAGATTATCTAATTTTAAGGATTCATGTGATTGGACTGGGGCCACCCTGATAATCCAGAATAATCCCTACTTCAAGGTCCTTAGGTTTAATCACATCTAGGAAGTTCTATTGCCATGGGAGGCAACATATTCACAGGTTCCAGGAAATTCCGACATGGGCATCTCTTTGATTGGAATGAGGGGTGGCAGGTATTCTGACACAGTACCTCACAAGGGTTGCTGTGATGATGAAGTGAATGGAGACACGTAAAGCGCTTAAAATATTATGTAGAGCCATGTGAATTTGGCAGCATTGAATTGTTGACCTATAAAAGGTCAACTTAATAGTATCTGGTCTATAGTAAATCTTCAGTAAATGTTTCCTCTCATTACTCTAGTGGTAGAAATGTCATGCTTTATTTAGCCAGTTTGCTATTGTTGGGCATTACTTTTTAAAGAGTTATTATTTTGTTATTATAGTATATATGTGAACACCGTGATCATCATGCCTTTGCAAATTTTATTCTGATTTAGGGCAATGCATGTCTTTCCACGCCACACTCAGTCTCCTGCTCTGGTGCCAGTGTCTCTGTCGCCTGAGGGGCCCCTCTTTCTTGCAGAGCCCCTCATCCAGCACCAGCTCAGCTCTGCGCCATGTGTGTGGGGTGGGACTTTTCTCTTTTGGGAAGTGGGCCATGCCTCTCCTTCCTGAGACCATCCCCTTTGGCTTCCTCGGCGCCCTTGGCTCTTTGAACCAGCCTGCAGGGCACCACACCTGTGGGCCCATTTTTGTCAGGAAACGACTCCCTTCCCAAGGGCACCCTGAGTCCCACGTCCCCAGGCCCACAGATGTTGGGCCCTCAGAGTGTGATCCCATGTCCCCAGCTCTGTAACTCCCTGCATGTGGCTCTTAAGACTCACAAGCCCATGTTTGCCTTGGCCAGACACTTTCGCCTGTCAGTTCTGCCAGTTGGCAAGTGTCATCCCCACTGTGTGAATGTGGAAGGGATAATGAAGAATTTCCACGGCTTGCCTAGGGTCGTTGAGCAATGTGGAAGGGATCATGGAGAATTTCCATGGCTTGCCTAAGGTCATCAAGCTGGCATCTCAACCCAGGTTCATCTGCCTGTCATGACAGGAAAGAAATCAGGTGTGATTCTGTTCTTGTTGACCCATAGCCACCTCTCTCATTAAGGCTTCTCCTGCAGGCAACTACACAGCCAGTGGTGGGAAAGCACCTAATTTACATCTTCATGCATTGAAACTGATGTCACTCACCTCTCCCCCTTGACCTGGAAGAGCCCCTGAAGGCTGCCATAGGGCAAATGATAACCCATTCTACAGCTGCTGAAACTGAGGCCCAGGGAGTGTCCAGACCTTTCTGAGGTCCACCATGTACTCTTGACCAGGATGAGTGATAGCCACCTGGTGACAATGTTGAAGGTTCTCATTCAGTAGAGCTGGGTTCAATTCTCACTTGCCTGACCAGCTGGTGCCTCATTTTGCTCTAAGTATTGGAGCCTCCAGCTTTATTTTCTTTCAGTGGGAAAGACTGTGAGATTCAGTCCCTCCTTGAAGCTGCGCATCGACTCTCCTCTCCTGGGTACTCTTTAGGTAGTGGCTGTTCTGAAGTGGCTTTGGAAACCCTGGAATGAAACTGTCATCTCCAATGCTGAGATTTGTATAAACTGTCATTTTAACTGTGATTATTATTCCTTAGGATTTGAGAAATAAAATCTGAGGAGGGAGCAGGACCTGCCTCAGGGCCTCCTCTCCAACTTGAGTGACCCATCTTCCCAGGTCTCCTTTTGTTCTGTCTTGAGCCTCTCTCCTGAGGTCCTGAAACAAGAGAATGTGCTGTTGTAGGGGGCCTGGAAATGTCCCATGGACCATCTCGTGACTCAGTAAGATGATGTGTGTCCTCTGGGGACAGAAGGAGGTCCTGCACAGAGTGTTCCTGCCCGTTGACGCCCTCCCCAGATCCTAACGCGAAGTCTGACACATAGTAGCCTCCCGGTAATCTTAATAAGCAAAAGGACACATTTCTCAAGTGATCTTAGCACCATTTCATGCAATCAATTCCAGCCCAGCCCTTTATTCTGGCCAGCCCTGGTGGGTCCATTAGCTGCAAAAATTAGTCGTGCTCAGTTTTAATGCAAATGACTAAGTATTACTTTATTGAATTGATTAATAAAGAAGCTCTCTTTGTATGATATCAAGACCATCAAGAAATTGCAAAGACATAGGTAGGGTCTACAGCAGAGTTTCTCAGCCTTGGCGCTGTTCATATTTTGGGTCAGATGATTTGTTGTGGGGGCTGTCCTATGTATTGTAGGATGTTGCTCGGCATCTCTGGCCTCTACCCACTGGATGCCAGTAGCTCTGTCAGTCGCAACCCCAGCTTCCAGTTGGGACAACCTAAAGTGTTTCCAGACATTGCCACATGTTCTTTTGTGGTGGTGTTGGTGCTGGTCCGTACATATGTGTGTGTAAAAATCTCCCTTTGTTGAGAACCACTAATCTAGAGACCACCTAATTAGGGCTGACGTGGGCTCTTCCACAGAGCCTTCTCCTTAAAGACAGATAGGTTGATGGACACTTGGATTTAGGGAAAAGAAAACTGAGTTGAGGGTTTAAAGTGAATTTCATCCCCAATGTGGAAGATGAGCGTTCCGTTCCTGGCTGTAGGATGTGGAGCATGTTACTCCACATGTGGGAGAAAAAAATCATCCCATCTACTTCAGGACTTTTGTGTGATTAAACAGGCAACATAGTCTAGTGCTTTTCATTCCATGCGCACTCAATAAAAAATAGGCGTTATATTTATGAATAGTAACAAAAAGCCTCTTAAGGAAAATTATTTTGGGCCCTTGTTCAAGGTTCAGTTGACCATTTATTTTTAAAGAGATGGGGGTGGCCCAGGCTGGAGTAGAGTGGTGCCATCCTAGTTCACTGCATCCTCAAACTCCTGGGCTCAATCGATCCTCCTGCTTCAACATCCCAAAGTGCTAGTATTATAGGCATCAGCCATTACACCTGGCCCATTTGACTATTTTTTCTGCTTGATTGTAGAGAAGGGAATCTAAGTCATGAAGATCTAAACTATAAAACCTGCGTGGCTTAGAGGCTGAGCATGGATTGTGATTTAAGGAAGCCCCAGGTTCAATTTCTGGTTCTGCCACTTGCTAGCCATGGTGAGACCTTGCCCAGCTTTCATACTTTCAGGTTCTTTGTCTGTAAAATGGGAACAATAAGAGTACTGACCTCACCCGGCTCTTGTGCTACTGGCTGTGCTGCCTGAATGGGCCCTCCTTTATTTGAATCCCTCTCCCACAGTTGTCCCATTTTTTTTTTTTTTTAAATGGTCACCCAAGTTCCATTATGGACGATCAGGCATTCAGGGGAAGGAGGGATCCAAAGCAGAGACAAAACCAGCCAGCCAGCTCATCCCCTCTCCAGCTGATACCGAGGAGCAGGATGCCAGTGGGAAGAAGCGTGGCCATATGGCTGGCAGGATGCCTCACTGGTAACAGTCAGCCCGGCCCCTTTGAACTGGTTTTAAGACCAATTTGGTAACTTGATTTGGAAAGTGGTATCGATGACTCCGAGGGCGCAGGCTGCTCATTAGCTGCTGTCTGGGCCCGGCAAATTGGTTTAAGTGGAATGAAATTGGTTCCTTCCCTCCCCGTGCTCATGGCTGAGGTCCAGGCCCGATTGTAATGGGAACCTCTCCTGGGCAAAGGACATAGAAAAGCTTTCCGGGGAGTCTGACCCTCTTTTTTCATATCTGAATTCTACTTTCCCCTGCGGCTCAACGCAATAGCCTCATAAAACATAAAAATCAACCTGAAGTGGGTGGGGTGAGTGTGTGTGTGGGAACTTGGATCAGAGCACAATCAACAATGAACAGTGGCCGAGTGTTTTTCAAGGGCCAGTTAACCATTCCCCTGTTGAGACACTGTGCTTGATGCATTTTTTTTCTTTTCTTTCTTTCTTTTTTATTCTCCCATATTACAAACACTGCTGGGAGGAACATCCGCACATGCTTTCTTGGTCACTTATGTGAGAGCTCATCCACCATTTATACCCTGACGCGACTTCACTGCCGTCGAGGCTAAGGAACATTTTCTGTTTCATAAGACGCGATCACATTGCCCTCCAGAACAATCATGCCAGTTTACACTCCCACTCACTGTACACAAGAGCCCTGTTTTCCCCCATCTGGTCACCCACATTTGATAGGTCAGAATTTTGCTTTTTCCCAGTCTCATCCCGGTCATCCCATTTCTCGTAGTTCCCCTGATTCCCAGGGCGATCACCACCCTGCCCTCAACTGCCCCATGCTGAACGCCCTCCAAACGCAGCATGAATCCTCACAGTTCCCAGCCTCTGCCCTGACAACCTAGGAGGACACGCTGGTCTGCTCCATTGCTTATCTGAAACGATTCCCTTTCCCTCTTCCTTTTGTTGCCTTGAGTGTCAGTTTTGGACCTCCCACTGAGCAGTTTTTTCTCTCACGTAGCCATAGACAGGACTGAGTTCTTTGGAAAATAATCACATCCCACTGTTGTTCCCATTCGTTCATTTTTTCCTTCAACTAACCAACATTATTCAGCACTTTACTCACCACAGGATGTCGAACCGAAGGCCTGCCTTTTCCGACACTCACCGTCCCCAGTCAGCTCTGTGTCCTAGGGAGAGACCCATGAGCTCTCTGGGCCTCCTTTTGTTTCTCTGTAATAAAGGACTAAAGCTACCAGCCTCGCTGCGGGTTGGAAAAAAGAAAGAGTTAGTGTAACACATGTCAATGTGTACGAACGGGTTTAGAGACAGACAAAACATTGCACCAAGGCAGGGCTCGCTGGAGTGCAGACCCAGGAAAAACACTGCAGGCCAAATTGCTTCTGGTCTGTCAGGGTACCAGCCACACATCCAACGCAGGGAACTTAGGGCCATTGGCCTTTCTGCTCATGCTTACTCTCCCAAGCTTGTTGGGTTATTATCATGCACAAGCCATTCAATCCATTGTATTGGGTGCCTAATATATCAGACACTCTTAGGTCCTAGCGATGTAAGAGCAAGCAAAACAGACATGGTTCTGCCCTTGTGGGCTGTATAGTCTAGTGGAGGAAGGGGGAAGAGGTTAAGTATTTGTAGGAAGGTGAACCCCATGTTAAGAAAGCATCTTCCATCTTTCAAATGTTTCCAAGTAGCTGGTTATTCATGATAGCGAGGAAATGGTGGTCATCTCCATTGCTCTGGTAACTAGTTTGTGTCTGAGAAAGTGCTGATTTCCAAGAAAAGGAAAGAGACCACGGATGAATGATAGCAAGACTATTAAACAGGAATACAAAGAAGAGCTCACATTTATTGAGCACCTACTATATGTGCTGGACCCTCTTGTAAGAGCTTCATACAAATTAGGCAGACAGGCAATATTATTATCCCCATTTGATCTACAAGGAAACTGAGTACAAAGTGATAGCTTTTCTGCAGAGCTTGTGCACAGGGGCCAAAGTTTGGGAACAATGCCTTTCTTTAATTTGAAAGTATCTGTTGTTGGTGTCACTTGTTGGAATTCCTAGAATCCCAGAAAAGTAAGTTTAAGTTTTCTTCTGCCAGCATCCGTCAGCCTACCTTTGACCCAAGGTCACGACTCCCTCCCTCCTCCCTTCCCTTCCCTGCTCTGACATTCTTACCTTGTTTTTGACTTCCTTATTCCCTAGCTTCCTCCAAGCAGCAGGCTCTGGGAACAGTCCCGTTCATTTATATAACAAATATTTATTGAAATGCAGACTTGTTGTTTTCATAATACCTGTGTACAAGTTAAACCCGTGGTCACTTGTTCATGTGCCTCTTGTTTATGACAAGAGGTGGTCCCTTGTTGAAAGCCTGTCACATGCCAGGTACTCAGTCTTTTCTTTCCTTCTAATAAGTAGGTGAGTATTTTCCTTCCTTTGCACACGAGGAAATGGAGGCTCAGAGAGCTTAGGTAGCTTACTCAAAGCCACACAGCTGGGTTAAATGGGTTCAGCACCATGAAAATCTGACCTTTAATGTCTGCACTCTTATTCTCTGGCTTATTGGGAAAGAATTGGACAGGGATGGTAAATGGAGTTGATGGAGGCAAAGAGATAATTACTGTTGCTCAAAGGTGGATCGAGAGAGTTTGGGCAAAAACGGAACCACGAACAAGCCGTTGAAAGTCCCCTCATCCTGGACCTGTGGTCTGTCCTTTGTAACTGCTCTTTTTTTGGCATTCCCTCTGTCTCCTCTGCCCATCCCAATGCCAGGCACACTCAGCCTGTAGGGATTTACAAGGTGGGCCTCAGGTTTCTCCCCTCCCAGGTGGGCATAGGAATCACTGCTTAGCTTAGATTTGGCAGAATGAAAGAGTCAGGCAGAGTCTCACCCGGCCCTGTTTCTTAGCTGCTTTGACACCTGGGGCAGGTTTTTGGACCTCTCTGGACATGGCCACCTGTGTTGTCACTGCCCACCACAGGCTGGGTCTGTGAATGGAAGACTGAAGAAAAGGCGATGATCACAGTCCAGGGACAAGGTTTCTGAATCTTGTGAAATAGTTACAAATACTATGAAACAGGAATACAAAGAAAAGCTCACATTTATTAAGCACTTACTTTGTGCTATACCCTCTTGTAAGAGCCTTGTACAAATTAGGCAGACAGACAATATTATTATCCCCATTTTACCTATAAGGAAACTGAGTGCAAAGTGACAGCTTTTCTGCAGAGCCTGTGCACAGGGGTCAAAGTTTGGGAACACATTGCCTTTCTTTAATCTGAAACTATCTGCTGTTGGTCTCATTTGTTGAAATTCCTAGAATCCCAGAGAAGTAAGTTTTAGCTTTCTTCTGCCAGCCCCGGTCAGCCTGCCTTTGACCCAAGGCCATAGTAAGTTCCAGAGTGACTTCCCGTCTGTTTTATTATCCCTGACAAAGGGATACAGTATTGTGCGGTGGCTGTGCATGGCGTGTAGTAGTGTTTTCCTTCTCTTCAAAAGCAGCTGCTGAGTGGTGGAGCACAGAGGTATTCCCTGAGCCCCACCTTGTGCCCATGGTAGGTCCAGGGCGTTTGGGGGAAGGAGACCGACTCTAGGTGGTCCCGTCTGGTTTCTCAGGGGAGAAAATTCATAGATCCATCTCCTAGCTGTCATCCAATTCTGTGTAGAAGGCGAAAGCCAAGGTTGCCCTCAGATTTTGATCTTGGTTCACTCTGATTTCTCTATGCCACACTAGTAGAGCTTCAGGGAAGCTTGGTGACTATGACTGGATGAATTCTGTCCCCCTTAAAACCATAGGTTGAAGTCCTACTCACCCATACCTCAGAACGTCACTGTGTTCGGAAATAGGGTCTCTAGAGAGGTACAGTTAACTGAGCTCACGTCGCGGGCCTCCAATATGGTCAGACTGGTGCCTGTCCTTATCAGAAGAAGAGATTAAGATGACAAAGGAGCAGTCAAGACCACGTGTACACACAGGGAGGAGGTGCCCATCTACAAGCCCAGGACAGAGGCCTCAGAAGAAACAACTCTGACCACACCTTGATCCTGGACTTCTGGCTTTCAGAATTGTGAGGAAATAAACCTCTGTTGTCTGAGCAACCCAGCCTGTGAAAATTTGTTGTAGCAGCCCTGGCCGATCAATACAGTGACCATGAGCAAGTCACTCACCCTCTCTGAACCCCCTTGGTCTCAGCTCTAAAAAGAAGCCTGAGAATTTCTGCCTCACAGGCTGTGGTAAGAGGCATCAGAAATAGCCGACTTTCATCGGAGGCTCACTGCGAGCCAGGGCCTGTTTAAGCCTTTTCCATGTCTGAACACACTTCATCTTCATGTGTAGCCTTTGGCTGGGCAGGGCAGATACTATTGTTCCCATTTTACACGTGACCAGAGTGGAGCACAGAGCTGTTAATTAACCTGTCCCATGTTAGTCAGCAAGGAAGGGGCTGGTCCATATGTGGAACTTCGTAGTTGTACTCTGGTGCCCACACACCAGATCACTATGCCGTCCCAGCTGTTGTTACAATAAGACTATGTAGGTGAAGGGCCCACCCAGTAGTGCCTGGCCTATGGGACACATTGAAGACCAGCCCCCTGTGACCAGAACCTCCCATTTGCTGCATTGAGTTTGGAATGTTTGAACTCCAGGAGCTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTATCTGTCTGTCTCCCTCTCTCTCCTCTCTCCCCTACCTTCCTTTTCTTCCCTCCTGTTTTTGGGAGGGAGCTCAGCTTCCCTTCACTGCCACTGCCCATCAGCATCCTCTCCCTATTCAGCCACCCCCACCCCCCATCCCTGGTATTAATTGACTTTGGCTCCTGTCCTGGAGCTCAGCCTGGCACCCAGACCTGCCGTGCTATACTAACACCTCTCACATGGTTAAACCAATGGGGGTGGCATTTAGCAGATGACGCTGAAACCCGTGAATCTGCCCTTTCTCACTGGGCCCTCACTGCTCTAGAGTCCCCGCCTCTTTTACGAAGCGGCTGTCATGGTTGATGGGTGAGTGTCAGGCCCCACCCAGGGACAGGGAGGCCCAGTGCCGGCTGTGGAGTTACCCAGACCTTACGGTAAAAACGCATCACCCTGAATGGGGGCCAGGCCAGGCATCGGCCCAAGCCGGCCCTGCCCAGCGGCTGGATTCTGACTCGCTCTGCCTTAGTCACAGCCCAGAGACTCTTCTGCTTCCAGCTGAGGCTGTCCCCTGCCTTCCCTGGCGGCCCGGGTTCCTGGAAAAGCTGTGTGCCAGAGGACGGGAGTTTCCCTCCAACTTAAGCCATTAGAAAGCTCATTTATTGAGCACTTACTAAGTGTCAGAGACTGTGCTAGGCACTTTACATGAATCTTCTCATTTAATCCTTTTAATAAACTTCCGGGGCACATGCTCTTCTAATCTCCCTTTTACTGATGATGCAGGCTTCACAGTGGGAATGCTAACCGCAGAAAGCAGCTCACCTCACTTGGGTGCTACTGTGTGCCAAGTCCTGGGGTTAGCACCCAATAGCCCCGTGGCGGCATGCTGTTATTACTCTCCCTGCATAGGAGTGGGAGGCTGAGACCTGGGTGTTTCTGGGTGTCCCAGCTCCTGTATGCCATCTGCCTGTCCAGCCCTTAGCCACAAAGCTGTTGTGCCATGTGGGGAGATGCGGCCAGTTTCCCAGGTGAGGCTGGTCCTGCTTCAAGCG Human PVT1 Transcript (SEQ ID NO: 31)AGCACATGGCCCCGCSGGCCGGCCGGGCTCGGGGCGGCCGGGACGACGAGGGGCGACCACGAGCTGCGAGCAAAGATGTGCCCCGGGACCCCCGGCACCTTCCACTGGATTTCCTTGCGGAAAGGATGTTGGCGGTCCCTGTGACCTGTGGAGACACCGCCAGATCTGCCCTCCACAGGCCTGATCTTTTCGCCAGAAGGAGATTAAAAACATGCCCCTCAACATGCCTGTGCCTGTCAGCTGCATGGAGCTTCGTTCAAGTATTTTCTGAGCCTGATGGATTTACACTGATCTTCAGTGGTCTGGGGAATAACGCTGGTGGAACCATGCACTGGAATGACACACGCCCGGCACATTTCAGGATACTAAAAGTGGTTTTAAGGGAGGCTGTGGCTGAATGCCTCATGGATTCTTACAGCTTGGATGTCCATGGGGGACGAAGGACTCCAGCTCCCTGACACCGTTGAGATCTCTGTTTACTTAGATCTCTCCCAACTTCCTTTCGCTCTCCCTATCGAATGTAAGACCCCGACTCTTCCTGGTGAAGCATCTGATGCACGTTCCATCCGGCGCTCAGCTGGGCTTGAGCTGACCATACTCCCTGGAGCCTTCTCCCGAGGTGCGCGGGTGACCTTGGCACATACAGCCATCATGATGGTACTTTAAGTGGAGGCTGAATCATCTCCCCTTTGAGCTGCTTGGCACGTGGCTCCCTTGGTGTTCCCCTTTTACTGCCAGGACACTGAGATTTGGAGAGGTAAGTGGCTTACCTGAGGCCATGTGCTAACAGAGAAGATGAAGAGATGATTGAAACAGGCCTAAGACCAGACCTAAGGGTCTGTACATTTTCCACATACTTTCCATATCTTTAGAGGCCTGACCAAAGCAGATCTTTTCCTTTCTTCTAGGTAAGTCCAAAGGCACCTGCCTGCTGGGCCCACTGTTTTCTAACTTTCCTAACTTTCTGATCCCTTGGAGGTGATAATCAAATATTCTAGTCTGAGGCATTGGGATACATGGTGCTAGGTTCTGAGACTCTGCGTCAGGCCTGAACCCTGCATTTTGTGGAGGTGGGTGGGAGAATGTTCCCCTGGGGAACATGCCTAGACACGGGGGACAACAGTTGCCCTCATGGGGAGGTACCTGTTTACTCGCTGTTATGGGACCGCTTTCACAAAACCACTGCAGGTGAGTGAGTTCCTGCTGAATATCAGGCCTGGTGTCTCTAGACTCATTATTTCCCCCACCCAACCCCTATGTTAGTTCATCTCGAGCCACATTTTTATTGCCATAATCCAGGCCTGGACAGGCCAAGATCTTTTAACAATTTTAATTACTGAAAATAATAACTGCATTTTTTTTAAAGCCCAACTTTTGGTAGAGTCAGCCCAAAATACAGTCTTTGTGTTGCCATCTGGGAACTGGATTTGGAATTGTTCTTCCATGAGACTGCAGAGCAGAACGGCAGGGCCAGAGGTCCCACGAGCTGGTCAGACCCGGTTCTGCTCCTTGCTGGCTGAGTGACCTTGGGCATTGT Human PVT1 Protein (SEQ ID NO: 33)MGPRAGRARGGRDEEGRRRAASKDVPRDPRHLPVDFLAERMLAVPVTCGDTARSALHRPDLLARRRLKRCPSRWLCLSAAWSFVQVFSEPDGFTVIFSGLGNNAGGTMHWNDTRPAHFRILKVVLREAVAECLMDSYSLDVHGGRRTAAG

[0336] Certain aspects of the present invention are described in greaterdetail in the non-limiting examples that follow.

EXAMPLES

[0337] The following examples are put forth so as to provide those ofordinary skill in the art with a complete disclosure and description ofhow to make and use the present invention, and are not intended to limitthe scope of what the inventors regard as their invention nor are theyintended to represent that the experiments below are all and onlyexperiments performed. Efforts have been made to ensure accuracy withrespect to numbers used (e.g. amounts, temperature, etc.) but someexperimental errors and deviations should be accounted for. Unlessindicated otherwise, parts are parts by weight, molecular weight isweight average molecular weight, temperature is in degrees Celsius, andpressure is at or near atmospheric.

Example 1 Insertion Site Analysis Following Tumor Induction in Mice

[0338] Tumors are induced in mice using either mouse mammary tumor virus(MMTV) or munine leukemia virus (MLV). MMTV causes mammaryadenocarcinomas and MLV causes a variety of different hematopoeticmalignancies (primarily T- or B-cell lymphomas). Three routes ofinfection are used: (1) injection of neonates with purified viruspreparations, (2) infection by milk-borne virus during nursing, and (3)genetic transmission of pathogenic proviruses via the germ-line (Akvr1and/or Mtv2). The type of malignancy present in each affected mouse isdetermined by histological analysis of H&E-stained thin sections offormalin-fixed, paraffin-embedded biopsy samples. Host DNA sequencesflanking all clonally-integrated proviruses in each tumor are recoveredby nested anchored-PCR using two virus-specific primers and two primersspecific for a 40 bp double stranded DNA anchor ligated to restrictionenzyme digested tumor DNA. Amplified bands representing host/virusjunction fragments are cloned and sequenced. Then the host sequences(called “tags”) are used to BLAST analyze the Celera mouse genomicsequence. For each individual tag, three parameters are recorded: (1)the mouse chromosome assignment, (2) base pair coordinates at which theintegration occurred, and (3) provirus orientation. Using thisinformation, all available tags from all analyzed tumors are mapped tothe mouse genome. To identify the protooncogene targets of provirusinsertion mutation, the provirus integration pattern at each cluster ofintegrants is analyzed relative to the locations of all known genes inthe transcriptome. The presence of provirus at the same locus in two ormore independent tumors is prima facie evidence that a protooncogene ispresent at or very near the proviral integration sites. This is becausethe genome is too large for random integrations to result in observableclustering. Any clustering that is detected is unequivocal evidence forbiological selection during tumorigenesis. In order to identify thehuman orthologs of the protooncogene targets of provirus insertionmutation, a comparative analysis of syntenic regions of the mouse andhuman genomes is performed.

[0339] An example of PCR amplification of host/virus junction fragmentsis presented in FIG. 1. Lane 1 contains the amplification products fromnormal control DNA and lane 2 contains the amplification products fromtumor DNA. The bands result from 5′ host/virus junction fragmentspresent in the DNA samples. Lane 1 has bands from the env/3′ LTRjunctions from all proviruses (upper) and the host/5′ LTR from thepathogenic endogenous Mtv2 provirus present in this particular mousestrain. This endogenous provirus is detected because its sequence isidentical to the new clonally integrated proviruses in the tumor. Allfour new clonally integrated proviruses known to be in this tumor arereadily detected.

Example 2 Analysis of Quantitative RT-PCR: Comparative C_(T) Method

[0340] The expression level of target genes is quantified using the ABIPRISM 7900HT Sequence Detection System (Applied Biosystems, California).The method is based on the quantitation of the initial copy number oftarget template in comparison to that of a reference (normalizer)housekeeper gene (Pre-Developed TaqMan® Assay Reagents Gene ExpressionQuantification Protocol, Applied Biosystems, 2001). Accumulation of DNAproduct with each PCR cycle is related to amplicon efficiency and theinitial template concentration. Therefore the amplification efficiencyof both the target and the normalizer must be approximately equal. Thethreshold cycle (C_(T)), which is dependent on the starting templatecopy number and the DNA amplification efficiency, is a PCR cycle duringwhich PCR product growth is exponential. With a similar dynamic rangefor the target and normalizer, the comparative C_(T) method isapplicable.

[0341] An example of the comparative C_(T) method of gene expression forquantitative RT-PCR is shown in FIG. 2. In the first step, assays areperformed in quadruplicate on a normal tissue and several sampletissues. In these tissues, the means and standard deviations of C_(T)values are determined for housekeeper genes (chosen as controls if shownto be biologically stable among various samples, irrespective of diseasestate) and for the target gene. FIG. 2 shows an example of average C_(T)values for a housekeeper gene and target gene. These values can fallwithin a range from upper teens to 40 depending on the intrinsicexpression level of the gene in the particular tissue. The coefficientof variance of all replicate sets cannot exceed 1.5%.

[0342] An assessment of how the ΔC_(T) changes with template dilutionverifies that the efficiencies of the target and housekeeper ampliconsare approximately equal if the log input amount of template RNA versusΔC_(T) plot has a slope <0.10. With the relative efficiencies verifiedfor target and housekeeper, the ΔΔC_(T) comparative calculation becomesvalid, as mentioned above. An example of the calculated differencebetween the C_(T) values of target and housekeeper genes (ΔC_(T)) forvarious samples is shown in FIG. 3. The ΔΔC_(T) is calculated for eachsample by subtracting its ΔC_(T) value from the ΔC_(T) value of thebaseline (calibrator) sample. If the expression is increased in somesamples and decreased in others, ΔΔC_(T) will be a mixture of negativeand positive values. The final step in the calculation is to transformthese values to absolute values. The formula for this is:

Comparative expression level=2^(−ΔΔCT)

[0343] The final value for the calibrator should always be one. FIG. 4shows the ΔΔC_(T) and comparative expression level for each sample fromFIG. 3.

Example 3 Analysis of mRNA Expression of Various Genes in Cancer Samples

[0344] mRNA was prepared from various cancer samples as by standardprocedures as are known in the art. Gene expression was measured asdescribed in Example 2 above and as further described below. The5′-nuclease (TaqMan) chemistry differs from standard PCR by the additionof a dual-labeled (reporter and quencher) fluorescent probe whichanneals between the two PCR primers. The fluorescence of the reporterdye is quenched by the quencher being in close proximity. During thermalcycling, the 5′ nuclease activity of Taq DNA polymerase cleaves theannealed probe and liberates the reporter and quencher dyes. An increasein fluorescence is seen, and the cycle number in which the fluorescenceincreases above background is related to the starting templateconcentration in a log-linear fashion.

[0345] For data analysis, expression level of the target gene wasnormalized with the expression level of a house keeping gene. The meanlevel of expression of the housekeeping gene was subtracted from themean expression level of the target gene. Standard deviation was thendetermined. In addition, the expression level of the target gene incancer tissue is compared with the expression level of the target genein normal tissue. In FIGS. 5-24, bars represent the mean of expressionlevel and error bars represent standard deviation.

[0346] (i) SNL1

[0347]FIG. 5 depicts mRNA expression of SNL1 in breast cancer tissuecompared with expression in normal tissue. Samples 1-50 are breastcancer samples. Samples 51 and 52 are normal tissues. SNL1 wasup-regulated in approximately 20% of breast cancer samples examined.

[0348] (ii) FOSB

[0349]FIG. 6 depicts mRNA expression of FOSB in colon cancer tissuecompared with expression in normal tissue. Samples 1-11 are normalsamples. Samples 12-31 are colon cancer tissues.

[0350]FIG. 7 depicts mRNA expression of FOSB in lung cancer tissuecompared with expression in normal tissue. Samples 1-9 are normalsamples. Samples 10-43 are lung cancer tissues.

[0351]FIG. 8 depicts mRNA expression of FOSB in pancreas cancer tissuecompared with expression in normal tissue. Samples 1-10 are normalsamples. Samples 11-31 are pancreas cancer tissues.

[0352]FIG. 9 depicts mRNA expression of FOSB in ovary cancer tissuecompared with expression in normal tissue. Samples 1-16 are normalsamples. Samples 17-44-are ovary cancer tissues.

[0353]FIG. 10 depicts mRNA expression of FOSB in stomach cancer tissuecompared with expression in normal tissue. Samples 1-10 are normalsamples. Samples 11-39 are stomach cancer tissues.

[0354]FIG. 11 depicts mRNA expression of FOSB in breast cancer tissuecompared with expression in normal tissue. Samples 1-9 are normalsamples. Samples 10-30 are breast cancer tissues. FOSB was up-regulatedin approximately 26% of breast cancer samples examined.

[0355]FIG. 12 depicts mRNA expression of FOSB in prostate cancer tissuecompared with expression in normal tissue. Samples 1-7 are normalsamples. Samples 8-37 are prostate cancer tissues.

[0356] (iii) MYC

[0357]FIG. 13 depicts mRNA expression of MYC in breast cancer tissuecompared with expression in normal tissue. Samples 1-50 are breastcancer samples. MYC was up-regulated in approximately 8% of breastcancer samples examined.

[0358]FIG. 14 depicts DNA amplification of MYC in breast cancer tissuecompared with expression in normal tissue. Samples 1-49 are breastcancer samples. MYC DNA was amplified in approximately 21% of breastcancer samples examined.

[0359] (iv) CCND1

[0360]FIG. 15 depicts mRNA expression of CCND1 in breast cancer tissuecompared with expression in normal tissue. Samples 1-50 are breastcancer samples. Samples 51 and 52 are normal tissues. CCND1 wasup-regulated in approximately 26% of breast cancer samples examined.

[0361]FIG. 16 depicts mRNA expression of CCND1 in colon cancer (sigmoid)tissue compared with expression in normal tissue. Samples 1-12 arenormal samples. Samples 13-29 are colon cancer tissues.

[0362]FIG. 17 depicts mRNA expression of CCND1 in colon cancer(transverse) tissue compared with expression in normal tissue. Samples1-12 are normal samples. Samples 13-30 are colon cancer tissues.

[0363]FIG. 18 depicts mRNA expression of CCND1 in lung tissue comparedwith expression in normal tissue. Samples 1-9 are normal samples.Samples 10-43 are lung cancer tissues.

[0364]FIG. 19 depicts mRNA expression of CCND1 in ovary tissue comparedwith expression in normal tissue. Samples 1-14 are normal samples.Samples 15-41 are ovary cancer tissues.

[0365] (v) NFKB1

[0366]FIG. 20 depicts mRNA expression of NFKB1 in breast cancer tissuecompared with expression in normal tissue. Samples 1-50 are breastcancer samples. Samples 51 and 52 are normal tissues. NFKB1 wasup-regulated in approximately 25% of breast cancer samples examined.

[0367]FIG. 21 depicts mRNA expression of NFKB1 in lung tissue comparedwith expression in normal tissue. Samples 1-9 are normal samples.Samples 10-44 are lung cancer tissues.

[0368]FIG. 22 depicts mRNA expression of NFKB1 in skin tissue comparedwith expression in normal tissue. Samples 1-9 are normal samples.Samples 10-46 are skin cancer tissues.

[0369] (vi) PVT1

[0370]FIG. 23 depicts mRNA expression of PVT1 in breast cancer tissuecompared with expression in normal tissue. Samples 1-50 are breastcancer samples. PVT1 was up-regulated in approximately 10% of breastcancer samples examined.

[0371]FIG. 24 depicts DNA amplification of PVT1 in breast cancer tissuecompared with expression in normal tissue. Samples 1-50 are breastcancer samples.

Example 4 Detection of Elevated Levels of cDNA Associated with CancerUsing Arrays

[0372] cDNA sequences representing a variety of candidate CA genes to bescreened for differential expression in cancer are assayed byhybridization on polynucleotide arrays. The cDNA sequences include cDNAclones isolated from cell lines or tissues of interest. The cDNAsequences analyzed also include polynucleotides comprising sequenceoverlap with sequences in the Unigene database, and which encode avariety of gene products of various origins, functionality, and levelsof characterization. cDNAs are spotted onto reflective slides (Amersham)according to methods well known in the art at a density of 9,216 spotsper slide representing 4,068 sequences (including controls) spotted induplicate, with approximately 0.8 μl of an approximately 200 ng/μlsolution of cDNA.

[0373] PCR products of selected cDNA clones corresponding to the geneproducts of interest are prepared in a 50% DMSO solution. These PCRproducts are spotted onto Amersham aluminum microarray slides at adensity of 9216 clones per array using a Molecular Dynamics GenerationIII spotting robot. Clones are spotted in duplicate, for a total of 4608different sequences per chip.

[0374] cDNA probes are prepared from total RNA obtained by laser capturemicrodissection (LCM, Arcturus Enginering Inc., Mountain View, Calif.)of tumor tissue samples and normal tissue samples isolated frompatients.

[0375] Total RNA is first reverse transcribed into cDNA using a primercontaining a T7 RNA polymerase promoter, followed by second strand DNAsynthesis. cDNA is then transcribed in vitro to produce antisense RNAusing the T7 promoter-mediated expression (see, e.g., Luo et al (1999)Nature Med 5:117-122), and the antisense RNA is then converted intocDNA. The second set of cDNAs are again transcribed in vitro, using theT7 promoter, to provide antisense RNA. This antisense RNA is thenfluorescently labeled, or the RNA is again converted into cDNA, allowingfor a third round of T7-mediated amplification to produce more antisenseRNA. Thus the procedure provides for two or three rounds of in vitrotranscription to produce the final RNA used for fluorescent labeling.Probes are labeled by making fluorescently labeled cDNA from the RNAstarting material. Fluorescently labeled cDNAs prepared from the tumorRNA sample are compared to fluorescently labeled cDNAs prepared fromnormal cell RNA sample. For example, the cDNA probes from the normalcells are labeled with Cy3 fluorescent dye (green) and the cDNA probesprepared from suspected cancer cells are labeled with Cy5 fluorescentdye (red).

[0376] The differential expression assay is performed by mixing equalamounts of probes from tumor cells and normal cells of the same patient.The arrays are prehybridized by incubation for about 2 hrs at 60° C. in5×SSC, 0.2% SDS, 1 mM EDTA, and then washing three times in water andtwice in isopropanol. Following prehybridization of the array, the probemixture is then hybridized to the array under conditions of highstringency (overnight at 42° C. in 50% formamide, 5×SSC, and 0.2% SDS.After hybridization, the array is washed at 55° C. three times asfollows: 1) first wash in 1×SSC/0.2% SDS; 2) second wash in 0.1×SSC/0.2%SDS; and 3) third wash in 0.1×SSC.

[0377] The arrays are then scanned for green and red fluorescence usinga Molecular Dynamics Generation III dual color laser-scanner/detector.The images are processed using BioDiscovery Autogene software, and thedata from each scan set normalized. The experiment is repeated, thistime labeling the two probes with the opposite color in order to performthe assay in both “color directions.” Each experiment is sometimesrepeated with two more slides (one in each color direction). The datafrom each scan is normalized, and the level of fluorescence for eachsequence on the array expressed as a ratio of the geometric mean of 8replicate spots/genes from the four arrays or 4 replicate spots/genefrom 2 arrays or some other permutation.

[0378] Normalization: The objective of normalization is to generate acDNA library in which all transcripts expressed in a particular celltype or tissue are equally represented (S. M. Weissman, Mol Biol. Med.4(3):133-143 (1987); Patanjali, et al., Proc. Natl. Acad. Sci. USA88(5):1943-1947 (1991)), and therefore isolation of as few as 30,000recombinant clones in an optimally normalized library may represent theentire gene expression repertoire of a cell, estimated to number 10,000per cell.

[0379] Total RNA is extracted from harvested cells using RNeasy™ ProtectKit (Qiagen, Valencia, Calif.), following manufacturer's recommendedprocedures. RNA is quantified using RiboGreen™ RNA quantification kit(Molecular Probes, Inc. Eugene, Oreg.). One fig of total RNA is reversetranscribed and PCR amplified using SMART™ PCR cDNA synthesis kit(ClonTech, Palo Alto, Calif.). The cDNA products are size-selected byagarose gel electrophoresis using standard procedures (Sambrook, J. T.,et al. Molecular Cloning: A Laboratory Manual, 2d ed., Cold SpringHarbor Laboratory Press, NY). The cDNA is extracted using Bio 101Geneclean® II kit (Qbiogene, Carlsbad, Calif.). Normalization of thecDNA is carried out using kinetics of hybridization principles: 1.0 μgof cDNA is denatured by heat at 100° C. for 10 minutes, then incubatedat 42° C. for 42 hours in the presence of 120 mM NaCl, 10 mM Tris.HCl(pH=8.0), 5 mM EDTA.Na+ and 50% formamide. Single-stranded cDNA(“normalized”) is purified by hydroxyapatite chromatography (#130-0520,BioRad, Hercules, Calif.) following the manufacturer's recommendedprocedures, amplified and converted to double-stranded cDNA by threecycles of PCR amplification, and cloned into plasmid vectors usingstandard procedures (Sambrook, J. T., et al. Molecular Cloning: ALaboratory Manual, 2d ed., Cold Spring Harbor Laboratory Press, NY). Allprimers/adaptors used in the normalization and cloning process areprovided by the manufacturer in the SMART™ PCR cDNA synthesis kit(ClonTech, Palo Alto, Calif.). Supercompetent cells (XL-2 BlueUltracompetent Cells, Stratagene, California) are transfected with thenormalized cDNA libraries, plated on solid media and grown overnight at36° C.

[0380] The sequences of 10,000 recombinants per normalized library areanalyzed by capillary sequencing using the ABI PRISM 3700 DNA Analyzer(Applied Biosystems, California). To determine the representation oftranscripts in a library, BLAST analysis is performed on the clonesequences to assign transcript identity to each isolated clone, i.e.,the sequences of the isolated polynucleotides are first masked toeliminate low complexity sequences using the XBLAST masking program(Claverie “Effective Large-Scale Sequence Similarity Searches,” ComputerMethods for Macromolecular Sequence Analysis, Doolittle, ed., Meth.Enzymol. 266:212-227 Academic Press, NY, N.Y. (1996); see particularlyClayerie, in “Automated DNA Sequencing and Analysis Techniques” Adams etal., eds., Chap. 36, p. 267 Academic Press, San Diego, 1994 and Clayerieet al. Comput. Chem. (1993) 17:191). Generally, masking does notinfluence the final search results, except to eliminate sequences ofrelative little interest due to their low complexity, and to eliminatemultiple “hits” based on similarity to repetitive regions common tomultiple sequences, e.g., Alu repeats. The remaining sequences are thenused in a BLASTN vs. GenBank search. The sequences are also used asquery sequence in a BLASTX vs. NRP (non-redundant proteins) databasesearch.

[0381] Automated sequencing reactions are performed using a Perkin-ElmerPRISM Dye Terminator Cycle Sequencing Ready Reaction Kit containingAmpliTaq DNA Polymerase, FS, according to the manufacturer's directions.The reactions are cycled on a GeneAmp PCR System 9600 as permanufacturer's instructions, except that they are annealed at 20° C. or30° C. for one minute. Sequencing reactions are ethanol precipitated,pellets are resuspended in 8 microliters of loading buffer, 1.5microliters is loaded on a sequencing gel, and the data is collected byan ABI PRISM 3700 DNA Sequencer. (Applied Biosystems, Foster City,Calif.).

[0382] The number of times a sequence is represented in a library isdetermined by performing sequence identity analysis on the cloned cDNAsequences and assigning transcript identity to each isolated clone.First, each sequence is checked to determine if it is a bacterial,ribosomal, or mitochondrial contaminant. Such sequences are excludedfrom the subsequent analysis. Second, sequence artifacts, such as vectorand repetitive elements, are masked and/or removed from each sequence.

[0383] The remaining sequences are compared via BLAST (Altschul et. al,J. Mol. Biol., 215:40, 1990) to GenBank and EST databases for geneidentification and are compared with each other via FastA (Pearson &Lipman, PNAS, 85:2444, 1988) to calculate the frequency of cDNAappearance in the normalized cDNA library. The sequences are alsosearched against the GenBank and GeneSeq nucleotide databases using theBLASTN program (BLASTN 1.3MP: Altschul et al., J. Mol. Bio. 215:403,1990). Fourth, the sequences are analyzed against a non-redundantprotein (NRP) database with the BLASTX program (BLASTX 1.3MP: Altschulet al., supra). This protein database is a combination of theSwiss-Prot, PIR, and NCBI GenPept protein databases. The BLASTX programis run using the default BLOSUM-62 substitution matrix with the filterparameter: “xnu+seg”. The score cutoff utilized is 75. Assembly ofoverlapping clones into contigs is done using the program Sequencher(Gene Codes Corp.; Ann Arbor, Mich.). The assembled contigs are analyzedusing the programs in the GCG package (Genetic. Computer Group,University Research Park, 575 Science Drive, Madison, Wis. 53711) SuiteVersion 10.1.

Example 5 Detection of CA-Sequences in Human Cancer Cells and Tissues

[0384] DNA from prostate and breast cancer tissues and other humancancer tissues, human colon, normal human tissues includingnon-cancerous prostate, and from other human cell lines are extractedfollowing the procedure of Delli Bovi et al. (1986, Cancer Res.46:6333-6338). The DNA is resuspended in a solution containing 0.05 MTris HCl buffer, pH 7.8, and 0.1 mM EDTA, and the amount of DNArecovered is determined by microfluorometry using Hoechst 33258 dye.Cesarone, C., et al., Anal Biochem 100:188-197 (1979).

[0385] Polymerase chain reaction (PCR) is performed using Taq polymerasefollowing the conditions recommended by the manufacturer (Perkin ElmerCetus) with regard to buffer, Mg²⁺, and nucleotide concentrations.Thermocycling is performed in a DNA cycler by denaturation at 94° C. for3 min. followed by either 35 or 50 cycles of 94° C. for 1.5 min., 50° C.for 2 min. and 72° C. for 3 min. The ability of the PCR to amplify theselected regions of the CA gene is tested by using a cloned CApolynucleotide(s) as a positive template(s). Optimal Mg²⁺, primerconcentrations and requirements for the different cycling temperaturesare determined with these templates. The master mix recommended by themanufacturer is used. To detect possible contamination of the master mixcomponents, reactions without template are routinely tested.

[0386] Southern blotting and hybridization are performed as described bySouthern, E. M., (J. Mol. Biol. 98:503-517, 1975), using the clonedsequences labeled by the random primer procedure (Feinberg, A. P., etal., 1983, Anal. Biochem. 132:6-13). Prehybridization and hybridizationare performed in a solution containing 6×SSPE, 5% Denhardt's, 0.5% SDS,50% formamide, 100 μg/ml denaturated salmon testis DNA, incubated for 18hrs at 420 C., followed by washings with 2×SSC and 0.5% SDS at roomtemperature and at 37° C. and finally in 0.1×SSC with 0.5% SDS at 68° C.for 30 min (Sambrook et al., 1989, in “Molecular Cloning: A LaboratoryManual”, Cold Spring Harbor Lab. Press). For paraffin-embedded tissuesections the conditions described by Wright and Manos (1990, in “PCRProtocols”, Innis et al., eds., Academic Press, pp. 153-158) arefollowed using primers designed to detect a 250 bp sequence.

Example 6 Detection of CA Sequences in Human Cancer Cells and Tissues

[0387] DNA from human cancer tissues, normal human tissues and fromother human cell lines is extracted following the procedure of DelliBovi et al. (1986, Cancer Res. 46:6333-6338). The DNA is resuspended ina solution containing 0.05 M Tris HCl buffer, pH 7.8, and 0.1 mM EDTA,and the amount of DNA recovered is determined by microfluorometry usingHoechst 33258 dye. Cesarone, C. et al., Anal Biochem 100:188-197 (1979).

[0388] Polymerase chain reaction (PCR) is performed using Taq polymerasefollowing the conditions recommended by the manufacturer (Perkin ElmerCetus) with regard to buffer, Mg²⁺, and nucleotide concentrations.Thermocycling is performed in a DNA cycler by denaturation at 94° C. for3 min. followed by either 35 or 50 cycles of 94° C. for 1.5 min., 50° C.for 2 min. and 72° C. for 3 min. The ability of the PCR to amplify theselected regions of CA genes is tested by using a cloned CApolynucleotide(s) as a positive template(s). Optimal Mg²⁺, primerconcentrations and requirements for the different cycling temperaturesare determined with these templates. The master mix recommended by themanufacturer is used. To detect possible contamination of the master mixcomponents, reactions without template are routinely tested.

[0389] Southern blotting and hybridization are performed as described bySouthern, E. M., (J. Mol. Biol. 98:503-517, 1975), using the clonedsequences labeled by the random primer procedure (Feinberg, A. P., etal., 1983, Anal. Biochem. 132:6-13). Prehybridization and hybridizationare performed in a solution containing 6×SSPE, 5% Denhardt's, 0.5% SDS,50% formamide, 100 μg/ml denaturated salmon testis DNA, incubated for 18hrs at 42° C., followed by washings with 2×SSC and 0.5% SDS at roomtemperature and at 37° C. and finally in 0.1×SSC with 0.5% SDS at 68° C.for 30 min (Sambrook et al., 1989, in “Molecular Cloning: A LaboratoryManual”, Cold Spring Harbor Lab. Press). For paraffin-embedded tissuesections the conditions described by Wright and Manos (1990, in “PCRProtocols”, Innis et al., eds., Academic Press, pp. 153-158) arefollowed using primers designed to detect a 250 bp sequence.

Example 7 Expression of Cloned Polynucleotides in Host Cells

[0390] To study the protein products of CA genes, restriction fragmentsfrom CA DNA are cloned into the expression vector pMT2 (Sambrook, etal., Molecular Cloning: A Laboratory Manual, Cold Spring HarborLaboratory Press pp 16.17-16.22 (1989)) and transfected into COS cellsgrown in DMEM supplemented with 10% FCS. Transfections are performedemploying calcium phosphate techniques (Sambrook, et al (1989) pp.16.32-16.40, supra) and cell lysates are prepared forty-eight hoursafter transfection from both transfected and untransfected COS cells.Lysates are subjected to analysis by immunoblotting using anti-peptideantibody.

[0391] In immunoblotting experiments, preparation of cell lysates andelectrophoresis are performed according to standard procedures. Proteinconcentration is determined using BioRad protein assay solutions. Aftersemi-dry electrophoretic transfer to nitrocellulose, the membranes areblocked in 500 mM NaCl, 20 mM Tris, pH 7.5, 0.05% Tween-20 (TTBS) with5% dry milk. After washing in TTBS and incubation with secondaryantibodies (Amersham), enhanced chemiluminescence (ECL) protocols(Amersham) are performed as described by the manufacturer to facilitatedetection.

Example 8 Generation of Antibodies Against Polypeptides

[0392] Polypeptides, unique to CA genes are synthesized or isolated frombacterial or other (e.g., yeast, baculovirus) expression systems andconjugated to rabbit serum albumin (RSA) with m-maleimido benzoic acidN-hydroxysuccinimide ester (MBS) (Pierce, Rockford, Ill.). Immunizationprotocols with these peptides are performed according to standardmethods. Initially, a pre-bleed of the rabbits is performed prior toimmunization. The first immunization includes Freund's complete adjuvantand 500 μg conjugated peptide or 100 μg purified peptide. All subsequentimmunizations, performed four weeks after the previous injection,include Freund's incomplete adjuvant with the same amount of protein.Bleeds are conducted seven to ten days after the immunizations.

[0393] For affinity purification of the antibodies, the corresponding CApolypeptide is conjugated to RSA with MBS, and coupled to CNBr-activatedSepharose (Pharmacia, Uppsala, Sweden). Antiserum is diluted 10-fold in10 mM Tris-HCl, pH 7.5, and incubated overnight with the affinitymatrix. After washing, bound antibodies are eluted from the resin with100 mM glycine, pH 2.5.

Example 9 Generation of Monoclonal Antibodies Against a CA Polypeptide

[0394] A non-denaturing adjuvant (Ribi, R730, Corixa, Hamilton Mont.) isrehydrated to 4 ml in phosphate buffered saline. 100 μl of thisrehydrated adjuvant is then diluted with 400 μl of Hank's Balanced SaltSolution and this is then gently mixed with the cell pellet used forimmunization. Approximately 500 μg conjugated peptide or 100 μg purifiedpeptide and Freund's complete are injected into Balb/c mice viafoot-pad, once a week. After 6 weeks of weekly injection, a drop ofblood is drawn from the tail of each immunized animal to test the titerof antibodies against CA polypeptides using FACS analysis. When thetiter reaches at least 1:2000, the mice are sacrificed in a CO₂ chamberfollowed by cervical dislocation. Lymph nodes are harvested forhybridoma preparation. Lymphocytes from mice with the highest titer arefused with the mouse myeloma line X63-Ag8.653 using 35% polyethyleneglycol 4000. On day 10 following the fusion, the hybridoma supernatantsare screened for the presence of CAP-specific monoclonal antibodies byfluorescence activated cell sorting (FACS). Conditioned medium from eachhybridoma is incubated for 30 minutes with a combined aliquot of PC3,Colo-205, LnCap, or Panc-1 cells. After incubation, the cell samples arewashed, resuspended in 0.1 ml diluent and incubated with 1 μg/ml of FITCconjugated F(ab′)2 fragment of goat anti-mouse IgG for 30 min at 4° C.The cells are washed, resuspended in 0.5 ml FACS diluent and analyzedusing a FACScan cell analyzer (Becton Dickinson; San Jose, Calif.).Hybridoma clones are selected for further expansion, cloning, andcharacterization based on their binding to the surface of one or more ofcell lines which express the CA polypeptide as assessed by FACS. Ahybridoma making a monoclonal antibody designated mAbCA which binds anantigen designated Ag-CA.x and an epitope on that antigen designatedAg-CA.x.1 is selected.

Example 10 ELISA Assay for Detecting CA Related Antigens

[0395] To test blood samples for antibodies that bind specifically torecombinantly produced CA antigens, the following procedure is employed.After a recombinant CA related protein is purified, the recombinantprotein is diluted in PBS to a concentration of 5 μg/ml (500 ng/100 μl).100 microliters of the diluted antigen solution is added to each well ofa 96-well Immulon 1 plate (Dynatech Laboratories, Chantilly, Va.), andthe plate is then incubated for 1 hour at room temperature, or overnightat 4° C., and washed 3 times with 0.05% Tween 20 in PBS. Blocking toreduce nonspecific binding of antibodies is accomplished by adding toeach well 200 μl of a 1% solution of bovine serum albumin in PBS/Tween20 and incubation for 1 hour. After aspiration of the blocking solution,100 μl of the primary antibody solution (anticoagulated whole blood,plasma, or serum), diluted in the range of {fraction (1/16)} to{fraction (1/2048)} in blocking solution, is added and incubated for 1hour at room temperature or overnight at 4° C. The wells are then washed3 times, and 100 μl of goat anti-human IgG antibody conjugated tohorseradish peroxidase (Organon Teknika, Durham, N.C.), diluted{fraction (1/500)} or {fraction (1/1000)} in PBS/Tween 20, 100 μl ofo-phenylenediamine dihydrochloride (OPD, Sigma) solution is added toeach well and incubated for 5-15 minutes. The OPD solution is preparedby dissolving a 5 mg OPD tablet in 50 ml 1% methanol in H₂O and adding50 μl 30% H₂O₂ immediately before use. The reaction is stopped by adding25 l of 4M H₂SO₄. Absorbances are read at 490 nm in a microplate reader(Bio-Rad).

Example 11 Identification and Characterization of CA Antigen on CancerCell Surface

[0396] A cell pellet of proximately 25 ul packed cell volume of a cancercell preparation is lysed by first diluting the cells to 0.5 ml in waterfollowed by freezing and thawing three times. The solution iscentrifuged at 14,000 rpm. The resulting pellet, containing the cellmembrane fragments, is resuspended in 50 μl of SDS sample buffer(Invitrogen, Carlsbad, Calif.). The sample is heated at 80° C. for 5minutes and then centrifuged for 2 minutes at 14,000 rpm to remove anyinsoluble materials.

[0397] The samples are analyzed by Western blot using a 4 to 20%polyacrylamide gradient gel in Tris-Glycine SDS (Invitrogen; CarlsbadCalif.) following the manufacturer's directions. Ten microliters ofmembrane sample are applied to one lane on the polyacrylamide gel. Aseparate 10 μL sample is reduced first by the addition of 2 μL ofdithiothreitol (100 mM) with heating at 80° C. for 2 minutes and thenloaded into another lane. Pre-stained molecular weight markers SeeBluePlus2 (Invitrogen; Carlsbad, Calif.) are used to assess molecular weighton the gel. The gel proteins are transferred to a nitrocellulosemembrane using a transfer buffer of 14.4 g/l glycine, 3 g/l of TrisBase, 10% methanol, and 0.05% SDS. The membranes are blocked, probedwith a CAP-specific monoclonal antibody (at a concentration of 0.5ug/ml), and developed using the Invitrogen WesternBreeze ChromogenicKit-AntiMouse according to the manufacturer's directions. In the reducedsample of the tumor cell membrane samples, a prominent band is observedmigrating at a molecular weight within about 10% of the predictedmolecular weight of the corresponding CA protein.

Example 12 Preparation of Vaccines

[0398] The present invention also relates to a method of stimulating animmune response against cells that express CA polypeptides in a patientusing CA polypeptides of the invention that act as an antigen producedby or associated with a malignant cell. This aspect of the inventionprovides a method of stimulating an immune response in a human againstcancer cells or cells that express CA polynucleotides and polypeptides.The method comprises the step of administering to a human an immunogenicamount of a polypeptide comprising: (a) the amino acid sequence of ahuma CA protein or (b) a mutein or variant of a polypeptide comprisingthe amino acid sequence of a human endogenous retrovirus CA protein.

Example 13 Generation of Transgenic Animals Expressing Polypeptides as aMeans for Testing Therapeutics

[0399] CA nucleic acids are used to generate genetically modifiednon-human animals, or site specific gene modifications thereof, in celllines, for the study of function or regulation of prostate tumor-relatedgenes, or to create animal models of diseases, including prostatecancer. The term “transgenic” is intended to encompass geneticallymodified animals having an exogenous CA gene(s) that is stablytransmitted in the host cells where the gene(s) may be altered insequence to produce a modified protein, or having an exogenous CA LTRpromoter operably linked to a reporter gene. Transgenic animals may bemade through a nucleic acid construct randomly integrated into thegenome. Vectors for stable integration include plasmids, retrovirusesand other animal viruses, YACs, and the like. Of interest are transgenicmammals, e.g. cows, pigs, goats, horses, etc., and particularly rodents,e.g. rats, mice, etc.

[0400] The modified cells or animals are useful in the study of CA genefunction and regulation. For example, a series of small deletions and/orsubstitutions may be made in the CA genes to determine the role ofdifferent genes in tumorigenesis. Specific constructs of interestinclude, but are not limited to, antisense constructs to block CA geneexpression, expression of dominant negative CA gene mutations, andover-expression of a CA gene. Expression of a CA gene or variantsthereof in cells or tissues where it is not normally expressed or atabnormal times of development is provided. In addition, by providingexpression of proteins derived from CA in cells in which it is otherwisenot normally produced, changes in cellular behavior can be induced.

[0401] DNA constructs for random integration need not include regions ofhomology to mediate recombination. Conveniently, markers for positiveand negative selection are included. For various techniques fortransfecting mammalian cells, see Keown et al., Methods in Enzymology185:527-537 (1990).

[0402] For embryonic stem (ES) cells, an ES cell line is employed, orembryonic cells are obtained freshly from a host, e.g. mouse, rat,guinea pig, etc. Such cells are grown on an appropriatefibroblast-feeder layer or grown in the presence of appropriate growthfactors, such as leukemia inhibiting factor (LIF). When ES cells aretransformed, they may be used to produce transgenic animals. Aftertransformation, the cells are plated onto a feeder layer in anappropriate medium. Cells containing the construct may be detected byemploying a selective medium. After sufficient time for colonies togrow, they are picked and analyzed for the occurrence of integration ofthe construct. Those colonies that are positive may then be used forembryo manipulation and blastocyst injection. Blastocysts are obtainedfrom 4 to 6 week old superovulated females. The ES cells aretrypsinized, and the modified cells are injected into the blastocoel ofthe blastocyst. After injection, the blastocysts are returned to eachuterine horn of pseudopregnant females. Females are then allowed to goto term and the resulting chimeric animals screened for cells bearingthe construct. By providing for a different phenotype of the blastocystand the ES cells, chimeric progeny can be readily detected.

[0403] The chimeric animals are screened for the presence of themodified gene and males and females having the modification are mated toproduce homozygous progeny. If the gene alterations cause lethality atsome point in development, tissues or organs are maintained asallogeneic or congenic grafts or transplants, or in in vitro culture.The transgenic animals may be any non-human mammal, such as laboratoryanimals, domestic animals, etc. The transgenic animals are used infunctional studies, drug screening, etc., e.g. to determine the effectof a candidate drug on prostate cancer, to test potential therapeuticsor treatment regimens, etc.

Example 14 Diagnostic Imaging Using CA Specific Antibodies

[0404] The present invention encompasses the use of antibodies to CApolypeptides to accurately stage cancer patients at initial presentationand for early detection of metastatic spread of cancer.Radioimmunoscintigraphy using monoclonal antibodies specific for CApolypeptides can provide an additional cancer-specific diagnostic test.The monoclonal antibodies of the instant invention are used forhistopathological diagnosis of carcinomas.

[0405] Subcutaneous human xenografts of cancer cells in nude mice isused to test whether a technetium-99m (^(99m)Tc)-labeled monoclonalantibody of the invention can successfully image the xenografted cancerby external gamma scintography as described for seminoma cells by Marks,et al., Brit. J. Urol. 75:225 (1995). Each monoclonal antibody specificfor a CA polypeptide is purified from ascitic fluid of BALB/c micebearing hybridoma tumors by affinity chromatography on proteinA-Sepharose. Purified antibodies, including control monoclonalantibodies such as an avidin-specific monoclonal antibody (Skea, et al.,J. Immunol. 151:3557 (1993)) are labeled with ^(99m)Tc followingreduction, using the methods of Mather, et al., J. Nucl. Med. 31:692(1990) and Zhang et al., Nucl. Med. Biol. 19:607 (1992). Nude micebearing human cancer cells are injected intraperitoneally with 200-500μCi of ^(99m)Tc-labeled antibody. Twenty-four hours after injection,images of the mice are obtained using a Siemens ZLC3700 gamma cameraequipped with a 6 mm pinhole collimator set approximately 8 cm from theanimal. To determine monoclonal antibody biodistribution followingimaging, the normal organs and tumors are removed, weighed, and theradioactivity of the tissues and a sample of the injectate are measured.Additionally, CA-specific antibodies conjugated to antitumor compoundsare used for cancer-specific chemotherapy.

Example 15 Immunohistochemical Methods

[0406] Frozen tissue samples from cancer patients are embedded in anoptimum cutting temperature (OCT) compound and quick-frozen inisopentane with dry ice. Cryosections are cut with a Leica 3050 CMmictrotome at thickness of 5 μm and thaw-mounted on vectabound-coatedslides. The sections are fixed with ethanol at −20° C. and allowed toair dry overnight at room temperature. The fixed sections are stored at−80° C. until use. For immunohistochemistry, the tissue sections areretrieved and first incubated in blocking buffer (PBS, 5% normal goatserum, 0.1% Tween 20) for 30 minutes at room temperature, and thenincubated with the CA protein-specific monoclonal antibody and controlmonoclonal antibodies diluted in blocking buffer (1 μg/ml) for 120minutes. The sections are then washed three times with the blockingbuffer. The bound monoclonal antibodies are detected with a goatanti-mouse IgG+IgM (H+L) F(ab′)²-peroxidase conjugates and theperoxidase substrate diaminobenzidine (1 mg/ml, Sigma Catalog No. D5637) in 0.1 M sodium acetate buffer pH 5.05 and 0.003% hydrogenperoxide (Sigma cat. No. H1009). The stained slides are counter-stainedwith hematoxylin and examined under Nikon microscope.

[0407] Monoclonal antibody against a CA protein (antigen) is used totest reactivity with various cell lines from different types of tissues.Cells from different established cell lines are removed from the growthsurface without using proteases, packed and embedded in OCT compound.The cells are frozen and sectioned, then stained using a standard IHCprotocol. The CellArray™ technology is described in WO 01/43869. Normaltissue (human) obtained by surgical resection are frozen and mounted.Cryosections are cut with a Leica 3050 CM mictrotome at thickness of 5μm and thaw-mounted on vectabound-coated slides. The sections are fixedwith ethanol at −20° C. and allowed to air dry overnight at roomtemperature. PolyMICA™ Detection kit is used to determine binding of aCA-specific monoclonal antibody to normal tissue. Primary monoclonalantibody is used at a final concentration of 1 μg/ml.

[0408] All publications and patent applications cited in thisspecification are herein incorporated by reference as if each individualpublication or patent application were specifically and individuallyindicated to be incorporated by reference.

[0409] Although the foregoing invention has been described in somedetail by way of illustration and example for purposes of clarity ofunderstanding, it will be readily apparent to those of ordinary skill inthe art in light of the teachings of this invention that certain changesand modifications may be made thereto without departing from the spiritor scope of the appended claims.

What is claimed is:
 1. An isolated nucleic acid comprising at least 10contiguous nucleotides of a sequence selected from the group consistingof the human polynucleotide mRNA sequences of SEQ ID NOS: 5, 11, 17, 23,29 and 32 shown in Tables 1-6, or its complement.
 2. A host cellcomprising a recombinant nucleic acid of claim
 1. 3. An expressionvector comprising the isolated nucleic acid according to claim
 1. 4. Ahost cell comprising the expression vector of claim
 3. 5. Thepolynucleotide according to claim 1, wherein said polynucleotide, or itscomplement or a fragment thereof, further comprises a detectable label.6. The polynucleotide according to claim 1, wherein said polynucleotide,or its complement or a fragment thereof, is attached to a solid support.7. The polynucleotide according to claim 1, wherein said polynucleotide,or its complement or a fragment thereof, is prepared at least in part bychemical synthesis.
 8. The polynucleotide according to claim 1, whereinsaid polynucleotide, or its complement or a fragment thereof, is anantisense fragment.
 9. The polynucleotide according to claim 1, whereinsaid polynucleotide, or its complement or a fragment thereof, is singlestranded.
 10. The polynucleotide according to claim 1, wherein saidpolynucleotide, or its complement or a fragment thereof, is doublestranded.
 11. The polynucleotide according to claim 1, comprising atleast 15 contiguous nucleotides.
 12. The polynucleotide according toclaim 1, comprising at least 20 contiguous nucleotides.
 13. A microarrayfor detecting a cancer associated (CA) nucleic acid comprising: at leastone probe comprising at least 10 contiguous nucleotides of a sequenceselected from the group consisting of the human polynucleotide sequencesof SEQ ID NOS: 5, 11, 17, 23, 29 and 32 shown in Tables 1-6, or itscomplement.
 14. The microarray according to claim 13, comprising atleast 15 contiguous nucleotides.
 15. The microarray according to claim13, comprising at least 20 contiguous nucleotides.
 16. An isolatedpolypeptide, encoded within an open reading frame of a CA sequenceselected from the group consisting of the human genomic polynucleotidesequences of SEQ ID NOS: 4, 10, 16, 22, 28 and 31 shown in Tables 1-6,or its complement.
 17. The polypeptide of claim 16, wherein saidpolypeptide comprises the amino acid sequence encoded by a humanpolynucleotide selected from the group consisting of SEQ ID NOS: 5, 11,17, 23, 29 and 32 shown in Tables 1-6.
 18. The polypeptide of claim 16,wherein said polypeptide comprises the amino acid sequence encoded by ahuman coding sequence selected from the group consisting of, SEQ ID NOS:6, 12, 18, 24, 30 and 33 shown in Tables 1-6.
 19. The polypeptide ofclaim 16, wherein said polypeptide comprises the amino acid sequence ofan epitope of the amino acid sequence of a CA polypeptide selected fromthe group consisting of SEQ ID NOS: 6, 12, 18, 24, 30 and 33 shown inTables 1-6.
 20. The polypeptide of claim 16, wherein said polypeptide orfragment thereof is attached to a solid support.
 21. An isolatedantibody or antigen binding fragment thereof, that binds to apolypeptide according to anyone of claims 16-20.
 22. The isolatedantibody or antigen binding fragment thereof according the claim 21,wherein said antibody or fragment thereof is attached to a solidsupport.
 23. The isolated antibody or antigen binding fragment thereofaccording the claim 21, wherein said antibody is a monoclonal antibody.24. The isolated antibody or antigen binding fragment thereof accordingthe claim 21, wherein said antibody is a polyclonal antibody.
 25. Theisolated antibody or antigen binding fragment thereof according theclaim 21, wherein said antibody or fragment thereof further comprises adetectable label.
 26. An isolated antibody that binds to a polypeptide,or antigen binding fragment thereof, according to any of claims 16-20,prepared by a method comprising the following steps of: (i) immunizing ahost animal with a composition comprising said polypeptide, or antigenbinding fragment thereof, and ii) collecting cells from said hostexpressing antibodies against the antigen or antigen binding fragmentthereof.
 27. A kit for diagnosing the presence of cancer in a testsample, said kit comprising at least one polynucleotide that selectivelyhybridizes to a CA polynucleotide sequence selected from the groupconsisting of the polynucleotide sequences of SEQ ID NOS: 4, 10, 16, 22,28 and 31 shown in Tables 1-6, a fragment thereof, or their complement.28. A kit for diagnosing the presence of cancer in a test sample, saidkit comprising at least one polynucleotide that selectively hybridizesto the sequence of a polynucleotide sequence selected from the groupconsisting of the polynucleotide sequences of SEQ ID NOS: 5, 11, 17, 23,29 and 32 shown in Tables 1-6, a fragment thereof, or their complement.29. An electronic library comprising a polynucleotide, or fragmentthereof, comprising a CA polynucleotide sequence selected from the groupconsisting of the polynucleotide sequences of SEQ ID NOS: 4, 10, 16, 22,28 and 31 shown in Tables 1-6.
 30. An electronic library comprising apolynucleotide, or fragment thereof, comprising a CA polynucleotidesequence selected from the group consisting of the polynucleotidesequences of SEQ ID NOS: 5, 11, 17, 23, 29 and 32 shown in Tables 1-6.31. An electronic library comprising a polypeptide, or fragment thereof,comprising a CA polypeptide encoded by a polynucleotide of a sequenceselected from the group consisting of the polynucleotide sequences ofSEQ ID NOS: 6, 12, 18, 24, 30 and 33 shown in Tables 1-6.
 32. A methodfor screening for anticancer activity in a potential drug, the methodcomprising: (a) providing a cell that expresses a cancer associated (CA)gene encoded by a nucleic acid sequence selected from the groupconsisting of the sequences of SEQ ID NOS: 4, 10, 16, 22, 28 and 31shown in Tables 1-6 or fragment thereof; (b) contacting a tissue samplederived from a cancer cell with an anticancer drug candidate; and (c)monitoring an effect of the anticancer drug candidate on an expressionof the CA gene in the tissue sample.
 33. The method of screening foranticancer activity according to claim 32, wherein the CA gene comprisesat least one nucleic acid sequence selected from the group consisting ofthe sequences of SEQ ID NOS: 5, 11, 17, 23, 29 and 32 shown in Tables1-6.
 34. The method of screening for anticancer activity according toclaim 32, further comprising: (d) comparing the level of expression ofthe in the absence of said drug candidate to the level of expression inthe presence of the drug candidate.
 35. The method of screening foranticancer activity according to claim 33, wherein the drug candidatemodulates the activity of a CAP sequence selected from the groupconsisting of SNL, FOSB, CCND1, MYC, NFKB1, and PVT1.
 36. A method fordetecting cancer associated with expression of a polypeptide in a testcell sample, comprising the steps of: (i) detecting a level ofexpression of at least one polypeptide having an amino acid sequenceencoded by a human coding sequence selected from the group consisting ofof SEQ ID NOS: 6, 12, 18, 24, 30 and 33 shown in Tables 1-6, or afragment thereof; and (ii) comparing the level of expression of thepolypeptide in the test sample with a level of expression of polypeptidein a normal cell sample, wherein an altered level of expression of thepolypeptide in the test cell sample relative to the level of polypeptideexpression in the normal cell sample is indicative of the presence ofcancer in the test cell sample.
 37. A method for detecting cancerassociated with expression of a polypeptide in a test cell sample,comprising the steps of: (i) detecting a level of activity of at leastone polypeptide having an amino acid sequence encoded by a human codingsequence selected from the group consisting of of SEQ ID NOS: 6, 12, 18,24, 30 and 33 shown in Tables 1-6, or a fragment thereof, wherein saidactivity corresponds to at least one activity for the polypeptide listedin Table 130; and (ii) comparing the level of activity of thepolypeptide in the test sample with a level of activity of polypeptidein a normal cell sample, wherein an altered level of activity of thepolypeptide in the test cell sample relative to the level of polypeptideactivity in the normal cell sample is indicative of the presence ofcancer in the test cell sample.
 38. A method for detecting cancerassociated with the presence of an antibody in a test serum sample,comprising the steps of: (i) detecting a level of an antibody against anantigenic polypeptide having an amino acid sequence encoded by a humancoding sequence selected from the group consisting of of SEQ ID NOS: 6,12, 18, 24, 30 and 33 shown in Tables 1-6, or antigenic fragmentthereof; and (ii) comparing said level of said antibody in the testsample with a level of said antibody in the control sample, wherein analtered level of antibody in said test sample relative to the level ofantibody in the control sample is indicative of the presence of cancerin the test serum sample.
 39. A method for screening for a bioactiveagent capable of modulating the activity of a CA protein (CAP), whereinsaid CAP is encoded by a nucleic acid comprising a nucleic acid sequenceselected from the group consisting of the polynucleotide sequences ofSEQ ID NOS: 5, 11, 17, 23, 29 and 32 shown in Tables 1-6, said methodcomprising: a) combining said CAP and a candidate bioactive agent; andb) determining the effect of the candidate agent on the bioactivity ofsaid CAP.
 40. The method of screening for the bioactive agent accordingto claim 39, wherein the bioactive agent affects the expression of theCA protein (CAP).
 41. The method of screening for the bioactive agentaccording to claim 39, wherein the bioactive agent affects the activityof the CA protein (CAP), wherein the CAP is selected from the groupconsisting of SNL, FOSB, CCND1, MYC, NFKB1, and PVT1.
 42. A method fordiagnosing cancer comprising: a) determining the expression of one ormore genes comprising a nucleic acid sequence selected from the groupconsisting of the human sequences outlined in Tables 1-6, in a firsttissue type of a first individual; and b) comparing said expression ofsaid gene(s) from a second normal tissue type from said first individualor a second unaffected individual; wherein a difference in saidexpression indicates that the first individual has cancer.
 43. Themethod for diagnosing cancers according to claim 42, wherein thedifference in said expression indicates that the first individual has apropensity towards cancer.
 44. The method for diagnosing cancersaccording to claim 42, wherein the gene comprises SNL1 sequencescorresponding to SEQ ID NOS: 4, 5 and 6 and the tissue is breast cancertissue.
 45. The method for diagnosing cancers according to claim 42,wherein the gene comprises FOSB sequences corresponding to SEQ ID NOS:10-12 and the tissue is selected from the group consisting of coloncancer, lung cancer, pancreatic cancer, ovarian cancer, stomach cancer,breast cancer and prostate cancer tissue.
 46. The method for diagnosingcancers according to claim 42, wherein the gene comprises MYC sequencescorresponding to SEQ ID NOS: 22-24 and the tissue is breast cancertissue.
 47. The method for diagnosing cancers according to claim 42,wherein the gene comprises an CCND1 sequences corresponding to SEQ IDNOS: 16-18 and the tissue is selected from the group consisting of coloncancer (sigmoid), colon cancer (transverse), lung cancer, ovariancancer, and breast cancer tissue.
 48. The method for diagnosing cancersaccording to claim 42, wherein the gene comprises an NFKB1 sequencescorresponding to SEQ ID NOS: 28-30 and the tissue is selected from thegroup consisting of lung cancer, skin cancer, and breast cancer tissue.49. The method for diagnosing cancers according to claim 42, wherein thegene comprises PVT1 sequences corresponding to SEQ ID NOS: 31-33 and thetissue is breast cancer tissue.
 50. The method for diagnosing cancersaccording to claim 42, wherein the gene expression in the cancer tissueis up-regulated relative to the gene expression in the normal tissue.51. The method for diagnosing cancers according to claim 50, wherein thedifference in said expression indicates that the first individual has apropensity towards cancer.
 52. A method for diagnosing cancer or apropensity towards cancer comprising determining the amplification ofone or more genes comprising a DNA sequence selected from the groupconsisting of the human sequences outlined in Tables 1-6, in a firsttissue type of a first individual relative to a second normal tissuetype from said first individual or a second unaffected individual,wherein an amplification of the DNA indicates that the first individualhas cancer or a propensity towards cancer.
 53. The method for diagnosingcancer or a propensity towards cancer according to claim 52, wherein thegene comprises MYC and the DNA sequence is SEQ ID NO: 22, or a fragmentthereof.
 54. The method for diagnosing cancer or a propensity towardscancer according to claim 52, wherein the gene comprises PVT1 and theDNA sequence is SEQ ID NO: 31, or a fragment thereof.
 55. A method fortreating cancers comprising administering to a patient an inhibitor of aCA protein (CAP), wherein said CAP is encoded by a nucleic acidcomprising a human nucleic acid sequence selected from the groupconsisting of the sequences outlined in Tables 1-6.
 56. The method fortreating cancers according to claim 55, wherein the inhibitor of a CAprotein (CAP) binds to the CA protein.
 57. The method for treatingcancers according to claim 55, wherein the inhibitor of a CA protein(CAP) modulates the activity of a CAP sequence selected from the groupconsisting of SNL, FOSB, CCND1, MYC, NFKB1, and PVT1.